we care about the brain

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1 we care about the brain Annual Report 2010

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5 Table of contents 1. Table of Contents Preface Description Research Institute Structure Research Institute SWOT Analysis News & Highlights International Collaboration Input Research Institute...19 a) Funding b) Fte per type of funding c) Number of newly started PhD projects Output Research Institute...23 a) Scientific Output b) Scientific Quality c) Indicators of Esteem d) Societal Impact 10. Per Research Program...29 a) Description b) Input (per program) c) Output (per program) 11. Scientific Research Committees Education & Training...58 Appendices

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7 2. Preface Here we present our third annual report. We have grown since 2008 both in numbers of coworkers being involved, in the total number of publications and in particularly also with regard to the high impact of our collaboration. We were able to continue our grant successes, including more acquisition in FP7, participation in a new FES consortium ( and being awarded with a so-called Erasmus Mundus Master Course stipend-program, under guidance of our European Neuroscience Campus Network ( which was previously awarded with a Erasmus Mundus Joint Doctorate program. By combining the latter two acquisitions in the ENC- Network, under our coordination, we have now formalized the European dimensions of our graduate training. The aggregate of conditional funding for the Neuroscience Campus Amsterdam in 2010 amounted to ~ 30 M, which is a major increase since 2008 and The number of shared and high impact publications has stabilized since We have a collective strategy, resulting in a major wave of over 80 collaborative projects. In 2010, this resulted in more than 450 peer reviewed research reports, of which > 60 papers had an impact factor of >10, including several Nature Genetics papers, many papers in the Lancet (Neurology), in addition to a few papers in Science, in Brain and in PNAS. With Queen Beatrix, we celebrated the 10 year jubilee - and opening of the new housing facilities - of the VUmc Alzheimer Center under guidance of Prof. Philip Scheltens. We have made new investments in infrastructural facilities for stem cell research, for cellomics, and for photonics and life cell imaging. In addition, our biobanking, genomics and electron microscopy facilities have been modified and updated. We have also witnessed the contributions of a senior role model, Prof. Dennis Selkoe from Harvard University and recipient of the 2010 Honorary Doctorate from the VU University Amsterdam in collaboration with the VU Medical Center. Dennis Selkoe - who has devoted his lifetime career to the use of molecular approaches to study neurodegenerative diseases - inspired us to start thinking about a valorization strategy, as extensively discussed during last year s Valorization Symposium on 19 October in the ING house. In short, all aspects of running a translational research institute are presented, and it is on behalf of all students and coworkers that we deliver this annual report. Arjen Brussaard director 5

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9 3. Description Research Institute Neuroscience Campus Amsterdam Neuroscience research is a high profile knowledge industry and aims at making seminal contributions to the understanding of the human brain and the fight against brain disease. Our current insight coming from recent studies of Neuroscience Campus investigations into the human genome and networks of genes, interacting proteins, neuron-glia interactions, and synaptic transmission embedded in neuronal networks has paved the way towards the understanding the molecular and cellular basis of higher brain functions and its pathology. In parallel, on our campus, numerous brain imaging, neurological studies and psychiatric research of large cohorts of patients have created valuable assets that are unique worldwide. We have transcended the boundaries of various disciplines including biomedical, biophysical, biopsychological and clinical neurosciences. The ongoing research strategy, and output of the collaborative research programs of the Neuroscience Campus Amsterdam, thereby focusing on the most important and pioneering areas of neuroscience, have been described in the annual report. The Neuroscience Campus Amsterdam houses more than 450 professionals on one campus and they all collaborate in the field of Translational Neurosciences to an extent that is unique in the Netherlands. The partners in this network organization are the investigators and graduate students, gathered in interdisciplinary research teams and executing our research programs. All our research activities are essentially interdisciplinary and incorporate the newest theoretical, methodological and application paradigms currently available. Our strongholds and international reputation builds both on previous work in molecular biology and biology and genetics of the brain, synapse function and neuronal networks, as well as on our clinical studies of the major brain diseases. We study the brain and its disease mechanisms through an integrative approach from molecule-to-bedside and back. We apply a systems biology approach of the brain where clinicians and clinical researchers are working side-by-side with neuroscientists, geneticists, psychologists, biophysicists and statisticians. Through this collaboration we aim at delivering proof-of-concept for radically new approaches in the early diagnosis of brain disease, the elucidation of its underlying mechanisms, and thus providing new perspectives on therapy. 7

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11 4. Structure Research Institute Mission The mission of the Neuroscience Campus Amsterdam is to study the brain and its disease mechanisms through an integrative approach running from molecule-tobedside. We apply a systems biology approach of the brain where clinicians and clinical researchers are working side-by-side with neuroscientists, geneticists, psychologists, biophysicists and statisticians. Aims & Objectives The Neuroscience Campus Amsterdam currently the largest neuroscience research community gathered on one campus in the Netherlands. We are strongly focusing on molecular neurobiology, going all the way from biophysics, genetics, genomics and systems biology of the synapse, to heritability and genetic basis of brain function. Research Activities The Neuroscience Campus Amsterdam teams focus on three areas of research supported by Support Facilities: Advanced technology Programs, Genes & the Brain and Brain Disease Mechanisms. Advanced Technology Programs Brain Disease Mechanisms Research Support Facilities Genes & the Brain Figure 1. Main stream research areas of the Neuroscience Campus Amsterdam 9

12 Figure 2. Research Programs. As shown in Figure 2, each research activity area is further subdivided in a focused number of research programs and facilities. These have been further described in section 10 of this annual report. 10

13 Advanced Technology Programs The Neuroscience Campus Amsterdam puts much effort in Advanced Technology Programs, thereby securing a strong translational link between those groups providing for instance tailor-made Photonics technology and laboratories where these methods can be successfully applied (i.e. human health and life sciences). In additional there is an established translational link between the Brain Imaging experts and those involved in any of our Brain Disease Programs, including our so-called imaging genetics initiatives. Statistical geneticists, biostatisticians and bioinformatics experts provide state-of-the-art Integrated Analysis and Modeling methodology; (neuro)psychologists and clinicians apply this methodology when screening patients, their genes and their endophenotypes. Further novel insight is being generated through reconstruction of synaptic gene networks in the Systems Biology of the Synapse program. Finally, there is potentially a strong link between the Drugs screening and Therapy Design program and clinical activities of the Brain Disease Mechanisms teams Genes and the Brain The words molecules, genes, synapses, connectivity and brain function are the buzzwords of all our initiatives. This interest provides a strong translational potential between genetics, molecular neurobiology, functional genomics, neurophysiology, psycho-pharmacology and behavioral neuroscience within the area 'genes and the brain' but also between the latter and the 'brain disease mechanism' programs. There is strong collaboration between labs providing research support and investigators that largely depend on such activities including the clinicians and the statistical geneticists. Brain Disease Mechanisms All research in the Brain Disease Mechanisms programs is aimed and integrated with our in-house patient clinics, notably the VUmc Alzheimer Center, the Multiple Sclerosis Center Amsterdam and the treatment of Depression in the GGZBA-clinic. In addition, given the fact that we have a growing number of Parkinson's disease patients, the research program also includes research on patient-material from these patients. Moreover, also nicotine- and alcohol-abuse data of our depressed patients is being analyzed in the Addictive Behavior Program. The link between attentive traits in human twins and those being observed in ADHD patients continues to provide a further strong translational program towards the understanding of attentive behavior, impulsivity and cognition in general. Support Facilities Support Facilities are aimed at one-way research support, thereby serving as core facilities to generate data and provide tissue- or sample-analysis, or generate models (including transgenic mice and cell lines) in relation to specific research-project questions. The research project questions are generated, prioritized and argued (in relation to the overall research program) by the program committee c.q. the program leaders. 11

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15 5. SWOT Analysis Rationale In order to be able to continue to invest in scientific excellence and the translational potential of our disease-oriented brain research and graduate training, the Neuroscience Campus Amsterdam needs to generate new funding. This SWOT analysis outlines arguments and reasons why now is the right time to orient part of our research activities towards collaboration with the industrial market. The aim of such shift towards a market oriented position would be to capitalize on our scientific expertise and academic excellence and create an open innovation climate on campus both for technology-push and market-pull and to stimulate the market-potential of our young graduates and upcoming professionals. Strength Since the start of this campus-wide collaboration we have been forming new expertise-teams and have invested in more than 80 new translational projects. In addition to the 120 PhD projects currently running on campus, the European Neuroscience Campus Network (ENC-Network) was set up, to formalize the international setting of our graduate training program, both of the Master of Neurosciences and of the Joint PhD in Neurosciences. This has brought the Neuroscience Campus Amsterdam in connection with a selection of major and opinion leading institutes in Europe. The acquisition of National Research Council and European funding is currently funding around 75% of our ongoing concern (current acquisition ~ 25 M /year). New infrastructures including an automated cellomics facility, photonics setups and a stem cell laboratory was installed. Major prizes and research grants were awarded including an ERC Advanced Grants, an Erasmus Mundus Joint Doctorate grant, a Marie Curie ITN network grant and coordinatorship of at least two large collaborative FP7 grants. When it comes to brain disease, the Neuroscience Campus Amsterdam is focused on Alzheimer's disease, Multiple Sclerosis and chronic depression. Within these research programs, our MDs bring clinical issues to the lab, and vice versa PhDs participate in identifying new biomarkers, diagnostic as well as putative targets and tools for therapy. In doing so, we aim both at technology push and at market pull valorization, using our advanced technology research programs, our in-depth knowledge of the genetics of the brain, and having access to large patient cohorts, bio-banking capacity, transgenic mouse models and state of the art genomics, proteomics, brain imaging as well as brain modeling expertise groups. Weaknesses To make the efforts of the collaborations within the Neuroscience Campus endurable initiatives we need to design alternative strategies that would give rise to new funding for innovation initiatives on campus. Thus in addition to dedicating tenured, and collaborating on conditional national and European funding, we need to invest in endurable collaborations with industry. 13

16 One way of generating more research funding would be to invest in profitable Contract Research (CR) and participate more in Clinical Trials (CTs) than is currently done. Also funding coming from consultancy services to biotechnology and pharmaceutical industry could be increased and professionalized. Also, our bio-banking efforts are thus far not used as an asset in any for-profit business model. Finally, Clinical Trials are performed with external CROs (Contract Research Organizations) and Contract Research is not sufficiently organized by - or stimulated with - the help of the faculties and the medical school. Opportunities The industrial market and putative sponsors are often oriented towards thematically organized knowledge-domains and innovation - and not towards mono-disciplinary R&D. The Neuroscience Campus Amsterdam is an ideal party to collaborate with industry since it has organized its R&D by building on the trans-disciplinary strengths of our collaborations. The international reputation of our publications is strong, and of high impact. The expertise and infrastructure is excellent. However, as indicated above, we fail to benefit from this in an economic perspective. Therefore now is the right time to start creating industrialacademic partnership on campus, and start building on collaborations that are characterized by open innovation and where creating new funding for the academic sector is an integral part of the business model. Our unique selling point is that clinical trials performed on campus can be directly coupled to laboratory based contract research aimed at generating mechanistic insights. Finally, we can combine the clinical and preclinical CRO activities with a solid support of applying for European FP7 funding aimed by IAPP and other grants. Threats In order to be able to implement this novel valorization strategy aimed at servicing and collaborating with industrial partners, a new business model needs to developed, aimed at setting up a dedicated CRO office for the Neuroscience Campus Amsterdam. In this market-oriented front office, scouting of new collaborations, advertisement of our research capacity to participate in product development, and consultancy and professional expertise will be organized. The modus operandi of the CRO office is to support both technology push (being an integral function of TTO) and organize market pull. The CRO office would function as an 'outlet' of our translation potential, our patient cohorts, the expanding research capacity and our human resources. Moreover in doing so we would open the road for young professionals to participate in spin-off as well in spin-in research collaborations. Not making choices and not taking consequences of choices both may seriously hamper the forward transition of our institute-strategy. Not making choices with respect to deciding which research-groups in fact can bring our campus in the best position to continue our achievements with respect to scientific excellence but to also combine this with modern and common sense valorization strategy. And not taking the consequences of such choices, regardless of whether it concerns the organizational and administrative setting of interfaculty research institutes, its housing conditions or budget shift within the VU University and VU medical center, from input-based to output-based budgeting. 14

17 6. News & Highlights of the year 2010 Events Neuroscience Campus Amsterdam - Second Annual Meeting - 3 April 2010 Opening of new MEG facility at VUmc 31 May 2010 Science Center NEMO research on intelligence summer 2010 Opening of new Alzheimer Center VUmc by Queen Beatrix 28 September 2010 Valorization Meeting in ING house 19 October 2010 Honorary Doctorate for Prof. Dennis Selkoe, Harvard University at the VU/VUmc 20 October 2010 Marjo van der Knaap and Vivi Heine, in collaboration with FALW perform kickoff of the Stem Cell Facility 19 December 2010 Major Publication Output Boomsma & Penninx c.s. participate in Nature Genetics paper (IF = 34.3) Science paper (IF = 29.7) by the Sander Groffen & Matthijs Verhage Science paper by the Gajja Salomons & Prof. Marjo van Knaap Heidi de Wit & Matthijs Verhage participate in study published in Science Chris Polman participates in study published in Nature Medicine (IF = 27.1) Opinion leading perspective in Neuron by Sushant Jain & Peter Heutink (IF = 13.6) Fifteen additional papers in peer reviewed journals with Impact Factor of > 10 as primary and/or last/senior author(s) Forty two additional papers in peer reviewed journals with Impact Factor of > 10 as associated author(s) 48% of 453 papers in top 10% of International Journals 22% of papers in next segment of the top quartile (11-25%) of International Journals sorted on Relative Impact Factor Grants for individuals in 2010 VICI grant for Brenda Penninx Major external funding acquired in 2010 NWO TOP subsidy for Christel Middelkoop c.s. (500 k, research program Attention & Cognition) Stichting International Parkinson awards grant to NCA team-leaders Benjamin Druckarch, Anne-Marie van Dam and Wilma van de Berg. Brain & Cognition grant for Danielle Posthuma c.s. (600 k, research Integrative Analysis & Modelling) ZonMW Middelgroot subsidy to Marloes Groot & Huibert Mansvelder, c.s. (675 k, research program Photonics & Life Cell Imaging) ZonMW Middelgroot subsidy to Ronald van Kesteren & Guus Smit (675 k, research program Drugs Screening & Therapy Design) 15

18 ZonMW TOP subsidy for Niels Cornelisse c.s. (research Systems Biology of the Synapse) ENC-Network - Erasmus Mundus Joint Doctorate grant (6.7 M ) to Neuroscience Campus Amsterdam started ( ENC-Network Erasmus Mundus Master Course grant 1.25 M for the ENC-Network through work by Huibert Mansvelder & Arjen Brussaard ( SynSys - FP 7 grant (12 M of which 2.5 M for NCA) to Guus Smit (coordinator), Huibert Mansvelder & Matthijs (SynSys - research program Systems Biology of the Synapse, started in 2010 NeuroBasic PharmaPhenomics - FES grant support (Bsik) (13 M of which 4.8 M for NCA) to profs Arjen Brussaard (managing director), Matthijs Verhage, Guus Smit en Huibert Mansvelder, in collaboration with Synaptologics ( started in 2010 BBMRI - Biobanking Infrastructure: Biobanking and Biomolecular Resources Research Infrastructure to profs Jan Smit & Dorret Boomsma as coapplicants (chair Prof. GertJan van Ommen c.s. (total grant 22 M ; participation from Neuroscience Campus Amsterdam-part pending), started in 2010 MS Research Foundation grant of 2.5 M for research under coordination of Jeroen Geurts and Elga de Vries Additional 1.1 M donation to Polman & Geurts for MS research New Facilities Heidi de Wit updates EM facility with support of Neuroscience Campus Amsterdam and with matching of CNCR. Huibert Mansvelder & Marloes Groot built additional photonics setups for life cell imaging, including dyeless imaging using third harmonics microscopy (and published recently in PNAS) Van Kesteren & Guus Smit add on to the Cellomics facilities at FALW New stem cell facility under coordinatorship of Vivi Heine in FALW building Newly appointed professors Prof. John van Swieten newly appointed as research professor at VUmc Prof. Brenda Penninx appointed as full professor at VUmc Prof. Danielle Posthuma appointed as Fenna Diemer Lindeboom Professor at the VU 16

19 7. International Collaboration Implementation of newly established collaborations Prof. Philip Scheltens, representing the Alzheimer Center VUmc and the Neuroscience Campus Amsterdam, appointed as national coordinator Joint Programming (FP7 collaboration) CNCR and Synaptologics join in major FP7 collaboration called SynSys - coordinator Prof. Guus Smit ( CNCR and Synaptologics join in setting up and acquiring new FES consortium called NeuroBasic PharmaPhenomics - managing director Prof. Arjen Brussaard (see Neuroscience Campus Amsterdam sets up and coordinates the European Neuroscience Campus Network (ENC-Network), an Erasmus Mundus Joint Master Programme and Joint Doctorate Programme, aimed at funding > 125 new MSc students, in addition to > 50 new PhD projects. The estimate is that of around thirty of the newly appointed PhD students will graduate at VU/VUmc - director Prof. Arjen Brussaard (see 17

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21 8. Input Research Institute 8a) Funding Combined financial investments since the start of collaboration Since the start of the organization, the Neuroscience Campus Amsterdam was supported with significant starting grant by the CvB, RvB and the participating faculties. This starting grant has been invested in Support Facilities and Research Program activities, according to the principle that any investment from this starting grant is (at least) equally matched by financial support from the participating labs. Thus far towards the end of 2009, this type of financial strategy amounted to a combined funding of 3.2 M in Advanced Technology Programs (including 800 keuro for Photonics) 2.5 M in Innovation of Infrastructure of the Support Facilities (including 250 keuro for Genomics/Proteomics/Cellomics and 100 keuro for EM microscopy) 3.1 M in Research Projects (Meetfonds fase 1 and Centre Medical Systems Biology - granted in 2008 and matched by Neuroscience Campus) In addition, the collective and aggregate acquisition of external funding since then amounted to a major wave of awarded grants with many highlights (also in 2010, see section 6) and a cumulative sum of more than 22 M of external grant support in 2009 and ~ 30 M in 2010 (see below). In addition, thanks to embedding in the Neuroscience Campus Amsterdam, we participate in a number of major grants with (inter)national consortia that started in 2010 (such as the ENC-Network Erasmus Mundus Joint Doctorate grant 6.7 M, a number of FP7 grants including SynSys - 12 M, a FES-subsidy of 13 M for NeuroBasic PharmaPhenomics (see and the BBMRI grant of 22 M for Biobanking as mentioned previously). External Funding - Neuroscience Campus Amsterdam gs 2 gs 3 gs 4 (mix) Total Total Total Total ,939,262 18,172,132 3,534,291 29,645,685 6,594,300 13,580,420 2,576,000 22,750,720 3,533,146 6,449, ,165 10,909,000 Table 1 Acquisition of grants by collaborative efforts of the Neuroscience Campus Amsterdam - started in 2010 and compared to 2008 and 2009 acquisition. For further information, on acquisition per research program, see section 10b. In this overview, gs 2 is NWO funded research, gs3 is project funding from non-profit, ministries, FES & EU and gs4 is based on a mix of contract-research (for profit/industry) and donations/philanthropy. 19

22 8b) Fte per type of funding (research time) Total fte research (including PhD students) Type of funding gs 1 gs 2 gs 3 gs 4 mixed Total Total n.a Total n.a Total Total fte research PhD students Type of funding gs 1 gs 2 gs 3 gs 4 mixed Total Total n.a Total n.a Total Table 2 Total of research appointments. A total of > 400 scientists even excluding support and technical - contribute to this total. The research time per research program is split in section 10b. In this overview, gs2 is NWO funded research, gs3 is project funding from non-profit, ministries, FES & EU and gs4 is based on a mix of contractresearch (for profit/industry) and donations/philanthropy. For a full list of all coworkers see appendix 1. 20

23 8c) New PhD projects started 2010 In 2010, 36 new PhD projects were started. For a full list of all newly started projects and PhD students, see appendix 2. We are confident about the future perspectives of Neuroscience Campus Amsterdam, given the acquisition of the Erasmus Mundus Joint Doctorate (with in total 50 additional PhD projects to be appointed up to 2014, of which ~ 25 projects are primarily or in collaboration with the Neuroscience Campus Amsterdam) and the International Training Network (Marie Curie) called BrainTrain (with in total 12 additional PhD projects, all in executed in Neuroscience Campus Amsterdam labs). PhD projects newly started Table 3 Newly started PhD project in recent years. The boost in 2009 is explained by the start of BrainTrain. Currently around 50% of the project is funded by European grants. 21

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25 9. Output Research Institute 9a) Scientific Output Theses Scientific papers Rest DissA DissB DissC DissD Wp WpREF WpNR VP Total Books Chptrs Total Total Total Table 5 Aggregate of the output of Neuroscience Campus Amsterdam. The numbers of refereed papers (WpRef) has increased compared to 2008 and 2009, the number of books and bookchapters and non-sci contributions was deliberately lowered since then. A full list of publications published is outlined in appendix 3. Abbreviations: Theses A: Promotion VU/VUmc PhD-student at VU Theses B: Promotion external PhD-student at VU Theses C: Promotion VU/VUmc PhD-student at other university Theses D: Promotion external PhD-student at other university (promotor, co-promotor) Wp: Books/monographs/book chapters/proceedings WpRef: Scientific Papers refereed WpNR: Scientific Papers non-refereed WB: Books/monographs WBC: - Book chapters/proceedings VP: Professional publication 23

26 9b) Scientific Output Program leaders and Support Coordinators An historical overview of the published number of articles per year and the total number of citations each year to the aggregate of these papers published by the current program leaders of the Neuroscience Campus Amsterdam shows a solid growth in output and relevance of their output (see Fig 3 and 4). At the onset of the new era in which the Neuroscience Campus Amsterdam became operational (i.e. during 2008) all program leaders of the Neuroscience Campus together had a yearly output of research papers per year. In 2008 > 9600 citations were collected to the accumulation of these research papers. Currently, this aggregate output of program leaders has increased to 320 research papers, with over citations in The sum of all citations to publications published by our program leaders accumulates to > to a total of papers, being published as corresponding author and an average of ~ 30 citations per published article. If also 'coauthor' papers are included, the program leaders together have published 4293 peer reviewed publications and have collected > citations thus far. The average total number of papers published thus far, is > 195 papers per group leader. Shown below are two graphs indicating the historical progress - prior to and - during the last three years of Neuroscience Campus Amsterdam. Total number of citations per year Figure 3. Shown is an historical perspective on the cumulative production of SCI articles (i.e. excluding reviews) per year, authored by program leaders and support coordinators (and those alike) of the Neuroscience Campus Amsterdam workforce and produced at the VU/VUmc Campus. If all program committee members are analyzed this way, currently the cumulative yearly output is 453 papers per year (see section 9a). 24

27 Figure 4. Historical perspective on the number of citations to scientific articles (SCI journals excluding reviews) authored by program leaders and support coordinators (and those alike) and produced at the VU/VUmc Campus. If all program committee members are analyzed, this way currently the yearly total number of citations is > per year. Citation analysis of program committee members To further analyze the scientific output, we have also collected the aggregate data of our 50 tenured program committee members currently collaborating in - or contributing to - the main stream activities of the Neuroscience Campus Amsterdam. Citation analysis reveals that of all of the Neuroscience Campus Amsterdam, on average a total number of > 115 research articles has been produced per author, with on average a cumulative number of ~ 3200 citations per author, an average h-value of 25 and a CPP of > 25. If we analyze program leaders only, these numbers increase to ~ 195 research articles per author, with ~ 5800 citations per author, an h-value of 36 and a CPP of 29. Figure 5: Number of published papers (research papers only) per author. Analysis of tenured (i.e. program committee members, and those alike, including affiliated research but only) primarily affiliated with the Neuroscience Campus Amsterdam on the basis of ISI Web of knowledge cross-checked with Publish or Perish (Google Scholar). On average a member in our institute had published > 115 papers towards the end of

28 Figure 6: Total number of citations per author. Analysis of tenured in the same databases as in figure 5. On average each member currently has collected > 3200 citations in total. Figure 7: The 'h-value' analysis of tenured. Similar database search as for figures 5 and 6. Figure 8: Average number of citations per published paper for all tenured. Same type of database search as for figures

29 Figure 9: Relative distribution of 2010 SCI publications (453 in total) categorized according to Relative Impact Factor. Almost half (i.e. 48 %) of the current output belongs to the category of highest impact papers (i.e. top 10%). And 7 out 10 papers belong to the top quarter of SCI journal publications and thus have a journal Impact Factor of 4 or higher. See also Table 5 for comparison with the 2008 and 2009 scores. To be able to make a comparison to the research output of previous years we have also included data and percentile scores from 2009 and 2008 respectively (see Table 5). Percentage (%) of papers distributed to the quality of the research field Relative Impact Factor Quartile Category % of 2010 papers 2010 upper quartile % score in 2010 % of 2009 papers upper quartile % score in top 10 % % % % % % of 2008 papers 52 upper quartile % score in 2008 Table 5 Comparison of Relative Impact Factors scores in 2010 compared to 2009 and

30 9c) Indicators of esteem A shortlist of awards, more details on grants awarded, and listing of other indicators of esteem are outlined in appendix 4. 9d) Societal Impact As outlined in section 6, we have proposed the candidate for the Honorary Doctorate in 2010, Dennis Selkoe from Harvard University. In the prelude to this award celebration on 20 October 2010, we also organized a Valorization Symposium in the ING House, where the basis for our current valorization strategy was laid out. In general we focus on the biological mechanisms underlying common mental health and neurological brain diseases, applying the latest technology and thereby providing new perspectives on therapy. Finding the 'cause' of brain diseases, design its 'cure' and implement this to the level of 'patient care' are all at the core of our research ambition. Many of our research projects and plans are directly (or indirectly) related to 'brain diseases' programs. This includes the activities of the VUmc Alzheimer Center, the MS Center Amsterdam, the Center for Children with White Matter Disorders and the GGZBA-clinic affiliated patient research-programs for Anxiety and Depression disorders (NESDA) of the GGZBAclinic. In doing so, we also provide community services in relation to patient care (advise and information to care takers). Notably are two initiatives, one being the so-called planned MS-supportal (a virtual reception and internet-portal for MS patients) and one the planned Memory Clinic of the Alzheimer Center to be launched coming fall. Moreover many of our senior investigators publish in national professional journals, give layman-lectures by invitation and/or participate in education projects (see appendix 5). 28

31 10. Per Research Program 10a) Description Advanced Technology Programs Research Programs in short: Figure 10 Advanced Technology Research Programs. Innovation and development of the latest techniques are embedded in independent research programs that provide 'translational potential' (as indicated by the arrows) for newly developed project in 'adjacent' research programs where this new technology is being applied in a (pre)clinical settling. 29

32 ADVANCED TECHNOLOGY PROGRAMS Brain Imaging Research Program Committee: Adriaan Lammertsma (program leader) Dick Veltman (program leader) Frederik Barkhof Eco de Geus Kees Stam Ruud Verdaasdonk Modern neuroscience increasingly depends on advanced, state-of-the-art brain imaging techniques to characterize brain function and morphology in healthy subjects and in patients with neurological and psychiatric disorders. In addition, brain imaging is increasingly being used in animal models of disease. The VU/VUmc is unique in that it is the only academic center in the Netherlands that houses all major imaging technologies: o positron/single photon emission tomography (PET/SPECT) o magnetic resonance imaging (MRI), including a 3 Tesla functional MRI (fmri) and MR spectroscopy (MRS) o magneto-encephalography (MEG) and EEG, including MRI-compatible EEG o repetitive transcranial magnetic stimulation (rtms) o optical imaging Since state of the art applied research requires similarly advanced methodological expertise, the Brain Imaging program encompasses all methodological developments needed for pursuing advanced research goals in applied (clinical and preclinical) projects. The aims of the Brain Imaging research program in recent year were twofold. The first aim was to make optimal use of the extensive imaging facilities at the VU/VUmc campus, and to integrate these techniques with each other, wherever possible. The program instigates and performs methodological imaging research, in particular with regard to functional and structural connectivity, and molecular imaging. Second, the program aimed to function as a center of expertise, providing advice and if necessary assistance to scientists from other programs. Expertise in the field of imaging and imaging-analysis are two strongholds of the VUmc, and as such provide clinicians and neuroscientists in other research programs with a unique set of tools for non-invasive, in vivo investigations of the brain, both in humans and in animal models of disease. Neuroimaging is likely to be used not only for characterizing neural substrate of various neuropsychiatric disorders, but also for assessment of psychopathological traits cutting across diagnostic categories and for identification of endophenotypes, which may aid in understanding the genetic basis of these disorders. 30

33 Key Publications - Brain Imaging Braber, A. den, Ent, D. van t, Cath, D.C., Wagner, J., Boomsma, D.I. & Geus, E.J.C. de (2010). Brain activation during cognitive planning in twins discordant or concordant for obsessive compulsive symptoms. Brain, 133(10), (IF = 9.49) Hindriks R, Bijma F, van Dijk BW, Stam CJ, van der Werf YY, van Someren EJ, de Munck JC, van der Vaart AW. (2011) Data-driven modeling of phase interactions between spontaneous MEG oscillations. Hum Brain Mapp. Jan 10. [IF 6.2] Moraal, B., Elskamp, I.J. van den, Knol, D.L., Uitdehaag, B.M.J., Geurts, J.J.G., Vrenken, H., Pouwels, P.J.W., Schijndel, R.A. van, Meier, D.S., Guttmann, C.R.G. & Barkhof, F. (2010). Long- Interval T2-Weighted Subtraction Magnetic Resonance Imaging A Powerful New Outcome Measure in Multiple Sclerosis Trials. Annals of Neurology, 67(5), (IF = 9.31) Roosendaal, S.D., Schoonheim, M.M., Hulst, H.E., Sanz-Arigita, E.J., Smith, S.M., Geurts, J.J.G. & Barkhof, F. (2010). Resting state networks change in clinically isolated syndrome. Brain, 133, (IF = 9.49) Schuitemaker A, van der Doef TF, Boellaard R, van der Flier WM, Yaqub M, Windhorst AD, Barkhof F, Jonker C, Kloet RW, Lammertsma AA, Scheltens P, van Berckel BN. Microglial activation in healthy aging. Neurobiol Aging Nov 2 (IF 6.4) Steenweg ME, Vanderver A, Blaser S, Bizzi A, de Koning TJ, Mancini GM, van Wieringen WN, Barkhof F, Wolf NI, van der Knaap MS. Magnetic resonance imaging pattern recognition in hypomyelinating disorders. Brain 2010 Oct; 133(10) (IF 9.6) Tol, M.J. van, Wee, N.J.A. van der, Heuvel, O.A. van den, Nielen, M.M.A., Demenescu, L.R., Aleman, A., Renken, R., Buchem, M.A. van, Zitman, F.G. & Veltman, D.J. (2010) Regional Brain Volume in Depression and Anxiety Disorders. Archives of General Psychiatry, 67(10), (IF = 12.25) 31

34 ADVANCED TECHNOLOGY PROGRAMS Drugs Screening and Therapy Design Research Program Committee: Peter Heutink (program leader) Guus Smit (program leader) Marjo van der Knaap Adriaan Lammertsma Huibert Mansvelder Matthijs Verhage The aims of this advanced technology program are twofold: The first aim is to make optimal use of our growing potential in cellomics facilities, which currently include cell culture robots and automated fluorescence time lapse microscopy tools that allow for medium throughput screening of genetically modified celllines. The unique asset of this technology is that the Neuroscience Campus can offer new bioassays by taking gene polymorphisms or haplotypes selected in for instance Genome Wide Analyses (GWA) and model these directly at the cellular level to test the effect of genetic variation or mutations on for instance neuronal outgrowth or cell survival. Since this technology is automated and executed in multiwell plates, it allows for the focused testing of (small molecule) shrna librairies or compound libraries (in collaboration with for instance partners from TI- Pharma. The second aim is to set up a so-called stem-cell facility, and to implement and further investigate to potential of stem-cell therapy (first in mutant mouse models of Childhood White Matter Disorders and in the long run in human patients). The program s collaborative research projects concern screening of potential therapeutic compounds in view of neurodegenerative disease (grey matter) as well as while matter disorders. In particular through bundling of the newest insights into the genetic vulnerability toward grey or white matter disorders in cellular assays and combining these with drug (design) screening, will help us to achieve a number of truly translated objectives. Second, in particular for the devastating (and Mendelian genetic) child neurology disorders (but potentially in the long run also for more common diseases including MS) stem-cell therapy may be a serious option when it comes to curing the diseases. Highlights - Drugs Screening & Therapy Design The group of Prof. Marjo van der Knaap decided to set up a Stem Cell Lab, to a large extent being supported with the funding from her 2008 Spinoza Price. In the fall of 2010 this facility was finally realized in the FALW building and under coordination of dr. Vivi Heine. Facilitated by the Prinses Beatrix price for Prof. Peter Heutink, his group has started to use a multidisciplinary approach to confirm and characterize the biological relevance of risk factors and to identify all functionally interacting genes in the affected pathway by using a high throughput cellomics approach. The characterization of gene networks instead of single genes will help to identify those genes in the affected gene network that can best serve as lead targets for development of new therapeutic approaches. Key Publication - Drugs Screening & Therapy Design Jain, S. & Heutink, P. (2010). From Single Genes to Gene Networks: High-Throughput-High- Content Screening for Neurological Disease. Neuron, 68(2), (IF = 13.26) 32

35 ADVANCED TECHNOLOGY PROGRAMS Integrative Analysis & Modeling Research Program Committee: Danielle Posthuma (program leader) Mathisca de Gunst (program leader) Niels Cornelisse Jaap Heringa Klaus Linkenkaer-Hansen Pim van Nierop Arjen van Ooyen Sophie van der Sluis Aad van der Vaart The Integrative Analysis and Modeling program provides the essential expertise on modeling and data analysis for the Neuroscience Campus systems biology approach of the brain. It develops and assesses statistical methods and computational tools for the analysis of large, complex data sets. It also builds biology-based mathematical and computational models and designs modelbased statistical tools for model systems with a limited number of components that are used to unravel generic principles of the involved biological networks. The program has three aims: to develop novel research methodology for integrative research concerning large and complex data sets (Methods for Large Data Sets); to perform research aimed at developing innovative tools for dedicated mathematical and computational modeling and statistical analysis (Biologybased Modeling and Methods); to perform integrative analysis of data obtained from different disciplines and levels of data (Integrative Data Analysis) The program s collaborative research projects concern modeling and analysis of data in the areas of genetic epidemiology, gene expression analysis and gene network modeling, phenomics, and neuronal networks. The research will result in mathematical and computational models, statistical methods and data analysis tools for biological networks, as well as high-level bioinformatics algorithms, including the integration and collaborative annotation of -omic data, and optimization of statistical analyses in a cluster environment. It will also be instrumental in the transfer of technology and skills into -omic bioinformatics, and in design of experiments and predictive biology. Highlights - Integrative Analysis & Modeling In 2010, a so-called NWO Complexity-grant was awarded to Arjen van Ooyen & Jeroen Geurts. The project is entitled "Stability and rewiring in adaptive neuronal networks". The main research questions addressed include how specific functioning and connectivity emerges in developing neuronal networks and how it is maintained in the face of ongoing plasticity? The findings will be applied to shed light onto the poorly understood network degeneration in Multiple Sclerosis. In the same year, a second NWO Complexity-grant was awarded to Niels Cornelisse, Danielle Posthuma and Matthijs Verhage for a project entitled "Identification of synaptic gene networks in complex brain disorders using a Bayesian framework". Despite the fact that most brain 33

36 disorders are highly heritable it has been difficult to identify gene defects causing the disease. Most likely the expected complexity of these diseases, involving interactions between very many genes, hampered the identification of disease genes so far. In this project the investigators want to improve standard methods for identification of disease genes using Bayesian statistics. Bayesian approaches have been successfully applied to other complex problems like weather forecasting, stock market analysis and traffic prediction. Here the investigators will use a similar approach to characterize the gene networks that influence synaptic functioning. This project is expected to pave the way for new rational therapeutic strategies, exploiting the predictive power of a probabilistic network description. A third project awarded by NWO was awarded to Aart van der Vaart c.s. for a project entitled "Should Credibility Sets Instill Confidence?" From the project: 'The two main paradigms to express uncertainty in a statistical data analysis are confidence sets and credibility sets. These are both data-determined regions that are meant to contain the unknown quantity of interest with prescribed probability, say 95 %. The difference is in the interpretation of the probability. Confidence sets would contain the parameter of interest 19 out of 20 times if data were collected and analyzed under equal conditions. Credibility sets arise in a Bayesian statistical analysis and contain the parameter with probability 95% if this were generated according to a given prior distribution. In practice credibility sets are typically constructed from the 95% central elements in a simulation of the posterior distribution. Notwithstanding the increased popularity of Bayesian methods in the last decades, confidence sets are more widely accepted, as they do not depend on a prior distribution. Confidence and credibility sets differ little when the unknown parameter is a Euclidean vector and the signal to noise ratio is small, but can be very different in the other case. This proposal concerns the properties of credibility sets in the other case, semi- or nonparametric statistics, where the parameter is an unknown function.' Key Publication - Integrative Analysis & Modeling Binsl TW, Alders DJ, Heringa J, Groeneveld AB, van Beek JH. Computational quantification of metabolic fluxes from a single isotope snapshot: application to an animal biopsy. Bioinformatics Mar 1;26(5): (IF = 4.92 ) Furberg, H., Kim, Y.J., Dackor, J., Boerwinkle, E., Franceschini, N., Ardissino, D., Bernardinelli, L., Mannucci, P.M., Mauri, F., Merlini, P.A., Penninx, B.W.J.H., Smit, J.H., Vogelzangs, N., Boomsma, D.I., Geus, E.J.C. de, Vink, J.M., Willemsen, G., Tiemeier, H., Uitterlinden, A.G., Duijn, C.M. van, Maes, H.H., Audrain-McGovern, J., Posthuma, D., Thornton, L.M., Lerman, C., Kaprio, J., Rose, J.E., Ioannidis, J.P.A., Kraft, P., Lin, D.-Y. & Sullivan, P.F. (2010) Genome-wide meta-analyses identify multiple loci associated with smoking behavior. Nature Genetics, 42(5), (IF = 34.3) Roelfsema, P.R., Ooyen, A. van & Watanabe, T. (2010) Perceptual learning rules based on reinforcers and attention. Trends in Cognitive Sciences, 14(2), (IF = 11.7) Ruano D, Abecasis GR, Glaser B, Lips ES, Cornelisse LN, de Jong AP, Evans DM, Davey Smith G, Timpson NJ, Smit AB, Heutink P, Verhage M, Posthuma D. Functional gene group analysis reveals a role of synaptic heterotrimeric G proteins in cognitive ability. Am J Hum Genet Feb 12;86(2): (IF = 12.3) Van der Sluis S, Verhage M, Posthuma D, Dolan CV. Phenotypic complexity, measurement bias, and poor phenotypic resolution contribute to the missing heritability problem in genetic association studies. PLoS One Nov 10;5(11):e13929 (IF = 4.35) Van der Sluis, S, Kan, K.J. & Dolan, C.V. (2010). Consequences of a network view for genetic association studies. Behavioral and Brain Sciences, 33(2-3), (IF = 19.04) 34

37 ADVANCED TECHNOLOGY PROGRAMS Photonics and Life Cell Imaging Research Program Committee: Marloes Groot (program leader) Huibert Mansvelder (program leader) Johannes de Boer George Kraal Erwin Peterman Ruud Toonen In this research, the investigators develop integrated non-linear optical imaging systems consisting of an in vitro imaging platform and in vivo, whole animal, imaging platforms that make optimal use of shared versatile laser systems. Advancement in neuroscience research requires the development of techniques that enable in vivo visualization of individual neurons, neuronal networks, and synaptic contacts, with high spatial and temporal resolution and penetration depth, while these circuits are processing information. The development of new optical in vivo imaging modalities that have sub-cellular resolution will allow identification of novel biomarkers for early detection of brain disease. New optical tools can, in addition to identification of new biomarkers, also be developed to perturb and interfere with the progression of disease at very early (pre-clinical) stages. The ability to visualize neurons inside living brain tissue is a fundamental requirement in neuroscience and neurosurgery. Especially the development of a noninvasive probe of brain morphology with micrometer-scale resolution is highly desirable, as it would provide a noninvasive approach to optical biopsies in diagnostic medicine. Two-photon laser-scanning microscopy (2PLSM) is a powerful tool in this regard, and has become the standard for minimally invasive high-resolution imaging of living biological samples. However, while 2PLSM-based optical methods provide sufficient resolution, they have been hampered by the requirement for fluorescent dyes to provide image contrast. Here we demonstrate high-contrast imaging of live brain tissue at cellular resolution, without the need for fluorescent probes, using optical third-harmonic generation (THG). We exploit the specific geometry and lipid content of brain tissue at the cellular level to achieve partial phase matching of THG, providing an alternative contrast mechanism to fluorescence. We find that THG brain imaging allows rapid, noninvasive label-free imaging of neurons, white-matter structures, and blood vessels simultaneously. Furthermore, we exploit THG-based imaging to guide micropipettes towards designated neurons inside live tissue. This work is a major step towards label-free microscopic live brain imaging, and opens up possibilities for the development of laserguided microsurgery techniques in the living brain. In the coming years, this research program aims to bring this technique into the clinic. Based on the state of the art microscope technology described above, a prototype system will be developed that will be tested on laboratory animals at first and ultimately in the operating theatre during brain surgery. 35

38 Highlights - Photonics & Life Cell Imaging The groups of Marloes Groot, Ruud Toonen & Huibert Mansvelder have setup two major high end Laser Scanning Microscopy setups with funding in part provided by the Neuroscience Campus Amsterdam. Huibert Mansvelder and Marloes Groot were awarded in 2010 with NWO middelgroot-grant for their new technology of "Simultaneous photo-manipulation and non-linear optical imaging of single synapses and neuronal networks in intact brain." Key Publications - Photonics & Life Cell Imaging Witte S, Negrean A, Lodder JC, de Kock CPJ, Testa Silva G, Mansvelder HD*, Groot ML* (2011) Label-free live brain imaging and targeted patching with third-harmonic generation microscopy. PNAS U S A. 108(15): (*Shared senior authors) (IF = 9.43) Witte S, Salumbides M, Peterman EJG, Brakenhoff R, van Dongen G, Toonen R, Mansvelder HD, Groot ML (2009) Development of laser-based imaging systems for medical diagnostics. In: Ultrafast Phenomena XVI Springer Series in Chemical Physics, 2009, Volume 92, Part 12, Witte, S.M., Baclayon, M., Peterman, E.J.G., Toonen, R.F.G., Mansvelder, H.D. & Groot, M.L. (2009). Single-shot two-dimensional full-range optical coherence tomography achieved by dispersion control. Optics Express, 17(14), (IF = 3.3) 36

39 Genes & the Brain Research Programs in short: Figure 11 Genes & the Brain Research Programs. We have three main stream research programs in this area where mechanistic models based on the genetic makeup of the brain is the common denominator theme. The arrows indicate that the three research programs have strong translational links and in part shared expertise. 37

40 GENES & THE BRAIN Attention & Cognition Research Program Committee: Dorret Boomsma (program leader) Matthijs Verhage (program leader) Meike Bartels Niels Cornelisse Peter Heutink Jelle Jolles Huibert Mansvelder Hanne Meijers Rhiannon Meredith Pim van Nierop Tommy Pattij Brenda Penninx Danielle Posthuma Guus Smit Attention and cognition research is probably one of the most intensively studied topics in Neuroscience Research. A total of eight departments of three faculties have joined in the Attention & Cognition program. Researchers with different backgrounds, ranging from molecular genetics and biology to genetic epidemiology, psychology and clinical applications, contribute to this multidisciplinary program. This intense collaboration and the availability of unique resources, such as a large collection of twin families, well phenotyped longitudinal cohorts recruited from clinics throughout the Netherlands, novel animal models for attention and mental retardation and state of the art research facilities concentrated at one city campus, generates unique potential. Highlights - Attention & Cognition The resting-state questionnaire (RSQ): A paradigm shift in resting-state neuroimaging, under coordination of Klaus Linkenkaer-Hansen. The human brain generates complex patterns of activity and cognition during wakeful rest, but their relationship has remained largely unexplored. The team of Linkenkaer-Hansen has developed a self-report Resting-State Questionnaire (RSQ) of 50 five-point Likert items for rating feelings and thoughts during the classical eyes-closed rest condition. In the past year ( ) the RSQ was used in functional magnetic resonance imaging (fmri) to investigate links between cognition and brain activity during the resting state (RS). The RSQ data revealed large inter-individual differences in thoughts and feelings experienced by the participants during RS-fMRI imaging. As our instructions were 'typical' such differences are likely to occur in most RS measurements. PCA identified factors that were related to emotions ("I felt happy") or cognitive control ("I had difficulty holding on to my thoughts"). Independent component analysis identified distinct group-averaged networks of brain regions with temporally correlated BOLD signals, including RS networks such as the default mode and the executive networks. Importantly, the investigators observed that individual variation in resting-state cognition meaningfully explains individual variation within the fmri-derived functional brain networks. Thus, the RSQ could prove useful for shedding light on functional implications of genetic or disease-related variation in RS brain activity. Mouse model for Fragile X mental retardation: Over the last 12 months, the team of Rhiannon Meredith has continued to work on a research line using the transgenic mouse model for Fragile X mental retardation. This mouse has been shown to have mild spatial learning and 38

