Histological definition of a lymph node - based on a survey among Danish pathologists

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1 1 O1-1 Histological definition of a lymph node - based on a survey among Danish pathologists Agnete Riisgaard Sørensen (1), Astrid Petersen (1). (1)Department of Pathology, Aalborg University Hospital, Aalborg, Denmark. O1-2 Processing times for gastrointestinal biopsies with suspected malignancy can be reduced by a simple intervention Tina Prangsgaard (1+2) Ulla Engel (1). (1) Hvidovre University Hospital, Department of Pathology, Hvidovre, Denmark, (2) Department of Pathology, Herlev Hospital, Denmark O1-3 Validation of automated image analysis on HER2 expression in breast cancer Henrik Holm Rossing (1), Martin Kristensson (2), Maj-Lis Møller Talman (1), Ben Vainer (1). (1) Department of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark. (2) Visiopharm, Hoersholm, Denmark. O1-4 The influence of preoperative chemo-radiotherapy on lymph node yield, N-status and survival in rectal cancer Results from a nationwide cohort study Jakob Lykke M.D (1)., Per Jess M.D., DMSci(2) and Ole Roikjaer M.D(2) On behalf of the Danish Colorectal Cancer Group. (1)Department of Surgery, Slagelse Hospital, University of Copenhagen, Faelledvej 1, 4200 Slagelse, Denmark. (2)Department of Surgery, Roskilde Hospital, University of Copenhagen, Koegevej 7-13, Roskilde, Denmark. O1-5 Repeated biopsies in prostate cancer patients on active surveillance: clinical implications of interobserver variation in histopathological assessment Frederik B. Thomsen(1), Niels Marcussen(2), Kasper Drimer Berg(1), Klaus Brasso(1), Ib Jarle Christensen(3), Ben Vainer(4), Peter Iversen(1) 1) Copenhagen Prostate Cancer Center, Department of Urology, Rigshospitalet; Department of Clinical Medicine, Faculty of Health and Medical Sciences, University of Copenhagen 2) Department of Clinical Pathology, Odense University Hospital, University of Odense. O1-6 Post-operative multi-disciplinary team meeting have a positive effect on the surgical quality in colon cancer Ditte Louise E. Munkedal (1) Nicholas P. West (2) Lene H. Iversen (1) Rikke Hagemann-Madsen (3) Philip Quirke (2) Søren Laurberg (1). (1)Department of Surgery P, Aarhus University Hospital, Aarhus, Denmark, (2)Pathology, Anatomy and Tumour Biology, Leeds Institute of Cancer and Pathology, School of Medicine, University of Leeds, Leeds,

2 2 United Kingdom, (3)Pathology Department, Aarhus University. O1-7 Utility of anti-phosphohistone H3 (PHH3) immunreactivity to determine mitotic rate in gastrointestinal stromal tumours an interobserver variability study Iordache A, Jensen MB, Woller NC, Langhoff JL, Toxværd A, Riis LB (1)Department of Pathology, Herlev Hospital O1-8 Influence of reduction formalin fixation time on the quality of histomorphology and lymph node retrieval in Colorectal Cancer Ban A. Abdulwahab (1), Ulla Engel (1), Mahin Mohammadi (1). (1) Hvidovre University Hospital, Department of Pathology, Hvidovre, Denmark O1-9 Early colorectal cancer mirna profile Anne-Marie Kanstrup Fiehn (1), Gro Linno Willemoe (1), David Hebbelstrup Jensen (2), Ben Vainer (1) (1)Department of Pathology, Rigshospitalet, Copenhagen, Denmark, (2)Department of Otorhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen, Denmark O2-1 The prevalence of HPV in a screening population of 2965 women aged years in Southern Jutland and Fyn. Comparison of the Cobas HPV Assay, Roche and the Hybrid Capture 2 Test, Qiagen Dorthe Ørnskov (1) Marianne Waldstrøm (1,2) (1)Department of Pathology, Vejle Hospital, Denmark (2) Institute of Regional