Latest advances in the treatment of mesothelioma

Size: px
Start display at page:

Download "Latest advances in the treatment of mesothelioma"

Transcription

1 Latest advances in the treatment of mesothelioma Assoc Prof Thomas John Medical Oncologist, NHMRC Fellow Olivia Newton-John Cancer Research Institute 28 th March 2015 Disclosures Nil relevant Honoraria: Astra Zeneca, BMS, Roche, Merck Travel Grants: Boehringer Ingelheim, Roche, Astra Zeneca Advisory Boards: Pfizer, Astra Zeneca 1

2 Number Crude rate ASR Risk to age 75 1 in in 1,505 1 in in in 2,057 1 in 650 Risk to age 85 1 in in in in in in 259 Mean age Estimated number for 2014, 2015 and 2016 (c) The statistics Rate (per 100,000) Rate (per 100,000) Incidence males Mortality males Incidence females Mortality females Incidence males Mortality males Incidence females Mortality females Figure B18(a): Incidence and mortality ASRs (b,c) of mesothelioma, Figure B18(b): Incidence (2011) and mortality (2012) rates of mesothelioma, by age group (a) Based on IARC (2014) and WCRF & AICR (2007) (see Chapter 2). (b) The 2011 incidence data include estimates for NSW and the ACT. Mean age for 2011 incidence was calculated excluding NSW and the ACT (see Appendix F). Deaths registered in 2010 and earlier are based on the final version of cause of death data; deaths registered in 2011 and 2012 are based on revised and preliminary versions, respectively, and are subject to further revision by the ABS. ASRs were directly standardised to the Australian population as at 30 June Rates are expressed per 100,000 population. Cancer in Australia 2014 (c) The estimates for incidence are based on incidence data. The estimates for mortality are based on mortality data (see Appendix G). They are rounded to the nearest 10. Estimates less than 1,000 are rounded to the nearest 5. The estimates for males and females may not add to estimates for persons due to rounding. Sources: AIHW ACD 2011; AIHW NMD. 120 Cancer in Australia: an overview 2014 Progress is slow NSCLC 2004: EGFR mutations discovered 2012: Immunotherapy 2000: 2 nd line chemo NSCLC 1995: 1 st line chemo NSCLC : ALK rearrangements 2009: Maintenance chemo 1993 Mesothelioma 2015 Multiple negative Phase II studies 2003: 1 st line chemotherapy Mesothelioma 2

3 Carbone et al. CCR 2011 Robinson et al NEJM, 2005 Important Trials for 2015 Phase II/III Pemetrexed/Platinum +/-Bevacizumab as first line therapy in MPM Preliminary data presented from Phase II portion met criteria for continuing DCR at 6 months was 73.5% in the Bev arm compared to 43.2% in the control arm Likely to be presented at ASCO 2015 Phase I/II study of Pembrolizumab in MPM (Keynote- 028) Data presented at ESMO 2014 showed the target PDL-1 was expressed in 20% MPM Patients with strong PDL-1 expression had the poorest outcomes (i.e it is a predictive marker but also poor prognostic marker) This study will be presented at AACR next month 3

4 Immunotherapy Ribas NEJM, 2012 Immunotherapy predictive marker PD-L1 + PD-L1-4

5 Response to PD-1 inhibitors by PD- L1 expression in tumour Note bw 9-20% PD-L1 negative respond PD-1 inhibitors Do they work? Week 1 Week 6 Week 12 5

6 Progression-Free Survival (%) Kaplan-Meier Estimate of Progression-Free Survival by RECIST 1.1 (Central Review) a with Clinical Trial Assay Median, wks Rate, 12 wks Rate, 24 wks PS0 (n=49) % 13% PS1-49 (n=53) % 20% PS 50 (n=44) % 41% N at risk: PS0: Time in Weeks PS1-49: PS 50: PFS was significantly longer in patients with strongly (PS 50) PD-L1+ staining tumors compared to weakly positive (PS1-49) and negative (PS0) HR= % CI: 0.33,0.83 P=0.004 Data cut-off was December 31, a Evaluable patients were those patients in the training set with evaluable tumor PD-L1 expression. 6

7 PD-L1 in Mesothelioma Cedres et al. PLOS One 2015 Is there progress? Other trials Trial Pem/Cis +/- Cedirinib SS1P and Pentostatin + Cyclophos CAR T Cell Receptor Immunotherapy Adjuvant Iscomatrix/Tumor Lysate Vax adc1 Vax+Chemokine Mod Regimen Pemetrexed second line Erlotinib in MPM Mithramycin in chest cancers Allogeneic Tumor Cell Vaccine Intrapleural Gene Therapy for MPM Intrapleural measles Virus Therapy Proton beam RT Phase II I/II I/II I/II I/II II II II I I I Mesothelioma Trials on Cancer.Gov 7

8 Novel agents targeting mesothelioma 8

9 9

10 Novel solution for mir-15/16 construct delivery: Minicells or EngeneIC Delivery Vesicles (EDVs) 10

11 Targetable mutations.. Lynch et al. NEJM

12 Targetable mutations in mesothelioma Iacono et al JTO 2015 Guo et al Can Res

13 Targeting the NF2/Merlin pathway Shapiro et al. Sci Trans Med 2014 Where is the research heading? Globally individual centres have small patient numbers Number of new cases still rising, but still small Mesothelioma is not a priority for Pharma! Need for collaborative group trials 13

