SCIENTIFIC CURRICULUM October 2013

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1 SCIENTIFIC CURRICULUM October 2013 Research Areas Research Coordinators: Dr. Eng. Laurent Aubouy: Meritxell De la Varga: YOUR TECHNOLOGICAL PARTNER LEITAT Technological Center Phone Fax

2 LEITAT Technological Center VOCATION We offer high added value solutions to technological challenges required by companies, with a clear guidance and vocational adaptation to the constant market changes. FUTURE VISION We support sustainable growth through the promotion of R+D+I and technology transfer, in the context of creating lasting value for companies, satisfying the changing demands of global market. RESEARCH UNITS From a traditional structure to a flexible and dynamic organization, LEITAT seeks to ensure a rapid and effective response by reducing levels of decision-making and bureaucracy. Prioritizing teams work and projects with a horizontal communication and a definition of responsibilities in order to achieve meet the expectations of the client and society. 2

3 INDEX Page INDUSTRIAL BIOTECHNOLOGY 4 BIOINVITRO 7 BIOMED 10 NANOHEALTH & SAFETY 13 ANALYTICAL CHEMISTRY 16 FAST MOVING CONSUMER GOODS 19 NANOMATERIALS 22 ADVANCED POLYMERS 25 SURFACE TREATMENTS 28 TEXTILE TECHNOLOGIES 31 SMART SYSTEMS 34 NEW PRODUCTION PROCESSES 37 ENVIRONMENT 40 RENEWABLE ENERGIES 43 LEITAT TECHNOLOGICAL CENTER IS MEMBER OF 46 EUROPEAN TECHNOLOGY PLATFORMS 46 SPANISH TECHNOLOGY PLATFORMS 47 3

4 INDUSTRIAL BIOTECHNOLOGY Competency Compendium Dr. Anna SURRIBAS Coordinator of Industrial Biotechnology Division Equipments: Bioreactors Incubators Equipment for protein/enzyme activity characterization (SDS-PAGE) Microbiology laboratory Microscopy facilities Dispermat CV3 Spray drier Rulla Quirsec Pilot scale fat crystallizer Pilot scale homogenizer SPECIFIC RESEARCH INTERESTS Bioprocess development: - Design and application of bioprocesses in industrial environment: use of enzymes and microorganisms: Several activities can be addressed from biocatalyst screening, modification and bioprocess development. Several analytical technologies can be set up for process monitoring. - Enzyme immobilization, recuperation and reutilization. Kinetic studies: Immobilization systems can be selected from commercial sources or specially designed and synthesized for custom needs by micro and nanotechnologies. Enzyme activity protocols can be set up to follow enzyme activity during immobilization. Several separation technologies can be studied ranging from filtration, magnetic separation, centrifugation - Substitution of organic conventional reactions by biocatalytic reactions: Given a chemical process, several alternatives can be designed in order to include biotechnological routes for the synthesis of certain intermediates or products. Activities can include the process strategy, biocatalyst selection and process development. Product analysis and separation can be also addressed. - Isolation, selection and characterization of microorganisms for different applications and functionalities: Novel microorganism can be isolated by strategic sampling according to the desired applications, for example contaminated soils for contaminant-degrading microorganisms. Screening methods can be designed to select the best strains. Environmental Biotechnology. - Biotechnological wastewater treatment: Both enzymatic and microbial processes for the environmental sector can be developed. Activities include the development of enzymatic processes for wastewater treatment, isolation of new microbial consortia, anaerobic digestionetc.. 4

5 - By-product/waste valorisation: Biotechnological processes can be designed for the valorisation of certain by products. Activities have been addressed for the recovery of by product fibres, protein hydrolysates, feed, biopolymers. - Microbial/Enzymatic fuel cells technology: MFC can be designed with preferred microorganisms or novel electrode materials for electricity recovery. Applied microbiology: - Application of antimicrobial/antimite ingredients and validation of their activity: Antimicrobial products can be applied on different substrates (textiles, polymeric materials, membranes) and surfaces and their antimicrobial behaviour can be assessed through international standards. - Tailor made microbiological research: Tailor made microbiological research activities can be designed to fulfil customer needs: study of biofilm formation, validation of higienization technologies, evaluation of antimicrobial compounds and antimicrobial behaviour of products (detergents, cosmetics, food conservants ) Microencapsulation for several industrial sectors: textiles, food, cosmetics, etc. Development of tailor-made microcapsules for applications in several industrial sectors. Activities include: microcapsules development (using chemical technologies: Coacervation, gelation, interfacial polymerization, sol-gel; spray-drying;); microcapsule characterization and release and stability studies. Identification of valuable compounds from natural origin Screening methodologies for identifying novel added-value compounds from natural resources into biologically valuable compounds. Development of improved fat based products Downstream processing. Several technologies and processes can be developed and applied for downstream applications: membrane and tubular filtration, filter press, centrifugation Filtration technologies are available at a pilot scale. Purification methodologies can be developed according to custom needs. Equipment for protein purification by FPLC is available. MOST RELEVANT PROJECTS 1. ITACA: Research on Technologies of treatment, reuse and monitoring for future sustainability of water treatment. INNPRONTA 2011, IPT BioConSepT: Integration of Bio-Conversion and Separation Technology for the production and application of platform chemicals from 2nd generation biomass. FP7-KBBE BioXplore: Novel methodology for the identification of valuable natural products derived from Mediterranean Flora. ENPI 4. MICROSEGA: Biopolymeric microcapsules for food safety applications. VALOR LIQUION: Research on ionic liquid technologies for industrial applications. Co-financed by CDTI. CEN PHILYRA: Microbiological characterization on textiles. Henkel KGaA Research in Healthy Foods and Products.(INVIAS). CDTI project with Grup Lasem. IDI SEILA: New Technologies for an efficient, ecologic and intelligent washing system for the future textiles, CENIT CEN INSEPLATEX: Development of plastics and textiles with insect repellent and insecticide effect. LIA I+D+i CONSORCIADO, 2009 PID

