2009 annual report. 10th Anniversary Edition

2009 annual report 10th Anniversary Edition

organisation chart key achievements Board Mr Bill Manning Chairman Director Winthrop Professor Philip Thompson Executive Officer Ms Tineke Van der Eecken Celebration of our 10th Anniversary. Breathe Easy lung awareness week. Lung and Biological Sciences Symposium. Biological Sciences CLINICAL Sciences CORPORATE SERVICES Establishment of new professorial post. Expanded organisational structure. Formation of community support group, LIFE. Tissue Repair Associate Professor Steven Mutsaers Clinical Trials Ms Michelle Davies Respirology Dr Lieve Bultynck Receipt of major grants. Continued support for careers of scientists and students. Inflammation / Immunology / Cancer Professor Kanti Bhoola Pulmonary vascular and Advanced lung disease Associate Professor Eli Gabbay Administration & Finance Ms Tineke Van der Eecken Molecular Genetics Winthrop Professor Philip Thompson Physiotherapy Associate Professor Sue Jenkins Public Relations Ms Sharon Squires-Hansen MAKING A DIFFERENCE Pleural Disease Winthrop Professor Gary Lee Infectious Diseases Professor Grant Waterer Community Support LIFE Mrs Edna Brown Ms Jenni Ibrahim Cardiothoracic Surgery Research Mr Mark Newman CF/Bronchiectasis Research Dr Siobhain Mulrennan 2 2009 Annual Report Lung Institute of Western Australia Inc.

contents 4 About LIWA 6 8 Chairman s Report 9 13 Director s Report 14 17 Board Members 18 Scientific Subcommittee Report 19 20 Education Programs and Initiatives 20 21 10th Anniversary Celebrations 22 25 LIWA in the Community Unit Report 26 Biological Sciences 26 29 Tissue Repair 29 31 Inflammation / Immunology / Cancer 31 33 Molecular Genetics 33 35 Pleural Disease Unit 36 Clinical Sciences 36 Clinical Trials Unit 37 39 Pulmonary Vascular and Advanced Lung Disease 39 41 Physiotherapy 41 43 Infectious Diseases 43 44 Cardiothoracic Surgery 44 Cystic Fibrosis / Bronchiectasis 45 Corporate Services 45 Respirology 46 Community Support Group, LIFE 47 Administration / Finance 48 Public Relations 49 Active LIWA 49 50 Partnerships and Alliances 50 Donations and Sponsorships 51 56 Publications Report 57 Grants Report 58 67 Financial Report www.liwa.uwa.edu.au 3

ABOUT LIWA our aims The aims of LIWA are to: Support high quality research into the treatment and management of lung diseases including asthma, chronic bronchitis, emphysema, bronchiectasis, cystic fibrosis, pulmonary vascular diseases, lung cancer, pneumonia and tuberculosis. Support research into associated conditions. Improve the well-being of patients. Support the careers of young scientists. Provide a strong educational and scientific resource for the community at large, and Be an advocacy group for better lung health. our activities Clinical sciences respiratory research, including the Clinical Trials Unit. Biological sciences respiratory research. Education initiatives. Awards and scholarships. Membership (Medical / Scientific; Student; Community; Corporate). Community awareness, advocacy and support activities. Patient support activities. Collaborations with leading clinical and research institutes around the world, and Editorial office of Respirology. about LIWA The Lung Institute of Western Australia (LIWA) is a charitable organisation dedicated to the investigation and treatment of lung disease. As one of only two institutes in Australia with this focus, LIWA prides itself on world-class laboratory science, clinical research and clinical practice with the purpose of making a difference to those with lung disease. Our philosophy is that everyone who comes into contact with the Institute should be better informed and healthier for the experience. Objectives The objectives of LIWA are to: Establish and maintain a centre of excellence for research into all aspects of lung disease that will: conduct laboratory, clinical and epidemiological research into the cause, diagnosis, prevention and treatment of lung diseases. support doctors, scientists, students and other individuals to pursue research careers in lung disease and related disorders. foster international and national networks for research into lung disease. 4 2009 Annual Report Lung Institute of Western Australia Inc.

Promote prevention and best practice in lung diseases by providing community and professional education. Be a source of expert knowledge in relation to lung diseases for health professionals, government, community groups and individuals. Provide leadership in the management and prevention of lung and related disorders. Be a source of clinical advice to patients with lung disease. Be an advocate for patients with respect to lung diseases. Reduce the prevalence of cigarette smoking in the community, and Raise funds to support research and education in lung diseases and related disorders. Background and inspiration to LIWA Lung disease is a common, disabling issue which requires ongoing commitment to the investigation of its causes, treatment and cure. Diseases such as asthma, COPD (chronic obstructive pulmonary disease such as emphysema and chronic bronchitis), pneumonia, lung cancer, pulmonary hypertension, cystic fibrosis and bronchiectasis cause significant disability to individuals as well as placing a large burden on the health system. With one in four families affected by lung disease, research into this group of diseases is a priority for government, health organisations and research bodies around the globe. LIWA s approach to respiratory disease is to integrate scientific research and clinical practice. As a result, many diseases are being addressed and investigated utilising the very best of laboratory and clinical sciences and clinical trials. LIWA s history LIWA was founded as the Asthma and Allergy Research Institute (AARI) in February 1998 by Professor Philip Thompson. Professor Thompson is one of Australia s leading respiratory clinicians who is well recognised for his achievements in research and clinical respiratory medicine. In 2006 the Institute changed its name to the Lung Institute of Western Australia to reflect the broadening scope of its activities. LIWA is administratively based at Sir Charles Gairdner Hospital in Nedlands (SCGH), Western Australia and has operations at Royal Perth Hospital as well as strong affiliations with the University of Western Australia (UWA) and Curtin University. The Institute is committed to strengthening partnerships and affiliations with other academic and respiratory organisations for the benefit of improving the respiratory health of the community. ABOUT LIWA www.liwa.uwa.edu.au 5

ABOUT LIWA CHAIRMAN S REPORT chairman s report Bill Manning Chairman I am pleased to present the report of the Board of the Lung Institute of Western Australia for the Institute s tenth year of operation, being 1 January to 31 December 2009. The Board met on nine occasions during these 12 months. The Board welcomed new members Bill Coleman and Jesper Sentow. Each brings a wealth of experience to add to the Board s expertise. Rachael Offer succeeded Feliciano Sanchez as Cystic Fibrosis WA Representative, and Gary Lee stood in as a UWA representative during Grant Waterer s sabbatical leave. I would like to extend my gratitude to Feliciano Sanchez for his significant contribution as a Board member and for his continued support to LIWA as President of CFWA. I thank the Board members as a whole for taking the time, away from other work as well as family commitments, to assist the Institute in achieving its objectives. 10th Anniversary Celebrations In 2009 the Board endorsed proposals to celebrate the 10th Anniversary of the Institute. This kicked off with a world-class Lung and Biological Sciences Symposium, with presenters from our own ranks among scientists from Berlin, Hong Kong, Beijing and other reputable Australian research institutes. The inaugural Breathe Easy Week was another great initiative and served to raise awareness of lung health in the community. The Board was impressed with the quality and results of the many events held promoting lung health in the wider community and was grateful for the efforts of LIWA staff and supporters. Strategic Directions The Board has identified the following priority areas: Finding a single geographical location to house LIWA; Recruiting senior staff with a superior track record to join LIWA; Embracing and enhancing the role of members; and Developing sustainable resources. Each of these priorities continue to guide initiatives by Institute staff. With regards to a single location, LIWA has been offered accommodation in the new WAIMR research facility on the SCGH grounds. Building is due to start later this year. Professor Gary Lee joined LIWA in 2009 as a world leader in pleural disease research and the Institute is looking at ways to attract more senior academic staff in respiratory health to Western Australia. Board members had the opportunity to take part in an Open Space type meeting which brought together all 6 2009 Annual Report Lung Institute of Western Australia Inc.

LIWA staff and interested Board members to think about how to take LIWA to the next decade of excellence. This generated useful inputs into our strategic planning, which I see as an ongoing process. Policy Development The Board adopted a new Conflict of Interest policy. Policies on more operational matters were referred to the Executive Officer and Management Committee to develop. It is worth noting that input from individual Board members was provided for the development of new standard contracts for clinical trials, for advice on insurance issues, and for the development of new staff contracts. Affiliations Affiliations with universities and other leading organisations in Western Australia have enhanced the Institute s capacity in many different ways. University of Western Australia Our affiliation with UWA continues to be a close and supportive relationship. In 2009, UWA publicly demonstrated its support with the Vice Chancellor, Professor Alan Robson, officially launching LIWA s Lung and Biological Sciences Symposium. The UWA renewed the UWA Centre for Asthma and Allergy Respiratory Research (CAARR). This Centre is managed by LIWA staff with the successful Photo: Free lung testing during Breathe Easy Week representation of senior UWA staff on the Board including Emeritus Professor Lou Landau, Professor Grant Waterer and Winthrop Professor Gary Lee, which is of great benefit to the Institute. I am also pleased to say that this collaboration works on many levels and in day-to-day activities, including involvement in research projects and LIWA sponsorship of scholarships and awards. Cystic Fibrosis Western Australia (CFWA) The affiliation with CFWA continued to strengthen in 2009, with Board representation being provided by Feliciano Sanchez, followed by Rachael Offer. The CFWA Board supported the inaugural Breathe Easy Week lung awareness week initiated by LIWA. In addition, the respective Boards met to discuss the potential establishment of a new professorial position for cystic fibrosis and infectious respiratory disease in Perth. Westcare Westcare and LIWA provide mutual support on an organisational level through reciprocal board membership. Sue Morey represents Westcare on the Board of LIWA. In 2009, Westcare reiterated its desire to support tuberculosis and infectious lung disease research in Western Australia and the two organisations discussed how LIWA could play a future role in managing a dedicated fund towards such research. ABOUT LIWA CHAIRMAN S REPORT www.liwa.uwa.edu.au 7

Australian Society of Clinical Immunology and Allergy (ASCIA) John Bandouvakis continued to informally represent ASCIA on the Board. Western Australian Institute of Medical Research LIWA s affiliation with WAIMR remained robust in 2009, with the prospect of LIWA being housed in the WAIMR managed research facility soon to be built at the QEII Medical Centre campus. Curtin University Our affiliation with Curtin University enables ongoing research, in particular through our Physiotherapy Unit. The agreement with Curtin University also allows LIWA to offer Curtin University students the opportunity of applying for LIWA scholarships and awards. I would like to thank the staff and the members of the Board for taking the Institute to the next level, and look forward to further growth and development in 2010, and indeed, over the Institute s next 10 years of activity. ABOUT LIWA CHAIRMAN S REPORT Bill Manning Chairman 8 2009 Annual Report Lung Institute of Western Australia Inc.

director s report 2009 was a year of achievement and celebration befitting our 10th Anniversary. LIWA continued to demonstrate its commitment to improving respiratory health and worked diligently to meet its objectives this year. Expanding our Organisational Structure The organisational structure of LIWA has continued to develop, with significant new initiatives to demonstrate our broadened scope of research. Three new research units were established in 2009, including the Pleural Disease Unit, the Cystic Fibrosis and Bronchiectasis Unit and the Cardiothoracic Surgery Unit. Each of these units has attracted leading clinicians and scientists to join forces with LIWA to tackle important areas of lung disease. The establishment resulted in new collaborations being made with other organisations. Other units continued to excel in the quality of research conducted, being awarded with significant grants and gaining international recognition. The Institute was also pleased to welcome LISA (Lung Impaired Support Association), a community support group, to the Institute. Now known as LIFE (Lung Information and Friendship for Everyone), this well-established group brings to LIWA much experience and understanding of supporting people living with lung disease in the community. The revised administrative staffing structure which was put into place at the end of 2008 has proved highly effective. Our new Executive Officer, Tineke Van der Eecken, brought much experience and drive to the organisation, as did Public Relations Manager, Sharon Squires-Hansen and Robyn Tandon as Memberships and PR Officer. The appointment of Finance Officer, Bi Lam, and Human Resource person Karen Coveney also resulted in significant improvements in the financial and human resource administration. Research and Collaborations LIWA s scientists continued to excel in research in collaboration with research organisations and institutes from around the world, including countries such as Japan, USA, UK, Chile, South Africa, Germany, Singapore and the Netherlands as well as local and interstate universities. New research grants were secured and significant research advances achieved. ABOUT LIWA DIRECTOR S REPORT www.liwa.uwa.edu.au 9

ABOUT LIWA DIRECTOR S REPORT Outstanding Educational Opportunities LIWA s 10th Anniversary year began with a world-class Lung and Biological Sciences Symposium, a free two day meeting held at the University Club at the University of Western Australia. LIWA attracted local, national and international delegates and speakers. The Symposium covered an innovative program with topics crossing the traditional boundaries between clinical and biological sciences and offered new insights into many areas of lung disease. The Institute s monthly Medical Research Seminar Series continued to be a popular event for clinicians and scientists. The diversity of material covered in this series demonstrates LIWA s commitment to supporting research and activities in a range of fields, from scientific imaging, to tobacco control legislation. LIWA also celebrated its 10th Anniversary by expanding its awards and scholarship opportunities to a new level. In addition to PhD Top Up scholarships, Travel Awards and Vacation Cadetships, LIWA was pleased to demonstrate its support for younger scientists, including Bachelor of Medical Science students, by introducing two new $5000 scholarships for honours students. Clinical Trials Achievements The Clinical Trials Unit continues to demonstrate its leadership in the field of clinical respiratory research within Australia, with 14 trials being conducted in 2009. These trials involved conditions such as asthma, emphysema, bronchiectasis, chronic bronchitis and influenza. New trial areas this year included cystic fibrosis and alpha 1-antitrypsin deficiency. Organisational Process Initiatives In an effort to continually improve standards, new processes were introduced and existing procedures reviewed. A significant development was the successful introduction of substantive performance review structure, which will continue to maintain and improve productivity and staff development. The Management Committee reviewed or developed policies on HR, including recruitment and selection, conference travel, and a code of ethics. Considerable investments were made to update our computer network and IT structure and adopt appropriate policies. Another significant event in terms of organisation management was the use of an Open Space type meeting which brought together all LIWA staff and interested Board members to think about how to take LIWA to the next decade of excellence. The meeting generated 13 agenda items and as many conversations, which were brought together in a Book of Proceedings. 10 2009 Annual Report Lung Institute of Western Australia Inc.

LIWA in the Community As a lead respiratory organisation in Western Australia, we are aware of the need for a unified message on lung health to reach the community. In 2009 the inaugural Breathe Easy Week was launched. This lung awareness week initiated by LIWA was supported by respiratory organisations in Western Australia such as Cystic Fibrosis WA, the Asthma Foundation of WA and the Australian Lung Foundation. The success of this event in raising awareness in the community encourages us to ensure this becomes a well-established event in the Western Australian community calendar. The establishment of our community self help group, LIFE, was a major milestone for the Institute and significantly the official launch was supported by the Health Minister the Honorable Kim Hames. LIFE is already assisting us to achieve our aim of providing support to people affected by lung disease, by encouraging self help for its members and others associated with this group. LIFE also enables community members to access information regarding respiratory issues through newsletters and regular presentations. LIWA is proud to involve the community through its membership program which allows people to remain connected with the Institute and its activities. Members receive a range of benefits including newsletters and access to educational and social events. We value our members greatly and look forward to seeing our membership base grow. Another important event was commissioning a history of LIWA s first ten years. Vannessa Hawthorn kindly took on the role of interviewing past and present staff, members and patients, and writing the story which we hope to publish in the near future. I would like to sincerely thank all staff involved with LIWA for their outstanding efforts in 2009. Their commitment, dedication and talent has enabled LIWA to once again achieve an outstanding performance of which we are all proud. Finally I would like to express my sincere gratitude to the Board. The generosity of their time and wisdom is fundamental to our success and wellbeing and is much appreciated. Winthrop Professor Philip Thompson Director ABOUT LIWA DIRECTOR S REPORT www.liwa.uwa.edu.au 11

ABOUT LIWA DIRECTOR S REPORT Director s Activities Positions held Director, Lung Institute of Western Australia. President, Thoracic Society of Australia and New Zealand. Winthrop Professor, School of Medicine and Pharmacology, University of Western Australia. Director, Centre for Asthma, Allergy and Respiratory Research, UWA. Clinical Professor, Division of Health Sciences, Curtin University. Director, CRC for Asthma and Airways Western Australian Node. Co-Director, National Health and Medical Research Council Centre of Clinical Research Excellence. Consultant Respiratory Physician, Sir Charles Gairdner Hospital. Member, Board of the Cystic Fibrosis Association of WA. Member, Board of Westcare Industries Pty Ltd. Member, Editorial Board, Respirology. Editor-in-Chief, Respirology (till April 09). UWA Vice-Chancellor Professor Alan Robson with Professor Philip Thompson, WA Chief Scientist Professor Lyn Beazley and Mr Max Kay Committee Memberships Founding member, International Medical Communications Association. Member, Asian Pacific Society of Respirology. Member, Australasian Society of Clinical Immunology and Allergy. Member, International Association for Allergy and Clinical Immunology. Fellow of the Academy of American Chest Physicians. Member, European Respiratory Society. Member, Thoracic Society of Australia and New Zealand. Member, American Thoracic Society. Member, Committee of Publishing Ethics UK. Other Activities Professor Thompson has acted as referee for the following scientific journals: American Journal of Respiratory and Critical Care Medicine; Chest; Clinical and Experimental Allergy, and Pharmacogenetics and Genomics. Professor Thompson has acted as referee for the following granting bodies: National Health and Medical Research Council; Health Research Council of New Zealand, and the Asthma and Respiratory Foundation of New Zealand. 12 2009 Annual Report Lung Institute of Western Australia Inc.