14 Clinical Development of Inhibitors of PD-1 in NSCLC Target Agent Molecule Company Development PD-1 Nivolumab- BMS Pidilizumab CT-011 Pembrolizumab MK-3475 Fully human IgG4 mab Humanized IgG1 mab Humanized IgG4 mab Bristol-Myers Squibb CureTech Merck Phase II, III multiple tumors Phase II multiple tumors Phase I-II,III AMP-224 Recombinant PD-L2- Fc fusion protein PD-L1 BMS Fully human IgG4 mab MedI-4736 MPDL-3280A Engineered human IgG1 mab Engineered human IgG1 mab GlaxoSmithKline Bristol-Myers Squibb MedImmune/AZ Roche-Genentech Phase I Phase I Phase I-II Phase II-III Adapted from J. Brahmer ASCO 2013, Leighl ASCO 2013 REVIEWS Antigen-presenting cell PDL1 or PDL2 PDL1 or PDL2 CD80 or CD86 CD80 or CD86 B7RP1 B7-H3 B7-H4 HVEM MHC class I or II CD137L OX40L CD70 + CD40 GAL9 Adenosine Peptide Cytokines (TGFβ, IL-1, IL-6, IL-10, IL-12, IL-18) T cell? PD1 CD28 CTLA4 ICOS?? BTLA KIR TCR LAG3 CD137 OX40 CD27 CD40L TIM3 A2aR Signal Figure 1 Multiple co-stimulatory and inhibitory interactions regulate T cell responses. Depicted are various ligandreceptor interactions between T cells and antigen-presenting cells (APCs) that regulate the T cell response to antigen (which is mediated by peptide major histocompatibility complex (MHC) molecule complexes that are recognized by the T cell receptor (TCR)). These responses can occur at the initiation of T cell responses in lymph nodes (where the major APCs are dendritic cells) or in peripheral tissues or tumours (where effector responses are regulated). In general, T cells do not respond to these ligandreceptor interactions unless they first recognize their cognate antigen through the TCR. Many of the ligands bind to multiple receptors, some of which deliver co-stimulatory signals and others deliver inhibitory signals. In general, pairs of co-stimulatoryinhibitory receptors that bind the same ligand or ligands such as CD28 and cytotoxic T-lymphocyte-associated antigen 4 (CTLA4) display distinct kinetics of expression with the co-stimulatory receptor expressed on naive and resting T cells, but the inhibitory receptor is commonly upregulated after T cell activation. One important family of membrane-bound ligands that bind both co-stimulatory and inhibitory receptors is the B7 family. All of the B7 family members and their known ligands belong to the immunoglobulin superfamily. Many of the receptors for more recently identified B7 family members have not yet been identified. Tumour necrosis factor (TNF) family members that bind to cognate TNF receptor family molecules represent a second family of regulatory ligandreceptor pairs. These receptors predominantly deliver co-stimulatory signals when engaged by their cognate ligands. Another major category of signals that regulate the activation of T cells comes from soluble cytokines in the microenvironment. Communication between T cells and APCs is bidirectional. In some cases, this occurs when ligands themselves signal to the APC. In other cases, activated T cells upregulate ligands, such as CD40L, that engage cognate receptors on APCs. A2aR, adenosine A2a receptor; B7RP1, B7-related protein 1; BTLA, B and T lymphocyte attenuator; GAL9, galectin 9; HVEM, herpesvirus entry mediator; ICOS, inducible T cell co-stimulator; IL, interleukin; KIR, killer cell immunoglobulinlike receptor; LAG3, lymphocyte activation gene 3; PD1, programmed cell death protein 1; PDL, PD1 ligand; TGFβ, transforming growth factor-β; TIM3, T cell membrane protein 3. Immunotherapy In Phase III trials In Phase I trials Pardoll. Nat Rev Cancer 2012 CD4 + helper T cells T cells that are characterized by the expression of CD4. They recognize antigenic peptides presented by MHC class II molecules. This type of T cell produces a vast range of cytokines that mediate inflammatory and effector Nature Reviews Cancer the expression of which determines the T Reg cell lineage expression of the CTLA4 ligands (other than for some 34,35, and T Reg cells therefore express CTLA4 constitutively. myeloid and lymphoid tumours) and because the dra- Although the mechanism by which CTLA4 matic lethal autoimmune and hyperimmune pheno- enhances the immunosuppressive function of T Reg type of Ctla4-knockout mice predicted a high degree of cells is not known, T Reg cell-specific CTLA4 knockout immune toxicity associated with blockade of this receptor. or blockade significantly inhibits their ability to regulate However, Allison and colleagues 36 used preclinical both autoimmunity and antitumour immunity 30,31. models to demonstrate that a therapeutic window was Thus, in considering the mechanism of action for indeed achieved when CTLA4 was partially blocked with CTLA4 blockade, both enhancement of effector CD4 + antibodies. The initial studies demonstrated significant T cell activity and inhibition of T Reg cell-dependent antitumour responses without overt immune toxicities immunosuppression are probably important factors. when mice bearing partially immunogenic tumours were treated with CTLA4 antibodies as single agents. Poorly Clinical application of CTLA4-blocking antibodies immunogenic tumours did not respond to anti-ctla4 as 14

15 Conclusion 2015 is likely to see some practice changing studies in mesothelioma Targeting downstream pathways of mutations in mesothelioma may enable personalisation of treatment Immune therapies have shown considerable promise in mesothelioma and are likely to alter treatment paradigms in the near future as single agents or in combination Questions? 15

NEW CLINICAL RESEARCH OPTIONS IN PANCREATIC CANCER IMMUNOTHERAPY. Alan Melcher Professor of Clinical Oncology and Biotherapy Leeds

NEW CLINICAL RESEARCH OPTIONS IN PANCREATIC CANCER IMMUNOTHERAPY. Alan Melcher Professor of Clinical Oncology and Biotherapy Leeds NEW CLINICAL RESEARCH OPTIONS IN PANCREATIC CANCER IMMUNOTHERAPY Alan Melcher Professor of Clinical Oncology and Biotherapy Leeds CANCER IMMUNOTHERAPY - Breakthrough of the Year in Science magazine 2013.

More information

Anticancer Immunotherapy A New Weapon Against Cancer JON STEPHENS, MPHIL SENIOR ANALYST, ONCOLOGY

Anticancer Immunotherapy A New Weapon Against Cancer JON STEPHENS, MPHIL SENIOR ANALYST, ONCOLOGY Anticancer Immunotherapy A New Weapon Against Cancer JON STEPHENS, MPHIL SENIOR ANALYST, ONCOLOGY A robust new approach Since its inception in the mid-0th century, chemotherapy has been the mainstay of

More information

The immune system. Bone marrow. Thymus. Spleen. Bone marrow. NK cell. B-cell. T-cell. Basophil Neutrophil. Eosinophil. Myeloid progenitor

The immune system. Bone marrow. Thymus. Spleen. Bone marrow. NK cell. B-cell. T-cell. Basophil Neutrophil. Eosinophil. Myeloid progenitor The immune system Basophil Neutrophil Bone marrow Eosinophil Myeloid progenitor Dendritic cell Pluripotent Stem cell Lymphoid progenitor Platelets Bone marrow Thymus NK cell T-cell B-cell Spleen Cancer

More information

Predictive Biomarkers for PD1 Pathway Inhibitor Immunotherapy

Predictive Biomarkers for PD1 Pathway Inhibitor Immunotherapy Predictive Biomarkers for PD1 Pathway Inhibitor Immunotherapy Michael B. Atkins, M.D. Deputy Director Georgetown-Lombardi Comprehensive Cancer Center Michael Atkins, MD Consulting Fees (e.g., advisory