41 memory impairments. Two PhD students in this team, Julia Dawitz and Ioannis Kramvis have been investigating synaptic activity in the hippocampal and entorhinal cortex regions necessary for spatial learning. Using multiphoton calcium imaging and electrophysiology, their work focuses on early developmental stages of postnatal brain development. Their projects are integrated within the EC FP7 BrainTrain consortium, co-ordinated by the CNCR and the VU University Amsterdam. In a related study, Meredith c.s. published their results testing the effects of glutamatergic antagonists upon synaptic function in developing hippocampus of Fragile X model mice. They found these drugs could correct small changes in excitatory synaptic function but were restricted to a specific developmental time window. Presynaptic gene networks for ADHD and other common disorders: In 2010 the teams of Danielle Posthuma, Niels Cornelisse, Guus Smit, Peter Heutink and Matthijs Verhage have developed an integrated approach to identifying genetic networks underlying brain disorders. This has led to a publication in The American Journal of Human Genetics early 2010, two manuscripts submitted in October 2010 and several national and international invited lectures and keynote addresses. One of our major highlights was the finding that the network of genes that encode G-proteins is involved in human intelligence. In follow-up analysis from PhD student Chavarria-Siles we confirmed that G-proteins are specifically associated with grey matter volume changes in the medial frontal cortex, an area known to be involved in cognitive processing (manuscript currently under review). In addition, a successful grant (An integrated genomic approach to ADHD) was written for the NWO-NIHC initiative and currently two PhD students will continue the work on linking variation in genetic networks important to ADHD to variation in brain structure and function. The gene network approach is also carried out as part of the EU funded SynSys project. Genetics of ADHD in adults: In 2010, the Netherlands Twin Register under guidance of Dorret Boomsma c.s. was first to publish on the genetics of ADHD symptoms in adults, reporting significant heritability, that is however substantially lower in adults than in children. A follow-up study provided significant evidence for linkage for inattention and ADHD on chromosomes 18q q21.32 and 2p25.1. Currently NTR leads a consortium of 3 Dutch groups for metaanalysis of GWA of adult ADHD. Key Publications - Attention & Cognition Boomsma DI, Saviouk V, Hottenga JJ, Distel MA, de Moor MH, Vink JM, Geels LM, van Beek JH, Bartels M, de Geus EJ, Willemsen G. Genetic epidemiology of attention deficit hyperactivity disorder (ADHD index) in adults. PLoS One May 12;5(5):e10621 (IF = 4.35) Haworth, C.M.A., Wright, M.J., Luciano, M, Martin, N.G., Geus, E.J.C. de, Beijsterveldt, C.E.M. van, Bartels, M., Posthuma, D., Boomsma, D.I., Davis, O.S.P., Kovas, Y., Corley, R.P., DeFries, J.C., Hewitt, J.K., Olson, R.K., Rhea, S.-A., Wadsworth, S.J., Iacono, W.G., McGue, M., Thompson, L.A., Hart, S.A., Petrill, S.A., Lubinski, D. & Plomin, R. (2010). The heritability of general cognitive ability increases linearly from childhood to young adulthood. Molecular Psychiatry, 15(11), (IF = 15.04) Kello, C.T., Brown, G.D.A., Ferrer-i-Cancho, R., Holden, J.G., Linkenkaer-Hansen, K., Rhodes, T. & Orden, G.C. van (2010). Scaling laws in cognitive sciences. Trends in Cognitive Sciences, 14(5), (IF = 11.66) Meredith RM, de Jong R, Mansvelder HD (2011) Functional rescue of excitatory synaptic transmission in the developing hippocampus in Fmr1-KO mouse. Neurobiol Disease 41(1): (IF=4.625) Ruano D, Abecasis GR, Glaser B, Lips ES, de Jong APH, Evans DM, Davey Smith G, Timpson NJ, Smit AB, Heutink P, Verhage M, Posthuma D. Functional gene-group analysis reveals a role of synaptic heterotrimeric G-proteins in cognitive ability. Am J Hum Genet, 2010;86(2): (IF = 12.3) Ruano, D., Abecasis, G.R., Glaser, B., Lips, E.S., Cornelisse, L.N., Jong, A.P.H. de, Evans, D.M., Smith, D.G., Thimpson, N.J., Smit, A.B., Heutink, P., Verhage, M. & Posthuma, D. (2010). Functional Gene Group Analysis Reveals a Role of Synaptic Heterotrimeric G Proteins in Cognitive Ability. American Journal of Human Genetics, 86(2), (IF = 12.3) Saviouk V, Hottenga JJ, Slagboom EP, Distel MA, de Geus EJ, Willemsen G, Boomsma DI. ADHD in Dutch adults: Heritability and linkage study. Am J Med Genet B Neuropsychiatr Genet. 2011; 156(3): (IF = 3.48) Sluis, S. van der, Kan, K.J. & Dolan, C.V. (2010). Consequences of a network view for genetic association studies. Behavioral and Brain Sciences, 33(2-3), (IF = 19.04) 39

42 GENES & THE BRAIN Addictive Behavior Research Program Committee: Guus Smit (program leader) Ton Schoffelmeer (program leader) Huibert Mansvelder Brenda Penninx Sabine Spijker Dick Veltman Jacqueline Vink Taco De Vries This program addresses the development of drug and alcohol addiction as well as relapse to compulsive drug- and alcohol-seeking behavior during abstinence in both laboratory animals (rodents) and humans. The availability of operant animal models to study the motivational and cognitive aspects of addiction, the availability of advanced in vitro and in vivo neurophysiological techniques and that of state-of-the-art genomics/proteomics expertise in this program is unique. Moreover, the availability of genome-wide data in NESDA as well as the Dutch Twin Register allows us to identify genetic risk factors, whereas the application of brain imaging enables us to examine the motivational and cognitive aspects and pharmacotherapy of relapse behavior in humans. The investigators examine how individual differences in cognition (such as attention and impulsivity) and emotion (anxiety), primarily addressed in other research programs of the institute, determine the individual susceptibility to develop addictive behavior and the individual s risk to relapse to drug- and alcohol-seeking behavior during abstinence. In this respect, animal and human studies aimed to identify the genetic basis of addiction proneness (identification of vulnerability genes, including studies in twins), will be initiated. Animal studies address the psychopharmacology and neurobiology of cue-induced relapse to drug- and food-seeking behavior as well as that of extinction of drug/foodrelated memories during abstinence. Clinical studies are being performed in drug addicts, employing brain imaging (fmri) and pharmacotherapy, in order to examine the functional anatomy and pharmacotherapy of relapse behavior (predicted by animal studies). Major deliverables of this research are: Identification of genetic risk factors (polymorphisms) for the acquisition of nicotine, heroin and alcohol addiction. Identification of novel targets (e.g. synaptic proteins) for pharmacotherapeutical intervention of relapse to drug and/or alcohol consumption during abstinence. Identification of distinct impulsivity traits as treatable risk factors for the development of compulsive nicotine- and alcohol-seeking behavior. Synthesis and in vivo application of compounds targeting nicotine and glutamate receptors as putative future medicines. 40

43 Recent milestones reached include: Identification of extracellular matrix proteins involved in relapse behavior in rats. Identification of distinct SNPs exceeding genome-wide significance and associated with smoking initiation and cessation in humans. Identification of inhibitory control and impulsive choice as distinct vulnerability traits for the acquisition, extinction and relapse of nicotine, cocaine, heroin, alcohol and food-seeking behavior in rats. Identification of adolescence as a particularly vulnerable period for nicotineinduced neurocognitive alterations in the adult forebrain that mediate addictive behavior. Key Publications - Addictive Behavior Counotte D, Goriounova N, Li KW, Loos M, van der Schors R, Schetters D, Schoffelmeer ANM, Smit AB, Mansvelder HD, Pattij T (2011) Lasting synaptic changes underlie attention deficits caused by nicotine exposure during adolescence. Nature Neuroscience, in press. (IF = 14.3) Tobacco and Genetics Consortium (including Vink J, Geus E, Boomsma D, Hottenga JJ, Posthuma, D and Penninx BW). Genome-wide meta-analyses identify multiple loci associated with smoking behavior. Nat Genet 2010;42: (IF=34.5) Thorgeirsson et al. Consortium including Penninx, B.W., Boomsma, D.I. (2010). Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nature Genetics, 42(5), (IF = 34.3) Van den Oever MC, Lubbers BR, Goriounova NA, Li KW, Van der Schors RC, Loos M, Riga D, Wiskerke J, Stegeman M, Schoffelmeer ANM, Mansvelder HD, Smit AB, De Vries TJ, Spijker S (2010) Extracellular matrix plasticity and GABAergic inhibition of prefrontal cortex pyramidal cells facilitates relapse to heroin-seeking behavior. Neuropsychopharmacology 35, (IF = 7.0) Wiskerke J, Schetters D, van Es IE, van Mourik Y, den Hollander BR, Schoffelmeer ANM, Pattij T (2011) Opioid receptors in the nucleus accumbens Shell region mediate the effects of amphetamine on inhibitory control but not impulsive choice. Journal of Neuroscience 31, (IF = 7.2) 41

44 GENES & THE BRAIN Systems Biology of the Synapse Research Program Committee: Matthijs Verhage (program leader) Guus Smit (program leader) Niels Cornelisse Sander Groffen Marloes Groot Ronald van Kesteren Kawan Li Huibert Mansvelder Rhiannon Meredith Pim van Nierop Danielle Posthuma Sabine Spijker Oliver Stiedl Ruud Toonen Heidi de Wit The overall aim of this program is to understand molecular function and plasticity of the synapse in health and disease. In order to do so, the collaborating investigators aim at constructing protein interaction models (interactome) of the synapse that will be based on different conditions of synaptic function and on mouse knockouts of synaptic proteins. The synaptic interactome models are based on quantitative experimental data, which ultimately explain how a complex protein network drives synaptic functions in the brain and predicts its adaptive capacities in response to environmental cues, such as behavioral challenges and pharmacological interventions. Finally, knowledge about synaptic function is being integrated to study synaptic networks in vitro and in vivo. Specific objectives are to provide targets for synaptic modulation and to dissect disease phenotypes by identifying crucial nodes and connectivity of the network. In order to generate quantitative experimental data on proteins and protein states and to reveal crucial nodes of the complete synaptic system, the research apply genetic, behavioral and pharmacological intervention and analyze the perturbation outcome using synapse-wide proteomics, synapse physiology, life cell imaging techniques and electron microscopy. Between over twenty new projects were realized in which various technical approaches have been applied, ranging from whole synapse screens (itraq (quantitative) high-throughput MALDI-TOF) and subsynaptic protein complex analysis (immunoprecipitations and pull-down of tagged proteins) to biocore interaction analysis to derive kinetic parameters for proteins of interest, synaptic localization of proteins using confocal and electron microscopy. The loop between computational science and experimental neuroscience is being 'closed' by using several perturbation approaches, involving gene knockdown, over-expression, pharmacological agents, and the use of peptide 42

45 mimetics to test model robustness and refine parameters. Modeling the synapse will allow us to predict and test synapse function and the physiology of neuronal circuitry. This information is crucially needed to design future therapeutic strategies addressing the many brain disorders for which synaptic dysfunction is a central aspect. Hence a truly integrated experimental and theoretical systems approach is applied to reach the objectives. Highlight - Systems Biology of the Synapse In 2010 the team of Ronald van Kesteren and Prof. Guus Smit received a NWO-Middelgroot grant to invest in automated confocal cellular imaging and screening instrumentation. Highresolution confocal imaging, together with automated image acquisition and advanced online image analysis algorithms will be used for the systematic functional analysis genes and proteins that mediate synapse formation and synaptic plasticity in vitro. Impression of the new life cell imaging facility in this Systems Biology of the Synapse Program Key Publications - Systems Biology of the Synapse Engelhardt, J., Mack, V., Sprengel, R., Kavenstock, N., Li, K.W., Stern-Bach, Y., Smit, A.B., Seeburg, P.H. & Monyer, H. (2010). CKAMP44: A Brain-Specific Protein Attenuating Short-Term Synaptic Plasticity in the Dentate Gyrus. Science, 327(5972), (IF = 29.74) Groffen, A.J., Martens, S., Diez Arazola, R., Cornelisse, L.N., Lozovaya, N., Jong, A.P.H. de, Goriounova, N.A., Habets, R.L., Takai, Y., Borst, J.G., Brose, N., McMahon, H.T. & Verhage, M. (2010). Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release. Science, 327(5973), (IF = 29.74) Mohrman, R., Wit, H. de, Verhage, M., Neher, E. & Sørensen, J.B. (2010). Fast Vesicle Fusion in Living Cells Requires at Least Three SNARE Complexes. Science, 330(6003), (IF = 29.74) 43

46 Brain Disease Mechanisms Research Programs in short: Figure 12 Brain Disease Mechanisms Research Programs. Three main type of brain disorders are currently being investigated. Each of these research programs is based upon large groups of patient cohort and patient clinical activities. Transdisciplinary dialogue is guaranteed because most programs are being supervised by both clinical and preclinical research leaders. The aim of the Neuroscience Campus is further to provide strong translational links between the Genes & the Brain programs and expertise being developed and the patient diagnosis and therapy oriented programs. 44

47 BRAIN DISEASE MECHANISMS Anxiety & Depression Research Program Committee: Brenda Penninx (program leader) Eco de Geus (program leader) Zoltan Bochdanovits Dorret Boomsma Peter Heutink Odile van den Heuvel Adriaan Lammertsma Christel Middeldorp Guus Smit Jan Smit Oliver Stiedl Dick Veltman Matthijs Verhage The overall aim of the anxiety and depression program is to identify genomic regions and gene variants that mediate vulnerability to these affective disorders; to understand this vulnerability at the synaptic and brain systems level; to determine their interaction with age, sex and environmental challenges; and to use this understanding to explain the observed patterns of brain activity of behaving humans. Ongoing research has already linked clinical outcomes to neuroanatomy of postmortem tissue, autonomic nervous system and Hypothalamus-Pituitary-Axis function, serum markers such as vitamin D, inflammation, and (f)mri traits, as well as receptor characteristics obtained from GABA-ergic (flumazenil), dopaminergic (raclopride), and serotonergic PET ligands. By cross-linking these, and other novel endophenotypes to newly detected genetic variants for anxiety and depression the program will uncover part of the actual pathways from molecule to mind for these afflictions. Translational targets are improved diagnostics and prognostics, and stronger evidence-based and personalized therapeutic intervention. The program will provide new insights into pathophysiology of depression and suggest previously unsuspected etiologic pathways for these diseases. This will translate into better care for patients by improving early detection of individuals at risk, which is a critical concern for clinicians identifying new therapeutic targets developing targeted interventions based on genetically defined risk. Key Publications - Anxiety & Depression De Moor MH, Costa PT, Terracciano A, Krueger R, de Geus EJ, Toshiko T, Hartman C, Esko T, Madden PAF, Derringer J, Amin N, Willemsen G, Hottenga JJ, Distel MA, Uda M, Sanna S, Ferrucci L, Schlessinger D, McCrae RR, Spinhoven P, Penninx BW, Realo A, Metspalu A, Heath AC, Pergadia ML, Peng Lin AA, Grucza R, Räikkönen K, Widen E, Luciano M, Tenesa A, Houlihan LM, Davies G, Hansell NK, Medland SE, Wray NR, Wright MR, Aulchenko Y, Janssens ACJW, Oostra BA, Allik J, Abecasis GR, Deary IJ, Bierut L, Martin NG, Boomsma DI, van Duijn CM. Metaanalytic genome-wide association study in > individuals reveals new loci for the Five- 45

48 Factor Model (NEO-FFI) personality domains. Mol Psychiatry 2010; in press. (IF=12.5) Perlis, R.H., Huang, J., Purcell, S., Fava, M., Rush, A.J., Sullivan, P.F., Hamilton, S.P., McMahon, S., Schulze, T., Potash, J.B., Zandi, P.P., Willour, V.L., Penninx, B.W.J.H., Boomsma, D.I., Vogelzangs, N., Middeldorp, C.M., Rietschel, M., Nöthen, M.M., Cichon, S., Gurling, H., Bass, N., McQuillin, A., Hamshere, M.L., Craddock, N., Sklar, P. & Smoller, J.W. (2010). Genome-wide association study of suicide attempts in mood disorder patients. American Journal of Psychiatry, 167(12), (IF = 12.52) Spijker S, Van Zanten JS, De Jong S, Penninx BW, van Dyck R, Smit JH, Ylstra, B, Smit AB, Hoogendijk WJG. (2010) Molecular markers of Major Depressive Disorder based on stimulated gene expression in drug-naive blood samples. Biol Psychiatry 68: (IF=8.7) Tobacco and Genetics Consortium (including Vink J, Geus E, Boomsma D, Hottenga JJ, Penninx BW and Posthuma, D (2010) Genome-wide meta-analyses identify multiple loci associated with smoking behavior. Nat Genet 42:441-7 (IF=34.5) Tol, M.J. van, Wee, N.J.A. van der, Heuvel, O.A. van den, Nielen, M.M.A., Demenescu, L.R., Aleman, A., Renken, R., Buchem, M.A. van, Zitman, F.G. & Veltman, D.J. (2010). Regional Brain Volume in Depression and Anxiety Disorders. Archives of General Psychiatry, 67(10), (IF = 12.25) Van Tol ML, van der Wee NJA, van den Heuvel OA, Nielen MMA, Demenescu LR, Aleman A, Renken R, van Buchem MA, Zitman FG, Veltman DJ. Regional brain volume in depression and anxiety disorders. Arch Gen Psychiatry 2010; 67: (IF=14.3) Wray NR, Pergadia ML, Blackwood DH, Penninx BW, Gordon SD, Nyholt DR, Ripke S, Smit JH, Hottenga JJ, Willemsen G, Middeldorp C, de Geus EJ, Lewis CM, McGuffin P, Hickie IB, van den Oord EJ, Liu J, Macgregor S, McEvoy BP, Byrne EM, Medland SE, Henders AK, Heath AC, Montgomery GW, Martin NG, Boomsma DI, Madden PAF, Sullivan PF. Genome-wide association study of major depressive disorder: New results, meta-analysis, and lessons learned. Mol Psychiatry 2011; in press. (IF=12.5) 46

49 BRAIN DISEASE MECHANISMS Research Program Committee Philip Scheltens (program leader) Peter Heutink (program leader) Common clinical cohorts: Henk Berendse Wiesje van der Flier Research theme 1: Neuropathology and biomarker studies Wilma van de Berg Annemieke Rozemuller Research theme 2: Neurogenetics and pathogenetic mechanisms Guus Smit Pieter Voorn Research theme 3: NeuroImaging Adriaan Lammertsma Cees Stam Research theme 4: New therapeutic approaches Eric van Exel Erik Scherder This is a clinically oriented translational program. The main focus is to unravel the underlying often overlapping pathophysiologic substrates of the common neurodegenerative disorders with AD and PD as their most well known representatives. The classical forms of AD and PD are considered distinct diseases, but many patients show a large overlap in symptoms, pathology and genetic findings. To enable targeted drug therapies, an adequate characterization of the underlying pathology at protein level is needed. It has become clear that at a molecular level there are common denominators and that an integrated joint approach on neurodegenerative disease holds the best promise for unraveling the pathogenesis of these disorders. The translational component will be evidenced in a bidirectional approach by using biomarkers and clinical information from patients to guide the preclinical program and findings from cellular and genetic research can immediately be tested and validated in clinical samples. Common goals of this program are: o to further unravel the, possibly in part common, neuronal substrates, as well as neuropathological and pathogenetic mechanisms of the above mentioned disorders; o to develop early, preferably even presymptomatic, diagnostic markers; o to develop novel therapeutic approaches. 47

50 Among the current available resources, there is extensive expertise from clinic, patient cohorts (also collaborative with other centers), phenotyping (including imaging), biomarkers, (early)diagnostic markers, neuroanatomy, neuropathology, transcriptomics, proteomics, gene finding, functional characterization, cellular, animal models and therapeutic approaches. A translational research plan has been constructed according to four major disease lines in this program: Alzheimer (and related forms of dementia) Parkinson FrontoTemporal Lobar Degeneration Normal Aging Key Publications - Deerlin et al. Consortium including Heutink, P. (2010) Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP43 inclusions. Nature Genetics, 42(3), 234-U34 (IF = 34.28) Goos JDC, Henneman WJP, Sluimer JD, Vrenken H, Sluimer IC, Barkhof F, Blankenstein MA, Scheltens PH, Van der Flier WM. (2010) Incidence of cerebral microbleeds: A longitudinal study in a memory clinic population. Neurology 2010;74: (IF = 8.17) Jain, S. & Heutink, P. (2010). From Single Genes to Gene Networks: High-Throughput-High- Content Screening for Neurological Disease. Neuron, 68(2), (IF = 13.26) Dubois, B, Feldman, H.H., Jacova, C., Cummings, J.L., Dekosky, S.T., Barberger-Gateau, P., Delacourte, A., Frisoni, G., Fox, N.C., Galasko, D., Gauthier, S., Hampel, H., Jicha, G.A., Meguro, K., O'Brien, J., Pasquier, F., Robert, P., Rossor, M., Salloway, S., Sarazin, M., Souza, L.C. de, Stern, Y., Visser, P.J. & Scheltens, P. (2010). Revising the definition of Alzheimer's disease: a new lexicon. Lancet Neurology, 9(11), (IF = 18.12) Frisoni, G.B., Fox, N.C., Jack, C.R., Scheltens, P. & Thompson, P.M. (2010). The clinical use of structural MRI in Alzheimer disease. Nature Reviews Neurology, 6(2), (IF = 6.36) Munneke, M., Nijkrake, M.J., Keus, S.H., Kwakkel, G., Berendse, H.W., Roos, R.A., Borm, G.F., Adang, E.M., Overeem, S. & Bloem, B.R. (2010). Efficacy of community-based physiotherapy networks for patients with Parkinson's disease: a cluster-randomised trial. Lancet Neurology, 9(1), (IF = 18.12) 48

51 BRAIN DISEASE MECHANISMS White Matter Diseases Research Program Committee: Theme 1: Multiple sclerosis and other neuroinflammatory diseases Chris Polman (program leader and theme leader) Christien Dijkstra (theme leader) Frederik Barkhof (theme leader) Bernard Uitdehaag (vice theme leader) Elga de Vries Paul van der Valk Annette van der Goes (program coordinator) Theme 2: Childhood white matter diseases Marjo van der Knaap (program leader and theme leader) Gert Scheper (vice program leader) Cornelis Jakobs (theme leader) Gajja Salomons Jeroen Vermeulen (theme leader) Theme 1: Multiple Sclerosis (MS) The primary goal of the VUmc MS Center Amsterdam is to perform internationally distinctive MS research that allows better understanding and treatment of MS. The center has an excellent international reputation and is one of the top five MS research groups in the world. The MS Center Amsterdam is a multidisciplinary research center in which more than 100 experts of different disciplines within the VU university medical center (VUmc) cooperate to work on questions regarding the cause, cure and care of MS. The combination of fundamental and clinical research allows us to quickly apply new research developments in diagnosis and treatment of MS. Likewise, questions concerning the pathogenesis of the disease that arise in the clinic can be answered vice versa in collaboration with basic scientists. This MS Center is unique because it unites a comprehensive array of disciplines ranging from experimental laboratory research to clinical research. The researchers of the VUmc MS Center Amsterdam have more recently decided to join forces to devote their expertise and focus to understanding neurodegeneration in MS and to work towards identifying novel targets for future neuroprotective treatment. The leading hypothesis is that neurodegeneration is causal to clinical progression and cognitive decline in MS, and we propose that the development of neuroprotective strategies is a crucial next step in the treatment of the disease. Theme 2: Childhood white matter diseases The primary goal of the Center for Childhood White Matter Disorders (CWMDs) is to improve the diagnosis and understanding of CWMDs in order to develop better treatment. CWMDs comprise a group of disorders that can be divided 49

52 into acquired damage and genetic disorders. The genetic CWMDs can be divided in metabolic and non-metabolic. The Center for CWMDs combines diagnosis, treatment, research on disease mechanisms and development of novel therapies, both specific and symptomatic. The center is multidisciplinary with clinicians, clinical researchers and basic researchers with a broad range of expertises. This set-up facilitates easy interaction of specialists in different fields. The work of the center is greatly facilitated by a large database of information on patients from all over the world, their MRIs, DNA, body fluids, tissues and cell lines. This database is conditional for research on the etiology and pathophysiology of rare to extremely rare disorders. Optimization of symptomatic treatment is an important target, especially treatment of spasticity and loss of communication. Highlights - White Matter Disease, theme 1 Messages from the media about a possible breakthrough in the treatment of MS by intervening with presumed cervical venous insufficiency caused a lot of commotion under MS patients. Because of societal impact, and because scientific evidence supporting the venous insufficiency hypothesis was very thin, we decided to rapidly perform a pilot study on this topic. In May we completed this study and found that neck vein abnormalities were as common in people with MS as in healthy people. Moreover, the study showed that these variations did not impact the outflow of blood from the brain. This research was published in J Neurol Neurosurg Psychiatry in Oct 2010 (Epub). In June we organized an information day for MS patients of the VUmc. About 300 participants enrolled and we received very enthusiastic comments about this event. In October the VU medical center organized the sixth VUmc building walk which was a great success. The 870 participants have collected over 8000 for research by the MS Center Amsterdam. Stefan Roosendaal received both the Lucien Appel Prize of the European Society for Neuroradiology (ESNR) and the Lourens Penning Prize of the Dutch Society for Radiology for his article in the scientific journal Brain ( : ) on the use of functional magnetic resonance imaging (fmri) for measuring resting state brain activity in people with clinical isolated syndrome (CIS). Chris Polman received the Winkler medal of the Dutch Society of Neurology for his work on MS. In 2010 MS researchers of VUmc have together obtained more than 7 M for MS research. Several large projects are: o The MS center has received a program grant for 2.4 M. The grant (written by Elga de Vries and Jeroen Geurts) to further understand neurodegeneration in MS and to move towards neuroprotection in MS was awarded by the Netherlands MS Research Foundation o Jack van Horssen has received a prestigious Fellowship of 240 K from the Netherlands MS Research Foundation for his research on oxygen damage in the brains of people with MS. o Vincent de Groot from the department of rehabilitation received a grant of ZonMw of 1 M for research into the treatment of fatigue in MS o Chris Polman has received 1.1 M from a private foundation for research on neurodegeneration in MS, applying imaging and optical coherence tomography (OCT). Our excellent international position is also expressed in the large number of selected presentations and posters on the yearly MS congress ECTRIMS in Gothenburg (Sweden) in October of MS researchers of VUmc were selected for 3 invited reviews, 7 oral presentations and 13 posters. In October 2011 the international world congress of MS (ECTRIMS&ACTRIMS) will take place in the RAI in Amsterdam. Highlights - White Matter Disease, theme 2 In January 2010, Vivi Heine, a stem cell biologist, arrived to set up a stem cell laboratory in the Faculty of Earth and Life Sciences. In this laboratory research will be performed to develop glia progenitor transplantation for Vanishing White Matter (VWM). The finances for the laboratory 50

53 come from the Spinoza Award, VUmc, VU Faculty of Earth and Life Sciences, and private money. The official opening of the laboratory was December 17. In 2010 we completed the development of three mutant mouse models: two for VWM and one for megalencephalic leukoencephalopathy with subcortical cysts (MLC). We have bred the mice to homozygously mutant. These mice will be extremely important for our studies on disease mechanisms and for developing neural stem cell therapy for VWM. For VWM we have found that the genotype correlates with the phenotype and that both mutations have an influence (Neurology 2010). In collaboration with Prof. Chris Proud (Southampton) we have demonstrated that the remaining activity of the deficient enzyme, eif2b does not show any correlation with the phenotype, suggesting that eif2b may have other functions than guanine exchange activity in translation initiation. By studying autopsy brain tissue of VWM patients and controls we have obtained new insights into the mechanism of VWM at cellular level: a defect in the maturation of glia progenitor cells. Glia progenitors are increased in numbers in VWM white matter, but do not give rise to sufficient numbers of mature, functionally competent oligodendrocytes and astrocytes. We found an abnormal composition of the astrocytic cytoskeleton, which probably explains the morphological abnormalities and contributes to the dysfunction. These findings explain the lack of myelin deposition and diminished reactive gliosis in the presence of increased numbers of maturation deficient glia (J Neuropathol Exp Neurol 2010 and 2011). The defect in glia maturation appears to be a central problem in VWM. With glia progenitor transplantation we may be able to cure this problem. In 2010 we published a paper (in Human Mutation) concerning evidence for the existence of at least two types of the neurometabolic disorder D-2-hydroxyglutaric aciduria (D-2-HGA), a disorder characterized by supraphysiological levels of D-2-hydroxyglutarate (D-2-HG) in body fluids: D-2-HGA Type I, an autosomal recessive form caused by mutations in D2HGDH, and an idiopathic form. A few months after this publication, we identified the underlying genetic defect for the idiopathic form and denoted it D-2-HGA type II. It is caused by heterozygous mutations in isocitrate dehydrogenase 2 (IDH2). Mutations in the latter gene were recently reported by others to occur as somatic mutations in several types of cancer. These mutations not only disable the enzyme's normal ability to convert isocitrate to 2-ketoglutarate (2-KG), but also result in a gain of function concerning the ability to convert 2-KG to D-2-HG. We have reported our finding of de novo heterozygous germline mutations in IDH2 in 15 unrelated D-2- HGA Type II patients in Science. In 2001, we identified MLC1 as the first gene for MLC. In 2010 we published that MLC patients without MLC1 mutations present with two distinct phenotypes (Ann Neurol 2010). One is the classical phenotype with slow neurological deterioration. The other is an improving phenotype in which the white matter disease improves or normalizes and in which neurological deterioration is lacking. The patients have macrocephaly, but are otherwise normal or have a mental retardation with or without autism. In collaboration with Prof. Raúl Estévez (Barcelona) we found the second gene for MLC, HEPACAM, which codes for hepatic and glial cell adhesion molecule, GlialCAM. The different phenotypes are related to different mutations with different modes of inheritance: autosomal recessive and autosomal dominant. With this, we have also found a gene for benign familial macrocephaly and for macrocephaly with mental retardation +/- autism. A paper on the subject has been accepted by the American Journal of Human Genetics (2011). Key Publications - White Matter Diseases, theme 1 Axtell RC, de Jong BA, Boniface K, van der Voort LF, Bhat R, De Sarno P, Naves R, Han M, Zhong F, Castellanos JG, Mair R, Christakos A, Kolkowitz I, Katz L, Killestein J, Polman CH, de Waal Malefyt R, Steinman L, Raman C. T helper type 1 and 17 cells determine efficacy of interferonbeta in multiple sclerosis and experimental encephalomyelitis Nat Med Apr;16(4): (IF = 27.13) Geurts, J.J.G., Kooi, E.J., Witte, M.E. & Valk, P. van der (2010). Multiple Sclerosis as an "Inside-Out" Disease. Annals of Neurology, 68(5), (IF = 9.31) Killestein, J., Vennegoor, A., Strijbis, E.M.M., Seewann, A.M., Oosten, B.W. van, Uitdehaag, B.M.J. & Polman, C.H. (2010). Natalizumab Drug Holiday in Multiple Sclerosis: Poorly Tolerated. Annals of Neurology, 68(3), (IF = 9.31) Moraal B, van den Elskamp IJ, Knol DL, Uitdehaag BM, Geurts JJ, Vrenken H, Pouwels PJ, van Schijndel RA, Meier DS, Guttmann CR, Barkhof F. Long-interval T2-weighted subtraction 51

54 magnetic resonance imaging: a powerful new outcome measure in multiple sclerosis trials. Ann Neurol May;67(5): (IF = 9.31) Moraal, B., Elskamp, I.J. van den, Knol, D.L., Uitdehaag, B.M.J., Geurts, J.J.G., Vrenken, H., Pouwels, P.J.W., Schijndel, R.A. van, Meier, D.S., Guttmann, C.R.G. & Barkhof, F. (2010). Long- Interval T2-Weighted Subtraction Magnetic Resonance Imaging A Powerful New Outcome Measure in Multiple Sclerosis Trials. Annals of Neurology, 67(5), (IF = 9.31) Petzold, A.F.S., Boer, J.F. de, Schippling, S., Vermersch, P., Kardon, R., Green, A., Calabresi, P.A. & Polman, C.H. (2010). Optical coherence tomography in multiple sclerosis: a systematic review and meta-analysis. Lancet Neurology, 9(9), (IF = 18.12) Polman, C.H., Bertolotto, A., Deisenhammer, F., Giovannoni, G., Hartung, H.P., Hemmer, B., Killestein, J., McFarland, H.F., Oger, J., Pachner, A.R., Petkau, J., Reder, A.T., Reingold, S.C., Schellekens, H. & Sorensen, P.S. (2010). Recommendations for clinical use of data on neutralising antibodies to interferon-beta therapy in multiple sclerosis. Lancet Neurology, 9(7), (IF = 18.12) Key Publications - White Matter Diseases, theme 2 Kranendijk M, Struys EA, van Schaftingen E, Gibson KM, Kanhai WA, van der Knaap MS, Amiel J, Buist NR, Das AM, de Klerk JB, Feigenbaum AS, Grange DK, Hofstede FC, Holme E, Kirk EP, Korman SH, Morava E, Morris A, Smeitink J, Sukhai RN, Vallance H, Jakobs C, Salomons GS. (2010) IDH2 mutations in patients with D-2-hydroxyglutaric aciduria. Science 330: 336 (IF 29.7) van der Knaap MS, Lai V, Köhler W, Salih MA, Fonseca MJ, Benke TA, Wilson C, Jayakar P, Aine MR, Dom L, Lynch B, Kálmánchey R, Pietsch P, Errami A, Scheper GC. (2010) Megalencephalic leukoencephalopathy with cysts without MLC1 defect. Ann Neurol 67: (IF 9.3) 52

55 10b) Input per program fte per type of funding (incl PhD students) gs 1 gs 2 gs 3 gs 4 Total Total Total Advanced Technology Brain Imaging Drugs Screening & Therapy Design Integrative Analysis & Modeling Photonics & Life Cell Imaging Genes & the Brain Attention & Cognition Addictive Behavior Systems Biology of the Synaps Brain Disease Mechanisms Anxiety and Depression White Matter Disease Affliated research n.a. Total fte PhD students per type of funding gs 1 gs 2 gs 3 gs 4 Total Total Total Advanced Technology Brain Imaging Drugs Screening & Therapy Design Integrative Analysis & Modeling Photonics & Life Cell Imaging Genes & the Brain Attention & Cognition Addictive Behavior Systems Biology of the Synaps Brain Disease Mechanisms Anxiety and Depression White Matter Disease Affliated research n.a. Total Table 6 - Input in fte per Research Program. A full list of coworkers is outlined in appendix 1. 53

56 10b) Input per program (continued) External Funding gs 2 gs 3 gs 4 Total Total Erasmus Mundus & Dissemination 5,000 3,450, ,455,000 0 Advanced Technology Brain Imaging Drugs Screening & Therapy Design Integrative Analysis & Modeling Photonics & Life Cell Imaging Genes & the Brain Attention & Cognition Addictive Behavior Systems Biology of the Synapse Brain Disease Mechanisms Anxiety & Depression White Matter Disease Affiliated Research 0 219, ,508 1,069, ,675,000 1,010, ,010, , , , ,513 2,551, ,063,513 1,153, , ,000 2,783, ,000 3,697, ,547,000 4,972,369 2,498,000 1,950, ,000 4,895,960 5,435,000 1,033,000 1,231, ,215 2,479,026 1,538,342 1,000,000 5,036,853 2,825,076 8,861,929 3,000, ,000 35,000 48, , ,000 Table 7 Grant acquisition per Research Program of 2010 compared to Acquisition is split in types of funding. The funding coming from Erasmus Mundus for PhD s at NCA in the ENC-Network, is estimated to be half to the total EU-acquisition for the coming five years. A full list of acquired external funding is outlined in appendix 6. In this overview, gs2 is N.W.O. funded research, gs3 is project funding from non-profit, ministries, FES & EU and gs4 is based on a mix of contract-research (for profit/industry) and donations/philanthropy. 54

57 10c) Output per program Scientific Output Theses Scientific papers Rest DissA DissC DissB DissD Wp WpREF WpNR VP Total Total Books Chapters Advanced Technology Brain Imaging Drugs Screening & Therapy Design Integrative Analysis & Modeling Photonics & Life Cell Imaging Genes & the Brain Attention & Cognition Addictive Behavior Systems Biology of the Synaps Brain Disease Mechanisms Anxiety and Depression White Matter Disease Affliated research Table 8 - Output in 2010 per Research Program of the Neuroscience Campus Amsterdam. A full list of publications is outlined in appendix 3. Also listed are the total output numbers (primarily determined by the WpREF) of previous year. Abbreviations: Theses A: Promotion VU/VUmc PhD-student at VU Theses B: Promotion external PhD-student at VU Theses C: Promotion VU/VUmc PhD-student at other university Theses D: Promotion external PhD-student at other university (promotor, co-promotor) WP: Books/monographs/book chapters/proceedings WP Ref: Scientific Papers refereed WP NR: Scientific Papers non-refereed VP: Professional publication 55

58 10c) Output per program (continued) % of papers in 2010 with RIF* of 5 % of papers in 2010 with RIF of 4 % of papers in 2010 with RIF of 3 % of papers in 2010 with RIF of 2 % of papers in 2010 with RIF of 1 total number of papers up to en of 2010 total number of citations up to end of 2010 average CPP towards the end of 2010 mean h - index of tenured end of 2010 Advanced Technology Brain Imaging 44% 24% 20% 12% 0% Drugs Screening & Therapy Design n.a Integrative Analysis & Modeling 38% 38% 17% 8% 0% Photonics & Life Cell Imaging n.a Genes & the Brain Attention & Cognition 59% 25% 14% 2% 2% Addictive Behavior 68% 5% 21% 5% 0% Systems Biology of the Synapse 46% 35% 19% 0% 0% Brain Disease Mechanisms Anxiety & Depression 74% 17% 6% 3% 0% % 14% 30% 5% 0% White Matter Disease 45% 19% 31% 5% 3% Affliated Research 44% 24% 20% 12% 0% * RIF = Relative Impact Factor Quartile Category: 5: top 10% 4: 11-25% 3: 26-50% 2: 51-75% 1: % Table 9 - Quality of the Program Committee per Research Program. Shown are total number of papers by Program Committee Members per Program, the Cumulative Number of Citations per group of authors, the average CPP and mean h-index. In addition, in the first five columns, per research program the % of 2010 papers categorized according to the RIF, Relative Impact Factor is shown. 56

59 11. Scientific Research Committees Quality control at the Neuroscience Campus Amsterdam is done by three internal committees, one for Biomedical Research (CWO-FALW), one for Psychology Research (CWO-FPP), and one for Medical Research (CWO-VUmc) and an external Scientific Advisory Board (chaired by Prof. Martinus Niermeijer - for more information, see our website). The chairs of the different committees meet twice a year with Management Team and moreover are involved in screening internal projects. We follow the VSNU accredited academic evaluation cycle with a Self-evaluation (Midterm) Review in 2011 and External Audit in

60 Exchange Honours students of Master of Neurosciences Amsterdam-Rotterdam (director Gerard Borst & Huibert Mansvelder) Graduate School Neurosciences Amsterdam Rotterdam (director August Smit) PhD training in Europe - ITN (coordinator Heidi de Wit) MSc & PhD training in Europe - Erasmus Mundus funded programs (director - Arjen Brussaard) 58

61 12. Education & Training Graduate Training: Since 2002 the group/team leaders currently involved in the Neuroscience Campus Amsterdam organize graduate training in a 2-year research program, the Master of Neuroscience. In this successful program, which selects students coming from various bachelor backgrounds from the international community, we train our future PhD-students. Moreover in 2005 we started an additional Exchange Honours Program for excellent students coming from our campus, and those being selected in the Erasmus MC program. More recently, in 2008, also the Netherlands Institute for Neurosciences joined in supervision of this exchange master program. The VU holds the chair of the ECOS accredited Graduate School Neuroscience Amsterdam Rotterdam (ONWAR) and in doing so is taking the lead in organizing PhD-student training in the field of Neurosciences in Amsterdam (VU/VUmc, NIN and UVA/AMC) and Rotterdam (Erasmus MC). Master of Biomedical Sciences Senior of the Neuroscience Campus Amsterdam is supervising new education courses and programmes in the field of Human Genetics (see our website for more information). Master of Neurosciences We organize a two year Research Master of Neuroscience Program. Students coming from various bachelor backgrounds from the international community enter the program. The ambition is clear: we train our future PhD-students. (see our website for more information). PhD training in Amsterdam-Rotterdam This program is offered by collaborating Neuroscience Institutes in Amsterdam and Rotterdam (see our website for more information). ITN Marie Curie - Brain-Train At the Neuroscience Campus Amsterdam, we offer facilities to several International Training Networks, most recently to a training network called BrainTrain (under supervision by Heidi de Wit). Erasmus Mundus - ENC-Network In addition, we are well connected in the so-called ENI network and have started in the European Neuroscience Campus Network (see of which our director, Arjen Brussaard is the founding director. During the first months of 2010 we recruited 12 new PhD students who have started their PhD training in October In total until 2014 we intend to recruit over > 50 new PhD students in this network. 59

62 60 Annual Report 2010

63 Appendices 1. Scientific input Newly started PhD project Scientific output Indicators of esteem Societal impact Acquisition per type of funding

64 62 Annual Report 2010

65 Appendix 1: Scientific input Advanced Technology Programs: BRAIN IMAGING funding fte Title Name Department Funding type Tenured Barkhof F. Radiology 1 VUmc 0,10 Tenured Boellaard R. Nuclear Medicine & 1 VUmc 0,30 PET Research Tenured Ent D. van 't Biological Psychology 1 FPP 0,80 Tenured Geus J.C.N. de Biological Psychology 1 FPP 0,05 Tenured Lammertsma A.A. Nuclear Medicine & 1 VUmc 0,20 PET Research Tenured Molthoff C.F.M. Nuclear Medicine & 1 VUmc 0,20 PET Research Tenured Munck J.C. de Physics and Medical 1 VUmc 0,70 Technology Tenured Pouwels P.J.W. Physics and Medical 1 VUmc 0,20 Technology Tenured Stam C.J. Neurology 1 VUmc 0,20 Tenured Veltman D.J. Psychiatry 1 VUmc 0,20 Tenured Verdaasdonk R.M. Physics and Medical 1 VUmc 0,10 Technology Tenured Windhorst A.D. Nuclear Medicine & 1 VUmc 0,20 PET Research Berckel B.N.M. van Nuclear Medicine & 1 VUmc 0,10 PET Research Dijk B.W. van Physics and Medical 1 VUmc 0,40 Technology Herscheid J.D.M. Nuclear Medicine & 1 VUmc 0,20 PET Research Heuvel O.A. van den Psychiatry 1 Vumc Psych GGZ 0,10 Hillebrand A. Neurology, Clinical 1 VUmc 0,20 Neurophysiology Huisman M.C. Nuclear Medicine & 1 VUmc 0,30 PET Research Kuijer J.P.A. Physics and Medical 1 VUmc 0,10 Technology Lubberink J.M. Nuclear Medicine & 1 VUmc 0,30 PET Research Sanz-Arigita E.J. Radiology 1 VUmc 0,50 Wink A.M. Radiology 1 VUmc 0,20 Christiaans J.A.M. Nuclear Medicine & 2 1,00 PET Research Cover K.S. Physics and Medical 2 NEU Grid 0,50 Technology Heuvel O.A. van den Psychiatry 2 NWO 0,10 Metaxas A. Nuclear Medicine & 2 0,92 PET Research Smit D.J.A. Biological Psychology 2 NWO 0,30 Eersels J.L.H. Nuclear Medicine & 3 0,20 PET Research Eriksson P.A.J. Nuclear Medicine & 3 0,50 PET Research Postnov A. Nuclear Medicine & 3 0,71 PET Research Tolboom N. Nuclear Medicine & 3 0,40 PET Research Wink A.M. Radiology 3 0,20 Sanz-Arigita E.J. Radiology 4 gemengd 0,50 PhD student Veen A.J. van der Physics and Medical Technology 1 VUmc 0,10 63