Postgraduate Students Dr Li Ping Chung PhD Ms Faang Cheah PhD Ms Hui Ling Lau PhD Ms Sally Lansley PhD (awarded) Ms Svetlana Baltic PhD (awarded) Ms Sian Turner PhD (awarded) Ms Melanie Dunn Honours Publications In 2009 13 journal articles were published. For more details, see the Publications Report. Grants Professor Thompson received funding from six grants in the 2009 period. For more details, see the Grants Report. ABOUT LIWA DIRECTOR S REPORT www.liwa.uwa.edu.au 13

board members Mr William Manning BA LLB (Qld) Chairman Mr Bill Manning holds the degrees of Bachelor of Arts and Bachelor of Law from the University of Queensland. He is admitted as a solicitor in Western Australia, Queensland, New South Wales, Victoria, England and Wales and Hong Kong and has practised in the areas of natural resources law and commercial law for the last 40 years. ABOUT LIWA BOARD MEMBERS 14 2009 Annual Report Lung Institute of Western Australia Inc. Winthrop Professor Philip Thompson MBBS FRACP FCCP MRACMA Director Professor Philip Thompson is Winthrop Professor of Respiratory Medicine at the University of Western Australia, an Adjunct Professor at Curtin University and a Consultant Respiratory Physician at Sir Charles Gairdner Hospital. He is the President of the Thoracic Society of Australia and New Zealand, immediate past Editor-in-Chief of Respirology, Director of the WA Node of the CRC for Asthma and Airways and a member of the Boards of Westcare and Cystic Fibrosis WA. He has been involved in asthma and airways research and care for respiratory patients for more than 28 years, and is recognised internationally for his work on airway pharmacology, house dust mite allergy and for his involvement in asthma therapeutics. Professor Thompson has over 240 medical and scientific publications.

Professor Lou Landau AO MBBS MD FRACP Deputy Chair Professor Landau is Emeritus Professor of Paediatrics, UWA and Chair of the Postgraduate Medical Council of Western Australia. He was Dean of the Faculty of Medicine and Dentistry from 1996 to 2004. A graduate of the University of Melbourne, Professor Landau was appointed to the Chair in Paediatrics at UWA in 1984. He was a Board member and Chairman of the Telethon Institute for Child Health Research and the Western Australian Institute for Medical Research. He received the Order of Australia in 1996 and a Centenary Medal in 2000. His varied research interests include the natural history of childhood asthma, infant lung function measurement and models of medical education. He has over 250 publications in scientific journals. Professor Michael Garlepp BSc (Hons) PhD MPS Secretary Professor Garlepp was Associate Director at the Telethon Institute of Child Health Research until the end of 2009 having previously been Professor of Pharmaceutical Biology and Head of the School of Pharmacy at Curtin University. He is a Pharmacy graduate from Curtin University and has a PhD in immunology from UWA. Postdoctoral research in Calgary, Canada, and London, UK, was followed by research appointments in the Department of Medicine UWA and at the Australian Neuromuscular Research Institute. Research interests include genetics and mechanisms of autoimmune disease, genetics and gene therapy of mesothelioma, and genetics of neurological diseases. He will continue as a half-time academic during 2010. Mr Stephen Hughes BBus ANZIIF (Fellow) LLB Dip Treasurer Mr Hughes is a general insurance broker who specialises in professional indemnity, directors and officers liability and clinical trials insurance for companies around Australia, and internationally. Stephen actively consults and provides risk management advice to directors, professionals, and corporate entities including research organisations. Prior to becoming an insurance broker Stephen was the Western Australian manager for the professional and financial services division of Royal and Sun Alliance Insurance company. Ms Sue Morey OAM FRCNA Westcare representative Ms Morey joined as a Board Member in 2007 as the Westcare representative, following our new alliance with the organisation. She has spent the last 35 years as a nurse in the Department of Respiratory medicine. In 2007 Sue completed a postgraduate degree enabling her to register and practise as a nurse practitioner in respiratory medicine. Sue has seen many changes in respiratory medicine from pulmonary TB, asbestos related diseases, better management of asthma, cystic fibrosis, and the development of lung transplantation and interventional endobronchial procedures. ABOUT LIWA BOARD MEMBERS www.liwa.uwa.edu.au 15

ABOUT LIWA BOARD MEMBERS 16 Mr James Baker BEng Dip Mr Baker is a practising Electronics Engineer. He has worked extensively as a consultant and development engineer from the Middle East to Far East Asia. He is director of his own company and is also currently the Principal SCADA Engineer with the Water Corporation of Western Australia. Dr John Bandouvakis MBBS (Hons) MRACP FRACP Dr Bandouvakis joined as a Board Member in July 2007 as the ASCIA representative. He undertook specialist training in Respiratory Medicine at Concord Hospital, Sydney and continued at Sir Charles Gairdner Hospital, after moving to Perth in 1974. Dr Bandouvaskis then worked as a research fellow at McMaster University, Canada in 1979 to 1980, obtaining further training in allergy/clinical immunology, as well as undertaking clinical research in allergic asthma and some types of occupational asthma. He returned to Perth in 1981 and commenced private practice in Allergy and Respiratory Disease. 2009 Annual Report Lung Institute of Western Australia Inc. Mr Bill Coleman AM BSocSc BJuris LLB Mr Bill Coleman was elected to the LIWA Board in January 2009. Bill holds a Bachelor of Social Sciences and a Bachelor of Jurisprudence. He retired as Chief Commissioner of the WA Industrial Relations Commission in 2004 after 20 years. Prior to this, he was secretary of the Australian Medical Association of Western Australia (AMAWA). Presently, Bill holds the position of Chairman of the Salaries and Allowances tribunal of Western Australia. He has held Board positions with other charitable organisations in Western Australia, including Diabetes WA and the Diabetes Research Foundation of WA. Winthrop Professor Gary YC Lee MB ChhB (NZ) PhD FCCP FRACP UWA Representative Professor Gary Lee is a clinician scientist renowned for translational research in pleural diseases. He is Winthrop Professor of Respiratory Medicine at the University of Western Australia, a consultant chest physician and Head of Pleural Services at Sir Charles Gairdner Hospital, Editor-in-Chief of the journal Respirology, co-editor of the International Pleural Newsletter and Head of the Pleural Disease Unit of LIWA. He has published over 100 original and invited papers and two books. He is a regular invited speaker at major international respiratory conferences and has lectured in 19 countries on topics covering both basic and clinical science of pleural diseases. He is a member of the British Thoracic Society Pleural Disease guidelines working group. Gary is the UWA representative on the LIWA Board (Aug-Dec 2009).

Ms Rachael Offer BJuris LLB BA(Eng) CFWA representative Ms Offer holds a Bachelor of Laws, a Bachelor of Jurisprudence and a Bachelor of Arts (Eng). She is currently employed by the Western Australian Land Information Authority, Landgate, as the legal counsel on Landgate s National Electronic Conveyancing System Project. She is a member of the Law Society of Western Australia and the Australian Corporate Lawyers Association. Before joining Landgate, Rachael was employed at national law firm Corrs Chambers Westgarth, practising in the Commercial Division in the areas of property, banking & finance and Local Government. Rachael has been a member of the Committee of Management of Cystic Fibrosis Association of Western Australia Incorporated (CFWA) since 2006. Mr Jesper Sentow B.Sc. (Econ) CPA MBA Mr Sentow joined the Board of LIWA in 2009. He operates his own management consultancy which specialises in corporate financial and strategic planning, restructuring and commercial improvements. He has spent over 20 years in senior financial management positions with a number of international and Australian companies including St John s Ambulance. Professor Grant Waterer MBBS FRACP Staff and UWA Representative Professor Waterer is a Professor of Medicine at UWA and Adjunct Associate Professor of Medicine at North-western University, Chicago. He is a consultant respiratory physician at Royal Perth Hospital and Head of the Infectious Diseases Unit of LIWA. He is currently the chair of the Respiratory Infectious Diseases Advisory Group for the Australian Lung Foundation, the co-chair of the American Thoracic Society Bronchiectasis Statement and clinical advisor to the Spanish Critical Care Network. He is on the editorial board of the leading pulmonary journal (the American Journal of Respiratory and Critical Care Medicine) as well as the leading spanish language respiratory journal (Medicina Respiratoria) and an associate editor for Respirology. He serves on international advisory boards for AstraZeneca, Bayer, GlaxoSmithKline and Pfizer. ABOUT LIWA BOARD MEMBERS www.liwa.uwa.edu.au 17

scientific subcommittee report Once again, the Scientific Subcommittee assessed applications for the LIWA PhD and Travel Awards. These awards support the Institute s objectives of promoting excellence in research in the area of lung disease, and providing support to medical scientists. The awards are open to applicants across Australia. The Scientific Subcommittee would like to congratulate the winners of the 2009 awards, including Ms Li Ping Chung (PhD Top Up Award), Dr Alexander Larcombe (Senior Scientist Travel Award), Ms Melanie Leffler and Ms Elizabeth Bozanich (Junior Scientist Travel Awards). ABOUT LIWA SCIENTIFIC SUBCOMMITTEE REPORT The members of the Scientific Subcommittee in 2009 were Professor Geoffrey Stewart (Chair), Professor Richard Ruffin, Professor D Arcy Holman, and Professor Michael Garlepp. Professor Steven Holgate from the University of Southampton, UK, continues to be the international corresponding member. The roles of the scientific subcommittee are to: advise the Board with respect to awarding grants and scholarships; assist the Board in determining the rules and regulations for grants and scholarships; assist the Board in finding eminent scientists to visit and / or contribute to the work of the Institute; provide advice to the Board via the Director of the Institute on the appropriateness of major expenditure on scientific equipment; and advise the Board via the Director on matters relating to scientific direction and the terms of reference for scientific reviews of the Institute. The Scientific Subcommittee also fulfils the role of the Institute s independent Research Committee. This committee takes responsibility for ensuring that research undertaken and funded by donations to the Institute is scientific in nature and that it is, or may prove to be of value, to Australia. Donations to the Institute are held in a specific research account and the Committee advises the Director and the LIWA Board on disbursement of funds from the account. The National Health and Medical Research Council (NHMRC) has approved the members of the Committee in terms of their proven ability to direct research programs as evidenced by their academic qualifications and professional appointments. Professor Geoffrey A Stewart Chair, Scientific Subcommittee 18 2009 Annual Report Lung Institute of Western Australia Inc.

education programs and initiatives LIWA continued to provide high quality educational events and opportunities to the medical and scientific community in 2009. Awards and Scholarships PhD Top Up Award Ms Li Ping Chung was awarded LIWA s PhD Top Up Award, giving her access to $8,500 per annum for three years or until submission of her thesis. Li Ping is working on the pharmacogenetics of beta 2 receptors and severe asthma. Senior Travel Award Dr Alexander Larcombe was awarded the 2009 Senior Travel Award, in recognition of his outstanding research into the effects of age of infection and sex on the acute consequences of influenza A infection at the Telethon Institute for Child Health Research (TICHR). The $3000 award allowed him to attend the American Thoracic Society (ATS) Annual International Conference in San Diego. At this conference he presented his work, attended an abundance of education sessions on advances in the field of respiratory physiology and enjoyed the opportunity to network with leaders in the respiratory community. Alexander was grateful for the opportunity to attend this meeting which would not have been possible without the assistance of the LIWA Travel Award. Junior Travel Awards LIWA recognises the need for junior scientists to attend national and international education events, and thus offers two awards per year to facilitate this. Miss Melanie Leffler and Ms Elizabeth Bozanich were awarded the Junior Medical Scientist Award of $1750 each in recognition of the excellent start that they have made in their scientific careers. Vacation Cadetships LIWA also provides a number of funded Vacation Cadetships to medicine or science undergraduate students who demonstrate exceptional talent in order to support their careers and provide experience in the research environment. Cadetships were awarded for 2009 to Ms Sarah Hayton, Mr Thomas Iosifidis, Ms Sai Baskar and Ms Sweeka Alexander. Honours Scholarships As a new addition to LIWA s scholarship and awards program during it s 10th Anniversary, we were pleased to offer the inaugural $5000 Honours Scholarships to Ms Kimberley Birnie and Ms Sarah Hayton. Education Events Medical Research Seminar Series LIWA also continued its long tradition of hosting a monthly Medical Research Seminar Series featuring high quality research conducted in Western Australia. The series of seminars helps expose clinicians and scientists to the latest advances in a diverse range of topics. ABOUT LIWA EDUCATION PROGRAMS AND INITIATIVES www.liwa.uwa.edu.au 19

ABOUT LIWA EDUCATION PROGRAMS AND INITIATIVES Presentations included the following: Professor George Yeoh (WAIMR): Liver progenitor cells Good cells or bad cells? Associate Professor Kevin Pfleger (WAIMR): Advances in the use of BRET to study G-Protein Coupled Receptor Complexes. Dr Ben Corry (UWA): Understanding ion channel selectivity and gating (and its application to the desalination of water). Dr Christopher Peacock (TICHR): The practical implications of pathogen sequencing in the genomic era. Professor Mike Daube (Curtin University): Tobacco control in Australia: why we are winning and where are the next frontiers? Ms Rachel Ramsdale (WAIMR): Molecular Discovery Systems: Western Australian Imaging and Analysis Technology, and Professor Simon Brown (RPH): Insect bites and stings: why they are so dangerous? Visiting lecturers Visiting speakers were also a highlight on the educational calendar, with Associate Professor Alaina Ammit from the University of Sydney as a visiting speaker in September. LIWA and the Raine Foundation co-hosted a presentation by Professor Richard Light of Vanderbilt University, USA in November 2009. 10th anniversary celebrations Lung and Biological Sciences Symposium LIWA s 10th Anniversary year began with a Lung and Biological Sciences Symposium on 12 13 March at the University Club, Perth, Western Australia. The event was attended by local, national and international delegates, with world-leading scientists presenting on a range of topics from both scientific and clinical fields. The diversity of the meeting as well as the standard of presentations was outstanding and LIWA is proud to consider it as the most successful symposium of its kind that Perth has hosted. In conjunction with the Symposium, LIWA held a 10th Anniversary cocktail party at Matilda Bay Restaurant, Perth, to which all LIWA members, symposium presenters and staff were invited. The Board of LIWA was pleased to acknowledge a group of long standing members at this event, particularly those who had been members since LIWA s inception. These individuals are listed later in this report. 20 2009 Annual Report Lung Institute of Western Australia Inc.

Breathe Easy Week One of LIWA s highlights of the year was the inaugural Breathe Easy Week. The aim of the week was to raise awareness of lung health in the community through a unified message from all respiratory associations in Western Australia. LIWA was proud to initiate this event which is possibly the first of its kind in Australia. In a series of festive, community-based events held from 19 23 October thousands of Western Australians were exposed to the message of the importance of maintaining lung health and ongoing respiratory research. Media promotion of the event included radio interviews with RTRfm and ABC Radio (with Bernadette Young), a feature article in the West Australian and many other local newspaper features. Many of LIWA s Lung Champions, some of whom have experienced the life-changing benefit of LIWA s clinical input, were enthusiastic supporters and participants of the week. Free lung testing, live entertainment and an improved awareness of lung health were just some of the benefits of the week. Events included: Launch event in Kings Park, with local TV presenter Dixie Marshall as MC and Marc Cain performing. Walk for Lung Health with indigenous women, co-hosted by Community Vision. Jazz in the city, a free jazz concert in Perth s Murray Street Mall, with well known performer Libby Hammer and her Jazz Quartet. Breathe Easy Open Day with displays from respiratory organisations including the Asthma Foundation and Cystic Fibrosis WA, and Bow Tie and Boa Feather fundraising dinner, with Honourable Chief Justice, Wayne Martin, as guest speaker and local media presenter Geraldine Mellet as MC. ABOUT LIWA 10TH ANNIVERSARY CELEBRATIONS www.liwa.uwa.edu.au 21

ABOUT LIWA LIWA IN THE COMMUNITY LIWA in the community 2009 saw LIWA extend its reach into the community by holding many events to involve the community as well as welcoming a well-established community support group on board. LIFE: Community Support Group In August 2009, LIWA launched LIFE, a community support group. The background of this group can be found in this new unit s report. Dr Kim Hames, the Deputy Premier and the Western Australian Minister for Health and Indigenous Affairs, officially launched the group. We look forward to the mutual support and benefit that will come of our two groups joining forces. Wine Soiree LIWA members, staff and guests enjoyed a free culinary evening with free tasting of wine, cheese, olives and olive oil from local producers. The September event was a great opportunity for guests to enjoy good company while learning more about the products on show. Support for the arts: Toogarr Morrison Exhibition LIWA demonstrated its support for the arts with sponsorship of an exhibition by local indigenous artist Toogarr Morrison. Toogarr s educational art work was displayed in the Moores Building in Fremantle, Western Australia, with LIWA providing in kind support for the artist. Image courtesy of Toogarr Morrison 22 2009 Annual Report Lung Institute of Western Australia Inc.