More information

BOLT Hem/Onc Thought Leader Panel #38 Cancer Immunotherapy 2014-05

BOLT Hem/Onc Thought Leader Panel #38 Cancer Immunotherapy 2014-05 Syndicated Thought Leader Insight Healthcare & Pharmaceutical Research Cancer Immunotherapy Melanoma, Non- Small Cell Lung Cancer, Renal Cell Carcinoma Thought Leader Panel #38 2014-05 Therapeutic Area:

More information

Melanoma and Immunotherapy

Melanoma and Immunotherapy Melanoma and Immunotherapy Sanjiv S. Agarwala, MD Professor of Medicine Temple University School of Medicine Chief, Oncology & Hematology St. Luke s Cancer Center, Bethlehem, PA The Transformed Landscape

More information

Immuno-Oncology, The New Era of Cancer Treatment. Ted Lee, MD, MPH Disease Area Head, IO, Pac Rim, Bristol Myers Squibb

Immuno-Oncology, The New Era of Cancer Treatment. Ted Lee, MD, MPH Disease Area Head, IO, Pac Rim, Bristol Myers Squibb Immuno-Oncology, The New Era of Cancer Treatment Ted Lee, MD, MPH Disease Area Head, IO, Pac Rim, Bristol Myers Squibb 1 Disclosures Dr. Ted Lee is an employee of Bristol-Myers Squibb Co. New Therapies

More information

Foundational Issues Related to Immunotherapy and Melanoma

Foundational Issues Related to Immunotherapy and Melanoma Transcript Details This is a transcript of a continuing medical education (CME) activity accessible on the ReachMD network. Additional media formats for the activity and full activity details (including

More information

Immunotherapy Concept Turned Reality

Immunotherapy Concept Turned Reality Authored by: Jennifer Dolan Fox, PhD VirtualScopics Inc. jennifer_fox@virtualscopics.com +1 585 249 6231 Immunotherapy Concept Turned Reality Introduction While using the body s own immune system as a

More information

Cancer Immunotherapy: Can Your Immune System Cure Cancer? Steve Emerson, MD, PhD Herbert Irving Comprehensive Cancer Center

Cancer Immunotherapy: Can Your Immune System Cure Cancer? Steve Emerson, MD, PhD Herbert Irving Comprehensive Cancer Center Cancer Immunotherapy: Can Your Immune System Cure Cancer? Steve Emerson, MD, PhD Herbert Irving Comprehensive Cancer Center Bodnar s Law Simple Things are Important Very Simple Things are Very Important

More information

B Cells and Antibodies

B Cells and Antibodies B Cells and Antibodies Andrew Lichtman, MD PhD Brigham and Women's Hospital Harvard Medical School Lecture outline Functions of antibodies B cell activation; the role of helper T cells in antibody production

More information

specific B cells Humoral immunity lymphocytes antibodies B cells bone marrow Cell-mediated immunity: T cells antibodies proteins

specific B cells Humoral immunity lymphocytes antibodies B cells bone marrow Cell-mediated immunity: T cells antibodies proteins Adaptive Immunity Chapter 17: Adaptive (specific) Immunity Bio 139 Dr. Amy Rogers Host defenses that are specific to a particular infectious agent Can be innate or genetic for humans as a group: most microbes

More information

Oncologist-to-Oncologist: How to Treat Your Patients with Immunotherapy

Oncologist-to-Oncologist: How to Treat Your Patients with Immunotherapy Oncologist-to-Oncologist: How to Treat Your Patients with Immunotherapy Michael A. Postow, M.D. Memorial Sloan Kettering Cancer Center Wednesday, June 10, 2015 11:00 a.m. EDT Brought to you by the Cancer

More information

Cancer Immunotherapy: immune checkpoint inhibitors, cancer vaccines, and adoptive T-cell therapies - Overview

Cancer Immunotherapy: immune checkpoint inhibitors, cancer vaccines, and adoptive T-cell therapies - Overview Brochure More information from http://www.researchandmarkets.com/reports/3066973/ Cancer Immunotherapy: immune checkpoint inhibitors, cancer vaccines, and adoptive T-cell therapies - Overview Description:

More information

The Four Pillars of Cancer Therapy

The Four Pillars of Cancer Therapy Improving the Overall Understanding of Immunotherapy in Multiple Myeloma Webinar 2, August 19, 2015 Myeloma Vaccines: A New Use of a Time-Tested Treatment The Four Pillars of Cancer Therapy Surgery Radiation

More information

Chapter 17A: Adaptive Immunity Part I

Chapter 17A: Adaptive Immunity Part I Chapter 17A: Adaptive Immunity Part I 1. Overview of Adaptive Immunity 2. T and B Cell Production 3. Antigens & Antigen Presentation 4. Helper T cells 1. Overview of Adaptive Immunity The Nature of Adaptive

More information

Ovarian Cancer and Modern Immunotherapy: Regulatory Strategies for Drug Development

Ovarian Cancer and Modern Immunotherapy: Regulatory Strategies for Drug Development Ovarian Cancer and Modern Immunotherapy: Regulatory Strategies for Drug Development Sanjeeve Bala, MD, MPH Ovarian Cancer Endpoints Workshop FDA White Oak September 3, 2015 Overview Immune agents from

More information

Mesothelioma 2014. Paul Baas Department of Thoracic Oncology The Netherlands Cancer Institute Amsterdam

Mesothelioma 2014. Paul Baas Department of Thoracic Oncology The Netherlands Cancer Institute Amsterdam Mesothelioma 2014 Paul Baas Department of Thoracic Oncology The Netherlands Cancer Institute Amsterdam Disclosures Grants from Pfizer and Roche Advisor for MSD and Verastem Once upon a time. http://amlbenzene.net/diseases-asbestos.htm

More information

Oncos Therapeutics: ONCOS THERAPEUTICS Personalized Cancer Immunotherapy. March 2015. Antti Vuolanto, COO and co-founder

Oncos Therapeutics: ONCOS THERAPEUTICS Personalized Cancer Immunotherapy. March 2015. Antti Vuolanto, COO and co-founder Oncos Therapeutics: Personalized Cancer Immunotherapy ONCOS THERAPEUTICS Personalized Cancer Immunotherapy March 2015 Antti Vuolanto, COO and co-founder 1 History of Oncos Therapeutics 2002 2007 2009 Research

More information

Targeted Therapy What the Surgeon Needs to Know

Targeted Therapy What the Surgeon Needs to Know Targeted Therapy What the Surgeon Needs to Know AATS Focus in Thoracic Surgery 2014 David R. Jones, M.D. Professor & Chief, Thoracic Surgery Memorial Sloan Kettering Cancer Center I have no disclosures

More information

Immune Checkpoint Blockade in Acute Myeloid Leukemia. Kinsey McCormick Hematology Fellow s Conference January 10, 2014

