Dr WANG Ning, Michael ( 王 寧 )

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1 Dr WANG Ning, Michael ( 王 寧 ) Research Assistant Professor School of Chinese Medicine, The University of Hong Kong CONTACT INFORMATION Address: School of Chinese Medicine, 10 Sassoon Road, Pokfulam, Hong Kong Tel: (852) Fax: (852) [email protected] ACADEMIC QUALIFICATIONS 09/ /2006 Bachelor of Science in Biotechnology (Sun Yat-sen University, China) 09/ /2008 Master of Science in Pharmaceutical Science (Sun Yat-sen University, China) 09/ /2012 Doctor of Philosophy in Pharmacology (The University of Hong Kong, Hong Kong) WORK EXPERIENCE 08/ Present Research Assistant Professor, School of Chinese Medicine, The University of Hong Kong 05/ /2014 Visiting Research Fellow, School of Medicine, King s College London, UK 08/ /2015 Post-Doctoral Fellow, School of Chinese Medicine, The University of Hong Kong RESEARCH INTERESTS 1. Quality control and standardisation of Chinese herbal Medicine; 2. Molecular pharmacology of Chinese herbal Medicine in treating metabolic disorders (obesity, hepatic diseases and diabetes mellitus, etc.) and cancers; 3. Chemical profile-biological response relationship of Chinese Medicine formulas; 4. Pharmacokinetics and herbal-drug interaction of Chinese herbal Medicine; 5. Translational study and drug discovery in natural products and Chinese Medicine formula PUBLICATIONS (in chronological order, Citation record from Google Scholar) [1] Wang X, Wang N, Cheung F, Lao L, Li C, Feng Y. Chinese medicines for prevention and treatment of human hepatocellular carcinoma: current progress on pharmacological actions and mechanisms. J Integr Med (3): [2] Wang L, Wang N, Tan H, Zhang Y, Feng Y. Protective Effect of a Chinese Medicine Formula He-Ying-Qing-Re Formula on Diabetic Retinopathy. J Ethnopharmacol Apr

2 27. pii: S (15) doi: /j.jep (IF:2.939) [3] Wang N, Feng Y, Tan HY, Cheung F, Hong M, Lao L, Nagamatsu T. Inhibition of eukaryotic elongation factor-2 confers to tumor suppression by a herbal formulation Huanglian-Jiedu decoction in human hepatocellular carcinoma. J Ethnopharmacol ;164: (IF:2.939) [4] Wang N, Feng Y. Elaborating the Role of Natural Products-Induced Autophagy in Cancer Treatment: Achievements and Artifacts in State-of-Art. Biomed Res Int. 201: (IF:2.706) [5] Wang X, Feng Y, Wang N, Cheung F, Tan HY, Zhong S, Li C, Kobayashi S. Chinese Medicines Induce Cell Death: The Molecular and Cellular Mechanisms for Cancer Therapy. Biomed Res Int. 2014: (IF:2.706) [6] Wang N, Feng Y, Cheung F, Wang X, Zhang Z, Feng Y. A Chinese Medicine Formula Gegen Qinlian Decoction Suppresses Expansion of Human Renal Carcinoma With Inhibition of Matrix Metalloproteinase-2. Integr Cancer Ther Sep 15. pii: [Epub ahead of print] (IF:2.014) [7] Wang N, Zhu M, Wang X, Tan HY, Tsao SW, Feng Y. Berberine-induced tumor suppressor p53 up-regulation gets involved in the regulatory network of MIR-23a in hepatocellular carcinoma. Biochim Biophys Acta-Gene Regulatory Mechanism : (IF:5.440) [8] Tian Y, Teng LR, Song JJ, Meng QF, Lu JH, Zhang WW, Wei K, Wang N, Wang D, Teng LS. Studies on the analgesic activities of Jia-Yuan-Qing pill and its safety evaluation in mice. Protoplasma : (IF:3.171) [9] Xu B, Wang N, Pan W, Qiu J, Cao P, Zhu M, Feng Y, Liang G. Synthesis and anti-tumor activity evaluation of Matijin-Su derivatives. Bioorg Chem : (IF:2.141, co-first author) [10] Wang N, Zhu M, Tsao SW, Man K, Zhang Z, Feng Y. MiR-23a-mediated inhibition of topoisomerase 1 expression potentiates cell response to etoposide in human hepatocellular carcinoma. Mol Cancer :119. (IF:5.397, Citation:8) [11] Tan HY, Wang N, Tsao SW, Zhang Z, Feng Y. Suppression of vascular endothelial growth factor via inactivation of eukaryotic elongation factor 2 by alkaloids in Coptidis rhizome in hepatocellular carcinoma. Integr Cancer Ther : (IF:2.014) [12] Wang N, Feng Y, Zhu M, Siu FM, Ng KM, Che CM. A novel mechanism of XIAP degradation induced by timosaponin AIII in hepatocellular carcinoma. Biochim Biophys Acta-Molecular Cell Research : (IF:5.297, Citation:4) [13] Cheung F, Wang X, Wang N, Yuen MF, Ziea TC, Tong Y, Wong VT, Feng Y. Chinese Medicines as an Adjuvant Therapy for Unresectable Hepatocellular Carcinoma during Transarterial Chemoembolization: A Meta-Analysis of Randomized Controlled Trials. Evid Based Complement Alternat Med. 2013: (IF:2.175, Citation:3) [14] Wang N, Feng Y, Cheung F, Chow OY, Wang X, Su W, Tong Y. A comparative study on the hepatoprotective action of bear bile and Coptidis Rhizoma aqueous extract on experimental liver fibrosis in rats. BMC Complement Altern Med :239. (IF:1.877, Citation:6) [15] Wang N, Zhu M, Tsao SW, Man K, Zhang Z, Feng Y. Up-regulation of TIMP-1 by genipin inhibits MMP-2 activities and suppresses the metastatic potential of human hepatocellular