6 10. FIBNATEX: Production and technical evaluation of natural fibres for the European south-western industry. INTERREG SUDOE IV B, SOE1/P1/P SAFEPROTEX: High protective clothing for complex emergency operations. FP7-NMP-2008-SME-2 project number Fellowship on Enzyme Immobilization. Talent Empresa, 2009 TEM Investigation of alternative technologies for industrial wastewater treatment. Ministry of Industry, Tourism and Trade. 15/5/ /12/09. DEX Technological transfer of new methodologies of enzymatic cotton processing in substitution of conventional methods. PET2008_ Immobilized enzymes for their use and re-use in textile processes. 2008ACOM Surface treatments to obtain antimicrobial materials IAP Modification of polyester surface using plasma and enzymatic technologies, IAP Design of bio-reactions with biocatalysts (enzymes) with application in industrial processes of the textile sector, Icrea Junior Empresa PUBLICATIONS AND ORAL COMMUNICATONS 1. A. Mª. Lozano, M. Arnautu, L. Bautista, M. de la Varga. "Textile with antimicrobial properties obtained by polymerization of bifunctional quaternary ammonium derivatives. 21st IFATCC Congress 2008, Conference, Full text paper in the Congress Proceedings, Barcelona (Spain), 7-9 May M. de la Varga. Industrial Biotechnology in textile sector, INDUSTRIAL BIOTEC 2008, Oral Communication, Brusseles (Bèlgica), June M. Garrido-Franco, Combination of enzymatic methods for the (semi)continous processing of cotton", BIOTEC 2008, Oral Communication, Granada, September M. de la Varga, M. Garrido-Franco, Biotechnological solutions for conventional cotton treatments, EXPOQUIMIA 2008, Conference, Barcelona, October R.Paul, A.Surribas, M. Brouta, M. Alaman and H. Esteve Hemp: an ecologic textile alternative. Revista Química Textil, 195: Anna Surribas, Marta Alamán, Alexandre Martínez, Marta Garrido, J. M. Botet Meritxell De la Varga. Methodologies for cotton pretreatment by enzymatic processes in substitution to conventional treatments. Revista de Química e Industria Textil, 198: A.Surribas. White Biotechnology. Learning session at the Universitat Autònoma de Barcelona. Bellaterra (Spain), 3 rd October Anna Ribé, Marolda Brouta-Agnésa, Elena Genescà, Roshan Paul. PALF: Nuevas oportunidades para la fibra de hoja de piña. Revista de Química e Industria Textil, 204: Laia Crespo, Ana Serret, Llorenç Bautista, Helena Esteve, Meritxell de la Varga, Anna Surribas, Roshan Paul. Chitosan Microspheres for Antibacterial Finishes. Full text paper in the world textile conference (Autex 2011) 10. Anna Surribas, Elena Genescà, Aleix Conesa, Roshan Paul, Marolda Brouta-Agnésa and Meritxell de la Varga. Novel industrial applications of enzymatic conversions. 9th Green Chemical Congress. Alcalà de Henares. 15th September E.Genescà White biotechnology: applications and status of the industry OCTUBREBIO 2011, Technological Center of La Rioja, Logroño (Spain), 4th October I. Forns, M. Brouta, T. Copete. Antimicrobial Fabrics Workshop at Innovation Afternoons CICLE 2011, LEITAT, Terrassa (Spain), 15th December

7 BIOINVITRO Competency Compendium Dr. María-Jesús ZURBANO Coordinator of the BioInVitro Division Main research fields: In vitro technologies, customized research for cosmetic development and claim support, in vitro ADMETOX assays, development of ready-to-use cell-based kits for in vitro ADMETOX studies. Equipments: Laminar flow hoods CO2 incubators Equipment for cell isolation Leica DM IRBE microscope, equipped with fluorescence module and Leica ACC88 digital camera Leica DMI 4000B Microscope equipped with fluorescence modules and Leica DFC 300FX digital camera Scan^R, Olympus Multiskan Ascent microplate spectrophotometer Elisa reader, SLT Lab Instruments 340 ATTC Fluoroskan Ascent FL fluorimeter Fluorimeter, Molecular Devices Spectra MAX Gemini XS Refrigerated centrifuges Lightcycler PCR 1.5, Roche Safire 2 microplate absorbance fluorescence and luminiscence reader Vertical freezer -80 ºC Spectrophotometer Shimadzu model UV-240 High Performance Liquid Chromatography Triple Quadrupole Mass spectrometry: Waters Quattro Micro Ultra Performance Liquid Chromatography Triple Quadrupole Mass spectrometry: Waters Acquity - Xevo TQ-S Ultra Performance Liquid Chromatography Q-TOF Mass spectrometry: Waters Acquity - Synapt QTOF High Performance Liquid Chromatography Q-TOF Mass spectrometry: Agilent 1100 ABSciex QSTAR Elite High Performance Liquid Chromatography UV / FLD: Waters 2795 Full access to the Science Park of Barcelona (PCB) scientific and technical platforms, and to the University of Barcelona (UB) scientific and technical services, comprising: 1) PCB: Automated Crystallography Platform, Animal Research Centre, Combinatorial Chemistry Unit, Drug Discovery Platform, Nanotechnology Platform, Polymorphism and Calorimetry Platform, Proteomics Platform, Transcriptomics Platform, Unit of Experimental Toxicology and Ecotoxicology, 2) UB: Quality Assurance Unit, Genomics Unit, Magnetic nuclear resonance Unit, Transcriptomics Unit, Proteomics Unit, Fine chemistry Unit, Peptide synthesis Unit, Nanometric Techniques Unit, Cytometry Unit, Confocal microscopy and cellular micromanipulation Unit, Electron microscopy and in situ molecular identification Unit, Separative tecnhiques Unit. 7

