Nian Gong, PhD. Department of Anesthesiology & Perioperative Care

Transcription

1 Nian Gong, PhD Department of Anesthesiology & Perioperative Care University of California, Irvine 837 Health Sciences Road, Gillespie Building 3226A, Irvine, CA Telephone/Fax: (949) ; Website: EDUCATION PhD, Pharmacology, 2013 Shanghai Jiao Tong University, Shanghai, China BSc, Pharmacy, 2007 Xiang Tan University, Xiangtan, Hunan, China WORK EXPERIENCE Post-Doctoral Research Fellow Department of Anesthesiology & Perioperative Care University of California, Irvine Irvine, California present Research Assistant and Assistant Lab Manager King s Lab School of Pharmacy Shanghai Jiao Tong University Shanghai , China Website: AWARDS AND HONORS The 19 th Technology Innovation Cup, Shanghai Association of Inventions, 2013 Young Scientist Best Paper Award, Shanghai Pharmacological Society, 2013 Excellent Poster Award, The 12 th Pharmacologists, 2013 Meeting of the Asia Pacific Federation of National Scholarship for Graduate Students, 2012 Predoctoral Fellowship of Shanghai Jiao Tong University, 2012

2 Scholarship for Excellent Doctoral Student of Ministry of Education, 2011 Predoctoral Fellowship of Shanghai Jiao Tong University, 2011 Predoctoral Fellowship of Shanghai Jiao Tong University School of Pharmacy, 2011 Best Poster Award, The 9 th IASP Research Symposium Understanding Mechanisms of Chronic Pain, 2011 Best Poster Award, Chinese Pharmacological Society, Graduate Innovative Ability Fund of Shanghai Jiao Tong University, 2011 Young Scientist Best Paper Award, Shanghai Pharmacological Society, 2010 PUBLICATIONS Patents 3. Wang, Y.-X. & Gong N. (2011). Inhibitors of DAAO are used for the prevention and/or revision of opioids tolerance ; PCT/CN2012/074062; WO 2012/ Wang Y.-X. & Gong N. (2011). Agonists of GLP-1 receptors are used for the treatment of pain ; WO/2012/ Xu M., Wang Y.-X., Zhang Y.-H., Luo X.-S., Gong N. Zhang L-J. & Zhou X.-J. (2009). New Exendin analogs and their PEGylated derivatives. CN /PCT/CB2010/ Peer-reviewed articles 16. Zhu B., Gong N. (co-first author), Fan H., Peng C.-S., Ding X.-J., Jiang Y. & Wang Y.-X. (2014). Lamiophlomis rotata, an orally available Tibetan herbal painkiller, specifically reduces pain hypersensitivity through the activation of the spinal glucagon-like peptide-1 receptors. Anesthesiology, in press. 15. Gong N., Fan H., Ma A.-N., Xiao Q. & Wang Y.-X. (2014). Geniposide and its iridoid analogs exhibit antinociception by acting at the spinal GLP-1 receptors. Neuropharmacology 84: Gong N., Xiao Q., Zhu B., Zhang C.-Y., Wang Y.-C., Han H., Ma A.-N. & Wang Y.-X. (2014). Activation of spinal glucagon-like peptide-1 receptors specifically suppresses pain hypersensitivity. J. Neurosci. 34: Gong N., Li X.-Y., Xiao Q. & Wang Y.-X. (2014). Identification of a novel spinal dorsal horn astroglial D-amino acid oxidase-hydrogen peroxide pathway involved in morphine antinociceptive tolerance. Anesthesiology 120: Wang Y.-C., Lu J.-M., Jin H.-Z., Ma A.-N., Zhang J.-Y., Gong N., Xiao Q., Zhu B., Lv Y.-F., Yu N., Zhang W.-D. & Wang Y.-X. (2014). Beneficial effects of natural