Melbourne Cup Lunch for Cystic Fibrosis A new alliance between LIWA and a small group of fundraising champions saw LIWA support a highly successful fundraising lunch on Melbourne Cup day to raise funds for Cystic Fibrosis and Infectious Disease research. Ably coordinated by Ms Janeine Thomas, Ms Alison Guest and Ms Carmel Rankin, this event was extremely popular with over 160 guests enjoying fine food and wine and the spirit of the day, whilst raising funds for a good cause. We are sincerely grateful for the funds they raised as a result of this event. Supporters Christmas Lunch Each year LIWA hosts a Christmas lunch for members, supporters and CTU patients. Over 70 people attended this social event in 2009. World COPD Catch your Breath Walk The Annual COPD Day Catch Your Breath Walk was proudly supported by LIWA this year. Over 40 people from Charlies Easy Breathers and LIWA members and staff added 64.7km to the national tally. Many of the walkers have difficulty achieving a 50m walk due to advanced lung disease; their active participation inspired many. ABOUT LIWA LIWA IN THE COMMUNITY www.liwa.uwa.edu.au 23

THE WEST AUSTRALIAN WEDNESDAY, MARCH 11, 2009 41 advertising feature Prof Philip Thompson Over the past ten years, LIWA has become recognised nationally and internationally for its holistic approach to medical research and patient care. The Institute has had outstanding achievements in its research efforts to better understand the complexities of lung disease and in its desire to help patients not responding to standard care. LIWA believes and promotes an integrated approach in its research of respiratory and allergic diseases. We aim to work with patients, to keep them better informed, and to apply the latest advances and developments to treat lung disease. In 2009 and beyond, our scientists, doctors and nurses will continue to Make a Difference by adding value to the community, by increasing our knowledge and understanding of lung disease, and by improving our patients' 'breath of life'. Today, we thank all those who have been part of our story. Fact: One in four families are affected by lung disease. Fact: Only one in four businesses in Australia truly succeed and realize all of their goals. Is your business delivering the results you seek in these challenging times? Can you afford not to know the health of your business right now? Hon Dr Kim Hames MBBS JP MLA Deputy Premier; Minister for Health; Indigenous Affairs The Lung Institute of Western Australia Incorporated (LIWA) is part of this proud tradition and I congratulate you on reaching this significant milestone of 10 years of 'Making a Difference'. As one of only two research institutes in Australia dedicated specifically to investigating lung disease, LIWA plays a very important role in improving the well-being of patients and providing a strong educational resource for the community at large. With my dual responsibilities in health and indigenous affairs, I am pleased to note that LIWA intends to focus on respiratory health in our indigenous population in the future. I wish you well in your birthday celebrations. www.abbottsolutions.com.au (08) 9272 8611 Moving your Business from Good to Great! May 25th to May 28th 2009, Bunker Bay Resort Margaret River WA. ABOUT LIWA LIWA IN THE COMMUNITY LIWA in the news LIWA raised its profile in the community in 2009 through regular features in the media. In addition to the great coverage received during Breathe Easy Week in both radio and newspaper, LIWA provided expert opinion on a range of issues, including the swine flu outbreak, respiratory effects of bush fires and the effects of air pollution on lung disease. LUNG INSTITUTE OF WESTERN AUSTRALIA DIRECTOR S MESSAGE This year marks the 10th anniversary of the Lung Institute of Western Australia (LIWA). Breathtaking should be a good thing. Abbott Solutions partner with clients to enhance the performance of their business making it more pro table, valuable and enjoyable. BREATH OF LIFE MESSAGE FROM THE MINISTER With two Nobel medicine laureates and some of Australia s brightest scientific minds, WA has a proud tradition of excellence in medical research. healthier for the experience The story of Janine Ban The philosophy of LIWA is that everyone who comes into contact with the Institute should be better informed and healthier for the experience. This was certainly the case when Janine Ban came into contact with the Institute eight years ago. Janine Ban is an accomplished talented ballet dancer, who today teaches and mentors as the principal of one of Perth s top ballet schools the Perth School of Ballet. Anyone who meets Janine would not know that she has suffered from life threatening asthma since she was a young girl, however despite suffering from this disease she has never let it affect her passion to pursue a career in dancing or effect her performance in this arena. Despite her debilitating condition, with the love and support of her parents, she was encouraged to lead an active and normal childhood, and started training in classical ballet at a very early age. Her enthusiasm for a serious career in dance saw her leave school to audition for a full-time course at the WA Academy of Performing Arts. At the same time she also undertook private training with the Bonny Parker School of Classical Ballet. It was during this period that she realised how difficult it was going to be living with a chronic lung condition. 24 2009 Annual Report Lung Institute of Western Australia Inc.

MAKING A DIFFERENCE Apart from the difficulty of keeping up with the physical demands on her body, she also found it difficult and impractical to take her regular medications and nebuliser treatments in the middle of a dance studio. At this point, Janine s health was fast deteriorating, and she had to leave the course months before graduating. However, despite this set back she did achieve her goal and later qualified in her final performing exams and teaching degree with distinction. At the age of 19 she was offered an amazing opportunity, to run the Bonny Parker School of Classical Ballet. She joined forces with her close friend Simone Jackson-Pike to form what is today known as the Perth School of Ballet. One of the most significant turning points in Janine s life was when she was offered the opportunity to be under the care of Professor Philip Thompson, Director of LIWA. Janine said: I first met Professor Thompson as a young adult when my future was looking extremely grim with an average of six months of every year being spent critically ill in hospital. It has been the amazing ongoing research of LIWA, overseen by Professor Thompson, that led to a major break-through treatment (Xolair) for my chronic asthma. This has helped improve my lifestyle, particularly by shortening my hospital stays and allowing me to return to my passion in life ballet teaching. I hope that in the future the amazing research and work of LIWA will be supported so that everyone becomes aware of the implications of lung disease a condition that can be quite silent and often misunderstood by society. This will hopefully lead to even more treatments for the prevention and cure of the many lung diseases that exist in our community. Janine, right, with LIWA supporters at the Bow Tie and Boa Feather Dinner Janine Ban, stage centre, enjoys a healthier life ABOUT LIWA LIWA IN THE COMMUNITY www.liwa.uwa.edu.au 25

UNIT REPORT TISSUE REPAIR unit report Biological ScienceS Tissue Repair Many forms of lung disease can be regarded as the interaction between tissue injury and the subsequent attempts to heal the tissues affected. Associate Professor Steven Mutsaers leads a team of scientists committed to assessing the mechanisms regulating interactions between cells, the matrix surrounding cells and the different molecules released following injury. These interactions can stimulate cells to respond in different ways, including cell proliferation, migration, invasion, differentiation and collagen production. Diseases arising from abnormal tissue repair include pulmonary fibrosis, adhesions and malignant mesothelioma. The focus of their work is in two areas. Firstly they are studying the mechanisms underlying mesothelial healing and the role of the mesothelial cell and mesothelial stem cell in normal repair; the formation of post-operative adhesions; and the factors which regulate the development and growth of malignant mesothelioma. Particular interest has recently focused on the role of developmental genes and the growth factor transforming growth factor beta in mesothelioma growth and how mesothelial and mesothelioma cells can differentiate into other cell types. Secondly, they are investigating how lung injury can lead to the development of fibrosis (scar tissue in the lung), in particular the role of the interleukin-6 family of cytokines and the molecules that regulate their signaling pathways. Staff Associate Professor Steven Mutsaers BSc. (Hons) PhD Head of Unit; Senior Medical Scientist PathWest Laboratory Medicine WA; Senior Research Scientist LIWA; Adjunct Associate Professor, CAARR, UWA Dr Cecilia Prêle BSc (Hons) PhD Senior Research Scientist; Adjunct Senior Lecturer CAARR, UWA Dr Bahareh Badrian BSc (Hons) PhD Postdoctoral Research Scientist; Adjunct Lecturer, CAARR, UWA Dr Robert O Donoghue BSc (Hons) PhD Postdoctoral Research Scientist Dr Kamali Pugazhenthi BSc MSc Dip Grad. PhD Postdoctoral Research Scientist Dr Sally Lansley BSc (Hons) PhD Postdoctoral Research Scientist (until May 2009) Ms Rosie Gulliver BSc (Hons) Research Assistant Ms Hui Min Cheah BSc (Hons) Research Assistant Ms Sabine Matthaes Dipl Biol Research Assistant Awards Ms Hui Ling Lau, Finalist for TSANZ Young Investigator Award 2009. Ms Hui Ling Lau, Finalist for SCGH Young Investigator Award 2009. 26 2009 Annual Report Lung Institute of Western Australia Inc.

Grants Please refer to the Grants Report for details of the grants that the Unit has been awarded. Positions Held Mutsaers, S. Secretary, Executive Committee International Mesothelioma Interest Group. Mutsaers, S. Member, Scientific Advisory Board Mesothelioma Applied Research Foundation. Mutsaers, S. Member, Grant Review Panel National Health and Medical Research Council. Prêle, C. Member, Laboratory Research Advisory Committee School of Medicine and Pharmacology, UWA. Badrian, B. Member, Computing Committee University Department of Medicine, UWA. O Donoghue, R. President, WA Branch Thoracic Society of Australia and New Zealand Associates Committee. Miranda, A. National Treasurer, National Executive, Australian Society of Cytology Inc. Presentations and Chairmanship International Mutsaers, S. The mesothelial cell. Surgical Humidification Research Forum. Fisher & Paykel Healthcare, Auckland, New Zealand. Mutsaers, S. From mesothelial injury to adhesion formation. Hernia and Peritoneal Adhesion Conference, Rotterdam, the Netherlands. Mutsaers, S. The mesothelium, more than just a slippery surface. and The mesothelial stem cell, fact or fiction. Fisher & Paykel Healthcare, Auckland, New Zealand. National Mutsaers, S. Session Chair. Thoracic Society of Australia and New Zealand Annual Scientific Meeting. Darwin, NT. Badrian, B. Transforming growth factor ß-signalling pathway in malignant mesothelioma growth and collagen production. National Centre for Asbestos Related Disease (NCARD) Annual Meeting. Sydney, NSW. Local Mutsaers, S. The mesothelial stem cell, fact or fiction? Translational Medicine Symposium. Yallingup, WA. Mutsaers, S. Session Chair, 6th Perth Mesothelioma Centre Symposium. Sir John of God Hospital, Subiaco, Perth, WA. Lau, HL. The IL-6 Family of Cytokines Modulate Bleomycin-Induced Lung Fibrosis. TSANZ Young Investigator Award. Thoracic Society of Australia and New Zealand Western Australia Branch Annual Meeting. Mandurah, WA. Lau, HL. The IL-6 Family of Cytokines Modulate Bleomycin-Induced Lung Fibrosis. SCGH Young Investigator Award. Sir Charles Gairdner Hospital Research Committee. SCGH, Nedlands, Perth, WA. UNIT REPORT TISSUE REPAIR www.liwa.uwa.edu.au 27

UNIT REPORT TISSUE REPAIR Referees Steven Mutsaers has acted as a referee for American Journal of Pathology, American Journal of Respiratory Cell and Molecular Biology, American Journal of Respiratory and Critical Care Medicine, Biotechnology Progress, Cell and Tissue Research, European Respiratory Journal, Human Reproduction, International Archives of Allergy and Immunology, International Journal of Biochemistry and Cell Biology, Journal of Clinical Investigations, Pulmonary Pharmacology and Therapeutics, Respirology, NHMRC, Mesothelioma Applied Research Foundation, Asthma Foundation, Murdoch Children s Research Institute, Australian Lung Foundation, Cancer Council of WA and NSW Dust Disease Board. Kamali Pugazhenthi has acted as a referee for Wound Repair Regeneration and Cell Biochemistry and Function. Student Activities Ms Alina Miranda (PhD). MUC1 in the diagnosis and pathogenesis of malignant mesothelioma. Supervisors J Creaney, A Nowak, S Mutsaers. Ms Hui Ling Lau (PhD). The Role of the IL-6 Family of Cytokines in Bleomycin-Induced Fibrosis and IPF. Supervisors S Mutsaers, P Thompson. Ms Robyn Jones (PhD). Airway smooth muscle cell hypertrophy and hyperplasia in asthma and COPD. Supervisors A James, S Mutsaers. Ms Eve Ngoh (Hons). The role of the hedgehog signalling pathway in malignant mesothelioma growth. Supervisors S Mutsaers, C Thomas, R Mead. Collaborations International Dr Darryl Knight, James Hogg, icapture Centre, Vancouver, Canada. Professor Geoffrey Laurent, Centre for Respiratory Research, University College London, UK. Regulation of gp130-signaling pathways in idiopathic pulmonary fibrosis. Dr David Riches. National Jewish Health, Denver, USA. Provision of IPF cells. Dr Gisela Lindahl. Royal Free Hospital, London, UK. Provision of lung scleroderma cells. Dr Sarah Herrick. Manchester University. Plasticity of mesothelial cells. Dr Astrid Haegens and Dr Juanita Vernooy. Nutrition and Toxicology Research Institute Maastricht, University of Maastricht, the Netherlands. Role of myeloperoxidase in acute lung inflammation and epithelial injury. Dr Wang Zhibo and Associate Professor Michael Raghunath. Division of Bioengineering and Biochemistry, National University of Singapore. Role of histone deacetylases in scar formation. National Professor Matthias Ernst, Dr Andrew Jarnicki, Dr Robert O Donoghue, Ludwig Institute for Cancer Research. Professor Gary Anderson, Ms Jessica Jones and Dr Hong-Jian Zhu, Melbourne University, Melbourne. gp130-signaling pathways in bleomycin-induced lung fibrosis in gp130-mutant mice. Dr Sandra Nicholson. Walter and Eliza Hall Institute, Melbourne. SOCS1 signaling in activated human monocytes and macrophages. Professor Neil Watkins. Monash University, Melbourne. Hedgehog signaling pathways in malignant mesothelioma. 28 2009 Annual Report Lung Institute of Western Australia Inc.

Local Professor Prue Hart. Telethon Institute for Child Health research, Perth. SOCS1 signaling in activated human monocytes and macrophages. Professor Bruce Robinson, Associate Professor Richard Lake, Dr Cleo Robinson and Ms Ivonne van Bruggen. Department of Medicine UWA. Plasticity of malignant mesothelioma cells. Dr Terry Robertson. Curtin University, Bentley. The role of hepatocyte growth factor in serosal repair and adhesion formation. Inflammation / Immunology / Cancer Research in the Inflammation / Immunology / Cancer Unit is focused on inflammatory mediators (the kallikrein-kinin cascade, prostaglandins, leukotrienes), immune modulation of dendritic cells, the effects of air pollution on lung cells and human lung cancer. The projects are focused on inflammatory cells (eosinophils, neutrophils, macrophages) and dendritic cells, and the regulatory enzymes, mediators and receptors that may be important in the pathophysiology of asthma and COPD. In addition, there is increasing evidence of an association and interdependence between the immune and nervous systems. Recent evidence has shown that dendritic cells produce a number of neuropeptides, of which -synuclein is featured by the Unit. Recent evidence increasingly supports the view that the serine proteases (kallikreins) and mitogenic peptides (kinins) exert important control on the invasiveness and metastasis of tumours in cancer cell biology, and this has led to the research on their importance in lung cancer. The novel approach, in a newly emerging and important aspect of tumour biology, of dissecting DNA methylation and histone acetylation of the kallikreinkinin genes, together with studies on the effects of these modifications on the migration, proliferation and apoptosis of lung cancer cells, may have important therapeutic implications. There are two primary areas of focus within the Unit: Inflammation and Cancer Research Group, including: Cancer of the lung and pleura, Role of the kallikrein-kinin cascade proteins in neovascularization of lung tumours, and Volatile organic compounds as potential biomarkers of asthma. Immunology and Dendritic cells group, including: Effects of kinins on dendritic cell phenotype, Neuroimmunology Expression and function of -synuclein in human dendritic cells, and Effect of statins on migration of dendritic cells and their importance in asthma therapy. Staff Professor Kanti Bhoola MBBCh BAO BSc (Hons) MD PhD Head of Unit; Adjunct Professor, UWA; Hon Professor University of Witwatersrand, Johannesburg, South Africa Dr Neil Misso BSc PhD Senior Scientist, Adjunct Senior Lecturer, UWA Dr Mirjana Fogel-Petrovic BSc MS PhD Senior Scientist, Adjunct Senior Lecturer, UWA Dr Shashi Aggarwal MSc PhD Research Officer Ms Odette Shaw BSc (Hons) Research Assistant Mr Joshua Wong BSc (Hons) Ms Yee Yen Sia BSc (Hons) UNIT REPORT INFLAMMATION / IMMUNOLOGY / CANCER www.liwa.uwa.edu.au 29

UNIT REPORT INFLAMMATION / IMMUNOLOGY / CANCER Awards Professor Kanti Bhoola. Art and Science of Medicine Gold Award in recognition of his pursuit of excellence in scientific research, South African Medical Association. Professor Kanti Bhoola. Thoracic Society of Australia and New Zealand Slater and Gordon International Mesothelioma Travel Grant 2009. Professor Kanti Bhoola. Thoracic Society of Australia and New Zealand Maurice Blackburn Lawyers International Travel award 2009. Grants Please refer to the Grants Report for details of the grants that the Unit has been awarded. Positions Held Misso, N. Member, Research Subcommittee Asthma Foundation of WA. Misso, N. Member, Laboratory and Research Advisory Committee UWA School of Medicine and Pharmacology, SCGH Unit. Presentations and Chairmanship Bhoola, K. Epigenetic regulation of human lung cancer. Seminar, Medical School, University of Witwatersrand, Johannesburg, South Africa, June 2009. Bhoola, K. Networking Molecular Mechanisms in lung cancer. Associate Professor Ann Lee Siew Gek, Molecular Biology Department, National Cancer Centre Singapore, November 2009. Misso, N. Effects of ambient particulate matter on cytokine production by dendritic cells and macrophages. LIWA Lung and Biological Science Symposium, Perth, WA, March 2009. Fogel-Petrovic, M. Session Chair, ASMR Medical Research Week Symposium, Curtin University, Bentley, WA, June 2009. Referees Professor Kanti Bhoola has acted as a referee for Biochemical Journal, Journal of Leukocyte Biology, British Journal of Dermatology, International Pharmacology, Biomarkers in Medicine, Journal of Immunology, Diabetes and Metabolism and on Granting bodies for Cancer Research UK, British Lung Foundation, and the Mick-Knighton Mesothelioma Research Fund. Dr Neil Misso has acted as a referee for British Journal of Nutrition, Clinical and Experimental Pharmacology, and Physiology. Dr Mirjana Fogel-Petrovic was a reviewer for the NHMRC. Student Activities Dr Svetlana Baltic (PhD). A role of neuroprotein -synuclein in human DC. Supervised by M Fogel- Petrovic, PJ Thompson. PhD awarded. Mr Raymond Motadi (PhD). Gentic regulation and molecular mechanisms of apotosis in lung cancer: a role for retinoblastoma binding protein 6 (RBBP^) and its protein products. Supervised by Z Dlamini, K Bhoola. PhD awarded. 30 2009 Annual Report Lung Institute of Western Australia Inc.