66 PhD student Al Hussainy R. Nuclear Medicine & 2 CW/STW 0,75 PET Research PhD student Gerrits N.J.H.M. Anatomy and 2 0,13 Neurosciences PhD student Mourik J.E.M. Nuclear Medicine & 2 NWO 0,75 PET Research PhD student Wit S. de Psychiatry 2 0,80 PhD student Klein P.J. Nuclear Medicine & 3 0,75 PET Research PhD student Schoonheim M.M. Radiology 3 St.MSR 0,23 PhD student Verbeek J. Nuclear Medicine & 3 0,75 PET Research PhD student Binnewijzend M.A.A. Radiology 4 0,25 PhD student Born D. van der Nuclear Medicine & PET Research 4 IAC/St Alz 0,56 Advanced Technology Programs: DRUGS SCREENING & THERAPY DESIGN funding fte Title Name Department Funding type Tenured Heutink P. Clinical Genetics and 1 VUmc 0,10 Antropgenetics, Medical Genetics Tenured Mansvelder H.D. Integrative 1 FALW 0,01 Neurophysiology Tenured Smit A.B. Molecular and Cellular Neurobiology 1 FALW 0,01 Jain S. Clinical Genetics and Antropgenetics, Medical Genetics 3 VUmc 0,50 Advanced Technology Programs: INTEGRATIVE ANALYSIS & MODELING funding fte Title Name Department Funding type Tenured Bijma F. Mathematics 1 FEW 0,15 Tenured Bochdanovits Z. Clinical Genetics 1 VUmc 0,10 and Antropgenetics, Medical Genetics Tenured Gunst M.C.M. Mathematics 1 FEW 0,20 Tenured Hottenga J.J. Biological 1 FPP + EU 0,25 Psychology Tenured Jonker M.A. Mathematics 1 FEW 0,15 Tenured Posthuma D. Clinical Genetics 1 VUmc 0,10 and Antropgenetics, Medical Genetics Tenured Vaart A.W. van der Mathematics 1 FEW 0,10 Tenured Wiel M.A. van der Mathematics 1 FEW 0,05 Tenured Wieringen W. van der Mathematics 1 FEW 0,05 Tenured Posthuma D. Functional Genomics 2 NWO 0,18 Tenured Posthuma D. Biological 2 NWO 0,03 Psychology Tenured Hottenga J.J. Biological 3 FPP + EU 0,25 Psychology Geeven G. Mathematics 1 FEW/NCA 0,05 Hardstone R.E. Integrative 1 NCA/CvB 0,75 Neurophysiology Hindriks R. Mathematics 1 FEW 0,56 Jansen R. Integrative 1 FALW 0,61 Neurophysiology Linkenkaer- Hansen K. Integrative Neurophysiology 1 FALW 0,20 64

67 Ooyen A. van Integrative 1 FALW 0,20 Neurophysiology Pardo L.M. Clinical Genetics 1 VUmc 0,50 and Antropgenetics, Medical Genetics Pecanka J. Mathematics 1 FEW 0,37 Geeven G. Mathematics 2 FEW 0,70 Leday G. Mathematics 2 FEW 0,20 Pecanka J. Mathematics 2 FEW 0,38 Ridder A. de Integrative 2 NWO 0,15 Neurophysiology Ros B. Mathematics 2 FEW 0,19 Tarigan B. Mathematics 2 FEW 0,60 Baljon P.J. Integrative 3 SECO 0,75 Neurophysiology Bevova M.R. Clinical Genetics 3 0,10 and Antropgenetics, Medical Genetics Butz M. Integrative 3 CompLifeScie 0,90 Neurophysiology Carnell A. Integrative 3 SECO/EU 0,90 Neurophysiology Hjorth J. Integrative 3 CompLifeScie 0,90 Neurophysiology Olde Scheper T. Integrative 3 SECO/EU 0,90 Neurophysiology PhD student Diaz A. Integrative 1 FALW 0,38 Neurophysiology PhD student Groen M. Integrative 2 NWO 0,38 Neurophysiology PhD student Poil S.S. Integrative 2 NWO 0,50 Neurophysiology PhD student Watling L.A. Integrative 2 NWO 0,90 Neurophysiology PhD student Avella Gonzales O.J. Integrative Neurophysiology 3 Neurovers/EU 0,75 Advanced Technology Programs: PHOTONICS & LIFE CELL IMAGING funding fte Title Name Department Funding type Tenured Boer J. Natuurkunde 1 FEW 0,10 Tenured Groot M.L. Natuurkunde 1 FEW 0,30 Tenured Iannuzzi D. natuurkunde 1 FEW 0,05 Tenured Mansvelder H.D. Integrative 1 FALW 0,10 Neurophysiology Tenured Meredith R.M. Integrative 1 FALW 0,04 Neurophysiology Tenured Peterman E.J.G. Natuurkunde 1 FEW 0,10 Tenured Stokkum I. van Natuurkunde 1 FEW 0,00 Tenured Wijngaarde R. natuurkunde 1 FEW 0,00 Tenured Wuite G. natuurkunde 1 FEW 0,05 Groot M. Natuurkunde 1 FEW 0,10 Meredith R.M. Integrative 1 FALW 0,23 Neurophysiology Witte S. Natuurkunde 1 NCA/FEW 0,50 PhD student Negrean A. Integrative Neurophysiology 3 ERC/VU 0,37 65

68 Genes and the Brain: ATTENTION & COGNITION funding fte ititle Name Department Funding type Tenured Heutink P. Clinical Genetics and 1 VUmc 0,10 Antropgenetics, Medical Genomics Tenured Linkenkaer- K. Integrative 1 FALW 0,20 Hansen Neurophysiology Tenured Mansvelder H.D. Integrative 1 FALW 0,04 Neurophysiology Tenured Meredith R.M. Integrative 1 FALW 0,03 Neurophysiology Tenured Mulder A.B. Anatomy and 1 VUmc 0,40 Neurosciences Tenured Pattij T. Anatomy and 1 VUmc 0,40 Neurosciences Tenured Posthuma D. Clinical Genetics and 1 VUmc 0,50 Antropgenetics, Medical Genomics Tenured Smit A.B. Molecular and Cellular 1 FALW 0,04 Neurobiology Tenured Spijker S. Molecular and Cellular 1 FALW 0,04 Neurobiology Tenured Verhage M. Functional Genomics 1 VU/VUmc 0,05 Tenured Kock C. de Integrative 2 NWO 0,40 Neurophysiology Tenured Posthuma D. Biological Psychology 2 NWO 0,02 Tenured Bartels M. Biological Psychology 3 VUMC 0,20 Tenured Boomsma D.I. Biological Psychology 3 EU 0,05 Meredith R.M. Integrative 1 FALW 0,22 Neurophysiology Min J.L. Functional Genomics 1 NCA 0,13 Polderman (T.)J.C. Functional Genomics 1 VU/NCA 0,60 Rizzu P. Clinical Genetics and Antropgenetics, Medical Genomics 1 VUmc 0,10 Min J.L. Functional Genomics 2 NWO 0,12 Sluis S. van der VUmc, KG, FGA 2 NWO 0,70 Smit D.J.A. Biological Psychology 2 NWO 0,30 Heistek T. Integrative 3 ERC/VU 0,90 Neurophysiology Savyuk S Biological Psychology 3 EU 0,40 Therpurakal R. Integrative 3 MPI 0,90 Narayanan Neurophysiology PhD student Aarts E. Functional Genomics 1 VU 0,25 PhD student Boer M. de Anatomy and 1 VUmc 0,75 Neurosciences PhD student Diaz A. Integrative 1 FALW 0,38 Neurophysiology PhD student Posthuma D. Functional Genomics 1 VU 0,18 PhD student Rizzi T.S. Functional Genomics 1 VU 0,38 PhD student Rizzi T. Biological Psychology 1 FPP 0,08 PhD student Bloem B. Integrative 2 NWO 0,75 Neurophysiology PhD student Boudewijns Z. Integrative 2 NWO 0,75 Neurophysiology PhD student Chavarría Síles I.M. Functional Genomics 2 NWO 0,75 PhD student Nivard M. Biological Psychology 2 NWO 0,04 PhD student Poil S.S. Integrative 2 NWO 0,25 Neurophysiology PhD student Rizzi T.S. Functional Genomics 2 NWO 0,37 66

69 PhD student Soelen I.L.C. van 't Biological Psychology 2 NWO 0,90 PhD student Vinkhuyzen A.A.E. Functional Genomics 2 NWO 0,25 PhD student Vinkhuyzen A.E. Biological Psychology 2 NWO 0,08 PhD student Abdelloui A. Biological Psychology 3 CMSB 0,45 PhD student Dawitz J. Integrative Neurophysiology PhD student Loos M. Molecular and Cellular Neurobiology PhD student Poorthuis R. Integrative Neurophysiology PhD student Rao P. Molecular and Cellular Neurobiology PhD student Silva G. Integrative Neurophysiology PhD student Verhoog M. Integrative Neurophysiology 3 ERC/VU 0,75 3 Synaptologics 0,45 3 ERC/VU 0,38 3 EU 0,37 3 ERC/VU 0,38 3 ERC/VU 0,75 Genes and the Brain: ADDICTIVE BEHAVIOR funding fte ititle Name Department Funding type Tenured Boomsma D.I. Biological Psychology 1 FPP 0,05 Tenured Drukarch B. Anatomy and 1 VUmc 0,10 Neurosciences Tenured Li K.W. Molecular and Cellular 1 FALW 0,04 Neurobiology Tenured Mansvelder H.D. Integrative 1 FALW 0,04 Neurophysiology Tenured Mulder A.B. Anatomy and 1 VUmc 0,20 Neurosciences Tenured Pattij T. Anatomy and 1 VUmc 0,40 Neurosciences Tenured Penninx B.W.J.H. Psychiatry 1 VUmc 0,10 Tenured Schoffelmeer A.N.M. Anatomy and 1 VUmc 0,50 Neurosciences Tenured Smit A.B. Molecular and Cellular 1 FALW 0,04 Neurobiology Tenured Spijker S. Molecular and Cellular 1 FALW 0,12 Neurobiology Tenured Veltman D.J. Psychiatry 1 VUmc 0,10 Tenured Voorn P. Anatomy and 1 VUmc 0,10 Neurosciences Tenured Vries T.J. de Anatomy and 1 VUmc 0,60 Neurosciences Tenured Vries T.J. de Molecular and Cellular 1 FALW 0,04 Neurobiology Tenured Vink J.M. Biological Psychology 2 NWO 0,60 Oever M.C. van den Molecular and Cellular Neurobiology Rotaru D.C. Integrative Neurophysiology Peters J.L. Anatomy and Neurosciences Diergaarde L. Anatomy and Neurosciences PhD student Lubbers B.R. Molecular and Cellular Neurobiology PhD student Prins M. Anatomy and Neurosciences PhD student Boersma N. Anatomy and Neurosciences PhD student Gao P. Anatomy and Neurosciences PhD student Goriounova N.A. Integrative Neurophysiology PhD student Riga D. Molecular and Cellular Neurobiology PhD student Schippers M.C. Anatomy and Neurosciences 1 FALW 0,90 1 FALW 0,45 2 NWO 0,20 4 0,50 1 FALW 0,75 1 VUmc 0,00 2 NWO 0,75 2 NWO 0,75 2 NWO 0,37 2 FALW 0,75 2 ZonMW 0,69 67

70 PhD student Sjoerds Z. Psychiatry 2 ZonMW 0,80 PhD student Wouda J.A. Molecular and Cellular Neurobiology PhD student Poorthuis R. Integrative Neurophysiology PhD student Silva G. Integrative Neurophysiology PhD student Wiskerke J. Anatomy and Neurosciences 2 FALW 0,75 3 ERC/VU 0,37 3 ERC/VU 0,37 4 0,75 Genes and the Brain: SYSTEMS BIOLOGY OF THE SYNAPSE funding fte Title full name Department Funding type Tenured Groffen A.J.A. VUmc, KG, FGA 1 VUmc 0,40 Tenured Kesteren R.E. van Molecular and Cellular 1 FALW 0,24 Neurobiology Tenured Li K.W. Molecular and Cellular 1 FALW 0,28 Neurobiology Tenured Mansvelder H.D. Integrative 1 FALW 0,04 Neurophysiology Tenured Meredith R. Integrative 1 FALW 0,03 Neurophysiology Tenured Ooyen A. van Integrative 1 FALW 0,20 Neurophysiology Tenured Smit A.B. Molecular and Cellular 1 FALW 0,04 Neurobiology Tenured Spijker S. Molecular and Cellular 1 FALW 0,20 Neurobiology Tenured Toonen R.F.G. Functional Genomics 1 VU 0,40 Tenured Verhage M. Functional Genomics 1 VU/VUmc 0,05 Boiko T.S.S. Functional Genomics 1 VU 0,60 Klaassen R.V. Molecular and Cellular 1 FALW 0,90 Neurobiology Meredith R. Integrative 1 FALW 0,22 Neurophysiology Nierop P. van Molecular and Cellular 1 FALW 0,72 Neurobiology Rotaru D.C. Integrative 1 FALW 0,45 Neurophysiology Stiedl R.O. Functional Genomics 1 VU 0,40 Verheijen M.H.G. Molecular and Cellular 1 FALW 0,40 Neurobiology Wit H. de VUmc, KG, FGA 1 VUmc 0,40 Cornelisse L.N. VUmc KG, FALW FGA 2 0,90 Weber J.P. Functional Genomics 2 NWO 0,90 Guillem K. Integrative 3 ERC/VU 0,90 Neurophysiology Walter A.M. Functional Genomics 3 NIH/EMBO 0,90 PhD student Broeke J.H.P. Functional Genomics 1 VU 0,25 PhD student Farina M. Functional Genomics 1 VU 0,13 PhD student Jong A.P.H. de Functional Genomics 1 VU 0,75 PhD student King C.R. Functional Genomics 1 VU 0,75 PhD student Lips E.S. Functional Genomics 1 NCA 0,38 PhD student Loos M. Molecular and Cellular 1 FALW 0,15 Neurobiology PhD student Maroteaux G.P. Functional Genomics 1 VU 0,75 PhD student Meijer M. Functional Genomics 1 VU 0,75 PhD student Qureshi N.J. Molecular and Cellular 1 Univ of London 0,19 Neurobiology PhD student Youn J.U. Functional Genomics 1 VU 0,75 68

71 PhD student Bospoort R. van de Functional Genomics 2 NWO 0,75 PhD student Cijsouw A. Functional Genomics 2 NWO 0,75 PhD student Díez Arazola R. Functional Genomics 2 NWO 0,75 PhD student Farina M. Functional Genomics 2 ENC 0,12 PhD student Geerts C.J. Functional Genomics 2 CMSB 0,75 PhD student Giniatullina A. Functional Genomics 2 NWO 0,75 PhD student Goriounova N.A. Integrative 2 NWO 0,38 Neurophysiology PhD student Groen M. Integrative 2 NWO 0,37 Neurophysiology PhD student Lips E.S. Functional Genomics 2 NWO 0,37 PhD student Schmitz S. Functional Genomics 2 NWO 0,75 PhD student Schotten S. Functional Genomics 2 NWO 0,70 PhD student Bokhoven P. van Molecular and Cellular 3 TI Pharma 0,15 Neurobiology PhD student Chen N. Molecular and Cellular 3 NISB 0,75 Neurobiology PhD student Hager T. Functional Genomics 3 Synaptologics 0,75 PhD student Janssen K.B. Functional Genomics 3 EU-SYNSYS 0,15 PhD student Karataeva A.R. Molecular and Cellular 3 EU Eurospin 0,62 Neurobiology PhD student Klemmer P. Molecular and Cellular 3 EU 0,75 Neurobiology PhD student Kramvis I. Integrative 3 Synaptologics 0,25 Neurophysiology PhD student Kurps J. Functional Genomics 3 EU-BrainTrain 0,20 PhD student Lauks J. Functional Genomics 3 Marie Curie 0,75 PhD student Negrean A. Integrative Neurophysiology PhD student Pandya N.J. Molecular and Cellular Neurobiology PhD student Rao P. Molecular and Cellular Neurobiology PhD student Ruiperez M. Integrative Alonso Neurophysiology PhD student Vegh M.J. Molecular and Cellular Neurobiology 3 ERC/VU 0,38 3 EU Braintrain 0,31 3 EU 0,38 3 SynSys 0,62 3 TI Pharma 0,37 69

72 Brain Disease Mechanisms: ANXIETY & DEPRESSION funding fte Title full name Department Funding type Tenured Geus J.C.N. Biological Psychology 1 FPP 0,10 Tenured Heutink P. Clinical Genetics and 1 VUmc 0,20 Antropgenetics, Medical Genetics Tenured Hoogendijk W.J.G. Psychiatry 1 VUmc 0,50 Tenured Lammertsma A.A. Nuclear Medicine & 1 VUmc 0,05 PET Research Tenured Li K.W. Molecular and Cellular 1 FALW 0,04 Neurobiology Tenured Penninx B.W.J.H. Psychiatry 1 VUmc 0,10 Tenured Smit A.B. Molecular and Cellular 1 FALW 0,04 Neurobiology Tenured Smit J.H. Psychatrie 1 VUmc 0,10 Tenured Spijker S. Molecular and Cellular 1 FALW 0,04 Neurobiology Tenured Uylings H.B.M. Anatomy and 1 VUmc 0,20 Neurosciences Tenured Veltman D.J. Psychiatry 1 VUmc 0,20 Tenured Verhage M. Functional Genomics 1 VU/VUmc 0,05 Tenured Boomsma D.I. Biological Psychology 3 EU 0,05 Tenured Bochdanovits Z. Clinical Genetics and 4 TI Pharma 0,70 Antropgenetics, Medical Genetics Bet P.M. Clinical 1 VUmc 0,20 Pharmacology Heuvel O.A. van den Psychiatry 1 Vumc GGZ Psych 0,10 Rizzu P. Clinical Genetics and Antropgenetics, Medical Genetics 1 VUmc 0,10 Heuvel O.A. van den Psychiatry 2 NWO 0,10 Middeldorp C.M. Biological Psychology 2 NWO 0,30 Savyuk S Biological Psychology 3 EU 0,40 Sistermans N. Neurology 3 0,85 Sizoo E.M. Neurology 3 0,21 PhD student Klumpers U.M.H. Psychiatry 1 VUmc 0,10 PhD student Lamb D.J.A. Biological Psychology 1 FPP 0,70 PhD student Lieverse R. Psychiatry 1 VUmc 0,30 PhD student Braber A. den Biological Psychology 2 NWO 0,90 PhD student Nivard M. Biological Psychology 2 NWO 0,04 PhD student Vreeburg S.A. Psychiatry 2 ZonMW 0,10 PhD student Woudstra S.A. Psychiatry 2 0,80 PhD student Abdellaoui A. Biological Psychology 3 CMSB 0,45 PhD student Bokhoven P. van Molecular and Cellular 3 TI Pharma 0,60 Neurobiology PhD student Bakker I.M.C. Clinical Genetics and 4 TI Pharma 0,75 Antropgenetics, Medical Genetics PhD student Bevova M.R. Clinical Genetics and 4 TI Pharma 0,75 Antropgenetics, Medical Genetics PhD student Mill J.G. van Psychiatry 4 Servier 0,50 PhD student Verbeek E.C. Clinical Genetics and Antropgenetics, Medical Genetics 4 TI Pharma 0,75 70

73 Brain Disease Mechanisms: NEURODEGENERATION funding fte Title full name Department Funding type Tenured Barkhof F. Radiology 1 VUmc 0,20 Tenured Blankenstein M.A. Clinical Chemistry 1 VUmc 0,20 Tenured Groenewegen H.J. Anatomy and 1 VUmc 0,10 Neurosciences Tenured Heutink P. Clinical Genetics 1 VUmc 0,30 and Antropgenetics, Medical Genetics Tenured Hoogland P.V.J.M. Anatomy and 1 VUmc 0,10 Neurosciences Tenured Lammertsma A.A. Nuclear Medicine & 1 VUmc 0,20 PET Research Tenured Mansvelder H.D. Integrative 1 FALW 0,01 Neurophysiology Tenured Rozemuller J.M. Pathology 1 VUmc 0,20 Tenured Scheltens P. Neurology 1 VUmc 0,40 Tenured Smit A.B. Molecular and Cellular 1 FALW 0,04 Neurobiology Tenured Stam C.J. Neurology 1 VUmc 0,20 Tenured Vies S.M. van der Pathology 1 VUmc 0,40 Tenured Witter M.P. Anatomy and 1 VUmc 0,20 Neurosciences Tenured Berg W.D.J. van de Anatomy and 1 VUmc 0,70 Neurosciences Tenured Bochdanovits Z. Clinical Genetics 1 VUmc 0,20 and Antropgenetics, Medical Genetics Tenured Dam A.M.W. van Anatomy and 1 VUmc 0,20 Neurosciences Tenured Drukarch B. Anatomy and 1 VUmc 0,50 Neurosciences Tenured Flier W.M. van der Neurology 1 VUmc 0,70 Tenured Flier W.M. van der Neurology 3 0,30 Tenured Heuvel O.A. van den Anatomy and 1 VUmc 0,20 Neurosciences Tenured Kesteren R.E. van Molecular and Cellular 1 FALW 0,16 Neurobiology Tenured Li K.W. Molecular and Cellular 1 FALW 0,04 Neurobiology Tenured Teunissen C.E. Clinical Chemistry 1 VUmc 0,20 Tenured Voorn P. Anatomy and 1 VUmc 0,50 Neurosciences Tenured Werf Y.D. van der Anatomy and 1 VUmc 0,30 Neurosciences Tenured Wilhelmus M.M.M. Anatomy and 1 VUmc 0,65 Neurosciences Tenured Wouterlood F.G. Anatomy and 1 VUmc 0,60 Neurosciences Beek J.H.G.M. van Clinical Genetics 1 VUmc 1,00 and Antropgenetics, Medical Genetics Berckel B.N.M. van Nuclear Medicine & 1 VUmc 0,30 PET Research Berendse H.W. Neurology 1 VUmc 0,30 Comans E.F.I. Nuclear Medicine & 1 VUmc 0,30 PET Research Dijk K.D. van Anatomy and 1 VUmc 0,65 Neurosciences Foncke E.M.J. Neurology 1 VUmc 0,20 Foncke E.M.J. Neurology 1 VUmc 0,10 Haan W. de Neurology 1 VUmc 0,43 71

74 Kamphorst W. Pathology 1 VUmc 0,00 Pardo L.M. Clinical Genetics and Antropgenetics, Medical Genetics 1 VUmc 0,50 Pijnenburg Y.A.L. Neurology 1 VUmc 0,30 Rizzu P. Clinical Genetics and Antropgenetics, Medical Genetics 1 VUmc 0,30 Visser M.C. Neurology 1 VUmc 0,10 Assema D.M.E. van Neurology 2 0,42 Hoozemans J.J.M. Pathology 2 NWO 0,40 Rossum I.A. van Neurology 2 0,85 Visser P.J. Neurology 2 0,30 Assema D.M.E. van Neurology 3 0,43 Goos J.D.C. Neurology 3 0,85 Groot M. de Neurology 3 0,28 Haan W. de Neurology 3 0,35 Harten A.C. van Neurology 3 0,85 Jain S. Clinical Genetics and Antropgenetics, Medical Genetics 3 0,50 Jongbloed W. Clinical Chemistry 3 CTTM 0,75 Kester M.I. Neurology 3 Alz C 0,28 Koedam E.L.G.E. Neurology 3 Alz C 0,50 Lemstra A.W. Neurology 3 0,38 Mulder S.D. Clinical Chemistry 3 Alz C 0,75 Olde Dubbelink K.T.E. Neurology 3 Int. Parkinson 0,75 Found Prins N.D. Neurology 3 0,80 Rezaei H. Neurology 3 0,89 Sikkes S.A.M. Epidemiology and Biostatistics 3 Alz C/KEB 0,75 Simon-Sanchez J. Clinical Genetics 3 Hersenbank 1,00 and Antropgenetics, Medical Genetics Smits L.L. Neurology 3 VUmc/PSI 1,00 Vrenken H. Physics and Medical Technology PhD student Francescatto M. Clinical Genetics and Antropgenetics, Medical Genetics Staekenborg S.S. Neurology 3 0,90 Tolboom N. Neurology 3 0,50 Veerhuis R. Clinical Chemistry 3 0,70 Verwey N.A. Neurology 3 0,70 PhD student Jager A.M. de Anatomy and Neurosciences PhD student Kallen L.R. van der Molecular and Cellular Neurobiology PhD student Prins M. Anatomy and Neurosciences PhD student Cornelis J. Molecular and Cellular Neurobiology 3 Alz C 0,50 1 VUmc 0,75 1 VUmc 0,06 1 FALW 0,75 1 VUmc 0,00 2 Innov. treatment for neurotrauma 0,75 72

75 PhD student Duray B.N. Anatomy and 2 0,20 Neurosciences PhD student Idriss I. Pathology 2 ESF via NWO 0,75 PhD student Möller C. Neurology 2 Nat. Initiatief 0,25 Hersenen en Cognitie PhD student Verhoef K.M.W. Anatomy and 2 0,10 Neurosciences PhD student Abel D. van Clinical Chemistry 3 0,75 PhD student Adriaanse S.F. Nuclear Medicine & 3 0,19 PET Research PhD student Blaas E. Molecular and Cellular 3 TI Pharma 0,75 Neurobiology PhD student Carrano A. Pathology 3 0,75 PhD student Dijkstra A.A. Anatomy and 3 PBF 0,75 Neurosciences PhD student Doef T.F. van der Nuclear Medicine & 3 0,38 PET Research PhD student Espitia Pinzón N.E. Anatomy and 3 0,06 Neurosciences PhD student Heetveld S. Clinical Genetics 3 0,75 and Antropgenetics, Medical Genetics PhD student Ossenkoppele R. Neurology 3 1,00 PhD student Supandi F.B. Clinical Genetics 3 0,75 and Antropgenetics, Medical Genetics PhD student Vegh M.J. Molecular and Cellular 3 TI Pharma 0,38 Neurobiology PhD student Verhaar R. Anatomy and 3 0,75 Neurosciences PhD student Verhave N Molecular and Cellular 3 FALW 0,16 Neurobiology PhD student Waal H. de Neurology 3 0,85 Brain Disease Mechanisms: WHITE MATTER DISEASE funding fte Title full name Department Funding type Tenured Dam A.M.W. van Anatomy and 1 VUmc 0,60 Neurosciences Tenured Pouwels P.J.W. Physics and Medical 1 VUmc 0,30 Technology Tenured Scheper G.C. Neurology Children 1 VUmc 0,80 Tenured Geurts J.J.G. Pathology 3 SMSR 0,20 Tenured Horssen J. van Molecular Cell 3 SMSR 0,50 Biology Tenured Teunissen C.E. Clinical Chemistry 3 SMSR 0,50 Tenured Amor S. Pathology 1 VUmc 0,60 Tenured Drukarch B. Anatomy and 1 VUmc 0,10 Neurosciences Tenured Geurts J.J.G. Anatomy and 1 VUmc 0,10 Neurosciences Tenured Vries H.E. de Molecular Cell 1 VUmc 0,60 Biology Tenured Barkhof F. Radiology 1 VUmc 0,40 Tenured Castelijns J.A. Radiology 1 VUmc 0,20 Tenured Dijkstra C.D. Molecular Cell 1 VUmc 0,40 Biology Tenured Elsen P.J. van den Pathology 1 VUmc 0,10 Tenured Jakobs C.A.J.M. Clinical Chemistry 1 VUmc 0,20 Tenured Knaap M.S. van der Neurology Children 1 VUmc 0,60 Tenured Kooijk Y. van Molecular Cell Biology Tenured Mansvelder H.D. Integrative Neurophysiology 1 VUmc 0,10 1 FALW 0,10 73

76 Tenured Polman C.H. Neurology 1 VUmc 0,40 Tenured Uitdehaag B.M.J. Epidemiology and 1 VUmc 0,30 Biostatistics Tenured Uitdehaag B.M.J. Neurology 1 VUmc 0,10 Tenured Valk P. van der Pathology 1 VUmc 0,20 Tenured Verhage M. Clinical Genetics and 1 VUmc 0,05 Antropgenetics, Functional Genomics Tenured Verweij C.L. Pathology 1 VUmc 0,10 Amor S. Pathology 1 VUmc 0,20 Boor P.K.I. Neurology Children 1 VUmc 1,00 Brink H.J. ten Clinical Chemistry 1 VUmc 0,15 Graaf W.L. de Radiology 1 VUmc 0,38 Hoetjes N.J. Nuclear Medicine & PET Research 1 VUmc 0,20 Kamp J.M. van de Clinical Genetics and 1 VUmc 0,20 Antropgenetics Killestein J. Neurology 1 VUmc 0,40 Linden F.A.H. van der Epidemiology and 1 VUmc 0,60 Biostatistics Oosten B.W. van Neurology 1 VUmc 0,20 Oostrom K.J. Medical Psychology 1 VUmc 0,10 Salomons G.S. Clinical Chemistry 1 VUmc 0,40 Struijs E.A. Clinical Chemistry 1 VUmc 0,60 Vereyken E.J.F. Molecular Cell 1 VUmc 0,17 Biology Vermeulen R.J. Neurology Children 1 VUmc 0,20 Voorn J.P. van der Pathology 1 VUmc 0,20 Vrenken H. Physics and Medical 1 VUmc 0,50 Technology Wamelink M.M.C. Clinical Chemistry 1 VUmc 0,20 Wolf N.I. Neurology Children 1 VUmc 0,30 Killestein J. Neurology 2 EEC 0,40 Kooij G. Molecular Cell Biology 2 1,00 Reijerkerk A. Molecular Cell 2 NWO/TIP 1,00 Biology Balk L.J. Neurology 3 0,38 Graaf W.L. de Radiology 3 SMSR 0,37 Horssen J. van Molecular Cell 3 SMSR 0,50 Biology Kilsdonk I.D. Radiology 3 0,56 Nielsen J.M. Neurology 3 funds 0,10 Sombekke M.H. Neurology 3 funds 0,38 Sonder J.M. Epidemiology and 3 funds 1,00 Biostatistics Tewarie P.W. Neurology 3 0,15 Wiebenga O.T. Radiology / ANW 3 0,69 Bosma L.V.A.E. Neurology 4 funds 0,10 Petzold A.F.S. Neurology 4 industry 0,20 Seewann A.M. Neurology 4 industry 0,75 74

77 Sombekke M.H. Neurology 4 funds 0,37 Vennegoor A. Neurology 4 funds 0,25 PhD student Kranendijk M. Clinical Chemistry 1 VUmc 0,75 PhD student Ndika J.D.T. Clinical Chemistry 1 VUmc 0,75 PhD student Prins M. Anatomy and 1 VUmc 0,70 Neurosciences PhD student Vereyken E.J.F. Molecular Cell 1 VUmc 0,63 Biology PhD student Betsalel O.T. Clinical Chemistry 2 ZonMW 0,75 PhD student Ridder M.C. Neurology Children 2 ZonMW 0,75 PhD student Steenweg M.E. Neurology Children 2 ZonMW 0,75 PhD student Berge L. van Neurology Children 3 funds 0,75 PhD student Camargo N.K. Molecular and Cellular 3 EU 0,72 Neurobiology PhD student Doorn R.P. van Molecular Cell 3 SMSR 0,75 Biology PhD student Espitia Pinzón N.E. Anatomy and 3 0,10 Neurosciences PhD student Geytenbeek J.J.M. Rehabilitation 3 funds 0,40 Medicine PhD student Goudriaan A Molecular and Cellular 3 Danone 0,75 Neurobiology PhD student Hulst H.E. Radiology / ANW 3 SMSR 0,75 PhD student Kooi E.J. Pathology /ANW 3 SMSR 0,75 PhD student Lei H.D.W. van der Neurology Children 3 funds 0,50 PhD student Lopez Pinheiro M.A. Molecular Cell 3 MS Center Program 0,13 Biology Grant PhD student Lopez Soriano A. Anatomy and 3 0,13 Neurosciences PhD student Mizee M.R. Molecular Cell 3 SMSR 0,75 Biology PhD student Nijland P.G. Pathology 3 MS Center Program 0,19 Grant PhD student Schoonheim M.M. Radiology / ANW 3 SMSR 0,52 PhD student Singh S. Pathology 3 0,20 PhD student Star B.J. van der Pathology 3 0,69 PhD student Steenwijk M.D. Radiology 3 0,19 PhD student Strijbis E.M.M. Neurology / ANW 3 funds 0,38 PhD student Vigeveno R.M. Radiology / ANW 3 0,25 PhD student Vogel D.Y.S. Molecular Cell 3 MS Center Program 0,13 Biology Grant PhD student Voort L.F. van der Neurology 3 funds 0,10 PhD student Witte M.E. Pathology 3 SMSR 0,75 PhD student Popescu V. Radiology 4 industry 0,25 PhD student Strijbis E.M.M. Neurology 4 industry 0,37 75

78 Affiliated research funding fte Title full name Department Funding type Tenured Bakker J. VICI, University Luik, 1 VUmc 0,20 België Tenured Blankenstein M.A. Clinical Chemistry 1 VUmc 0,10 Tenured Cohen- P.T. Medical Psychology 1 VUmc 0,20 Kettenis Tenured Huisman J. Medical Psychology 1 VUmc 0,20 Tenured Trotsenburg M.A.A. van Gynaecology 1 VUmc 0,20 Bie H.M.A. de Pediatrics 4 0,80 Drent M.L. Endocrinology 1 VUmc 0,20 Heijboer A.C. Clinical Chemistry 1 VUmc 0,10 Hompes P.G.A. Reproductive 1 VUmc 0,20 medicine Jeltes J. Medical Psychology 4 0,44 König T.E. Reproductive 4 0,75 medicine Kreukels B.P.C. Medical Psychology 1 VUmc 0,80 Kuijper E.A.M. Obstetrics and 4 0,20 Gynaecology Lambalk C.B. Reproductive 1 VUmc 0,30 medicine Nieuwpoort I.C. van Endocrinology 3 0,75 Oostrom K.J. Medical Psychology 1 VUmc 0,10 Ronde W. de Endocrinology 1 VUmc 0,20 Rotteveel J. Pediatrics 1 VUmc 0,20 Steensma T.D. Medical Psychology 3 0,20 Vries A.L.C. de GGZin Geest 1 VUmc 0,30 Psychiatry Weissenbruch M.M. van Neonatology 1 VUmc 0,20 PhD student Bui H.N. Clinical Chemistry 1 VUmc 0,75 PhD student Soleman R.S. Medical Psychology 1 VUmc 0,50 PhD student Burke S.M. Medical Psychology 2 NWO 1,00 PhD student Bunderen C.C. van Endocrinology 3 0,75 PhD student Soleman R.S. Medical Psychology 3 0,50 PhD student Hendriks M.L. Verloskunde en 4 0,20 Gynaecologie PhD student Schagen S.E.E. Pediatrics 4 0,75 76

79 Appendix 2: Newly started PhD projects 2010 PhD student Investigator Department Project Program Aarts, E. Sluis, S. van der; Verhage, M. Functional genomics Analysis of complex genotypephenotype relations in mice Integrative Analysis & Modeling Abdelloui, A. Boomsma, D.I.; Biological Psychiatric Genetics Anxiety & Depression Penninx, B. Psychology Adriaanse, S. Berckel, B.N.M. van Nucl ear Resting state fmri en amyloid Medicine imaging met PET bij de ziekte van Alzheimer Chavarria-Siles, I. Posthuma, D. Functional genomics Imaging Genetics of Intelligence Integrative Analysis & Modeling Dhingra, A. Heutink, P. Clinical Genetics, Medical Genetics Doorn, K. Dam, A.M.W. van; Lucassen, P.J. (SILS) Anatomy & Neurosciences Duray, B.N. Voorn, P. Anatomy & Neurosciences Espitia Pinzon, N Dam, A.M.W. van; Baron, W. Anatomy & Neurosciences Farina, M. Toonen, R.F.G. Functional genomics Gerrits, N. Jager, M. de Werf, Y.D. van der; Heuvel, O.A. van den; Veltman, D.J.; Groenewegen, H.J. Wilhelmus, M.M.M.; Drukarch, B. NCA Anatomy & Neurosciences Anatomy & Neurosciences Janssen, K.B. Groffen, A.J.A. Functional genomics Jongbloed, W. Veerhuis, R. Clinical Chemistry Karataeva, A. Smit, A.B. Molecular and Cellular Neurobiology King, C. Toonen, R.F.G. Functional genomics Kramvis, I. Meredith, R.M. Integrative Neurophysiology Kurps, J. Wit, H. de Functional genomics Lopes Pinheiro, M. Möller, C. Nijland, P. Nivard, M. Reijerkerk A.; Vries H.E. de Flier, W.M. van der; Vrenken, H. Horssen, J. van; Vries, H.E. de Boomsma, D.I.,; Middeldorp, C.M. Molecular Cell Biology and Immunology Neurology Molecular Cell Biology and Immunology Biological Psychology Nieuwe therapeutische mogelijkheden voor de ziekte van Parkinosn door gennetwerkanalyse Understanding selective vulnerability in Parkinson's disease; does a regional-specific microglial expression profile determine stem cell responsivity, resistance to pathology or loss? Disturbed neural synchrony in an animal model of Parkinson s disease. Tissue Transglutaminase in astrogliosis and oligodendrocyte differentiation: towards improved remyelination Live at the membrane - identifying molecular mechanisms that transport and fuse secretory vesicles in neurons Cortico-cortical and corticosubcortical connectivity in Parkinson s disease The role of tissue transglutaminase in the pathogenesis of cerebral amyloid angiopathy. Tomosyn CTMM LeARN Identification of interactors of the Shisa family of potential AMPA receptor modulatory proteins Strength by numbers: local protein accumulation controls presynaptic output in health and disease Inhibitory signalling in the manifestation of behavioural and cognitive anomalics in fragile-x syndrome Characterization of Munc18-1 mediated regulation of cortical F-actin in neurosecretion (BrainTrain project) MS Center program grant Nationaal Initiatief Hersenen en Cognitie: Functionele markers voor cognitieve stoornissen MS Center Program grant Genetic influences on stability and change in psychopathology from childhood to your adulthood White Matter Disease Systems Biology of the Synapse Brain Imaging Systems Biology of the Synapse Systems Biology of the Synapse Systems Biology of the Synapse Attention & Cognition Systems Biology of the Synapse White Matter Disease White Matter Disease Anxiety & Depression 77

80 Pandya, N. Smit, A.B. Molecular and Cellular Neurobiology Prins, M. Dam, A.M.W. van; Vries, T.J. de; Vries, H.E.de Anatomy & Neurosciences Qureshi, N. Smit, A.B. Molecular and Cellular Neurobiology Ros, B. Gunst, M.C.M. de Mathematics, FEW Ruiperez, M. Mansvelder, H.D> Integrative Neurophysiology Schippers, M.C. Schoffelmeer, A.N.M. Anatomy & Neurosciences Structural and Functional studies of Novel of Glutamate receptor interacting proteins Do glia-derived factors determine hippocampal neuronal fate in pathogenetically differing brain disorders? Proteomics and molecular genetics of glycine receptor interacting proteins in startle disease/hyperekplexia Modeling brain network dynamics The effect of AMPA-modulator proteins on brain oscillations and on synaptic currents of the hippocampus Deep brain stimulation in chronic refractory drug dependence: a translational study (ZonMw) Dynamic modelling of presynaptic gene networks Systems Biology of the Synapse White Matter Disease Addictive Behavior Systems Biology of the Synapse Integrative Analysis & Modeling Systems Biology of the Synapse Addictive Behavior Schotten, B. Cornelisse, L.N. Functional genomics Integrative Analysis & Modeling Singh, S. Amor, S. Pathology Natural control of inflammation White Matter Disease in preactive MS Lesions Steenwijk, M.D. Vrenken, H.; Pouwels, Radiology MS Center Program Grant WP 3a White Matter Disease P.J.W. Stroeder, J. Mansvelder, H.D. Integrative Physiological analysis of AMPARmodulating Systems Biology of the Neurophysiology proteins of the Shisa Synapse family Struik, R. Vries, T.J. de; Peters, J.; Smit, A.B.t Molecular and Cellular Neurobiology Vogel, D. Amor, S.; Dijkstra, C.D. Pathology / MCBI Vries, F. de Veltman, D.J.; Balkom, A.J.L.M. van; Cath, D.C.; Heuvel, O.A. van den Zeeuw, L.J. de Boomsma, D.I.; Geus, J.C.N de TOP grant: An integrative neurobiological approach to identify and validate synaptic targets for the treatment of drug addiction Microglia and neuronal interations in vitro models of MS Addictive Behavior White Matter Disease Psychiatry Imaging bij GTS en OCD Brain Imaging Anxiety & Depression Biological Psychology Zijlstra, S. Heutink, P. Clinical Genetics, Medical Genetics Twin-family study of individual differences in school achievement PBF Wetenschapsprijs 2009 Attention & Cognition 78

81 Appendix 3: Scientific output Advanced Technology Programs: BRAIN IMAGING Theses VU/VUmc PhD-student at VU (A) Altena, E. (2010, maart 17). Mapping insomnia: brain structure, functon and sleep intervention. VU Vrije Universiteit. Prom./coprom.: prof. dr. E.J. van Someren, prof. dr. D.F. Swaab, dr. Y.D. van der Werf & prof. dr. P. Scheltens. Scientific papers refereed Altena, E., Ramautar, J.R., Werf, Y.D. van der & Someren, E.J.W. van (2010). Do sleep complaints contribute to age-related cognitive decline? Progress in Brain Research, 185, Altena, E., Vrenken, H., Werf, Y.D. van der, Heuvel, O.A. van den & Someren, E.J.W. van (2010). Reduced Orbitofrontal and Parietal Gray Matter in Chronic Insomnia: A Voxel-Based Morphometric Study. Biological Psychiatry, 67(2), Beukers, R.J., Foncke, E.M.J., Meer, J.N. van der, Nederveen, A.J., Ruiter, M.B. de, Bour, L.J., Veltman, D.J. & Tijssen, M.A.J. (2010). Disorganized Sensorimotor Integration in Mutation- Positive Myoclonus-Dystonia A Functional Magnetic Resonance Imaging Study. Archives of Neurology, 67(4), Bianchi, L., Sami, S., Hillebrand, A., Fawcett, I.P., Quitadamo, L.R. & Seri, S. (2010). Which Physiological Components are More Suitable for Visual ERP Based Brain-Computer Interface? A Preliminary MEG/EEG Study. Brain Topography, 23(2), Bie, H.M.A. de, Boersma, M., Wattjes, M.P., Adriaanse, S., Vermeulen, R.J., Oostrom, K.J., Huisman, J., Veltman, D.J. & Delemarre-van de Waal, H.A. (2010). Preparing children with a mock scanner training protocol results in high quality structural and functional MRI scans. European Journal of Pediatrics, 169(9), Bokkers, R.P.H., Bremmer, J.P., Berckel, B.N.M. van, Lammertsma, A.A., Hendrikse, J., Pluim, J.P.W., Kappelle, L.J., Boellaard, R. & Klijn, C.J.M. (2010). Arterial spin labeling perfusion MRI at multiple delay times: a correlative study with (H2O)-O-15 positron emission tomography in patients with symptomatic carotid artery occlusion. Journal of Cerebral Blood Flow and Metabolism, 30(1), Braber, A. den, Ent, D. van t, Cath, D.C., Wagner, J., Boomsma, D.I. & Geus, E.J.C. de (2010). Brain activation during cognitive planning in twins discordant or concordant for obsessive compulsive symptoms. Brain, 133(10), Brouwer, R.M., Mandl, R.C.W., Peper, J.S., Baal, G.C.M. van, Kahn, R.S., Boomsma, D.I. & Hulshoff Pol, H.E. (2010). Heritability of DTI and MTR in nine-year-old children. Neuroimage, 53(3), Calmels, C., Hars, M., Jarry, G. & Stam, C.J. (2010). Non-linear EEG synchronization during observation: Effects of instructions and expertise. Psychophysiology, 47(5), Colon, A.J., Hofman, P, Ossenblok, P.P.W., Jansen, J.F.A., Beek, L.C. ter, Berting, R., Stam, C.J. & Boon, P. (2010). MRS-lateralisation index in patients with epilepsy and focal cortical dysplasia or a MEG-focus using bilateral single voxels. Epilepsy Research, 89(1), Cremers, H.R., Demenescu, L.R., Aleman, A., Renken, R., Tol, M.J. van, Wee, N.J.A. van der, Veltman, D.J. & Roelofs, K. (2010). Neuroticism modulates amygdala-prefrontal connectivity in response to negative emotional facial expressions. Neuroimage, 49(1), Dijk, J.G. van, Stam, C.J., Zwarts, M.J., Mess, W. & Putten, M.J.A.M. van (2010). De terminologie van het EEG: het is tijd om scherper te worden. Tijdschrift voor Neurologie & Neurochirurgie, 111(1), Douw, L., Dellen, E. van, Baayen, C., Klein, M., Velis, D.N., Alpherts, W.C.J., Heimans, J.J., Reijneveld, J.C. & Stam, C.J. (2010). The lesioned brain: still a small-world? Frontiers in Human Neuroscience, 4, 174. Ent, D. van 't, Soelen, I.L.C. van, Stam, K.J., Geus, E.J.C. de & Boomsma, D.I. (2010). Genetic influence demonstrated for MEG-recorded somatosensory evoked responses. Psychophysiology, 47, Gaal, Z.A., Boha, R., Stam, C.J. & Mark, M. (2010). Age-dependent features of EEG-reactivity- Spectral, complexity, and network characteristics. Neuroscience Letters, 479(1),