3 carcinoma. PLoS One :e (IF:3.534, Citation:16) [16] Wang XB, Feng Y, Wang N, Cheung F, Wong CW. Recent progress on anti-liver fibrosis candidates in patents of herbal medicinal products. Recent Patent Food Nutrition Agriculture : (Citation:10) [17] Cheung F, Feng Y, Wang N, Yuen MF, Tong Y, Wong VT. Effectiveness of Chinese herbal medicine in treating liver fibrosis: a systematic review and meta-analysis of randomized controlled trials. Chine Med :5. (IF:2.340, Citation:5) [18] Feng Y, Wang N, Ye X, Li H, Feng Y, Cheung F, Nagamatsu T. Hepatoprotective effect and its possible mechanism of Coptidis rhizoma aqueous extract on carbon tetrachloride-induced chronic liver hepatotoxicity in rats. J Ethnopharmacol : (IF:2.939, Citation:52) [19] Wang N, Zhu M, Tsao SW, Tong Y, Feng Y. Tumor necrosis factor-a up-regulates the microrna-21 expression and promotes cell migration in human hepatocellular carcinoma cells MHCC97-L. Int J Cancer , Suppl 1, 38. (IF:5.007, supplement issue) [20] Zhu M, Wang N, Tsao SW, Tong Y, Feng Y.3Alpha,7beta-dihydroxy-5 beta-cholan-24-oic acid N-(2-sulfoethyl)amide alters the micrornas expression and promotes cell migration of human hepatocellular carcinoma cells. Int J Cancer , Suppl 1, 39. (IF:5.007, supplement issue) [21] Feng Y, Wang N, Zhu M, Feng Y, Li H, Tsao S. Recent progress on anticancer candidates in patents of herbal medicinal products. Recent Patents on Food, Nutrition & Agriculture : (Citation:24) [22] Wang N, Pan W, Zhu M, Hao X, Zhang M, Liang G, Feng Y*. Fangchinoline induces autophagic cell death via p53/sestrin2/ampk signaling in human hepatocellular carcinoma cells. Br J Pharmacol, 2011, 164: (IF:4.990, Citation:27) [23] Zhu M, Wang N, Tsao SW, Yuen MF, Feng Y, Wan TS, Man K, Feng Y. Up-regulation of micrornas, mir21 and mir23a in human liver cancer cells treated with Coptidis rhizoma aqueous extract. Exp Ther Med : (IF:0.941, Citation:17) [24] Wang N, Feng Y, Xie T, Su W, Zhu M, Chow OY, Zhang Y, Ng, KM, Leung CH, Tong Y. Chemical and biological analysis of active free and conjugated bile acids in animal bile using HPLC-ELSD and MTT methods. Exp Ther Med : (IF:0.941, Citation:4) [25] Wang N, Feng Y, Zhu M, Tsang CM, Man K, Tong Y, Tsao SW. Berberine induces autophagic cell death and mitochondrial apoptosis in liver cancer cells: the cellular mechanism. J Cell Biochem, : (IF:3.368, Citation:77) [26] Wang N, Feng Y, Lau EP, Tsang C, Ching Y, Man K, Tong Y, Nagamatsu T, Su W, Tsao S. F-actinreorganization and inactivation of rho signaling pathway involved in the inhibitory effect of Coptidis Rhizoma on hepatoma cell migration. Integr Cancer Ther, : (IF:2.014, Citation: 27) [27] Feng Y, Siu KY, Ye X, Wang N, Yuen MF, Leung CH, Tong Y, Kobayashi S. Hepatoprotective effects of berberine on carbon tetrachloride-induced acute hepatotoxicity in rats. Chin Med ;5:33. (IF:2.340, Citation: 24) [28] Feng Y, Cheung KF, Wang N, Liu P, Nagamatsu T, Tong Y. Chinese medicines as a resource for liver fibrosis treatment. Chin Med ;4:16. (IF:2.340, Citation: 23) [29] Wang N, Wang Y, Li P, Peng W, Xie T, Feng Y, Su W. The Bioavaliability of