Ms Rosie Gulliver, BSc (Hons). Role of bradykinin and des arg- bradykinin on mature DC migration. Supervised by M Fogel-Petrovic. Mr Joshua Wong, BSc (Hons). Expression and epigenetic regulation of the kallikrein and kinin receptor genes in mesothelioma. Supervised by K Bhoola, N Misso. Ms Yee Yen Sia, BSc (Hons). Expression and epigenetic regulation of kallikrein and kinin receptor genes in lung carcinoma lines. Supervised by K Bhoola, N Misso. Collaborations Professor Carlos Figueroa. Austral University of Chile. Kinin B1 receptor stimulation in human neutrophils. Dr L Reddy. Durban University of Technology, Durban, South Africa. Anti-cancer plant products. Professor Johanna Plendl. Free University of Berlin. Lung cancer: Activation of stem cells by tissue kallikrein and kinins to form vascular lifelines. Dr Igor Konstantinov, Dr Pankaj Saxena, Dr Jurgen Passage, Mr Mark Newman. Cardiothoracic Surgery, Sir Charles Gairdner Hospital, WA. Molecular Genetics The Genetics Unit of LIWA is dedicated towards identifying the genetic basis of respiratory diseases, including asthma and COPD. Although these conditions often arise as a result of environmental exposure, genetic variations within an individual may contribute significantly to both disease susceptibility and severity, explaining, for example, why some smokers develop COPD while others do not. The main focus of the Genetics Unit, through its involvement with the nation-wide Co-operative Research Centre (CRC) for Asthma and Airways, is to identify genetic differences between healthy individuals and those with respiratory disease, with the aim of developing diagnostic kits to identify patients at risk of developing disease, as well as discovering new targets for the development of more effective treatments for these diseases. One research focus has been to employ high-throughput genotyping technology to examine associations between single nucleotide mutations and disease development and severity, with a view to identifying genes contributing to each of these conditions. This work has provided useful information about the genes contributing to airway inflammation in disease processes, allowing more focused analysis of key genes. UNIT REPORT MOLECULAR GENETICS www.liwa.uwa.edu.au 31

UNIT REPORT MOLECULAR GENETICS A major new research focus of the Genetics Unit is modulating gene expression in disease using cuttingedge techniques. The Unit is primarily investigating alternative splicing, a process whereby a single gene can produce multiple proteins, often with different biological functions. Changes in alternative splicing have been associated with several human diseases, although the role of aberrant splicing in respiratory disease has not been thoroughly investigated. In collaboration with Professor Steve Wilton and Adjunct Professor Sue Fletcher, world-renowned experts in the area of alternative splicing in disease development, the Genetics Unit is aiming to identify aberrant alternative splicing events that contribute to disease development. Further, by using state-of-theart antisense oligonucleotide technology to correct aberrant splicing or manipulate expression of genes, the Unit aims to develop effective genetic therapies for these conditions, improving patient quality of life and decreasing the burden of respiratory disease. Staff Winthrop Professor Philip Thompson MBBS FRACP FCCP MRACMA Head of Unit Dr Svetlana Baltic PhD MSc BSc (Hons) Senior Research Officer Dr Chalermchai Mitrpant PhD MB Research Officer Ms Jing Shi BSc MSc Research Officer Mr Brad Shelton BSc (Hons) Research Officer Awards Dr Svetlana Baltic. Thoracic Society of Australia and New Zealand Travel Award 2009. Grants Please refer to the Grants Report for details of the grants that the Unit has been awarded. Positions Held Shelton, B. Secretary, Thoracic Society of Australia and New Zealand Western Australia Branch. Baltic, S. Member, Western Australian Institute of Medical Research Cryofacility. Baltic, S. Member, Thoracic Society of Australia and New Zealand Western Australia Branch. Presentations and Chairmanship Thompson, PJ. The role of splice variants in gene expression. CRC for Asthma and Airways Conference, Sydney, NSW, June 2009. Baltic, S. The role of -synuclein splice variants in dendritic cells, LIWA 2009 Lung & Biological Science Symposium, Perth, WA, April 2009. Baltic, S. -syn in Dendritic Cells, Lung Research Group meeting, November 2009. Shelton, B. Chaired Plenary Session at Thoracic Society of Australia and New Zealand Western Australia Branch Annual Meeting, Mandurah, WA, November 2009. Baltic, S. Chaired the Clinical Updates Session at Thoracic Society of Australia and New Zealand Western Australia Branch Annual Meeting, Mandurah, WA, November 2009. 32 2009 Annual Report Lung Institute of Western Australia Inc.

Student Activities Dr Li Ping Chung MB BS, FRACP (PhD). Pharmacogenetics of severe asthma: beta 2 adrenergic receptor polymorphisms alter receptor and function leading to differential clinical response to beta 2 agonists. Supervised by PJ Thompson, G Waterer. Ms Faang Cheah BSc (Hons) (PhD). Characterisation of kinin B1 receptor expression in human lung cells. Supervised by PJ Thompson, K Bhoola. Ms Melanie Dunn BSc (Hons). Variations in e-prostanoid receptor expression in the respiratory tract. Supervised by S Baltic, PJ Thompson. Collaborations Professor Johanna Plendl and Dr Sabine Kaessmeyer from Free University of Berlin and Professor Kanti Bhoola. Group of Eight (GO8) UWA project. Investigate the Influence of lung cancer cells on the formation of capillary vessels arising from lung microvascular endothelial cells when in co-culture-the newly formed vessels differ in the expression of the kallikrein cascade and the progenitor and stem cell markers. Decode Genetics Iceland genome wide scanning for asthma genes. CRC for Asthma and Airways. Pleural Disease Unit The Pleural Disease Unit focuses on translational research of common pleural diseases, especially pleural infection and malignancies. Our research program covers a wide range of laboratory research and clinical studies, from cellular and molecular responses of mesothelial cells in diseases to in vivo models and to clinical trials of new diagnostic tests or treatments. Active work on pleural infection includes laboratory studies on effect of different bacteria on mesothelial cells and development of a new model of pleural infection. These are funded by the Raine Foundation of Western Australia and Medical Research Council, UK. Professor Gary Lee is a co-investigator of multicentre clinical studies of novel treatments for pleural infection, such as the British Thoracic Society Multicentre Intrapleural Sepsis Trial-2. Malignant pleural effusions can complicate most cancers, and produce disabling symptoms. The Pleural Disease Unit has active laboratory projects on identifying key molecules governing malignant pleural pathologies and their application in clinical settings as well as studies evaluating new pleurodesing agents. Supported by the SHRAC of the WA Health Department, Professor Lee leads a study on investigating the cost effectiveness of different management strategies of malignant effusion. Professor Lee is also a co-investigator of a British Lung UNIT REPORT PLEURAL DISEASE UNIT www.liwa.uwa.edu.au 33

UNIT REPORT PLEURAL DISEASE UNIT Foundation-funded randomised study comparing the use of indwelling pleural catheters versus conventional pleurodesis in managing malignant pleural effusions. Staff Winthrop Professor YC Gary Lee MBChB PhD FRACP FCCP Head of Unit Dr Sally Lansley BSc PhD Post-doctoral Scientist (from May 2009) Dr Edward Fysh MBBS Clinical Research Fellow Ms Ai Ling Tan BSc Research Assistant Ms Kate McCartney RN Research Nurse Mr Mike Zachar RN Research Nurse Mr Mark Evans RN Research Nurse Ms Sharifa Dina RN Research Nurse Awards Winthrop Professor Gary Lee (and Professor Richard Light). First Prize (Respiratory book section), British Medical Association Medical Books Competition Awards 2009. Grants Please refer to the Grants Report for details of the grants that the Unit has been awarded. Positions Held Lee, YCG. Member, British Thoracic Society Pleural Disease Management Guidelines Panel. Lee, YCG. Editor, International Pleural Newsletter. Lee, YCG. Editor-in-Chief, Respirology. Lee, YCG. Member, Asian Pacific Society of Respirology Executive Committee. Lansley, S. Education representative, Postgraduate Committee University Department of Medicine, UWA. Presentations and Chairmanship International Lee, YCG. Biomarkers. British Thoracic Society Annual Winter Conference, London, UK, December 2009. Lee, YCG. Pleural Effusion: Diagnosis and Management. Hong Kong Thoracic Society Autumn Seminar, Hong Kong, November 2009. Lee, YCG. Why clinicians should do research, and why they must publish. Asian Pacific Society of Respirology Annual Congress, Seoul, Korea, November 2009. Lee, YCG. Light s Criteria outdated approach. American College of Chest Physicians (CHEST) Conference, San Diego, USA, November 2009. Lee, YCG. Advances in biomarkers. American College of Chest Physicians (CHEST) Conference, San Diego, USA, November 2009. Lee, YCG. Small bore chest tubes: Small size big indications? American Association for Bronchology & Interventional Pulmonology (17th Annual Assembly) San Diego, USA, November 2009. 34 2009 Annual Report Lung Institute of Western Australia Inc.

Lee, YCG. Translational Advances Diagnosis of Pleural Infection. American Thoracic Society International Conference, San Diego, USA, May 2009. Lee, YCG. Pleural Fluid Drainage. American Thoracic Society International Conference, San Diego, USA, May 2009. Lee, YCG. Pleural Diseases. American Thoracic Society International Conference, San Diego, USA, May 2009. Lee, YCG. Significance of Malignant Pleural Disease. Approach to Pleural Cancers: State-of-the-Art. European School of Oncology, Athens, Greece, May 2009. Lee, YCG. Pleural Infectious Diseases The Truth. 10th International Symposium (Endoscopy) Leuven, Belgium, March 2009. Lee, YCG. Keynote speaker: Diagnosis and Management of Pleural Effusions ; Pneumothorax ; Pleural Infection: Controversies & Advances ; Should Clinicians Perform Research? Indian Medical Association (Mumbai West Branch) Pleural Workshop, Mumbai, India, February 2009. Lee, YCG. Keynote Speaker: Diagnosis and Management of Pleural Effusions ; Pleural Infection: Controversies and Advances ; Meet the Expert Session. Association of Chest Physicians (West Bengal) 12th Annual Conference, Kolkata, India, February 2009. National Lee, YCG. Pleural Infection. Thoracic Society of Australia and New Zealand Annual Scientific Meeting, Darwin, NT, April 2009. Lee, YCG. Difficult Case Drop In Pleural Disease. Thoracic Society of Australia and New Zealand Annual Scientific Meeting, Darwin, NT, April 2009. Local Lee, YCG. Translational Research in Pleural Infection. Princess Margaret Hospital Respiratory Research Group Annual Retreat, Rottnest Island, WA, November 2009. Lee, YCG. Pleural Disease Update. Thoracic Society of Australia and New Zealand, Western Australia Branch meeting. Mandurah, WA, November 2009. Lee, YCG. Translational Advances in Pleural Diseases. Lung and Biological Science Symposium, Lung Institute of Western Australia. Perth, WA, March 2009. Referees Winthrop Professor Gary Lee is a referee for American Journal of Respiratory Critical Care Medicine; British Medical Journal; BMJ Monograph; Chest; International Journal of Medicine and Medical Sciences; Journal of Bronchology; Respirology; Technology in Cancer Research and Treatment and Thorax. Collaborations University of Oxford (Oxford Pleural Unit). University College of London (Centre for Respiratory Research). University of Athens (Dr Kalomenidis group at Thorax laboratory). University of Bristol (Dr Maskell s pleural research group). UNIT REPORT PLEURAL DISEASE UNIT www.liwa.uwa.edu.au 35

MAKING A DIFFERENCE UNIT REPORT CLINICAL TRIALS UNIT unit report Clinical Sciences Clinical Trials Unit The Clinical Trials Unit is a purpose built unit dedicated to the formal scientific evaluation of the clinical benefits of new respiratory therapies and patient education. The Unit is the public face of LIWA and is where the public involved in research come into contact with the staff of the Institute. The Unit is well equipped and has an extensive patient database which ensures high productivity of clinical research. Trial coordinators come from a range of disciplines including sciences, healthcare research, and nursing, ably supported by our own clinical trials doctors. All research staff have extensive experience in clinical research as well as a high level of knowledge in respiratory disease. This year, the Unit has participated in 14 clinical trials sponsored by a range of Australian and international pharmaceutical and biotech companies in asthma, emphysema, chronic bronchitis, bronchiectasis, and influenza. Also this year, we have attracted clinical trials in cystic fibrosis and alpha 1-antitrypsin deficiency which is a first for the Unit. In addition to the extensive range of sponsored clinical studies, the Unit has again played a pivotal role in supporting research being undertaken by other Units within the Institute. The Unit has maintained a collaborative relationship with respiratory physician, Dr Peter Bremner, who is based at St John of God Hospital, Subiaco. Many hundreds of people have been seen in the Clinical Trials Unit this year, including some patients who primarily attend in order for us to improve their health. This is a direct outcome of the Institute s motto that everyone who comes in contact with the Institute should be healthier and better informed for the experience. Staff Ms Michelle Davies BSc RN Head of Unit Dr Kevin Tan MBBS Research Physician Dr Li Ping Chung MBBS FRACP Research Physician Ms Meagan Shorten BSc Study Coordinator Ms Charlotte Hall RN Research Nurse Ms Tracey Shanks RN Research Nurse Ms Rachel Beard RN Research Nurse Dr Peter Bremner MB ChB MD FRACP Respiratory Physician Winthrop Professor Philip Thompson MBBS FRACP FCCP MRACMA Principal Investigator 36 2009 Annual Report Lung Institute of Western Australia Inc.

Pulmonary Vascular and Advanced Lung Disease Our principle areas of investigation relate to serious lung disease, lung transplantation and pulmonary arterial hypertension (PAH). In the area of lung transplantation, we are interested in the role that donor specific antibodies have in the development of acute and chronic graft dysfunction. We are examining groundbreaking immunosuppressant therapies to inhibit the development of graft dysfunction whilst at the same time minimising the side effects from immunosuppression. We are also looking closely at the psychological impact of transplantation on our patients and their families. In the area of serious lung diseases, we are involved in clinical trials of novel therapies in interstitial lung disease and bronchiectasis. We are part of an Australian collaborative effort examining new therapies in scleroderma associated interstitial lung disease. In the area of pulmonary hypertension (PH), we are involved in several clinical trials examining novel medications and indications for therapy. We have published the results from the first Australian study examining the benefits of screening patients with scleroderma for pulmonary vascular and parenchymal lung disease, receiving international recognition for this. Having established its safety, we are now the first group to perform a randomised controlled trial of an outpatient based exercise rehabilitation program on outcomes in PAH. We are systematically examining barriers to early diagnosis of PAH and are involved in teaching colleagues from across Asia and showcasing our Unit as an example of one of the leading expert centres in PAH throughout the world. We have gained international attention as one of the world leading centres in examining the role of exercise measurements and quality of life in the diagnosis of PAH and in assessment of its severity. We are the first group to have validated a disease specific measure of quality of life in patients with PAH for the Australian community and are using this newly validated tool in the assessment of PAH. Pulmonary hypertension can also complicate other diseases especially COPD and Interstitial Lung Disease. We are using novel methods to analyse the impact that the development of PH has in these conditions on survival, exercise capacity, quality of life, and utilisation of healthcare resources. Staff Associate Professor Eli Gabbay MBBS FRACP Head of Unit Dr Michael Musk MBBS FRACP Respiratory Physician Dr Kevin Gain B Med Sci PhD Ms Sharon Lawrence Clinical Nurse Ms Corina Jary Clinical Nurse Dr Kylie Hill BSc (Physiotherapy) PhD Post Doctoral Fellow Awards Ms Robin Fowler. Thoracic Society of Australia and New Zealand National Ann Woolcock Young Investigator Award Finalist 2009. Associate Professor Eli Gabbay and Ms Robin Fowler. Royal Perth Hospital Young Investigator Award, Encouragement Award 2009 for their work on Exercise induced rise in pulmonary pressures are clinically important and reflect the presence of a pulmonary vasculopathy. UNIT REPORT Pulmonary Vascular and Advanced Lung Disease www.liwa.uwa.edu.au 37

UNIT REPORT Pulmonary Vascular and Advanced Lung Disease Ms Robin Fowler. Thoracic Society of Australia and New Zealand Best Physiotherapy Presentation TSANZ/ Mayo Healthcare 2009. Grants Please refer to the Grants Report for details of the grants that the Unit has been awarded. Positions Held Gabbay, E. Director, Advanced Lung Disease Program, Royal Perth Hospital. Gabbay, E. Head of Respiratory Medicine Department, Royal Perth Hospital. Gabbay, E. Founding and Current Chair, Heart and Lung Transplant Foundation of WA. Gabbay, E. Board of Directors, Jirruwan Health. Gabbay, E. Western Australian Government Committee to Improve Rate of Organ Donation. Gabbay, E. Scleroderma Australia Experts Research Advisory Committee. Gabbay, E. Co-Chair Workcover Occupational Diseases Board Western Australia. Gabbay, E. Immediate Past President Thoracic Society of Australia and NZ (WA). Gabbay, E. Australian Scleroderma Expert Advisory Group. Gabbay, E. National Examination Panel for FRACP clinical examinations. Gabbay, E. Member and Immediate Past Chair, Australian Lung Foundation Expert Group on Interstitial Lung Disease and Pulmonary Vascular Disease. Gabbay, E. Royal Perth Hospital Basic Physician Training Committee. Gabbay, E. Medicare Australia Clinical Experts Reference Group in Pulmonary Hypertension. Gabbay, E. Member of Advisory Board, Actelion Australia. Gabbay, E. Member of Advisory Board, CSL Biomedical. Gabbay, E. Member of Advisory Board, Pfizer Pharmaceuticals. Musk, M. Medical Director, Western Australian Lung Transplant Unit. Presentations and Chairmanship International Gabbay, E. Current Management Strategies in idiopathic PAH. 5th Asian PAH congress, Taipei, Taiwan, November 2009. Hill, K. Formulating an exercise program for patients with COPD. Canadian Respiratory Conference Toronto, Canada, March 2009. National and Local Gabbay, E. PAH complicating Scleroderma: Benefits of Screening. LIWA Lung and Biological Sciences Symposium. Perth, WA, March 2009. Gabbay, E. Pulmonary Hypertension Complicating Lung Disease. Cardiac Society of Australia and New Zealand, Annual Scientific Meeting. Sydney, NSW, August 2009. Gabbay, E. New Therapies for Pulmonary Arterial Hypertension. Australia New Zealand Society for Intensive Care, Annual Scientific Meeting. Perth, WA, October 2009. Hill, K. Inspiratory muscle training ; Measuring physical activity ; Inspiratory muscle training overview and as part of pulmonary rehabilitation. Australian Physiotherapy Association Annual Scientific Meeting. Sydney, NSW, October 2009. Hill, K. From the inspiratory muscles to physical activity rising star. Thoracic Society of Australia and New Zealand Western Australian Branch meeting. Mandurah, WA, October 2009. 38 2009 Annual Report Lung Institute of Western Australia Inc.