82 Glatard, T., Soleman, R.S., Veltman, D.J., Nederveen, A.J. & Olabarriaga, S.D. (2010). Large-scale functional MRI study on a production grid. Future Generation Computer Systems, 26(4), Goudriaan, A.E., Ruiter, M.B. de, Brink, W. van den, Oosterlaan, J. & Veltman, D.J. (2010). Brain activation patterns associated with cue reactivity and craving in abstinent problem gamblers, heavy smokers and healthy controls: an fmri study. Addiction Biology, 15(4), Hall, S.D., Barnes, G.R., Furlong, P.L., Seri, S. & Hillebrand, A. (2010). Neuronal Network Pharmacodynamics of GABAergic Modulation in the Human Cortex Determined Using Pharmaco-Magnetoencephalography. Human Brain Mapping, 31(4), Harmelen, A.L. van, Tol, M.J. van, Wee, N.J.A. van der, Veltman, D.J., Aleman, A., Spinhoven, P., Buchem, M.A. van, Zitman, F.G., Penninx, B.W.J.H. & Elzinga, B.M. (2010). Reduced Medial Prefrontal Cortex Volume in Adults Reporting Childhood Emotional Maltreatment. Biological Psychiatry, 68(9), Heuvel, M.P., Mandl, R.C.W., Stam, C.J., Kahn, R.S. & Pol, H.E.H. (2010). Aberrant Frontal and Temporal Complex Network Structure in Schizophrenia: A Graph Theoretical Analysis. Journal of Neuroscience, 30(47), Heuvel, O.A. van den, Werf, Y.D. van der, Verhoef, K.M.W., Wit, S. de, Berendse, H.W., Wolters, E.C., Veltman, D.J. & Groenewegen, H.J. (2010). Frontal-striatal abnormalities underlying behaviours in the compulsive-impulsive spectrum. Journal of the Neurological Sciences, 289(1-2), Houdt, P.J. van, Munck, J.C. de, Zijlmans, M., Huiskamp, G., Leijten, F.S.S., Boon, P.A.J.M. & Ossenblok, P.P.W. (2010). Comparison of analytical strategies for EEG-correlated fmri data in patients with epilepsy. Magnetic Resonance Imaging, 28(8), Houdt, P.J. van, Ossenblok, P.P.W., Boon, P.A.J.M., Leijten, F.S.S., Velis, D.N., Stam, C.J. & Munck, J.C. de (2010). Correction For Pulse Height Variability Reduces Physiological Noise in Functional MRI When Studying Spontaneous Brain Activity. Human Brain Mapping, 31(2), Huyser, C., Veltman, D.J., Wolters, L.H., Haan, E. & Boer, F. (2010). Functional Magnetic Resonance Imaging During Planning Before and After Cognitive-Behavioral Therapy in Pediatric Obsessive-Compulsive Disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 49(12), Klerk, O.L. de, Willemsen, A.T.M., Bosker, F.J., Bartels, A.L., Hendrikse, N.H., Boer, J.A. den & Dierckx, R.A. (2010). Regional increase in P-glycoprotein function in the blood-brain barrier of patients with chronic schizophrenia: A PET study with [C-11]verapamil as a probe for P- glycoprotein function. Psychiatry Research. Neuroimaging, 183(2), Klumpers, U.M.H., Veltman, D.J., Drent, M.L., Boellaard, R., Comans, E.F.I., Meynen, G., Lammertsma, A.A. & Hoogendijk, W.J.G. (2010). Reduced parahippocampal and lateral temporal GABA(A)-[C-11]flumazenil binding in major depression: preliminary results. European Journal of Nuclear Medicine and Molecular Imaging, 37(3), Luurtsema, G., Verbeek, J., Lubberink, J.M., Lammertsma, A.A., Dierckx, R., Elsinga, P., Windhorst, A.D. & Waarde, A. van (2010). Carbon-11 Labeled Tracers for In Vivo Imaging of P- Glycoprotein Function: Kinetics, Advantages and Disadvantages. Current Topics in Medicinal Chemistry, 10(17), Luurtsema, G., Boellaard, R., Greuter, HN, Rijbroek, A., Takkenkamp, K., Geest, F.G.M. de, Buijs, F.L., Hendrikse, N.H., Franssen, E.J.F., Lingen, A. van & Lammertsma, A.A. (2010). Pharmaceutical preparation of oxygen-15 labelled molecular oxygen and carbon monoxide gasses in a hospital setting. Journal of Clinical Pharmacy and Therapeutics, 35(1), Mourik, J.E.M., Lubberink, J.M., Velden, F.H.P. van, Kloet, R.W., Berckel, B.N.M. van, Lammertsma, A.A. & Boellaard, R. (2010). In vivo validation of reconstruction-based resolution recovery for human brain studies. Journal of Cerebral Blood Flow and Metabolism, 30(2), Munck, J.C. de & Bijma, F. (2010). How are evoked responses generated? The need for a unified mathematical framework. Clinical Neurophysiology, 121(2), Ponten, S.C., Ronner, H.E., Strijers, R.L.M., Visser, M.C., Peerdeman, S.M., Vandertop, W.P., Beishuizen, A., Girbes, A.R.J. & Stam, C.J. (2010). Feasibility of online seizure detection with continuous EEG in the intensive care unit. Seizure - European Journal of Epilepsy, 19(9), Ponten, S.C., Daffertshofer, A., Hillebrand, A. & Stam, C.J. (2010). The relationship between structural and functional connectivity: graph theoretical analysis of an EEG neural mass model. Neuroimage, 52(3),

83 Smit, D.J.A., Luciano, M., Bartels, M., Beijsterveldt, C.E.M. van, Wright, M.J., Hansell, N., Brunner, H.G., Estourgie - van Burk, G.F., Geus, E.J.C. de, Martin, N.G. & Boomsma, D.I. (2010). Heritability of head size in Dutch and Australian twin families at ages 0 50 years. Twin Research and Human Genetics, 13(4), Stam, C.J. (2010). Characterization of anatomical and functional connectivity in the brain: A complex networks perspective. International Journal of Psychophysiology, 77(3), Stam, C.J., Hillebrand, A., Wang, H. & Mieghem, P. Van (2010). Emergence of modular structure in a large-scale brain network with interactions between dynamics and connectivity. Frontiers in Computational Neuroscience, 4, 133. Thomaes, K., Dorrepaal, E., Draijer, P.J., Ruiter, M.B. de, Balkom, A.J.L.M. van, Smit, J.H. & Veltman, D.J. (2010). Reduced anterior cingulate and orbitofrontal volumes in child abuse-related complex PTSD. Journal of Clinical Psychiatry, 71(12), Tol, M.J. van, Wee, N.J.A. van der, Heuvel, O.A. van den, Nielen, M.M.A., Demenescu, L.R., Aleman, A., Renken, R., Buchem, M.A. van, Zitman, F.G. & Veltman, D.J. (2010). Regional Brain Volume in Depression and Anxiety Disorders. Archives of General Psychiatry, 67(10), Veer, I.M., Beckmann, C.F., Tol, M.J. van, Ferrarini, L., Milles, J., Veltman, D.J., Aleman, A., Buchem, M.A. van, Wee, N.J. van der & Rombouts, S.A.R.B. (2010). Whole brain resting-state analysis reveals decreased functional connectivity in major depression. Frontiers in Systems Neuroscience, 4. Veltman, D.J., Ruhe, H.G. & Booij, J. (2010). Investigating Serotonergic Function Using Positron Emission Tomography: Overview and Recent Findings. Current Pharmaceutical Design, 16(18), Werf, Y.D. van der, Altena, E., Dijk, K.D. van, Strijers, R.L.M., Ruke, W. De, Stam, C.J. & Someren, E.J.W. van (2010). Is Disturbed Intracortical Excitability a Stable Trait of Chronic Insomnia? A Study Using Transcranial Magnetic Stimulation Before and After Multimodal Sleep Therapy. Biological Psychiatry, 68(10), Werf, Y.D. van der, Sanz-Arigita, E.J., Menning, S. & Heuvel, O.A. van den (2010). Modulating spontaneous brain activity using repetitive transcranial magnetic stimulation. BMC Neuroscience, 11. Wijk, B.C.M. van, Stam, C.J. & Daffertshofer, A. (2010). Comparing brain networks of different size and connectivity density using graph theory. PLoS ONE, 5(10), e Willemse, R.B., Munck, J.C. de, Verbunt, J.P.A., Ent, D. van 't, Ris, P., Baayen, J.C., Stam, C.J. & Vandertop, W.P. (2010). Topographical organization of Mu and Beta band activity associated with hand and foot movements in patients with perirolandic lesions. Open Neuroimaging Journal, 4, Yaqub, M.M., Tolboom, N., Berckel, B.N.M. van, Scheltens, P., Lammertsma, A.A. & Boellaard, R. (2010). Simplified parametric methods for [F-18]FDDNP studies. Neuroimage, 49(1), Scientific papers non-refereed Holst, R.J. van, Brink, W. van den, Veltman, D.J. & Goudriaan, A.E. (2010). Brain imaging studies in pathological gambling. Current Psychiatry Reports, 12(5), Scientific publications (books, monographs, book chapters, proceedings) Book/monograhps Stam, K., Douw, L. & Haan, W. de (2010). Hersenweb; wat moderne netwerktheorie ons leert over de werking van de hersenen. Amsterdam: Uitgeverij Bert Bakker. Book Chapter Leysen, J.E., Langlois, X., Heylen, L. & Lammertsma, A.A. (2010). Receptors: binding assays. In I.P. Stolermann (Ed.), Encyclopedia of Psychopharmacology (pp ). Berlin: Springer- Verlag. Munck, J.C. de, Gonçalves, S.I., Houdt, P.J. van, Ossenblok, P.P.W. & Silva, F.H. Lopes da (2010). Estimating the hemodynamic response of EEG-features, chapter in Simultaneous EEG and fmri: recording, analysis and application. In M. Ullsperger & S. Debener (Eds.), (pp ). Oxford: Oxford University Press. 81

84 Wilton, C., Hillebrand, A. & Henning, G.B. (2010). Spatiotemporal characteristics of cortical responses to a new dichotic pitch stimulus. In E.A. Lopez-Poveda, A.R. Palmer & R. Meddis (Eds.), The neurophysiological bases of auditory perception (pp ). New York: Springer. Professional publications Leijten, F., Debets, R. & Comans, E.F.I. (2010). SPECT en PET: de radioactieve bijdrage aan epilepsie diagnostiek. Epilepsie, 8(3), Advanced Technology Programs: DRUGS SCREENING & THERAPY DESIGN Theses external PhD-student at VU (B) Joosen, M.J.A. (2010, oktober 06). Towards improved models for treatment of organophosphate poisoning. VU Vrije Universiteit (129 pag.). Prom./coprom.: prof. dr. A.B. Smit & dr. H.H.P.M. van Helden. Advanced Technology Programs: INTEGRATIVE ANALYSIS & MODELING Theses VU/VUmc PhD-student at VU (A) Geeven, G.(2010, November 22). Computational statistics for the identification of transcriptional gene regulatory interactions. VU Vrije Universiteit. Prom./coprom.: prof. dr. M.C.M. de Gunst & R.E. van Kesteren. Vinkhuijzen, A.A.E. (2010, november 01). General cognitive ability and the interplay between genes and environment. VU Vrije Universiteit (242 pag.). Prom./coprom.: prof. dr. M. Verhage, prof. dr. P. Heutink, dr. D. Posthuma & Dr. S. van der Sluis. Scientific papers refereed Binsl, T.W., Alders, D.J.C., Heringa, J., Groeneveld, A.B.J. & Beek, J.H.G.M. van (2010). Computational quantification of metabolic fluxes from a single isotope snapshot: application to an animal biopsy. Bioinformatics, 26(5), Bossers, K., Ylstra, B., Brakenhoff, R.H., Smeets, S.J., Verhaagen, J. & Wiel, M.A. van de (2010). Intensity-based analysis of dual-color gene expression data as an alternative to ratio-based analysis to enhance reproducibility. BMC Genomics, 11, 112. Elburg, R.A.J. van & Ooyen, A. van (2010). Impact of Dendritic Size and Dendritic Topology on Burst Firing in Pyramidal Cells. PLoS Computational Biology, 6(5), e Furberg, H., Kim, Y.J., Dackor, J., Boerwinkle, E., Franceschini, N., Ardissino, D., Bernardinelli, L., Mannucci, P.M., Mauri, F., Merlini, P.A., Penninx, B.W.J.H., Smit, J.H., Vogelzangs, N., Boomsma, D.I., Geus, E.J.C. de, Vink, J.M., Willemsen, G., Tiemeier, H., Uitterlinden, A.G., Duijn, C.M. van, Maes, H.H., Audrain-McGovern, J., Posthuma, D., Thornton, L.M., Lerman, C., Kaprio, J., Rose, J.E., Ioannidis, J.P.A., Kraft, P., Lin, D.-Y. & Sullivan, P.F. (2010). Genome-wide meta-analyses identify multiple loci associated with smoking behavior. Nature Genetics, 42(5), Hunter, P., Coveney, P.V., Bono, B. de, Diaz, V., Fenner, J., Frangi, A.F., Harris, P., Hose, R., Kohl, P., Lawford, P., McCormack, K., Mendes, M., Omholt, S., Quarteroni, A., Skar, J., Tegner, J., Thomas, S.R., Tollis, I., Tsamardinos, I., Beek, J.H.G.M. van & Viceconti, M. (2010). A vision and strategy for the virtual physiological human in 2010 and beyond. Philosophical Transactions of the Royal Society A. Mathematical, Physical and Engineering Sciences, 368(1920), Ingebrigtsen, T., Thomsen, S.F., Vestbp, J., Sluis, S. van der, Kyvik, K.O., Silverman, E.K., Svartengren, M. & Backer, V. (2010). Genetic influences on chronic obstructive pulmonary disease - A twin study. Respiratory Medicine, 104(12), Jonker, M.A. & Boomsma, D.I. (2010). A frailty model for (interval) censored family survival data, applied to the age at onset of non-physical problems. Lifetime data analysis, 16, Kim, K.I., Roquain, E & Wiel, M.A. van de (2010). Spatial Clustering of Array CGH Features in Combination with Hierarchical Multiple Testing. Statistical Applications in Genetics and Molecular Biology, 9(1),

85 Kooistra, A.J., Binsl, T.W., Beek, J.H.G.M. van, Graaf, C. de & Heringa, J. (2010). Electron density fingerprints (EDprints): virutal screening using assembled information of electron density. Journal of Chemical Information and Modeling, 50(10), Kruijer, W.T., Rousseau, J. & Vaart, A.W. van der (2010). Adaptive Bayesian density estimation with location-scale mixtures. Electronic Journal of Statistics, 4, Lei, H.D.W. van der, Berkel, C.G.M. van, Wieringen, W.N. van, Brenner, C., Feigenbaum, A., Mercimek-Mahmutoglu, S., Philippart, M., Tatli, B., Wassmer, E., Scheper, G.C. & Knaap, M.S. van der (2010). Genotype-phenotype correlation in vanishing white matter disease. Neurology, 75(17), Mast, J. de & Wieringen, W.N. van (2010). Modeling and evaluating repeatability and reproducibility of ordinal classifications. Technometrics, 52(1), Minica, C.C., Boomsma, D.I., Sluis, S. van der & Dolan, C.V. (2010). Genetic association in multivariate phenotypic data: Power in five models. Twin Research and Human Genetics, 13(6), Munck, J.C. de & Bijma, F. (2010). How are evoked responses generated? The need for a unified mathematical framework. Clinical Neurophysiology, 121(2), Pelt, J. van, Carnell, A., Ridder, A. de, Mansvelder, H.D. & Ooyen, A. van (2010). An algorithm for finding candidate synaptic sites. Frontiers in Computational Neuroscience, 4, 148. Roelfsema, P.R., Ooyen, A. van & Watanabe, T. (2010). Perceptual learning rules based on reinforcers and attention. Trends in Cognitive Sciences, 14(2), Ruano, D., Abecasis, G.R., Glaser, B., Lips, E.S., Cornelisse, L.N., Jong, A.P.H. de, Evans, D.M., Smith, D.G., Thimpson, N.J., Smit, A.B., Heutink, P., Verhage, M. & Posthuma, D. (2010). Functional Gene Group Analysis Reveals a Role of Synaptic Heterotrimeric G Proteins in Cognitive Ability. American Journal of Human Genetics, 86(2), Scheinin, A.I., Ferreira, J.A., Knuutila, S., Meijer, G.A., Wiel, M.A. van de & Ylstra, B. (2010). CGHpower: exploring sample size calculations for chromosomal copy number experiments. BMC Bioinformatics, 11, 331. Sluis, S. van der, Verhage, M., Posthuma, D. & Dolan, C.V. (2010). Phenotypic Complexity, Measurement Bias, and Poor Phenotypic Resolution Contribute to the Missing Heritability Problem in Genetic Association Studies. PLoS ONE, 5(11), e Steenweg, M.E., Vanderver, A., Blaser, S., Blizzi, A., Koning, T.J. de, Mancini, G.M.S., Wieringen, W.N. van, Barkhof, F. & Wolf, N.I. (2010). Magnetic resonance imaging pattern recognition in hypomyelinating disorders. Brain, 133(10), Teeuw, M.E., Henneman, L., Bochdanovits, Z., Heutink, P., Kuik, D.J., Cornel, M.C. & Kate, L.P. ten (2010). Do consanguineous parents of a child affected by an autosomal recessive disease have more DNA identical-by-descent than similarly-related parents with healthy offspring? Design of a case-control study. BMC Medical Genetics, 11. Tetzlaff C., Okujeni S., Eggert U., Wörgötter F., Butz M. (2010). Self-organized criticality in developing neuronal networks. PLoS Computational Biology, 6(12), e Thomsen, S.F., Sluis, S. van der, Kyvik, K.O., Skytthe, A. & Backer, V. (2010). Estimates of asthma heritability in a large twin sample. Clinical & Experimental Allergy, 40(7), Visscher, P.M. & Posthuma, D. (2010). Statistical Power to Detect Genetic Loci Affecting Environmental Sensitivity. Behavior Genetics, 40(5), Wieringen, W.N. van, Berkhof, J. & Wiel, M.A. van de (2010). A random coefficients model for regional co-expression associated with DNA copy number. Statistical Applications in Genetics and Molecular Biology, 9(1), 25. Scientific publications (books, monographs, book chapters, proceedings) Book Chapter Vinkhuyzen, A.A.E., Sluis, S. van der & Posthuma, D. (2010). Behavior Genetics. In Roland.A. Carlstedt (Ed.), Integrative Clinical Psychology, Psychiatry, and Behavioral Medicine: Perspectives, Practices, and Research (pp ). New York: Springer Publishing Company. 83

86 Advanced Technology Programs: PHOTONICS & LIFE CELL IMAGING Theses VU/VUmc PhD-student at VU (A) Heistek, T.S. (2010, november 30). Controlling neuronal network oscillations with GABAergic inhibition. VU Vrije Universiteit (96 pag.). Prom./coprom.: prof. dr. A.B. Brussaard & prof. dr. H.D. Mansvelder. Scientific publications (books, monographs, book chapters, proceedings) Book Chapter Witte, S.M., Negrean, A., Lodder, J.C., Silva, G., Kock, C.P.J. de, Mansvelder, H.D. & Groot, M.L. (2010). Label-Free Live Brain Imaging with Ultrafast Nonlinear Microscopy. In M. Chergui (Ed.), Ultrafast Phenomena XVII: Proceedings of the 17th International Conference (pp ). New York: Oxford University Press. Genes and the Brain: ATTENTION & COGNITION Theses VU/VUmc PhD-student at VU (A) Counotte, D.S. (2010, oktober 08). The neurobiology of adolescent nicotine exposure. VU Vrije Universiteit (186 pag.). Prom./coprom.: prof. dr. A.B. Smit, dr. S. Spijker, dr. T. Pattij & prof. dr. H.D. Mansvelder. Heistek, T.S. (2010, november 30). Controlling neuronal network oscillations with GABAergic inhibition. VU Vrije Universiteit (96 pag.). Prom./coprom.: prof. dr. A.B. Brussaard & prof. dr. H.D. Mansvelder. Vinkhuijzen, A.A.E. (2010, november 01). General cognitive ability and the interplay between genes and environment. VU Vrije Universiteit (242 pag.). Prom./coprom.: prof. dr. M. Verhage, prof. dr. P. Heutink, dr. D. Posthuma & Dr. S. van der Sluis. Theses external PhD-student at VU (B) Pooresmaeili, A. (2010, april 07). Neuronal basis of visual perception and attention in visual and frontal cortex. VU Vrije Universiteit (218 pag.). Prom./coprom.: prof. dr. P.R. Roelfsema. Scientific papers refereed Altena, E., Ramautar, J.R., Werf, Y.D. van der & Someren, E.J.W. van (2010). Do sleep complaints contribute to age-related cognitive decline? Progress in Brain Research, 185, Altena, E., Vrenken, H., Werf, Y.D. van der, Heuvel, O.A. van den & Someren, E.J.W. van (2010). Reduced Orbitofrontal and Parietal Gray Matter in Chronic Insomnia: A Voxel-Based Morphometric Study. Biological Psychiatry, 67(2), Axelsson, J., Sundelin, T., Ingre, M., Someren, E.J.W. van, Olsson, A. & Lekander, M. (2010). CHRISTMAS 2010: RESEARCH Beauty sleep: experimental study on the perceived health and attractiveness of sleep deprived people. British Medical Journal, 341. Beijsterveldt, C.E.M. van, Felsenfeld, S. & Boomsma, D.I. (2010). Bivariate genetic analyses of stuttering and nonfluency in a large sample of 5-year old twins. Journal of Speech, Language and Hearing Research, 53, Boomsma, D.I., Savyuk, V., Hottenga, J.J., Distel, M.A., Moor, M.H.M. de, Vink, J.M., Geels, L.M., Beek, J.H.D.A. van, Bartels, M., Geus, E.J.C. de & Willemsen, G. (2010). Genetic epidemiology of Attention Deficit Hyperactivity Disorder (ADHD Index) in adults. PLoS ONE, 5(5), e Brans, R.G.H., Kahn, R.S., Schnack, H.G., Baal, G.C.M. van, Posthuma, D., Haren, N.E.M. van, Lepage, C., Lerch, J.P., Collins, D.L., Evans, A.C., Boomsma, D.I. & Hulshoff Pol, H.E. (2010). Brain Plasticity and Intellectual Ability Are Influenced by Shared Genes. Journal of Neuroscience, 30(16), Colzato, L., Waszak, F., Nieuwenhuis, S., Posthuma, D. & Hommel, B. (2010). The flexible mind is associated with the catechol-o-methyltransferase (COMT) Val(158)Met polymorphism: Evidence for a role of dopamine in the control of task-switching. Neuropsychologia, 48(9),

87 Counotte, D.S., Li, K.W., Wortel, J., Gouwenberg, Y., Schors, R.C. van der, Smit, A.B. & Spijker, S. (2010). Changes in molecular composition of rat medial prefrontal cortex synapses during adolescent development. European Journal of Neuroscience, 32(9), Dupuis, J., Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., Jackson, A.U., Wheeler, E., Glazer, N.L., Bouatia-Naji, N., Gloyn, A.L., Lindgren, C.M., Mägi, R., Morris, A.P., Randall, J., Johnson, T., Hottenga, J.J., Geus, E.J.C. de, Kaprio, J., Kyvik, K.O., Pedersen, N.L., Perola, M., Posthuma, D., Rivadeneira, F., Uitterlinden, A.G., Willems van Dijk, K., Hoek, M. van, Vogelzangs, N., Willemsen, G., Witteman, J.C.M., Zillikens, M.C., Penninx, B.W.J.H., Boomsma, D.I., Duijn, C.M. van, Aulchenko, Y.S., Waterworth, D., Vollenweider, P., Peltonen, L., Mooser, V., Abecasis, G.R., Wareham, N.J., Sladek, R., Froguel, P., Watanabe, R.M., Meigs, J.B., Groop, L.C., Boehnke, M., McCarthy, M.I., Florez, J.C. & Barroso, I. (2010). New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nature Genetics, 42(2), Fecteau, J. H., Roelfsema, P.R., Zeeuw, C.I. & Kousta, S. (2010). Perceptual learning, motor learning, and automaticity. Trends in Cognitive Sciences, 14(1), 1-1. Felsenfeld, S., Beijsterveldt, C.E.M. van & Boomsma, D.I. (2010). Attentional Regulation in Young Twins With Probable Stuttering, High Nonfluency, and Typical Fluency. Journal of Speech, Language and Hearing Research, 53(5), Haworth, C.M.A., Wright, M.J., Luciano, M, Martin, N.G., Geus, E.J.C. de, Beijsterveldt, C.E.M. van, Bartels, M., Posthuma, D., Boomsma, D.I., Davis, O.S.P., Kovas, Y., Corley, R.P., DeFries, J.C., Hewitt, J.K., Olson, R.K., Rhea, S.-A., Wadsworth, S.J., Iacono, W.G., McGue, M., Thompson, L.A., Hart, S.A., Petrill, S.A., Lubinski, D. & Plomin, R. (2010). The heritability of general cognitive ability increases linearly from childhood to young adulthood. Molecular Psychiatry, 15(11), Heistek, T.S., Lodder, J.C., Brussaard, A.B., Bosman, L.W.J. & Mansvelder, H.D. (2010). GABAergic inhibition shapes frequency adaptation of cortical activity in a frequency-dependent manner. Brain Research, 1321, Houtkamp, R. & Roelfsema, P.R. (2010). Parallel and serial grouping of image elements in visual perception. Journal of Experimental Psychology. Human Perception and Performance, 36(6), Kello, C.T., Brown, G.D.A., Ferrer-i-Cancho, R., Holden, J.G., Linkenkaer-Hansen, K., Rhodes, T. & Orden, G.C. van (2010). Scaling laws in cognitive sciences. Trends in Cognitive Sciences, 14(5), Lind, P.A., Macgregor, S., Vink, J.M., Pergadia, M.L., Hansell, N., Moor, M.H.M. de, Smit, A.B., Hottenga, J.J., Richter, M., Heath, A.C., Martin, N.G., Willemsen, G., Geus, E.J.C. de, Vogelzangs, N., Penninx, B.W.J.H., Whitfield, J.B., Montgomery, GW, Boomsma, D.I. & Madden, P.A.F. (2010). A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations. Twin Research and Human Genetics, 13(1), Loos, M., Pattij, T., Janssen, M.C.W., Counotte, D.S., Schoffelmeer, A.N.M., Smit, A.B., Spijker, S. & Gaalen, M.M. van (2010). Dopamine Receptor D-1/D-5 Gene Expression in the Medial Prefrontal Cortex Predicts Impulsive Choice in Rats. Cerebral Cortex, 20(5), Loos, M., Staal, J., Schoffelmeer, A.N.M., Smit, A.B., Spijker, S. & Pattij, T. (2010). Inhibitory control and response latency differences between C57BL/6J and DBA/2J mice in a Go/No-Go and 5- choice serial reaction time task and strain-specific responsivity to amphetamine. Behavioural Brain Research, 214(2), Meyer, H.S., Wimmer, V.C., Hemberger, M., Bruno, R.M., Kock, C.P.J. de, Frick, A., Sakmann, B. & Helmstaedter, M. (2010). Cell-type specific thalamic innervation in a column of rat vibrissal cortex. Cerebral Cortex, 20(10), Meyer, H.S., Wimmer, V.C., Oberlaender, M., Kock, C.P.J. de, Sakmann, B. & Helmstaedter, M. (2010). Number and laminar distribution of neurons in a thalamocortical projection column of rat vibrissal cortex. Cerebral Cortex, 20(10), Minica, C.C., Boomsma, D.I., Sluis, S. van der & Dolan, C.V. (2010). Genetic association in multivariate phenotypic data: Power in five models. Twin Research and Human Genetics, 13(6), Moro, S.I., Tolboom, M., Khayat, P.S. & Roelfsema, P.R. (2010). Neuronal Activity in the Visual Cortex Reveals the Temporal Order of Cognitive Operations. Journal of Neuroscience, 30(48), Nikulin, V.V., Linkenkaer-Hansen, K., Nolte, G. & Curio, G. (2010). Non-zero mean and asymmetry of neuronal oscillations have different implications for evoked responses. Clinical Neurophysiology, 121(2),

88 Peper, J.S., Brouwer, R.M., Leeuwen, M. van, Schnack, H.G., Boomsma, D.I., Kahn, R.S. & Hulshoff- Poll, H.E. (2010). HPG-axis hormones during puberty: A study on the association with hypothalamic and pituitary volumes. Psychoneuroendocrinology, 35(1), Polderman, J.C., Bartels, M., Verhulst, F.C., Huizink, A.C., Beijsterveldt, C.E.M. van & Boomsma, D.I. (2010). No effect of classroom sharing on educational achievement in twins: a prospective, longitudinal cohort study. Journal of Epidemiology and Community Health, 64(1), Polderman, T.J.C., Boomsma, D.I., Bartels, M., Verhulst, F.C. & Huizink, A.C. (2010). A systematic review of prospective studies on attention problems and academic achievement. Acta Psychiatrica Scandinavica, 122, Pooresmaeili, A., Poort, J., Thiele, A. & Roelfsema, P.R. (2010). Separable Codes for Attention and Luminance Contrast in the Primary Visual Cortex. Journal of Neuroscience, 30(38), Pooresmaeili, A., Herrero, J.L., Self, M.W. & Roelfsema, P.R. (2010). Suppressive Lateral Interactions at Parafoveal Representations in Primary Visual Cortex. Journal of Neuroscience, 30(38), Roelfsema, P.R., Houtkamp, R. & Korjoukov, I. (2010). Further evidence for the spread of attention during contour grouping: a reply to Crundall, Dewhurst, and Underwood (2008). Attention, Perception & Psychophysics, 72(3), Roelfsema, P.R., Ooyen, A. van & Watanabe, T. (2010). Perceptual learning rules based on reinforcers and attention. Trends in Cognitive Sciences, 14(2), Ruano, D., Abecasis, G.R., Glaser, B., Lips, E.S., Cornelisse, L.N., Jong, A.P.H. de, Evans, D.M., Smith, D.G., Thimpson, N.J., Smit, A.B., Heutink, P., Verhage, M. & Posthuma, D. (2010). Functional Gene Group Analysis Reveals a Role of Synaptic Heterotrimeric G Proteins in Cognitive Ability. American Journal of Human Genetics, 86(2), Self, M.W. & Roelfsema, P.R. (2010). A monocular, unconscious form of visual attention. Journal of Vision, 10(4), 17/1-23. Sluis, S. van der, Kan, K.J. & Dolan, C.V. (2010). Consequences of a network view for genetic association studies. Behavioral and Brain Sciences, 33(2-3), Sluis, S. van der, Vinkhuyzen, A.A.E., Boomsma, D.I. & Posthuma, D. (2010). Sex differences in adults' motivation to achieve. Intelligence, 38(4), Smit, D.J.A., Boersma, M., Beijsterveldt, C.E.M. van, Posthuma, D., Boomsma, D.I., Stam, C.J. & Geus, E.J.C. de (2010). Endophenotypes in a Dynamically Connected Brain. Behavior Genetics, 40(2), Soelen, I.L.C. van, Brouwer, R.M., Peper, J.S., Beijsterveldt, C.E.M. van, Leeuwen, M. van, Vries, L.S. de, Kahn, R.S., Hulshoff Pol, H.E. & Boomsma, D.I. (2010). Effects of Gestational Age and Birth Weight on Brain Volumes in Healthy 9 Year-Old Children. Journal of Pediatrics, 156(6), Someren, E.J.W. van (2010). Doing with less sleep remains a dream. Proceedings of the National Academy of Sciences of the United States of America, 107(37), Turner, P.L., Someren, E.J.W. van & Mainster, M.A. (2010). The role of environmental light in sleep and health: Effects of ocular aging and cataract surgery. Sleep Medicine Reviews, 14(4), Veen, M.M. van, Kooij, J.J.S, Boonstra, A. M., Gordijn, M.C.M. & Someren, E.J.W. van (2010). Delayed Circadian Rhythm in Adults with Attention-Deficit/Hyperactivity Disorder and Chronic Sleep-Onset Insomnia. Biological Psychiatry, 67(11), Vinkhuijzen, A.A.E., Sluis, S. van der, Geus, E.J.C. de, Boomsma, D.I. & Posthuma, D. (2010). Genetic influences on 'environmental factors. Genes, Brain and Behavior, 9(3), Vinkhuijzen, A.A.E., Sluis, S. van der, Boomsma, D.I., Geus, E.J.C. de & Posthuma, D. (2010). Individual differences in processing speed and working memory speed as assessed with the Sternberg Memory Scanning Task. Behavior Genetics, 40(3), Werf, Y.D. van der, Altena, E., Dijk, K.D. van, Strijers, R.L.M., Ruke, W. De, Stam, C.J. & Someren, E.J.W. van (2010). Is Disturbed Intracortical Excitability a Stable Trait of Chronic Insomnia? A Study Using Transcranial Magnetic Stimulation Before and After Multimodal Sleep Therapy. Biological Psychiatry, 68(10), Werken, M. van de, Gimenez, M.C., Vries, B. de, Beersma, D.G.M., Someren, E.J.W. van & Gordijn, M.C.M. (2010). Effects of artificial dawn on sleep inertia, skin temperature, and the awakening cortisol response. Journal of Sleep Research, 19(3), Willemsen, G., Geus, E.J.C. de, Bartels, M., Beijsterveldt, C.E.M. van, Brooks, A.I., Estourgie - van Burk, G.F., Fugman, D.A., Hoekstra, C., Hottenga, J.J., Kluft, C., Meijer, P., Montgomery, GW, Rizzu, P., Sondervan, D., Smit, A.B., Spijker, S., Suchiman, H.E.D., Tischfield, J.A., Lehner, T., Slagboom, P.E. & Boomsma, D.I. (2010). The Netherlands Twin Register Biobank: A resource for genetic epidemiological studies. Twin Research and Human Genetics, 13(3),

89 Wimmer, V.C., Bruno, R.M., Kock, C.P.J. de, Kuner, T. & Sakmann, B. (2010). Dimensions of a projection column and architecture of VPM- and POm-axons in rat vibrissal cortex. Cerebral Cortex, 20(10), Zylberberg, A., Fernández Slezak, D., Roelfsema, P.R., Dehaene, S. & Sigman, M. (2010). The Brain's Router: A Cortical Network Model of Serial Processing in the Primate Brain. PLoS Computational Biology, 6(4), e Professional publications Someren, E.J.W. van (2010). Wakker liggen van slapeloosheid (2010, november 25). Amsterdam: Vrije Universiteit. Genes and the Brain: ADDICTIVE BEHAVIOR Scientific papers refereed Berg, L. van den, Berg, S.M. van den, Martens, E.E.C.P., Hazewinkel, H.A.W., Dijkshoorn, N.A., Delemarre-van de Waal, H.A., Heutink, P., Leegwater, P.A. & Heuven, H.C.M. (2010). Analysis of variation in the melanocortin-4 receptor gene (mc4r) in golden retriever dogs. Animal Genetics, 41(5), Berg, L. van den, Waal, H.A. Delemarre-van d, Han, J.C., Ylstra, B., Eijk, P., Nesterova, M., Heutink, P. & Stratakis, C.A. (2010). Investigation of a Patient With a Partial Trisomy 16q Including the Fat Mass and Obesity Associated Gene (FTO): Fine Mapping and FTO Gene Expression Study. American Journal of Medical Genetics Part A, 152A(3), Boschloo, L., Vogelzangs, N., Smit, J.H., Brink, W. van den, Veltman, D.J., Beekman, A.T.F. & Penninx, B.W.J.H. (2010). The performance of the Alcohol Use Disorder Identification Test (AUDIT) in detecting alcohol abuse and dependence in a population of depressed or anxious persons. Journal of Affective Disorders, 126(3), Frohmader, K.S., Wiskerke, J., Wise, R.A., Lehman, M.N. & Coolen, L.M. (2010). Methamphetamine Acts on Subpopulations of Neurons Regulating Sexual Behavior in Male Rats. Neuroscience, 166(3), Furberg, H., Kim, Y.J., Dackor, J., Boerwinkle, E., Franceschini, N., Ardissino, D., Bernardinelli, L., Mannucci, P.M., Mauri, F., Merlini, P.A., Penninx, B.W.J.H., Smit, J.H., Vogelzangs, N., Boomsma, D.I., Geus, E.J.C. de, Vink, J.M., Willemsen, G., Tiemeier, H., Uitterlinden, A.G., Duijn, C.M. van, Maes, H.H., Audrain-McGovern, J., Posthuma, D., Thornton, L.M., Lerman, C., Kaprio, J., Rose, J.E., Ioannidis, J.P.A., Kraft, P., Lin, D.-Y. & Sullivan, P.F. (2010). Genome-wide meta-analyses identify multiple loci associated with smoking behavior. Nature Genetics, 42(5), Gaalen, M.M., Schetters, D., Schoffelmeer, A.N.M. & Vries, T.J. de (2010). 5-HT6 antagonism attenuates cue-induced relapse to cocaine seeking without affecting cocaine reinforcement. International Journal of Neuropsychopharmacology, 13(7), Guillem K., Peoples L.L. (2010). Progressive and lasting amplification of accumbal nicotine-seeking neural signals. Journal of Neuroscience, 30(1) Holst, R.J. van, Brink, W. van den, Veltman, D.J. & Goudriaan, A.E. (2010). Why gamblers fail to win: A review of cognitive and neuroimaging findings in pathological gambling. Neuroscience and Biobehavioral Reviews, 34(1), Lind, P.A., Macgregor, S., Vink, J.M., Pergadia, M.L., Hansell, N., Moor, M.H.M. de, Smit, A.B., Hottenga, J.J., Richter, M., Heath, A.C., Martin, N.G., Willemsen, G., Geus, E.J.C. de, Vogelzangs, N., Penninx, B.W.J.H., Whitfield, J.B., Montgomery, GW, Boomsma, D.I. & Madden, P.A.F. (2010). A genomewide association study of nicotine and alcohol dependence in Australian and Dutch populations. Twin Research and Human Genetics, 13(1), Loos, M., Pattij, T., Janssen, M.C.W., Counotte, D.S., Schoffelmeer, A.N.M., Smit, A.B., Spijker, S. & Gaalen, M.M. van (2010). Dopamine Receptor D-1/D-5 Gene Expression in the Medial Prefrontal Cortex Predicts Impulsive Choice in Rats. Cerebral Cortex, 20(5), Loos, M., Staal, J., Schoffelmeer, A.N.M., Smit, A.B., Spijker, S. & Pattij, T. (2010). Inhibitory control and response latency differences between C57BL/6J and DBA/2J mice in a Go/No-Go and 5- choice serial reaction time task and strain-specific responsivity to amphetamine. Behavioural Brain Research, 214(2),

90 Oever, M.C. van den, Lubbers, B.R., Goriounova, N.A., Li, K.W., Schors, R.C. van der, Loos, M., Riga, D., Wiskerke, J., Binnekade, R., Stegeman, M., Schoffelmeer, A.N., Mansvelder, H.D., Smit, A.B., Vries, T.J. de & Spijker, S. (2010). Extracellular matrix plasticity and GABAergic inhibition of prefrontal cortex pyramidal cells facilitates relapse to heroin seeking. Neuropsychopharmacology, 35(10), Oever, M.C. van den, Spijker, S., Smit, A.B. & Vries, T.J. de (2010). Prefrontal cortex plasticity mechanisms in drug seeking and relapse. Neuroscience and Biobehavioral Reviews, 335(2), Peters, J., Dieppa-Perea, L.M., Melendez, L.M. & Quirk, G.J. (2010). Induction of Fear Extinction with Hippocampal-Infralimbic BDNF. Science, 328(5983), Spijker, S., Zanten, J.S. van, Jong, S de, Penninx, B.W.J.H., Dyck, R. van, Zitman, F.G., Smit, J.H., Ylstra, B., Smit, A.B. & Hoogendijk, W.J.G. (2010). Stimulated Gene Expression Profiles as a Blood Marker of Major Depressive Disorder. Biological Psychiatry, 68(2), Talens, R.P., Boomsma, D.I., Tobi, E.W., Kremer, D., Jukema, J.W., Willemsen, G., Putter, H., Slagboom, P.E. & Heijmans, B.T. (2010). Variation, patterns, and temporal stability of DNA methylation: considerations for epigenetic epidemiology. FASEB Journal, 24(9), Thorgeirsson, T.E., Gudbjartsson, D.F., Surakka, I., Vink, J.M., Amin, N., Geller, F., Sulem, P., Rafnar, T., Esko, T., Walter, S., Gieger, C., Rawal, R., Mangino, M., Prokopenko, I., Magi, R., Keskitalo, K., Gudjonsdottir, I.H., Gretarsdottir, S., Stefansson, H., Thompson, J.R., Aulchenko, Y.S., Nelis, M., Aben, K.K., Heijer, M., Dirksen, A., Ashraf, H., Soranzo, N., Valdes, A.M., Steves, C., Uitterlinden, A.G., Hofman, A., Tonjes, A., Kovacs, P., Hottenga, J.J., Willemsen, G., Vogelzangs, N., Doring, A., Dahmen, N., Nitz, B., Pergadia, M.L., Saez, B., Diego, V. De, Lezcano, V., Garcia-Prats, M.D., Ripatti, S., Perola, M., Kettunen, J., Hartikainen, A.L., Pouta, A., Laitinen, J., Isohanni, M., Huei-Yi, S., Allen, M., Krestyaninova, M., Hall, A.S., Jones, G.T., Rij, A.M. van, Mueller, T., Dieplinger, B., Haltmayer, M., Jonsson, S., Matthiasson, S.E., Oskarsson, H., Tyrfingsson, T., Kiemeney, L.A., Mayordomo, J.I., Lindholt, J.S., Pedersen, J.H., Franklin, W.A., Wolf, H. de, Montgomery, GW, Heath, A.C., Martin, N.G., Madden, P.A.F., Giegling, I., Rujescu, D., Jarvelin, M.R., Salomaa, V., Stumvoll, M., Spector, T.D., Wichmann, H.E., Metspalu, A., Samani, N.J., Penninx, B.W., Oostra, B.A., Boomsma, D.I., Tiemeier, H., Duijn, C.M. van, Kaprio, J., Gulcher, J.R., McCarthy, M.I., Peltonen, L., Thorsteinsdottir, U. & Stefansson, K. (2010). Sequence variants at CHRNB3-CHRNA6 and CYP2A6 affect smoking behavior. Nature Genetics, 42(5), Verweij, K.J.H., Zietsch, B.P., Lynskey, M.T., Medland, S.E., Neale, M.C., Martin, N.G., Boomsma, D.I. & Vink, J.M. (2010). Genetic and environmental influences on cannabis use initiation and problematic use: a meta-analysis of twin studies. Addiction, 105(3), Vink, J.M., Wolters, L.M.C., Neale, M.C. & Boomsma, D.I. (2010). Heritability of cannabis initiation in Dutch adult twins. Addictive Behaviors, 35(2), Wouda, J.A., Diergaarde, L., Riga, D., Mourik, Y. van, Schoffelmeer, A.N.M. & Vries, T.J. de (2010). Disruption of long-term alcohol-related memory reconsolidation: role of â-adrenoceptors and NMDA receptors. Frontiers in Behavioral Neuroscience, 4, 179. Genes and the Brain: SYSTEMS BIOLOGY OF THE SYNAPSE Theses VU/VUmc PhD-student at VU (A) Dudok, J.J. (2010, september 29). Cellular characterization of the outgrowth and connectivity of the brain serotonin system. VU Vrije Universiteit (165 pag.). Prom./coprom.: prof. dr. M. Verhage & dr. ir. A.J.A. Groffen. Heistek, T.S. (2010, november 30). Controlling neuronal network oscillations with GABAergic inhibition. VU Vrije Universiteit (96 pag.). Prom./coprom.: prof. dr. A.B. Brussaard & prof. dr. H.D. Mansvelder. Scientific papers refereed Broeke, J.H.P., Roelandse, M.J.L., Luteijn, M.J., Boiko, T., Matus, A., Toonen, R.F. & Verhage, M. (2010). Munc18 and Munc13 regulate early neurite outgrowth. Biology of the Cell, 102(8), Engelhardt, J., Mack, V., Sprengel, R., Kavenstock, N., Li, K.W., Stern-Bach, Y., Smit, A.B., Seeburg, P.H. & Monyer, H. (2010). CKAMP44: A Brain-Specific Protein Attenuating Short-Term Synaptic Plasticity in the Dentate Gyrus. Science, 327(5972),