4 Hepatoprotective Flavoniods in Hypericum Japonicum Extract. Journal of Bioanalysis & Biomedicine :33-8 (Citation:2) [30] Tang J, Feng Y, Tsao S, Wang N, Curtain R, Wang Y. Berberine and Coptidis rhizoma as novel antineoplastic agents: a review of traditional use and biomedical investigations. J Ethnopharmacol :5-17. (IF:2.939, Citation:216) [31] Guan S, Su W, Wang N, Li P, Wang Y. Effects of radix polygoni multiflori components on tyrosinase activity and melanogenesis. J Enzyme Inhib Med Chem : (IF:2.383, Citation:2) [32] Guan S, Su W, Wang N, Li P, Wang Y. A potent tyrosinase activator from Radix Polygoni multiflori and its melanogenesis stimulatory effect in B16 melanoma cells. Phytother Res : (IF:2.397, Citation:15) [33] Feng Y, Siu K, Wang N, Ng KM, Tsao SW, Nagamatsu T, Tong Y. Bear bile: dilemma of traditional medicinal use and animal protection. J Ethnobi and Ethnomed. 2009, 5:2 (1-9). (IF:1.978, Citation:39) [34] Wang N, Li P, Wang Y, Peng W, Wu Z, Tan S, Liang S, Shen X, Su W. Hepatoprotective effect of Hypericum japonicum extract and its fractions. J Ethnopharmacol, :1-6. (IF:2.939, Citation: 40) CONFERENCE ABSTRACT [1] Wang N, Tan HY, Feng Y. Experimental evidence of the pharmacylogical activety of Huanglian-containing Chinese Medicine formula in treating cancer on ICICM 2015, August 2015, Hong Kong, China. [2] Wang N, Tan HY, Feng Y. Suppression of nascent protein synthesis by natural product berberine on 19th World Congress on Advances in Oncology & 17th International symposium on Molecular Medicine, October, 2014, Athens, Greece. [3] Wang N, Feng Y. The anti-metastatic effect of genipin, a natural product in Gardnia Kasminoides Ellis on hepatocellular carcinoma and its underlying mechanism. 11th Meeting of the Consortium for Globalization of Chinese Medicine (CGCM). August, 2013, Graz, Austria. [4] Wang N and Feng Y, Comparison on the therapeutic action of coptis and bear bile on experimental liver fibrosis, 4th World Congress on Bioavailability Summit, May 2013, Beijing, China. [5] Wang N and Feng Y, Differential inhibitory effect of berberine on human hepatocellular carcinoma, The 8th international postgraduate symposium on Chinese medicine. August 2012, Hong Kong, China. [6] Wang N and Feng Y, The anti-metastatic potential of Gegen Qinlian Decoction in human renal carcinoma and its underlying mechanism, 11th Meeting of the Consortium for Globalization of Chinese Medicine (CGCM). August 2012, Macau, China. [7] Wang N, Zhu M, Tsao SW, Tong Y, Feng Y. Tumor necrosis factor-a up-regulates the microrna-21 expression and promotes cell migration in human hepatocellular carcinoma cells MHCC97-L. 1st Excellence in Oncology, Novmember 2010, Athens Greece. [8] Wang N, Pan W, Zhu M, Zhang M, Hao X, Liang G, Feng Y, Fangchinoline is a potential anti-cancer drug by inducing autophagic cell death in heaptocellular carcinoma

5 cells, 10th Meeting of Consortium for Globalization of Chinese Medicine (CGCM), August, 2011, Shanghai, China. [9] Wang N, Zhu M, Tong Y, Tsao SW, Feng Y. Type1 and type 2 cell deaths on anti-tumor effect of berberine in liver cancer cells. 9th Meeting of Consortium for Globalization of Chinese Medicine (CGCM), August, 2010 Hong Kong, China [10] Wang N, Feng Y, Tang J, Tsao SW, Tong Y. The anti-tumor action of coptidis rhizome and its major compound berberine: ancient drug with novel use. 5th International Congress on Complementary and Alternative Medicine, May, 2010, Tromsø, Norway. BOOK CHAPTER 1. Feng Y, Chan H, Wang N, Zhu M, Cheung F, Hong M. MIR23A (microrna 23a) Atlas Genet Cytogenet Oncol Haematol. 2013;17(12): Electronic database by INIST-CNRS 2. Feng YG, Wang N, Chueng F, Zhu M, Li H, Feng Y. Molecular and Cellular Mechanism Studies on Anticancer Effects of Chinese Medicines. Chapter in Biomedical Engineering, Trends, Research and Technologies (pp ). ISBN , pp Feng Y, Chen XM, Wang N and Shen JG. Current Progress on Medicinal Plants and their Biological Properties in Contemporary China (Around 20,000 words). Chapter in Recent Progress in Medicinal Plants Vol. 28: Ethnomedicine: Source & Mechanism-II. Studium Press LLC, USA. 2010, pp PATENTS 1. Pan W, Feng Y, Liu Y, Wang N, Huang L, Liang G, et al. Chinese Patent Application No X filed 18 August Feng Y, Wang N. Chinese Patent Application No filed 27 July 2010 Title: The New Use of Coptidis Rhizoma Total Alkaloids. Update: June 2016