Immune Checkpoint Blockade in Acute Myeloid Leukemia. Kinsey McCormick Hematology Fellow s Conference January 10, 2014 Immune Checkpoint Blockade in Acute Myeloid Leukemia Kinsey McCormick Hematology Fellow s Conference January 10, 2014 Overview Overview of immune checkpoints Immune checkpoints as mechanism of immune evasion

More information

Corporate Presentation June 2, 2015

Corporate Presentation June 2, 2015 Corporate Presentation June 2, 2015 SAFE HARBOR STATEMENT This presentation contains forward-looking statements. Although the Company believes its expectations are based on reasonable assumptions, these

More information

Enhancing Anti-Tumor Activity of Checkpoint Inhibition

Enhancing Anti-Tumor Activity of Checkpoint Inhibition Enhancing Anti-Tumor Activity of Checkpoint Inhibition Jeffrey Schlom, Ph.D. Laboratory of Tumor Immunology and Biology (LTIB) Center for Cancer Research National Cancer Institute, NIH Laboratory of Tumor

More information

Targeted immunotherapy: unleashing the immune system against cancer

Targeted immunotherapy: unleashing the immune system against cancer Targeted immunotherapy: unleashing the immune system against cancer Suzanne L. Topalian, MD Johns Hopkins University School of Medicine Sidney Kimmel Comprehensive Cancer Center 2013 MMS Annual Education

More information

Activation and effector functions of HMI

Activation and effector functions of HMI Activation and effector functions of HMI Hathairat Thananchai, DPhil Department of Microbiology Faculty of Medicine Chiang Mai University 25 August 2015 ว ตถ ประสงค หล งจากช วโมงบรรยายน แล วน กศ กษาสามารถ

More information

Coordinating Immune Checkpoint Blockade For Cancer Immunotherapy In Combination

Coordinating Immune Checkpoint Blockade For Cancer Immunotherapy In Combination Coordinating Immune Checkpoint Blockade For Cancer Immunotherapy In Combination Jennifer Mataraza, Ph.D. Senior Investigator Immune Oncology, NIBR March 25, 2015 (Image: Steve Gshmeisserner/Science Photo

More information

Cancer and the immune system: can we beat cancer at its own game?

Cancer and the immune system: can we beat cancer at its own game? Cancer and the immune system: can we beat cancer at its own game? Andrew R. Haas, MD, PhD Assistant Professor of Medicine University of Pennsylvania Medical Center Philadelphia, Pa Why can t immune

More information

Dendritic Cells: A Basic Review *last updated May 2003

Dendritic Cells: A Basic Review *last updated May 2003 *last updated May 2003 Prepared by: Eric Wieder, PhD MD Anderson Cancer Center Houston, TX USA What is a dendritic cell? Dendritic cells are antigen-presenting cells (APCs) which play a critical role in

More information

ASCO 12. PD-1 Immunotherapy Makes a Splash at ASCO

ASCO 12. PD-1 Immunotherapy Makes a Splash at ASCO PD-1 Immunotherapy Makes a Splash at ASCO By Gregory R. Wolfe, PhD Epigenetic variation and genetic instability in tumor cells yield a variety of tumor antigens that the immune system can recognize to

More information

Anti-PD1 Agents: Immunotherapy agents in the treatment of metastatic melanoma. Claire Vines, 2016 Pharm.D. Candidate

Anti-PD1 Agents: Immunotherapy agents in the treatment of metastatic melanoma. Claire Vines, 2016 Pharm.D. Candidate + Anti-PD1 Agents: Immunotherapy agents in the treatment of metastatic melanoma Claire Vines, 2016 Pharm.D. Candidate + Disclosure I have no conflicts of interest to disclose. + Objectives Summarize NCCN

More information

Immunotherapy for High-Risk and Metastatic Melanoma

Immunotherapy for High-Risk and Metastatic Melanoma Immunotherapy for High-Risk and Metastatic Melanoma Timothy M. Kuzel, MD Professor of Medicine and Dermatology Feinberg School of Medicine Northwestern University Chicago ICLIO 1 st Annual National Conference

More information

Mesothelioma Applied Research Foundation www.curemeso.org

Mesothelioma Applied Research Foundation www.curemeso.org Mesothelioma Applied Research Foundation www.curemeso.org Board of Directors Michael Becich PhD Gen. Steven Blum Lee Krug MD David Ettinger MD Axel Ranier Richard Mosca Erica Iacono Terry Lynch Hanne Minz

More information

B cell activation and Humoral Immunity

B cell activation and Humoral Immunity B cell activation and Humoral Immunity Humoral immunity is mediated by secreted antibodies and its physiological function is defense against extracellular microbes (including viruses) and microbial exotoxins.

More information

Immuno-Oncology 2015: A New Landscape in Lung Cancer

Immuno-Oncology 2015: A New Landscape in Lung Cancer Immuno-Oncology 2015: A New Landscape in Lung Cancer David R. Spigel, M.D. Lung Cancer Program Director Sarah Cannon Research Institute/Tennessee Oncology, PLLC Nashville, TN Off-Label Use Disclosure(s)

More information

Current Status of Immunotherapy For the Treatment of Metastatic Melanoma

Current Status of Immunotherapy For the Treatment of Metastatic Melanoma Current Status of Immunotherapy For the Treatment of Metastatic Melanoma The 2016 Arizona Clinical Oncology Society Meeting Richard W. Joseph, MD Assistant Professor Mayo Clinic Florida joseph.richard@mayo.edu

More information

Breakthrough Cancer Therapies: Directing the Immune System to Eliminate Tumor Cells. Corporate Presentation May 2015

Breakthrough Cancer Therapies: Directing the Immune System to Eliminate Tumor Cells. Corporate Presentation May 2015 Breakthrough Cancer Therapies: Directing the Immune System to Eliminate Tumor Cells Corporate Presentation May 2015 Forward-looking statements / safe harbor This presentation and the accompanying oral

More information

FAK INHIBITOR DEFACTINIB (VS-6063) TARGETS MESOTHELIOMA CANCER STEM CELLS. Jonathan Pachter, Ph.D.

FAK INHIBITOR DEFACTINIB (VS-6063) TARGETS MESOTHELIOMA CANCER STEM CELLS. Jonathan Pachter, Ph.D. FAK INHIBITOR DEFACTINIB (VS-6063) TARGETS MESOTHELIOMA CANCER STEM CELLS Rationale for maintenance therapy after conventional therapy Jonathan Pachter, Ph.D. Vice President of Research, Verastem, Inc.