91 Geitmann, M., Retra, K., Kloe, G.E. de, Homan, E., Smit, A.B., Esch, I.J.P. de & Danielson, U.H. (2010). Interaction Kinetic and Structural Dynamic Analysis of Ligand Binding to Acetylcholine- Binding Protein. Biochemistry, 49(37), Groffen, A.J., Martens, S., Diez Arazola, R., Cornelisse, L.N., Lozovaya, N., Jong, A.P.H. de, Goriounova, N.A., Habets, R.L., Takai, Y., Borst, J.G., Brose, N., McMahon, H.T. & Verhage, M. (2010). Doc2b is a high-affinity Ca2+ sensor for spontaneous neurotransmitter release. Science, 327(5973), Heistek, T.S., Timmerman, A.J., Spijker, S., Brussaard, A.B. & Mansvelder, H.D. (2010). GABAergic synapse properties may explain genetic variation in hippocampal network oscillations in mice. Frontiers in Cellular Neuroscience, 4, 18. Heus, F., Giera, M.A., Kloe, G.E. de, Iperen, D. van, Buijs, J.B., Nahar, T.T., Smit, A.B., Lingeman, H., Esch, I.J.P. de, Niessen, W.M.A., Irth, H. & Kool, J. (2010). Development of a microfluidic confocal fluorescence detection system for the hyphenation of nano-lc to on-line biochemical assays. Analytical and Bioanalytical Chemistry, 398(7-8), Islinger, M., Li, K.W., Loos, M., Liebler, S., Angermuller, S., Eckerskorn, C, Weber, G., Abdolzade, A. & Volkl, A. (2010). Peroxisomes from the Heavy Mitochondrial Fraction: Isolation by Zonal Free Flow Electrophoresis and Quantitative Mass Spectrometrical Characterization. Journal of Proteome Research, 9(1), Kloe, G.E. de, Retra, K., Geitmann, M., Kallblad, B., Nahar, T.T., Elk, R. van, Smit, A.B., Muijlwijk- Koezen, J.E. van, Leurs, R., Irth, H., Danielson, U.H. & Esch, I.J.P. de (2010). Surface Plasmon Resonance Biosensor Based Fragment Screening Using Acetylcholine Binding Protein Identifies Ligand Efficiency Hot Spots (LE Hot Spots) by Deconstruction of Nicotinic Acetylcholine Receptor alpha 7 Ligands. Journal of Medicinal Chemistry, 53(19), Klychnikov, O.I., Li, K.W., Sidorov, I.A., Loos, M., Spijker, S., Broos, L.A.M., Frants, R.R., Ferrari, M.D., Mayboroda, O.A., Deelder, A.M., Smit, A.B. & Maagdenberg, A.M.J.M. van den (2010). Quantitative cortical synapse proteomics of a transgenic migraine mouse model with mutated Ca(v)2.1 calcium channels. Proteomics, 10(13), Kool, J., Kloe, G.E. de, Bruyneel, B., Vlieger, J.S.B., Retra, K., Wijtmans, M., Elk, R. van, Smit, A.B., Leurs, R., Lingeman, H., Esch, I.J.P. de & Irth, H. (2010). Online Fluorescence Enhancement Assay for the Acetylcholine Binding Protein with Parallel Mass Spectrometric Identification. Journal of Medicinal Chemistry, 53(12), Li, K.W., Klemmer, P. & Smit, A.B. (2010). Interaction proteomics of synapse protein complexes. Analytical and Bioanalytical Chemistry, 397(8), Li, K.W. & Smit, A.B. (2010). Mass spectrometric analysis of molluscan neuropeptides. Methods in Molecular Biology, 615, Meredith, R.M. & Groen, M.R. (2010). Inhibition of Action Potential Backpropagation During Postnatal Development of the Hippocampus. Journal of Neurophysiology, 103(4), Meredith, R.M. & Mansvelder, H.D. (2010). STDP and mental retardation: dysregulation of dendritic excitability in Fragile X syndrome. Frontiers in Synaptic Neuroscience, 2, 10. Min, R., Di Marzo, V. & Mansvelder, H.D. (2010). DAG Lipase Involvement in Depolarization-Induced Suppression of Inhibition: Does Endocannabinoid Biosynthesis Always Meet the Demand? Neuroscientist, 16(6), Min, R., Testa-Silva, G., Heistek, T.S., Canto, C.B., Lodder, J.C., Bisogno, T., Marzo, V. di, Brussaard, A.B., Burnashev, N. & Mansvelder, H.D. (2010). Diacylglycerol Lipase Is Not Involved in Depolarization-Induced Suppression of Inhibition at Unitary Inhibitory Connections in Mouse Hippocampus. Journal of Neuroscience, 30(7), Mischerikow, N., Nierop, P. van, Li, K.W., Bernstein, H.G., Smit, A.B., Heck, A.J.R. & Altelaar, A.F.M. (2010). Gaining efficiency by parallel quantification and identification of itraq-labeled peptides using HCD and decision tree guided CID/ETD on an LTQ Orbitrap. Analyst, 135(10), Mohrman, R., Wit, H. de, Verhage, M., Neher, E. & Sørensen, J.B. (2010). Fast Vesicle Fusion in Living Cells Requires at Least Three SNARE Complexes. Science, 330(6003), Nikulin, V.V., Linkenkaer-Hansen, K., Nolte, G., Palva, M.J. & Curio, G. (2010). Non-zero mean of oscillations as a mechanism for the generation of evoked responses. Clinical Neurophysiology, 121(7), Retra, K., Geitmann, M., Kool, J., Smit, A.B., Esch, I.J.P. de, Danielson, U.H. & Irth, H. (2010). Development of surface plasmon resonance biosensor assays for primary and secondary screening of acetylcholine binding protein ligands. Analytical Biochemistry, 407(1), Schonn, J.S., Weering, J.R.T. van, Mohrman, R., Schlüter, O.M., Südhof, T.C., Wit, H. de, Verhage, M. & Sørensen, J.B. (2010). Rab3 Proteins Involved in Vesicle Biogenesis and Priming in Embryonic Mouse Chromaffin Cells. Traffic, 11(11),

92 Testa-Silva, G., Verhoog, M.B., Goriounova, N.A., Loebel, A., Hjorth, J., Baayen, J.C., Kock, C.P.J. de & Mansvelder, H.D. (2010). Human synapses show a wide temporal window for spike-timingdependent plasticity. Frontiers in Synaptic Neuroscience, 2, 12. Vinkhuijzen, A.A.E., Sluis, S. van der, Geus, E.J.C. de, Boomsma, D.I. & Posthuma, D. (2010). Genetic influences on 'environmental factors. Genes, Brain and Behavior, 9(3), Wit, H. de (2010). Molecular mechanism of secretory vesicle docking. Biochemical Society Transactions, 38, Wit, H. de (2010). Morphological docking of secretory vesicles. Histochemistry and Cell Biology, 134(2), Scientific publications (books, monographs, book chapters, proceedings) Book Chapter Ögren, S.O. & Stiedl, O. (2010). Passive avoidance. In I.P. Stolerman (Ed.), Encyclopedia of Psychopharmacology, Vol 2 (pp ). Berlin: Springer. Stiedl, O., Youn, J.U. & Jansen, R.F. (2010). Cardiovascular conditioning: neural substrates. In G. Koob, R.F. Thompson & M. Le Moal (Eds.), Encyclopedia of Behavioral Neurosciences, Vol. 1 (pp ). Amsterdam: Elsevier. Brain Disease Mechanisms: ANXIETY & DEPRESSION Theses VU/VUmc PhD-student at VU (A) Altena, E. (2010, maart 17). Mapping insomnia: brain structure, functon and sleep intervention. VU Vrije Universiteit. Prom./coprom.: prof. dr. E.J. van Someren, prof. dr. D.F. Swaab, dr. Y.D. van der Werf & prof. dr. P. Scheltens. Vreeburg, S.A. (2010, oktober 22). Hypothalamic-pituitary-adrenal axis in depressive and anxiety disorders. VU Vrije Universiteit. Prom./coprom.: prof. dr. B.W.J.H. Penninx & prof. dr. W.J.G. Hoogendijk. Scientific papers refereed Altena, E., Vrenken, H., Werf, Y.D. van der, Heuvel, O.A. van den & Someren, E.J.W. van (2010). Reduced Orbitofrontal and Parietal Gray Matter in Chronic Insomnia: A Voxel-Based Morphometric Study. Biological Psychiatry, 67(2), Beekman, M., Nederstigt, C., Suchiman, H.E.D., Kremer, D., Breggen, R. van der, Lakenberg, N., Alemayehu, W.G., Craen, A.J. de, Westendorp, R.G.J., Boomsma, D.I., Geus, E.J.C. de, Houwing-Duistermaat, J.J., Heijmans, B.T. & Slagboom, P.E. (2010). Genome-wide association study (GWAS)-identified disease risk alleles do not compromise human longevity. Proceedings of the National Academy of Sciences of the United States of America, 107(42), Chambers, J.C., Zhang, W.H., Lord, G.M., Harst, P. van der, Lawlor, D.A., Sehmi, J.S., Gale, D.P., Wass, M.N., Ahmadi, K.R., Bakker, J. L., Beckmann, J., Bilo, H.J.G., Bochud, M., Brown, M.J., Caulfield, M.J., Connell, J.M.C., Cook, H.T., Cotlarciuc, I., Smith, G.D., Silva, R. de, Deng, G.H., Devuyst, O., Dikkeschei, L.D., Dimkovic, N., Dockrell, M., Dominiczak, A., Ebrahim, S., Eggermann, T., Farrall, M., Ferrucci, L., Floege, J., Forouhi, N.G., Gansevoort, R.T., Han, X.J., Hedblad, B., Heide, J.J.H. van der, Hepkema, B.G., Hernandez-Fuentes, M., Hypponen, E., Johnson, T., Jong, P.E. de, Kleefstra, N., Lagou, V., Lapsley, M., Li, Y., Loos, R.J.F., Luan, J., Luttropp, K., Marechal, C., Melander, O., Munroe, P.B., Nordfors, L., Parsa, A., Peltonen, L., Penninx, B.W., Perucha, E., Pouta, A., Prokopenko, I., Roderick, P.J., Ruokonen, A., Samani, N.J., Sanna, S., Schalling, M., Schlessinger, D., Schlieper, G., Seelen, M.A.J., Shuldiner, A.R., Sjogren, M., Smit, J.H., Snieder, H., Soranzo, N., Spector, T.D., Stenvinkel, P., Sternberg, M.J.E., Swaminathan, R., Tanaka, T., Ubink-Veltmaat, L.J., Uda, M., Vollenweider, P., Wallace, C., Waterworth, D., Zerres, K., Waeber, G., Wareham, N.J., Maxwell, P.H., McCarthy, M.I., Jarvelin, M.R., Mooser, V., Abecasis, G.R., Lightstone, L., Scott, J., Navis, G., Elliott, P. & Kooner, J.S. (2010). Genetic loci influencing kidney function and chronic kidney disease. Nature Genetics, 42(5), Dorrepaal, E., Thomaes, K., Smit, J.H., Balkom, A.J.L.M. van, Dyck, R. van, Veltman, D.J. & Draijer, P.J. (2010). Stabilizing group treatment for Complex Posttraumatic Stress Disorder related to childhood abuse based on psycho-education and cognitive behavioral therapy: A pilot study. Child Abuse & Neglect, 34(4),

93 Dupuis, J., Langenberg, C., Prokopenko, I., Saxena, R., Soranzo, N., Jackson, A.U., Wheeler, E., Glazer, N.L., Bouatia-Naji, N., Gloyn, A.L., Lindgren, C.M., Mägi, R., Morris, A.P., Randall, J., Johnson, T., Hottenga, J.J., Geus, E.J.C. de, Kaprio, J., Kyvik, K.O., Pedersen, N.L., Perola, M., Posthuma, D., Rivadeneira, F., Uitterlinden, A.G., Willems van Dijk, K., Hoek, M. van, Vogelzangs, N., Willemsen, G., Witteman, J.C.M., Zillikens, M.C., Penninx, B.W.J.H., Boomsma, D.I., Duijn, C.M. van, Aulchenko, Y.S., Waterworth, D., Vollenweider, P., Peltonen, L., Mooser, V., Abecasis, G.R., Wareham, N.J., Sladek, R., Froguel, P., Watanabe, R.M., Meigs, J.B., Groop, L.C., Boehnke, M., McCarthy, M.I., Florez, J.C. & Barroso, I. (2010). New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nature Genetics, 42(2), Franic, S.F., Middeldorp, C.M., Dolan, C.V., Ligthart, R.S.L. & Boomsma, D.I. (2010). Childhood and Adolescent Anxiety and Depression: Beyond Heritability. Journal of the American Academy of Child and Adolescent Psychiatry, 49(8), Geus, E.J.C. de (2010). From genotype to EEG endophenotype: a route for post-genomic understanding of complex psychiatric disease? Genome Medicine, 2(63). Jonker, M.A. & Boomsma, D.I. (2010). A frailty model for (interval) censored family survival data, applied to the age at onset of non-physical problems. Lifetime data analysis, 16, Kasper, S., Hajak, G., Wulff, K., Hoogendijk, W.J.G., Montejo, A.L., Smeraldi, E., Rybakowski, J.K., Quera-Salva, M.A., Wirz-Justice, A.M., Picarel-Blanchot, F. & Bayle, F.J. (2010). Efficacy of the Novel Antidepressant Agomelatine on the Circadian Rest-Activity Cycle and Depressive and Anxiety Symptoms in Patients With Major Depressive Disorder: A Randomized, Double- Blind Comparison With Sertraline. Journal of Clinical Psychiatry, 71(2), Katerberg, H., Cath, D.C., Denys, D.A.J.P., Heutink, P., Polman, A., Nieuwerburgh, F.C.W. van, Deforce, D.L.D., Bochdanovits, Z., Balkom, A.J.L.M. van & Boer, J.A. den (2010). The Role of the COMT Val(158)Met Polymorphism in the Phenotypic Expression of Obsessive- Compulsive Disorder. American Journal of Medical Genetics, 153B(1), Klumpers, U.M.H., Veltman, D.J., Drent, M.L., Boellaard, R., Comans, E.F.I., Meynen, G., Lammertsma, A.A. & Hoogendijk, W.J.G. (2010). Reduced parahippocampal and lateral temporal GABA(A)-[C-11]flumazenil binding in major depression: preliminary results. European Journal of Nuclear Medicine and Molecular Imaging, 37(3), Lamb, D.J., Middeldorp, C.M., Beijsterveldt, C.E.M. van, Bartels, M., Aa, N. van der, Polderman, J.C. & Boomsma, D.I. (2010). Heritability of anxious-depressive and withdrawn behavior: Agerelated changes during adolescence. Journal of the American Academy of Child and Adolescent Psychiatry, 49(3), Lango Allen, H., Estrada, K., Lettre, G., Berndt, S.I., Weedon, M.N., Rivadeneira, F., Hottenga, J.J., Geus, E.J.C. de, Willemsen, G., Ommen, G.J.B van, Martin, N.G., Montgomery, GW, Boomsma, D.I., Penninx, B.W.J.H., Duijn, C.M. van, Peltonen, L., Visscher, P.M., Uitterlinden, A.G., Abecasis, G.R., Stefansson, H., Frayling, T.M. & Hirschhorn, J.N. (2010). Hundreds of variants clustered in genomic loci and biological pathways affect human height. Nature, 467(7317), Leeuwen, N. van, Caprio, M., Blaya, C., Fumeron, F., Sartorato, P., Ronconi, V., Giacchetti, G., Mantero, F., Fernandes-Rosa, F.L., Simian, C., Peyrard, S., Zitman, F.G., Penninx, B.W.J.H., Kloet, E.R. de, Azizi, M., Jeunemaitre, X., DeRijk, R.H. & Zennaro, M.C. (2010). The Functional c.-2g > C Variant of the Mineralocorticoid Receptor Modulates Blood Pressure, Renin, and Aldosterone Levels. Hypertension, 56(5), 995. Licht, C.M.M., Vreeburg, S.A., Reedt Dortland, A.K.B. van, Giltay, E.J., Hoogendijk, W.J.G., DeRijk, R.H., Vogelzangs, N., Zitman, F.G., Geus, E.J.C. de & Penninx, B.W.J.H. (2010). Increased sympathetic and decreased parasympathetic activity rather than changes in hypothalamic-pituitary-adrenal axis activity is associated with metabolic abnormalities. Journal of Clinical Endocrinology and Metabolism, 95(5), Licht, C.M.M., Geus, E.J.C. de, Dyck, R. van & Penninx, B.W.J.H. (2010). Longitudinal evidence for unfavorable effects of antidepressants on heart rate variability. Biological Psychiatry, 68(9), Ligthart, R.S.L., Penninx, B.W.J.H., Nijholt, D.R., Distel, M.A., Geus, E.J.C. de, Willemsen, G., Smit, J.H. & Boomsma, D.I. (2010). Migraine symptomatology and major depressive disorder. Cephalalgia, 30(9), Lucassen, P.J., Meerlo, P., Naylor, A.S., Dam, A.M.W. van, Dayer, A.G., Fuchs, E., Oomen, C.A. & Czeh, B. (2010). Regulation of adult neurogenesis by stress, sleep disruption, exercise and inflammation: Implications for depression and antidepressant action. European Neuropsychopharmacology, 20(1),

94 Mill, J.G. van, Hoogendijk, W.J.G., Vogelzangs, N., Dyck, R. van & Penninx, B.W.J.H. (2010). Insomnia and Sleep Duration in a Large Cohort of Patients With Major Depressive Disorder and Anxiety Disorders. Journal of Clinical Psychiatry, 71(3), Minica, C.C., Boomsma, D.I., Sluis, S. van der & Dolan, C.V. (2010). Genetic association in multivariate phenotypic data: Power in five models. Twin Research and Human Genetics, 13(6), Naukkarinen, J., Surakka, I., Pietilainen, K.H., Rissanen, A, Salomaa, V., Ripatti, S., Yki-Jarvinen, H., Duijn, C.M. van, Wichmann, H.-E., Kaprio, J., Taskinen, M.R., Boomsma, D.I. & Peltonen, L. (2010). Use of genome-wide expression data to mine the "gray zone" of GWA studies leads to novel candidate obesity genes. PLoS ONE, 6(6), e Padmanabhan, S., Melander, O., Johnson, T., Blasio, A.M. 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102 Shen, L., Kim, S., Risacher, S.L., Nho, K., Swaminathan, S., West, J.D., Foroud, T., Pankratz, N., Moore, J.H., Sloan, C.D., Huentelman, M.J., Craig, D.W., DeChairo, B.M., Potkin, S.G., Jack, C.R., Weiner, M.W., Saykin, A.J. & Fox, N.C. (2010). Whole genome association study of brain-wide imaging phenotypes for identifying quantitative trait loci in MCI and AD: A study of the ADNI cohort. Neuroimage, 53(3), Sikkes, S.A.M., Berg, M.T. van den, Knol, D.L., Klerk, E.S.M. de, Scheltens, P., Uitdehaag, B.M.J., Klein, M. & Pijnenburg, Y.A.L. (2010). How useful Is the IQCODE for discriminating between Alzheimer's disease, mild cognitive impairment and subjective memory complaints? Dementia and Geriatric Cognitive Disorders, 30(5), Simon, B., Schmidt, S., Lukas, C., Gieseke, J., Traber, F., Knol, D.L., Willinek, W.A., Geurts, J.J.G., Schild, H.H., Barkhof, F. & Wattjes, M.P. (2010). Improved in vivo detection of cortical lesions in multiple sclerosis using double inversion recovery MR imaging at 3 Tesla. European Radiology, 20(7), Slats, D., Spies, P.E., Sjogren, M.J.C., Visser, P.J., Verbeek, M.M., Rikkert, M.G.M.O. & Kehoe, P.G. (2010). CSF biomarker utilisation and ethical considerations of biomarker assisted diagnosis and research in dementia: perspectives from within the European Alzheimer's Disease Consortium (EADC). Journal of Neurology, Neurosurgery and Psychiatry, 81(1), Sluimer, J.D., Bouwman, F.H., Vrenken, H., Blankenstein, M.A., Barkhof, F., Flier, W.M. van der & Scheltens, P. (2010). Whole-brain atrophy rate and CSF biomarker levels in MCI and AD: A longitudinal study. Neurobiology of Aging, 31(5), Smeets, F., Vuurman, E.F., Boxtel, M.P.J. van, Burgmans, S., Gronenschild, E.H., Uylings, H.B.M. & Jolles, J. (2010). Aging does not affect gray matter asymmetry. Psychology & Aging, 25(3), Staekenborg, S.S., Su, T., Straaten, E.C.W. van, Lane, R., Scheltens, P., Barkhof, F. & Flier, W.M. van der (2010). Behavioural and psychological symptoms in vascular dementia; differences between small- and large-vessel disease. Journal of Neurology, Neurosurgery and Psychiatry, 81(5), Staekenborg, S.S., Waal, H. de, Admiraal-Behloul, F., Barkhof, F., Reiber, J.H.C., Scheltens, P., Pijnenburg, Y.A.L., Vrenken, H. & Flier, W.M. van der (2010). Neurological Signs in Relation to White Matter Hyperintensity Volumes in Memory Clinic Patient. Dementia and Geriatric Cognitive Disorders, 29(4), Stam, C.J. (2010). Use of magnetoencephalography (MEG) to study functional brain networks in neurodegenerative disorders. Journal of the Neurological Sciences, 289(1-2), Teodorczuk, A., Firbank, M.J., Pantoni, L., Poggesi, A., Erkinjuntti, T., Wallin, A., Wahlund, L.O., Scheltens, P., Waldemar, G., Schrotter, G., Ferro, J.M., Chabriat, H., Bazner, H., Visser, M., Inzitari, D., O'Brien, J.T. & Ladis, G. (2010). Relationship between baseline white-matter changes and development of late-life depressive symptoms: 3-year results from the LADIS study. Psychological Medicine, 40(4), Teunissen, C.E., Verwey, N.A., Kester, M.I., Uffelen, K. van & Blankenstein, M.A. (2010). Standardization of assay procedures for analysis of the CSF biomarkers amyloid β((1-42)), tau, and phosphorylated tau in Alzheimer's disease: report of an International workshop. International Journal of Alzheimer's Disease, 2010(635053). Tolboom, N., Koedam, E.L.G.E., Schott, J.M., Yaqub, M.M., Blankenstein, M.A., Barkhof, F., Pijnenburg, Y.A.L., Lammertsma, A.A., Scheltens, P. & Berckel, B.N.M. van (2010). Dementia Mimicking Alzheimer's Disease Owing to a Tau Mutation: CSF and PET Findings. Alzheimer Disease & Associated Disorders, 24(3), Tolboom, N., Flier, W.M. van der, Boverhoff, J., Yaqub, M.M., Wattjes, M.P., Raijmakers, P.G.H.M., Barkhof, F., Scheltens, P., Herholz, K., Lammertsma, A.A. & Berckel, B.N.M. van (2010). Molecular imaging in the diagnosis of Alzheimer's disease: visual assessment of [C-11]PIB and [F-18]FDDNP PET images. Journal of Neurology, Neurosurgery and Psychiatry, 81(8), Torkildsen, O., Stansberg, C., Angelskar, S.M., Kooi, E.J., Geurts, J.J.G., Valk, P. van der, Myhr, K.M., Steen, V.M. & Bo, L. (2010). Upregulation of Immunoglobulin-related Genes in Cortical Sections from Multiple Sclerosis Patients. Brain Pathology, 20(4), Trompet, S., Vliet, P. van, Craen, A.J. de, Jolles, J., Buckley, B.M., Gronenschild, E.H., Murphy, M.B., Ford, I., Macfarlane, P.W., Sattar, N., Packard, C.J., Stott, D.J., Shepherd, J., Bollen, E.L., Blauw, G.J., Jukema, J.W. & Westendorp, R.G. (2010). Pravastatin and cognitive function in the elderly. Results of the PROSPER study. Journal of Neurology, 257(1), Tsolaki, M., Papaliagkas, V., Anogianakis, G., Bernabei, R., Emre, M., Frolich, L., Visser, P.J., Michel, J. P., Pirttila, T., Rikkert, M.O., Soininen, H., Sobow, T., Vellas, B., Verhey, F. & Winblad, B. (2010). Consensus Statement on Dementia Education and Training in Europe. Journal of Nutrition Health & Aging, 14(2),

103 Turner, P.L., Someren, E.J.W. van & Mainster, M.A. (2010). The role of environmental light in sleep and health: Effects of ocular aging and cataract surgery. Sleep Medicine Reviews, 14(4), Uylings, H.B.M., Sanz-Arigita, E.J., Vos, K., Pool, C.W., Evers, P. & Rajkowska, G. (2010). 3-D Cytoarchitectonic parcellation of human orbitofrontal cortex Correlation with postmortem MRI. Psychiatry Research. Neuroimaging, 183(1), Verdelho, A., Madureira, S., Moleiro, C., Ferro, J.M., Santos, C.O., Erkinjuntti, T., Pantoni, L., Fazekas, F., Visser, M., Waldemar, G., Wallin, A., Hennerici, M. & Inzitari, D. (2010). White matter changes and diabetes predict cognitive decline in the elderly The LADIS Study. Neurology, 75(2), Verwey, N.A., Kester, M.I., Flier, W.M. van der, Veerhuis, R., Berkhof, H., Twaalfhoven, H.A.M., Blankenstein, M.A., Scheltens, P. & Pijnenburg, Y.A.L. (2010). Additional Value of CSF Amyloid-beta(40) Levels in the Differentiation between FTLD and Control Subjects. Journal of Alzheimer's Disease, 20(2), Vounou, M., Nichols, T.E., Montana, G. & Fox, N.C. (2010). Discovering genetic associations with high-dimensional neuroimaging phenotypes: A sparse reduced-rank regression approach. Neuroimage, 53(3), Vrenken, H., Seewann, A.M., Knol, D.L., Polman, C.H., Barkhof, F. & Geurts, J.J.G. (2010). Diffusely Abnormal White Matter in Progressive Multiple Sclerosis: In Vivo Quantitative MR Imaging Characterization and Comparison between Disease Types. American Journal of Neuroradiology, 31(3), Werd, H.J.J.M. van de, Rajkowska, G., Evers, P. & Uylings, H.B.M. (2010). Cytoarchitectonic and chemoarchitectonic characterization of the prefrontal cortical areas in the mouse. Brain Structure & Function, 214(4), Witte, M.E., Geurts, J.J.G., Vries, H.E. de, Valk, P. van der & Horssen, J. van (2010). Mitochondrial dysfunction: A potential link between neuroinflammation and neurodegeneration? Mitochondrion, 10(5), Worthington, V., Killestein, J., Eikelenboom, M.J., Teunissen, C.E., Barkhof, F., Polman, C.H., Uitdehaag, B.M.J. & Petzold, A.F.S. (2010). Normal CSF ferritin levels in MS suggest against etiologic role of chronic venous insufficiency. Neurology, 75(18), Yaqub, M.M., Tolboom, N., Berckel, B.N.M. van, Scheltens, P., Lammertsma, A.A. & Boellaard, R. (2010). Simplified parametric methods for [F-18]FDDNP studies. Neuroimage, 49(1), Zarei, M., Patenaude, B., Damoiseaux, J.S., Morgese, C., Smith, S., Matthews, P.M., Barkhof, F., Rombouts, S., Sanz-Arigita, E.J. & Jenkinson, M. (2010). Combining shape and connectivity analysis: An MRI study of thalamic degeneration in Alzheimer's disease. Neuroimage, 49(1), 1-8. Scientific papers non-refereed Boss, H.M., Berg-Vos, R.M. van den, Scheltens, P. & Weinstein, H.C. (2010). Stand van zaken. Vasculaire cognitieve beperking. Nederlands Tijdschrift voor Geneeskunde, 154, A1907. Scientific publication (books, monographs, book chapters, proceedings) Books/monographs Bars, R., Galay-Burgos, M., Ravenzwaaij, B., Vrijhof, H. & Vies, S.M. van der (2010). Omics (Eco)Toxicology: Case Studies and Risk Assessment. Brussels, Belgium: ECETOC-AISBL. Book chapter Groenewegen, H.J. & Uylings, H.B.M. (2010). Organization of prefrontal-striatal connections. In H. Steiner & K.Y. Tseng (Eds.), Handbook of Basal Ganglia Structure and Function: A Decade of Progress (Handbook of Behavioral Neuroscience, 20) (pp ). San Diego/Amsterdam: Academic Press/Elsevier. Voorn, P. (2010). Projections from Pallidum to Striatum. In H. Steiner & K.Y. Tseng (Eds.), Handbook of Basal Ganglia Structure and Function: A Decade of Progress (Handbook of Behavioral Neuroscience, 20) (pp ). San Diego/Amsterdam: Academic Press/Elsevier. Witter, M.P. (2010). Connectivity of the Hippocampus. In V. Cutsuridis, B. Graham, S. Cobb & I. Vida (Eds.), Hippocampal microcircuits (Springer Series in Computational Neuroscience, 5) (pp. 5-26). Springer. 101

104 Professional publications Burgmans, S., Jolles, J. & Uylings, H.B.M. (2010). Cognitieve veroudering en veranderingen in de structuur en functie van de hersenen: een nieuw perspectief. Neuropraxis, 14(3), Groenewegen, H.J. & Uylings, H.B.M. (2010). Het enigma van de nucleus subthalamicus: Implicaties voor neurlogische en psychiatrische ziektebeelden. Neuropraxis, 14(6). Lanciego, J.L. & Wouterlood, F.G. (2010). Proceedings of the workshop "Neuroanatomical Tracing and Systems Neuroscience: the State of the Art. In J..L. Lanciego (Ed.), 7th FENS Meeting Vol Journal of Neuroscience Methods (pp ). Elsevier. Rozemuller, A.J.M. (2010). Over hoofd- en breinzaken (2010, juni 18). Amsterdam: Vrije Universiteit. Brain Disease Mechanisms: WHITE MATTER DISEASE Theses VU/VUmc PhD-student at VU (A) Elskamp, I.J. van den (2010, juni 03). Powerfull outcome measures in MS. VU Vrije Universiteit. Prom./coprom.: prof. dr. F. Barkhof & prof. dr. B.M.J. Uitdehaag. Kragt, J.J. (2010, december 17). Measuring disease progression in MS: do 'patients and physicians' perspectives match. VU Vrije Universiteit. Prom./coprom.: prof. dr. B.M.J. Uitdehaag & prof. dr. C.H. Polman. Moraal, B. (2010, februari 12). 3D and subtraction MR imaging in Multiple Sclerosis: improved detection of spatiotemporal disease activity. VU Vrije Universiteit. Prom./coprom.: prof. dr. F. Barkhof & prof. dr. C.H. Polman. Roosendaal, S.D. (2010, april 15). Whiter shades of grey: clinical relevance of grey matter abnormalities as visualized by MRI in multiple sclerosis. VU Vrije Universiteit. Prom./coprom.: prof. dr. F. Barkhof. Vereyken, E.J.F. (2010, november 04). The role of differently activated macrophages on axonal damage during multiple sclerosis. VU Vrije Universiteit. Prom./coprom.: prof. dr. C.D. Dijkstra. Voorn, J.P. van der (2010, oktober 21). White matter disorders: MRI-pathology correlations. VU Vrije Universiteit. Prom./coprom.: prof. dr. M.S. van der Knaap & prof. dr. F. Barkhof. Scientific papers refereed Amor, S., Puentes, F., Baker, D. & Valk, P. van der (2010). Inflammation in neurodegenerative diseases. Immunology, 129(2), Amor, S. (2010). Vitamin D Links Genetic and Environmental Risk Factors in Multiple Sclerosis. CNS & Neurological Disorders. Drug Targets, 9(5), Anand, G., Maheshwari, N., Roberts, D., Padeniya, A., Hamilton-Ayers, M., Knaap, M.S. van der, Fratter, C. & Jayawant, S. (2010). X-linked hereditary motor sensory neuropathy (type 1) presenting with a stroke-like episode. Developmental Medicine and Child Neurology, 52(7), Antonicka, H., Ostergaard, E., Sasarman, F., Weraarpachai, W., Wibrand, F., Pedersen, A.M.B., Rodenburg, R.J., Knaap, M.S. van der, Smeitink, J.A.M., Chrzanowska-Lightowlers, ZM & Shoubridge, E.A. (2010). Mutations in C12orf65 in Patients with Encephalomyopathy and a Mitochondrial Translation Defect. American Journal of Human Genetics, 87(1), Ardon, O., Filippo, C.A. di San, Salomons, G.S. & Longo, N. (2010). Creatine Transporter Deficiency in Two Half-Brothers. American Journal of Medical Genetics, 152A(8), Axtell, R.C., Jong, B.A. de, Boniface, K., Voort, L.F. van der, Bhat, R., Sarno, P. De, Naves, R., Han, M., Zhong, F., Castellanos, J.G., Mair, R., Christakos, A., Kolkowitz, I., Katz, L., Killestein, J., Polman, C.H., Malefyt, R.D., Steinman, L. & Raman, C. (2010). T helper type 1 and 17 cells determine efficacy of interferon-beta in multiple sclerosis and experimental encephalomyelitis. Nature Medicine, 16(4), 406-U21. Barkhof, F. (2010). "Benign'' and "normal appearing'': it's in the eye of the beholder. Journal of Neurology, Neurosurgery and Psychiatry, 81(1), 4-4. Barkhof, F., Hulst, H.E., Drulovic, J., Uitdehaag, B.M.J., Matsuda, K. & Landin, R. (2010). Ibudilast in relapsing-remitting multiple sclerosis A neuroprotectant? Neurology, 74(13), Berfelo, F.J., Kersbergen, K.J., Ommen, C.H. van, Govaert, P., Straaten, H.L.M. van, Poll-The, B., Wezel-Meijler, G., Vermeulen, R.J., Groenendaal, F., Vries, L.S. de & Haan, T.R. (2010). Neonatal Cerebral Sinovenous Thrombosis From Symptom to Outcome. Stroke, 41(7),

105 Berger, J.R., Centonze, D., Comi, G., Confavreux, C., Cutter, G., Giovannoni, G., Gold, R., Hartung, H.P., Lublin, F., Miravalle, A., Montalban, X., O'Connor, P., Olsson, T., Polman, C.H., Stuve, O., Wolinsky, J.S. & Ziemssen, T. (2010). Considerations on Discontinuing Natalizumab for the Treatment of Multiple Sclerosis. Annals of Neurology, 68(3), Biancheri, R., Zara, F., Bruno, C., Gazzerro, E., Rossi, A., Knaap, M.S. van der & Minetti, C. (2010). Hypomyelination and Congenital Cataract GeneReviews. Bie, H.M.A. de, Boersma, M., Wattjes, M.P., Adriaanse, S., Vermeulen, R.J., Oostrom, K.J., Huisman, J., Veltman, D.J. & Delemarre-van de Waal, H.A. (2010). Preparing children with a mock scanner training protocol results in high quality structural and functional MRI scans. European Journal of Pediatrics, 169(9), Bok, L.A., Been, J.V., Struijs, E.A., Jakobs, C., Rijper, E.A.M. & Willemsen, M.A. (2010). Antenatal treatment in two Dutch families with pyridoxine-dependent seizures. European Journal of Pediatrics, 169(3), Bok, L.A., Maurits, N.M., Willemsen, M.A., Jakobs, C., Teune, L.K., Poll-The, B., Coo, I.F. de, Toet, M.C., Hagebeuk, E.E., Brouwer, O.F., Hoeven, J.H. van der & Sival, D.A. (2010). The EEG response to pyridoxine-iv neither identifies nor excludes pyridoxine-dependent epilepsy. Epilepsia, 51(12), Bosma, L.V.A.E., Kragt, J.J., Brieva, L., Khaleeli, Z., Montalban, X., Polman, C.H., Thompson, A.J., Tintore, M. & Uitdehaag, B.M.J. (2010). Progression on the Multiple Sclerosis Functional Composite in multiple sclerosis: what is the optimal cut-off for the three components? Multiple Sclerosis, 16(7), Bouts, A.H., Roofthooft, M.T.R., Salomons, G.S. & Davin, J.C. (2010). CD46-associated atypical hemolytic uremic syndrome with uncommon course caused by cblc deficiency. Pediatric Nephrology, 25(12), Bugiani, M., Boor, I., Powers, J.M., Scheper, G.C. & Knaap, M.S. van der (2010). Leukoencephalopathy With Vanishing White Matter: A Review. Journal of Neuropathology and Experimental Neurology, 69(10), Coebergh, J.A.F., Roosendaal, S.D., Polman, C.H., Geurts, J.J.G. & Woerkom, T.C.A.M. van (2010). Acute severe memory impairment as a presenting symptom of multiple sclerosis: a clinical case study with 3D double inversion recovery MR imaging. Multiple Sclerosis, 16(12), Cohen, J.A., Barkhof, F., Comi, G., Hartung, H.P., Khatri, B.O., Montalban, X., Pelletier, J., Capra, R., Gallo, P., Izquierdo, G., Tiel-Wilck, K., Vera, A. de, Jin, J., Stites, T., Wu, S., Aradhye, S. & Kappos, L. (2010). Oral Fingolimod or Intramuscular Interferon for Relapsing Multiple Sclerosis. New England Journal of Medicine, 362(5), D'hooghe, M.B., Nagels, G. & Uitdehaag, B.M.J. (2010). Long-term effects of childbirth in MS. Journal of Neurology, Neurosurgery and Psychiatry, 81(1), Doorn, R.P. van, Horssen, J. van, Verzijl, D., Witte, M.E., Ronken, E., Hof, B.V., Lakeman, K., Dijkstra, C.D., Valk, P. van der, Reijerkerk, A., Alewijnse, A.E., Peters, S.L.M. & Vries, H.E. de (2010). Sphingosine 1-Phosphate Receptor 1 and 3 Are Upregulated in Multiple Sclerosis Lesions. Glia, 58(12), Elskamp, I.J. van den, Boden, B.H., Dattola, V., Knol, D.L., Filippi, M., Kappos, L., Fazekas, F., Wagner, K., Pohl, C., Sandbrink, R., Polman, C.H., Uitdehaag, B.M.J. & Barkhof, F. (2010). Cerebral atrophy as outcome measure in short-term phase 2 clinical trials in multiple sclerosis. Neuroradiology, 52(10), Elskamp, I.J. van den, Knol, D.L., Vrenken, H., Karas, G., Meijerman, A., Filippi, M., Kappos, L., Fazekas, F., Wagner, K., Pohl, C., Sandbrink, R., Polman, C.H., Uitdehaag, B.M.J. & Barkhof, F. (2010). Lesional magnetization transfer ratio: a feasible outcome for remyelinating treatment trials in multiple sclerosis. Multiple Sclerosis, 16(6), Engberink, R.D. Oude, Blezer, E.L.A., Dijkstra, C.D., Pol, S.M.A. van der, Toorn, A. van der & Vries, H.E. de (2010). Dynamics and fate of USPIO in the central nervous system in experimental autoimmune encephalomyelitis. NMR in Biomedicine, 23(9), Engberink, R.D. Oude, Pol, S.M.A. van der, Walczak, P., Toorn, A. van der, Viergever, M.A., Dijkstra, C.D., Bulte, J.W.M., Vries, H.E. de & Blezer, E.L.A. (2010). Magnetic Resonance Imaging of Monocytes Labeled with Ultrasmall Superparamagnetic Particles of Iron Oxide Using Magnetoelectroporation in an Animal Model of Multiple Sclerosis. Molecular Imaging, 9(5), Engelke, U.F.H., Zijlstra, F.S.M., Mochel, F., Valayannopoulos, V., Rabier, D., Kluijtmans, L.A.J., Perl, A., Verhoeven-Duif, N.M., Lonlay, P. de, Wamelink, M.M.C., Jakobs, C., Morava, E. & Wevers, R.A. (2010). Mitochondrial involvement and erythronic acid as a novel biomarker in transaldolase deficiency. Biochimica et Biophysica Acta. Molecular Basis of Disease, 1802(11),

106 Escalera, G.I., Ferrer, I., Marina, L.C., Sala, P.R., Salomons, G.S., Jakobs, C. & Perez-Cerda, C. (2010). Succinic semialdehyde dehydrogenase deficiency: Decrease in 4-OH-butyric acid levels with low doses of vigabatrin. Anales de Pediatria, 72(2), Filippi, M., Rocca, M.A., Benedict, R.H.B., DeLuca, J., Geurts, J.J.G., Rombouts, S.A.R.B., Ron, M. & Comi, G. (2010). The contribution of MRI in assessing cognitive impairment in multiple sclerosis. Neurology, 75(23), Geurts, J.J.G., Kooi, E.J., Witte, M.E. & Valk, P. van der (2010). Multiple Sclerosis as an "Inside-Out" Disease. Annals of Neurology, 68(5), Geurts, J.J.G. & Horssen, J. van (2010). The brake on neurodegeneration Increased mitochondrial metabolism in the injured MS spinal cord. Neurology, 74(9), Geurts, J.J.G. & Vrenken, H. (2010). Toward understanding cortical lesions in multiple sclerosis. Neurology, 75(14), Geytenbeek, J.J.M., Heim, M.M.J., Vermeulen, R.J. & Oostrom, K.J. (2010). Assessing Comprehension of Spoken Language in Nonspeaking Children with Cerebral Palsy: Application of a Newly Developed Computer-Based Instrument. Augmentative and Alternative Communication, 26(2), Glim, J.E., Vereyken, E.J.F., Heijnen, D.A.M., Garcia Vallejo, J.J. & Dijkstra, C.D. (2010). The Release of Cytokines by Macrophages Is Not Affected by Myelin Ingestion. Glia, 58(16), Grunt, S., Becher, J.G.S.J.S., Schie, P.E.M. van, Ouwerkerk, W.J.R. van, Ahmadi, N. & Vermeulen, R.J. (2010). Preoperative MRI findings and functional outcome after selective dorsal rhizotomy in children with bilateral spasticity. Child's Nervous System, 26(2), Guadagno, J.V. & Polman, C.H. (2010). Personal View A Dutch window into the development of a two tier healthcare system. British Medical Journal, 340, c2330. Hathaway, S.C., Friez, M., Limbo, K., Parker, C., Salomons, G.S., Vockley, J., Wood, T. & Abdul- Rahman, O.A. (2010). X-Linked Creatine Transporter Deficiency Presenting as a Mitochondrial Disorder. Journal of Child Neurology, 25(8), Hojnacki, D., Zamboni, P., Lopez Soriano, A., Galleotti, R., Menegatti, E., Weinstock-Guttman, B., Schirda, C., Magnano, C., Malagoni, A.M., Kennedy, C., Bartolomei, I., Salvi, F. & Zivadinov, R. (2010). Use of neck magnetic resonance venography, Doppler sonography and selective venography for diagnosis of chronic cerebrospinal venous insufficiency: a pilot study in multiple sclerosis patients and healthy controls. International Angiology, 29(2), Horssen, J. van, Drexhage, J.A.R., Flor, T., Gerritsen, W.H., Valk, P. van der & Vries, H.E. de (2010). Nrf2 and DJ1 are consistently upregulated in inflammatory multiple sclerosis lesions. Free Radical Biology and Medicine, 49(8), Jakkula, E., Leppa, V., Sulonen, A.M., Varilo, T., Kallio, S., Kemppinen, A., Purcell, S., Koivisto, K., Tienari, P., Sumelahti, M.L., Elovaara, I., Pirttila, T., Reunanen, M., Aromaa, A., Oturai, A.B., Sondergaard, H.B., Harbo, H.F., Mero, I.L., Gabriel, S.B., Mirel, D.B., Hauser, S.L., Kappos, L., Polman, C.H., Jager, P.L. de, Hafler, D.A., Daly, M.J., Palotie, A., Saarela, J. & Peltonen, L. (2010). Genome-wide Association Study in a High-Risk Isolate for Multiple Sclerosis Reveals Associated Variants in STAT3 Gene. American Journal of Human Genetics, 86(2), Jefferson, R.J., Absoud, M., Jain, R., Livingston, J.H., Knaap, M.S. van der & Jayawant, S. (2010). Alexander disease with periventricular calcification: a novel mutation of the GFAP gene. Developmental Medicine and Child Neurology, 52(12), Kappos, L., Radue, E.W., O'Connor, P., Polman, C.H., Hohlfeld, R., Calabresi, P., Selmaj, K., Agoropoulou, C., Leyk, M., Zhang-Auberson, L. & Burtin, P. (2010). A Placebo-Controlled Trial of Oral Fingolimod in Relapsing Multiple Sclerosis. New England Journal of Medicine, 362(5), Ketelslegers, I.A., Neuteboom, R.F., Boon, M., Catsman-Berrevoets, C.E., Hintzen, R.Q., Vermeulen, R.J. & Eikelenboom, M.J. (2010). A comparison of MRI criteria for diagnosing pediatric ADEM and MS. Neurology, 74(18), Ketelslegers, I.A., Catsman-Berrevoets, C.E., Boon, M., Eikelenboom, M.J., Stroink, H., Neuteboom, R.F., Aarsen, F.K., Putte, E.M. van de & Hintzen, R.Q. (2010). Fatigue and depression in children with multiple sclerosis and monophasic variants. European Journal of Paediatric Neurology, 14(4), Khan, O., Filippi, M., Freedman, M.S., Barkhof, F., Dore-Duffy, P., Lassmann, H., Trapp, B., Bar-Or, A., Zak, I., Siegel, M.J. & Lisak, R. (2010). Chronic Cerebrospinal Venous Insufficiency and Multiple Sclerosis. Annals of Neurology, 67(3), Killestein, J., Vennegoor, A., Strijbis, E.M.M., Seewann, A.M., Oosten, B.W. van, Uitdehaag, B.M.J. & Polman, C.H. (2010). Natalizumab Drug Holiday in Multiple Sclerosis: Poorly Tolerated. Annals of Neurology, 68(3), Killestein, J., Meer, M.L. van der, Regelink, J.C., Huijgens, P.C. & Polman, C.H. (2010). Severe Cardiac Failure in A Patient with Multiple Sclerosis Following Low-Dose Mitoxantrone Treatment. Neurology, 74(11),