Referees Associate Professor Eli Gabbay is a referee for Internal Medicine Journal, Journal of Heart and Lung Transplantation, Advances in Pulmonary Hypertension (editorial board). Dr Kylie Hill is a referee for Chronic Respiratory Disease and Physiotherapy, Canada. Canadian Respiratory Health Professionals. Student Activities Ms Robin Fowler (PhD). Exercise testing in pulmonary arterial hypertension; improving diagnosis and establishing exercise training guidelines. Supervised by E Gabbay, S Jenkins, A Maiorana. Mr Geoff Strange (PhD). Barriers to timely diagnosis of Pulmonary Hypertension. Supervised by E Gabbay, A Keogh, S Stewart. Ms Louise Ganderton (PhD). Short term effect of exercise training on exercise capacity and quality of life in pulmonary arterial hypertension. Supervised by E Gabbay, S Jenkins, K Gain. Collaborations Australian Scleroderma Interest Group. Anne Keogh, St Vincents Hospital, NSW. Simon Stewart, Monash University, Melbourne VIC. Trevor Williams, The Alfred Hospital, VIC. Fiona Kermeen, The Prince Charles Hospital, QLD. Susanna Proudman, Royal Adelaide Hospital, SA. Lutz Beckert, Christchurch Hospital, New Zealand: Test-retest reliability of the Cambridge Pulmonary Hypertension Outcome Review (CAMPHOR). Physiotherapy The focus of this Unit is research into the role of exercise testing and exercise training in patients with asthma, bronchiectasis and COPD. Together with staff and students of the Pulmonary Vascular and Advanced Lung Diseases Unit, staff from this Unit are investigating the role of exercise testing and training in the diagnosis and management of PAH, and the assessment of quality of life in this population. Current research activities being undertaken by staff and students of the Unit include: Role of exercise training and airway clearance treatments in people with non-cystic fibrosis bronchiectasis, Strategies to optimise physical activity and well-being in people with COPD, Benefits of exercise training in people with PAH, and Muscle dysfunction following lung transplant. Staff Associate Professor Sue Jenkins PhD Head of Unit Mrs Nola Cecins MSc Pulmonary Rehabilitation Physiotherapist Dr Kylie Hill BSc (Physiotherapy) PhD Research Fellow Awards Mrs Nola Cecins, Associate Professor Sue Jenkins. Rotary Club of Mount Lawley in conjunction with Curtin University Allied Health Professional of the Year Award Certificate for Outstanding Achievement, 2009. Mrs Nola Cecins, Associate Professor Sue Jenkins. Thoracic Society of Australia and New Zealand (WA Branch) The Janine Panizza Award for Outstanding Contribution 2009. UNIT REPORT PHYSIOTHERAPY www.liwa.uwa.edu.au 39

UNIT REPORT PHYSIOTHERAPY Grants Please refer to the Grants Report for details of the grants that the Unit has been awarded. Positions Held Jenkins, S. Member, COPD Evaluation Committee, Australian Lung Foundation. Jenkins, S. Member, Pulmonary Rehabilitation Assembly Planning Committee, American Thoracic Society. Jenkins, S. Member, Research Advisory Committee, Sir Charles Gairdner Hospital. Jenkins, S. Member, Editorial Board of Physiotherapy. Jenkins, S. Member, Editorial Board of Chronic Respiratory Disease. Jenkins, S. Associate of the National Centre for the Advancement of Excellence in Cardiopulmonary Physiotherapy, University of Sydney. Jenkins, S. Associate of East-meets-West in Rehabilitation Sciences, The Hong Kong Polytechnic University. Cecins, N. Co-Convenor, Physiotherapy Special Interest Group, Thoracic Society of Australia and New Zealand. Cecins, N. Member, Respiratory Health Network Advisory Group, Department of Health, Health Networks Branch. Presentations and Chairmanship International Jenkins, S. Pulmonary rehabilitation in Australia. Nagasaki University Extension Lecture Nagasaki, Japan, July 2009. Jenkins, S. How to write a paper in English. Nagasaki University School of Health Sciences, Postgraduate Course. Nagasaki, Japan, July 2009. Jenkins, S. Physiotherapy in Australia. Kumamoto University of Health Sciences, Kumamoto, Japan, July 2009. National and local Jenkins, S. Pulmonary rehabilitation workshop update. Workshop convenor and presenter. Physiotherapy Department, Sir Charles Gairdner Hospital, Perth, WA, June 2009. Jenkins, S. Pulmonary rehabilitation in airways disease. LIWA Lung and Biological Science Symposium, Perth, WA, March 2009. Jenkins, S. Update in pulmonary rehabilitation. Cardiorespiratory Physiotherapy Australia, Level 1 Course, Perth, WA, August 2009. Jenkins, S. Publishing research. Allied Health Professions Research Education Program, Sir Charles Gairdner Hospital, Perth, WA, October 2009. Cecins, N. Pulmonary rehabilitation workshop update. Workshop convenor and presenter. Physiotherapy Department, Sir Charles Gairdner Hospital, Perth, WA, June 2009. Cecins, N. Pulmonary rehabilitation workshop. Convenor and presenter. WA Country Health Service South West, Bunbury, WA, March 2009. Cecins, N. Managing breathlessness and airway clearance. Invited speaker for LISA (now LIFE) SCGH patient support group, Perth, WA, March 2009. Referees Associate Professor Sue Jenkins has acted as a referee for the Chronic Respiratory Disease, Chest, the Australian Journal of Physiotherapy and for NHMRC (Australia). Student Activities Sian Turner (PhD). Burden of disease and benefits of exercise in in asthma. Supervised by S Jenkins, P Eastwood, PJ Thompson, A Cook. Ms Robin Fowler (PhD). Exercise testing in PAH; improving diagnosis and establishing exercise training guidelines. Supervised by E Gabbay, A Maiorana, S Jenkins. 40 2009 Annual Report Lung Institute of Western Australia Inc.

Ms Louise Ganderton (MSc). Short term effects of exercise training on exercise capacity and quality of life in patients with pulmonary arterial hypertension. Supervised by E Gabbay, S Jenkins, K Gains. Collaborations International Professor Hideaki Senjyu. Department of Physical Therapy, School of Health Sciences, Nagasaki University, Nagasaki, Japan. Pulmonary rehabilitation in chronic lung disease. Professor Alice Jones. Hong Kong Polytechnic University, Hong Kong. Pulmonary rehabilitation and professional sexual boundaries. Professor Roger Goldstein. University of Toronto, West Park Healthcare Centre, Toronto, Canada. Prevalence of COPD in adults with known risk factors and physiological responses to field-based walking tests in COPD. Associate Professor Dina Brooks. University of Toronto, West Park Healthcare Centre, Toronto, Canada. Physiological responses to field-based walking tests in COPD. National Associate Professor Jennifer Alison. Professor Christine Jenkins, Dr Zoe McKeough, Faculty of Health Sciences, University of Sydney. The benefits of walking training in COPD. Associate Professor Anne Holland and Dr Annemarie Lee. Physiotherapy Department, Alfred Hospital. Benefits of pulmonary rehabilitation in non-cystic fibrosis bronchiectasis. Local Associate Professor Peter Eastwood and Dr David Hillman. Pulmonary Physiology, Sir Charles Gairdner Hospital. Mechanisms of exercise limitation in COPD; benefits of walking training in COPD; Optimising physical activity in COPD. Professor Jane Davidson. School of Music, UWA, Investigating the holistic health benefits of group singing for the elderly. Infectious Diseases The infectious diseases group had another productive year in 2009. A PhD student, Ms Cordelia Kee, has continued working with Professor Waterer and scientists in the Department of Microbiology and Infectious Diseases at Royal Perth Hospital (Mr Ian Kay, Mr Todd Pryce, Mr Silvano Palladino and Dr Ronan Murray) on a new diagnostic test for the main cause of pneumonia, Streptococcus pneumoniae. Two recent publications in Chest have outlined how this new assay is a significant advance over existing assays. The paper written in collaboration with Professor Jordi Rello s research group in Tarragona, Spain, was selected as one of the infectious diseases papers of the year at the American College of Chest Physicians meeting in November and a number of research groups at the University of Texas (San Antonio), Louisiana State University (New Orleans) and Northwestern University (Chicago) are now collaborating with us on further projects exploring the potential of this new assay. UNIT REPORT INFECTIOUS DISEASES www.liwa.uwa.edu.au 41

UNIT REPORT INFECTIOUS DISEASES Dr Suzanna Temple and Professor Waterer have continued working on the development of a new drug to treat severe sepsis aided by a grant from the Medical Research Foundation at Royal Perth Hospital and this has now progressed to animal studies. Professor Waterer spent six months on sabbatical at Northwestern University in Chicago as well as being a visiting Professor at Yale, the University of Connecticut, the University of Utah, the University of Texas (San Antonio) and Louisiana State University (New Orleans). A number of projects have arisen from these visits and will hopefully continue to add to the collaborative work we have done including publications with both Dr Marcos Restrepo and Associate Professor Eric Mortensen at the University of Texas (San Antonio) and Professor Rello s group in Spain. Professor Waterer was also appointed to the Editorial Board of the leading Respiratory medical journal, the American Journal of Respiratory and Critical Care Medicine. Staff Professor Grant Waterer MBBS PhD MBA Head of Unit Dr Suzanna Temple BSc (Hons) PhD MBA Senior Scientist Grants Please refer to the Grants Report for details of the grants that the Unit has been awarded. Positions Held Waterer, G. Royal Perth Hospital Appointments Committee. Waterer, G. Royal Perth Hospital A:H1N1 Advisory Group. Waterer, G. Australian Lung Foundation Respiratory Infectious Diseases Advisory Group. Waterer, G. Thoracic Society of Australia and New Zealand A:H1N1 Taskforce. Waterer, G. American Thoracic Society Bronchiectasis Statement. Temple, S. Member, Australian Society of Medical Research. Temple, S. Member, Australasian Society of Immunology. Temple, S. Member, Human Genetics Society of Australasia. Presentations and Chairmanship Waterer, G. The influence of inflammation on the outcome of pneumonia. American Thoracic Society Annual Scientific Meeting, San Diego, USA, 2009. Waterer, G. Time to antibiotics as an outcome measure, in CAP. American Thoracic Society Annual Scientific Meeting, San Diego, USA, 2009. Waterer, G. Genetics susceptibility to pulmonary infections. American College of Chest Physicians, San Diego, USA, 2009. Waterer, G. Long term complications from pneumonia. Visiting Professor, University of Utah (Salt Lake City), September 2009. Waterer, G. Pneumococcal pneumonia. Visiting Professor, University of Utah (Salt Lake City), September 2009. Waterer, G. Genetic influences on pneumonia and sepsis. Visiting Professor, University of Utah (Salt Lake City), September 2009. Referees Professor Grant Waterer has acted as referee for American Journal of Respiratory and Critical Care Medicine, Chest, Thorax, European Respiratory Journal, Critical Care Medicine, Intensive Care Medicine, Medical Journal of Australia, Journal of Infectious Diseases. Dr Suzanna Temple has acted as referee for Chest, Genes and Immunity, Human Immunology, Current Pharmacogenomics, Tissue Antigens, Clinical Experimental Immunology, Journal of Translational Medicine and Respirology. 42 2009 Annual Report Lung Institute of Western Australia Inc.

Student activities Ms Cordelia Kee (PhD). Real-time quantitative PCR as a diagnostic and prognostic tool in patients with community-acquired pneumonia. Supervised by G Waterer, K Croft, I Kay and T Pryce. Collaborations Professor Jordi Rello. Joan XXIII University, Tarragona, Spain. Professor Richard Wunderink. Northwestern University, Chicago, USA. Associate Professor Eric Mortensen. University of Texas (San Antonio), USA. Professor Carlos Luna. University of Buenos Aires. Professor Patricia Price. School of Laboratory Medicine, University of Western Australia. Cardiothoracic Surgery The Cardiothoracic Surgery Unit was established in June 2009, with the aim of promoting research collaboration between the Department of Cardiothoracic Surgery at Sir Charles Gairdner Hospital and LIWA clinicians and scientists working in allied areas of lung research. The initial focus of the Unit has been a research project funded by an NHMRC grant to Professor Igor Konstantinov. This project is investigating the protective effect of Remote Ischaemic Preconditioning (RIPC) against cardiac and lung injury in patients undergoing Coronary Artery Bypass Graft (CABG) surgery. Patients undergoing CABG with standard heart arrest and cardiopulmonary bypass develop tissue injury due to myocardial ischaemia and a systemic inflammatory response. It is thought that repeated application of brief periods of ischaemia (3 x 5 min) to the upper arm (RIPC), either 24 hours or immediately before CABG surgery may protect against subsequent ischaemia-reperfusion injury of cardiac and lung tissue following surgery, and that the kallikrein-kinin system may play an important role in this protective effect. In the first part of this project, we showed that in healthy volunteers application of RIPC decreased the expression of kinin receptors on neutrophils. In the second part of the study RIPC will be applied in patients immediately before they undergo CABG, and blood samples will be collected over a 48 hour period to assess kinin receptor expression on neutrophils, as well as a number of biomarkers of cardiac and lung injury. We aim to recruit 15 patients who will receive RIPC and 15 control patients who will not receive RIPC prior to surgery, and to compare the results between these two groups of patients. Staff Mr Mark Newman DS FRACS Head of Unit; Head Department of Cardiothoracic Surgery, Sir Charles Gairdner Hospital, Perth, WA Professor Igor Konstantinov MD PhD Clinical Professor of Surgery, Consultant Cardiac Surgeon, Royal Children s Hospital, Melbourne, VIC Dr Pankaj Saxena MCh DNB Cardiothoracic Surgeon, Royal Perth Hospital, Perth, WA Mr Jurgen Passage FRACS Cardiothoracic Surgeon, Sir Charles Gairdner Hospital, Perth, WA Mr Lucas Sanders FRACS Cardiothoracic Surgeon, Sir Charles Gairdner Hospital, Perth, WA UNIT REPORT CARDIOTHORACIC SURGERY www.liwa.uwa.edu.au 43

UNIT REPORT CYSTIC FIBROSIS / BRONCHIECTASIS Dr Neil Misso BSc PhD Senior Scientist, LIWA Dr Shashi Aggarwal BSc MSc PhD Research Officer Ms Odette Shaw BSc (Hons) Research Assistant Winthrop Professor Philip Thompson MBBS FRACP MRACMA FCCP Grants Please refer to the Grants Report for details of the grants that the Unit has been awarded. Cystic Fibrosis / Bronchiectasis The Cystic Fibrosis (CF) and Bronchiectasis Unit was established in spring 2009. The aim of the group is to conduct clinical and laboratory research into these conditions. Current clinical trials focus on inhaled antibiotic therapy and a cystic fibrosis transmembrane conductance regulator (CFTR) potentiator (VX-770). VX-770 is a possible therapeutic strategy to treat CF. By increasing the frequency of CFTR chloride channel opening VX-770 potentially allows for maintenance of airway hydration, which may prevent the thick mucus, airway inflammation and lung disease associated with this condition. The current study focuses on CF subjects with the G551D mutation in at least one CFTR allele. Studies of the use of inhaled ciprofloxacin in both CF and Bronchiectasis are ongoing. Our Unit is dedicated to the search for new improved treatments for CF and Bronchiectasis. Staff Dr Siobhain Mulrennan MBChB MRCP MD Head of Unit; CF and Respiratory Consultant Dr Gerard Ryan MBBS FRACP CF and Respiratory Consultant Ms Sue Morey OAM FRCNA CF Nurse Consultant Mr Jamie Wood BSc (Physiotherapy) Senior Respiratory Physiotherapist Mrs Michelle Davies RN Clinical Trials Manager Ms Charlotte Hall RN Clinical Trials Coordinator Dr Grant Waterer MBBS PhD FRACP MBA Respiratory Consultant Winthrop Professor Philip Thompson MBBS FRACP FCCP MRACMA Positions Held Mulrennan, S. Member CF Ball Committee, Cystic Fibrosis WA. Morey, S. Vice President, Board of Management, Westcare Inc. Morey, S. Member, Board of Management, Cystic Fibrosis WA. Morey, S. Member, Board of Management, Australian Council on Smoking and Health (ACOSH). Morey, S. Member, Board of Management, Cystic Fibrosis Australia. Presentations and Chairmanship Mulrennan, S. The use of cgms in the diagnosis and management of CFRD. Cystic Fibrosis Conference, Brisbane, August 2009. 44 2009 Annual Report Lung Institute of Western Australia Inc.