8 SPECIFIC RESEARCH INTERESTS Skin biology/care. The expertise of BioInVitro Division members rely on more than 10 years of experience in cell culture, molecular biology, toxicity and efficacy studies. Assays and models can cover both safety and efficacy testing of raw materials or final products. We can also provide customized research and scientific consulting to cosmetic industry. Our in vitro systems are of special value to support marketing claims to provide insights into cell molecular mechanisms. These systems are useful at early stages of product development, as an alternative to animals, and prior to in vivo assessment in human volunteers. Some of our assays include anti-aging, vitalizing, firmness, anti-oxidant effect, elasticity, anti-inflammatory effect, moisturizing, skin repair, photoprotection, reconstruction, calming effect, use of reconstructed 3D human tissues, irritation and corrosion testing, acute toxicity, citotoxicity, phototoxicity, genotoxicity, teratogenicity and skin sensitization. Studies are conducted following Good Laboratory Practices, as well as, OECD and ECVAM test procedures. ADME and toxicity. Our team can help you in your in vitro Absorption, Distribution, Metabolism and Toxicity assays following rigorous quality standards under FDA guidelines and GLP standards. We conduct in vitro models based on cells. In vitro approaches are often extremely cost-effective in comparison with in vivo studies. In vitro studies allow a lot of information to be generated within a short time and at an acceptable cost during early stages of development, as well as evaluation of new molecules and active ingredients. We provide our customer problem solving in drug metabolism to support their drug discovery and development processes using, different in vitro systems, including microsomes, systems expressing individual CYPs (recombinant microsomes and engineered cell lines) and freshly isolated hepatocytes from different species. Additionally, we offer bio-analytical support through method development and validation, in vitro bioequivalence, metabonomics and proteomics. Absorption: Intestinal barrier, skin barrier, renal barrier, blood brain barrier, transport studies (FDA Guidance and EMEA Guidelines), drug delivery and Biopharmaceutical Classification System. Distribution: Partition coefficient and Protein Binding (plasma/serum). Metabolism: Drug metabolism stability, drug clearance, drug-drug interaction (drug inhibition and induction studies on CYP450 and UGT enzymes), phenotyping of Phase I enzymes (CYP P450 enzyme mapping), quantification of Phase II metabolizing enzymes (UGT1A1, UGT1A6, UGT1A9 and UGT2B7), protein binding, adduct formation, interspecies metabolic comparison, metabolite identification and structural Q- TOF analysis, multivariate analysis for biomarker selection (PLSDA, PCA), pattern recognition in metabolomic studies (PLSDA, PCA), skin metabolism. Toxicity: Classical cell-viability assays (MTT, WST-1, NRU, LDH), acute toxicity, genotoxicity, phototoxicity, photogenotoxicity, mitochondrial toxicity (ATP balance, mitochondrial membrane potential, oxidative stress), metabolic alterations (albumin synthesis, ureogenesis, carbohydrate metabolism, intracellular calcium levels) and hepatotoxicity (general hepatotoxicity, esteatosis, toxicity mechanism identification, multiparametric assay) MOST RELEVANT PROJECTS 1. NANOTEST: Alternative Testing Strategies for the Assesment of the toxicological profile of nanoparticles used in medical diagnosis. FP7. HEALTH CARCINOGENOMICS: Development of in vitro test methods for identification of carcinogenic substances. FP6. LIFESCIHEALTH LSH ACUTETOX: Developing an in vitro test strategy sufficiently robust and powerful to completely replace in vivo testing of acute toxicity of chemicals. FP6. LIFESCIHEALTH LSH

9 4. LINTOP: Optimization of liver and intestine in vitro models for pharmacokinetic and pharmacodynamic studies. FP6. LIFESCIHEALTH LSH PUBLICATIONS 1. Quintás G et al. Chemometric approaches to improve PLSDA model outcome for predicting human nonalcoholic fatty liver disease using UPLC-MS as metabolic profiling tool. Metabolomics 2011 (in press). 2. Kuligowski J et al. Direct determination of polymerized triacylglycerides in deep-frying vegetable oil by near infrared spectroscopy using Partial Least Squares regression. Food Chemistry 2011 (in press). 3. Schroeder K et al.. Report from the EPAA workshop: In vitro ADME in safety testing used by EPAA industry sectors. Toxicol In Vitro. 25: , Vila MR et al. A new ready-to-use concept for in vitro evaluation of biotransformation-mediated toxicity (Abstract). Toxicology Letters, 2010, 196S, S37-S Gombau L et al. Assessment of the inhibition on major human CYP450 isoforms as a predictor of putative interaction on concomitantly administered drugs for a new compound under development. An activity of the Melius project (Abstract). Toxicology Letters 2010, 196S, S37-S Quintás G et al. Metabolic characterization of PB60 and PB65, two peptidomimetics which notably facilitate the transport of heparin across the intestinal barrier. An activity of the Melius project (Abstract). Toxicology Letters 2010, 196S, S37-S Gómez-Lechón MJ et al. In vitro evaluation of potential hepatotoxicity induced by drugs. Curr Pharm Des. 2010;16(17): Kuligowski J et al. Sample classification for improved performance of PLS models applied to the quality control of deep-frying oils of different botanic origins analyzed using ATR-FTIR spectroscopy. Anal Bioanal Chem Jan;399(3): Dusinska M et al. Testing strategies for the safety of nanoparticles used in medical application. Nanomedicine Aug; 4(6): Quintás G et al. Use of Fourier transform infrared spectrometry for the on-line study of focusing mechanism in capillary electrophoresis. Analytical and Bioanalytical Chemistry 2007, 387, Lahoz A et al. In Vitro ADME Medium/High-Throughput screening in drug preclinical development. Mini- Reviews in Medicinal Chemisry 6: , Gombau L et al. Polypodium leucotomos extract: antioxidant activity and disposition. Toxicol In Vitro 20:464-71, Lahoz A and Gombau L Alteraciones en la función celular por la acción de fármacos. Las ómicas: Genómica, Proteómica, Citómica y Metabolómica. Nuevas tecnologías para el desarrollo de fármacos. Chap 9. Detección de las alteraciones de la función celular en el desarrollo de nuevos fármacos. Pag , Serradell M et al. Uremic medium causes expression, redistribution and shedding of adhesion molecules in cultured endothelial cells. Haematologica Oct;87: Serradell M et al. Uremic media affects hemostatic properties of human endothelial cells in cultureand increases the production of von Willebrand factor. Nefrologia. 2002;22: Sitges M et al. Acute and mid-term combined hormone replacement therapy improves endothelial function in post-menopausal women with angina and angiographically normal coronary arteries. Eur Heart J Nov;22 (22): Gálvez A et al. Desmopressin (DDAVP) enhances platelet adhesion to the extracellular matrix ofcultured human endothelial cells through increased expression of tissue factor. Thromb Haemost May; 77 (5):