More information

HUMORAL IMMUNE RE- SPONSES: ACTIVATION OF B CELLS AND ANTIBODIES JASON CYSTER SECTION 13

HUMORAL IMMUNE RE- SPONSES: ACTIVATION OF B CELLS AND ANTIBODIES JASON CYSTER SECTION 13 SECTION 13 HUMORAL IMMUNE RE- SPONSES: ACTIVATION OF B CELLS AND ANTIBODIES CONTACT INFORMATION Jason Cyster, PhD (Email) READING Basic Immunology: Functions and Disorders of the Immune System. Abbas,

More information

Cancer Treatments Subcommittee of PTAC Meeting held 18 September 2015. (minutes for web publishing)

Cancer Treatments Subcommittee of PTAC Meeting held 18 September 2015. (minutes for web publishing) Cancer Treatments Subcommittee of PTAC Meeting held 18 September 2015 (minutes for web publishing) Cancer Treatments Subcommittee minutes are published in accordance with the Terms of Reference for the

More information

The renaissance of immunotherapy is a revolution for cancer patients. Ira Mellman, Ph.D. Vice President, Cancer Immunology, Genentech

The renaissance of immunotherapy is a revolution for cancer patients. Ira Mellman, Ph.D. Vice President, Cancer Immunology, Genentech The renaissance of immunotherapy is a revolution for cancer patients Ira Mellman, Ph.D. Vice President, Cancer Immunology, Genentech 1 This presentation contains certain forward-looking statements. These

More information

Immunostimulatory monoclonal antibodies for cancer therapy

Immunostimulatory monoclonal antibodies for cancer therapy Immunostimulatory monoclonal antibodies for cancer therapy Ignacio Melero*, Sandra Hervas-Stubbs*, Martin Glennie, Drew M. Pardoll and Lieping Chen Abstract Increasing immune responses with immunostimulatory

More information

The Past, Present & Future of Cancer Immunotherapy:

The Past, Present & Future of Cancer Immunotherapy: Article The Past, Present & Future of Cancer Immunotherapy: An Overview Recently BioWorld called cancer immunotherapy white hot based on unprecedented investments in private companies, partnerships between

More information

Advances in Treatment of Malignant Pleural Mesothelioma: A Reason for Hope

Advances in Treatment of Malignant Pleural Mesothelioma: A Reason for Hope Advances in Treatment of Malignant Pleural Mesothelioma: A Reason for Hope Daniel H. Sterman, M.D. Associate Professor of Medicine and Surgery Co-Director, PENN Mesothelioma and Pleural Program University

More information

The Most Common Autoimmune Disease: Rheumatoid Arthritis. Bonita S. Libman, M.D.

The Most Common Autoimmune Disease: Rheumatoid Arthritis. Bonita S. Libman, M.D. The Most Common Autoimmune Disease: Rheumatoid Arthritis Bonita S. Libman, M.D. Disclosures Two googled comics The Normal Immune System Network of cells and proteins that work together Goal: protect against

More information

Comparing Immunotherapy with High Dose IL-2 and Ipilimumab

Comparing Immunotherapy with High Dose IL-2 and Ipilimumab Comparing Immunotherapy with High Dose IL-2 and Ipilimumab Michael K Wong MD PhD FRCPC mike.wong@med.usc.edu Disclosures Speaker s Bureau, Advisory Boards, Consultant: Prometheus Bristol Myers Squibb Novartis

More information

TEMA 10. REACCIONES INMUNITARIAS MEDIADAS POR CÉLULAS.

TEMA 10. REACCIONES INMUNITARIAS MEDIADAS POR CÉLULAS. TEMA 10. REACCIONES INMUNITARIAS MEDIADAS POR CÉLULAS. The nomenclature of cytokines partly reflects their first-described function and also the order of their discovery. There is no single unified nomenclature,

More information

What You Need to Know About Lung Cancer Immunotherapy

What You Need to Know About Lung Cancer Immunotherapy What You Need to Know About Lung Cancer Immunotherapy Lung.org/immunotherapy What is immunotherapy? Immunotherapy for cancer, sometimes called immune-oncology, is a type of medicine that treats cancer

More information

Understanding series. new. directions. 1-800-298-2436 LungCancerAlliance.org. A guide for the patient

Understanding series. new. directions. 1-800-298-2436 LungCancerAlliance.org. A guide for the patient Understanding series LUNG CANCER: new treatment directions 1-800-298-2436 LungCancerAlliance.org A guide for the patient TABLE OF CONTENTS What s New in lung cancer? Advancements...4 Changes in genes that

More information

The Immune System: A Tutorial

The Immune System: A Tutorial The Immune System: A Tutorial Modeling and Simulation of Biological Systems 21-366B Shlomo Ta asan Images taken from http://rex.nci.nih.gov/behindthenews/uis/uisframe.htm http://copewithcytokines.de/ The

More information

CD22 Antigen Is Broadly Expressed on Lung Cancer Cells and Is a Target for Antibody-Based Therapy

CD22 Antigen Is Broadly Expressed on Lung Cancer Cells and Is a Target for Antibody-Based Therapy CD22 Antigen Is Broadly Expressed on Lung Cancer Cells and Is a Target for Antibody-Based Therapy Joseph M. Tuscano, Jason Kato, David Pearson, Chengyi Xiong, Laura Newell, Yunpeng Ma, David R. Gandara,

More information

Disclosures. Disclosures. Grand Unification: The rationale for combining immunotherapy and molecular targeted therapy 25/02/2014

Disclosures. Disclosures. Grand Unification: The rationale for combining immunotherapy and molecular targeted therapy 25/02/2014 Grand Unification: The rationale for combining immunotherapy and molecular targeted therapy Ryan J. Sullivan, M.D. Massachusetts General Hospital / Harvard University Canadian Melanoma Conference February

More information

Clinical Trials for Patients with

Clinical Trials for Patients with Clinical Trials for Patients with Malignant Pleural Mesothelioma Lee M. Krug, M.D. Memorial Sloan-Kettering Cancer Center New York, New York Challenges in MPM Clinical Trials Mesothelioma is a rare disease,

More information

18.5 Percent Overall Response Rate Observed in Pembrolizumab-Treated Patients with this Aggressive Form of Breast Cancer

18.5 Percent Overall Response Rate Observed in Pembrolizumab-Treated Patients with this Aggressive Form of Breast Cancer News Release Media Contacts: Annick Robinson Investor Contacts: Joseph Romanelli (514) 837-2550 (908) 740-1986 Stephanie Lyttle NATIONAL Public Relations (514) 843-2365 Justin Holko (908) 740-1879 Merck

More information

2) Macrophages function to engulf and present antigen to other immune cells.