Health Research, University of Southern Denmark. O2-2 Is rapid rescreening of cervical cytology samples worth the effort? Dorthe Ejersbo (1), Marianne Waldstrøm(1,2) (1)Department of Pathology, Vejle Hospital, Denmark (2) Institute of Regional Health Research, University of Southern Denmark. O2-3 Comparison of four HPV assays in a primary screening population on women 30 years of age Rebolj M (1), Ejegod D (2,3), Preisler S (2,3), Rygaard C (2), Lynge E (1), Bonde J (2,3) (1)University of Copenhagen, Department of Public Health, Copenhagen, Denmark, (2)Hvidovre University Hospital, Department of Pathology, Hvidovre, Denmark, (3)Hvidovre University Hospital, Clinical Research Centre, Hvidovre, Denmark. O2-4 Detection of high-grade CIN by four HPV assays in women with abnormal cytology Bonde J (1,2), Rebolj M (3), Preisler S (1,2), Ejegod D (1), Lynge E (3), Rygaard C (1)

3 3 (1)Hvidovre University Hospital, Department of Pathology, Hvidovre, Denmark, (2)Hvidovre University Hospital, Clinical Research Center, Hvidovre, Denmark, (3)University of Copenhagen, Department of Public Health, Copenhagen, Denmark. O2-5 The Aptima HPV mrna Assay is as sensitive but more specific than the Linear Array HPV DNA Test for post-treatment surveillance Marianne Waldstrøm (1,2), Dorthe Ørnskov (1) (1)Department of Pathology, Vejle Hospital, Denmark (2) Institute of Regional Health Research, University of Southern Denmark. O2-6 HPV test by use of RNA method in cervical cytology Sofie Hansen (1), Susanne Merete Nielsen (1), Karsten Nielsen (1) (1)Department of Pathology, Naestved Hospital and Institute of Regional Health Research, University of Southern Denmark O2-7 HPV-findings in women + 60 years old Susanne M. Nielsen (1), Karsten Nielsen (1,2) (1) Department of Pathology, Naestved Hospital, (2)Institute of Regional Health Research, Odense O2-8 Detection of HPV in anal cancer and low rectal cancer Jan Lindebjerg (1), Marianne Waldstrøm (1,2), Dorthe Ørnskov (1) (1)Department of Pathology, Vejle Hospital, Denmark (2) Institute of Regional Health Research, University of Southern Denmark. O2-9 A study on Interobserver Reproducibility in Diagnosis of Endometrial Carcinoma BH Winberg(1), VR Skovlund(1,) E Høgdall (1), IJ Christensen (2), M Lidang(1) (1)Dept. Pathology, Herlev Hospital, Denmark, (2)Finsen Laboratory, Copenhagen, Denmark. Tissue Micro Array in order to evaluate the improvement of the diagnosis of endometrial carcinoma. O3-1 c-kit expression in cutaneous melanoma Johanne Lade-Keller (1), Rikke Riber-Hansen (1), Christina Dahl (2), Per Guldberg (2), Henrik Schmidt (3) Stephen Hamilton-Dutoit (1), Torben Steiniche (1) (1)Institute of Pathology, Aarhus University Hospital, Aarhus, Denmark, (2)Danish Cancer Society Research Center, Copenhagen, Denmark, (3)Department of Oncology, Aarhus University Hospital, Aarhus, Denmark. O3-2

4 4 A stereological approach to immunohistochemical differentiation between Spitz nevi and malignant melanomas Suku MLH (1), Sørensen FB (2), Sørensen S (3), Pakkenberg B (3), Hastrup N (1), Henrik-Nielsen R (1), Gjerdrum LMR (1). (1)Department of Pathology, Rigshospitalet, Denmark (2)Department of Pathology, Vejle Sygehus, Denmark (3)Research Laboratory for Stereology and Neuroscience, Bispebjerg Hospital, Denmark. O3-3 Cell of origin as a possible predictive marker for response to treatment with R-CHOEP in young high-risk patients with DLBCL Mette Ø. Pedersen(1), Anne O. Gang (2), Tim S. Poulsen (1), Helle Knudsen (1), Anne F. Lauritzen (1), Signe L. Nielsen (1), Tobias W. Klausen (2), Michael Pedersen (2), Peter Brown (3), Peter Nørgaard (1), Shared first