10 BIOMED Competency Compendium Dr. Francesc MITJANS Coordinator of the Biomed Division Main research fields: Cancer therapy; diagnosis, prognosis & monitoring of diseases; specialized bioservices including monoclonal antibody generation and functional activity profiling of potential drugs, compounds and extracts. Equipments: Laminar flow hoods, CO2 incubators, Roller cell culture system, Leica DMIL microscopes, one equipped with fluorescence modules and Leica DF420C digital camera, Multiskan Ascent microplate spectrophotometer, Leica RM2255 fully motorized rotary microtome & Histobath, Fluoroskan Ascent FL fluorimeter, Refrigerated centrifuges, PCR Stratagene equipment, Robotized liquid handling workstation modules, AutoMACSpro, AKTA purifier system Full access to the Science Park of Barcelona (PCB) scientific and technical platforms, and to the University of Barcelona (UB) scientific and technical services, comprising: PCB: Automated Crystallography Platform, Animal Research Centre, Combinatorial Chemistry Unit, Drug Discovery Platform, Nanotechnology Platform, Polymorphism and Calorimetry Platform, Proteomics Platform, Transcriptomics Platform, Unit of Experimental Toxicology and Ecotoxicology. UB: Quality Assurance Unit, Genomics Unit, Magnetic nuclear resonance Unit, Transcriptomics Unit, Proteomics Unit, Fine chemistry Unit, Peptide synthesis Unit, Nanometric Techniques Unit, Cytometry Unit, Confocal microscopy and cellular micromanipulation Unit, Electron microscopy and in situ molecular identification Unit, Separative tecnhiques Unit. SPECIFIC RESEARCH INTERESTS Oncology / Therapy The expertise of Biomed Division members rely on more than 15 years of experience in basic and applied oncologic research in the pharmaceutical industry arena. Some of the targets and drug candidates previously developed by our scientists are currently in phase III, II, and I oncologic clinical trials. Actually, our therapeutic focus is cancer in its broad sense and therefore represented by any of the three compartments: tumour (tumoural cells), vascular (activated endothelial cells), stromal (support cells), and also including cancer stem cells and metastatic dissemination. Recent R&D activities also include inflammation and autoimmune diseases The principal investigation activity of the team involves the identification of new oncology therapeutic targets, the validation of these targets, the generation of therapeutic agents (specially monoclonal antibodies, Mabs), the study of its mechanisms of action, and the functional characterization of these agents (monoclonals and chemical compounds) in validated in vitro & in vivo models of both tumor progression and tumor angiogenesis. Final aim is to deliver these innovative drugs as clinical development candidates (preclinical proof of principle - PoP). Diagnosis An additional goal includes the design and characterization of front-edge reagents, tools and devices (biosensors) for diagnosis, prognosis and monitoring of cancer and other diseases. 10

11 Biomed Division goal is to position itself as a reference center in theragnosis. Specialized bio-services We provide consultancy and assessment services in drug discovery programs. Based on our oncologic profiling resources we are able to provide the basis to identify unrevealed indications for known leads. We perform reprofiling/repositioning research for oncologic, inflammatory and autoimmune disorders. Additional R&D tailored research for customers and collaborations include the next technological platforms: In vitro cell models (oncology, immunology, inflammation: proliferation, viability, apoptosis, nanotox, migration, adhesion, angiogenesis, Cancer stem cells, ADCC, cytokine release, etc) In vivo animal models (oncology: singenic & xenogenic, subcutaneous & orthotopic primary tumor with cell lines and clinic explants, experimental & spontaneous metastasis, angiogenesis, noninvasive imaging; acute and chronic inflammation & pain) Preclinical histology (paraffin embedding, sectioning and standard staining) Generation of monoclonal and polyclonal antibodies for basic research, diagnosis and therapy. Monoclonal antibody engineering: chimeric, humanized and biosimilars MOST RELEVANT PROJECTS 1. VACMON: biosensor for fast vaccine monitoring. PID NANOTHER: Integration of novel NANOparticle based technology for THERapeutics and diagnosis of different types of cancer, NMP NOBITAN: Novel biofocused targeting of nucleoside analogues with cyclic RGD peptides as enhanced anticancer therapy, Eurotransbio LIFE: Comprehensive challenge to breast cancer. Cenit project DENDRIA: Soluciones innovadoras para acelerar la identificación y desarrollo de fármacos en patologías del Sistema Nervioso CENIT Project MIND: Multidisciplinary Investigation of Neurodegenerative Diseases. CENIT project. CEN ONCOLOGICA: New Strategies based on biomarkers for cancer detection, prognosis, response prediction and the development of new treatments. CENIT project. CEN NANOMOLECULAR: Contrast agent with pharmacokinetics close to clinical needs and the ability to increase the resolution of a dual-energy digital mammography. NUCLI/ACC10 project PETPRO: Development of anti-angiogenic peptides using Zera technology. NUCLI/ACC10 project with Era Biotech. RD ROBIOCAT: Robotized nanobiocharacterization station. VALTEC/ACC10 project with the Electronics Department of the UB. VALTEC Biomed Division as emergent group. AGAUR project. SGR Characterization of predictive genetic models of response to anticancer drugs: systematic personalized therapeutic intervention. CDTI project with Pangaea Biotech. 13. Formulation of docetaxel nanoparticles. CDTI project with GP Pharm ROBOCELL: Robotic Station for biocaracterizacion: system optimization and development of tools and sensors to measure interaction forces in specific biomedical applications. TEC , with the Electronics Department of the UB. 15. NANOPOLYTOX: Toxicological impact of nanomaterials derived from processing, weathering and recycling of polymer nanocomposites used in various industrial applications, NMP GENIUS: Desarrollo, consolidación y explotación de plataformas tecnológicas en el proceso de descubrimiento de medicamentos innovadores. CENIT project. CEN