2) Macrophages function to engulf and present antigen to other immune cells. Immunology The immune system has specificity and memory. It specifically recognizes different antigens and has memory for these same antigens the next time they are encountered. The Cellular Components

More information

BADO meeting. Immunotherapy. in Metastatic Melanoma

BADO meeting. Immunotherapy. in Metastatic Melanoma BADO meeting Immunotherapy in Metastatic Melanoma UCL Université catholique de Louvain Prof J-Fr. BAURAIN Medical Oncology Department BADO Meeting Inaugural Lecture 07 december 2013 Melanoma Treatment

More information

Immune Therapy for Pancreatic Cancer

Immune Therapy for Pancreatic Cancer Immune Therapy for Pancreatic Cancer December 16, 2014 If you experience technical difficulty during the presentation: Contact WebEx Technical Support directly at: US Toll Free: 1-866-229-3239 Toll Only:

More information

What is the Optimal Front-Line Treatment for mrcc? Michael B. Atkins, MD Deputy Director, Georgetown-Lombardi Comprehensive Cancer Center

What is the Optimal Front-Line Treatment for mrcc? Michael B. Atkins, MD Deputy Director, Georgetown-Lombardi Comprehensive Cancer Center What is the Optimal Front-Line Treatment for mrcc? Michael B. Atkins, MD Deputy Director, Georgetown-Lombardi Comprehensive Cancer Center The Case for Immunotherapy in mrcc 1. Achieves patient s goal 2.

More information

FARMACOLOGIA DEL SISTEMA INMUNE

FARMACOLOGIA DEL SISTEMA INMUNE FARMACOLOGIA DEL SISTEMA INMUNE Inmunosupresión Inmunoestimulación Medicina Molecular. JM,2008 Las dos caras de Janus INMUNOSUPRESIÓN CICLOSPORINA Jean Francois Borel Scanning electron micrograph of

More information

Immuno-Oncology Therapies to Treat Lung Cancer

Immuno-Oncology Therapies to Treat Lung Cancer Immuno-Oncology Therapies to Treat Lung Cancer What you need to know ONCHQ14NP07519 Introduction: Immuno-oncology represents an innovative approach to cancer research that seeks to harness the body s own

More information

CLINICAL POLICY Department: Medical Management Document Name: Opdivo Reference Number: CP.PHAR.121 Effective Date: 07/15

CLINICAL POLICY Department: Medical Management Document Name: Opdivo Reference Number: CP.PHAR.121 Effective Date: 07/15 Page: 1 of 6 IMPORTANT REMINDER This Clinical Policy has been developed by appropriately experienced and licensed health care professionals based on a thorough review and consideration of generally accepted

More information

T Cell Maturation,Activation and Differentiation

T Cell Maturation,Activation and Differentiation T Cell Maturation,Activation and Differentiation Positive Selection- In thymus, permits survival of only those T cells whose TCRs recognize self- MHC molecules (self-mhc restriction) Negative Selection-

More information

1 page Overview. CONCURRENT 1D, 1E, 1F Biology & Pathogenesis Multi-Modality Immunology 1

1 page Overview. CONCURRENT 1D, 1E, 1F Biology & Pathogenesis Multi-Modality Immunology 1 1 page Overview 21 Oct Tuesday 1500 on REGISTRATION 1800 Welcome Reception & Cocktails at the Cape Town International Conference Centre (CTICC) 22 Oct Wednesday 0730 REGISTRATION 0830 OPENING 0900 PLENARY

More information

This presentation may contain forward-looking statements, which reflect Trillium's current expectation regarding future events. These forward-looking

This presentation may contain forward-looking statements, which reflect Trillium's current expectation regarding future events. These forward-looking Q1/2016 This presentation may contain forward-looking statements, which reflect Trillium's current expectation regarding future events. These forward-looking statements involve risks and uncertainties

More information

Corporate Medical Policy

Corporate Medical Policy Corporate Medical Policy File Name: Origination: Last CAP Review: Next CAP Review: Last Review: adoptive_immunotherapy 11/1993 3/2016 3/2017 3/2016 Description of Procedure or Service The spontaneous regression

More information

CIRM Webinar: CAR-T Cell Immunotherapy - Challenges and Opportunities Using Mature or Stem Memory T Cells, March 18th, 2015 Margo R Roberts, Ph.D.

CIRM Webinar: CAR-T Cell Immunotherapy - Challenges and Opportunities Using Mature or Stem Memory T Cells, March 18th, 2015 Margo R Roberts, Ph.D. CIRM Webinar: CAR-T Cell Immunotherapy - Challenges and Opportunities Using Mature or Stem Memory T Cells, March 18th, 2015 Margo R Roberts, Ph.D. Forward Looking Statements / Safe Harbor To the extent

More information

Welcome to the Launch of Biocon s Breakthrough Innovation. For Psoriasis. Treatment

Welcome to the Launch of Biocon s Breakthrough Innovation. For Psoriasis. Treatment Welcome to the Launch of Biocon s Breakthrough Innovation For Psoriasis Treatment PRESS MEET Bangalore, August 10, 2013 Autoimmune Diseases are on the Rise Globally Autoimmune Disease Segment includes

More information

SOPHOMORE DENTAL/OPTOMETRY MICROBIOLOGY SECTION: IMMUNOLOGY

SOPHOMORE DENTAL/OPTOMETRY MICROBIOLOGY SECTION: IMMUNOLOGY SOPHOMORE DENTAL/OPTOMETRY MICROBIOLOGY SECTION: IMMUNOLOGY LYMPHOCYTE ACTIVATION Lecturer: Louis B. Justement, Ph.D. 934-1429 lbjust@uab.edu Objectives: To review the structure of the T and B cell antigen

More information

Maintenance therapy in in Metastatic NSCLC. Dr Amit Joshi Associate Professor Dept. Of Medical Oncology Tata Memorial Centre Mumbai

Maintenance therapy in in Metastatic NSCLC. Dr Amit Joshi Associate Professor Dept. Of Medical Oncology Tata Memorial Centre Mumbai Maintenance therapy in in Metastatic NSCLC Dr Amit Joshi Associate Professor Dept. Of Medical Oncology Tata Memorial Centre Mumbai Definition of Maintenance therapy The U.S. National Cancer Institute s

More information

Combining Immunotherapy and Targeted Therapy in Melanoma

Combining Immunotherapy and Targeted Therapy in Melanoma Combining Immunotherapy and Targeted Therapy in Melanoma 8:45 am - 9:15 am Antoni Ribas, M.D., h.d. rofessor of Medicine rofessor of Surgery rofessor of Molecular and Medical harmacology Director, Tumor

More information

Micro 204 Tumor Immunology.

