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1 Meeting Time and Date: Meeting Venue: Attendance Location: June 2014 Second University of Naples, Naples IT To register send to: Registration does not cover subsistence or travel costs. Invited speakers only will be reimbursed via the COST office. Croce di Lucca auditorium, Second University of Naples, piazza Miraglia, Naples IT

2 COST action SeqAHEAD: Next Generation Sequencing Data Analysis Workshop: Translating emerging seq- based technologies into integrated biomedical approaches June 2014, Naples, Italy Seconda Università degli Studi di Napoli, Dipartimento di Biochimica, Biofisica e Patologia generale Sant Andrea delle Dame via Costantinopoli 8 and vico L. de Crecchio 7, Naples. Preliminary Program 23 June Welcome and Introduction Chair: Prof. Altucci Lucia, Dr. Mariarosaria Conte Get to know each- other! 10, Prof. Carlo Altucci, Federico II University, Naples, IT Laser- ChIP: review, prospects, microscopic model systems" Question time Prof. Lucia Altucci, Second University of Naples, ITLChIP biological applications Laser- ChIP: biomedical applications Question time Prof. Hendrik G. Stunnenberg, Radboud University. Nijmegen, NL Multi- dimensial Omics approaches in personalized medicine Question time Lunch Typical Neapolitan lunch will be offered to the invited speakers at Hotel Piazza Bellini Short Talks.

3 Dr Angela Nebbioso, Second University of Naples, IT L- ChIP experimental procedures and analysis Dr Rosaria Benedetti, Second University of Naples, IT Biological effects of irradiation and experimental analysis of damages Prof. Gianluca Sbardella, University of Salerno. Salerno, IT ' Chemical instruments to play in the epigenetic orchestra: sound, silence, and the notes in between Prof. Roberto Improta, CNR, Naples, IT 'Photoproducts in DNA following UV absorption: insights from Quantum Mechanical calculations' Question time Prof. Raffaele Velotta, Federico II University, Naples, IT "Photonic Immobilization Technique for Quartz Crystal Microbalance immuno- sensors" Question time 20,00 Invited Speaker dinner and drinks at: Hotel Piazza Bellini, Piazza Bellini, Napoli, IT.

4 2014 June Welcome and Introduction Chair: Prof. Raffaele Velotta, Prof. Altucci Lucia, Dr Vincenzo Carafa Prof. Ivo Gut, Centre Nacional d'anàlisi Genòmica (CNAG), Barcelona, ES To be defined Question time Prof. Vincenzo Barone, Scuola Normale Superiore, Pisa, IT SMART: Space- time Multiscale Approaches for Research and Technology Question time Dr. Christoph Merten, EMBL Heidelberg, DE Single- cell Screening and Beyond: Miniaturizing Biology in Microfluidic Systems Question time Dr. Haico van Attikum, Leids Universitair Medisch Centrum (LUMC), NL Orchestration of the DNA damage response in chromatin Question time Lunch & Coffee at Hotel Piazza Bellini Dr. Michiel Vermeulen, University Medical Centre Utrecht, NL Quantitative interaction proteomics for epigenetics' Question time Dr. Erik Bongcam- Rudloff, SLU- Global Bioinformatics Centre, Uppsala "Next- Generation Sequencing (NGS): future perspectives" Question time Dr. Christoph Bock, CeMM Research Center, Vienna Analyzing and interpreting large- scale DNA methylation data Question time Dr. Claudia Angelini, Istituto per le Applicazioni del Calcolo "Mauro Picone" - Consiglio Nazionale delle Ricerche Developing computational tools for NGS data analysis in the spirit of reproducible research Question time Concluding Remarks, ROUND TABLE for collaborations.

5 Additional Attendees 1. Angela Avitabile 2. Vincenzo Carafa 3. Alfonso Ciotta 4. Mariarosaria Conte 5. Lidio Conte 6. Carmela Dell Aversana 7. Nunzio Del Gaudio 8. Floriana Della Ragione 9. Bartolomeo Della Ventura 10. Antonella Di Costanzo 11. Carlo Fasano 12. Gianluigi Franci 13. Monica Franzese 14. Riccardo Funari 15. Miriam Gagliardi 16. Cristina Giorgio 17. Rahil Golipour 18. Mario Guarracino 19. Mohammad Hassan Valadan 20. Concetta Iside 21. Maria R Matarazzo 22. Marco Miceli 23. Gabriella Minchiotti 24. Francesca Petraglia 25. Lorenzo Ricupito 26. Natalia Russo 27. Angela Salvato 28. Lucia Scisciola 29. Maria Strazzullo 30. Alessandra Tosco 31. Marcella Vacca 32. Francesco Russo 33. Antonio Christian Pagano Zottola