12 PUBLICATIONS 1. Acero N, Braña MF, Añorbe L, Domínguez G, Muñoz-Mingarro D, Mitjans F, Piulats J. Synthesis and biological evaluation of novel indolocarbazoles with anti-angiogenic activity. Eur J Med Chem. 2012; 48: Marchán S, Pérez-Torras S, Vidal A, Adan J, Mitjans F, Carbó N, Mazo A. Dual effects of β3 integrin subunit expression on human pancreatic cancer models. Anal Cell Pathol (Amst) Oct Cupido T, Spengler J, Ruiz-Rodriguez J, Adan J, Mitjans F, Piulats J, Albericio F. Amide-to-ester substitution allows fine-tuning of the cyclopeptide conformational ensemble. Angew Chem Int Ed Engl Apr 1;49(15): Mencía N, Selga E, Rico I, de Almagro MC, Villalobos X, Ramirez S, Adan J, Hernández JL, Noé V, Ciudad CJ. Overexpression of S100A4 in human cancer cell lines resistant to methotrexate. BMC Cancer Jun 1;10: Vizán, P., S. Sánchez-Tena, G. Alcarraz-Vizán, M. Soler, R. Messeguer, M.D. Pujol, W-N. Paul Lee, M. Cascante. Characterization of the metabolic changes underlying growth factor angiogenic activation: identification of new potential therapeutic targets. Carcinogenesis. 2009; 30(6): Roca, R.Messeguer R. Genómica (2009). In: Biotechnology and Drugs. Ed. Consejo General de Colegios Oficiales de Farmacéuticos. p.p Masa M. Genómica (2009). In: Biotechnology and Drugs. Ed. Consejo General de Colegios Oficiales de Farmacéuticos. p.p Piulats J, Mitjans F. Angiogenic switch pathways" in Principles of Molecular Oncology, 2007 (3d Edition), p.p Eds: Miguel H Bronchud, MaryAnn Foote. Springer Press. New York. 9. F. Mitjans, J. Piulats. Clinical implications of basic research. Angiogenesis: target new cancer treatments. Gastroenterología y Hepatología Continuada (1): Bosch B, Clotet-Codina I, Blanco J, Pauls E, Coma G, Cedeno S, Mitjans F, Llano A, Bofill M, Clotet B, Piulats J, Este JA. Inhibition of human immunodeficiency virus type 1 infection in macrophages by an alpha-v integrin blocking antibody. Antiviral Res March; 69(3): Fernandez Y, Queralt J, PAvía X, Piera C, Ramírez de Arellano I, Mitjans F, Messeguer R, Piulats J, Carrió I. Multitracer in vivo assessment of tumor models with 18F-fluorothymidine, 18FFDG and N- ammonia PET in mice. Eur J Nucl Med Mol Imaging 2006, 33 (supl II): S Enns A, Korb T, Schluter K, Gassmann P, Spiegel HU, Senninger N, Mitjans F, Haier J. Alphavbeta5- integrins mediate early steps of metastasis formation. Eur J Cancer May; 41(7): PATENTS 1. Ciudad C, Noé V, Hernández JL, Masa M, New disrupting therapeutic technology. PCT/EP2011/ Leitat Technological Center. 2. Hernández JL, Adan J, Martínez JM, Masa M, Messeguer R, Mitjans F, Dakhel S, Coll A, Hervas R, Padilla L. Antibodies for therapeutic use, target a. EP Leitat Technological Center. 3. Hernández JL, Adan J, Martínez JM, Masa M, Messeguer R, Mitjans F, Coll A, Hervas R, Calvis C, Dakhel S. S100A4 Antibodies and Therapeutic Uses Thereof. PCT/EP2011/ Leitat Technological Center. 4. Mitjans F, Adan J, Calvis C, Lavilla R, Miguel M, Albericio F, Ruiz J. Péptidos cíclicos rgd de aminoácidos basados en tiazoles u Oxazoles como antagonistas selectivos de la integrina αvβ3. WO 2012/ A1. Leitat Technological Center. 5. Goodman S, Hahn D, Mitjans F, Adan J, Lo K-M. Engineered anti-alpha v-integrin hyibrid antibodies. International Patent nº WO 2009/ A2. Merck KGaA. Goodman S, Wilm C, Mitjans F. Antibodies for the Detection of Integrin Complexes in FFPE Material. WO Merck KGaA. 12

13 NANOHEALTH & SAFETY Competency Compendium Dr. Socorro VÁZQUEZ-CAMPOS Coordinator of NanoHealth & Safety Division Equipments: Zeta Potential (Determination of stability of colloidal dispersions) DLS (Determination of size distribution of colloids in solution) BET (Determination of the surface area and the porosity of nanoparticles) UV-Vis (Optical properties of nanoparticles and particle surface functionalization evaluation) FT-IR (Characterization for the functionalization of nanomaterials) TGA (Determination of surface functionalization of nanomaterials) DSC (Analysis of physicochemical changes as degradation, oxidation, crystallinity or melting in nanofilled matrices) ICP-MS (Quantification and detection of metallic nanoparticles) Ultrasonic horn (Dispersion of nanoparticle solutions) Electrospinning (Synthesis of polymeric and ceramic nanofibers and nanocapsules) Aging chambers (Determination of migration, release or transformation of the nanofillers exposed to defined environmental conditions) Other techniques used in external facilities (TEM, SEM, XPS, XRD, CLSM, ) Facilities and equipment for in vitro and in vivo toxicological studies Characterization techniques to determine the physical and mechanical properties of nanocomposites RESEARCH ACTIVITIES Nanotoxicology (in vitro and in vivo toxicity evaluation of nanomaterials, mechanistic studies, cell internalization studies) Evaluation of physical-chemical properties of nanomaterials included in industrial products during their life cycle (from synthesis, processing, manufacturing, use, recycling, to final disposal) Accelerated aging/ weathering of products containing NM (simulation of nanomaterials/ nanocomposites use) Determination of the release of NM from complex matrices during simulating aging processes Correlation analysis of the physical-chemical properties of nanomaterials and their toxicity Design and development of novel filtration techniques for nanomaterials based on nanofiberbased filters Design and development of novel recycling and disposal techniques for nanomaterials based on nanofiber-based filtration RA/LCA analysis of nanomaterials included in commercial products Design and development of worker protective equipment for workers manipulating nanomaterial Design and development of nanobiosensors for several applications, such as, real-time vaccine and food monitoring, disease diagnostics, explosive and gas detection Synthesis and functionalization of metallic nanoparticles for biological applications Development of nanoparticle-based drug delivery systems Design of nanoparticle-based markers to study biological processes 13