authorship (1)Department of Pathology, Herlev Hospital, Denmark, (2)Department of Haematology, Herlev Hospital, Denmark, (3)Department of Haematology, Rigshospitalet, Denmark. O3-4 Mutation frequencies of NOTCH1, SF3B1, MYD88, TP53 and POT1 in a cohort of CLL patients from the Region of Southern Denmark Louise Kristensen (1), Thomas Kielsgaard Kristensen (1), Cristina Royo (2), Niels Abildgaard (3), Elias Campo (2), Michael Boe Møller (1) (1)Department of Clinical Pathology, Odense University Hospital, (2)Anatomia Patólogica, Hospital Clinic, University of Barcelona, Spain, (3)Department of Haematology, Odense University Hospital. O3-5 Can EGFR-mutational status be reliably determined in pre-operative needle biopsies from adenocarcinomas of the lung? Kim Hein Lindahl(1,3), Flemming Brandt Sørensen(1,2), Søren Peder Jonstrup(1), Karen Ege Olsen(3) & Siegfried Loeschke(1,4) (1)Department of Pathology, Vejle Hospital, Denmark, (2)Institute of Regional Health Research, University of Southern Denmark, (3)Department of Clinical Pathology, Odense University Hospital, Denmark, (4)Department of Clinical Pathology, Southern Jutland, Soenderborg, Denmark O3-6 Invasive Lobular Carcinoma of the Breast - Incidence of Multifocal and Bilateral Tumours during a 2-year period in Aarhus Helene Lintrup Pedersen (1) Vibeke Jensen (1) (1)Department of Pathology, Aarhus University Hospital, Denmark. O3-7 Automated estimation of Ki67 in 100 breast carcinomas Nina Woller (1) Tim Svenstrup Poulsen (1) Eva Balslev (1) Michael Friis Lippert (2)

5 5 (1)Department of Pathology, Herlev Hospital, (2) Visiopharm, Hoersholm, Denmark. O3-8 ER, PR, HER2, and Ki67 Index and Responsiveness to Adjuvant Tamoxifen in Postmenopausal High-Risk Breast Cancer Patients enrolled in the DBCG 77C trial Ann S. Knoop(1,2), Anne-Vibeke Lænkholm(7), Maj-Britt Jensen(3), Kirsten V. Nielsen(4), Jørn Andersen(5), Dorte Nielsen(6), Bent Ejlertsen(2,3)for the Danish Breast Cancer Cooperative Group (1)Department of Oncology, Odense University Hospital, Odense, (2)Department of Oncology, Rigshospitalet, Copenhagen, (3)Danish Breast Cancer Cooperative Group, Copenhagen (4)Dako Denmark A/S, Glostrup, (5)Department of Oncology, Aarhus University Hospital, Aarhus, (6)Department of Oncology, Herlev University Hospital, Herlev, (7)Department of Pathology, Slagelse Hospital, Slagelse O3-9 GATA3 as a potential marker for breast carcinoma Dorte Kjaer(1), Anja Brügmann(2), Søren Nielsen(3), Vibeke Jensen(1). (1)Department of Pathology, Aarhus University Hospital, Aarhus, Denmark, (2)Department of Pathology, Viborg Hospital, Viborg, Denmark, (3)Department of Pathology, Aalborg University Hospital, Aalborg, Denmark O4-1 Efficient microrna inhibition in a highly invasive orthotropic glioblastoma model Bo Halle (1-3) Eric Marcusson (4), Charlotte Aaberg-Jessen (1-3), Stine Skov Jensen (1-3), Morten Meyer (5), Mette Katrine Schulz (2) Claus Andersen (2) and Bjarne Winther Kristensen (1-3) (1)Department of Pathology, Odense University Hospital, Winsloewparken 15, 5000 Odense C, Denmark, (2)Department of Neurosurgery, Odense University Hospital, Sdr. Boulevard 29, 5000 Odense C, Denmark, (3)Institute of Clinical Research, University of Southern Denmark, Winsloewparken 19, 5000 Odense C, Denmark, (4)Regulus Therapeutics, 3534 John Hopkins CT., Suite 210, San Diego, CA , USA, (5) Institute of Medical Biology, University of Southern Denmark, Winsloewparken 21, 5000 Odense C, Denmark O4-2 Pre-treatment diagnostic characteristics of 321 penile cancer patients - a national retrospective study from Denmark Jakobsen J.K.(1), Krarup K.P.(2), Sommer P.(2), Nerstrøm H.