6 How to reach us: LOCATION: The meeting venue is the prestigious Church Croce di Lucca, property of the Second University of Naples, fully equipped to hold meetings of international relevance Church Croce di Lucca * Croce di Lucca. The unusual name refers to the Cross of Lucca, a particular crucifix in the Cathedral of Lucca, the town in Tuscany. The Carmelites in Naples venerated that object and dedicated the church and monastery to it. It has nothing to do with Luke the Evangelist ('Luca' in Italian).

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8 From the central station: By public transport: from Piazza Garibaldi use the local line Anm 47 or use the subway line 2 to exit at Piazza Garibaldi and Piazza Cavour. Walk towards the National Museum, turn left on Via S. Maria of Constantinople and then left again to go up the alley Luigi de Crecchio. Alternatively use new Line 1 metro station Garibaldi, to reach Museum. From Naples Airport (Capodichino): By public transport: use of the lines alibus until arrival at Piazza Garibaldi. See the underground map of Naples. What to see in Naples, Italy

9 Naples heart - the historic centre of Napoli Naples heart is the historic city, which UNESCO declared a Cultural Heritage site. Its narrow alleyways lead to mysterious churches, catacombs and underground caves. Until today, Naples old folk culture reveals itself to the visitor among craftspeople, fluttering laundry and shouting fish sellers.the historic city is characterized by many churches. You often find several of them in one street among Baroque style palaces of aristocratic families and antique residences. Naples most important church is the San Gennaro (St. Januarius) Cathedral, where each year the famous Miracle Blood ceremony takes place. The Gothic churches, San Lorenzo Maggiore and San Domenico Maggiore, as well as the Baroque church, Gesù Nuovo, are worth a visit. The San Severo Chapel is fascinating because of its mysterious anatomic machines, two skeletons that are inexplicably covered with a system of fossil veins and arteries. In addition, you can see beautiful Baroque sculptures from the 17th and 18th century. A wonderful place to take a rest is the garden of the Santa Chiara Convent with its columns, little benches, and walls that are wainscoted with beautiful colorful majolica. Vis- à- vis on Via San Sebastiano, you can find music stores that, because of their vicinity to the conservatory, still sell mandolins. Nearby is the street of the booksellers, Port Alba, where you can buy delicious pizza at the street counter of the pizzeria of the same name and eat it right away.a trip to Naples s underworld is an exciting experience: Under the city, which stands on tufa, is a labyrinth of caves some 80 km long. The gate to the underworld is tucked away at the Piazza San Gaetano. The guided tours take 1.5 hours. The historic city offers numerous places to do some shopping, above all, for crafts, antiques, and souvenirs. You should definitely visit the Via San Gregorio Armeno, the famous street of the nativity scene makers (neapolitan cribs, in italian presepe napoletano). During Christmas time, more than half a million tourists come to see the shops with the original miniature figurines. However, they are open all year round and you can take your time and have a look around after New Year s. Piazza del Gesù Port Alba- Piazza Dante Piazza Bellini Crib(presepe)

10 How to reach the historic centre of Napoli: The best way to see Naples heart is on foot!by underground (subway) Metro Line 1 - Piazza Dante station or by Bus (Piazza Dante bus stop), then walk direction Port'Alba/Piazza Bellini. Lungomare: A Walk Along the Seashore Via Partenope is the beginning of the seafront road where Castel dell Ovo (Egg s Castle) rises on an island that is connected to the mainland. From the castle, you have a fantastic view of the Mount Vesuvius as well as the quarters Mergellina and Posillipo. At the picturesque marina you find excellent restaurants and bars.a little further, Villa Comunale, a big park with palm trees, chalets, and beautiful fountains, extends along the famous seafront road, Via Caracciolo. If you are interested, you can visit the zoological station, Aquarium Dohrn, which is Europe s oldest aquarium. The walk along the seashore to the touristic harbour of Mergellina is very romantic. Close by the harbour, fishermen sell their freshly caught fish. At the end of Via Caracciolo, nice chalets invite you to have a cocktail while you are enjoying the sea view. Via Partenope The Seashore How to reach the Seashore: By underground (subway) Metro Line 2 - Piazza Amedeo station or by Bus Line R3, Riviera di Chiaia bus stop For more information, please visit:

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