3 Jeju groundwaters on lipid metabolism in high-fat diet-induced hyperlipidemic rats. Nutrition Research & Practice 8: Zhang J.-Y., Gong N., Huang J.-L., Guo L.-C. & Wang Y.-X. (2013). Gelsemine, a principle alkaloid from Gelsemium sempervirens Ait., exhibits potent and specific antinociception in chronic pain by acting at spinal α3 glycine receptors. Pain 154: Wei H., Gong N. (co-first author), Huang J.-L., Fan H., Ma A.-N., Li X.-Y., Wang Y.-X. & Pertovaara A. (2013). Spinal D-amino acid oxidase contributes to mechanical pain hypersensitivity induced by sleep deprivation in the rat. Pharmacol. Biochem. Behav. 111: Ma A.-N., Gong N., Lu J.-M.,Huang J.-L., Hao B., Guo Y., Zhong J., Xu Y., Chang J. & Wang Y.-X. (2013). Local protective effects of oral 45S5 bioactive glass on gastric ulcers in experimental animals. J. Mat. Sci.: Mat. Med. 24: Gong N., Wang Y.-C., Wang H.-L., Ma A.-N., Hashimoto K. & Wang Y.-X. (2012). Interactions of the potent D-amino acid oxidase inhibitor CBIO with morphine in pain and tolerance to analgesia. Neuropharmacology 63: Wang Y.-X., Gong N., Xin Y.-F., Hao B., Zhou X.J. & Pang C.C.Y. (2012). Biological implications of oxidation and unidirectional chiral inversion of D-amino acids. Current Drug Metabolism 13: Lu J.-M., Gong N., Wang Y.-C. & Wang Y.-X. (2012). D-Amino acid oxidase-mediated increase in spinal hydrogen peroxide is mainly responsible for formalin-induced tonic pain. Br. J. Pharmacol.165: Wei H., Huang J.-L., Hao B., Wang Y.-C., Nian G., Ma A.-N., Li X.-Y., Wang Y.-X. & Pertovaara A. (2011). Intrathecal administration of antioxidants attenuates mechanical pain hypersensitivity induced by REM sleep deprivation in the rat. Scandinavian J. Pain 2: Gong N., Ma A.-N., Zhang L.-J., Lu X.-S., Zhang Y.-H., Xu M. & Wang Y.-X. (2011). Site-specific PEGylation of exenatide analogues markedly improved their glucoregulatory activity. Br. J. Pharmacol. 163: Gong N., Gao Z.-Y., Wang Y.-C., Li X.-Y., Huang J.-L., Hashimoto K. & Wang Y.-X. (2011). A series of D-amino acid oxidase inhibitors specifically prevent and reverse formalin-induced tonic pain in rats. J. Pharmacol. Exp. Ther. 336: Xin Y.-F., Li X., Hao B., Gong N., Sun W.-Q., Konno R. & Wang Y.-X. (2010). Indispensable but insufficient role of renal D-amino acid oxidase in chiral inversion of N G -nitro-d-arginine. Chem. Biodivers. 7: Zhang W.B., Gong N. & Wang Y.-X. (2010). Renal SGLT2 inhibitors: a new class of oral hypoglycemic agents. Progress in Physiological Science 41: Conference Abstracts 20. 樊 惠, 龚 念, 李 腾 飞, 马 爱 妞, 王 明 伟, 王 永 祥 (2014) 小 分 子 GLP-1 受 体 激 动 剂 WB4-24 通 过 促 进 β- 内 啡 肽 释 放 抑 制 炎 性 疼 痛 全 国 第 五 次 麻 醉 药 理 学 学 术 会 议, 河 南, 郑 州 会 议 摘 要 : Zhang J.-Y., Gong N., Huang J.-L., Guo L.-C. & Wang Y.-X. (2013). Gelsemine, a principle alkaloid from Gelsemium sempervirens Ait., exhibits potent and specific analgesia in chronic pain by acting at spinal α3 glycine receptors. The 12 th Meeting