14 RESEARCH EXPERIENCE Inorganic and organic nanoparticle synthesis, and characterization Functionalization of nanoparticles through covalent and biodegradable linkages to organic molecules, biomolecules, drugs... Synthesis and characterization of smart polymeric nano and microparticles by radical polymerization to obtain porous particles of different sizes using an heterogeneous polymerization (emulsion, suspension and dispersion) Encapsulation of the drug and studies about release of therapeutic agents Multi-step synthesis, purification and characterization of organic compounds Synthesis, purification and characterization of natural products with polyheterocyclic structure Analytical Skills: HPLC purification, NMR spectroscopy, MALDI-TOF and ESI mass spectrometry, UV- Vis spectroscopy, IR, bead sorting (COPAS TM technology), Edman degradation, SPR, peptide synthesizer (Syro, MultiSynTech), Circular Dichroism, flow cytometry, SEM and SEM-FIB, CLSM, TEM, AFM and STM, XPS, ζ-potential, DLS, particle size analyzer Optimization of nanomaterial dispersion protocols and characterization of dispersions for use in (eco)toxicological studies In vitro and in vivo imaging and toxicological evaluation of nanomaterials. Cell culture, micromanipulation and microinjection in reproductive cells, biokinetic and toxicological in vivo studies Evaluation of nanomaterial cell internalization pathways Cell and biomolecules characterization by means of microelectronic and microfluidic devices MOST RELEVANT PROJECTS 1. EUROTAPES: European development of superconducting tapes: Integrating novel materials and architectures into cost effective processes for power applications and magnets, NMP ; WP leader: Life cycle assessment 2. NANOMICEX: Mitigation of risks and control of exposure in nanotechnology based inks and pigments, NMP ; WP leader: Adapted streamlined life cycle/ risk assessment of nanoparticle-based inks and pigments 3. SANOWORK: Safe nano worker exposure scenarios, NMP ; WP leader: Risk analysis 4. CERAMPOL: Ceramic and polymeric membranes for heavy metal and drug water purification, NMP , WP leader: Risk assessment of nanotechnology-based membranes during their whole life cycle 5. NEXTEC: Next generation nano-engineered thermoelectric converters. From concept to industrial validation; NMP ; WP leader: Life cycle impact assessment 6. NANOPOLYTOX: Toxicological impact of nanomaterials derived from processing, weathering and recycling of polymer nanocomposites used in various industrial applications, NMP ; Coordinator 7. VACMON: Nanobiosensor for fast vaccine monitoring. PID ; Coordinator 8. NANOSOST: Towards a sustainable, responsible and secure nanotechnology. Financed by the Ministry of Industry, Tourism and Commerce. PSE ; WP Leader: Nanotechnology-based materials for barrier applications 9. ELECTROCLAY: Development and processing of conductive nanoclays to obtain multifunctional conductive polymers. Financed by the Ministry of Industry, Tourism and Commerce (2008), IAP ; Partner: Development of PANI-based nanoclays composites for conductive applications PUBLICATIONS 1. J. Vila-Planas, E. Fernández-Rosas, B. Ibarlucea, S. Demming, C. Nogués, J. A. Plaza, C. Domínguez, S. Büttgenbach, A. Llobera. Cell analysis using a multiple internal reflection photonic lab-on-a-chip Nature Protocols 2011, 29;6(10):