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109 Petzold, A.F.S., Boer, J.F. de, Schippling, S., Vermersch, P., Kardon, R., Green, A., Calabresi, P.A. & Polman, C.H. (2010). Optical coherence tomography in multiple sclerosis: a systematic review and meta-analysis. Lancet Neurology, 9(9), Polman, C.H., Bertolotto, A., Deisenhammer, F., Giovannoni, G., Hartung, H.P., Hemmer, B., Killestein, J., McFarland, H.F., Oger, J., Pachner, A.R., Petkau, J., Reder, A.T., Reingold, S.C., Schellekens, H. & Sorensen, P.S. (2010). Recommendations for clinical use of data on neutralising antibodies to interferon-beta therapy in multiple sclerosis. Lancet Neurology, 9(7), Polman, C.H. & Rudick, R.A. (2010). The Multiple Sclerosis Functional Composite A clinically meaningful measure of disability. Neurology, 74(17), S8-S15. Poretti, A., Limperopoulos, C., Roulet-Perez, E., Wolf, N.I., Rauscher, C., Prayer, D., Muller, A., Weissert, M., Kotzaeridou, U., Plessis, A.J. Du, Huisman, T.A.G.M. & Boltshauser, E. (2010). Outcome of severe unilateral cerebellar hypoplasia. Developmental Medicine and Child Neurology, 52(8), Radue, E.W., Stuart, W.H., Calabresi, P.A., Confavreux, C., Galetta, S.L., Rudick, R.A., Lublin, F.D., Weinstock-Guttman, B., Wynn, D.R., Fisher, E., Papadopoulou, A., Lynn, F., Panzara, M.A., Sandrock, A.W., Polman, C.H., Zwemmer, J.N.P., Nielsen, J.M. & Kragt, J.J. (2010). Natalizumab plus interferon beta-1a reduces lesion formation in relapsing multiple sclerosis. Journal of the Neurological Sciences, 292(1-2), Rauschenberger, K., Scholer, K., Sass, J.O., Sauer, S., Djuric, Z., Rumig, C., Wolf, N.I., Okun, J.G., Kolker, S., Schwarz, H., Fischer, C., Grziwa, B., Runz, H., Numann, A., Shafqat, N., Kavanagh, K.L., Hammerling, G., Wanders, R.J.A., Shield, J.P.H., Wendel, U., Stern, D., Nawroth, P., Hoffmann, G.F., Bartram, C.R., Arnold, B., Bierhaus, A., Oppermann, U., Steinbeisser, H. & Zschocke, J. (2010). A non-enzymatic function of 17 beta-hydroxysteroid dehydrogenase type 10 is required for mitochondrial integrity and cell survival. Embo Molecular Medicine, 2(2), Reijerkerk, A., Kooij, G., Pol, S.M.A. van der, Leyen, T.A., Lakeman, K., Hof, B Van Het, Vivien, D. & Vries, H.E. de (2010). The NR1 subunit of NMDA receptor regulates monocyte transmigration through the brain endothelial cell barrier. Journal of Neurochemistry, 113(2), Rejdak, K., Leary, S.M., Petzold, A.F.S., Thompson, A.J., Miller, D. H. & Giovannoni, G. (2010). Urinary neopterin and nitric oxide metabolites as markers of interferon beta-1a activity in primary progressive multiple sclerosis. Multiple Sclerosis, 16(9), Richard, E., Carrano, A., Hoozemans, J.J.M., Horssen, J. van, Haastert, E.S. van, Eurelings, L.S., Vries, H.E. de, Thal, D.R., Eikelenboom, P., Gool, W.A. van & Rozemuller, A.J.M. (2010). Characteristics of Dyshoric Capillary Cerebral Amyloid Angiopathy. Journal of Neuropathology and Experimental Neurology, 69(11), Rietberg, M.B., Wegen, E.E.H. van, Uitdehaag, B.M.J., Vet, H.C.W. de & Kwakkel, G. (2010). How reproducible is home-based 24-hour ambulatory monitoring of motor activity in patients with multiple sclerosis? Archives of Physical Medicine and Rehabilitation, 91(10), Rietberg, M.B., Wegen, E.E.H. van & Kwakkel, G. (2010). Measuring fatigue in patients with multiple sclerosis: reproducibility, responsiveness and concurrent validity of three Dutch self-report questionnaires. Disability and Rehabilitation, 32(22), Roosendaal, S.D., Schoonheim, M.M., Hulst, H.E., Sanz-Arigita, E.J., Smith, S.M., Geurts, J.J.G. & Barkhof, F. (2010). Resting state networks change in clinically isolated syndrome. Brain, 133, Roosendaal, S.D., Hulst, H.E., Vrenken, H., Feenstra, H.E.M., Castelijns, J.A., Pouwels, P.J.W., Barkhof, F. & Geurts, J.J.G. (2010). Structural and Functional Hippocampal Changes in Multiple Sclerosis Patients with Intact Memory Function. Radiology, 255(2), Rudick, R.A., O'Connor, P.W., Polman, C.H., Goodman, A.D., Ray, S.S., Griffith, N.M., Jurgensen, S.A., Gorelik, L., Forrestal, F., Sandrock, A.W. & Goelz, S.E. (2010). Assessment of JC Virus DNA in Blood and Urine from Natalizumab-Treated Patients. Annals of Neurology, 68(3), Scheper, G.C., Berkel, C.G.M. van, Leisle, L., Groot, K.E. de, Errami, A., Jentsch, T.J. & Knaap, M.S. van der (2010). Analysis of CLCN2 as Candidate Gene for Megalencephalic Leukoencephalopathy with Subcortical Cysts. Genetic Testing and Molecular Biomarkers, 14(2), Schie, P.E.M. van, Becher, J.G.S.J.S., Dallmeijer, A.J., Barkhof, F., Weissenbruch, M.M. van & Vermeulen, R.J. (2010). Motor testing at 1 year improves the prediction of motor and mental outcome at 2 years after perinatal hypoxic-ischaemic encephalopathy. Developmental Medicine and Child Neurology, 52(1), Schiffmann, R., Fogli, A., Knaap, M.S. van der & Boespflug-Tanguy, O. (2010). Childhood Ataxia with Central Nervous System Hypomyelination/Vanishing White Matter. GeneReviews. 107

110 Schmitt, B., Baumgartner, M., Mills, P.B., Clayton, P.T., Jakobs, C., Keller, E. & Wohlrab, G. (2010). Seizures and paroxysmal events: symptoms pointing to the diagnosis of pyridoxinedependent epilepsy and pyridoxine phosphate oxidase deficiency. Developmental Medicine and Child Neurology, 52(7), e133-e142. Schoonheim, M.M., Geurts, J.J.G. & Barkhof, F. (2010). The limits of functional reorganization in multiple sclerosis. Neurology, 74(16), Sellner, J., Boggild, M., Clanet, M., Hintzen, R.Q., Illes, Z., Montalban, X., Pasquier, R.A. Du, Polman, C.H., Sorensen, P.S. & Hemmer, B. (2010). EFNS guidelines on diagnosis and management of neuromyelitis optica. European Journal of Neurology, 17(8), E61. Shah, S., Kumar, Y., McLean, B., Churchill, A., Stoodley, N., Rankin, J., Rizzu, P., Knaap, M.S. van der & Jardine, P. (2010). A dominantly inherited mutation in collagen IV A1 (COL4A1) causing childhood onset stroke without porencephaly. European Journal of Paediatric Neurology, 14(2), Simon, B., Schmidt, S., Lukas, C., Gieseke, J., Traber, F., Knol, D.L., Willinek, W.A., Geurts, J.J.G., Schild, H.H., Barkhof, F. & Wattjes, M.P. (2010). Improved in vivo detection of cortical lesions in multiple sclerosis using double inversion recovery MR imaging at 3 Tesla. European Radiology, 20(7), Sombekke, M.H., Arteta, D., Wiel, M.A. van de, Crusius, J.B.A., Tejedor, D., Killestein, J., Martinez, A, Pena, A.S., Polman, C.H. & Uitdehaag, B.M.J. (2010). Analysis of multiple candidate genes in association with phenotypes of multiple sclerosis. Multiple Sclerosis, 16(6), Steenweg, M.E., Jakobs, C., Errami, A., Dooren, S.J.M. van, Bartolome, M.T.A., Aerssens, P., Baric, I., Baumann, M., Bonafe, L., Chabrol, B., Clarke, J.T.R., Clayton, P., Coker, M., Cooper, S, Falik- Zaccai, T., Gorman, M., Hahn, A., Hasanoglu, A., King, M.D., Klerk, H.B.C. de, Korman, S.H., Lee, C., Lund, A.M., Mejaski-Bosnjak, V., Pascual-Castroviejo, I., Raadhyaksha, A., Rootwelt, T., Roubertie, A., Ruiz-Falco, M.L., Scalais, E., Schimmel, U., Seijo-Martinez, M., Suri, M., Sykut- Cegielska, J., Trefz, F.K., Uziel, G., Valayannopoulos, V., Vianey-Saban, C., Vlaho, S., Vodopiutz, J., Wajner, M., Walter, J., Walter-Derbort, C., Yapici, Z., Zafeiriou, D.I., Spreeuwenberg, M.D., Celli, J., Dunnen, J.T. den, Knaap, M.S. van der & Salomons, G.S. (2010). An Overview of L-2-Hydroxyglutarate Dehydrogenase Gene (L2HGDH) Variants: A Genotype-Phenotype Study. Human Mutation, 31(4), Steenweg, M.E., Vanderver, A., Blaser, S., Blizzi, A., Koning, T.J. de, Mancini, G.M.S., Wieringen, W.N. van, Barkhof, F. & Wolf, N.I. (2010). Magnetic resonance imaging pattern recognition in hypomyelinating disorders. Brain, 133(10), Stefano, N. De, Giorgio, A., Battaglini, M., Rovaris, M., Sormani, M.P., Barkhof, F., Korteweg, T., Enzinger, C., Fazekas, F., Calabrese, M., Dinacci, D., Tedeschi, G., Gass, A., Montalban, X., Rovira, A., Thompson, A., Comi, G., Miller, D. H. & Filippi, M. (2010). Assessing brain atrophy rates in a large population of untreated multiple sclerosis subtypes. Neurology, 74(23), Strien, N.M. van, Mercier, D., Drukarch, B., Brevé, J.J.P., Poole, S., Binnekade, R., Bol, J.G.J.M., Blits, B., Verhaagen, J. & Dam, A.M.W. van (2010). Anti-inflammatory effect by lentiviralmediated overexpression of IL-10 or IL-1 receptor antagonist in rat glial cells and macrophages. Gene Therapy, 17(5), Struijs, E.A. & Jakobs, C. (2010). Metabolism of lysine in alpha-aminoadipic semialdehyde dehydrogenase-deficient fibroblasts: Evidence for an alternative pathway of pipecolic acid formation. FEBS Letters, 584(1), Tallantyre, E.C., Bo, L., Al-Rawashdeh, O., Owens, T, Polman, C.H., Lowe, J.S. & Evangelou, N. (2010). Clinico-pathological evidence that axonal loss underlies disability in progressive multiple sclerosis. Multiple Sclerosis, 16(4), Tassini, M., Zannolli, R., Buoni, S., Engelke, U., Vivi, A., Valensin, G., Salomons, G.S., Nicola, A. De, Strambi, M., Monti, L., Morava, E., Wevers, R.A. & Hayek, J. (2010). [H-1] Magnetic Resonance Spectroscopy of Urine: Diagnosis of a Guanidinoacetate Methyl Transferase Deficiency Case. Journal of Child Neurology, 25(1), Teunissen, C.E., Petzold, A.F.S., Bennett, J.L., Berven, F.S., Brundin, L., Comabella, M., Franciotta, D., Federiksen, J.L., Fleming, J.O., Furlan, R., Hintzen, R.Q., Hughes, S.G., Johnson, M.H., Krasulova, E., Kuhle, J., Magnone, M.C., Rajda, C., Rejdak, K., Schmidt, H.K., Pesch, V. van, Waubant, E., Wolf, C., Giovannoni, G., Deisenhammer, F., Hegen, H., Hemmer, B. & Tumani, H.T. (2010). A consensus protocol for the standardisation of cerebrospinal fluid collection and biobanking. Laboratoriumsmedizin, 34(1), Teunissen, C.E., Tumani, H.T., Bennett, J.L., Berven, F.S., Brundin, L., Comabella, M., Franciotta, D., Federiksen, J.L., Fleming, J.O., Furlan, R., Hintzen, R.Q., Hughes, S.G., Johnson, M.H., Krasulova, E., Kuhle, J., Magnone, M.C., Petzold, A.F.S., Rajda, C., Rejdak, K., Schmidt, H.K., Pesch, V. van, Waubant, E., Wolf, C., Hemmer, B., Deisenhammer, F. & Giovannoni, G. (2010). Short commentary on 'a consensus protocol for the standardization of cerebrospinal fluid collection and biobanking'. Multiple Sclerosis, 16(2),

111 Torkildsen, O., Stansberg, C., Angelskar, S.M., Kooi, E.J., Geurts, J.J.G., Valk, P. van der, Myhr, K.M., Steen, V.M. & Bo, L. (2010). Upregulation of Immunoglobulin-related Genes in Cortical Sections from Multiple Sclerosis Patients. Brain Pathology, 20(4), Tsuji, M., Aida, N., Obata, T., Tomiyasu, M., Furuya, N., Kurosawa, K., Errami, A., Gibson, K.M., Salomons, G.S., Jakobs, C. & Osaka, H. (2010). A new case of GABA transaminase deficiency facilitated by proton MR spectroscopy. Journal of Inherited Metabolic Disease, 33(1), Vermeulen, R.J., Wilke, M., Horber, V. & Krageloh-Mann, I. (2010). Microcephaly with simplified gyral pattern MRI classification. Neurology, 74(5), Vogt, M.H.J., Kate, J. ten, Drent, R.J.M., Polman, C.H. & Hupperts, R. (2010). Increased osteopontin plasma levels in multiple sclerosis patients correlate with bone-specific markers. Multiple Sclerosis, 16(4), Voort, L.F. van der, Gilli, F., Bertolotto, A., Knol, D.L., Uitdehaag, B.M.J., Polman, C.H. & Killestein, J. (2010). Clinical Effect of Neutralizing Antibodies to Interferon Beta That Persist Long After Cessation of Therapy for Multiple Sclerosis. Archives of Neurology, 67(4), Voort, L.F. van der, Vennegoor, A., Visser, A., Knol, D.L., Uitdehaag, B.M.J., Barkhof, F., Oudejans, C.B.M., Polman, C.H. & Killestein, J. (2010). Spontaneous MxA mrna level predicts relapses in patients with recently diagnosed MS. Neurology, 75(14), Vrenken, H., Seewann, A.M., Knol, D.L., Polman, C.H., Barkhof, F. & Geurts, J.J.G. (2010). Diffusely Abnormal White Matter in Progressive Multiple Sclerosis: In Vivo Quantitative MR Imaging Characterization and Comparison between Disease Types. American Journal of Neuroradiology, 31(3), Wamelink, M.M.C., Gruning, N.M., Jansen, E.E.W., Bluemlein, K., Lehrach, H., Jakobs, C. & Ralser, M. (2010). The difference between rare and exceptionally rare: molecular characterization of ribose 5-phosphate isomerase deficiency. Journal of Molecular Medicine, 88(9), Willemsen, M.A., Verbeek, M.M., Kamsteeg, E.J., Andel, J. de Rijk-van, Aeby, A., Blau, N., Burlina, A., Donati, M.A., Geurtz, B., Grattan-Smith, P.J., Haeussler, M., Hoffmann, G.F., Jung, H., Klerk, J.B. de, Knaap, M.S. van der, Kok, F., Leuzzi, V., Lonlay, P. de, Megarbane, A., Monaghan, H., Renier, W.O., Rondot, P., Ryan, M.M., Seeger, J., Smeitink, J.A., Steenbergen-Spanjers, G.C., Wassmer, E., Weschke, B., Wijburg, F.A., Wilcken, B., Zafeiriou, D.I. & Wevers, R.A. (2010). Tyrosine hydroxylase deficiency: a treatable disorder of brain catecholamine biosynthesis. Brain, 133, Winsen, L.M.L. van, Kragt, J.J., Hoogervorst, E.L.J., Polman, C.H. & Uitdehaag, B.M.J. (2010). Outcome measurement in multiple sclerosis: detection of clinically relevant improvement. Multiple Sclerosis, 16(5), Winsen, L.M.L. van, Polman, C.H., Dijkstra, C.D., Tilders, F.J.H. & Uitdehaag, B.M.J. (2010). Suppressive effect of glucocorticoids on TNF-alpha production is associated with their clinical effect in multiple sclerosis. Multiple Sclerosis, 16(4), Witte, M.E., Geurts, J.J.G., Vries, H.E. de, Valk, P. van der & Horssen, J. van (2010). Mitochondrial dysfunction: A potential link between neuroinflammation and neurodegeneration? Mitochondrion, 10(5), Wolff, A., Koch, M.J., Benzinger, S., Waes, H. van, Wolf, N.I., Boltshauser, E. & Luder, H.U. (2010). Rare dental peculiarities associated with the hypomyelinating leukoencephalopathy 4H syndrome/addh. Pediatric Dentistry, 32(5), Worthington, V., Killestein, J., Eikelenboom, M.J., Teunissen, C.E., Barkhof, F., Polman, C.H., Uitdehaag, B.M.J. & Petzold, A.F.S. (2010). Normal CSF ferritin levels in MS suggest against etiologic role of chronic venous insufficiency. Neurology, 75(18), Yis, U., Scheper, G.C., Uran, N., Unalp, A., Cakmakci, H., Hiz-Kurul, S., Dirik, E. & Knaap, M.S. van der (2010). Two cases with megalencephalic leukoencephalopathy with subcortical cysts and MLC1 mutations in the Turkish population. Turkish Journal of Pediatrics, 52(2), Scientific papers non-refereed Dorhout, M.S.M., Braun, K.P.J., Knaap, M.S. van der & Jansen, F.E. (2010). Uw diagnose? Tijdschrift voor Neurologie & Neurochirurgie, 111(5), Killestein, J. (2010). Tabletten voor multipele sclerose: een nieuwe horizon. Nederlands Tijdschrift voor Geneeskunde, 154, A1856. Laszlo, A., Elpeleg, O., Horvath, K., Jakobs, C., Kobor, J., Gal, A., Barsi, P., Kelemen, A., Saracz, J., Svekus, A., Tegzes, A. & Voros, E. (2010). Clinical, Radiological and Genetic Aspects of Leukodystrophies. Ideggyogyaszati Szemle-Clinical Neuroscience, 63(7-8),

112 Scientific publications (books, monographs, book chapters, proceedings) Book chapter Garcia-Cazorla, A., Wolf, N.I. & Hoffmann, G.F. (2010). Approach to the patient with neurological disease. In G.F. Hoffmann, J. Zschocke & W.L. Nyhan (Eds.), Inherited Metabolic Diseases: A Clinical Approach (pp ). Berlin Heidelberg: Springer Verlag. Geurts, J.J.G. & Hulst, H.E. (2010). MS als chronische aandoening. In Merck Serono MS Lexicon deel 3, MS en Psychologie. Gibson, K.M. & Jakobs, C. (2010). Biochemical Investigations. In G.F. Hoffmann, J. Zschocke & W.L. Nyhan (Eds.), Inherited Metabolic Diseases, A Clinical Approach (pp ). Berlin Heidelberg: Springer Verlag. Knaap, M.S. van der, Bugiani, M., Boor, I., Proud, C.G. & Scheper, G.C. (2010). Vanishing White Matter. In C. Scriver (Ed.), The Online Metabolic and Molecular Bases of Inherited Diseases (OMMBID) (Neurogenetics, Part 28) (pp. chapter-235.1). New York: McGraw-Hill. Kooi, E.J. & Geurts, J.J.G. (2010). Hoofdstuk 8. In Handboek voor Multiple Sclerose: Immunopathologie van multiple sclerose. Polman, C.H. & Geurts, J.J.G. (2010). Multiple Sclerose. In A. Hijdra (Ed.), Neurologie. Reed Business, Reed Elsevier. Wattjes, M.P., Geurts, J.J.G. & Barkhof, F. (2010). Imaging of gray matter lesions in MS. In R.A. Rudick (Ed.), Imaging Measures in Multiple Sclerosis. Wolf, N.I. (2010). Pelizaeus-Merzbacher disease. In K. Kompoliti & L. Verhagen (Eds.), Encyclopedia of Movement Disorders (pp ). Oxford: Academic Press. Wolf, N.I. (2010). Suspected mitochondrial disorders. In G.F. Hoffmann, J. Zschocke & W.L. Nyhan (Eds.), Inherited Metabolic Diseases: A Clinical Approach (pp ). Berlin Heidelberg: Springer Verlag. Professional publications Jakobs, C. (2010). SSIEM reflections : the growing stature of our society. Journal of Inherited Metabolic Disease, 33(6), Affiliated research Theses VU/VUmc PhD-student at VU (A) Vries, A.L.C. de (2010, november 19). Gender Dysphoria in Adolescents: Mental Health and Treatment Evaluation. VU Vrije Universiteit. Prom./coprom.: prof. dr. P.T. Cohen-Kettenis & prof. dr. T.A.H. Doreleijers. Scientific papers refereed Bakker, J. & Brock, O. (2010). Early Oestrogens in Shaping Reproductive Networks: Evidence for a Potential Organisational Role of Oestradiol in Female Brain Development. Journal of Neuroendocrinology, 22(7), Bakker, J., Pierman, S. & Gonzalez-Martinez, D. (2010). Effects of aromatase mutation (ArKO) on the sexual differentiation of kisspeptin neuronal numbers and their activation by same versus opposite sex urinary pheromones. Hormones and Behavior, 57(4-5), Banga, F.R., Huirne, J.A.F., Korsen, T., Homburg, R.R., Hompes, P.G.A. & Lambalk, C.B. (2010). Pituitary sensitizing effect of GnRH antagonists: a mechanism explaining LH escape during IVF? Human Reproduction, 25(6), Berg, M.H. van den, Broeder, E. den, Overbeek, A., Twisk, J.W.R., Schats, R., Leeuwen, F.E. van, Kaspers, G.J.L. & Lambalk, C.B. (2010). Comparison of ovarian function markers in users of hormonal contraceptives during the hormone-free interval and subsequent natural early follicular phases. Human Reproduction, 25(6), Bie, H.M.A. de, Oostrom, K.J. & Waal, H.A. Delemarre-van d (2010). Brain Development, Intelligence and Cognitive Outcome in Children Born Small for Gestational Age. Hormone Research in Paediatrics, 73(1), Brock, O., Douhard, Q., Baum, M.J. & Bakker, J. (2010). Reduced Prepubertal Expression of Progesterone Receptor in the Hypothalamus of Female Aromatase Knockout Mice. Endocrinology, 151(4),

113 Brock, O., Keller, M., Veyrac, A., Douhard, Q. & Bakker, J. (2010). Short Term Treatment with Estradiol Decreases the Rate of Newly Generated Cells in the Subventricular Zone and Main Olfactory Bulb of Adult Female Mice. Neuroscience, 166(2), Bui, H.N., Struijs, E.A., Martens, F., Ronde, W. de, Thienpont, L.M., Kenemans, P., Verhoeven, M.O., Jakobs, C., Dijstelbloem, H.M. & Blankenstein, M.A. (2010). Serum testosterone levels measured by isotope dilution-liquid chromatography-tandem mass spectrometry in postmenopausal women versus those in women who underwent bilateral oophorectomy. Annals of Clinical Biochemistry, 47(3), Bunderen, C.C. van, Nieuwpoort, I.C. van, Schoor, N.M. van, Deeg, D.J.H., Lips, P.T.A.M. & Drent, M.L. (2010). The Association of Serum Insulin-Like Growth Factor-I with Mortality, Cardiovascular Disease, and Cancer in the Elderly: A Population-Based Study. Journal of Clinical Endocrinology and Metabolism, 95(10), Cohen-Kettenis, P.T. (2010). Psychosocial and psychosexual aspects of disorders of sex development. Baillière's Best Practice & Research. Clinical Endocrinology & Metabolism, 24(2), Cohen-Kettenis, P.T. & Pfafflin, F. (2010). The DSM Diagnostic Criteria for Gender Identity Disorder in Adolescents and Adults. Archives of Sexual Behavior, 39(2), Disseldorp, J. van, Lambalk, C.B., Kwee, J., Looman, C.W.N., Eijkemans, M.J.C., Fauser, B.C.J.M. & Broekmans, F.J.M. (2010). Comparison of inter- and intra-cycle variability of anti-mullerian hormone and antral follicle counts. Human Reproduction, 25(1), Graaff, L.C.G., Argente, J., Veenma, D.C.M., Drent, M.L., Uitterlinden, A.G. & Hokken-Koelega, A.C.S. (2010). Prop1, Hesx1, Pou1F1, Lhx3 and Lhx4 Mutation and Deletion Screening and Gh1 P89l and Ivs3+1/+2 Mutation Screening in A Dutch Nationwide Cohort of Patients with Combined Pituitary Hormone Deficiency. Hormone Research in Paediatrics, 73(5), Groeneveld, E., Lambers, M.J., Hoozemans, D.A., Schats, R., Hompes, P.G.A. & Lambalk, C.B. (2010). Blood-borne angiogenic factors and sustained multiple implantation: a comparison of singleton and twin pregnancies. Reproductive Biomedicine Online, 20(6), Haadsma, M.L., Mooij, T.M., Groen, H., Burger, C.W., Lambalk, C.B., Broekmans, F.J.M., Leeuwen, F.E. van, Bouman, K. & Hoek, A. (2010). A reduced size of the ovarian follicle pool is associated with an increased risk of a trisomic pregnancy in IVF-treated women. Human Reproduction, 25(2), Haadsma, M.L., Groen, H., Mooij, T.M., Burger, C.W., Broekmans, F.J.M., Lambalk, C.B., Leeuwen, F.E. van & Hoek, A. (2010). Miscarriage risk for IVF pregnancies in poor responders to ovarian hyperstimulation. Reproductive Biomedicine Online, 20(2), Hendriks, M.L., Valk, P. van der, Lambalk, C.B., Broeckaert, M.A.M., Homburg, R.R. & Hompes, P.G.A. (2010). Extensive tissue damage of bovine ovaries after bipolar ovarian drilling compared to monopolar electrocoagulation or carbon dioxide laser. Fertility and Sterility, 93(3), Hoekstra, C., Willemsen, A.H.M., Beijsterveldt, C.E.M. van, Lambalk, C.B., Montgomery, GW & Boomsma, D.I. (2010). Body Composition, Smoking, and Spontaneous Dizygotic Twinning. Obstetrical and Gynecological Survey, 65(6), Hoekstra, C., Willemsen, G., Beijsterveldt, C.E.M. van, Lambalk, C.B., Montgomery, GW & Boomsma, D.I. (2010). Body composition, smoking, and spontaneous dizygotic twinning. Fertility and Sterility, 93(3), Jakobsdottir, S., Nieuwpoort, I.C. van, Schaap, L.A., Schoor, N.M. van, Lips, P.T.A.M. & Drent, M.L. (2010). Serum insulin-like growth factor-i and body composition in community dwelling older people. Clinical Endocrinology, 73(2), Janse, F., Knauff, E.A.H., Niermeijer, M.F., Eijkemans, M.J.C., Laven, J.S.E., Lambalk, C.B., Fauser, B.C.J.M. & Goverde, A. J. (2010). Similar phenotype characteristics comparing familial and sporadic premature ovarian failure. Menopause, 17(4), Joshi, D., Schoor, N.M. van, Ronde, W. de, Schaap, L.A., Comijs, H., Beekman, A.T.F. & Lips, P.T.A.M. (2010). Low free testosterone levels are associated with prevalence and incidence of depressive symptoms in older men. Clinical Endocrinology, 72(2), Jurgensen, M., Kleinemeier, E., Lux, A., Steensma, T.D., Cohen-Kettenis, P.T., Hiort, O. & Thyen, U. (2010). Psychosexual Development in Children with Disorder of Sex Development (DSD) - Results from the German Clinical Evaluation Study. Journal of Pediatric Endocrinology & Metabolism, 23(6), Keller, M., Pillon, D. & Bakker, J. (2010). Olfactory Systems in Mate Recognition and Sexual Behavior. Vitamins and Hormones, 83, Keller, M., Pawluski, J.L., Brock, O., Douhard, Q. & Bakker, J. (2010). The alpha-fetoprotein knock-out mouse model suggests that parental behavior is sexually differentiated under the influence of prenatal estradiol. Hormones and Behavior, 57(4-5),

114 Ketel, I.J.G., Stehouwer, C.D., Henry, R.M., Serné, E.H., Hompes, P.G.A., Homburg, R.R., Smulders, Y.M. & Lambalk, C.B. (2010). Greater Arterial Stiffness in Polycystic Ovary Syndrome (PCOS) Is an Obesity-But Not a PCOS-Associated Phenomenon. Journal of Clinical Endocrinology and Metabolism, 95(10), Klumpers, U.M.H., Veltman, D.J., Drent, M.L., Boellaard, R., Comans, E.F.I., Meynen, G., Lammertsma, A.A. & Hoogendijk, W.J.G. (2010). z Nagtegaal, J.E. & Gaillard, C.A.J.M. (2010). Impairment of endogenous melatonin rhythm is related to the degree of chronic kidney disease (CREAM study). Nephrology, Dialysis, Transplantation, 25(2), Kuijper, E.A.M., Blankenstein, M.A., Luttikhof, L.J., Roek, S.J.M., Overbeek, A., Hompes, P.G.A., Twisk, J.W.R. & Lambalk, C.B. (2010). Frequency distribution of polymorphisms in the FSH receptor gene in infertility patients of different ethnicity. Reproductive Biomedicine Online, 20(5), Koch, B.C.P., Putten, K. van der, Someren, E.J.W. van, Wielders, J.P.M., Wee, P.M. ter, Nagtegaal, J.E. & Gaillard, C.A.J.M. (2010). Impairment of endogenous melatonin rhythm is related to the degree of chronic kidney disease (CREAM study). Nephrology, Dialysis, Transplantation, 25(2), Lust, J.M., Geuze, R.H., Beek, C. van de, Cohen-Kettenis, P.T., Groothuis, A.G.G. & Bouma, A. (2010). Sex specific effect of prenatal testosterone on language lateralization in children. Neuropsychologia, 48, Menke, L.A., Sas, T.C.J., Visser, M., Kreukels, B.P.C., Stijnen, T., Zandwijken, G.R.J., Keizer-Schrama, S.M.P.F., Otten, B.J., Wit, J.M. & Cohen-Kettenis, P.T. (2010). The effect of the weak androgen oxandrolone on psychological and behavioral characteristics in growth hormone-treated girls with Turner syndrome. Hormones and Behavior, 57(3), Mouzon, J. de, Goossens, V., Bhattacharya, S., Castilla, J.A., Ferraretti, A.P., Korsak, V., Kupka, M., Nygren, K.G., Andersen, A.N. Nyboe & Lambalk, C.B. (2010). Assisted reproductive technology in Europe, 2006: results generated from European registers by ESHRE. Human Reproduction, 25(8), Rotteveel, J., Felius, A., Weissenbruch, M.M. van & Delemarre-van de Waal, H.A. (2010). Insulin Resistance and the Metabolic Syndrome in Obese Children Referred to an Obesity Center. Journal of Pediatric Endocrinology & Metabolism, 23(9), Sas, T.C.J., Ridder, M.A.J. de, Wit, J.M., Rotteveel, J., Oostdijk, W., Reeser, H.M., Otten, B.J. & Keizer- Schrama, S.M.P.F. (2010). Adult Height in Children with Growth Hormone Deficiency: A Randomized, Controlled, Growth Hormone Dose-Response Trial. Hormone Research in Paediatrics, 74(3), Schie, P.E.M. van, Becher, J.G.S.J.S., Dallmeijer, A.J., Barkhof, F., Weissenbruch, M.M. van & Vermeulen, R.J. (2010). Motor testing at 1 year improves the prediction of motor and mental outcome at 2 years after perinatal hypoxic-ischaemic encephalopathy. Developmental Medicine and Child Neurology, 52(1), Seli, E., Vergouw, C.G., Morita, H., Botros, L., Roos, P., Lambalk, C.B., Yamashita, N., Kato, O. & Sakkas, D. (2010). Noninvasive metabolomic profiling as an adjunct to morphology for noninvasive embryo assessment in women undergoing single embryo transfer. Fertility and Sterility, 94(2), Vries, A.L.C. de, Noens, I.L.J., Cohen-Kettenis, P.T., Berckelaer-Onnes, I.A. & Doreleijers, T.A.H. (2010). Autism Spectrum Disorders in Gender Dysphoric Children and Adolescents. Journal of Autism and Developmental Disorders, 40(8), Wallien, M.S.C., Veenstra, R., Kreukels, B.P.C. & Cohen-Kettenis, P.T. (2010). Peer Group Status of Gender Dysphoric Children: A Sociometric Study. Archives of Sexual Behavior, 39(2), Werken, M. van de, Gimenez, M.C., Vries, B. de, Beersma, D.G.M., Someren, E.J.W. van & Gordijn, M.C.M. (2010). Effects of artificial dawn on sleep inertia, skin temperature, and the awakening cortisol response. Journal of Sleep Research, 19(3), Wiegerink, D.J., Stam, H.J., Gorter, J.W., Cohen-Kettenis, P.T. & Roebroeck, M.E. (2010). Development of Romantic Relationships and Sexual Activity in Young Adults With Cerebral Palsy: A Longitudinal Study. Archives of Physical Medicine and Rehabilitation, 91(9), Wiegerink, D.J.H.G., Roebroeck, M.E., Slot, W.M.A. van der, Stam, H.J. & Cohen-Kettenis, P.T. (2010). Importance of peers and dating in the development of romantic relationships and sexual activity of young adults with cerebral palsy. Developmental Medicine and Child Neurology, 52(6), Woerdeman, J., Kaufman, J.M. & Ronde, W. de (2010). In young men, a moderate inhibition of testosterone synthesis capacity is only partly compensated by increased activity of the pituitary and the hypothalamus. Clinical Endocrinology, 72(1),

115 Appendix 4: Indicators of esteem Awards (no grants) Investigator Name Award Granted by Program Knaap MS van Gesellschaft für Peter-Emil-Becker Award der Neuropädiatrie White Matter Disease Kranendijk M Vereniging tot bevordering in het Nederlandse taalgebied (ESN) Wadman en Van Gennip prijs ( onderzoek Erfelijke 1250,--), Stofwisselingsziekten White Matter Disease Polman CH Winklermedaille 2010 Someren EJW van Someren EJW van Wit H de Witte S NeuroSIPE project thermoregulation and vigilance The role of sleep in children: opportunities for performance improvement The Robert Fuelgen Prize Fysica 2010 Young Speaker Award Nederl. Vereniging voor Neurologie STW NWO National Initiative Brain and Cognition Fonds Economische Structuurversterking Society of Histochemistry Ned. Natuurkundigen Vereniging White Matter Disease Attention & Cognition Attention & Cognition Systems Biology of the Synapse Photonics & Life Cell Imaging Invited lectures Investigator Congress, title lecture Date Program Arwert LI Cognitive impairment in GH deficiency 24/09/ 2010 Affliated Research Bartels M Symposium Positive Psychology. Wat liggen de biologische grenzen van positief functioneren? [What are the 23/09/2010 Anxiety & Depression Biological Boundaries of Positive Functioning?] Analysing the functional properties of Beek JHGM the creatine kinase system with Integrative Analysis & 09/07/2010 van multiscale sloppy modeling ISMB2010 Modeling Student Council Symposium, Boston USA. Beek JHGM van Berendse HW Berendse HW Berendse HW Berendse HW Berendse HW Seminar on Computational modelling of intracellular metabolic networks & flux measurements at Seminar Series Physics and Medical Technology, VUmc, Amsterdam 7th International Congress on Mental Dysfunctions and Other Non-Motor Features in Parkinson s Disease, Barcelona (Spain), Motor and nonmotor correlates of olfactory dysfunction in Parkinson s disease 2nd World Parkinson Congress, Glasgow (UK), Olfactory impairment and other pre-motor symptoms in Parkinson s disease 10th Triennial Meeting of the International Basal Ganglia Society, Long Branch NJ (USA), Catching a new smell in Parkinson s disease MEG at the VUmc: the Past, the Present and the Future, Amsterdam (NL), Resting-state functional connectivity in Parkinson s disease: more is less? Eerste Congres Anosmie Vereniging Nederland, Hilversum (NL), Reuk- en smaakstoornissen vanuit het perspectief van de neuroloog 08/11/2010 Integrative Analysis & Modeling 9-12/12/ /09-01/10/ /06/ /05/ /09/

116 Boomsma DI Boomsma DI Boomsma DI Boomsma DI Boomsma DI Boomsma DI Cohen- Kettenis P Cohen- Kettenis P Cohen- Kettenis P Cohen- Kettenis P Cover KS Dam AMW van Dam AMW van Dijkstra CD Drent ML Drent ML Drukarch B Ent D van t Flier WM van der Flier WM van der Flier WM van der Foncke EMJ Foncke EMJ NIMH, USA: Netherlands Twin Register: Longitudinal genetics studies across the life span Int. Society Twin Studies, South Korea (key note lecture): A twin year in review: behavior and psychiatry Int. NGFNplus-MooDS-Symposium, Neuropsychiatric Disorders: From Gene to Complex Brain Function, Bonn: Twin and GWA studies of depression Hoftorenlezing, Den Haag: Genetisch onderzoek naar complexe eigenschappen XiX Journees Internationales de Psychologie differentielle, Marseille: Twin studies: past, present and future Epidemiological Longitudinal Studies in Europe (CELSE 2010), Paphos, Cyprus: Genetic influences on behavioural development over the life-course 2010 Annual Meeting of the British Endocrine Society; Manchester - Dilemmas in managing gender identity problems in adolescents and adults: Psychological Issues 2010 Annual Meeting of the Pediatric Academic Societies, Vancouver- GnRH analogues: Why, for whom, when, follow-up data 7th German Task Force Meeting on Children and Adolescents with Gender Identity Disorder. Hamburg - Lessons learned: Pros and cons about the treatment of children with puberty delaying hormones VUmc Wetenschapsdag. Amsterdam - Over zijn zijn en haar zijn: 25 jaar genderonderzoek. Lorentz Workshop: New Directions in Modern Cosmology Microglia symposium, Amsterdam, The Netherlands, Title: Microgliosis in the anterior olfactory nucleus of Parkinson and Alzheimer patients Transglutaminases in Human Disease Processes Gordon Research Conference, Davidson, USA. Titel: Local tissue Transglutaminase activity directs experimental Multiple Sclerosis pathology. ECTRIMS, Gothenborg, Sweden. Keynote lecture: Innate Immunity in MS KIMS in een breed perspectief, de toegevoegde waarde van een grote (internationale) database Evidence based groeihormoonbehandeling, feiten en fictie FENS satellite symposium alphasynuclein pathology in Parkinson patients and models. Title: early pathways in alpha-synuclein aggregation NCA, Brain Imagnig Seminar: VBM and DTI in a sample of identical twins selected for the presence or absence of attention problem ISMRM: Clinical needs & technical solutions in Alzheimer s disease: structural and functional imaging V&VN: Zorgen om dementie: Visie van het Alzheimercentrum Vumc Diabetes symposium: Clinical evaluation of cognitive dysfunction and dementia ParkinsonNet Jaarcongres, Videocasuistiek Landelijke aiosdag Specialist Ouderengeneeskunde 05/05/2010 Anxiety & Depression 06/06/2010 Anxiety & Depression 25/06/2010 Anxiety & Depression 08/12/2010 Anxiety & Depression 25/08/2010 Attention & Cognition 15/10/2010 Attention & Cognition March 2010 Affliated Research May 2010 Affliated Research June 2010 Affliated Research March 2010 Affliated Research 27/09-01/10/2010 Brain Imaging 17/03/ /07/2010 White Matter Disease 13-16/10/2010 White Matter Disease 29/06/2010 Affliated Research 08/10/2010 Affliated Research 02/07/ /02/2010 Brain Imaging 24/05/ /04-/ /01/ /11/ /11/

117 Foncke EMJ Garcia Vallejo JJ Garcia Vallejo JJ Geeven G Geeven G Geurts JJG Geurts JJG Geurts JJG Geurts JJG Geurts JJG Geus JCN de Geus JCN de Geus JCN de Geus JCN de Groenewegen HJ Groenewegen HJ Groenewegen HJ Groffen AJA Groffen AJA Gunst MCM de Heutink P Heutink P Heutink P Nycteumdag Huisartsen, Vroeg of laat in de ziekte van Parkinson, Parkinson(isme) moet je zien DC-SIGN controls immune homeostatis in the brain; Bethesda, USA - Workshop on recognition of host and pathogen glycans by mammalian GBPs and mammalian GBPs in immune cell communication NVVI annual meeting 2010; Noordwijkerhout, Netherlands - Title: Homeostatic interaction of CNS myelin with DC-SIGN-expressing microglia prevents neuroinflammation Computational statistics for the identification of transcriptional gene regulatory interaction - workshop "Nonlinear Dynamics of Natural Systems", EURANDOM, Eindhoven Gene Expression Modeling Using Lasso - workshop "Statistique Mathématique et Applications" à Fréjus (France) International experts meeting; Goettingen, Germany - Title: Neuropathology of cognitive decline. Calgary, Canada - Title: in MS: where does it all start? Milan, Italy - Title: DIR imaging of cortical pathology in MS. ECTRIMS, Götenborg, Sweden - Title: High field imaging of cortical lesions in MS. MAGNIMS workshop; Warwick, UK - Title: Cognitive dysfunction and rehabilitation. School for Sports and Exercise Birmingham University, Birmingham, UK: Determinants of exercise behaviour: a behaviour genetics perspective Genetics consortium meeting NIH, Bethesda, USA: NTR Biobanks Twin Seminar Series Epidemiology, Erasmus MC, Rotterdam: Does regular exercise increase well-being?: Using longitudinal data in genetically informative subjects to test causal hypotheses Symposium t.g.v. afscheid prof. Helders, Utrecht: Bewegen zit in onze genen Paris, Symposium in honor of Jean- Michel Deniau. Title: Basal ganglia and friendship. Annual Meeting, Dutch Anatomical Society. Title: Neuroanatomy for Anatomists IBRO International Conferences, Pecs, Hungary - Title: Comparative anatomy of the ventral striatum FENS 2010, Doc2b is a Ca2+ sensor for spontaneous release EPS symposium (on plant endomembranes), Molecular mechanism of Ca2+-dependent membrane fusion: lessons from the mouse brain Nederlands Mathematisch Congres - Mathematics meets Neuroscience Gene finding for Parkinsons disease in isolated populations. University of Birmingham (UK) RIKEN Omics Institute, Yokohama, Japan. Neurodegenerative disease: the case of the missing heritability. Annual meeting of the Indian Society of Human Genetics, Lucknow India. Targeting Gene networks in Parkinsons disease 22/04/ /05/2010 White Matter Disease 16-17/12/2010 White Matter Disease 14/04/ /09/2010 Integrative Analysis & Modeling Integrative Analysis & Modeling 11-12/06/2010 White Matter Disease 19/06/2010 White Matter Disease September 2010 White Matter Disease 12/10/2010 White Matter Disease 11-12/11/2010 White Matter Disease 26/11/2010 Anxiety & Depression 04/05/2010 Anxiety & Depression 22/02/2010 Anxiety & Depression 12/11/2010 Anxiety & Depression 11/06/ /01/ /01/ /07/ /07/ /04/2010 Systems Biology of the Synapse Systems Biology of the Synapse Integrative Analysis & Modeling 08/02/ /02/ /03/