(2), Bakholdt V.(3), Sørensen J.A.(3), Olsen K.Ø.(4), Høyer S.(5),Toft B.G(6) Jensen J.B.(1) (01)Aarhus University Hospital, Dept. of Urology(1), Rigshospitalet, Copenhagen University Hospital, Dept. of Urology(2), Odense University Hospital, Dept. of Plastic Surgery(3), Odense University Hospital, Dept. of Urology(4), Aarhus University Hospital, Institute of Pathology(5), Rigshospitalet, Copenhagen University Hospital, Institute of Pathology(6) O4-3 Topoisomerase 1 and 2A gene copy number are elevated in colorectal cancer with proficient mismatch repair status Ida Marie Heeholm Sønderstrup(1), Sune Boris Nygård(2), Tim Svenstrup Poulsen(1), Dorte Linneman(1), Ib

6 6 Jarle Christensen(3), Nils Brünner(2), Peter Henrik Nørgaard(1), Lene Riis(1) (1)Department of Pathology, Herlev Hospital, (2)Section of Pathobiology, Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, (3)Finsen Laboratory, Rigshospitalet and Biotech Research and Innovati. O4-4 ERG protein expression at diagnosis is associated with increased risk of disease progression during active surveillance Kasper Drimer Berg(1), Ben Vainer(2), Frederik Birkebæk Thomsen(1), M. Andreas Røder (1), Thomas Alexander Gerds(3), Birgitte Grønkær Toft(2), Klaus Brasso(1), Peter Iversen(1) (1)Copenhagen Prostate Cancer Center, Department of Urology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, (2) Department of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark, (3)Department of Biostatistics, University of Copenhagen. O4-5 The Prostate cancer detection rate on the second prostate biopsy Zamel Hussain Zhaian (1), Karsten Nielsen (1) (1)Department of urology and Department of Pathology, Naestved Hospital, DK-4700 Naestved and Institute of Regional Health Research, University of Southern Denmark O4-6 Renal Cell Carcinoma the prognostic value of Fuhrman grades Sami Beji(1), Thomas Wagner Nielsen(2), Karsten Nielsen(2,3) (1) Department of Urology, Naestved Hospital, (2)Department of Pathology, Naestved Hospital, (3)Institute of Regional Health Research, University of Southern Denmark O4-7 Analysis of free circulating DNA in blood as a method for diagnosing and monitoring urinary bladder cancer patients Christina M. Dahmcke (1,2), Alastair B. Hansen (1), Per Guldberg (2) (1)Department of Pathology, Herlev Hospital, (2)CGL,The Danish Cancer Society O4-8 Evaluation of TOP1 gene copy number analysis in selecting prostate cancer patients for irinotecan treatment Jacob Bjerg Hansen(1), Sune Boris Nygård (2), Signe Lykke Nielsen(2), Nils Brünner(2), Anders Bjartell(3) and Ben Vainer (1). (1)Department of Pathology, Rigshospitalet, Copenhagen, (2)Section for Molecular Disease Biology, Department of Veterinary Disease Biology, Faculty of Health and Medical Sciences, University of Copenhagen, (3)Department of Clinical Sciences, Division of Urology, University of Lund, Sweden. O4-9

7 7 A comparison of the value of FNA and CNB in the clinical work up of cold thyroid nodules Vasilis Chatzikyriakos (1), Ida Maria Lisse (1), Katalin Kiss (1) (1) Department of Pathology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark P1-1 Case report: Small intestinal tophus mimicking tumour Katoch, Pragya (1), Trier-Mørch, Sara(2), Vyberg, Mogens(1) (1)Institute of Pathology, Aalborg University Hospital, Aalborg, Denmark, (2)Department of Abdominal Surgery, Aalborg University Hospital, Aalborg, Denmark P1-2 Medullary carcinoma versus poorly differentiated adenocarcinoma of the colon can the undifferentiated be differentiated? Anne-Marie Kanstrup Fiehn (1), Ben Vainer (1), Anders Glenthøj (1), Gro Linno Willemoe(1). (1)Department of