unit report Corporate Services Respirology The Respirology Unit houses the editorial office of the journal Respirology, the official journal of the Asian Pacific Society of Respirology. Respirology is a journal of international standing, publishing peer-reviewed articles of scientific excellence in clinical and experimental respiratory biology and disease and its related fields of research including thoracic surgery, internal medicine, immunology, intensive and critical care, epidemiology, cell and molecular biology, pathology, pharmacology and physiology. The Unit publishes eight issues of the journal and receives about 800 manuscripts a year. The editorial office consists of a manager, an assistant manager, an administrative editor and two editorial assistants (part-time) and works with a team of an editor-in-chief, an editor-in-chief elect, four senior editors, 15 associate editors, and 30 editorial board members from across the globe. Respirology has an impact factor of 1.849 and is currently ranked 24 / 40 of its category of Respiratory System Journals. Its impact factor has almost doubled since its debut impact factor four years ago. The editorial office manages the daily operation of the journal including checking new manuscripts for journal compliance and overseeing the smooth running of their peer-review process, managing the publication of invited reviews, ensuring the timely and accurate publication of the accepted manuscripts, communication with the editors, society executives, authors, reviewers and editorial board members to cite a few. Staff Dr Lieve Bultynck PhD Manager The editorial office also provides full administrative and secretarial support to the editor-in-chief. Dr Christel Norman PhD Assistant Manager Dr Joyanne Kelly PhD Administrative Editor Dr Naomi Alexander PhD Administrative Editor Dr Neil Misso PhD Editorial Assistant Dr Margaret Stevens PhD Editorial Assistant Winthrop Professor YC Gary Lee MBChB PhD FCCP FRACP Editor-in-Chief UNIT REPORT RESPIROLOGY www.liwa.uwa.edu.au 45

UNIT REPORT COMMUNITY SUPPORT GROUP (LIFE) Community Support Group (LIFE) LIFE became the community support arm of LIWA from 1 July 2009. Formerly known as LISA (Lung Impaired Support Association) which began in 1992 as the first respiratory self help / support group in Australia, LIFE now stands for Lung Information and Friendship for Everyone and continues to promote self-help. LIFE aims to provide support and information to people with chronic lung disease and their carers, through fellowship and information sharing. LIFE is run entirely by, and for, people with chronic lung conditions, their carers, families and supporters. The group provides monthly gatherings, a speaker program, a newsletter and social events including day trips. LIFE increases community and health professional awareness of the existence and benefits of support groups for people with chronic lung disease. Staff Volunteer co-ordinators: Mrs Edna Brown Dr Jenni Ibrahim Positions Held Ibrahim, J. Health Consumer Representative, Respiratory Health Network Executive and Advisory groups, Department of Health WA. Ibrahim, J. Health Consumer Representative, Data Linkage Advisory Board, Department of Health WA. Ibrahim, J. Health Consumer Representative, Cross Jurisdictional Data Linkage Steering Committee, Department of Health WA and Commonwealth Department of Health and Ageing. Collaborations LIFE remains an affiliate of LungNet and liaises with the Australian Lung Foundation regarding respiratory support and education matters, including the annual WA LungNet seminar for people with chronic lung disease. Regular meetings and contact with leaders of other respiratory support groups in WA for mutual support and exchange of ideas. LIFE members volunteer as model patients for UWA Medical School and as subjects in respiratory research, including LIWA s Clinical Trials Unit. LIFE publicises LIWA s Clinical Trials Unit through its widely distributed newsletter, Breath of LIFE. 46 2009 Annual Report Lung Institute of Western Australia Inc.

Administration / Finance Staff Ms Tineke Van der Eecken Executive Officer Ms Sharon Squires-Hansen Public Relations Manager Ms Robyn Tandon Public Relations Officer Mr Bi Lam Finance Officer Ms Lee Matthews Administration Officer (to March 2009) Ms Karen Coveney Administration and HR Officer (fr. April 2009) Ms Sarah Cermak (fr. December 2009) Ms Pam McManus Administration Officer Ms Sherry Lea Administration Officer (fr. December 2009) The administration team at LIWA aims to support its Board of Directors and the various research units in such a way that each can operate to their full potential. Our roles include: Management of the finance services including financial management, budgeting, bookkeeping, investment management, project accounting, financial reporting, purchasing and governance / compliance services. Provision of corporate services including company secretariat, corporate governance, reception, administration and executive support services. Human resource management including management of staff recruitment and selection, human resource policy, performance management, payroll, and student coordination. Information technology services including the provision of computing services, network administration and IT purchasing services. Developing contracts, policies and procedures. Facilities management and asset management. Management of LIWA grants and awards, and Executive support to regular meetings such as the Board meetings, management committee meetings and breakfast research meetings. Highlights in 2009 included the development of a new performance management system and other HR activities, reviewing and improving the IT and computer network, the development of improved financial systems and the administrative duties associated with major events. Although the team s resources were stretched to capacity with the extraordinary 10th Anniversary celebrations, the Institute is proud to close the year with considerable profit. UNIT REPORT ADMINISTRATION / FINANCE www.liwa.uwa.edu.au 47

UNIT REPORT PUBLIC RELATIONS Public Relations In LIWA s 10th Anniversary year, the public relations team stepped up its efforts to promote the many activities of the Institute. Sharon Squires-Hansen, as public relations manager, managed and coordinated media and public relation activities until September 2009. Robyn Tandon was initially tasked with the responsibility of developing LIWA s membership, and later became public relations officer. As always, the research being conducted at LIWA was championed locally, nationally and internationally. The Lung and Biological Science Symposium was widely marketed and received significant media attention with a four page lift out in the West Australian newspaper. The PR team promoted LIWA s commitment to respiratory health in the community by coordinating the inaugural Breathe Easy Week. With a new PR team and many events taking place throughout the year it was a busy and very productive time. We look forward to maintaining the momentum created and building on our activities in 2010. Events PR is responsible for planning, marketing and administering a great number of events. In 2009, this included regular events such as the Medical Research Seminar Series, visiting speakers events, a student promotion evening and a Christmas lunch for LIWA members, as well as the Lung and Biological Sciences Symposium, the launch of LIFE, a Wine Soiree and last but not least Breathe Easy Week. Details of the events managed by the PR team are outlined in previous sections of this report. Media coverage A total of 27 Media releases were produced by the PR team throughout 2009. This resulted in LIWA featuring widely across many forms of media, which include the following: A four page feature in the West Australian, 11 March 2009, A feature story on Channel 9 s A Current Affair, 3 November 2009, Multiple radio interviews throughout the year featuring LIWA experts commenting on respiratory topics and events; and Extensive newspaper exposure was received throughout 2009, in particular a lot of publicity was received in relation to Breathe Easy Week and the launch of LIFE (community support group). Publications The PR team is responsible for the planning, design, composition and printing of LIWA s regular publications. This included the 2008 Annual Report, four editions of LIWA s newsletter A Breathe of Fresh Air and monthly editions of LIWA s internal newsletter Puff. Website LIWA s website is an important feature of our communication, particularly given our international standing in the research community. In addition to regular updates of the site, a new on-line donation system was established to facilitate fundraising efforts. Photo: ABC presenter Bernadette Young tests her lungs on-air with Professor Thompson 48 2009 Annual Report Lung Institute of Western Australia Inc.

partnerships & alliances CRC for Asthma and Airways The CRC for Asthma and Airways commenced operation in July 2005, as a joint venture under the Commonwealth Government Cooperative Research Centre Program between the University of Western Australia, The Garvan Institute, Woolcock Institute, Universities of Sydney, Monash and Newcastle, WA Departments of Environment and Health, GlaxoSmithKline, Pharmaxis, NSW Health and Bird Healthcare. As with the CRC for Asthma, LIWA is actively associated with the current CRC through its UWA Centre for Asthma, Allergy and Respiratory Research and via its contribution of funds ($37,500 per annum) and staff for the work that is being undertaken. There have been two nodes, one of which is managed by the School of Population Health and focuses on the role of air quality and lung disease. We manage the node investigating the role of genetics in asthma and, as such, is trying to identify genetic abnormalities involved and ultimately to better treatments. Curtin University The Institute signed an Affiliation Agreement with Curtin University in June 2006, allowing the Institute to offer PhD Scholarships to Curtin students and strengthen the good relationship between the two organisations in other ways. Cystic Fibrosis WA The Institute signed a Memorandum of Understanding with CFWA in 2007. As mentioned earlier in this report, the overlap in our common goals and the goodwill between the two organisations helps provide bilateral support and success. Cystic Fibrosis continues to be a major area of respiratory disease. Sir Charles Gairdner Hospital The Institute is very fortunate to have the support of senior management from Sir Charles Gairdner Hospital. The Hospital has generously allowed the Institute to utilise and develop space on the campus for its operations. The goodwill which has existed between the Institute and the Hospital throughout the Institute s development is critical and much appreciated. The University of Western Australia The Institute enjoys a strong relationship with UWA, initially through a formal Affiliation Agreement, then with the establishment of the Centre for Asthma Allergy and Respiratory Research within the School of Medicine and Pharmacology in January 2005, which was renewed in 2009. All our senior staff hold honorary or adjunct appointments with the Centre, giving them ACTIVE LIWA PARTNERSHIPS & ALLIANCES www.liwa.uwa.edu.au 49

ACTIVE LIWA PARTNERSHIPS & ALLIANCES comparable status with UWA salaried staff regarding access to UWA facilities. The Centre administers the WA Node of the CRC for Asthma and Airways and works with UWA to ensure that our respective obligations to the CRC are fulfilled. The West Australian Institute of Medical Research A Memorandum of Understanding between LIWA and WAIMR was signed in October 2003 promoting cooperation and mutual support between the two organisations in the areas of coordination of funding, and the promotion of education and research activities. The LIWA Genetics laboratories are located within WAIMR. A highlight of the cooperation between WAIMR and LIWA has been joint education initiatives, run by both organisations and the CRC for Asthma and Airways. Westcare The alliance with Westcare Industries, while still fairly young, is growing stronger. This alliance enhances the endeavours of both organisations to ensure that tuberculosis and other lung infections are well managed and that breathlessness receives greater recognition as a major disability and receives appropriate support. Donations and Sponsors LIWA appreciates all donations made to respiratory research, whatever the size. In 2009 we were pleased to receive a significant number of donations, including an anonymous donation of $10,000 for the 10th Anniversary. We are also grateful for the generous support of our sponsors, including: AstraZeneca, for their sponsorship of the Lung and Biological Sciences Symposium; BHP Billiton, for their sponsorship of Breathe Easy Week ; Abbott Solutions and Westcare Inc. for their sponsorship of media publications; and Strathearn Insurance Brokers for their sponsorship of Breathe Easy Week promotion. WAIMR 50 2009 Annual Report Lung Institute of Western Australia Inc.

publications report Journal Articles Aggarwal S, Moodley YP, Thompson PJ, Misso NL. Prostaglandin E2 and cysteinyl leukotriene concentrations in induced sputum: association with asthma severity and eosinophilic inflammation. Clinical and Experimental Allergy 2009, 4 Nov (Epub ahead of print). Baltic S, Thompson P, Fogel-Petrovic M. -synuclein affects dendritic cell differentiation. Respirology 2009 Apr; 14(Suppl.1):A48. Beauchamp K, Dolmage TE, Nonoyama M, Goldstein RS, Hill K, Mathur S, Brooks D. Interval versus continuous training in individuals with COPD a systematic review. Thorax 2009, Dec 8 (Epub ahead of print). Beauchamp MK, Hill K, Goldstein RS, Janaudis-Ferreira T, Brooks D. Impairments in balance discriminate fallers from non-fallers in COPD. Respiratory Medicine 2009 Dec; 103(12):1885-1891. Bertram CM, Misso NL, Fogel-Petrovic M, Figueroa CD, Foster PS, Thompson PJ, Bhoola KD. Expression of kinin receptors on eosinophils: comparison of asthmatic patients and healthy subjects. Journal of Leukocyte Biology. 2009 Mar; 85(3):544-552. Bielsa S, Davies HE, Davies RJO, Taylor A, Lee YCG. Reproducibility and reliability of pleural fluid cytokine measurements. European Respiratory Journal 2009; 34:1001-1003. Campbell L, Bunston R, Colangelo S, Kim D, Nargi J, Hill K, Brooks D. The provision of weekend physical therapy services in tertiary care hospitals in Canada. Physiotherapy Canada (in press). Carr SJ, Hill K, Brooks D, Goldstein RS. Pulmonary rehabilitation after acute exacerbation of chronic obstructive pulmonary disease in patients who previously completed a pulmonary rehabilitation program. Journal of Cardiopulmonary Rehabilitation and Prevention 2009 Sept-Oct; 29(5);318-24. Cassim B, Shaw OM, Mazur M, Misso NL, Naran A, Langlands DR, Thompson PJ, Bhoola KD. Kallikreins, kininogens and kinin receptors on circulating and synovial fluid neutrophils:role in kinin generation in rheumatoid arthritis. Rheumatology 2009; 48:490-496. Davies HE, Sadler RS, Bielsa S, Maskell NA, Rahman NM, Davies RJO, Ferry BL, Lee YCG. The clinical applicability of pleural fluid mesothelin measurements. American Journal of Respiratory and Critical Care Medicine 2009; 180:437-44. de Voss AJ, Cook A, Devine B, Thompson PJ, Weinstein P. Effect of protective filters on fire fighter respiratory health field validation during prescribed burns. American Journal of Industrial Medicine. 2009; 52:76-87. Ehrenfeld P, Matus CE, Pavicic F, Toledo C, Nualart F, Gonzalez CB, Burgos RA, Bhoola KD, Figueroa CD. Kinin B1 receptor activation turns on exocytosis of matrix metalloprotease-9 and myeloperoxidase in human neutrophils: involvement of mitogen-activated protein kinase family. Journal of Leukocyte Biology 2009 Nov; 86(5):1179-1189. Fogel-Petrovic M, Baltic S, Thompson P. Dendritic cells (DC) susceptibility to synyclein-induced apoptosis depends on DC maturation status. Respirology 2009 Apr; 14 (Suppl.1); A47. Gudbjartsson DF, Bjornsdottir US, Halapi E, Helgadottir A, Sulem P, Jonsdottir GM, Thorleifsson G, Helgadottir H, Steinthorsdottir V, Stefansson H, Williams C, Koppelman GH, Heinzmann A, Krueger M, Boezen HM, Wheatly A, Altmuller J, Shin HD, Uh S, Cheong HS, Jonsdottir B, Gislason D, Park C, Rasmussen LM, Porsbjerg C, Hansen JW, Backer V, Werge T, Janson C, Jönsson U, Ng MCY, Chan J, So WY, Ma R, Shah SH, Granger CB, Quyyumi AA, Levey AI, Vaccarino V, Reilly MP, Rader DJ, Williams MJA, van Rij AAM, Jones GT, Trabetti E, Malerba G, Pignatti PF, Eyjolfsson GI, Thorgeirsson G, Deichmannb K, Thompson PJ, Wjst M, Hall IP, Postma DS, Gislason T, Gulcher J, Kong A, Jonsdottir I, Thorsteinsdottir U, Stefansson K. Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction. Nature Genetics 2009; 41:342-347. Harth L, Stuart J, Montgomery C, Pintier K, Czyzo S, Hill K, Goldstein R, Brooks D. Physical therapy practice patterns in acute exacerbations of chronic obstructive pulmonary disease. Canadian Respiratory Journal 2009 May-Jun; 16(3):86-92. Higton A, Whale C, Musk M, Gabbay E. Beware the pregnant woman with breathlessness. Thorax 2009 Jul; 64(7):580,586. ACTIVE LIWA PUBLICATIONS REPORT www.liwa.uwa.edu.au 51

