MEDICATION GUIDE. PROCRIT (PRO KRIT) (epoetin alfa)
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1 MEDICATION GUIDE PROCRIT (PROKRIT) (epoetin alfa) Read this Medication Guide: before you start PROCRIT. if you are told by your healthcare provider that there is new information about PROCRIT. if you are told by your healthcare provider that you may inject PROCRIT at home, read this Medication Guide each time you receive a new supply of medicine. This Medication Guide does not take the place of talking to your healthcare provider about your medical condition or your treatment. Talk with your healthcare provider regularly about the use of PROCRIT and ask if there is new information about PROCRIT. What is the most important information I should know about PROCRIT? PROCRIT may cause serious side effects that can lead to death, including: For people with cancer: Your tumor may grow faster and you may die sooner if you choose to take PROCRIT. Your healthcare provider has received special training in order to prescribe PROCRIT and will talk with you in detail about these risks. For all people who take PROCRIT, including people with cancer or chronic kidney disease: Serious heart problems, such as heart attack or heart failure, and stroke. You may die sooner if you are treated with PROCRIT to increase red blood cells (RBCs) to near the same level found in healthy people. Blood clots. Blood clots may happen at any time while taking PROCRIT. If you are receiving PROCRIT for any reason and you are going to have surgery, talk to your healthcare provider about whether or not you need to take a blood thinner to lessen the chance of blood clots during or following surgery. Clots can form in blood vessels (veins), especially in your leg (deep venous thrombosis or DVT). Pieces of a blood clot may travel to the lungs and block the blood circulation in the lungs (pulmonary embolus). Call your healthcare provider or get medical help right away if you have any of these symptoms: Chest pain Trouble breathing or shortness of breath Pain in your legs, with or without swelling A cool or pale arm or leg Sudden confusion, trouble speaking, or trouble understanding others speech Sudden numbness or weakness in your face, arm, or leg, especially on one side of your body Sudden trouble seeing Sudden trouble walking, dizziness, loss of balance or coordination Loss of consciousness (fainting) Hemodialysis vascular access stops working See What are the possible side effects of PROCRIT? below for more information. If you decide to take PROCRIT, your healthcare provider should prescribe the smallest dose of PROCRIT that is necessary to reduce your chance of needing RBC transfusions.
2 What is PROCRIT? PROCRIT is a prescription medicine used to treat anemia. People with anemia have a lower-than-normal number of RBCs. PROCRIT works like the human protein called erythropoietin to help your body make more RBCs. PROCRIT is used to reduce or avoid the need for RBC transfusions. PROCRIT may be used to treat anemia if it is caused by: Chronic kidney disease (you may or may not be on dialysis). Chemotherapy that will be used for at least two months after starting PROCRIT. A medicine called zidovudine (AZT) used to treat HIV infection. PROCRIT may also be used to reduce the chance you will need RBC transfusions if you are scheduled for certain surgeries where a lot of blood loss is expected. If your hemoglobin level stays too high or if your hemoglobin goes up too quickly, this may lead to serious health problems which may result in death. These serious health problems may happen if you take PROCRIT, even if you do not have an increase in your hemoglobin level. PROCRIT should not be used for treatment of anemia: If you have cancer and you will not be receiving chemotherapy that may cause anemia. If you have a cancer that has a high chance of being cured. Talk with your healthcare provider about the kind of cancer you have. In place of emergency treatment for anemia (RBC transfusions). PROCRIT has not been proven to improve quality of life, fatigue, or well-being. PROCRIT should not be used to reduce the chance of RBC transfusions if: You are scheduled for surgery on your heart or blood vessels. You are able and willing to donate blood prior to surgery. Who should not take PROCRIT? Do not take PROCRIT if you: Have cancer and have not been counseled by your healthcare provider about treatment with PROCRIT. Have high blood pressure that is not controlled (uncontrolled hypertension). Have been told by your healthcare provider that you have or have ever had a type of anemia called Pure Red Cell Aplasia (PRCA) that starts after treatment with PROCRIT or other erythropoietin protein medicines. Have had a serious allergic reaction to PROCRIT. Do not give PROCRIT from multidose vials to: Pregnant or breastfeeding women Babies What should I tell my healthcare provider before taking PROCRIT? PROCRIT may not be right for you. Tell your healthcare provider about all your health conditions, including if you: Have heart disease. Have high blood pressure. Have had a seizure (convulsion) or stroke. Have any other medical conditions. 2