Pathology, Rigshospitalet, Copenhagen, Denmark. P1-3 Inflammatory fibroid polyp (IFP) with aberrant features Dorte Gybel-Brask (1), Tina Agander(1), Ulla Engel1, Susanne Holck (1) (1)Department of Pathology, Copenhagen University Hospital, Hvidovre P1-4 Cellulitis-like cutaneous metastasis as the first clinical sign of signet ring cell gastric carcinoma Annedorte Ries (1), Preben Løvgreen Nielsen (1) (1)Department of Pathology, Roskilde Hospital. P1-5 Undifferentiated carcinoma of the pancreas with osteoclast-like giant cells: A case report Rouzbeh Salmani (1), Jane Preuss Hasselby (1), Birgitte H. Federspiel (1) (1)Department of Pathology, Copenhagen University Hospital, Rigshospitalet. P1-6 The challenges of molecular cancer mutation analysis: NRAS testing in colo-rectal cancer specimens Reza Rafiolsadat Serizawa(1), Delfina Fornari(1) Ulla Engel(1), Susanne Holck(1), Helle Pedersen(1), Jesper Bonde(1,2). (1)Department of Pathology, Copenhagen University Hospital Hvidovre, Denmark (2)Clinical Research Centre, Copenhagen UnO3iversity Hospital Hvidovre, Denmark. P1-7 IQGAP1 in rectal carcinomas before and after radiochemotherapy Susanne Holck (1), Emilie Hammer (2), Hans Jørgen Nielsen (2) and Lars-Inge Larsson (1) (1)Department of Pathology, Hvidovre Hospital, (2)Department of Surgery, Hvidovre Hospital.

8 8 P2-1 Autoimmune pancreatitis in Denmark: A single-centre study of 30 patients with histological, serological, imaging and clinical follow-up data Sönke Detlefsen(1), Michael Bau Mortensen(2), Anne-Sofie Cribe(3), Torsten Pless(2) and Ove B. Schaffalitzky de Muckadell(3). (1)Dept. of Pathology, Odense University Hospital, Odense, Denmark, (2)Dept. of Surgery, Odense University Hospital, Odense, Denmark, (3)Dept. of Medical Gastroenterology, Odense University Hospital, Odense, Denmark. P2-2 Extramammary Paget s disease in a mature cystic teratoma of the ovary May Murra (1), Aliaksandr Obukhau (1), Trine Tramm (1). (1) Department of Pathology, Randers Hospital, Denmark P2-3 Lipomatous tumours of the uterus: A report of 3 cases Thomas Wagner Nielsen (1), Karsten Nielsen (1+2) (1)Department of Pathology, Naestved Hospital, (2)Institute of Regional Health Research, Odense P2-4 Massive ovarian oedema in a 7-year old girl: a case report Gitte Hedegaard Jensen(1) Iben Birgit Gade Johnsen(1) (1)Department of Clinical Pathology, Odense University Hospital, Odense, Denmark P2-5 Adequacy in cervical cytology when changing from smear technique to liquid based technique Susanne Merete Nielsen (1), Karsten Nielsen (1, 2) (1)Department of Pathology, Naestved Hospital, (2)Institute of Regional Health Research, University of Southern Denmark. P2-6 Prostate specific antigen (PSA): Age specific reference intervals and PSA and the 5 years risk of prostate cancer. Results from a population based register study Sarah Hjartbro Bube (1), Ida Behrens (1), Lise Barthum (2,3), Karsten Nielsen (3,4) (1)Department of Urology, Naestved Hospital, (2) Department of Clinical Biochemistry, Naestved Hospital, (3)Institute of Regional Health Research, University of Southern Denmark, SDU, (4)Department of Clinical Pathology, Naestved Hospital P2-7 Renal Epithelioid Angiomyolipoma with atypia: A case report and review of the literature Marie Bjødstrup Jensen(1) Morten Andersen(2) Ulla Møldrup(2) Søren Høyer(1) (1)Department of Pathology, Aarhus University Hospital, Aarhus (2)Department of Urology, Aarhus