Micro 204 Tumor Immunology. Micro 204 Tumor Immunology Lewis.Lanier@ucsf.edu Immunological Surveillance Ehrlich, Burnet & Thomas Paul Ehrlich (1909) Concept of cancer immunosurveillance. Predicted that cancer would occur at incredible

More information

Autoimmunity and immunemediated. FOCiS. Lecture outline

Autoimmunity and immunemediated. FOCiS. Lecture outline 1 Autoimmunity and immunemediated inflammatory diseases Abul K. Abbas, MD UCSF FOCiS 2 Lecture outline Pathogenesis of autoimmunity: why selftolerance fails Genetics of autoimmune diseases Therapeutic

More information

LESSON 3: ANTIBODIES/BCR/B-CELL RESPONSES

LESSON 3: ANTIBODIES/BCR/B-CELL RESPONSES Introduction to immunology. LESSON 3: ANTIBODIES/BCR/B-CELL RESPONSES Today we will get to know: The antibodies How antibodies are produced, their classes and their maturation processes Antigen recognition

More information

AN INTRODUCTION TO IMMUNOLOGY. Paul Thomas Unit 1 Department of Immunology St. Jude Children s Research Hospital

AN INTRODUCTION TO IMMUNOLOGY. Paul Thomas Unit 1 Department of Immunology St. Jude Children s Research Hospital AN INTRODUCTION TO IMMUNOLOGY Paul Thomas Unit 1 Department of Immunology St. Jude Children s Research Hospital CATEGORIES OF PATHOGENS Viruses (~0.2 microns) Bacteria (1-2 microns) Parasites (Millimeters)

More information

Presenter Disclosure: Renier J. Brentjens, MD, PhD. Nothing to disclose

Presenter Disclosure: Renier J. Brentjens, MD, PhD. Nothing to disclose Presenter Disclosure: Renier J. Brentjens, MD, PhD Nothing to disclose Adoptive Therapy of Cancer with T cells Genetically Targeted to Tumor Associated Antigens through the Introduction of Chimeric Antigen

More information

Update on Clinical Trials and Foundation Funded Grants

Update on Clinical Trials and Foundation Funded Grants Update on Clinical Trials and Foundation Funded Grants Mary Hesdorffer, MS, APRN-BC Medical Liaison Meso Foundation www.curemeso.org Delivering the Diagnosis Delivering the Diagnosis Day 1 Taking control

More information

This report focuses on the rising potential for the newest and most promising of cancer treatments:

This report focuses on the rising potential for the newest and most promising of cancer treatments: 1 Cancer Immunotherapy: Immune Checkpoint Inhibitors, Cancer Vaccines, and Adoptive T-cell Therapies Allan B. Haberman. Ph.D. This report focuses on the rising potential for the newest and most promising

More information

PARP Inhibitors in Lung Cancer. Primo N. Lara, Jr., MD Professor of Medicine UC Davis Comprehensive Cancer Center

PARP Inhibitors in Lung Cancer. Primo N. Lara, Jr., MD Professor of Medicine UC Davis Comprehensive Cancer Center PARP Inhibitors in Lung Cancer Primo N. Lara, Jr., MD Professor of Medicine UC Davis Comprehensive Cancer Center Poly (ADP-ribose) Polymerase (PARP): Mechanism of Action PARPs: family of enzymes that repair

More information

Principal Investigator: Valerie W. Rusch, MD, FACS, Chief, Thoracic Surgery Memorial Sloan-Kettering Cancer Center

Principal Investigator: Valerie W. Rusch, MD, FACS, Chief, Thoracic Surgery Memorial Sloan-Kettering Cancer Center Protocol 1101-1088 Phase I study of intra-pleural administration of GL-ONC1 in patients with malignant pleural effusion: primary, metastases and mesothelioma Principal Investigator: Valerie W. Rusch, MD,

More information

The role of IBV proteins in protection: cellular immune responses. COST meeting WG2 + WG3 Budapest, Hungary, 2015

The role of IBV proteins in protection: cellular immune responses. COST meeting WG2 + WG3 Budapest, Hungary, 2015 The role of IBV proteins in protection: cellular immune responses COST meeting WG2 + WG3 Budapest, Hungary, 2015 1 Presentation include: Laboratory results Literature summary Role of T cells in response

More information

Cytotoxic T Lymphocytes (CTLs) and NK Cells. Effector T cells. After activation, naïve T cells differentiate into effector and memory T cells

Cytotoxic T Lymphocytes (CTLs) and NK Cells. Effector T cells. After activation, naïve T cells differentiate into effector and memory T cells After activation, naïve T cells differentiate into effector and memory T cells Cytotoxic T Lymphocytes (CTLs) and NK Cells After activation, T cells remain in lymph nodes for 5-6 days Effector T cells

More information

Targeting Specific Cell Signaling Pathways for the Treatment of Malignant Peritoneal Mesothelioma

Targeting Specific Cell Signaling Pathways for the Treatment of Malignant Peritoneal Mesothelioma The Use of Kinase Inhibitors: Translational Lab Results Targeting Specific Cell Signaling Pathways for the Treatment of Malignant Peritoneal Mesothelioma Sheelu Varghese, Ph.D. H. Richard Alexander, M.D.

More information

PROSPETTIVE FUTURE NEL TRATTAMENTO. Cinzia Ortega Dipartimento di Oncologia Medica Fondazione del Piemonte per l Oncologia I.R.C.C.S.

PROSPETTIVE FUTURE NEL TRATTAMENTO. Cinzia Ortega Dipartimento di Oncologia Medica Fondazione del Piemonte per l Oncologia I.R.C.C.S. PROSPETTIVE FUTURE NEL TRATTAMENTO MEDICO DEL mrcc Cinzia Ortega Dipartimento di Oncologia Medica Fondazione del Piemonte per l Oncologia I.R.C.C.S. Candiolo Future strategies in mrcc Improve therapeutic

More information

IMMUNOTHERAPY OF CANCER: TOWARDS A NEW ERA

IMMUNOTHERAPY OF CANCER: TOWARDS A NEW ERA IMMUNOTHERAPY OF CANCER: TOWARDS A NEW ERA Disclosure: No potential conflict of interest. Received: 22.04.14 Accepted: 22.07.14 Citation: EMJ Oncol. 2014;2:76-82. *John B.A.G. Haanen The Netherlands Cancer

More information

Lung Cancer: More than meets the eye

Lung Cancer: More than meets the eye Lung Cancer Education Program November 23, 2013 Lung Cancer: More than meets the eye Shantanu Banerji MD, FRCPC Presenter Disclosure Faculty: Shantanu Banerji Relationships with commercial interests: Grants/Research