118 Heuvel OA van den Heuvel OA van den Hillebrand A Hillebrand A Hillebrand A Hoogendijk WJG Hoogendijk WJG Hoozemans JJM Horssen J van Jonker JA Jonker JA Jonker JA Jonker JA Jonker JA Knaap MS van der Knaap MS van der Knaap MS van der Knaap MS van der Knaap MS van der Knaap MS van der Knaap MS van der Knaap MS van der Valeriussymposium neuro- en ouderenpsychiatrie, Parkinson en dwangstoornis neuroanatomisch verbonden ICOCS symposium, the structure of the OCD brain Graph analysis in neuroscience Autumn School 2010, Eberhard Karls University, Tübingen MEG beamformer applications MEG at the VUmc. Past, present and future. Amsterdam Functional connectivity in Obesity, Diabetes and Alzheimer Biomag 2010, Dubrovnik KNAW conference Genomics and Gene Expression Jegersma lazing Leiden. Molecular markers for Major Depression XVIIth Intern. Congress of Neuropathology - ER stress in neurodegeneration ECTRIMS. Gothenborg, Sweden - Title:Reactive oxygen species in multiple sclerosis pathogenesis: from source to solution On the localisation of rare causal variants in a case-control association study, LUMC Statistical method for mapping disease genes - workshop "Nonlinear Dynamics of Natural Systems", EURANDOM, Eindhoven On the localisation of rare causal variants in a case-control association study - VUMC A frailty model for censored family survival data, applied to the age at onset of mental problems - LUMC A frailty model for censored family survival data, applied to the age at onset of mental problems - Delft American Academy of Neurology 62nd Annual Meeting, Novel leukoencephalopathies: VWM, MLC and LBSL - diagnosis and research American Academy of Neurology 62nd Annual Meeting, MRI approach to the diagnosis of leukoencephalopathies Joint Annual Meeting of the Intern. Society for Magnetic Resonance in Medicine and the European Society for Magnetic Resonance in Medicine and Biology, Genetic dysregulation and white matter MR phenotype Annual Symposium of the United Leukodystrophy Foundation, New Leukodystrophy update International Symposium on Multiple Sclerosis and Myelin Disorders, Clinical aspects, MRI pattern recognition and genetics of myelin disorders Neurowoche, Neuroradiologische Diagnostik neuer Entitäten Neurowoche, From new MRI patterns to disease genes Annual meeting of the Association of British Neurologists, Childhood and adult leukodystrophies 03/11/ / Anxiety & Depression Brain Imaging 24-25/11/2010 Brain Imaging 31/05/2010 Brain Imaging 28/03-01/04/2010 Brain Imaging 07/01/ 2010 Anxiety & Depression 2010 Anxiety & Depression 11/09/ /10/2010 White Matter Disease 31/03/ /04/ /05/ /06/ /11/2010 Kock CPJ de MPI Florida, USA 05/02/2010 Kock CPJ de HHMI, Janelia Farm, D.C., USA 26/04/2010 Integrative Analysis & Modeling Integrative Analysis & Modeling Integrative Analysis & Modeling Integrative Analysis & Modeling Integrative Analysis & Modeling 12/04/2010 White Matter Disease 12/04/2010 White Matter Disease 07/07/2010 White Matter Disease 08/07/2010 White Matter Disease 20/08/2010 White Matter Disease 23/09/2010 White Matter Disease 24/09/2010 White Matter Disease 30/09/2010 White Matter Disease Attention & Cognition Addictive Behavior Systems Biology of the Synapse Attention & Cognition Addictive Behavior Systems Biology of the Synapse 116

119 Kock CPJ de MPI Tuebingen, Germany 25/05/2010 Kock CPJ de MorphComp workshop, Amsterdam 08/07/2010 Kooyk Y van Kreukels BPC Kreukels BPC Kuijper EAM, Ket JCF, Lambalk CB. Lambalk CB Lambalk CB Lambalk CB Lambalk CB Lambalk CB Lambalk CB Lambalk CB, Kuijper EAM Lambalk CB, Vink J, Stroom E, Boomsma DI Leday G MA Jonker Mansvelder HD Mansvelder HD Mansvelder HD MS Immunology Meeting, Nottingham, UK - Title: Dendritic cells in the control of homeostatis and inflammation in MS Neuroendocrinologie Symposium Hormonen & Psyche, Effects of sex steroid hormones on behaviour and cognitive functioning. KI-RGD Annual meeting. Karolinska Institute Stockholm, Sex hormones and the brain: studies in the Dutch gender identity clinic. Perinatal endocrinology of twins. 13th International Congress on Twin Studies, Seoel, Zuid Korea. The Endocrinology of Dizygotic twinning. 13th Annual meeting of the Dutch Endocrine Society, Noordwijkerhout. The Biology of twinning in the human. Inaugural Lecture, Universiteit van Gent, Gent, België. The Omics for oocyte and Embryoselection. How to survive new technologies in the IVF Lab? 23rd Meeting of the Belgium Society of Reproductive Medicine, Leuven, België. Vruchtbaarheid na kanker - Jaarcongres Lymfklierkanker Vereniging Nederland, Ede Improving efficacy of GnRH antagonists. Sixth Worldcongress on Ovulation Induction. Napels, Italië. The multiple pregnancy, recent highlights of obstetrical research. 13th International Congress on Twin Studies, Seoel, Zuid Korea. Reproductief endocrinologische geboortespiegels bij tweelingen. Eerste wetenschappelijke discussiedag Gent/VUmc, Gent, België Nationwide comparison of perinatal outcome of induced versus natural twins in the Netherlands Ovarian ageing and twinning 13th International Congress on Twin Studies, Seoel, Zuid Korea. Cancer Bioinformatics Workshop, Cambridge Research Institute, Cambridge, UK - Multi-regime models for DNA copy number and gene expression association A frailty model for censored family survival data, applied to the age at onset of mental problems - STAR meeting, Eindhoven Attention & Cognition Addictive Behavior Systems Biology of the Synapse Attention & Cognition Addictive Behavior Systems Biology of the Synapse 31/10-01/11/2010 White Matter Disease 14 /10/2010 Affliated Research 17/11/ 2010 Affliated Research 04-07/06/2010 Affliated Research 29-30/01/2010 Affliated Research 23/02/2010 Affliated Research 26/03/2010 Affliated Research 27/03/2010 Affliated Research 30/09-02/20/2010, Affliated Research 4-7/06/2010 Affliated Research 25/11/2010 Affliated Research 4-7/06/2010 Affliated Research 02/09/ /12/2010 InMed, Marseille 15/02/2010 Neuroscience Campus Amsterdam 01/04/2010 FENS satellite, Amsterdam 01/07/2010 Integrative Analysis & Modeling Integrative Analysis & Modeling Attention & Cognition Addictive Behavior Systems Biology of the Synapse Attention & Cognition Addictive Behavior Systems Biology of the Synapse Attention & Cognition Addictive Behavior Systems Biology of the Synapse 117

120 Mansvelder HD Mansvelder HD Mansvelder HD Middeldorp CM Middeldorp CM ECNP meeting, Amsterdam 30/-8/2010 Hebrew University Jerusalem, Israel 23/12/2010 Technion research institute Haifa, Israel 28/12/2010 XVIIIth World Congres for Psychiatry Genetics: the overlap of genetic risk factors for the five personality traits and depression 38th Spring congress of the Dutch Psychiatric Association: Genetic risk profiles for depression and anxiety October 2010 April 2010 Ooyen A van Mathematical Neuroscience, UK 20/04/2010 Ooyen A van Groningen University 13/04/2010 Ooyen A van VUmc, Amsterdam 08/03/2010 Ooyen A van FENS workshop, Amsterdam 08/07/2010 Penninx BWJH Penninx BWJH Penninx BWJH Penninx BWJH Penninx BWJH Posthuma D Posthuma D Posthuma D Posthuma D Posthuma D Posthuma D Posthuma D Posthuma D Reijerkerk A Erasmus University Rotterdam. Psychiatric epidemiology. Keynote lecture Valeriussymposium Psyche and Soma. Depression and cardiovascular disease. American Psychiatric Association, New Orleans. Depression, metabolic syndrome, obesity. National Institute of Mental Health, Maryland. the Netherlands Study of Depression and Anxiety. Keynote lecture Annual Meeting Neurioscience Campus Amsterdam. Depression, endophenotypes and genes: insights from NESDA. Conference on Genetics and Neurobiology of Mental Retardation. Keynote lecture: Genetic foundations of human intelligence. 2010, Erlangen Germany Symposium on Neuroimaging, genetics and endophenotypes, Rotterdam. Functional genetic pathways and their role in psychopathology, SARA computing centre Amsterdam, Annual LISA user s day. Cluster computing in human genetics. Netherlands Institite for Neurosciences Lecture Series.Gene Finding for complex traits: synaptic mechanisms in cognition. UMCG seminar Series, Groningen Functional gene networks for complex traits: synaptic mechanisms in cognition. The 2010 International Workshop on Statistical Genetics and Methodology of Twin and Family Studies, March 1-5, Boulder, CA, USA Multivariate Genetic Modelling. Systems Biology Meeting, Amsterdam. Synaptic Mechanisms in Complex Traits. Annual Meeting of Determinants of Executive Function & Dysfunction - An NIMH Funded Interdisciplinary Behavioral Science Center, Genes, Environment and Intelligence. Boulder, Colorado, US Second Cold Spring Harbor conference on Blood Brain Barrier, Molecular control of the blood-brain barrier. Cold Spring Harbor, NY, USA. Attention & Cognition Addictive Behavior Systems Biology of the Synapse Attention & Cognition Addictive Behavior Systems Biology of the Synapse Attention & Cognition Addictive Behavior Systems Biology of the Synapse Anxiety & Depression Anxiety & Depression Integrative Analysis & Modeling Integrative Analysis & Modeling Integrative Analysis & Modeling Integrative Analysis & Modeling 17/09/2010 Anxiety & Depression 05/06/2010 Anxiety & Depression 21/03/2010 Anxiety & Depression 03/03/2010 Anxiety & Depression 01/04/2010 Anxiety & Depression 01/10/ /09/ /05/ /04/ /04/ /03/ Integrative Analysis & Modeling Integrative Analysis & Modeling Integrative Analysis & Modeling Integrative Analysis & Modeling Integrative Analysis & Modeling Integrative Analysis & Modeling Integrative Analysis & Modeling Integrative Analysis & Modeling 08-11/1/2010 White Matter Disease 118

121 Reijerkerk A Reijerkerk A Ros B Rozemuller JM Rozemuller JM Rozemuller JM Rozemuller JM Salomons GS Salomons Gs Scheltens Ph Scheltens Ph MS-dagen, micrornas control brain endothelial cell barrier function and immune quiescence Institute of Neurology (Edinger-Institute), Medical School Goethe University Frankfurt, Germany, The brain endothelial cell barrier, the influence of environmental factors and micrornas. STAR conference, Modeling brain network dynamics Britisch Neuropathol Soc, 111th meeting, London; Characteristics of capillary Cerebral Amyloid Angiopathy (capcaa)with abeta or prion deposits. Lunteren Annual Meeting Neurology PhD training in Pathology. Pathology of the Dementia s Sec. Int. CAA meeting, Los Angelos. Title: Inflammatory changes, neurofibrillary degeneration and loss of tight junctions in and around Congophilic vessels in AD and a new form of prion CAA Annual Congres Neuropsychiatrie A dam Lessen uit neuropathologisch onderzoek bij psychiatrische patienten VII International Symposium of the Portuguese Society of Metabolic Disorders (SPDM) Algarve, Portugal: Creatine deficiency syndromes European Society of Pediatric Neurology, Leuven, Belgium: Creatine deficiency syndromes Amsterdam: KNAW - CSF analysis in dementia Berlijn: KKND/D ZNE - Use of biomarkers in dementia 14-15/12/2010 White Matter Disease 18/08/2010 White Matter Disease 03/12/2010 Integrative Analysis & Modeling 07/01/ /04/ /05/ /11/ /11/2010 White Matter Disease 1-2/10/2010 White Matter Disease 15/03/ / Scheltens Ph Florence: Lundbeck - Treatment of AD 18/ Scheltens Ph Geneve: Springfield; Conference - Vascular factors in AD: implications for 24/03/2010 treatment Scheltens Ph Boston: MIT - Synaps dysfunction in AD: treatment options 16/05/2010 Scheltens Ph Hong Kong: ICNP - Progress in trial design 06/06/2010 Scheltens Ph Hawaii: ICAD - Use of biomarkers in dementia 13/07/2010 Scheltens Ph Bucharest: Rumanian Medical Academy - Rethinking the design of clinical trials in 03/09/2010 AD Scheltens Ph Geneve: EFNS Luigi Amaducci teaching course on 25/09/2010 dementia Scheltens Ph Brno: Czech Neurological Society - NeuroImaging in dementia 07/10/2010 Scheltens Ph Trondheim: NTNU Faculty Medecine - The chalenge for the future in AD 12/10/2010 Scheltens Ph Toulouse: CTAD - Design of future AD trials 03/11/2010 Scheper GC 175th ENMC workshop on Mitochondrial Protein synthesis in health and disease 27/06/2010 White Matter Disease Scheper GC ZonMW Priority Medicine 09/12/2010 White Matter Disease Sluis S van der Sluis S van der Sluis S van der Sluis S van der Biological Psychology, VU University - False positives in the GxE model proposed by Purcell Psychological Methods Department, University, of Amsterdam - False positives in the GxE model proposed by Purcell Statisticis for the Life Sciences Department, VU University - Gene finding for complex traits Psychological Methods Department, University of Amsterdam - Gene finding for complex traits 13/10/ /12/ /05/ /04/2010 Integrative Analysis & Modeling Integrative Analysis & Modeling Integrative Analysis & Modeling Integrative Analysis & Modeling 119

122 Smit JH Smit JH Someren EJW van Someren EJW van Someren EJW van Someren EJW van Someren EJW van Someren EJW van Someren EJW van Someren EJW van Someren EJW van Someren EJW van Someren EJW van Someren EJW van Someren EJW van Conference on Regiters in Sicaal Wetenschappelijk Onderzoek, mogelijkheden en valkuilen. Continuiteit van zorg. Indicatoren van langetermijn zorg in de GGZ. Reactie. Lingitudinal Aging Study Amsterdam. Mixed mode designs: gevolgen voor respons, datakwaliteit en analyses. Circadian rhythms, sleep and cognition in aging, Invited lecture at the FUTURAGE-WHYWEAGE Conference, Brussels Sleep and Aging, Invited lecture Course Higher Education for Older People (HOVO), Leiden A brightly lit environment improves quality of life in demented elderly residents of care facilities, Invited lecture Annual Congress of the Elderly Care and Medicine Specialists Society (Verenso), Apeldoorn Lying awake of insomnia, Inaugural lecture VU University, Amsterdam Sleep and Brain Function in Aging and Alzheimer s disease, Invited lecture at the 2010 Royal Society for Medine Meeting, London Bright Light for Elderly People: Randomized Clinical Trials, Invited lecture Symposium Light and Care of the Light and Health Research Foundation (SOLG), Eindhoven Sleep, cognition and brain function in old age, dementia and insomnia, Invited lecture University of Surrey Dept of Biochemical Sciences, Guildford Jet Lag, Invited lecture October Month of Knowledge Okura, Amsterdam Structural and functional consequences of sleep-wake rhythm fragmentation in the elderly and Alzheimer s disease, Symposium Sleep and cognition in aging and Alzheimer's disease at the 20th Congress of the European Sleep Research Society, Lisbon Large-scale internet assessment to find insomnia phenotypes: the Netherlands Sleep Registry going EU?, Symposium Strategic steps towards understanding and treating insomnia by EUcooperation - a report from the European Insomnia Network at the 20th Congress of the European Sleep Research Society, Lisbon Skin temperature level predicts vigilance lapses and improves actigraphic sleep estimate accuracy, Symposium Sleep and temperature regulation from the laboratory to the clinic at the 20th Congress of the European Sleep Research Society, Lisbon Brain imaging consequences of experimental sleep deprivation versus chronic insomnia, Symposium The impact of restricted or disrupted sleep on molecular and neurophysiological mechanisms underlying cognitive function and memory at the 20th Congress of the European Sleep Research Society, Lisbon Large-scale internet assessment to find insomnia phenotypes: the Netherlands Sleep Registry, Annual meeting of the Netherlands Society for Sleep-Wake Research, Nieuwegein June 2010 December 2010 December 2010 December 2010 November 2010 November 2010 November 2010 November 2010 November 2010 October 2010 September 2010 September 2010 September 2010 September 2010 September 2010 Anxiety & Depression Anxiety & Depression Attention & Cognition Attention & Cognition Attention & Cognition Attention & Cognition Brain Imaging Attention & Cognition Brain Imaging Attention & Cognition Brain Imaging Anxiety & Depression Attention & Cognition Brain Imaging Anxiety & Depression 120

123 Someren EJW van Someren EJW van Someren EJW van Someren EJW van Someren EJW van Someren EJW van Someren EJW van Someren EJW van Someren EJW van Someren EJW van Someren EJW van Someren EJW van Someren EJW van Someren EJW van Someren EJW van Stam CJ Stam CJ Stam CJ Sleep, cognition and brain function in old age, dementia and insomnia, Invited lecture Trimbos Instituut, Utrecht Cognitive vulnerability to disturbed sleep in elderly people, Lecture at the Sleep and Memory Symposium Experimental Psychology Society Meeting 2010, Manchester Slow Brain Oscillations of Sleep, Resting State and Vigilance, Opening lecture at the 26th International Summerschool of Brain Research, Amsterdam Sleep, cognition and brain function in old age, dementia and insomnia, Invited lecture at the Neurovation Symposium on Innovative Applications of Brain Science, Eindhoven Brain Imaging reveals affected brain circuits in chronic insomnia, the most prevalent yet forgotten CNS disease at high age, Invited lecture at the CTMM-TI Pharma joint workshop Brain diseases in the picture, Utrecht Tales of 1000 sleepless nights [in Dutch], Invited lecture at the Alumni Day of the University of Amsterdam, Amsterdam Temperature regulation improves sleep, Invited lecture at the International Symposium New Perspectives in Sleep Medicine at the 300th anniversary of the Charité, Berlin Tales of 1000 sleepless nights [in Dutch], Invited lecture at the Physics Meeting of the Royal Netherlands Academy of Arts and Sciences, Amsterdam Sleep, cognition and brain function in old age, dementia and insomnia, Second international symposium of the Leiden Institute for Brain and Cognition (LIBC): Sleep(less) in Leiden, Leiden Circadian rhythms and functioning in neurodegenerative disease, Invited lecture Nederlands Oogheelkundig Gezelschap, Amersfoort Sleep, cognition and brain function in old age, dementia and insomnia, Invited lecture Department of Integrative Physiology University of Colorado, Boulder How to measure circadian rhythms in clinical practice and everyday life, Invited lecture Department of Integrative Physiology University of Colorado, Boulder Sleep, cognition and brain function in old age, dementia and insomnia, Invited lecture University Children's Hospital, Zurich Sleep and functional capacity in aging, First meeting of the NINA EU group, Brussels Ambulatory thermoregulatory system identification in relation to vigilance disturbances, Annual meeting of ThermoNed, Eindhoven Internet in our head? VUmc minisymposium Caught in your own web, VUmc, Amsterdam Is MEG / EEG network analysis useful in clinical epilepsy research? Epilepsy & Sleep Update & Kempenhaeghe.nl. Heeze EEG op de intensive care. Landelijke nascholingsdagen laboranten klinische neurofysiologie, Ede September 2010 Brain Imaging July 2010 Attention & Cognition June 2010 Brain Imaging June 2010 June 2010 Brain Imaging June 2010 Brain Imaging May 2010 Attention & Cognition March 2010 Brain Imaging March 2010 Brain Imaging March 2010 February 2010 Brain Imaging February 2010 February 2010 Brain Imaging January 2010 Attention & Cognition January 2010 Attention & Cognition 18/03/2010 Brain Imaging 25/03/2010 Brain Imaging 09/04/2010 Brain Imaging 121

124 Stam CJ Stam CJ Stam CJ Stam CJ Stam CJ Stam CJ Stam CJ Stam CJ Stam CJ Stam CJ Stam CJ Teunissen CE Teunissen CE Veltman DJ Veltman DJ Verhage M Vermeulen RJ How are brain networks organized? European Low Grade Glioma Network 6th Meeting. Utrecht Pifalls in EEG diagnostiek. KNF dagen 2010, Nunspeet The future of MEG at the VUmc. MEG at the VUmc. Past, present and future. Amsterdam Disruption of synchronization processes in neuropsychiatric diseases: a complex brain networks perspective. SYNCLINE 2010: Synchronization in Complex Networks. Bad Honnef Brain networks in epilepsy: lessons from graph theory. Corticothalamic circuit involvement in seizure generation. Satellite symposium FENS FORUM Amsterdam Characterization of resting-state functional connectivity in the brain: a complex networks perspective. Keynote Lecture. 15th World Congress of Psychophysiology. Budapest Graph theoretical analysis of multivariate neurophysiological signals. Nederlandse Ver. voor Technische Geneeskunde, TU Twente, Enschede Special lecture: Cortico-cortical functional coupling: what can we learn from graph theory? ICCN th International Congress of Clinical Neurophysiology Analysis methods: new approaches to the characterization of functional brain networks Symposium: High resolution EEG analysis. ICCN th International Congress of Clinical Neurophysiology The breakdown of functional connectivity in neuropsychiatric disease Symposium: Functional and effective connectivity. ICCN th International Congress of Clinical Neurophysiology The battered brain: what complex networks science can teach us about brain disease. Robustness of complex networks, Delft; workshop/accomendation World Federation of Neurology Biomarker Meeting, Ulm, Germany - Title: Biomarkers multiple sclerosis Trends Biomarkers in the early diagnosis of neurodegenerative disorders, Perugia, Italy - Title: Advances in proteomic research in multiple sclerosis Afscheidssymposium prof. M. Hengelveld. Neuro-imaging in de psychiatrie: pathofysiologie en praktijk. American Psychiatric Association (APA) 2010 annual meeting, New Orleand- Effect of cognitive behavioural stabilizing group treatment on brain activity in childhood-abuse related complex PTSD patients Gordon Conference (Cell Biology of the Neuron), DOC2B is a Ca2+-sensor for spontaneous release in CNS synapses The Clinical Value of intensive Monitoring in Term Asphysiated Newborn. Predictive value of conventional and diffusion weighted MRI for clinical outcome after perinatal asfyxia. Rotterdam, The Netherlands. 10/04/2010 Brain Imaging 23/04/2010 Brain Imaging 31/05/2010 Brain Imaging 26-29/05/2010 Brain Imaging 02/07/2010 Brain Imaging 1-4/09/2010 Brain Imaging 01/10/2010 Brain Imaging 28/10-01/11/ 2010 Brain Imaging 28/10-01/11/ 2010 Brain Imaging 28/10-01/11/ 2010 Brain Imaging 14-16/11/2010 Brain Imaging 15-16/07/2010 White Matter Disease 3-4/06/2010 White Matter Disease 05/02/2010 Brain Imaging 24/05/2010 Brain Imaging 27/06-02/07/2010 Systems Biology of the Synapse 22/04/2010 White Matter Disease 122

125 Vermeulen RJ Vermeulen RJ Visser PJ Visser PJ Visser PJ Visser PJ Visser PJ Visser PJ Visser PJ Vries HE de Vries HE de Vries HE de Vries HE de Vries HE de Vries HE de Vries TJ de Vries TJ de Vries TJ de Pediatric Neurology Rounds. Prediction and outcome after perinatal hypoxic ischemia at two years: the role MR and clinical testing. Mc Master University, Hamilton, Canada Late effecten van Neonatale cerebellaire schade. Nederlandse vereniging voor Kindergeneeskunde, congres 2011, Veldhoven 25th International Conference of Alzheimer s Disease International: MCI and the early diagnosis of AD Alzheimer Antibody Conference: The European Joint programming initiative on, in particular Alzheimer s disease Seminar department of Neurology, UMC St Radboud: Alzheimer biomarkers in subjects with MCI. Implications for diagnosis and prognosis Geriatric Medicine Symposia-Brain Aging Hot topics 2010: Mild cognitive impairment and the diagnosis of Alzheimer s disease Nationaal Dementia Symposium: Biomarkers for Alzheimer s disease in subjects with mild cognitive impairment. Implications for diagnosis and prognosis Expert working group meeting on European dementia research. Breakfast debate at the European Parliament: Alzheimer research funding on the European level. The Joint programming initiative on Lunch debate at the European Parliament organised by Alzheimer Europe: Alzheimer research funding on the European level. The Joint programming initiative on 10th symp. Intern. Society for Neuro- Immunology, Sitges, Spain - Title: ABC transporters and neuro-inflammation 10th Signal Transduction in the Blood- Brain Barrier, Zurich Switzerland - Title: ABC transporters at the blood-brain barrier Barriers of the CNS, Gordon Research conference, Tilton, USA - Title: The bloodbrain barrier in neurological disorders COST Neurinfnet Meeting Inflammation in Brain Disease, Odense Denmark - P- glycoprotein as novel immunomodulator in MS COST Exploratory workshop Blood brain barrier pharmacology and physiology Brussels, Belgium - Title: The blood-brain barrier in neurological disorders MRI in MS, annual ARSERP meeting Paris France - Title: Imaging cellular infiltration in models of MS Insights into the Neurobiology of Addiction; Aquitaine 2010 Conferences, Bordeaux, France - Title: Genetic, molecular, cellular and behavioural approaches to identify neurobiological factors underlying enhanced vulnerability to drug seeking Annual meeting, Neuroscience Campus Amsterdam - Title: Prefrontal cortex plasticity in drug seeking and relapse 7th FENS FORUM, Amsterdam - Title: Neurobiological factors determining high vulnerability to drug seeking and relapse. 01/10/2010 White Matter Disease 03/11/2010 White Matter Disease 10/03/ /04/ /07/ /10/ /11/ /11/ /12/ /10/2010 White Matter Disease 01-04/09/2010 White Matter Disease 11-12/02/2010 White Matter Disease 10-11/05/2010 White Matter Disease 10-11/02/2010 White Matter Disease 04-05/02/2010 White Matter Disease 12-15/10/2010 Addictive Behavior April Addictive Behavior 03-07/07/2010 Addictive Behavior 123

126 Vries TJ de Wamelink MMC Werf YD van der Werf YD van der Werf YD van der Wilhelmus M Wit H de Wit H de Wit H de Wit H de Witte S Witte S Wolf NI Wolf NI CNCR minisymposium Nico-teen: about adolescence and nicotine - Title: Impulsivity: a risk factor for the initiation and persistence of nicotine seeking Czech- Slovakia Metabolic Group meeting, Bratislava, Slovakia, Pentose phosphate pathway. Biochemistry, metabolism and inherited defects Université Libre de Bruxelles, seminar as invited speaker. Title Neuroimaging studies of sleep and memory 12th Annual Intern. Symposium "Epilepsy and Sleep Kempenhaeghe.nl" Title: Sleep benefits memory for things past and things to come 26th Summerschool of Brain Research Slow Brain Oscillations of Sleep, Resting State and Vigilance : Sleep benefits subsequent hippocampal functioning Microglia symposium, Amsterdam, The Netherlands - Title: Microgliosis in the anterior olfactory nucleus of Parkinson and Alzheimer patients MECHANISMS of EXOCYTOSIS, Jerusalem, Israel - Titel: Molecular Mechanisms of Secretory Vesicle Docking Annual meeting Neuroscience Campus Amsterdam - Titel: Molecular Mechanisms of Docking Gordon conference: Cell biology of the neuron, Waterville valley resort, NH, USA - Titel: Synaptotagmin-1 docks secretory vesicles to syntaxin-1/snap-25 acceptor complexes Synapse symposium: FENS 2010 satellite, Rode Hoed, Amsterdam, NL - Titel: Synaptotagmin-1 docks secretory vesicles to syntaxin-1/snap-25 acceptor complexes Shining light on the brain: Highresolution imaging of brain tissue using nonlinear microscopy, Fysica 2010, Utrecht, The Netherlands. Label-free live brain imaging with ultrafast nonlinear microscopy, 17th International Conference on Ultrafast Phenomena, Snowmass, Colorado, USA 38ème Réunion de la Société Européenne de Neurologie Pédiatrique, Geneva: Il y a hypomyélinisation et hypomyélinisation - les causes en sont diverses, et l IRM n est pas tout. 9th European Congres on Epileptology, Rhodes: Epilepsy as a presentation of neurometabolic disorders. 08/10/2010 Addictive Behavior 05-07/05/2010 White Matter Disease 29/11/2010 Attention & Cognition 26/03/2010 Attention & Cognition 01/07/2010 Attention & Cognition 17/03/ /03/ /04/ /06-02/07/ /07/ /04/ /07/2010 Systems Biology of the Synapse Systems Biology of the Synapse Systems Biology of the Synapse Systems Biology of the Synapse Photonics & Life Cell Imaging Photonics & Life Cell Imaging /03/2010 White Matter Disease 27/06-01/07/2010 White Matter Disease Organization of congresses Investigator Naam Congres, locatie datum Program Amor S Organizer and chairperson. British Society for Immunology, Liverpool Barkhof F, Dijkstra CD, Polman C, Uitdehaag BMJ, Geurts JJGJ, Vrenken H, Vries HE de, Teunissen CE Member local organizing committee 27th ECTRIMS and 16th ACTRIMS/, RAI Amsterdam 2010 White Matter Disease 19-22/10/2010 White Matter Disease Bartels M BGA: Internalizing Behaviour 05/06/2010 Anxiety & Depression 124

127 Berg, W.J.D. van de, Dam AMW van Boomsma DI Boomsma, DI, Penninx BWJH Boomsma. DI, Middeldorp CM Cornelisse LN Dam AMW van Flier WM van der Heutink P HillebrandA, Stam CJ Hoozemans, JJM Kooyk Y van Lambalk CB Lambalk CB Lambalk CB Mansvelder HD FENS satellite meeting Alpha-synuclein pathology in Parkinson patients and models Behavior Genetics Association yearly conference, South Korea Genomics of gene expression, KNAW, Amsterdam Voorjaarscongres NL Vereniging Psychiatrie: Symposium Genetica en Diagnostiek. Workshop NISB, Systems Biology of the Synapse VUA, Amsterdam FENS satellite symp. Alpha-synuclein pathology in Parkinson patients and models - VUmc, Amsterdam ICAD 2010, Hawaii: Scientific Committee Member of the Scientific Program Committee (SPC) of the European Society of Human Genetics (ESHG) for the annual meeting of the society. MEG at the VUmc. Past, present and future XVIIth Intern. Congress of Neuropathology - ER stress in neurodegeneration Workshop host and pathogen glycans by mammalian Glycan binding proteins, CFG, NIH, Bethesda, USA 13nd International Congress for Twin Studies, Seoel Annual Meeting Dutch Endocrine Society, Noordwijkerhout 14th International Congress for Twin Studies, Florence FENS satellite, GABA signalling in the brain 02/07/ /06/2010 Anxiety & Depression Attention & Cognition Addictive Behavior 07-08/01/2010 Anxiety & Depression 15/04/2010 Anxiety & Depression 19/02/2010 Systems Biology of the Synapse 02/07/2010 Juli /06/ /05/2010 Brain Imaging 11/09/ /05/2010 White Matter Disease 04-7/06/2010 Affliated Research 29/01/2010 Affliated Research April /06-02/07/2010 Mansvelder HD FENS satellite, Slow brain oscillations 29/06-02/07/2010 Ooyen A van Penninx BWJH Reijerkerk A Reijerkerk A Reijerkerk A Rozemuller JM Rozemuller JM Rozemuller JM Rozemuller JM Simon Sanchez J FENS workshop, Single neuron morphologies and computation KNAW symposium Genomics of Depression, Amsterdam. Lecture title: Genetic research in the NESDA study. Member organizing committee 9th Cerebrovascular Biology meeting (CVB, 2011) Leiden, The Netherlands Annual meeting of the Dutch Endothelial cell Biology Society Sanquin, Amsterdam Member organizing committee First Cardio Vascular Conference, Noordwijkerhout, The Netherlands Amsterdam Minisymposium Role of micro-glia in neurodegeneration - VUmc Co-chair satellite meeting International Parkinson congress VUMC Chairman Symposium VUmc Chairman International Symposium on Microglia VUmc Parkinson Disease GWAS, VUMC, Amsterdam 08-09/07/2010 Affliated Research Attention & Cognition Addictive Behavior Systems Biology of the Synapse Attention & Cognition Addictive Behavior Systems Biology of the Synapse Integrative Analysis & Modeling 07-08/01/2010 Anxiety & Depression 21-25/06/2011 White Matter Disease 01/10/2010 White Matter Disease 17-18/03/2011 White Matter Disease 17/03/ /07/ /06/2010 June 2010 Smit AB Synsys Kick Off, RAI Amsterdam 04/07/2010 Someren EJW van Strategic steps towards understanding and treating insomnia by EUcooperation - a report from the European Insomnia Network. Co-chair 21-22/03/2010 September 2010 Systems Biology of the Synapse Anxiety & Depression 125

128 Someren EJW van Someren EJW van Someren EJW van Verhage M (a.o.) Verhage M, Toonen RFG Verheijen M Vies SM van der Visser PJ Vries HE de Vries HE de Vries HE de Werf YD van der Wit M de Wouterlood FG of an European Network Session at the 20th Congress of the European Sleep Research Society Learning and memory functions. Cochair of the Symposium Learning and memory functions at the 20th Congress of the European Sleep Research Society Insomnia treatment. Member of the Round Table Insomnia Treatment at the 20th Congress of the European Sleep Research Society Slow Brain Oscillations of Sleep, Resting State and Vigilance. 26th International Summerschool of Brain Research and official pre-fens satellite, organized by the Netherlands Institute for Neuroscience of the Royal Netherlands Academy of Arts and Sciences, the VU University Amsterdam, the University of Amsterdam and the Leiden University Medical Center. Septemeber 2010 September 2010 June-July 2010 FENS Forum 2010, Amsterdam 03-07/07/2010 The Synapse Symposium, Amsterdam 01-03/07/2010 Fens Satellite: 'Tripartite Synapses: from hypothesis to reality? Vrije Universiteit' Sym. on the occasion of the appointment of dr. Annemieke J.M. Rozemuller to Professor of Neuropathology Spotlight on Alzheimer s disease International (ADI) 2010, Thessaloniki: scientific committee 10th symposium Intern. Society for Neuro-Immunology (symposium chair) COST Neurinfnet Meeting Odense Denmark Chair organizing committee 9th Cerebrovascular Biology meeting (CVB, 2011) Leiden, The Netherlands 26th Summerschool of Brain Research Slow Brain Oscillations of Sleep, Resting State and Vigilance (coorganizer) BrainTrain kick-off meeting, Amsterdam, NL 7th FENS Amsterdam: workshop neuroanatomical tracing and Systems Neuroscience: the State of the Art Attention & Cognition Anxiety & Depression Brain Imaging Anxiety & Depression White Matter Disease Attention & Cognition Systems Biology of the Synapse Systems Biology of the Synapse 02/07/2010 White Matter Disease 18/06/2010 March /10/2010 White Matter Disease 10-11/05/2010 White Matter Disease White Matter Disease 29/06-02/07/2010 Attention & Cognition 29-31/10/2010 Systems Biology of the Synapse 03/07/2010 Editorships Investigator Journal Program Boomsma DI Twin Research and Human Genetics Brain Imaging Anxiety & Depression Attention & Cognition Geus JCN de Psychosomatic Medicine Brain Imaging Anxiety & Depression Geus JCN de Biological Psychology Brain Imaging Anxiety & Depression Attention & Cognition Heutink H Annals of Human genetics Lambalk CB Twin Research and Human Genetics Affliated Research Lammertsma, A.A. Deputy Chief-Editor Journal of Cerebral Blood Flow and Metabolism Brain Imaging Anxiety & Depression 126

129 Lammertsma, A.A. Lammertsma, A.A. Mansvelder HD Posthuma D International Associate Editor of Molecular Imaging and Biology Medical Physics & Radiation Protection Section Editor Nuklearmedizin Progress in Neurobiology, volume Slow Brain Oscillations of Sleep, Resting State and Vigilance Behavior Genetics Brain Imaging Anxiety & Depression Brain Imaging Anxiety & Depression Attention & Cognition Addictive Behavior Systems Biology of the Synapse Integrative Analysis & Modeling Scheltens Ph Alzheimer s Disease Assoc Dis Smit JH Associate Editor Frontiers Psychiatry Anxiety & Depression Someren EJW van Doing with less sleep remains a dream. PNAS 107: Brain Imaging Stam CJ Clinical Neurophysiology Veltman DJ Frontiers in Psychopathology (Review editor) Brain Imaging Visser PJ Associated Editor BMC Geriatrics Visser PJ Associated Journal of Alzheimer s disease Membership of editorial boards/advisory boards of a journal Investigator Journal / Book series Program Amor S CNS and neurological disorders drug targets White Matter Disease Barkhof F European Radiology White Matter Disease Barkhof F Multiple Sclerosis White Matter Disease Barkhof F Neuroradiology White Matter Disease Barkhof F Brain White Matter Disease Barkhof F Journal of Neurology, Neurosurgery and Psychiatry White Matter Disease Bochdanovits Z Member of Academic Editorial Board of PLoS ONE Castelijns JA Am. Journal of Neuroradiology White Matter Disease Castelijns JA European Radiology White Matter Disease Cohen-Kettenis P Archives of Sexual Behavior Affliated Research Cohen-Kettenis P Journal of Psychology and Human Sexuality Affliated Research Cohen-Kettenis P International Journal of Transgenderism Affliated Research Cohen-Kettenis P International Journal of Sexual Health Affliated Research Cohen-Kettenis P Tijdschrift voor Seksuologie Affliated Research Dam AMW van ISRN Neurology White Matter Disease Dam AMW van Neuropharmacology White Matter Disease Drukarch B Drukarch B Drukarch B American Journal of Neuroprotection and Neuroregeneration ISRN Neurology International Journal of Neuroprotection and Neuroregeneration White Matter Disease White Matter Disease Elsen P van den Immunogenetics White Matter Disease Elsen P van den The Open Immunology Journal White Matter Disease Geurts JJG. International MS Journal White Matter Disease Geus JCN de Psychophysiology Anxiety & Depression Attention & Cognition Addictive Behavior Geus JCN de Psychosomatic Medicine Brain Imaging Anxiety & Depression Geus JCN de MENPA Anxiety & Depression Attention & Cognition Addictive Behavior Groenewegen HJ Neuroscience Groenewegen HJ Brain Research Bulletin 127

130 Groenewegen HJ Basal Ganglia Gunst MCM de Journal: Statistics Surveys Integrative Analysis & Modeling Heutink P Neurogenetics Heutink P Member of Academic Editorial Board of PLoS ONE Hoogendijk WJG Acta Neuropsychiatrica Anxiety & Depression Jakobs C Journal of Inherited Metabolic Disease White Matter Disease Knaap MS van der Neuropediatrics White Matter Disease Kreukels BPC Neuropraxis Affliated Research Lambalk CB Lancet (editorial consultant) Affliated Research Lambalk CB Twin Research and Human Genetics Affliated Research Lambalk CB Reproductive Biomedicine Online (Section editor) Affliated Research Lammertsma, A.A. Lammertsma, A.A. Lammertsma, A.A. Lammertsma, A.A. Linkenkaer-Hansen K Mansvelder HD Mansvelder HD Ooyen A van Ooyen A van Ooyen A van Member Advisory Board Tijdschrift voor Nucleaire Geneeskunde Member Editorial Board BMC Medical Physics Member Editorial Board Current Medical Imaging Reviews Member Editorial Board European Journal of Nuclear Medicine and Molecular Imaging BMC Neuroscience PLoS One Frontiers in cellular neuroscience Frontiers in Neuroinformatics Current Opinion in Cognitive Neurodynamics Frontiers in Neuroinformatics Brain Imaging Anxiety & Depression Brain Imaging Anxiety & Depression Brain Imaging Anxiety & Depression Brain Imaging Anxiety & Depression Integrative Analysis & Modeling Attention & Cognition Photonics & Life Cell Imaging Drugs Screening & Therapy Design White Matter Disease Attention & Cognition Addictive Behavior Systems Biology of the Synapse Photonics & Life Cell Imaging Drugs Screening & Therapy Design White Matter Disease Attention & Cognition Addictive Behavior Systems Biology of the Synapse Integrative Analysis & Modeling Integrative Analysis & Modeling Integrative Analysis & Modeling Ooyen A van Current Opinion in Cognitive Neurodynamics Attention & Cognition Penninx BWJH Member of editorial board European Journal of Aging Penninx BWJH Member of editorial board International Journal of Behavioral Medicine Penninx BWJH Member of editorial board Journal of Gerontology: Medical Sciences Polman CH Lancet White Matter Disease Polman CH Multiple Sclerosis White Matter Disease Polman CH The International MS Journal White Matter Disease Posthuma D Twin Research and Human Genetics Integrative Analysis & Modeling Scheltens Ph Dementia Ger Cogn Dis Schoffelmeer ANM Synapse Addictive Behavior Someren EJW van Sleep Anxiety & Depression 128

131 Someren EJW van Journal of Sleep Research Attention & Cognition Someren EJW van Chronobiology International Affliated Research Someren EJW van Sleep and Biological Rhythms Attention & Cognition Stam CJ Journal of Neurology, Neurosurgery and Psychiatry Stam CJ Nonlinear Biomedical Physics Brain Imaging Stam CJ Human Brain Mapping Brain Imaging Stam CJ Tijdschrift voor Neurologie en Psychiatrie Uitdehaag BMJ Cochrane MS Group White Matter Disease Uylings HBM editorial board Brain Structure and Function (from 2007) Uylings HBM Editorial board Dutch journal NeuroPraxis ( from 2007) Verhage M Biology of the Cell Systems Biology of the Synapse Verweij CL Genes and Immunity White Matter Disease Verweij CL The Open Rheumatology Journal (editor-in-chief) White Matter Disease Visser PJ Mind and Brain - The Journal of Psychiatry Vries HE de Journal of Neuropathology and Experimental Neurology White Matter Disease Vries HE de Multiple Sclerosis International White Matter Disease Memberships (of academies) Investigator Organisation Program Amor S British Society Immunology, Neuroimmunology affinity group (chair) White Matter Disease Barkhof F Section of Neuroradiology of Dutch Society of Radiology (chairman) White Matter Disease Barkhof F National MS Society s Advisory Committee on Clinical Trials of New Drugs in MS (member) White Matter Disease Barkhof F Organization ERASMUS CNS-1 (coordinator) White Matter Disease Barkhof F Education committee Dutch Soc. of Radiology (chairman) White Matter Disease Barkhof F International Society for Magnetic Resonance in Medicine & White Matter Disease Study Group (member) White Matter Disease Barkhof F RSNA (member) White Matter Disease Barkhof F ASNR (member) White Matter Disease Barkhof F ESNR and ECR (member) White Matter Disease Barkhof F MAGNIMS study group (chairman) White Matter Disease Berendse HW International Basal Ganglia Society (board member) Berendse HW WFN Research Group on Parkinson s Disease and Related Disorders (member) Berendse HW Movement Disorder Society (member) Berendse HW Association for Chemoreception Sciences (member) Berendse HW Society for Neuroscience (member) Berendse HW Dutch Neurofederation (member) Berendse HW Dutch Society of Neurology (member) Boomsma DI KNAW Anxiety & Depression Attention & Cognition Addictive Behavior Castelijns JA Dutch Society of Head and Neck Radiology (chairman) White Matter Disease Castelijns JA Consilium Radiologicum (member) White Matter Disease Castelijns JA Medische Specialisten Registratie Commissie (member) White Matter Disease Castelijns JA European Society of Head and Neck Radiology (member) White Matter Disease Cohen-Kettenis P International Academy of Sex Research Affliated Research Cohen-Kettenis P World Professional Organisation for Transgender Health Affliated Research Dam AMW van Dutch Neurofederation (member) White Matter Disease Dam AMW van EU COST action BM3103 "Inflammation in Brain Disease (member) White Matter Disease 129