4 of the Asia Pacific Federation of Pharmacologists. Shanghai, China. Acta Pharmacologica Sinica 34 (Suppl.): Lu J, Xei D.-S., Li T.-F, Wang Y.-C., Cui J.-J, Xie J., Gong N., Fu L. & Wang Y.-X. (2013). Discovery of a potent and orally-available D-amino acid oxidase inhibitor for the management of chronic pain. The 12 th Meeting of the Asia Pacific Federation of Pharmacologists. Shanghai, China. Acta Pharmacologica Sinica 34 (Suppl.): Xiao Q., Gong N. & Wang Y.-X. (2013). Exenatide given intrathecally produces efficacious diuretic effect. The 12 th Meeting of the Asia Pacific Federation of Pharmacologists. Shanghai, China. Acta Pharmacologica Sinica 34 (Suppl.): Gong N., Li X.Y. Xiao Q. & Wang Y.-X. (2013). Identification of a novel spinal dorsal horn astroglial D-amino acid oxidase-hydrogen peroxide pathway involved in morphine analgesic tolerance. The 12 th Meeting of the Asia Pacific Federation of Pharmacologists. Shanghai, China. Acta Pharmacologica Sinica 34 (Suppl.): Chen Y., Gong N. & Wang Y.-X (2013). Methylglyoxal, an endogenous aldehyde formed in diabetes, induces nociception by activation of peripheral TRPA1 receptors. The 12 th Meeting of the Asia Pacific Federation of Pharmacologists. Shanghai, China. Acta Pharmacologica Sinica 34 (Suppl.): Gong N., Li X.Y. & Wang Y.X. (2012) Spinal DAAO/H2O2 pathway contributes to the development of morphine tolerance to analgesia. 15 th National Conference Neuropsychopharmacology, Zhangjiakou, Hebei, China. Chin. J. Pharmacol. Toxicol. 26: Zhu B., Gong N., Peng C.S., Jiang Y. & Wang Y.X. (2012) Iridoid glycosides, the active ingredients of lamiophlomis rotata (benth.) kudo, exhibits efficacious analgesia in chronic pain. 15 th National Conference Neuropsychopharmacology, Zhangjiakou, Hebei, China. Chin. J. Pharmacol. Toxicol. 26: Zhang J.-Y., Huang J.-L., Gong N. & Wang Y.-X. (2011). Gelsemine, a potent alkaloid from Gelsemium elegans, exhibits efficacious analgesia in chronic pain by activation of spinal glycine receptors. The 9 th IASP Research Symposium Understanding Mechanisms of Chronic Pain. Shanghai, China. Abstract: Gong N., Zhang C.-Y., Wang Y.-C. & Wang Y.-X. (2011). Activation of spinal glucagon-like peptide-1 receptors produces efficacious analgesia in chronic pain. The 9 th IASP Research Symposium Understanding Mechanisms of Chronic Pain. Shanghai, China. Abstract: Ma A.N., Gong N., Lu J.M., Huang J.L., Hao B. & Wang Y.-X. (2011). Local protective effects of oral 45S5 bioactive glass on gastric ulcers in experimental animals. 11 th National Conference of the Chinese Pharmacological Society, Jinan, Shandong, China. Chin. J. Pharmacol. Toxicol. 25 (Suppl.): Gong N., Wang Y.-C., Wang H.-L. & Wang Y.-X. (2011). Interactions of CBIO, an inhibitor probe of D-amino acid oxidase, with morphine in pain. 11 th National Conference of the Chinese Pharmacological Society, Jinan, Shandong, China. Chin. J. Pharmacol. Toxicol. 25 (Suppl.): Wang Y.-X. & Gong N. (2011). GLP-1 receptors in the spinal cord mediate analgesia without producing tolerance in neuropathic pain and cancer pain. 11 th National Conference of the Chinese Pharmacological Society, Jinan, Shandong, China. Chin. J. Pharmacol. Toxicol. 25 (Suppl.):54-55.

5 7. Wang Y.-X., Gong N., Chen X.-L., Huang J.-L., Wang Y.-C., Li X.-Y. & Ma A.-N. (2011). Pain biology of spinal D-amino acid oxidase (DAAO). 12 th International Congress on Amino Acids, Peptides and Proteins. Beijing, China. Amino Acids 41:S19. 6.Gong N., Gao Z.-Y., Wang Y.-C., Li X.-Y., Huang J.-L., Hashimoto K. & Wang Y.-X. (2010). A series of DAO inhibitors specifically prevent and reverse formalin-induced tonic pain annual Meeting of Shanghai Pharmacological Society, Shanghai, China. 5.Gong N., Wang Y.-C., Zhang H.H., Wang H.L. & Wang Y.-X. (2010). Analgesic pharmacological studies of orally effective CBIO, a potent D-amino acid oxidase inhibitor. 14 th National Conference Neuropsychopharmacology, Nanjing, Jiangsu, China. Chin. J. Pharmacol. Toxicol. 24: Lu J.M., Gong N. & Wang Y.-X. (2010). D-Amino acid oxidase-mediated increase in spinal hydrogen peroxide is mainly responsible for formalin-induced tonic pain. 14 th National Conference Neuropsychopharmacology, Nanjing, Jiangsu, China. Chin. J. Pharmacol. Toxicol. 24: Wang Y.-C., Gong N. & Wang Y.-X. (2010). A improved D-amino acid oxidase inhibitor screening methods. 14 th National Conference Neuropsychopharmacology, Nanjing, Jiangsu, China. Chin. J. Pharmacol. Toxicol. 24: Wang Y.-X., Gong N., Gao Z.-Y. & Huang, J.-L. (2010). Discovery and characteristics of inducible spinal D-amino acid oxidase as a novel target for the treatment of chronic pain. WorldPharma2010, Copenhagen, Denmark. Basic Clin. Pharmacol. Toxicol. 107: Gong N., Zhang L.J., Ma A.N., Huang J.L., Xu M. & Wang Y.-X. (2009). Site-specific PEGylation of exenatide analogues markedly improved their glucoregulatory activity. 10 th National Conference of the Chinese Pharmacological Society, Tianjing, China. Chinese Pharmacological Bulletin 25:204.