More information

International Symposium on Malignant Mesothelioma 2011 -- curemeso.org

International Symposium on Malignant Mesothelioma 2011 -- curemeso.org Measles virotherapy for malignant mesothelioma Manish R. Patel, D.O. Assistant Professor of Medicine University of Minnesota June 25, 2011 Medical Treatment of Mesothelioma Majority of patients are not

More information

Recognition of T cell epitopes (Abbas Chapter 6)

Recognition of T cell epitopes (Abbas Chapter 6) Recognition of T cell epitopes (Abbas Chapter 6) Functions of different APCs (Abbas Chapter 6)!!! Directon Routes of antigen entry (Abbas Chapter 6) Flow of Information Barrier APCs LNs Sequence of Events

More information

Immune checkpoint inhibitors in clinical trials

Immune checkpoint inhibitors in clinical trials Chinese Journal of Cancer Review Immune checkpoint inhibitors in clinical trials Elad Sharon 1, Howard Streicher 1, Priscila Goncalves 2 and Helen X. Chen 1 Abstract Immunology-based therapy is rapidly

More information

Trials in Elderly Melanoma Patients (with a focus on immunotherapy)

Trials in Elderly Melanoma Patients (with a focus on immunotherapy) Trials in Elderly Melanoma Patients (with a focus on immunotherapy) Where we were Immunotherapy Trials: past and present Relevance for real world practice Where we are SIOG October 2012 James Larkin FRCP

More information

Medigene Corporate Presentation

Medigene Corporate Presentation Medigene Corporate Presentation This presentation contains forward-looking statements - that is, statements related to future, not past, events. These statements may be identified either orally or in writing

More information

Microbiology AN INTRODUCTION EIGHTH EDITION

Microbiology AN INTRODUCTION EIGHTH EDITION TORTORA FUNKE CASE Microbiology AN INTRODUCTION EIGHTH EDITION Differentiate between innate and acquired immunity. Chapter 17 Specific Defenses of the Host: The Immune Response B.E Pruitt & Jane J. Stein

More information

Name (print) Name (signature) Period. (Total 30 points)

Name (print) Name (signature) Period. (Total 30 points) AP Biology Worksheet Chapter 43 The Immune System Lambdin April 4, 2011 Due Date: Thurs. April 7, 2011 You may use the following: Text Notes Power point Internet One other person in class "On my honor,

More information

Pharmacogenomic markers in EGFR-targeted therapy of lung cancer

Pharmacogenomic markers in EGFR-targeted therapy of lung cancer Pharmacogenomic markers in EGFR-targeted therapy of lung cancer Rafal Dziadziuszko, MD, PhD University of Colorado Cancer Center, Aurora, CO, USA Medical University of Gdansk, Poland EMEA Workshop on Biomarkers,

More information

Your Immune System & Lung Cancer Treatment

Your Immune System & Lung Cancer Treatment Your Immune System & Lung Cancer Treatment Immunotherapy and Lung Cancer Immunotherapy is quickly developing as an important approach to treating many forms of cancer, including lung cancer. Immunotherapy

More information

Pharmacogenomic Approaches. Luis Paz-Ares Hospital Universitario Virgen del Rocio Seville, Spain

Pharmacogenomic Approaches. Luis Paz-Ares Hospital Universitario Virgen del Rocio Seville, Spain Pharmacogenomic Approaches Luis Paz-Ares Hospital Universitario Virgen del Rocio Seville, Spain Pharmacogenetics & Pharmacogenomics Medicine tailored to the individual Genetic information, including the

More information

Pulling the Plug on Cancer Cell Communication. Stephen M. Ansell, MD, PhD Mayo Clinic

Pulling the Plug on Cancer Cell Communication. Stephen M. Ansell, MD, PhD Mayo Clinic Pulling the Plug on Cancer Cell Communication Stephen M. Ansell, MD, PhD Mayo Clinic Why do Waldenstrom s cells need to communicate? Waldenstrom s cells need activating signals to stay alive. WM cells

More information

MAINTENANCE CHEMOTHERAPY

MAINTENANCE CHEMOTHERAPY 1 MAINTENANCE CHEMOTHERAPY FOR ADVANCED NSCLC Dr.M.V.Nagarjuna OBJECTIVES OF THIS SEMINAR 1. Definitions 2. Switch maintenance 3. Continuation Maintenance 4. Immunotherapy as maintenance 5. Conclusions

More information

Moving forward, where are we with Clinical Trials?

Moving forward, where are we with Clinical Trials? Moving forward, where are we with Clinical Trials? Dennis A. Wigle Division of Thoracic Surgery Mayo Clinic AATS/STS General Thoracic Surgery Symposium Sunday, April 27 th 2014 2012 MFMER slide-1 Where

More information

ΔΕΝΤΡΙΤΙΚΑ ΚΥΤΤΑΡΑ ΚΑΙ ΕΜΒΟΛΙΑ ΓΙΑ ΤΟΝ ΚΑΡΚΙΝΟ DENDRITIC CELLS AND CANCER VACCINES

ΔΕΝΤΡΙΤΙΚΑ ΚΥΤΤΑΡΑ ΚΑΙ ΕΜΒΟΛΙΑ ΓΙΑ ΤΟΝ ΚΑΡΚΙΝΟ DENDRITIC CELLS AND CANCER VACCINES ΔΕΝΤΡΙΤΙΚΑ ΚΥΤΤΑΡΑ ΚΑΙ ΕΜΒΟΛΙΑ ΓΙΑ ΤΟΝ ΚΑΡΚΙΝΟ DENDRITIC CELLS AND CANCER VACCINES David Hunt. Cell Systems Initiative, U. of Washington. Βαίος Καρανίκας EU Marie Curie Fellow Μοναδα Ανοσολογίας Καρκίνου

More information

Non-Small Cell Lung Cancer

Non-Small Cell Lung Cancer Non-Small Cell Lung Cancer in East tasia Chia-Chi (Josh) Lin, MD, PhD 林 家 齊 Director of Phase I Center, e Department of Oncology, National Taiwan University Hospital Clinical Associate Professor, Department

More information

Natalia Taborda Vanegas. Doc. Sci. Student Immunovirology Group Universidad de Antioquia

Natalia Taborda Vanegas. Doc. Sci. Student Immunovirology Group Universidad de Antioquia Pathogenesis of Dengue Natalia Taborda Vanegas Doc. Sci. Student Immunovirology Group Universidad de Antioquia Infection process Epidermis keratinocytes Dermis Archives of Medical Research 36 (2005) 425

More information