VOLUFORM TM. Volufirming. echnology. face. and. Bust. 3 SEPPIC patents. 3 in vivo

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Andra Booth
7 years ago
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1 TM O O Volufirming echnology T face senior anti-ageing and Bust 3 SEPPIC patents seductive form 3 in vivo tests

2 Volufirming technology Acts on all the layers of the skin where it is needed most VOLUME effect on healthy adipocytes both young and old! Stimulates functionality of the adipocytes and prevents them ageing into MAD cells Pre-adipocytes aged skin young skin deteriorated differentiation + + normal differentiation restored differentiation = + 30%** MAD cells Non-functional adipocytes = Loss of skin volume Functional adipocytes = Increased skin volume FIRMING effect of the fibroblasts for a reinforced meshing Keep fitness for fibroblasts Optimization of the contractile forces of the fibroblasts (+ 94%** after 48h) for better collagen organization Increase in the dynamic interactions between the fibroblasts and the Dermal Matrix More focal adhesion complexes for better anchoring Dermis treated with Optimized dynamic contractile force + focal adhesion complexes Balance of the Extracellular Matrix Voluform gives skin back its fundamental substance Restoration of the gene expression of collagen ( -1 collagen-1: + 8%**) and of its chaperone protein (serpin-1h: +26%**) and protects the Extracellular Matrix (- 77%***MMP-2, + 55%** TIMP-2) DETOX effect Stimulation of the proteasome, a powerful cellular detoxifier Enzymatic system turned sluggish by stress or ageing is reactivated to remove damaged proteins (stimulation of catalytic activities: chymotrypsin-like, trypsin-like, caspase-like) Anti-oxidant action 48% inhibition of the OH- hydroxyl radical, a very reactive participant in the radical cascade *: p< 0,05 **: p< 0,01 ***: p< 0,001 (I) Metalloprotéinase-2 (II) Tissue Inhibitors of Metalloproteinase-2

3 face A global response to ageing in mature skin VOLUME and ELASTICITY effect A face redesigned, a younger look! Placebo 1% D56 D56 +0,784 ml/do 1% (formula EU07092) versus placebo - 56 days of treatment - 12 women (cheek) - Fringe projection and ballistometry before () and after (D56) treatment D56 Superposition of red and blue lines: no effect after treatment Cheeks re-plumped for 83% of the volunteers Newly supple skin + 10%* elasticity versus placebo More elasticity for 83% of the volunteers Wrinkle CORRECTOR A face sculpted from the inside out Level 0 = market reference (3% anti-ageing lipopeptide) 0 Number of deep wrinkles - 39%* Number of medium wrinkles - 36%* Total wrinkled surface - 24% 1% *p<0,05 p<0,1 1% (formula EU07092) versus market reference (3% anti-ageing lipopeptide) - 42 days of treatment Siflo replica of crow s feet - Quantirides software YOUTHFULNESS effect A renewed epidermis, a skin radiant with beauty 700% 697%* 600% 500% 400% 300% 200% 100% 0% 436%* 0,0001% (in vitro) versus CaCl2 Immunolabelling against filaggrin, (marker for keratinocyte differentiation) 0,02% ma CaCI2 0,0001% Voluform % Stimulation of keratinocyte differentiation/control

4 Bust A re-plumping and restructuring effect on the breasts VOLUME Effect A bust that s in top form! Placebo no change in volume after treatment 1% (formula EU07092) versus placebo - 28 days of treatment - Fringe projection and centimeter measurements on and D28 1% increased volume after one month of treatment Gain a cup size: Up to 2 cm increase in bust circumference (0.6 cm on average) More volume for 83% of the volunteers Centimeter increase for 60% of the volunteers PUSH UP effect: Throw away your push-up bras! + 5%* increase in thickness of the hypodermis versus placebo on the upper anterior surface Protocol : 1% (formula EU07092) versus placebo - 28 days of treatment - Low-frequency echography Push-up effect for 79% of the volunteers No change on the other surfaces FIRMING effect For added beauty! Placebo: no significant change D28 1% (formule EU07092) versus placebo - 28 days of treatment - High-frequency echography (1%): + 6%* %* of dermal + epidermal thickness/ Dermis Epidermis D28 Thicker skin for 61% of the volunteers