9 9 University Hospital, Aarhus P2-8 How to decalcify prostatectomy specimens without losing amplifiable DNA Lykke Grubach(1), Louise Serup Christoffersen(1), and Astrid Petersen (1). (1)Department of Pathology, Aalborg University Hospital. P3-1 Findings in passing stools Susanne Eiholm (1) (1)Department of Pathology, Roskilde Hospital P3-2 Why autopsies? - A ruptured abdominal aortic aneurism mimicking intra cranial haemorrhage Lenler-Eriksen, S. (1), Hager H. (1) (1)Institute of Pathology, Aarhus University Hospital, Aarhus, Denmark. P3-3 Carcinosarcoma of the breast: a diagnostic challenge LL Jensen (1), P Vahl, V Jensen (1) (1)Department of Pathology, Aarhus University Hospital, Denmark. P3-4 Could sentinel lymph node biopsy be omitted in tubular carcinoma of the breast?-a retrospective single centre study Torshamar UEÓ, Di Caterino T (1)Department of Pathology, Hospital of South Western Jutland, Esbjerg, Denmark P3-5 A multi-disciplinary effort towards the diagnosis of Pompe disease in a young adult. An example of the muscle biopsy as an important diagnostic tool Anne R Ellingsen(1), Julie S Hansen(2), Caroline M Andreasen(3), Anne Grosen(4), Henning Andersen(2). (1)Institute of Pathology (2), Dept. of Neurology, (3) Dept. of Rheumatology and (4)Dept. of Hepatology and Gastroenterology, Aarhus University Hospital. Denmark. P3-6 Malignant lymphoma in Warthin s tumour; one tumour, two entities? Marie Fredslund Breinholt (1) (1)Department of Pathology, Roskilde Hospital. P3-7 BRAF analysis - a diagnostic tool for tall cell variant of papillary thyroid carcinoma Mette Bak Nielsen (1), Marie Louise Jespersen (1)

10 10 (1)Department of Pathology, Aarhus University Hospital P4-1 Clinical and analytical evaluation of the BD Onclarity HPV assay in women referred for colposcopy Ditte Møller Ejegod(1), Jette Junge(1), Benny Kirschner(2), Maria Franzmann(1), Carsten Rygaard(1), Maria Teresa Sandri(4), Mario Sideri(4) & Jesper Bonde(1,3). (1)Department of Pathology, (2)Department of Gynaecology, (3)Clinical Research Center, Copenhagen University Hospital, Denmark, (4) Laboratory Medicine Division, European Institute of Oncology, Milan, Italy. P4-2 HC2 versus Cobas HPV test in SurePath samples from women aged 30 years with ASCUS Fornari D(1,2), Bjerregaard B (1), Lidang M (1), Bonde J (2,3), Christensen IJ (4), Høgdall E (1) (1)Herlev University Hospital, Department of Pathology, Herlev, Denmark, (2)Hvidovre University Hospital, Department of Pathology, Hvidovre, Denmark, (3)Hvidovre University Hospital, Clinical Research Center, Hvidovre, Denmark, (4)Finsen Laboratory, Rigshospitalet, Denmark P4-3 Comparison of Genomica CLART HPV2 genotyping assay to Roche Linear Array HPV genotyping assay and Qiagen Hybrid Capture 2 Helle Pedersen(1), Ditte Møller Ejegod(1), Matejka Rebolj(3), Jette Junge(1), Maria Franzmann(1), Carsten Rygaard(1) and Jesper Bonde(1,2). (1)Department of Pathology, Copenhagen University Hospital, Hvidovre, Kettegaard Allé 30, 2650 Hvidovre, Denmark. (2)Clinical Research Center, Copenhagen University Hospital, Hvidovre, Kettegaard Allé 30, 2650 Hvidovre, Denmark. (3) University of Copenhagen, Department of Public Health, Copenhagen, Denmark. P4-4 Clinical and Analytical evaluation of the BD Onclarity HPV Assay on BD SurePath samples from women with abnormal cytology Ditte Møller Ejegod(1), Jette Junge(1), Maria Franzmann (1), Carsten Rygaard(1), Maria-Teresa Sandri(3), Mario Sideri(3) & Jesper Bonde(1,2). (1) Department of Pathology, (2) Clinical Research Center, Copenhagen University Hospital, Denmark, (3) Laboratory Medicine Division, European Institute of Oncology, Milan, Italy. P4-5 Inter and intra laboratory reproducibility of BD Onclarity HPV assay in ThinPrep primarily screening samples Ditte Møller Ejegod(1), Itziar Serrano(3), Kate S. Cuschieri(4), William A. Nussbaumer(5), Laurence M. Vaughan(5), Amar S. Ahmad(6), Jack Cuzick(6) & Jesper Bonde(1,2) (1) Department of Pathology, Copenhagen University Hospital, Hvidovre, Denmark. (2) Clinical Research Centre, Copenhagen University Hospital, Hvidovre, Denmark. (3) HPV Research Group, Queens Medical Research Institute, Edinburgh UK. (4) Specialist Virology centre, Royal Infirmary of Edinburgh, UK. (5) BD Diagnostics, 54 Loveton Circle, Sparks, MD 21152, USA. (6) Centre for Cancer Prevention, Wolfson Institute