15 2. M. Faccini, D. Amantia, S. Vázquez-Campos, C. Vaquero, J. M. Lopez de Ipiña, L. Aubouy. Nanofiberbased filters as novel barrier systems for nanomaterial exposure scenarios J. Phys.: Conf. Ser., 2011, 304, S. Vázquez-Campos, E. Fernández-Rosas, M. Masa, F. Mitjans, L. Aubouy. Nanopolytox: Toxicological impact of nanomaterials included in polymer nanocomposites along their life cycle. Proceedings of Modern Polymeric Materials for environmental applications. 2011, 4(2), J. M. Amigo, N. G. Bastús, R. Hoen, S. Vázquez-Campos, M. Varón, M. Royo, V. Puntes. Analysis of time-dependent conjugation of gold nanoparticles with an antiparkinsonian by using curve resolution methods Anal. Chim. Act. 2010, doi: /j.aca E. Fernandez-Rosas, R. Gómez, E. Ibañez, L. Barrios, M. Duch, J. Esteve, J. A. Plaza, C. Nogués. Internalization and cytotoxicity analysis of silicon-based microparticles in macrophages and embryos Biomedical Microdevices 2010, 12(3): E. M. Campo, M. J. Lopez Martinez, E. Fernandez, L. Barrios, E. Ibañez, C. Nogués, J. Esteve, J. A. Plaza. Focus ion beam micromachined glass pipettes for cell microinjection Biomedical Microdevices 2010, 12(2): B. Ibarlucea, E. Fernandez-Rosas, J. Vila-Planas, S. Demming, C. Nogues, J. A. Plaza, S. Büttgenbach, A. Llobera. Cell screening using disposable photonic lab on a chip systems Analytical Chemistry 2010, 82(10): W. Xu, M. Dong, H. Gersen, S. Vázquez-Campos, X. Bouju, E. Laegsgaard, I. Stensgaard, M. Crego- Cálama, D. N. Reinhoudt, T. R. Linderoth, F. Besenbacher. Exploring the transferability of large supramolecular assemblies to the vacuum-solid interface Nano Res. 2009, 2, M. J. Lopez Martinez, E. M. Campo, D. Caballero, E. Fernandez, A. Errachid, J. Esteve, J. A. Plaza. Versatile micropipette technology based on deep reactive ion etching and anodic bonding for biological applications J. Micromech. Microeng. 2009, E. Fernandez-Rosas, R. Gómez, M. Duch, J. Esteve, E. Ibañez, L. Barrios, C. Nogués, J. A. Plaza. Intracellular Polysilicon Barcodes for Cell Tracking Small 2009, 5(21): Oral and Poster Presentations ( ) 1. E. Fernández-Rosas, G. Janer, M. Busquets, V. Puntes, S. Vázquez-Campos. MWCNT polymer nanocomposites: Migration and/or release of nanoadditives in polymeric matrices during aging processes NanoImpactNet-QNano conference (Dublin), 27 February - 2 March Oral presentation. 2. E. Mas del Molino, G. Janer, E. Fernández-Rosas, R. Hernández, S. Vázquez-Campos. In vitro toxicity assessment of pristine and functionalized nanoparticles Annual IVTS Meeting (Liverpool), 8 and 9th November Oral Presentation. 3. G. Janer, E. Fernández-Rosas, R. Fernández, S. Vázquez-Campos. In vitro toxicity assessment of functionalized and aged nanoparticles. 6 th International Conference on Environmental Effects of Nanoparticles and Nanomaterials. London (United Kingdom), September Poster Presentation. 4. Socorro Vázquez-Campos. Nanosafety Cluster Meeting, Budapest (Hungary), 30 th May Oral Presentation on Outcomes of the Nanosafety Cluster meeting in Barcelona 5. Socorro Vázquez-Campos. Life Cycle Assessment of Nanomaterials in Polymer Nanocomposites: Nanopolytox approach. ENPRA Workshop: Challenges of regulation and risk assessment of nanomaterials, Ispra (Italy), May Oral Presentation. 6. Socorro Vázquez-Campos, María Blázquez. Life Cycle Analysis of Nanomaterials: An overview. Imaginenano Conference. Bilbao (Spain), April Oral Presentation. 7. Socorro Vázquez-Campos, María Blázquez. Nanosafety Cluster Meeting, Lausanne (Switzerland), 17 th February Oral Presentation on Review of WG3 activities on LCA 15

16 ANALYTICAL CHEMISTRY Competency Compendium Aleix CONESA Coordinator of Analytical Chemistry Division Equipments: ICP-MS Agilent 7500 Gas chromatography - GC-MS (with Headspace, Purge and trap, Thermal Desorption and SPME) Varian Saturn Micro CG (for Biogas analysis)- Varian 490-PRO Liquid Chromatography - HPLC-PDA - Varian ProStar - HPLC UV / FLD - Waters UPLC-SQD Waters ACQUITY - HPLC TQ: Waters 2795 Quattro Micro - UPLC-TQ - Waters Acquity -Xevo TQ-S - HPLC- Q-TOF - Agilent 1100 ABSciex QSTAR Elite - UPLC- Q-TOF - Waters Acquity - Synapt QTOF - Size Exclusion Chromatography (GPC) Agilent 1200, Varian 390-LC with Light Scatterig and Refractive Index detectors - Dionex ICS3000 (with conductivity and electrochemical detectors) Total Organic Carbon (TOC) Shimadzu V-C DCH Nitrogen Kjeldahl Buchi Kjelfelx K-360 UV-Vis (with Peltier) Shimatzu UV2450 FTIR-ATR Shimadzu Affinity Elemental Analysis EuroVector EA3000 Microwave CEM Mars Differential Scanning Calorimetry (DSC) TA Instrument Q50 Thermogravimetry (TGA) TA Instrument QS500 Karl Fisher Metrohm KF 831 Automatic Titration Chemistry laboratory Metrohm 809 Titrando and 814 USB 16

17 SPECIFIC RESEARCH INTERESTS Analytical method development and validation. Detection, quantification and valorization of high added value products from residues and feedstock: Biorefinery, algae, etc. Detection and quantification of nanoparticles. Determination of different kind of pollutants in several matrices like water, soil and others. Soil analysis. Drug quantifications in blood and other biological fluids. Waste characterization. Metal detection and quantification by ICP-MS. Chemical resistance of materials and barrier properties. REACH Assessment. Substitution of High Concern Substances: Green Chemistry. Study and definition of exposure scenarios of chemicals. Biodegradability assays (OECD official methods). Chemical analyses for ECOLABEL certification. MOST RELEVANT PROJECTS 1. BIOCONCEPT, Towards a sustainable bio-industry - Biotechnology for renewable chemicals and innovative downstream processes, KBBE ITACA, Investigación de tecnologías de tratamiento, reutilización y control para la sostenibilidad futura de la depuración de aguas, Innpronta. 3. BIOALGAL, Biological compounds obtained by microalgal innoative extraction processes, RDNET PHYLIRA, Study of malodor after washing on wet textiles. 5. FERRARID, Sustainable and high performance aggregates for 21st century. Collaborative projects of research and development destined to creat innovation nucleus, RDITCCON Development of informatics tools to support the evaluation of the chemical safety according REACH in the manufacturing packaging processes. REACH PACK, national program Call of experimental development- technological center subprograms. REA-09-AC Research on detection and control of toxic products in textile sector. Profit CT, Ministerio de Industria, Turismo y Comercio. FIT G / ECOMETRE (Ecological Metal Recovery). European Project: CIP-EIP-Eco-Innovation-2008, June 2009-November Investigation of alternative technologies for industrial wastewater treatment. Nacional Project: Ministerio de Industria, Turismo y Comercio; LIA CT Ref: DEX Treatment and waste valorization from a pharmaceutical company. Industrial Project Research in Healthy Foods and Products.(INVIAS). CDTI project with Grup Lasem. IDI NANOPOLYTOX: Toxicological impact of nanomaterials derived from processing, weathering and recycling of polymer nanocomposites used in various industrial applications, NMP , BIOLUB, Obtention of high performance and environmentally friendly lubricant bases, 09-PR Study of dyes and auxiliaries in historical textiles. 17