ACTIVE LIWA PUBLICATIONS REPORT Hill K, Brooks D. A description of weekend physiotherapy services in three tertiary hospitals in the Greater Toronto Area. Physiotherapy Canada (in press). Hill K, Patman S, Brooks D. Effect of airway clearance techniques in patients experiencing an acute exacerbation of chronic obstructive pulmonary disease: a systematic review. Chronic Respiratory Disease 2009, 9 Oct (Epub ahead of print). Hodge S, Holmes M, Banerjee B, Musk M, Kicic A, Waterer G, Reynolds PN, Hodge G, Chambers DC. Post-transplant bronchiolitis obliterans syndrome is associated with bronchial epithelial to mesenchymal transition. American Journal of Transplantation 2009 Apr; 9(4):727-33. Janaudis-Ferreira T, Hill K, Goldstein R, Wadell K, Brooks D. Arm training in patients with COPD: a systematic review. Journal of Cardiopulmonary Rehabilitation and Prevention 2009 Sept-Oct; 29(5):277-83. Jenkins S, Cecins N, Camarri B, Williams C, Thompson P, Eastwood P. Regression equations to predict six minute walk distance in middle aged and elderly adults. Physiotherapy Theory and Practice 2009; 25(7):516-522. Keogh A, McNeil K, Williams TJ, Gabbay E, Proudman S, Weintraub RG, Wlodarczyk J, Dalton B. The Bosentan Patient Registry: long-term survival in pulmonary arterial hypertension. Internal Medicine Journal 2009, 3 Dec (Epub ahead of print). Konstantinov IE, Saxena P, Barrett T, Jenkins G. Resection and reconstruction of the roof of the coronary sinus for an unusually attached left atrial myxoma. Journal of Thoracic Cardiovascular Surgery 2009 Apr; 137(4):1032-4. Konstantinov IE, Saxena P, d Udekem Y, Brizard CP. Isolated subclavian artery: anatomical and surgical considerations. The Annals of Thoracic Surgery 2009 Nov; 88(5):1685-7. Konstantinov IE, Saxena P, Ling S, Barrett T. Repair of acute postinfarction atrioventricular dehiscence in patient with posterior left ventricular aneurysm. The Journal of Thoracic and Cardiovascular Surgery 2009 Jan; 137(1):247-9. Konstantinov IE, Saxena P, Shehatha J. Coronary stent disease: when will enough be enough? The Journal of Thoracic and Cardiovascular Surgery 2009 Apr; 137(4):1020-1. Konstantinov IE, Saxena P, Shehatha J. Spontaneous multivessel coronary artery dissection: surgical management in a postmenopausal woman. Texas Heart Institute Journal 2009; 36(4):360-1. Konstantinov IE, Saxena P, Wood DJ. Stabilisation of chronic flail chest: a novel approach of surgical fixation and osteogenesis. Thorax 2009; 64(3):265-6. Konstantinov IE, Saxena P. Independent lung ventilation in the postoperative management of large bronchopleural fistula. The Journal of Thoracic and Cardiovascular Surgery 2009, 17 Jan (Epub ahead of print). Konstantinov IE, Saxena P. Sternal stabilization by interlocking wires: an alternative simple technique for high-risk patients. Journal of Cardiac Surgery 2009 Sep-Oct; 24(5): 510-1. Konstantinov IE. At the cutting edge of the impossible: a tribute to Vladimir P. Demikhov. Texas Heart Institute Journal 2009; 36(5):453-8. Konstantinov IE. Taussig-Bing anomaly: from original description to the current era. Texas Heart Institute Journal 2009; 36(6):580-5. Kotsimbos T, Waterer G, Jenkins C, Kelly PM, Cheng A, Hancox RJ, Holmes M, Wood-Baker R, Bowler S, Irving L, Thompson PJ. H1N1 Influenza 09: Australia and New Zealand s Winter of Discontent. American Journal of Critical Care and Respiratory Medicine 2009 (In Press). Lee AL, Cecins N, Hill CJ, Holland AE, Rautela L, Stirling RG, Thompson PJ, McDonald CF, Jenkins S. The effects of pulmonary rehabilitation in patients with non-cystic fibrosis bronchiectasis: protocol for a randomized controlled trial. BMC Pulmonary Medicine 2010 (In Press). Lisboa T, Blot S, Waterer GW, Canalis E, De Mendoza D, Rodriguez A, Rello J. Radiological progression of pulmonary infiltrates predicts a worse prognosis in severe community-acquired pneumonia than bacteremia. Chest 2009; 135(1):165-172. Mangat P, Conron M, Gabbay E, Proudman SM on behalf of the Pulmonary Interstitial Vascular Organisational Taskforce (PIVOT). Scleroderma Lung Disease; Variation in Screening, Diagnosis and Treatment practices between rheumatologists and respiratory physicians. Internal Medicine Journal 2009, 21 May (Epub ahead of print). Misso NL, Aggarwal S, Thompson PJ, Vally H. Increases in urinary 9alpha,11beta-prostaglandin F(2) indicate mast cell activation in wine-induced asthma. International Archives of Allergy and Immunololgy. 2009; 149: 127-132. Moosa D, Blouin M, Hill K, Goldstein R. Workshops to disseminate the Canadian Thoracic Society guidelines for chronic obstructive pulmonary disease to health care professionals in Ontario: impact on knowledge, perceived health care practices and participant satisfaction. Canadian Respiratory Journal 2009 May-Jun; 16(3):81-5. 52 2009 Annual Report Lung Institute of Western Australia Inc.

Mulrennan SA, Helm J, Thomas RB, Dodd M, Jones A, Webb K. Aminoglycoside ototoxicity susceptibility in cystic fibrosis. Thorax 2009 Mar; 64(3):271-2. Murray CP, Wong PM, Louw J, Waterer GW. Western Australian cigarette smokers have fewer small lung nodules than North Americans on CT screening for lung cancer. Journal of Medical Imaging and Radiation Oncology 2009 Aug; 53(4): 339-44. Phung S, Strange G, Leong J, Dalton B, Roddy J, Deague J, Playford D, Musk M, Gabbay E. Prevalence of pulmonary arterial hypertension in a scleroderma population: benefits of a screening program. Internal Medicine Journal 2009; 39:682-691. Rello J, Lisboa T, Lujan M, Gallego M, Kee C, Kay I, Lopez D, Waterer GW. Severity of Pneumococcal Pneumonia Associated With Genomic Bacterial Load. Chest 2009;136 832-840. Restrepo MI, Mortensen EM, Waterer GW, Wunderink RG, Anzueto A. Impact of macrolide therapy on mortality for patients with severe sepsis due to pneumonia. European Respiratory Journal 2009 Jan; 33(1):153-9. Sanders LH, Newman MA. Antegrade and Retrograde Stanford Type A Intimal Intussusception. The Annals of Thoracic Surgery 2009 Jun; 87(6):2003. Sanders LH, Soliman HM, van Straten AH. Management of right ventricular injury after localization of the left anterior descending coronary artery. The Annals of Thoracic Surgery 2009 Aug; 88(2):665-7. Sanders LH, Anderson BJ, Shehatha J, Clarson M, Mundy JA. Aortic valve replacement and coronary artery bypass grafting in a rare case of congenital hypofibrinogenemia. The Annals of Thoracic Surgery 2009 Oct; 88(4):1329-31. Sanders LH, Chen W, Schonberger JPAM, Shehatha J, Newman MA. Use of the Seldinger type movement over a J-shaped stylet for left ventricular vent insertion. The Annals of Thoracic Surgery 2009 Dec; 88(6):2050-1. Saxena P, Bala A, Campbell K, Meloni B, d Udekem Y, Konstantinov IE. Does remote ischemic preconditioning prevent delayed hippocampal neuronal death following transient global cerebral ischemia in rats? Perfusion 2009 May; 24(3): 207-11. Saxena P, Konstantinov IE, Downie S, Newman MA. Quadricuspid aortic valve: a rare clinical entity. Heart Lung and Circulation 2009 Feb; 18(1):50-1. Saxena P, Konstantinov IE. Bhagavant Kalke and his pioneering work on the bi-leaflet heart valve prosthesis. The Annals of Thoracic Surgery 2009 Jul; 88(1):344-7. Saxena P, Newman MA, Shehatha JS, Redington AN, Konstantinov IE. Remote ischemic conditioning: evolution of the concept, mechanisms, and clinical application. Journal of Cardiac Surgery 2009, Jun 22 (Epub ahead of print). Saxena P, Shaw OM, Misso NL, Naran A, Shehatha J, Newman MAJ, d Udekem Y, Thompson PJ, Konstantinov IE. Remote ischemic preconditioning stimulus decreases the expression of kinin receptors in human neutrophils. The Journal of Surgical Research 2009, 30 Nov. (Epub ahead of print). Saxena P, Shehatha J, Boyt A, Newman M, Konstantinov IE. Role of extracorporeal circulation in the management of accidental deep hypothermia. Heart Lung and Circulation 2009 Dec; 18(6):416-8. Saxena P, Shehatha J, Downie S, Newman MA, Konstantinov IE. Translocation of prosthetic aortic valve in advanced prosthetic valve endocarditis. Texas Heart Institute Journal 2009; 36(6):604-6. Saxena P, Sivapathasingam V, Vicaretti M, Costa RJ. Thoracic aortic aneurysm in the presence of mediastinal and retroperitoneal fibrosis. Heart Lung and Circulation 2009 Aug; 18(4):294-5. Saxena P, Thompson PJ, Konstantinov IE. Kallikrein-Kinin system: a surgical perspective in post-apoprotinin era. Journal of Surgical Research (In Press). Scotton CJ, Krupiczojc MA, Koenigshoff M, Mercer PF, Lee YCG, Kaminski N, Morser J, Post JM, Maher T, Nicholson AG, Moffatt JD, Laurent GJ, Derian CK, Eickelberg O, Chambers RC. Local extrahepatic upregulation of coagulation Factor X contributes to the fibrotic response to lung injury. Journal of Clinical Investigation 2009; 119:2550-2563. Shehatha J, Alward M, Saxena P, Konstantinov IE. Surgical management of cardiac hydatidosis. Texas Heart Institute Journal 2009; 36(1):72-3. Shehatha J, Saxena P, Clarke B, Dunning J, Konstantinov IE. Surgical management of extensive pulmonary artery sarcoma. The Annals of Thoracic Surgery 2009; 87(4):1269-71. Temple SE, Cheong KY, Price P, Waterer GW. Pathogenic bacteria and TNF do not induce production of macrophage migration inhibitory factor (MIF) by human monocytes. Cytokine 2009 Jun; 46(3):316-8. Valente FP, Tan CRT, Temple SE, Phipps M, Witt CS, Kaur G, Gut I, McGinn S, Allcock RJ, Chew CSN, Price P. The evolution and diversity of TNF block haplotypes in European, Asian and Australian Aboriginal populations. Genes and Immunity 2009 Oct; 10(7):607-15. ACTIVE LIWA PUBLICATIONS REPORT www.liwa.uwa.edu.au 53

ACTIVE LIWA PUBLICATIONS REPORT Waterer GW. Limiting antibiotic use in respiratory tract infections have we gone too far? Chest 2009 May; 135(5):1118-20. Wong CA, Lee O, Kennedy Y, Kenealy H, Hood C, Sivakumaran P, Lee YCG. The training, experience and confidence of junior doctors in performing pleural procedures. New Zealand Medical Journal 2009; 122:23-32. Wrightson JM, Stanton AE, Maskell NA, Davies RJO, Lee YCG. Pseudochylothorax without pleural thickening time to reconsider pathogenesis? Chest 2009; 136:1144-1147. Yu WC, Yeung YC, Chang Y, Tsang YL, Kwong KC, Kwok HC, Lee YCG. Use of endobronchial one-way valves reveals questions on etiology of spontaneous pneumothorax: report of three cases. Journal Cardiothoracic Surgery 2009; 4:63. Zhang Y, Wu JH, Vickers JJ, Ong SL, Temple SE, Mori TA, Croft KD, Whitworth JA. The role of 20-hydroxyeicosate-traenoic acid in adrenocorticotrophic hormone and dexamethasone-induced hypertension. Journal of Hypertension 2009 Aug; 27(8):1609-16. Conference Abstracts Baltic S, Thompson PJ, Fogel-Petrovic M. -synuclein affects dendritic cells differentiation, Thoracic Society of Australia and New Zealand Annual Scientific Meeting, March 2009, Darwin Australia. Respirology; 2009: 14: TP 067. Baltic S, Thompson PJ, Fogel-Petrovic M. -synuclein suppresses dendritic cell differentiation. Thoracic Society of Australia and New Zealand WA meeting, October 2009, Mandurah Australia. Beauchamp MK, Hill K, Goldstein RS, Janaudis-Ferreira T, Brooks D. Impairments in balance discriminate fallers from non-fallers in COPD. American Thoracic Society International Conference, March 2009, San Diego USA. Bhoola K, Ng A, Wong J, Shelton B, Shaw O, Misso N, Thompson P. Expression and epigenetic regulation of kallikreins and kinin receptors in pleural mesothelioma cells. Thoracic Society of Australia and New Zealand Annual Scientific Meeting, March 2009, Darwin Australia. Respirology 2009; 14 (Suppl. 1):A65. Bhoola K, Sia Y, Shaw O, Misso N, Thompson P. Expression and demethylation of kallikrein and kinin receptor genes in lung carcinoma cells. Joint Conferenceof the 5th International Symposium of Peptide Receptors and Kinin, June 2009, Quebec City Canada. Bhoola K, Wong J, Ng A, Shaw O, Misso N, Thompson P. Expression and epigenetic regulation of kallikrein and kinin receptors in pleural mesothelioma cells. Mesothelioma Applied Research Foundation Symposium on Malignant Mesothelioma, June 2009, Washington DC. Cecins N, Jenkins S. Does gender affect outcomes of pulmonary rehabilitation in patients with chronic obstructive pulmonary disease? Thoracic Society of Australia and New Zealand Annual Scientific Meeting, March 2009, Darwin Australia. Respirology 2009; 14 (Suppl.1):A57. Cheah HM, Ngoh E, Watkins N, Lee YCG, Thomas C, Mutsaers SE. The role of the Hedgehog pathway in the development of malignant mesothelioma. TSANZ WA meeting, October 2009, Mandurah Australia. Cheah F, Arthaningtyas E, Williams C, Thompson PJ. Expression of wild-type and a novel splice variant of GPCR A in human lung cells. Thoracic Society of Australia and New Zealand WA meeting, October 2009, Mandurah Australia. Chung LP, Winship P, Phung S, Lake F, Waterer G. Two year Survival in COPD Patients Following First Non-Invasive Ventilation for Acute Type II Respiratory Failure. Thoracic Society of Australia and New Zealand Annual Scientific Meeting, March 2009, Darwin Australia. Chung LP, Shi J, Baltic S, Waterer G, Thompson PJ. Prevalence of beta2 adrenergic receptor polymorphisms in an Australian caucasian population with severe asthma compared with mild and non asthmatics. Thoracic Society of Australia and New Zealand WA meeting, October 2009, Mandurah Australia. Dunn M, Baltic S, Thompson PJ. Proinflammatory Stimuli Varies the Expression of Prostaglandin-E Receptors in Human Respiratory Epithelium. Thoracic Society of Australia and New Zealand WA meeting, October 2009, Mandurah Australia. Fogel-Petrovic M, Baltic S, Thompson PJ. Dendritic cells (DC) susceptibility to synuclein-induced apoptosis depends on DC maturation status, Thoracic Society of Australia and New Zealand Annual Scientific Meeting, March 2009, Darwin Australia. Respirology; 2009: 14: TP 064. Fogel-Petrovic M, Baltic S, Thompson P. Dendritic cells (DC) susceptibility to synuclein-induced apoptosis depends on DC maturation status. Thoracic Society of Australia and New Zealand Annual Scientific Meeting, March 2009, Darwin Australia. Respirology 2009; 14 (Suppl. 1): A47. 54 2009 Annual Report Lung Institute of Western Australia Inc.

Fowler R, Maiorana A, Jenkins S, O Driscoll G, Gabbay E. Exercise induced pulmonary arterial hypertension is clinically important. American Thoracic Society International Conference 2009, San Diego, USA. American Journal of Respiratory and Critical Care Medicine 2009; 179:A4135. Fowler R, Maiorana A, Jenkins S, O Driscoll G, Gabbay E. Exercise induced pulmonary arterial hypertension is clinically important. Thoracic Society of Australia and New Zealand Annual Scientific Meeting, March 2009, Darwin Australia (Anne Woolcock Young Investigator Award). Respirology 2009; 14 (Suppl 1):A17. Fowler R, Maiorana A, Jenkins S, O Driscoll G, Gabbay E. Exercise Induced pulmonary arterial hypertension reflects a pulmonary vasculopathy and is clinically important. Thoracic Society of Australia and New Zealand Annual Scientific Meeting, March 2009, Darwin Australia. (Young Investigator Award Finalist). Ganderton L, Gabbay E, Fowler R, Gain K, Lunt D, Winship P, Jenkins S. Is exercise training safe for patients with pulmonary arterial hypertension? Thoracic Society of Australia and New Zealand Annual Scientific Meeting March 2009, Darwin Australia. Respirology 2009; 14 (Suppl. 1):A68. Ganderton L, Gabbay E, Fowler R, Gain K, McKenna S, Jenkins S. Validation of the Cambridge Pulmonary Hypertension Outcome Review for an Australian and New Zealand PAH population. Thoracic Society of Australia and New Zealand Annual Scientific Meeting, March 2009, Darwin Australia. Respirology 2009; 14 (Suppl. 1):A69. Higton AM, Whale CI, Fernandez NA, Jary C, Lawrence S, Musk M, Gabbay E. Comparison of Pulmonary Hypertension Complicating Lung Disease and Pulmonary arterial Hypertension. Thoracic Society of Australia and New Zealand, Annual Scientific Meeting, March 2009, Darwin Australia. Higton AM, Whale CI, Fernandez NA, Jary C, Lawrence S, Musk M, Gabbay E. Multiple co-morbidities are common in patients referred to a regional adult pulmonary hypertension service. American Thoracic Society International Conference, March 2009, San Diego USA. Hill K, Woon L, Dolmage TE, Goldstein R, Brooks D. Field-based walk tests elicit similar end-test measures of heart rate and oxygen uptake as incremental cycle ergometry tests in patients with COPD. Canadian Respiratory Conference, April 2009, Toronto Canada. Hill K, Woon L, Dolmage TE, Goldstein R, Brooks D. Relationships between energy expenditure and measurements of exercise capacity in patients with chronic obstructive pulmonary disease. Canadian Respiratory Conference, April 2009, Toronto Canada. Ibrahim M, Whale C, Higton A, Lawrence S, Jary C, Gabbay E, Musk M. The relationship between gasto-oesophageal reflux and Bronchiolitis Obliterans Syndrome after lung transplantation. European Respiratory Society, September 2009, Vienna Austria. Jaffe A, Laverty A, Chambers D, Wislher M, Twiss J, Glaspole I, Gabbay E. Establishment of a web based registry for orphan lung diseases in Australia and New Zealand. Thoracic Society of Australia and New Zealand, Annual Scientific Meeting, March 2009, Darwin Australia. Janaudis-Ferreira T, Hill K, Robles-Ribeiro P, Beauchamp M, Goldstein R, Wadell K, Brooks D. Cardiorespiratory responses to an incremental unsupported upper limb exercise test in people with COPD. American Thoracic Society International Conference, March 2009, San Diego USA. Lau HL, O Donoghue R, Ernst M, Anderson G, Jones J, Mutsaers S. The IL-6 Family of Cytokines Modulate Bleomycin-Induced Lung Fibrosis.TSANZ YIA finalist. Thoracic Society of Australia and New Zealand WA meeting, October 2009, Mandurah Australia. Misso N, Aggarwal S, Sutton J, Thompson P. Effects of ironcontaining PM10 and urban PM10 on cytokine production by dendritic cells and macrophages. Thoracic Society of Australia and New Zealand Annual Scientific Meeting, March 2009, Darwin Australia. Respirology 2009; 14 (Suppl. 1):A66. Mutsaers SE, Gulliver RL, Spencer H, Lane D, O Donoghue RJJ, Knight DA, Prele CM. SOCS3 expression correlates with reduced STAT3 expression in IPF fibroblasts. Respirology 2009; 14 (Suppl. 1):A46. Mutsaers SE, Wilkosz S, Pugazhenthi K. The effect of HGF on mesothelial cell plasminogen activator & plasminogen activator inhibitor secretion. Thoracic Society of Australia and New Zealand WA meeting, October 2009, Mandurah Australia. O Donoghue RJJ, Jarnicki AG, Wang B, Prele CM, Dousha L, Jones JE, Zhou HJ, Anderson GP, Ernst M, Mutsaers SE. GP130-STAT3 signalling can promote pulmonary fibrosis without SMAD3 in a mouse model. Respirology 2009; 14 (Suppl 1):A23. Pearce-Brown C, Glasgow NJ, Jeon Y-H, Douglas, K, Jenkins S. Health literacy and self management in COPD: the same, different or misunderstood? General Practice and Primary Health Care Research Conference, July 2009, Melbourne Australia. Smith K, Jenkins S, Williamson J, Cecins N, Hillman D, Eastwood P. Maximal treadmill and cycle exercise tests in people with COPD. Thoracic Society of Australia and New Zealand Annual Scientific Meeting, March 2009, Darwin Australia. Respirology 2009; 14 (Suppl. 1):A56. ACTIVE LIWA PUBLICATIONS REPORT www.liwa.uwa.edu.au 55

