Curriculum vitae Lila M. Gierasch

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1 Curriculum vitae Lila M. Gierasch Distinguished Professor, Department of Biochemistry & Molecular Biology and Department of Chemistry University of Massachusetts Amherst, MA (413) ; Fax (413) ; EDUCATION Mount Holyoke College, So. Hadley, MA Harvard University, Cambridge, MA A.B Chemistry Ph.D Biophysics (E.R. Blout, advisor) PROFESSIONAL EXPERIENCE Assistant Professor of Chemistry, Amherst College Visiting Scientist, Université Louis Pasteur de Strasbourg (with J.M. Lehn) Assistant Professor of Chemistry, University of Delaware Associate Professor of Chemistry, University of Delaware Visiting Scientist, Smith Kline & French Professor of Chemistry, University of Delaware Professor of Pharmacology and Robert A. Welch Professor of Biochemistry, The University of Texas Southwestern Medical Center at Dallas Director, Molecular Biophysics Graduate Program, UT Southwestern Head, Dept. of Chemistry, Univ. of Massachusetts Amherst Head, Dept. of Biochem. & Mol. Biology, Univ. of Massachusetts, Amherst Professor of Chemistry, Univ. of Massachusetts Amherst Professor of Biochemistry & Molecular Biology, Univ. of Massachusetts Amherst Distinguished Professor, University of Massachusetts, Amherst HONORS AND AWARDS 1970 A. B. conferred summa cum laude and with great distinction NSF Predoctoral Fellowship French Ministry of Foreign Affairs Fellowship A.P. Sloan Fellowship 1984 Vincent du Vigneaud Award for Young Investigators in Peptide Research 1985 Mary Lyon Award, Mount Holyoke College 1986 Guggenheim Fellowship 1987 Distinguished Faculty Lecturer, College of Arts & Science, Univ. of Delaware 1989 Fellow, American Association for the Advancement of Science 1999 Distinguished Faculty Lecturer/Chancellor s Medal, Univ. of Massachusetts 2002 D. Sc. Honoris Causa, Mount Holyoke College 2002 Samuel F. Conti Faculty Fellowship, University of Massachusetts, Amherst 2002 Outstanding Service Award, College of Nat. Sci. & Math., UMass, Amherst 2006 Named Distinguished Professor, University of Massachusetts, Amherst 2006 Francis P. Garvan-John M. Olin Medal of the American Chemical Society 2006 Award for Outstanding Accomplishments in Research & Creative Activity, UMass 2006 NIH Director s Pioneer Award 2008 Fellow, Massachusetts Academy of Science 2008 Goodman Lecturer, Univ. of California, San Diego 2009 Welch Lecturer, Texas 2010 Dorothy Crowfoot Hodgkin Award, The Protein Society 2013 Fellow, Biophysical Society 2014 Mildred Cohn Award, ASBMB 1

2 Curriculum vitae, Lila M. Gierasch, continued Page 2 SERVICE TO PROFESSION Consultant, NICHD Contracts Program on Peptides as Gonadotropin Inhibitors Member, BBCB Study Section, NIH Consultant, Merck Sharp & Dohme Research Laboratories Member, Scientific Advisory Board, Biosym Technologies, Inc Founder and Director, Molecular Biophysics Graduate Program, UT Southwestern Member, Scientific Advisory Board, Damon Runyon/Walter Winchell Foundation Member, Selection and Scheduling Committee, Gordon Res. Conferences 1996 Member, Visiting Committee, Dept. of Chemistry, Duke University 1997 Member, Chemical Sciences Roundtable, National Research Council Member, National Advisory General Medical Sciences Council, NIH Member, Advisory Committee, Directorate for Math and Physical Sciences, NSF Member, American Peptide Symposium Planning Committee Member, Council of the American Peptide Society Member, U.S. National Committee for IUPAC Member, U.S. National Committee for IUPAB (Chair, 1997) Chair, Biophysical Society Publications Committee President, Biophysical Society Member, FASEB Board Member, Finance Committee, Biophysical Society Executive Committee, Div. of Biol. Chem., Amer. Chem. Soc Member, Nominating Committee, ASBMB 1988 Chair, "Proteins" Gordon Research Conference 1988 Co-Organizer, AAAS Symposium Protein Folding 1991 Program Chair, Biophysical Society Annual Meeting 1993,1995 Vice-Chair, Chair "Membrane-Molecular Biology" Gordon Research Conference 2002,2004 Vice-Chair, Chair Protein Folding Cell FASEB Summer Conference 2002 Outside Review Panel, Dept. of Biochemistry, Purdue University Member, Council, ASBMB Member, Finance Committee, Biophysical Society Member, Discussions Committee, Biophysical Society 2004 Member, Physical Biochemistry Study Section, NIH Member, MSFB Study Section, NIH 2005 Co-Organizer, Johns Hopkins Folding Meeting Executive Committee, Biological Division of the American Chemical Society Member, External Advisory Committee, University of Kansas COBRE Grant Member, Executive Council, The Protein Society Member, Protein Structure Initiative Advisory Committee to NIGMS Council Member, Advisory Committee, FASEB Summer Conferences Member, Scientific Advisory Board, Mass. Life Sciences Initiative 2009 External Review Committee, Dept. of Chemistry, Univ. of Virginia Consultant, Vertex Pharmaceuticals 2009 Co-Organizer, Keystone Meeting on Protein Dynamics and Allostery Elected member, American Peptide Society Nominating Committee 2011 External review committee, Boston University Med. School Graduate Program in Molecular Biophysics 2011 External review committee, UCSF Graduate Program in Biophysics 2012 Co-organizer, 6 th Peptide Engineering Meeting, Emory Univ., October Member, PSI:Biology Evaluation Team, NIGMS, NIH Chair, Biopolymers In Vivo Subgroup, Biophysical Society Elected member, ASBMB Nominating Committee National Institutes of General Medical Sciences Future of Structural Biology Committee Elected member, Biophysical Society Nominating Committee 2