5 INCI name: Palmitoyl Isoleucine Preservative free Ecocert certified Volufirming face (EU07092) - ph = 6 Proven effect in vivo A LANOL P MONTANOV 202 MONTANOV 82 Squalane Polyisobutene B Aqua/Water Chlorphenesin Triethanolamine Glycerin C Xanthan Gum D SEPIPLUS 400 E SEPICIDE LD Parfum/Fragrance 1.50% 2.00% 7.00% 13.00% Qsp 100% 0.30% Qs 5.00% 0.15% 0.80% 0.70% 0.10% Voluform natural alternative to lipofilling Push-up potion (EU07093) - ph = 5 Proven effect in vivo A Aqua/Water Glycerin B Mineral Oil Butyrospermum Parkii (Shea Butter) Neopentyl Glycol Diethylhexanoate MONTANOV 202 C SIMULGEL INS 100 D Phenoxyethanol and Methylparaben and Propylparaben and Methylisothiazolinone E Parfum/Fragrance Qsp 100% 3.00% 8.00% 1.50% 5.00% 2.00% 0.50% 0.50% Volume and firmness for the face and Bust Use level: 1%

6 from 60 years Plumping & "Calcium like" from 50 years Voluform Givobio GCa Sepitonic M4 "Hormone like" & Wrinkles corrector & Cell longevity a solution for every age from 40 years PhytoAge Survicode Wrinkles corrector & Tightener & Lightener from 30 years Anti-ageing & Energizer Sesaflash Sepiwhite MSH Timecode Sepicalm VG from 20 years Voluform an active ingredient for each generation Hydration Sepilift DPHP Sepitonic M3 for all ages Aquaxyl Radical Protection & Photoprotection from an early age for a bust that s in top form from 60, for a younger look Survicode Sepilift DPHP PhytoAge Extramel C Manoliva Sepitonic M3 Givobio GMn Sepivital Sepivinol Nota The analytical specifications warranted are only those mentioned on the certificate of analysis supplied with each delivery of the product. Except as set forth above, SEPPIC* makes no warranties, whether express, implied or statutory, as to the product which is the subject of this document. Without limiting the generality of the foregoing, SEPPIC* makes no warranty of merchantability of the product or of the fitness of the product for any particular purpose. Buyer assumes all risk and liability resulting from the use or sale of the product, whether singly or in combination with other goods. The information set forth herein is furnished free of charge and is based on technical data that SEPPIC* believes to be reliable. It is intended for use by persons having technical skill and at their own discretion and risk. Since conditions of use are outside SEPPIC*'s control, SEPPIC* makes no warranties, express or implied, and assumes no liability in connection with any use of this information. Nothing herein is to be taken as a license to operate under or a recommendation to infringe any patents SEPPIC - TM is registered as Trade Mark of SEPPIC - SEPPIC* a subsidiary of the AIR LIQUIDE group. *SEPPIC being: SEPPIC S.A. FRANCE Tel.: + 33(0) Head Office 75, quai d Orsay Paris FRANCE SEPPIC Brasil BRAZIL Tel.: SEPPIC UK Ltd ENGLAND Tel.: SEPPIC Inc. USA Tel.: SEPPIC GmbH GERMANY Tel.: + 49 (0) SEPPIC ITALIA Srl ITALY Tel.: SEPPIC China CHINA Tel.: + 86(21) SEPPIC Asia Singapore SINGAPORE Tel.: C/4376/Fr/01/C/4399e/GB/02/March Design: Gris Souris - Photos: Fotolia - Seppic - PhotoAlto

AQUAXYL. Hydra. concept. An innovative moisturizing. and. restructuring. technology. www.seppic.com

AQUAXYL. Hydra. concept. An innovative moisturizing. and. restructuring. technology. www.seppic.com AQUAXYL Hydra concept An innovative moisturizing and restructuring technology www.seppic.com HYDRACNCEPT A "Moisturizing and Restructuring" efficacy achieved by the harmonization of sin s hydrous flow.