11 11 of Preventive Medicine, Charterhouse Square, London, UK. P4-6 HPV prevalence and genotype distribution in a population-based split-sample study of well-screened women using CLART HPV2 Human Papillomavirus genotype microarray system Preisler S (1,2), Rebolj M (3,1,2), Ejegod D (1), Lynge E(3), Rygaard C (1), Bonde J (1,2) (1)Department of Pathology, Copenhagen University Hospital, Hvidovre, (2)Clinical Research Centre, Copenhagen University Hospital, Hvidovre, (3) Department of Public Health, University of Copenhagen P4-7 The reproducibility of the Cobas HPV Assay evaluated in a screening population of woman aged years Dorthe Ørnskov (1) Marianne Waldstrøm (1,2) (1)Department of Pathology, Vejle Hospital, Denmark (2) Institute of Regional Health Research, University of Southern Denmark. P4-8 SurePath cytology medium for HPV testing using cobas HPV test, APTIMA HPV test, HC2, BD Onclarity HPV test and CLART HPV2 genotyping assay. A joint report form the Danish HORIZON study and the Danish BD Onclarity Trial Ditte Møller Ejegod(1), Matejka Rebolj(3), Sarah Preisler(1,2), Elsebeth Lynge(3), Carsten Rygaard(1), Jesper Bonde(1,2). (1)Department of Pathology, Copenhagen University Hospital, Hvidovre, Kettegaard Allé 30, 2650 Hvidovre, Denmark. (2)Clinical Research Center, Copenhagen University Hospital, Hvidovre, Kettegaard Allé 30, 2650 Hvidovre, Denmark. (3) University of Copenhagen, Department of Public Health, Copenhagen, Denmark P5-1 Molecular HPV diagnostics and benign dermatopathology Marie Boennelycke (1), Ulla Hansen (1), Susanne Holck (1), Jesper Bonde (1,2) (1)Department of Pathology, Copenhagen University Hospital Hvidovre, Denmark, (2)Clinical Research Centre, Copenhagen University Hospital Hvidovre, Denmark P5-2 Filaggrin expression in normal tissues Kallenbach K(1), Høgdall E(1), Stender S(2), Thyssen JP(3), Johansen JD(3), Menné T(3), Carlsen BC(3), Balslev E(1), Szecsi P(2) (1)Department of Pathology, Herlev Hospital, (2)Department of Clinical Chemistry, Gentofte Hospital, (3)Department of Dermatology, Gentofte Hospital. P5-3 Merkel Cell Carcinoma concurrent with Bowen s disease and superficial basal cell carcinoma: A case report

12 12 Kiran Sheikh (1), Thomas Hasselager (1) (1)Department of Pathology, Herlev Hospital, Denmark. P5-4 Is immunohistochemistry useful in the distinction of basaloid PCC versus BCC in the anal region? Kiran Sheikh (1), Lene Buhl Riis (1) (1) Department of Pathology, Herlev Hospital P5-5 Lymphomatoid papulosis type D or an aggressive epidermotropic CD8-positive cytotoxic T-cell lymphoma the importance of clinicopathologic correlation Mathilde Skaarup Larsen(1), Rosa Marie Andersen(2), Tim Svenstrup Poulsen(1), Lone Skov(2), Anne Falensteen Lauritzen(1). (1)Department of Pathology, Copenhagen University Hospital Herlev, (2)Department of Dermato- Allergology Copenhagen University Hospital Gentofte. P5-6 Necrotic ulcer on the lower lip caused by infection with orthopoxvirus Mette Bybjerg Jensen (1) Lone Skov (2) Søren Kamp (2) Charlotte Winther (1) Signe Ledou Nielsen (1) (1)Department of Pathology, Herlev Hospital, (2)Department