3 Curriculum vitae, Lila M. Gierasch, continued Page Dissertation Opponent, Linkoping University, Sweden 2014 External review committee, Wesleyan University Biophysics Program 2014 External review committee, University of Texas, Austin, Molecular Biosciences Department Member, NIH Office of the Director Council of Councils SOCIETY MEMBERSHIPS AAAS, ACS, ASBMB, Biophysical Soc., Amer. Soc. Cell Biol., Amer. Peptide Soc., The Protein Society EDITORIAL ADVISORY BOARDS Journal of Molecular Recognition International Journal of Peptide and Protein Research Biochemistry Folding and Design Peptide Research Journal of Peptide Research Journal of Biological Chemistry Biopolymers Proteins: Structure, Function and Genetics Chemistry & Biology Structure with Folding & Design Editor-in-Chief, Peptide Science Associate Editor, Peptide Science Protein Science Chemical Biology and Drug Design Chemistry Central Journal Accounts of Chemical Research INVITED LECTURES (2003 TO PRESENT) Invited Lecture, Johns Hopkins Folding Meeting, Coolfont, W. Va., March Invited Lecture, Gibbs Conference, Carbondale, IN, September Plenary Lecture, South American Biophysical Society Meeting, Bariloche, Argentina, November Plenary Lecture, New Zealand Molecular Biology Meeting, Queensland, New Zealand, November Theo Hofman Lecture, University of Toronto, May Invited Lecture, Proteins Gordon Research Conference, June Invited Lecture, The Protein Society Meeting, Boston, July Invited Lecture, DIMACS Symposium on Protein Misfolding and Aggregation Diseases, Rutgers, April Invited Lecture, Biopolymers Gordon Research Conference, June Invited Lecture, Bacterial Cell Surfaces Gordon Research Conference, July Invited Lecture, FASEB Meeting, Protein Folding in the Cell, July Invited Lecture, European Peptide Symposium, Gdansk, Poland, September Invited Lecture, American Chemical Society Meeting, September Invited Lecture, Northeast Structure Symposium, Storrs, CT September Invited Lecture, Japanese Peptide Symposium, Yokohama, Japan, November Invited Lecture, American Peptide Symposium, Montreal, Canada, June Plenary Lecture, Harden Conference on Protein Folding in the Cell, Ambleside, England, August Invited Lecture, Biomolecular Interactions & Methods Gordon Conference, Ventura, CA. January Keynote Speaker, Midwest Stress Response and Molecular Chaperone Meeting. January Goodman Lecture, Univ. of California San Diego. February Keynote Dinner Speaker, Rosensteil Award ceremony, Brandeis Univ. March Plenary Shell Science Speaker, National Science Teachers Assoc. Conference. March