ACTIVE LIWA PUBLICATIONS REPORT Stevens W, Byron J, Kermeen F, Tymms K, Gabbay E, Proudman S. Assessment of cardiopulmonary complications of systemic sclerosis using the Australian Scleroderma Screening Program (ASSP) database. Thoracic Society of Australia and New Zealand Annual Scientific Meeting, March 2009, Darwin Australia. Whale C, Higton A, Lawrence S, Jary C, Gabbay E, Musk M. HLA matching before lung transplantation and the risk of developing Bronchiolitis Obliterans Syndrome. American Thoracic Society International Conference, March 2009, San Diego USA. Whale C, McMorrow J, Higton A, Chambers D, Gabbay E, Musk M. Pleural cavity irrigation with Taurolidine during lung transplantation may reduce post-operative empyema. American Thoracic Society International Conference, March 2009, San Diego USA. Wickerson L, Hill K, Woon L, Goldstein R, Overend T, Brooks D. Cardiorespiratory responses to the 6 minute walk test: a comparison of healthy and COPD participants. Canadian Respiratory Conference, April 2009, Toronto Canada. Review Articles Heffner JE, Holgate ST, Chung KF, Niederman MS, Daley CL, Jett JR, Wells AU, Tapson VF, Stradling JR, Light RW, Hansell DM, Pronovost PJ and Lee YCG. The road ahead to respiratory health experts chart future research directions. Respirology 2009 Jul; 14(5):625-636. Higton A, Whale C, Musk M, Gabbay E. Review of the management of pulmonary arterial hypertension in pregnancy. Internal Medicine Journal 2009 (in press). Hooper C, Lee YCG, Maskell NA. Interferon Gamma Release Assays (IGRAs) for the diagnosis of TB pleural effusions: hype or real hope? Current Opinion in Pulmonary Medicine 2009 Jul; 15(4):358-365. Lee YCG. Respirology: To unpathed waters and undreamed shores (Editorial). Respirology 2009; 14(5):622. Shaw OM, Misso NL, Shelton BP, Bhoola KD. Human genetic variation: a foundation for rational diagnosis and individualized treatment of lung cancer. Current Pharmacogenomics and Personalized Medicine 2009 Jun; 7(2):133-145. Strange G, Fowler R, Jary C, Dalton B, Gabbay E. Multidisciplinary approach to management of pulmonary arterial hypertension. Journal of Multidisciplinary Health Care 2009 (in press). Vally H, Misso NL, Madan V. Clinical effects of sulphite additives. Clinical and Experimental Allergy 2009; 39(11):1643-1651. Waterer GW, Robertson H. Bioterrorism for the respiratory physician. Respirology 2009 Jan; 14(1): 5-11. Waterer GW, Wunderink RG. Respiratory infections a current and future threat. Respirology 2009 Jul; 14(5):651-5. Book Chapters Davies HE and Lee YCG. Mesothelioma. In: Maskell NA and Miller A, eds. Oxford Desk Reference: Respiratory Medicine, pp. 346-349. Oxford, U.K.: Oxford University Press, 2009. Light RW, Lee YCG. Pneumothorax, Chylothorax, Hemothorax and Fibrothorax. In: Murray J, Nadel J, Mason R and Broaddus VC, eds. Textbook of Respiratory Diseases, 5th edition: (in press). Mishra E, Davies HE and Lee YCG. Malignant pleural disease in primary lung cancer. In: Spiro SG, Janes SM, Huber RM, eds. Thoracic Malignancies, 3rd edition: European Respiratory Monograph, pp. 318-335. Sheffield, U.K.: European Respiratory Society Journals Ltd, 2009. Pugazhenthi, K. Melatonin and its role in the inflammatory processes. In: The Pineal Gland and Melatonin: Recent Advances in Development, Imaging, Disease and Treatment. Turgut M (ed.) NOVA, 2009 (in press). Stathopoulos GT, Hegmans JJ and Lee YCG. Translational research for pleural diseases. In: Bouros D, ed. Pleural Disease, 2nd edition. Series of Lung Biology in Health and Disease. Informa Healthcare; New York (in press). 56 2009 Annual Report Lung Institute of Western Australia Inc.

grants report Bhoola K, Misso NL, Thompson PJ. Expression and epigenetic regulation of the kallikrein-kinin receptor genes in mesothelioma. Slater & Gordon Asbestos Research Fund 2009, $10,000. Konstantinov, I. Delayed phase of remote ischaemic preconditioning: clinical applications and the role of kallikrein-kinin pathway. National Health and Medical Research Council, Australia, 2009 2010, $134,325. Lee YCG, Waterer GW, Kendell P, Geelhoed E. Novel community-based care for malignant pleural effusions. State Health Research Advisory Council, WA, 2009 2010, $160,000. Mackay C, Foster P, Thompson PJ, Black J, O Neil R, Berens N, Gibson P, Weinstein P, Marks G, Jenkins C. University of Western Australia, Centre for Asthma, Allergy & Respiratory Research. Cooperative Research Centre for Asthma & Airways, 2005 2010, $4,456,304. Mutsaers SE, Lee YCG, McAnulty RJ. Transforming growth factor beta signalling in malignant mesothelioma growth and collagen production. National Health and Medical Research Council, Australia, 2007 2009, $171,162. Mutsaers SE, Lee YCG. The role of the Hedgehog signaling pathway in asbestos associated malignant mesothelioma. National Health and Medical Research Council, Australia, 2009 2011, $541,500. Mutsaers SE. Hedgehog signalling study in mesothelioma. Mesothelioma Applied Research Foundation, 2009 2010, $64,563. Prele C. M1/M2 macrophage activation and systemicassociated lung fibrosis. Arthrisitis Foundation of Australia, 2009 2010, $20,000. Prele C. SOCS regulation of gp130-mediated signaling oathways in SSc-induced lung fibrosis. University of Western Australia Start-up Grant, 2009, $20,000. Robinson B, Thompson PJ, Musk M, Lake R, Mutsaers SE, Nowak A. Centre of Clinical Research Excellence Grant in Pulmonary and Environmental Medicine. National Health and Medical Research Council, Australia, 2007 2011, $670,000 (LIWA share). Thompson PJ, Bhoola KD. Lung cancer: Activation of stem cells by tissue kallikrein and kinins to form vascular lifelines. Group of Eight/DAAD- Australian- German Research Co-operation Scheme, 2009 2010, $20,000. Thompson PJ. The RAGE Grant. Sir Charles Gairdner Hospital Research Grant, 2009 2010, $51,907. Waterer G, Kelly P. Establishing a Rapid Alert System for Severe Respiratory Illness in Adults: The FluCAN Surveillance system. The Australian National University, 2009, $19,875. ACTIVE LIWA GRANTS REPORT www.liwa.uwa.edu.au 57

THE LUNG INSTITUTE OF WESTERN AUSTRALIA (INC) financial report 58 Statement by the Board 59 61 Income and Expenditure Statement 62 63 Balance Sheet 64 65 Notes to and forming part of the Financial Report 66 67 Auditor s Report FINANCIAL REPORT Statement by the Board The Board has determined that the Institute is not a reporting entity and therefore there is no requirement to apply Accounting Standards and other mandatory professional reporting requirements (Urgent Issues Group Consensus Views) in the preparation of these financial statements. The Board has determined that this special purpose financial report should be prepared in accordance with the accounting policies outlined in Note 1 to the Accounts. In the opinion of the Board: (a) The accompanying Income and Expenditure Statement is drawn up so as to give a true and fair view of the profit of the Institute for the year 1 January 2009 to 31 December 2009. (b) The accompanying Balance Sheet is drawn up so as to give a true and fair view of the state of affairs of the Institute as at that date. (c) At the date of this statement there are reasonable grounds to believe that the Institute will be able to pay its debts as and when they fall due. 58 2009 Annual Report Lung Institute of Western Australia Inc. (d) The Institute has, in respect of the financial year: (i) kept such accounting records as correctly record and explain its transactions and financial position; (ii) so kept its accounting records that true and fair accounts of the Institute can be prepared from time to time; and (iii) so kept its accounting records that the accounts of the Institute can be conveniently and properly audited in accordance with the Corporations Law. This Statement is made in accordance with a resolution of the Board and is signed for and on behalf of the Board by: Signed and dated this BOARD MEMBER day of

THE LUNG INSTITUTE OF WESTERN AUSTRALIA (INC) income and expenditure statement for the year ended 31 December 2009 2009 2008 $ $ INCOME Fundraising 13,677 2,841 Clinical Trials 687,675 677,631 Respirology 241,874 106,105 Port Hedland Dust & Cells - 60,486 Employee Entitlement 110,102 7,809 Donations Received 38,110 12,006 Honours & Training Fees - 22,016 Interest Received 96,092 55,437 Reimbursement Income 3,625 908 Membership Fees 4,685 4,556 National Research Grants 1,191,441 1,136,044 Scholarship Recouped - 6,338 Local Research Grants 602,269 555,999 Sponsorship 24,182 - Research Income 10,000 - Salary Recouped 6,873 - Research Support 182,494 - TOTAL INCOME 3,213,099 2,648,176 www.liwa.uwa.edu.au 59 FINANCIAL REPORT

THE LUNG INSTITUTE OF WESTERN AUSTRALIA (INC) income and expenditure statement contd. for the year ended 31 December 2009 FINANCIAL REPORT 60 2009 2008 $ $ EXPENDITURE Accounting Fees 9,399 8,999 Advertising & Promotion 51,666 8,916 Awards 6,750 33,093 Amortisation - Trademarks 494 494 Auditors Remuneration 5,967 4,064 Bank Charges 3,403 1,592 Bad Debts 1,156 - Bookkeeping Fees 1,381 17,938 Clinical Trial Expenses 51,281 41,462 Computer Requisites 41,441 24,655 Contract Research Expenses 399,637 319,302 Courier 8,467 3,700 Depreciation 49,013 29,240 Entertainment 3,380 10,622 Function & Conference Expenses 26,026 20,149 Fundraising Expenses 18,245 960 Symposium 28,466 - Insurance 19,517 18,478 Interest 1,557 86 Interest UWA Long Term Pool 62,825 - Lease Charges Computer 3,817 394 Legal 2,550 - Printing, Stationery & Stamps 17,015 10,519 Project Expenses 93,813 198,326 Publications & Annual Reports 13,704 19,818 Rent Genetics Laboratory 30,000 20,000 2009 Annual Report Lung Institute of Western Australia Inc.

THE LUNG INSTITUTE OF WESTERN AUSTRALIA (INC) income and expenditure statement contd. for the year ended 31 December 2009 2009 2008 $ $ Repairs & Maintenance 5,450 5,518 Research Partner Funds 73,515 106,747 Staff Recruitment - 2,250 Staff Amenities 4,494 2,067 Staff Training 3,915 3,302 Subscriptions 10,682 8,161 Superannuation 150,279 126,754 MHRIF Allocation - 14,295 Sponsorship 229 1,098 Telephone 7,103 3,081 Travel & Accommodation 34,655 45,114 Wages 1,678,935 1,420,526 Workers Compensation 14,568 10,443 TOTAL EXPENDITURE 2,934,795 2,542,164 NET SURPLUS 278,304 106,012 www.liwa.uwa.edu.au 61 FINANCIAL REPORT

THE LUNG INSTITUTE OF WESTERN AUSTRALIA (INC) balance sheet as at 31 December 2009 2009 2008 $ $ INSTITUTE FUNDS Accumulated Surplus 1,741,328 1,463,024 Represented by CURRENT ASSETS Cash at Bank 550,388 521,439 Term Deposits 730,000 612,183 UWA Long Term Pool 288,401 307,965 Petty Cash Imprest 1,513 500 CTU Petty Cash 430 575 CTU Clearing Account - 1,315 Coupon Select Deposit 115419 250,000 - CRC Partner Cont Prepayment 96,485 - Research Matching Clearing Account - 9,375 Accrued Interest Term Deposit 6,951 Sundry Debtors 434,027 58,116 Prepaid Expenses 15,237 12,743 Undeposited Funds 8,015 - University Grants - 162,884 TOTAL CURRENT ASSETS 2,381,447 1,687,095 FINANCIAL REPORT CURRENT LIABILITIES University Grants 10,880 - Credit Cards 1,799 23 CF Melbourne Cup 25,028 - Sundry Creditors 161,503 61,906 PAYG Withholding 14,760 14,565 Prepaid Income 264,252-62 2009 Annual Report Lung Institute of Western Australia Inc.

THE LUNG INSTITUTE OF WESTERN AUSTRALIA (INC) balance sheet contd. as at 31 December 2009 2009 2008 $ $ Provision for Superannuation 34,628 9,887 Provision for Workers Compensation 15,117 6,431 Accrued Wages 61,523 - Scholarship Curtin University 40,000 - GST Payable 8,070 (1,225) TOTAL CURRENT LIABILITIES 637,560 91,587 NET CURRENT ASSETS 1,743,887 1,595,508 NON-CURRENT ASSETS Plant & Equipment at Cost 270,532 218,627 Less: Accumulated Depreciation (118,316) (90,899) 152,216 127,728 Office Furniture & Equipment at Cost 150,643 107,600 Less: Accumulated Depreciation (100,811) (79,214) 49,832 28,386 Trademarks & Patents at Cost 5,565 5,565 Less: Accumulated Amortisation (5,189)) (4,695)) 376 870 TOTAL NON CURRENT ASSETS 202,424 156,984 NON-CURRENT LIABILITIES Hire Purchase Creditors 25,617 - Leave Provisions 179,366 289,468 TOTAL NON-CURRENT LIABILITIES 204,983 289,468 NET ASSETS 1,741,328 1,463,024 www.liwa.uwa.edu.au 63 FINANCIAL REPORT

THE LUNG INSTITUTE OF WESTERN AUSTRALIA (INC) notes to and forming part of the financial report for the year ended 31 December 2009 FINANCIAL REPORT Note 1 Statement of Accounting Policies This Financial Report is a special purpose financial report prepared in order to satisfy the financial reporting requirements of the Board and the Associations Incorporation Act (WA). The Board has determined that the Institute is not a reporting entity. This report has been prepared in accordance with the requirements of the following Accounting Standards and other mandatory professional reporting requirements: AASB 110 Events after the Balance Sheet Date AASB 1021 Depreciation of Non-Current Assets AASB 1031 Materiality The Report is prepared on an accruals basis, and is based on historic costs and does not take into account changing money values or, except where specifically stated, current valuations of non-current assets. No other applicable Accounting Standards, Australian Accounting Interpretations or other authoritative pronouncements of the Australian Accounting Standards Board have been applied. 64 2009 Annual Report Lung Institute of Western Australia Inc. The Following material accounting policies, which are consistent with the previous period unless otherwise stated, have been adopted in the preparation of this financial report. a) Property, Plant & Equipment Each class of property, plant and equipment is carried at cost less, where applicable, any accumulated depreciation. The depreciable amount of all property, plant and equipment is depreciated over the useful life of the assets of the association commencing from the time the asset is held ready for use. b) Employee Benefits Provision is made for the association s liability for employee benefits arising from services rendered by employees to the end of the reporting period. Employee benefits have been measured at the amounts expected to be paid when the liability is settled. c) Provisions Provisions are recognised when the association has a legal or contructive obligation, as a result of past events for which it is probable that an outflow of economic

benefits will result and that outflow can be reliably measured. Provisions are measured at the best estimate of the amounts required to settle the obligation at the end of the reporting period. d) Cash and Cash Equivalents Cash and cash equivalents includes cash on hand, deposits held at call with banks, and other short-term highly liquid investments with original maturites of three months or less. e) Revenue and Other Income Interest revenue is recognised using the effective interest rate method, which for floating rate financial assets is the rate inherent in the instrument. Note 2: Accumulated Surplus 2009 2008 $ $ Accumulated surplus at beginning of year 1,463,024 1,357,012 As previously stated Prior period adjustment - - Accumulated surplus at beginning of year 1,463,024 1,357,012 Surplus for the year 278,304 106,011 Accumulated surplus at the end of the year 1,741,328 1,463,024 Grant and donation income is recognised when the entity obtains control over the funds, which is generally at the time of receipt. All revenue is stated net of the amount of goods and services tax (GST). f) Goods and Service Tax Revenues, expenses and assets are recognised net of the amount of GST. Receivables and payables on the Balance Sheet are shown inclusive of GST. www.liwa.uwa.edu.au 65 FINANCIAL REPORT

FINANCIAL REPORT 66 2009 Annual Report Lung Institute of Western Australia Inc.

www.liwa.uwa.edu.au 67 FINANCIAL REPORT

Lung Institute of Western Australia Ground Floor E Block Sir Charles Gairdner Hospital Nedlands Western Australia 6008 Telephone +61 8 9346 3198 Facsimile +61 8 9346 4159 Email Web admin@liwa.uwa.edu.au www.liwa.uwa.edu.au LIWA is a registered charity. All donations over $2 are tax deductable. ABN: 78 098 197 636 DESIGN BY CREATIVE PAGE