of Dermatology, Gentofte Hospital. P5-7 Langerhans cell histiocytosis presented as skin lesions in an adult: a case report Katrine Togsverd-Bo(1), Ann Sophie Lønnberg (2), Lone Skov (2), and Signe Ledou Nielsen (1). (1)Department of Pathology, Herlev Hospital, (2)Department of Dermatology, Gentofte Hospital P5-8 Malignant melanoma within an intradermal nevus a case report Pia Wirenfeldt Staun (1) (1)Department of Pathology, Hospital of South Western Jutland, Esbjerg, Denmark. P6-1 JAM-A - a novel prognostic marker in glioblastoma Ann Mari Rosager1,2, Rikke H. Dahlrot1-3, Steinbjørn Hansen2,3, Justin D, Lathia4, Bjarne W. Kristensen1,2 (1)Department of Pathology, Odense University Hospital, Odense, Denmark, (2)Institute of Clinical Research, University of Southern Denmark, Odense, Denmark, (3)Department of Oncology, Odense University Hospital, Odense, Denmark, (4)Department of Cellular and Molecular Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, OH 44195, USA P6-2 c-met is a new prognostic biomarker in glioblastoma patients Stine A. Petterson(1,2), Simon K. Hermansen(1,2), Rikke H. Dahlrot(1-3), Steinbjørn Hansen(2-3), Bjarne W.

13 13 Kristensen(1,2) (1)Department of Pathology, Odense University Hospital, Odense, Denmark, (2)Institute of Clinical Research, University of Southern Denmark, Odense, Denmark, (3)Department of Oncology, Odense University Hospital, Odense, Denmark P6-3 High levels of TIMP-1 can reduce the effect of topoisomerase inhibitors on glioblastoma cells Charlotte Aaberg-Jessen (1), Louise Fogh (2), Bo Halle (1, 3), Vibeke Jensen(2), Nils Brünner (2) and Bjarne Winther Kristensen (1). (1)Department of Pathology, Odense University Hospital, Institute of Clinical Research, University of Southern Denmark, Denmark. (2)Section of Molecular Disease Biology, Department of Veterinary Disease Biology, (3)Faculty of Health and Medical Sciences, Copenhagen. P6-4 Multi-disciplinary meetings within uro-oncology in Region Midt/Nord Jakob Kristian Jakobsen(1), Jørgen Bjerggaard Jensen(1), Søren Høyer(2) on behalf of the multidisciplinary uro-oncological group in Region Midt/Nord (1)Aarhus University Hospital, Dept. of Urology, (2)Aarhus University Hospital, Institute of Pathology. P6-5 DNA derived from PAXgene Tissue System fixed material is suitable for genome wide DNA methylation study Gitte Brinch Andersen (1), Henrik Hager (3), Lise Lotte Hansen (1), Jorg Tost (2) (1)Department of Biomedicine, Aarhus University, (3)The Bartholin Building, Wilhelm Meyers Allé 4, DK Aarhus C, Denmark, (2)Centre National de Génotypage, CEA - Institut de Génomique, Batiment G2, 2 rue Gaston Crémieux, CP5721, Evry Cedex, France P6-6 Quantification of regulatory T-cells in bone marrow biopsies from patients with Philadelphia Chromosome Negative Chronic myeloproliferative neoplasms using immunohistochemical methods Marie Fredslund Breinholt(1), Michael Bzorek(2),Signe Ledou Nielsen(1) (1)Department of Pathology, Herlev Hospital, (2) Department of Pathology, Naestved Hospital. P6-7 EBV positive diffuse large B-cell lymphoma of the elderly and preceding Angioimmunoblastic T-cell lymphoma Gitte Wooler(1), Peter Nørgaard(1)and Signe Ledou Nielsen(1). (1)Department of Pathology, Herlev Hospital, Denmark. P6-8 c-myc Expression In Newly Diagnosed Multiple Myeloma Agoston Gyula Szabo (1), Anne Ortved Gang (2), Mette Ølgod Pedersen (1), Tim Svenstrup Poulsen (1),

14 Tobias Wirenfeldt Klausen (2), and Peter H. Nørgaard (1) (1)Department of Pathology, Copenhagen University Hospital Herlev, Herlev, Denmark, (2)Department of Haematology, Copenhagen University Hospital Herlev, Herlev, Denmark. 14