4 Curriculum vitae, Lila M. Gierasch, continued Page 4 Invited Speaker, ASBMB Annual Meeting. San Diego, CA. April Wriston Memorial Lectureship, University of Delaware. April Invited Lecture. Proteins Gordon Conference. June Invited Lecture. FASEB Meeting, Protein Folding in the Cell. July Plenary Speaker, Allen Symposium, Clark Univ. October Plenary Speaker, Protein Misfolding Diseases Symposium at the Amer. Soc. of Nephrology Conference. November Plenary Speaker, Bunsen 2009 Amyloid Conference, Halle, Germany. February Welch Lectureship (lectures at Texas A & M, Univ. of Dallas, and Texas Tech). April Plenary Lecture, Keystone Symposium on Protein Dynamics, Allostery & Function. June Invited Lecture, FASEB Meeting on Nuclear Hormone Receptors. August Plenary Speaker, Barcelona BioMed Conference on Peptide Engineering, Spain October Plenary Speaker, Cohen Foundation Symposium on Protein Folding, Univ. of Maryland, November Keynote Speaker, Peptides Gordon Conference, Ventura, California, February Keynote Speaker, Dept. of Molecular, Microbial and Structural Biology Retreat, U. Conn. Health Center, May Plenary Speaker, WorldWide Magnetic Resonance Conference, Florence, Italy, July Plenary Speaker, Symposium in Honor of Johan Deisenhofer, Dallas, TX, July Invited Speaker, FASEB Conference Protein Folding in the Cell. July Award Lecture, Protein Society Annual Meeting, San Diego, CA, August Plenary Speaker, Nobel Symposium on Protein Biophysics in the Cell, Stockholm, Sweden. August Merck Lecturer, SUNY New Paltz. September Plenary Lecture, Upstate NY NMR Conference. November Plenary Lecture, 10 th German Peptide Symposium. March Plenary Lecture, City College of NY Frontiers of NMR Spectroscopy Symposium. March Plenary Lecture, Barcelona BioMed Conference on Macromolecular Dynamics. Spain, October Plenary Lecture, Cold Spring Harbor Asia Conference on Protein Homeostasis in Health & Disease, Suzhou, China, September Invited Lecture, Protein Folding and Dynamic Gordon Conference, Ventura, California, January Invited Lecture, Lorne Conference on Protein Structure and Function, Australia, February Invited Lecture, Bijvoet Tutorial Symposium, Utrecht, Netherlands, April Invited Lecture, Israel Science Foundation Workshop on Protein Folding and Misfolding: Moving Beyond Simple Model Systems, Israel, May Keynote Lecture, Biopolymers Gordon Conference, June Invited Lecture, FASEB Meeting on Protein Folding in the Cell, August Srere Lecturer, Dept. of Biochemistry and Dept. of Biophysics, UT Southwestern, November Keynote Lecture, IDP Subgroup, Biophysical Society, March New & Notable Lecture, Biophysical Society, March Invited Lecture, EMBO Conference The Biology of Molecular Chaperones, Sardinia, May Plenary Lecture, Swedish Structural Biology Network Annual Conference, June Lamport Lecturer, University of Washington, October University Lecturer, UT Southwestern, January University Lecturer, UMass Medical School, April University Lecturer, University of Chicago, April Invited Lecture, Linkoping University, Sweden, May RESEARCH OVERVIEW 4

5 Curriculum vitae, Lila M. Gierasch, continued Page 5 Our work has the overarching goal of understanding the relationship between amino acid sequence and the preferred conformations of peptides and proteins. Our early work helped establish the now-common approach of using peptide fragments to examine functionally important interactions of proteins. Initially, I designed peptide models of reverse turns. This work has shed light on turn propensities in proteins and offered a basis for design of analogues of bioactive peptides. With collaborators, we developed potent, conformationally-constrained antagonists of gonadotrophin-releasing hormone. We elucidated conformational propensities and physical properties of signal sequences, which helped to explain how diverse sequences target polypeptide chains to the secretory pathway. We were among the first to describe how molecular chaperones recognize unfoldedness in their protein substrates: We showed that the chaperonin GroEL exploits hydrophobic surfaces to recognize substrates, while Hsp70s bind polypeptides as extended chains. Our laboratory discovered the GroEL-interactive mobile loop on GroES. More recent work has provided new mechanistic insights into the allosteric cycle of Hsp70s, central molecular machines in chaperone networks in all organisms. We have investigated the folding mechanism of β-rich proteins. Recently, we are exploring protein folding landscapes in the cell. Genetic incorporation of a specific binding site for a cell-permeable fluorescent dye has provided a measure of protein stability in vivo and allowed off-pathway aggregation events to be observed. We are combining our interrogation of protein folding networks in the cell with modeling of all reactions involving protein folding and quality control in E. coli. Taken together, our approach enables fundamental study of conformational defects that are implicated in human misfolding diseases such as Alzheimer s, Huntington s, and others. 5