18 PUBLICATIONS 1. Exposición: COLORES DEL MEDITERRANEO. Colorantes naturales para un textil sostenible? del 21 de diciembre de 2010 hasta finales de Lugar: Centre de Documentació i Museu Tèxtil de Terrassa. 2. Monterrat Bargalló, Meritxell DelaVarga, Lorenzo Bautista, Albert Briz, Laurent Aubouy (November 2007). Dyes from yesterday, colours for tomorrow, Datatèxtil, 16: Aleix Conesa, Lorenzo Bautista, Roshan Paul, Laurent Aubouy, Meritxell DelaVarga. "Dyes from yesterday, colours for tomorrow: of the history to the new technologies, Datatèxtil, 19, 60-75, Leitat Technological Center. "REACH, a great challenge for industry. Pre-register time, Magazine 3G Empresarial Girona, Octubre Leitat Technological Center, Does REACH leads to residues valorization and recycling?, Revista de Plásticos Modernos, 627, September Meritxell De la Varga, Montserrat Bargalló. Dyes from yesterday, colours for tomorrow, II Mostra de Coneixement, oral communication, 19 de October 2006, Terrassa. 7. The role of the technological centres and REACH, Meritxell De la Varga, Oral communication Impacto y Gestió de REACH en la Industria workshop. Barcelona. 30 November Recommendations for SIEF constitution, Alejandra Sánchez Yagüe, Oral communication, Impacto y Gestió de REACH en la Industria workshop. Barcelona. 30 November "Obligations derived from REACH for the textile industry" workshop in the Textile Industrial Association of the Cotton Process (AITPA). Barcelona. 4 June D. Amantia. Nanoparticles release from textiles Carbon nanotube coating as experimental approach, NanoImpactNet Workshops Strategies to standardize nanomaterials for environmental and ecotoxicological research, Conference, ETH Zurich (Switzerland), 3-5 setembre Practical exercise: preregister of chemical substances", in the Informative Conference REACH: Preregister, organized by Commerce Chamber of Terrassa. 4 November 2008, Marta Escamilla, Oral Communication. 12. REACH in practise workshop "Obligations for the sector" organized by Asociación Española del Género de Punto, Natalia Fuentes. Oral Communications. Barcelona. 17 December Meritxell De la Varga, REACH in Catalonia and Technological Centres role, Oral Communication, Congress: European Chemicals Region Network / REACH Workshop, Aachen (Germany), José Moltó, Asunción Blanco, Cristina Miranda, José Miranda, Jordi Puig, Marta Valle, Meritxell DelaVarga, Carmina R Fumaz, Manuel José Barbanoj, Bonaventura Clotet. Variability in antiretroviral agents concentration in plasma among hiv-infected adults in routine clinical practice, British Journal of Clinical Pharmacology, 62, , José Moltó, Asunción Blanco, Cristina Miranda, José Miranda, Jordi Puig, Marta Valle, Meritxell DelaVarga, Carmina R Fumaz, Manuel José Barbanoj, Bonaventura Clotet, Lopinavir/Ritonavir Pharmacokinetics in HIV and Hepatitis C Virus Co-Infected Patients without Liver Function Impairment: Influence of Liver Fibrosis, Clinical Pharmacokinetics, 46, 85-92,

19 FAST MOVING CONSUMER GOODS Competency Compendium Dr. Miquel OSSET Coordinator of the FMCG Division Main research fields: Laundry & Home Care. Equipments: Hard Surface Scrub Testers Washing Machine Testing Facilities Textile Testing equipments Storage & Stability Areas Humidity & Temperature Probes Injection moulding Tensiometers and Rheometers Sun Test & Xenon aging chambers UV-climatic aging chambers Viscosimeters Optical microscopy SPECIFIC RESEARCH INTERESTS Laundry Testing: o Primary & Secondary washing performance tests o Textile testing o Wash & wear studies o Ecolabel o Physical-chemical characterizations o Stability testing Hard Surface Testing: o Scrub & Abrasion Surface Testing o Shine, foaming, easy rinse, quick & dry profiles o Optimization of formulations o New surfactants o Assessment of Hard Surface Cleaners o Stability testing Consumer Goods Product Development: o Assessment of raw materials suppliers o Soil release effects 19

20 o Competitor benchmarking o New formulations and ingredients Hygiene and Disinfection in Consumer Goods: o Disinfection & Biocides acc. to EN Norms o Hypochlorite-based formulations o Peroxide-based Laundry Additives o Long Lasting Hygiene o Corrosion and irritancy reduction o Assessment of Biocides Packaging Technologies: o Primary Packaging optimizations o Secondary Packaging optimizations o Materials Testing o Graphic & Industrial Design o Life Cycle Analysis of CPGs Consumer Packaged Goodso Carbon Footprint of CPGs Consumer Packaged Goods- R&D management in Fast Moving Consumer Goods: o R&D Strategy (OGSMs, Balance Scorecards, Roadmaps, etc...) o Management of high performance teams o R&D Financials o Key Performance Indicators for R&D o Consumer Insights MOST RELEVANT PROJECTS 1. CENIT SEILA New Technologies for an efficient, ecologic and intelligent washing system for the future textiles , CEN PET-Bleach: PET Bottles for highly oxidizing Bleaches RD EU Ecolabel. Laundry Detergents Performance testing /2009/54965/SER/G1 4. EU Ecolabel. Dishwashing Performance Testing Barcelona Institute of Packaging ( ): project management and implementation of tools & practices 6. Product Development of Biocides ( ) 7. Product Development of solid laundry additives ( ) 8. Microbiological characterization on textiles (Henkel KGaA ) 9. Characterization of Cleaners (KH-Lloreda 2010) 10. Product Development of Industrial Degreassers (Henkel KGaA ) 11. Product Development of Bleaches ( ) 12. Analytics of raw materials in detergency: on-going. 20

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