3 Are pregnant or planning to become pregnant. It is not known if PROCRIT may harm your unborn baby. Talk to your healthcare provider about possible pregnancy and birth control choices that are right for you. Are breastfeeding or planning to breastfeed. It is not known if PROCRIT passes into breast milk. Tell your healthcare provider about all the medicines you take, including prescription and nonprescription medicines, vitamins, and herbal supplements. Know the medicines you take. Keep a list of your medicines with you and show it to your healthcare provider when you get a new medicine. How should I take PROCRIT? If you or your caregiver has been trained to give PROCRIT shots (injections) at home: o Be sure that you read, understand, and follow the Instructions for Use that come with PROCRIT. o Take PROCRIT exactly as your healthcare provider tells you to. Do not change the dose of PROCRIT unless told to do so by your healthcare provider. o Your healthcare provider will show you how much PROCRIT to use, how to inject it, how often it should be injected, and how to safely throw away the used vials, syringes, and needles. o If you miss a dose of PROCRIT, call your healthcare provider right away and ask what to do. o If you take more than the prescribed amount of PROCRIT, call your healthcare provider right away. During treatment with PROCRIT, continue to follow your healthcare provider s instructions for diet and medicines. Have your blood pressure checked as instructed by your healthcare provider. What are the possible side effects of PROCRIT? PROCRIT may cause serious side effects. See What is the most important information I should know about PROCRIT? High blood pressure. High blood pressure is a common side effect of PROCRIT in patients with chronic kidney disease. Your blood pressure may go up or be difficult to control with blood pressure medicine while taking PROCRIT. This can happen even if you have never had high blood pressure before. Your healthcare provider should check your blood pressure often. If your blood pressure does go up, your healthcare provider may prescribe new or more blood pressure medicine. Seizures. If you have any seizures while taking PROCRIT, get medical help right away and tell your healthcare provider. Antibodies to PROCRIT. Your body may make antibodies to PROCRIT. These antibodies can block or lessen your body s ability to make RBCs and cause you to have severe anemia. Call your healthcare provider if you have unusual tiredness, lack of energy, dizziness, or fainting. You may need to stop taking PROCRIT. Serious allergic reactions. Serious allergic reactions can cause a rash over your whole body, shortness of breath, wheezing, dizziness and fainting because of a drop in blood pressure, swelling around your mouth or eyes, fast pulse, or sweating. If you have a serious allergic reaction, stop using PROCRIT and call your healthcare provider or get medical help right away. Dangers of using PROCRIT from multi-dose vials in newborns, infants, and pregnant or breastfeeding women. Do not use PROCRIT from multi-dose vials in newborns, infants, pregnant or breastfeeding women because the PROCRIT in these vials contains benzyl alcohol. Benzyl alcohol has been shown to cause brain damage, other serious side effects, and death in newborn and premature babies. PROCRIT that comes in single-dose vials does not contain benzyl alcohol. See Who should not take PROCRIT? Common side effects of PROCRIT include: joint, muscle, or bone pain fever 3
4 cough rash nausea vomiting soreness of mouth itching headache redness and pain in the skin where PROCRIT shots were given These are not all of the possible side effects of PROCRIT. Your healthcare provider can give you a more complete list. Tell your healthcare provider about any side effects that bother you or that do not go away. Call your doctor for medical advice about side effects. You may report side effects to FDA at FDA How should I store PROCRIT? Do not shake PROCRIT. Protect PROCRIT from light. Store PROCRIT in the refrigerator between 36 F to 46 F (2 C to 8 C). Do not freeze PROCRIT. Do not use PROCRIT that has been frozen. Throw away multidose vials of PROCRIT no later than 21 days from the first day that you put a needle into the vial. Single-dose vials of PROCRIT should be used only one time. Throw the vial away after use even if there is medicine left in the vial. Keep PROCRIT and all medicines out of the reach of children. General information about PROCRIT Medicines are sometimes prescribed for purposes other than those listed in a Medication Guide. Use PROCRIT only for the condition for which it has been prescribed. Do not give PROCRIT to other patients even if they have the same symptoms that you have. It may harm them. This Medication Guide summarizes the most important information about PROCRIT. If you would like more information about PROCRIT, talk to your healthcare provider. You can ask your healthcare provider or pharmacist for information about PROCRIT that is written for healthcare professionals. For more information, go to the following website: or call JANSSEN ( ). What are the ingredients in PROCRIT? Active Ingredient: epoetin alfa Inactive Ingredients: Multidose vials contain benzyl alcohol. All vials contain albumin (human), sodium citrate, sodium chloride, and citric acid. Single-dose vials containing 40,000 Units of PROCRIT also contain sodium phosphate monobasic monohydrate and sodium phosphate dibasic anhydrate. This Medication Guide has been approved by the U.S. Food and Drug Administration. Manufactured by: Amgen Inc. One Amgen Center Drive 4
5 Thousand Oaks, CA U.S.A. Manufactured for: Janssen Products, LP Horsham, Pennsylvania Janssen Products, LP 2000 Printed in U. S. A. Revised: 12/2013 5
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