132 Dijkstra CD Glia Network Netherlands (chair) White Matter Disease Dijkstra CD Bestuur Rathenau Instituut (member) White Matter Disease Dijkstra CD Council International Society of Neuroimmunology (member) White Matter Disease Dijkstra CD COGEM commissie genetische modificatie (member) White Matter Disease Dijkstra CD Nederlands Tijdschrift van Geneeskunde (member) White Matter Disease Drukarch B Dutch Pharmacological Society Drukarch B Dutch Neurofederation Elsen P van den Dutch Society for Pathology (member) White Matter Disease Elsen P van den Dutch Society for Immunology (member) White Matter Disease Foncke EMJ Dutch Society of Neurology (member) Foncke EMJ Movement Disorder Society (member) Geurts JJG MAGNIMS (member Think Tank) White Matter Disease Geurts JJG Werkgroep verouderingsziekten LUMC/VUmc (member) White Matter Disease Geurts JJG Scientific Advisory Board Stichting MS Research White Matter Disease Geurts JJG Committee for Scientific Research (CWO) White Matter Disease Geurts JJG Interfaculty Project Group Imaging and pathology of neurodegeneration White Matter Disease Geurts JJG Commissie voor Wetenschappelijk Onderzoek, MAGNIMS (member) White Matter Disease Geurts JJG Adviescommissie MAGNIMS inzake nieuwe research initiatieven (member) White Matter Disease Geurts JJG Werkgroep verouderingsziekten LUMC/VUmc (member) White Matter Disease Geurts JJG Lid MAGNIMS (Magnetic Resonance in MS) multicenter consortium White Matter Disease Geurts JJG Wetenschappelijke Adviesraad Stichting MS Research White Matter Disease Geurts JJG Commissie voor Wetenschappelijk Onderzoek (CWO) van de Neuroscience Campus Amsterdam White Matter Disease Geurts JJG Member van de GM Study Group White Matter Disease Heuvel OA van Committee member program Depression & Anxiety, den Neuroscience Campus Amsterdam Anxiety & Depression Heuvel OA van Committee member Committee Scientific Activities (CWA), den Dutch Society for Psychiatry (NVvP) Anxiety & Depression Heuvel OA van Committee member preselection NWO-MaGW Open den Competition Anxiety & Depression Heuvel OA van den Organization for Human Brain Mapping (OHBM) Brain Imaging Heuvel OA van International College of Obsessive Compulsive Spectrum den Disorders (ICOCS) Anxiety & Depression Heuvel OA van den Society for Neuroscience (SfN) Brain Imaging Hoogendijk WJG Gezondheidsraad (permanent member) Anxiety & Depression Hoogendijk WJG NWO/ZonMw VENI committee Anxiety & Depression Jakobs C President of the Society for the Study of Inborn Errors of Metabolism White Matter Disease Jakobs C Wetenschapscommissie van de Nederlandse Vereniging voor Klinische Chemie White Matter Disease Jakobs C Scientific Advisory Board of Paediatric Neurotransmitter Disease Association White Matter Disease Jakobs C President of the International Organizing Committee of the International Congress of Inborn Errors of Metabolism White Matter Disease Killestein J NABINMS Steering group (member) White Matter Disease Knaap MS van der Board of the European Society of Magnetic Resonance in Neuropediatrics White Matter Disease Knaap MS van der Commissie Winklermedaille Nederlandse Vereniging voor Neurologie White Matter Disease Knaap MS van der Medical and scientific advisory board van de United Leukodystrophy Foundation White Matter Disease Knaap MS van der Prichard Award committee, International Child Neurology Association White Matter Disease Knaap MS van der Werkgroep ter Bestudering van Somatische Oorzaken van Zwakzinnigheid White Matter Disease Knaap MS van der Wetenschappelijke Adviesraad Vereniging voor Kinderen met Stofwisselingsziekten White Matter Disease Knaap MS van der Koninklijke Nederlandse Akademie van Wetenschappen White Matter Disease 130

133 Kooyk Y van Dutch Society of Immunology (chair) White Matter Disease Kooyk Y van Subgroup of Consortium for functional Glycomics (chair) White Matter Disease Kooyk Y van Board member of Dutch Society of Immunology (NVVI), White Matter Disease Kooyk Y van Head subgroup Immune recognition of glycans in Functional Glycomics consortium White Matter Disease ( Kooyk Y van Committee VENI, ZON-MW White Matter Disease Kooyk Y van Dutch Society of Immunology (chair) Brain Disease Mechanism Kooyk Y van Subgroup of Consortium for functional Glycomics (chair) Brain Disease Mechanism Kooyk Y van Scientific Board member KWF Brain Disease Mechanism Kooyk Y van Scientific Board member Aidsfoundation Brain Disease Mechanism Lambalk CB Member of advisory board of Affliated Research Lambalk CB Member Expert panel: Fonds Wetenschappelijk Onderzoek, FWO Belgium Affliated Research Lambalk CB Member of the board of the Netherlands Network for Fertility preservation (NNF) Affliated Research Lambalk CB Member of the scientific board of the VU research institute NeuroScience Campus Amsterdam Affliated Research Lambalk CB Member of the International advisory board of ESHRE Affliated Research Lambalk CB Chair of Dutch Nationwide Infertility Registry (LIR) Affliated Research Lambalk CB Board member Dutch Endocrine Society (NVE) Affliated Research Lambalk CB Lammertsma, A.A. Lammertsma, A.A. Lammertsma, A.A. Lammertsma, A.A. Lammertsma, A.A. Lammertsma, A.A. Lammertsma, A.A. Lammertsma, A.A. Lammertsma, A.A. Lammertsma, A.A. Lammertsma, A.A. Lammertsma, A.A. Lammertsma, A.A. Lammertsma, A.A. Member of the ESHRE special interest group Reproductive Endocrinology Academy for Molecular Imaging Dutch Society of Biophysics Dutch Society of Clinical Physics Dutch Society of Nuclear Medicine European Association of Nuclear Medicine European Society of Molecular Imaging European Society of Neuropsychopharmacology International Society of Cerebral Blood Flow and Metabolism Member Board Dutch Commission on Radiation Dosimetry Member Board Dutch Society of Clinical Physics Member IFAC BIOMED Technical Committee New York Academy of Sciences Society of Nuclear Imaging in Drug Development Society of Nuclear Medicine Affliated Research Brain Imaging Anxiety & Depression Brain Imaging Anxiety & Depression Brain Imaging Anxiety & Depression Brain Imaging Anxiety & Depression Brain Imaging Anxiety & Depression Brain Imaging Anxiety & Depression Brain Imaging Anxiety & Depression Brain Imaging Anxiety & Depression Brain Imaging Anxiety & Depression Brain Imaging Anxiety & Depression Brain Imaging Anxiety & Depression Brain Imaging Anxiety & Depression Brain Imaging Anxiety & Depression Brain Imaging Anxiety & Depression 131

134 Mansvelder HD Member Young Academy. KNAW Photonics & Life Cell Imaging Drugs Screening & Therapy Design White Matter Disease Attention & Cognition Addictive Behavior Systems Biology of the Synapse Penninx BWJH Member Young Academy. KNAW Anxiety & Depression Penninx BWJH Member of committee International Policy KNAW Anxiety & Depression Penninx BWJH Member of selection committee Dr. Hendrik Muller Award KNAW voor Gedrags- en Maatschappijwetenschsappen Anxiety & Depression Penninx BWJH Member of jury Heineken Young Scientists Award, KNAW Anxiety & Depression Penninx BWJH Member of Scientific Committee LifeLines Study Anxiety & Depression Penninx BWJH Board Member Psychiatric Epidemiology Section, European Association of Psychiatry Anxiety & Depression Penninx BWJH Committee member VIDI committee, NWO Anxiety & Depression Polman CH Various Boards MS International Federation (MSIF) Medical Advisory Board, Management Committee, Sylvia Lawry White Matter Disease Centre (member) Polman CH International Medical & Scientific Board of the MSIF (deputy chairman) White Matter Disease Polman CH Various Boards / Committees US National MS Society (NMSS), Chair Clinical Trial Advisory Board (member) White Matter Disease Polman CH European Federation of Neurological Societies (EFNS) Panel on Neuroimmunology and other European WG (member) White Matter Disease Polman CH Research programs Advisory Committee US National MS Society (member) White Matter Disease Polman CH NABINMS Steering Group (member) White Matter Disease Posthuma D Reijerkerk A De Jonge Akademie - KNAW Dutch Endothelial cell Biology Society (founder and vicechair) Integrative Analysis & Modeling White Matter Disease Reijerkerk A BBBNedworks (treasurer) White Matter Disease Rozemuller JM Member committee topnwo Rozemuller JM Board member/plv. Chair Nederlandse Vereniging voor Neurophatologie Rozemuller JM Advisory committee overhead voor prionziekten Rozemuller JM Member (neuropahtologist) Brain Network Europe Rozemuller JM Nederlandse Vereniging voor Pathologie Rozemuller JM Nederlandse Vereniging voor Kinderpathologie Rozemuller JM Board member Vrienden EuroCNS Salomons GS Voorzitter Vereniging tot bevordering onderzoek Erfelijke Stofwisselingsziekten in het Nederlandse taalgebied White Matter Disease Salomons GS Corresponding member of the Society for the Study of Inborn errors of Metabolism White Matter Disease Salomons GS Werkgroep ter Bestudering van Somatische Oorzaken van Zwakzinnigheid White Matter Disease Salomons GS Landelijke overleg DNA diagnostiek White Matter Disease Scheltens Ph NVvN, AAN, IPA Smit JH European Survey research Organisation (ESRA) Anxiety & Depression Smit JH European Methodology Association (EMA) Anxiety & Depression Smit JH Society for Longitudinal Research (Longview) Anxiety & Depression Stam CJ Dutch Society for Neurology Stam CJ Dutch Society for Clinical Neurophysiology Stam CJ Research Council for Health of the Academy of Finland Teunissen CE NUBIN (coordinator) White Matter Disease Teunissen CE Human Proteome Organization (HUPO) Clinical biomarker committee (member) White Matter Disease Teunissen CE BioMS-eu. Consortium for Biomarker research in Europe (general manager) White Matter Disease Teunissen CE International advisory board Innogenetics (member) White Matter Disease 132

135 Uitdehaag BMJ Dutch Society of Neurology (member of the board) White Matter Disease Uitdehaag BMJ Quality Committee Dutch Society of Neurology (chairman) White Matter Disease Uitdehaag BMJ Dutch Society of Epidemiology (member) White Matter Disease Uitdehaag BMJ Dutch Society of Health Technology Assessment (member) White Matter Disease Uitdehaag BMJ Scientific Committee of the Dutch MS Research Foundation (member) White Matter Disease Uitdehaag BMJ ECTRIMS council (member) White Matter Disease Uitdehaag BMJ Cochrane Neurological Network (member) White Matter Disease Uylings HBM New York Academy of Sciences Uylings HBM Scientific Advisory Board Croatian Inst. Brain Research, Zagreb, Croatia Valk P van der BDIAP British division Int. Ac. Of pathology (chair) White Matter Disease Valk P van der Dutch Society of Pathology (member) White Matter Disease Valk P van der Dutch Society of Neuropathology (member) White Matter Disease Valk P van der European Society of Pathology (member) White Matter Disease Valk P van der Committee of Pathological Society of Great Britain and Ireland (member) White Matter Disease Valk P van der European Association NeuroOncology (member) White Matter Disease Veltman DJ Organization for Human Brain Mapping (OHBM) Brain Imaging Veltman DJ International Society for Neuroimaging in Psychiatry (ISNIP) Brain Imaging Veltman DJ International College of Obsessive Compulsive Spectrum Disorders Anxiety & Depression Verweij CL Inflammation Network Netherlands (member) White Matter Disease Verweij CL Steering committee EU-AUTOCURE (member) White Matter Disease Verweij CL European association for Predictive, Preventive & Personalized Medicine (EPMA) White Matter Disease Verweij CL Research Council Molecular Medicine (member) White Matter Disease Verweij CL ZONMW VENI review committee White Matter Disease Verweij CL CTMM TRACER management team White Matter Disease Vies SM van der Royal Dutch Chemical Society (board member) Vies SM van der Biochemical Society (UK) Vies SM van der Society for Microbiology (UK) Vies SM van der Federation of European Biochemical Societies (FEBS) Vies SM van der Netherlands Biotechnology Society (NBV) Vies SM van der International Advisory Board : Bettencourt Foundation : Programme Frontiers du Vivant Visser PJ NVvE Vrenken H Commissie voor Wetenschappelijk Onderzoek, MAGNIMS (member) White Matter Disease Vrenken H Adviescommissie MAGNIMS inzake nieuwe research initiatieven (member) White Matter Disease Vrenken H ISMRM White Matter Study Group Steering Committee (member) White Matter Disease Vries HE de EU COST action BM3103 "Inflammation in Brain Disease (chair of the workgroup) White Matter Disease Vries HE de Scientific organizing consortium of the annual International BBB Symposia (member) White Matter Disease Vries TJ de Society for Neuroscience Addictive Behavior Vries TJ de European Behavioural Pharmacology Society Addictive Behavior Vries TJ de Werf YD van der Werf YD van der Wetenschappelijke adviesraad (WAR) Hersenstichting Nederland De Jonge Akademie, in the Royal Academy of Arts and Sciences Member executive committee International Society for Behavioural Neuroscience (ISBN), Addictive Behavior Brain Imaging Attention & Cognition Brain Imaging Attention & Cognition Wilhelmus MMM Dutch Neurofederation 133

136 Peer-reviewed journals or series that have been initiated by the institute Investigator journals or series that have been initiated by the institute Program Mansvelder HD Special issue Frontiers in cellular neuroscience, GABA signalling Photonics & Life Cell Imaging Drugs Screening & Therapy Design White Matter Disease Attention & Cognition Addictive Behavior Systems Biology of the Synapse Special professors Investigator Department Title Program Droës RM H&V Gen Psychosociale huplpverlening bij dementie Geurts JJG Geurts JJG Neale Anatomy & Neuroscience Anatomy & Neuroscience Biological Psychology Honorary Senior Lecturer, UCL Inst. Of Neurology, dept. Rehabilitation and brain Repair, University College London, UK Adjunct Associate Professor Dept. Physiology and Pharmacology, Hotchkiss Brain Institute, University of Calgary, Canada Statistical Methodology in Behavorial Genetics White Matter Disease White Matter Disease Addictive Behavior Scheltens Ph Neurology Honorary Professor UC London Selkoe D Harvard Medical School Eredoctoraat ter ere Dies VU Someren EJW van Uylings HBM Verhaagen J Vries TJ de Integrative Neurophysiology, FALW Anatomy & Neuroscience, VU University, Medical Center Molecular and Cellular Neurobiology Molecular and Cellular Neurobiology Human brain activity of sleep, resting state and vigilance Functional human neuroanatamy Bijzonder Hoogleraar Strategisch Hoogleraar Brain Imaging Addictive Behavior 134

137 Appendix 5: Societal impact a) Social-cultural relevance Memberships of an advice council in the public field Investigator Description Program Amor S. Ethical comittee for MS and Parkinsons Brain Bank - UK White Matter Disease Barkhof F. PONUR Werkgroep positioning Universitaire Radiologie White Matter Disease Beek JHGM van Member Internal Advisory Committee of the Netherlands Integrative Analysis & Consortium for Systems Biology Modeling Berendse HW Research Advisory Panel of the Dutch Parkinson s Disease Society Berendse HW Board Member Nederlandse Werkgroep Bewegingsstoornissen Berendse HW Advisory Board Anosmie Vereniging Nederland Boomsma DI Gezondheidsraad Anxiety & Depression Attention & Cognition Addictive Behavior Boomsma DI Bestuur Avond van de Wetenschap en Maatschappijz Anxiety & Depression Attention & Cognition Addictive Behavior Cohen-Kettenis PT ZonMw program Geestkracht Affliated Research Cohen-Kettenis PT Wetenschappelijke adviesraad van de Vereniging AOS Nederland (androgeen ongevoeligheidssyndroom) Affliated Research Dijkstra CD Glia Network Netherlands (Chair) White Matter Disease Dijkstra CD Bestuur rathenau Instituut (member) White Matter Disease Dijkstra CD Council International Society of Neuroimmunology (member) White Matter Disease Dijkstra CD Commissie van Wijzen, advies commissie besteding FES gelden (member) White Matter Disease Drent ML Member of the Dutch MEN 1 Study Groep Affliated Research Drent ML Member of the Dutch MEN 1 Study Groep Affliated Research Geurts JJG Commissie van Aanbeveling Veritas Forum White Matter Disease Geurts JJG. Wetenschappelijk directeur Stichting Brein in Beeld White Matter Disease Heutink P Member Scientific Advisory Board Prinses Beatrix Fonds Heutink P Member Scientific Advisory Board Foundation Plan Alzheimer (France) Heutink P Board member Europ. Society of Human Genetics (ESHG) Heutink P Board member Dutch Society of Human Genetics (NVHG) Hoogendijk WJG Member advisory board Nederlandse Hersenstichting Anxiety & Depression Knaap MS van der Medical and scientific advisory board van de United Leukodystrophy Foundation White Matter Disease Knaap MS van der Member of the Scientific Advisory Board of the Vereniging voor Kinderen met Stofwisselingsziekten White Matter Disease Kooyk Y van Member of the scientific Advisory Board Twincore, Center for Brain Disease Experimental and Clinical Infection Res. GmbH, Hannover Mechanism Kooyk Y van Member of the Scientific Advisory Board Infection Institute, Brain Disease Taiwan Mechanism Representative of Dutch Society of Immunology and Kooyk Y van Redactie Immunologisch a bi-annual Newspaper to Brain Disease promote Immunology within the general public in The Mechanism Netherlands. Rozemuller AM RIVM advise over Prionziekten in Nederland S Vies SM van der Advisory Committee NWO Rubicon Program (Chairman) Scheltens Ph VIDI, AGIKO, klinische Fellow ZONMW Scheltens Ph Raad van Toezicht Hersenstichting Scheltens Ph Stuurgroep Ketenzorg Dementie Scheltens Ph SAB JPND Scheltens Ph SAB Plan Alzheimer 135

138 Schoffelmeer ANM Advice council Stichting 12 Stappen Addictive Behavior Smit AB NIN, scientific advisory board nvt Smit AB Voorzitter Neurofederatie nvt Stam CJ Lid wetenschappelijke adviesraad Nationaal Epilepsie Fonds (NEF) Uylings HBM Member steering committee for field of Neurocomputation research in The Netherlands within the framework of the International Neuroinformatics Coordinating Facility (INCF) Valk P. van der Committee legal and ethical aspects of Royal Academy of Arts and Sciences (member) White Matter Disease Vies SM van der Board member Royal Ducth Chemcial Society (KNCV) Vies SM van der Lid redactieraad tijschrift C2W, C2W Life Science & C2W Medicine Visser PJ Steering Committee Jumpahead/JPND Vries JT de Wetenschappelijke adviesraad (WAR) Hersenstichting Nederland Addictive Behavior Indications in a directive, protocol or policy note Investigator Description Program Beek JHGM van I contributed to the Roadmap of the Virtual Physiological Human European Network of Excellence funded under FP7, published in Phil Trans Royal Soc A, as well as to the update to the Roadmap Berendse HW Lid centrale werkgroep multidisciplinaire richtlijn ziekte van Parkinson Integrative Analysis & Modeling Pijnenburg YAL Zichtbare Zorg VWS Pijnenburg YAL Ketenzorg dementie Rozemuller SM WIP Richtlijnen Prionziekten Contributions, based on research, to post initial education Investigator Description Amor S. Mutiple sclerosis pathology preceptroship teaching course White Matter Disease Barkhof F, Groot V de, Killestein J, Oosten BW van, Polman C.H, Uitdehaag BMJ Berg, W.J.D. van de Geus JCN de Hoogendijk WJG MS Masterclass 6th ONWA Course Morphometry & Stereology. Organizer and lecturer course Functional Neuroanatomy for Ph.D. students and postgraduates of ONWAR at VUmc, Amsterdam, March 2010 VU-AMS workshop introductory (4x yearly) to VU-AMS user community (mostly PhDs) De Doelen: Ontwikkelingen in de Geneeskunde Nascholing huisartsen regio Rotterdam. White Matter Disease Anxiety & Depression Anxiety & Depression Hoozemans JJM Masters Neuroscience college 10 okt 2010 Penninx BWJH Master students biomedical sciences, VU University - Brain Disease Research master course Mental Health Mechanism Penninx BWJH Postdoctoral Education Epidemiology (POE), VUmc - Brain Disease Psychiatric epidemiology Mechanism Rozemuller AM, Masters Neuroscience Neuropathology of Dementia 21 okt Hoozeman JJM 2010 Rozemuller AM, Hoozeman JJM ONWA cursus Dementia 26 en 29 maart 2010 Scheltens Ph Dementie Update (jaarlijks) Uylings HBM Organizer and lecturer course Functional Neuroanatomy for PhD students and postgraduates of ONWAR at VUmc, Amsterdam, March 2010 Uylings HBM Human brain dissection practicals at postacademic PAOG course of VU-University medical center Practical Neuroanatomy and Brain Imaging macroscopic neuroanatomy June

139 Uylings HBM Lectures and microscopic exercises at Ph.D./peridoctoral course Karolinska Institute (Stockholm,Sweden) Human Neuroanatomy: From Development to November 2010 Uylings HBM Human brain dissection practicum in AIOS Neurology Course, November 2010 Visser PJ Teaching in post-doctoral training course Psychogeriatrics Voorn P Lecturer course Functional Neuroanatomy for PhD students and postgraduates of ONWAR at VUmc Amsterdam, March 2010 Voorn P Human brain dissection practicum in AIOS Neurology Werf YD van der Course, November 2010 postdoctoral Specialization Clinical Neuropsychologist (RINO group) Brain Imaging Media attention Investigator Description Program Bartels M VPRO-Labyrint- Met Geluk Geboren [Born to be Happy] Anxiety & Depression Bartels M ZIN-geluksdossier Anxiety & Depression Beek JHGM van Radio 4 interview not on science Integrative Analysis & Modeling Berendse HW Contribution to NTR TV program Pavlov Boomsma DI Margriet ( ): Genen en Gedrag Anxiety & Depression Attention & Cognition Addictive Behavior Boomsma DI NCRV gids, BBC reportage tweelingen Anxiety & Depression Attention & Cognition Addictive Behavior Cohen-Kettenis PT Teleac Affliated Research Cohen-Kettenis PT NBC news Affliated Research Cohen-Kettenis PT Psychopraktijk (tijdschrift) Affliated Research Cohen-Kettenis PT Brandpunt Affliated Research Cohen-Kettenis PT Volkskrant ( en Affliated Research Drukarch D Interview for Parkinson Nieuwsbrief a publication of the Stichting Internationaal Parkinson Fonds Flier WM van der Interview Radio 1 nav promotie Nelleke Tolboom; 13 feb Geurts JJG Wetenschapscommentator BNN en 3FM White Matter Disease Geurts JJG Columnist EOS Psyche en Brain White Matter Disease Geurts JJG Columnist MSWeb White Matter Disease Geus JCN de Radio 1: De Gids ( ): Dik worden zit in de genen Anxiety & Depression Attention & Cognition Addictive Behavior Geus JCN de Wereldomroep ( ): Anxiety & Depression Attention & Cognition Addictive Behavior Heutink P Noorderlicht radio Heutink P Radio 1 journaal Hoogendijk WJG VARA: Nieuwslicht; aflevering podiumangst 2010 Anxiety & Depression Hoogendijk WJG VPRO: Labyrinth; aflevering Met geluk geboren, 2010 Anxiety & Depression Hoogendijk WJG Boek: Kijken in de ziel door Coen Verbraak (in 2009 op televisie bij de RVU) Anxiety & Depression Knaap MS van der Interview over hematopoietische stamceltransplantatie, uitgezonden op TV White Matter Disease Linkenkaer-Hansen K VARA s Nieuwslicht. I hosted Menno Bentveld and Javier Guzman for their special episode on Alcohol and the brain Integrative Analysis & Modeling Middeldorp CM EOS magazine ( ): Depressie: van vader op zoon? Anxiety & Depression Attention & Cognition Addictive Behavior Posthuma D Interview NCRV TvGids Pavlov, nov 2010 Integrative Analysis & Modeling Posthuma D National List of 400 most succesfull women under 39 years, - Integrative Analysis & Dutch Popular magazine, okt 2010 Modeling 137

140 Posthuma D TV, Teleac Scienceflash , on ScienceLive - Project Integrative Analysis & in Science Center Nemo Modeling Posthuma D National newspaper Het Parool, , Interview, - Integrative Analysis & ScienceLive Project Science Center Nemo Modeling Posthuma D Kennislink, , on ScienceLive Project in Science Integrative Analysis & Center Nemo Modeling Posthuma D National Newspaper Spits, , on Genes and Integrative Analysis & Intellgence Modeling Posthuma D Radio 1 De praktijk, , on ScienceLive - Project in Integrative Analysis & Science Center Nemo Modeling Posthuma D Radio interview extra edition Amsterdam Radio on Integrative Analysis & Intelligence and Genes, August 5, 2010 Modeling Posthuma D Interview national newspaper Volkskrant de Verdieping on Integrative Analysis & Freedom. April 2010 Modeling Interview for Dutch book Wat Cognitiewetenschappers Posthuma D bezielt ( What drives cognition scientists? ) onder redactie Integrative Analysis & van P Hagoort en J van Benthem, The Netherlands Scientific Modeling Organisation (NWO), The Hague. Rozemuller JM 4 vermeldingen van oratie 18 juni in kranten/bladen (o.a Ned. dagblad) Rozemuller JM Tracer: Vermelding/interview oratie Scheltens Ph Rondom opening Alzheimercentrum 28-09, oa NOS journaal Scheltens Ph Interview in NRC bijlage het Brein, dec 2010 Scheltens Ph Idem in Telegraaf september en december 2010 Smit AB Presentatie Conferentie Alcohol en Jeugd 22 april 2010 Addictive Behavior Smit AB Voorlichting Gemeente Ouder-Amstel, Alcohol en uw Kind, 30 september 2010 Addictive Behavior Smit AB Presentatie Alcohol en Jongeren, STAP congres, Addictive Behavior Someren EJW van Magazine, Consumentengids, Achtergrond, Uitgeslapen opstaan Attention & Cognition Someren EJW van Internet, National Geographic, NatGeo Newswatch, Does insomnia lead to brain loss? Brain Imaging Someren EJW van Internet, Science Daily, Science News, Losing Sleep, Losing Brain Brain Imaging Someren EJW van TV, Nederland 2 TELEAC, Focus, Alles op zijn tijd Attention & Cognition Someren EJW van Newspaper, Leids Dagblad, Regio, Leiden wordt de slaapstad van Nederland Brain Imaging Someren EJW van Newspaper, Parool, Amsterdam, Wie kort slaapt heeft andere hersenen Brain Imaging Someren EJW van Magazine, Vrij Nederland, Het Leven, Slapeloosheid Anxiety & Depression Someren EJW van Radio, Radio 5 Max, Wekker Wakker, Slapeloosheid Anxiety & Depression Someren EJW van Newspaper, Volkskrant VK Banen, Werk, Even de ogen dicht Anxiety & Depression Someren EJW van Newspaper, Die Zeit, Reisen, Mehr Licht! Attention & Cognition Someren EJW van Internet, Kennislink, Lachen om de jetlag Attention & Cognition Someren EJW van TV, AT5, Amsterdam Inc, Okura helpt bij jetlag Attention & Cognition Someren EJW van Internet, Amsterdam Inc,, Okura helpt bij jetlag Attention & Cognition Someren EJW van Magazine, Synaps VUmc Science Magazine, Cooperation, Goede nachtrust voor iedereen Anxiety & Depression Someren EJW van Internet, De Pers, Vraagteken, Functie van slaap Brain Imaging Someren EJW van Newspaper, De Pers, Wetenschap, Functie van slaap Brain Imaging Someren EJW van Internet, De Pers, Psychologie, Dutje doen. Schoonheidsslaapje maakt echt mooi Affliated Research Someren EJW van TV, VRT 1, Ook getest op mensen, Slapend leren Attention & Cognition Someren EJW van Internet, Ooit gemist, Ook getest op mensen, Slapend leren Attention & Cognition Someren EJW van Internet, New York Times, Health, The Vanishing Mind: Giving Alzheimer s Patients Their Way, Even Chocolate Stam CJ, Hillebrand A Synaps: /Synaps_74_juli-2010.pdf Brain Imaging; Visser PJ Interview at Romanian television Vries ALC de Artsennet Stel-puberteit-uit-bij-genderdysfore-jongeren.htm Affliated Research Vries ALC de BNN Affliated Research Vries ALC de Belgie 1 radio Affliated Research Vries ALC de De wereld draait door Affliated Research 138

141 Vries ALC de Affliated Research Vries ALC de - genderdysfore-jongerenhebben-baat-bij-uitstellen-puberteit/ Affliated Research Vries ALC de cle&article=35922&itemid=79 Affliated Research Vries TJ de Bijdrage TV uitzending Vara s Nieuwslicht (interview) Addictive Behavior Werf UD van der Television broadcast NTR Helder Attention & Cognition Werf UD van der Volkskrant Dossier: VkAkademie/article/detail/ /2010/12/17/De-Jonge- Akademie-Waarom-hebben-we-slaap-nodig.dhtml ; en: Attention & Cognition Wilhelmus MMM Ontrafeling van Alzheimer een stapje verder. Publication of the Hersenstichting Nederland by John Ekkelboom on the work of Micha Wilhelmus following his appointment as Hersenstichting Fellow. Publicated on NU.nl, gezondheidsnet, medinews, ONVZ, zoekdokter, hersencognitie, gezondheidskrant, tracer, hetnieuws, hersenstichting, newsfrog, headlinez, MSN, etc. Wilhelmus MMM Interview for Hersenmagazine a publication of the Hersenstichting Nederland. Perceptible impact on public informing and/or authoritative websites Investigator Description Program Boomsma DI Boomsma DI Boomsma DI Boomsma DI Nu Gezondheid: ; Gen bepaalt laag geboortegewicht en diabetes Nu Gezondheid ; Genen zorgen voor extra kilo s Trouw: : Genen en gewicht Gezonderworden.nl: ; Ook ADHD bij volwassenen is genetisch bepaald Anxiety & Depression Attention & Cognition Addictive Behavior Anxiety & Depression Attention & Cognition Addictive Behavior Anxiety & Depression Attention & Cognition Addictive Behavior Attention & Cognition Geurts JJG The Free Will Illusion; Veritas forum White Matter Disease Geurts JJG HOVO kerstlezing: Ik zie wat jij denkt White Matter Disease Geurts JJG Eindeloos bewustzijn White Matter Disease Geurts JJG VU-podium lezing: Bewustzijn. White Matter Disease Geurts JJG Ned. Vereniging voor Psychiatrie: Ik zie wat jij denkt! White Matter Disease Geus JCN de Webregio.nl: ; Obesity & WHR genes Anxiety & Depression Attention & Cognition Addictive Behavior Heutink P Alzheimer cafe Heutink P Frankeland Parkinson cafe Website of he NESDA study, provides Dutch Penninx BWJH Anxiety & Depression abstracts of all publishes papers. Penninx BWJH ; Website with news about depression and anxiety, a collaboration with Ned/KAD and the Trimbos Inst. Anxiety & Depression Smit AB Neurocypres website EU Public Awareness Systems Biology of the Synapse Smit AB Synsys website EU Public Awareness Systems Biology of the Synapse Someren EJW van Someren EJW van Attention & Cognition Stam CJ, Douw L, Haan W Vies SM van der Hersenweb. Prometheus/Bert Bakker, Amsterdam 2010 (Nederlandstalig populair wetenschappelijk boek waarin netwerk onderzoek van VUmc wordt beschreven voor breed publiek. Klokhuis Vragendag (Kinderen stellen vragen aan wetenschappers, in NEMO) 139

142 Perceptible impact on public opinion and/or political decision-making Investigator Description Program Beek JHGM van Cohen-Kettenis PT Kooyk Y van Smit AB Faculty Member of Faculty of 1000 Biology: several evaluations published on BioMed Central website Chair of the Diagnostic and Statistical Manual for Mental disorders ( DSM-5) subworkgroup on Gender Identity Disorders of the American Psychiatric Association Representative of Dutch Society of Immunology and Redactie Immunologisch a bi-annual newspaper to promotoe Immunology with the general public of the Netherlands Sysgenet cost action in EU Integrative Analysis & Modeling Affliated Research White Matter Disease Systems Biology of the Synapse b) Technical or economic impact Memberships of an advice council in the commercial field Investigator Description Program Drent ML Member of the National Somavert/Acromegaly Board, Pfizer Affliated Research Drent ML Member of the International KIMS Board, Pfizer Affliated Research Scheltens Ph Member advisory board of Genentech, Danone Research, Nutricia, Roche, Novartis, Pfizer, Lundbeck, Forbion Visser PJ Member advisory board Bristol-Myers Squibb Werf YD van der Consultant nascholing Beeldvorming MS & Cognitie sponsored by Merck Serono B.V. White Matter Disease Attention & Cognition Patent applications Investigator Description Program Cover KS, Lagerwaard FJ, Senan S Hoogendijk EWJG, Smit AB Kesteren RE van, Verhaagen J, Smit AB Kesteren RE van, Verhaagen J, Smit AB Reijerkerk A, Vries HE de Reijerkerk A, Vries HE de Unger WWJ, Kooyk Y van Vies SM van der, Hoozemans JJM Color Intensity Projections: Current application is summarizing a series of angiography images as a single color image with time information encoded. A recent independent assessment of the technique was very encouraging (Strother CM et al. Am J Neuroradiol 2010;31: ) A license agreement with a major medical imaging company is nearly ready to sign. WO 2009/ A1 Means and methods for typing a cell isolate of an individual suffering from a psychiatric disorder or at risk or suffering from major depression P PCT/US - Polypeptides involved in neuronal regeneration-associated gene expression ( ) Polypeptides involved in neuroregeneration promoting properties of olfactory ensheating glia MicroRNAs as targets for blood-brain barrier modulation Myc-associated zinc finger protein as a target for bloodbrain barrier modulation Method for suppressing an immune response Measuring protein kinase activity in a cerebrospinal fluid comprises obtaining sample of cerebrospinal fluid, incubating the sample with ATP on an array of substance, and obtaining a detectable phosphorylation profile. Brain Imaging Systems Biology of the Synapse White Matter Disease White Matter Disease White Matter Disease 140

143 Appendix 6: Acquisition Neuroscience Campus Amsterdam GENERAL GRANTS Investigators Project Titel Grant Funding Funding Start End support Organization type Brussaard, AB ENC-Network (Erasmus EU Mundus Joint Doctorate) - EMJD Bartels M Verspreiding van onderzoeksresultaten onder de algemene Nederlandse bevolking door middel van de TWINFO ZonMw (disseminatie projecten) Advanced Technology Programs: BRAIN IMAGING Investigators Project Titel Grant support Someren EJW van Veltman DJ, Heuvel OA van den, Cath DC Cover KS Remt verbetering van cortisol- en slaapritmen het atrofiëren van de mediale temporaalkwab bij ouderen met Alzheimer s dementie? Neuroimaging in OCD: a family study. Feasibility study for a novel and clinically useful MRI sequence for image myelin in MS patients. The time-course of cognitive functioning and cerebral structure and functions in type 1 diabetes mellitus with and without microangiopathy Funding Organization Hersenstichting Nederland Hersenstichting Nederland Dutch Multiple Sclerosis Research European Foundation for the Study of Diabetes in samenwerking met Eli Lily and Company (EFSD/Lily). Funding type Start End Advanced Technology Programs: INTEGRATIVE ANALYSIS & MODELING Stam CJ (Coinvestigator) Investigators Project Titel Grant Funding Funding Start End support Organization type Linkenkaer- VU-CvB Financial matching to NWO Hansen K Incentive Scheme (Subsidiable VIDI) Posthuma D Towards an integrative theory of the genetically mediated neural substrates of ADHD NWO Posthuma D, Cornelisse LN Identification of synaptic gene networks in complex brain disorders using a Bayesian framework NWO

144 Advanced Technology Programs: PHOTONICS & LIFE CELL IMAGING Investigators Project Titel Grant Funding Funding Start End support Organization type Mansvelder HD, Groot ML Simultaneous photomanipulation and non-linear optical imaging of single synapses and neuronal networks in intact brain; NWOMiddelgroot investment ZonMW Investigators Project Titel Grant support Heuvel OA Neuroimaging in OCD: van den, a family study. Cath DC, Veltman DJ Brug, Bartels M Geus JCN de, Boomsma DI. Bartels M Middeldorp, CM Middeldorp CM, Boomsma DI Penninx BWJH Penninx BWJH, Boomsma DI Smit JH Someren EJW van Veltman DJ, Popma A, Doreleijers TH, Brink W van den Veltman DJ, Olff M, Brink W van den Genes and environment in obesogenic behavior: Exploring the relative importance of environmental and genetic factors on sedentary behavior and sleep duration during adolescence-a study in adolescent twins Determinants of Adolescent Exercise Behavior: Towards Evidence-Based Intervention The role of genes and environment in anxiety spectrum disorders Genetic influences on stability and change in psychopathology from childhood to your adulthood Completion of GWAS for the NESDA biobank Funds to hold the Genomics of Gene expression conference Sample accessibility for the NESDA Biobank NeuroSIPE project thermoregulation and vigilance Conditioning in juvenile delinquents The effect of endogenous and axogenous stimulation of the oxytocin system in PTSD patients Brain Disease Mechanisms: ANXIETY & DEPRESSION Funding Organization Hersenstichting Nederland World Cancer Research Fund Funding Start End type NIH NIH ZonMw (TOP) BBMRI-NL: Biobanking and Molecular Resources Research Infrastructure KNAW: Royal Netherlands Academy of Science and Arts BBMRI-NL STW NWO Mozaïeksubsidie NOW TOP subsidie

145 Boomsma DI Boomsma DI, Geus JCN de Geus JCN de NTR Biobank Sample Accessibility Human Tissue and Associated Metagenomics Biobank fenotypering cardiovasculair NWO:; BBMRI Pfizer NWO;; BBMRI Investigators Project Titel Grant support Berg, W.J.D. van de Dam AMW van, Lucassen PJ Drukarch, B, Wilhelmus MMM, Hoozemans JJM Flier WM van den Simon- Sanchez J Someren EJW van Teunissen CEm Jimenez CR Vies SM van der, Scheltens Ph Visser PJ Wilhelmus MMM Pijnenburg YAL The clinical relevance of alpha-synuclein pathology in Parkinson s disease Understanding selective vulnerability in Parkinson's disease; does a regionalspecific microglial expression profile determine stem cell responsivity, resistance to pathology or loss? The unfolded protein response and neuroinflammation in Parkinson s disease Hersenen&Cognitie: dementie Genoom brede associatiestudies en homozygotie mapping voor de ziekte van Parkinson in Nederlandse cohorten Implementatie Plan; Preventie van depressie en slaapstoornissen in een vroeg stadium van dementie: activatie van de biologische klok middels licht massaspectrometrisch e detectie van specifieke amyloid-beta peptide fragmenten in liquor in combinatie met patroon analyse Bayesian statistics and Bioinformatics for Biomarker validation using Biobanks in Alzheimer's Disease (B4AD) ; Exclusief NCA Risk prediction model for Alzheimer s disease Amyloid pathology in Alzheimer s disease is dependent on transglutaminasedriven conformational changes in amyloidbeta and apolipoprotein E. Late onset frontaal syndroom Brain Disease Mechanisms: NEURODEGENERATION Funding Organization Stichting Internationaal Parkinson fonds Stichting Internationaal Parkinson fonds Stichting Internationaal Parkinson Fonds Funding Start End type NWO PBF ZONMW Hersenstichting Nederland EuroTransBio Agentschap NL Bristoil-Myers Squibb Hersenstichting Nederland Hersenstichting Nederland

146 Brain Disease Mechanisms: WHITE MATTER DISEASE Investigators Project Titel Grant Funding Funding Start End support Organization type Mansvelder E-rare EU-FP HD Amor S Monocyte and Delta Crystallon macrophage microarrays Castelijns J High field MRI in MS Guerbet Castelijns J High field MRI in MS Noaber Dam AMW van, Baron W Elsen P van den Geurts JJG Tissue Transglutaminase in astrogliosis and oligodendrocyte differentiation: towards improved remyelination Monocyte dysfunction in MS The effect of natalixumab treatment on brain activity, using resting-state fmri MS Reserach MS Research Biogen Geurts JJG Staging lesions Stichting MS Research Geurts JJG, Vries HE de Groot V de, Teunissen CE Horssen J van Horssen J van Horssen J van Horssen J van Oppen P van Polman CH Polman CH Polman CH Polman CH, Petzold A, Geurts JJG Understanding neurodegeneration and moving towards neuroprotection in MS: from molecule to mind The best treatment strategy for fatiique Fellowship of the Dutch Foundation of MS Research on Reactive oxygen species in multiple sclerosis pathology: from source to solution BG00012: a novel therapeutic strategy to promote oligodendrocyte survival in MS pathogenesis Reactive oxygen species in MS pathology: from source to solution; Fellowship St. MS Research Effect van BG-12 op oligodendrocyten Depression in MS: effectiveness of webbased self-help treatment A genotyping prognostic tool to predict course of multiple sclerosis (MS), improve its management and personalize treatment Biomarkers for neurodegeneration SUMMIT cohort: Risk factors for progression in MS OCT and brain MRI abnormalities in MS Stichting MS Research ZonMw Stichting MS Research Biogen Idec Stichting MS Research Biogen Stichting MS Research Eurostars Particuliere gever National Multiple Sclerosis Society Private investor

147 Reijerkerk A, Vries HE de Reijerkerk A, Vries HE de Reijerkerk A Teunissen C, Khalis M, Fazekas F Unger WWJ, Kooyk Y van Unger W, Kooyk Y van Evaluation of targeted delivery in in vivo models for MS MicroRNAs in the brain vasculature, novel targets for MS treatment Novel MicroRNAs in the treatment of multiple sclerosis Fellowships for international visit. Biomarkers for axonmal damage and neurodegernation in MS Antigen specific inhibition of encephalitogenic T-cells by selective targeting of corticosteroid/antigen loaded liposomes to cervical lymph node dendritic cells Prednisolon/antigeengeladen liposomen te targeten naar DC- SIGN om autoreactieve T-cell responsen te remmen to-bbb, Leiden Stichting MS Research NGI Horizon Breakthrough, valorisation grant Eriwin Schroedinger Foundation Stichting MS Research Stichting MS Research Vrenken H LSF MerckSerono Vries HE de, t Hart Geurts JJG Vermeulen RJ Targeted treatment of multiple sclerosis phmri of functional reorganization following Rebif treatment , Normeringsen valideringsonderzoek C-BiLLT Stichting MS Research MercSerono Phelps Stichting Genes and the Brain: ATTENTION & COGNITION Investigators Project Titel Grant Funding Funding Start End support Organization type Boomsma DI, Geus JCN de Twin-family study of individual differences NWO FES Hulshoff Pol HE, Boomsma DI Kock CPJ de Someren EJW van Werf YD van der, Gog T van (EUR) Werf YD van der, Roelfsema P, Mansvelder HD Mansvelder HD in school achievement Functional neural network plasticity in adolescent twins and sibs Hersenstichting Nederland The role of sleep in children: opportunities for performance improvement Children s observational learning in relation to sleep. Samenwerkingsverban d NIN/VUmc/EUR. Slow Brain Oscillations of Sleep, Resting State and Vigilance subsidie ter ondersteuning van Summerschool NWO; Brain & Cognition: Integrated Approach Programs excellence HSN NWO National Initiative Brain and Cognition (FES) KNAW KNAW NeuroBasic (FES) FES Smit, AB NeuroBasic (FES) FES

148 Verhage, M NeuroBasic (FES) FES Meredith RM Aspasia NWO Genes and the Brain: ADDICTIVE BEHAVIOR Investigators Project Titel Grant Funding Funding Start End support Organization type Peters JL Elucidating and enhancing inhibitory memories to treat drug addiction NWO Genes and the Brain: SYSTEMS BIOLOGY OF THE SYNAPSE Investigators Project Titel Grant Funding Funding Start End support Organi-zation type Smit AB CEREBNET EU Groffen AJA Genetische oorzaak Prinses Beatrix Fonds van paroxysmale kinesigene dyskinesie en geassocieerde vormen van erfelijke epilepsie Kesteren RE Automated highresolution NWO van Smit, A.B. confocal microscopy for largescale cellular screening of neuronal disease-related genes and proteins Mansvelder HUNA HUNA HD Smit AB, Verhage M, Mansvelder HD Synsys: Synaptic Systems: dissecting brain function in health and disease" EU Verhage M EUROSPIN EU Meredith RM Aspasia NWO Meredith RM Meredith RM VIDI; From synaps to network: Role of glutamate receptors in early development of synaptic spine pathology underlying mental retardation VIDI; From synaps to network: Role of glutamate receptors in early development of synaptic spine pathology underlying mental retardation NWO NWO Affiliated research Investigators Project Titel Grant support Funding Organization Cohen- Neuroendocriene Hersenstichting Kettenis P, implicaties voor Nederland Kreukels BPC, cognitie van Lambalk CB blootstelling aan crosssekshormonen Funding Start End type

149 Cohen- Kettenis P, Kreukels BPC, Lambalk CB Drent ML Lambalk CB Sex steroids and cognition Uitkomsten na hypofysechirurgie bij patiënten met acromegalie en M. Cushing Metabolomic profiling with Near Infrared Absorption Spectronomy Nuts Ohra Novo-Nordisk ZonMw