2012...2015. T-Cell Lymphomas: We are illuminating the darkest of tunnels



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ISTITUTO DI EMATOLOGIA L. E A. SERÀGNOLI ALMA MATER STUDIORUM Università di Bologna DIPARTIMENTO DI MEDICINA SPECIALISTICA. DIAGNOSTICA E SPERIMENTALE 2012...2015. T-Cell Lymphomas: We are illuminating the darkest of tunnels PROGRAM Bologna, ROYAL HOTEL CARLTON April 27-29, 2015 Presidents: Stefano A. Pileri Pier Luigi Zinzani Co-President: Michele Cavo Honorary President: Sante Tura

Requested Auspices: UNIVERSITÀ DEGLI STUDI DI BOLOGNA REGIONE EMILIA-ROMAGNA AZIENDA OSPEDALIERO-UNIVERSITARIA DI BOLOGNA AIL ASSOCIAZIONE ITALIANA CONTRO LE LEUCEMIE LINFOMI E MIELOMA SEZIONE DI BOLOGNA SIE-SOCIETÀ ITALIANA DI EMATOLOGIA Scientific Secretariat Pier Luigi Zinzani Istituto di Ematologia e di Oncologia Medica Lorenzo e Ariosto Seràgnoli Università degli Studi di Bologna Via Massarenti, 9-40138 Bologna, Italy Phone +39 051 6363680 - Fax +39 051 6364037 E-mail: pierluigi.zinzani@unibo.it Organizing Secretariat Studio E.R. Congressi - Triumph Group Via Marconi, 36-40122 Bologna, Italy Phone +39 051 4210559 - Fax +39 051 4210174 E-mail: ercongressi@thetriumph.com www.ercongressi.it

Faculty: Ranjana Advani Stanford, USA Stephen M. Ansell Rochester, USA Martine Bagot Paris, France Emilio Berti Milano, Italy Lorenzo Cerroni Graz, Austria Wing C. Chan Duarte, USA Bruce D. Cheson Washington, USA Bertrand Coiffier Lyon, France Paolo Corradini Milano, Italy Francesco A. D'Amore Aarhus, Denmark Ghandi Damaj Amiens, France Claire Dearden London, United Kindom Reinhard Dummer Zurich, Switzerland Madeleine Duvic Houston, USA Brunangelo Falini Perugia, Italy Michelle Fanale Houston, USA Massimo Federico Modena, Italy Adolfo Ferrando New York, USA Francine Foss New Haven, USA Gianluca Gaidano Novara, Italy Carlo Gambacorti-Passerini Monza, Italy Philippe Gaulard Créteil, France Martin-Leo Hansmann Frankfurt am Main, Germany Steven M. Horwitz New York, USA Hui-Qiang Huang Guangzhou, China Giorgio Inghirami New York, USA Arnaud Jaccard Limoges, France Elaine S. Jaffe Bethesda, USA Youn H. Kim Stanford, USA Won Seog Kim Seoul, Korea Yok Lam Kwong Hong Kong, China Bharat Nathwani Los Angeles, USA Owen A. O Connor New York, USA Francesco Onida Milano, Italy Fabrizio Pane Napoli, Italy Marco Paulli Pavia, Italy Stefano A. Pileri Bologna-Milano, Italy Nicola Pimpinelli Firenze, Italy Miguel A. Piris Madrid, Spain H. Miles Prince Melbourne, Australia Barbara Pro Philadelphia, USA Pietro Quaglino Torino, Italy Vincent Ribrag Villejuif, France Elena Sabattini Bologna, Italy Marco Santucci Firenze, Italy Kerry J. Savage Vancouver, Canada Andrei R. Shustov Seattle, USA Helene Sicard Marseille, France Kensei Tobinai Tokyo, Japan Lorenz Trümper Göttingen, Germany Kunihiro Tsukasaki Chiba, Japan Julie M. Vose Omaha, USA Sean Whittaker London, United Kingdom Rein Willemze Leiden, The Netherlands Motoko Yamaguchi Tsu, Japan Pier Luigi Zinzani Bologna, Italy Emanuele Zucca Bellinzona, Switzerland 2012...2015. T-Cell Lymphomas: We are illuminating the darkest of tunnels

Monday April 27, 2015 4 02.30 p.m. Welcome and Introduction The T-cell World Chairmen: F. Pane, S.A. Pileri 02.45 p.m. News from WHO E.S. Jaffe 03.05 p.m. Epidemiologic view on ALCL of the breast H.M. Prince 03.25 p.m. Prognostic models in PTCL J.M. Vose 03.45 p.m. Prognostic models in CTCL Y.H. Kim 04.05 p.m. The role of PET and T-cell specific response criteria B.D. Cheson Conventional and ongoing therapies Chairmen: R. Advani, P.L. Zinzani Standard front-line treatment of: 04.25 p.m. PTCL-nos K.J. Savage 04.45 p.m. «The rest» of PTCL S.M. Horwitz 05.05 p.m. CTCL R. Willemze 05.25 p.m. ATLL K. Tobinai and the ongoing potential new alternatives: 05.45 p.m. ACT-1/ACT-2 F.A. D Amore, L. Trümper 06.10 p.m. CHOP vs. GEM-P C. Dearden 06.20 p.m. CHOP vs. A+CHP R. Advani 06.30 p.m. CHOP vs Ro-CHOP B. Coiffier

5 Tuesday April 28, 2015 PTCL: morphology and pathobiology Chairmen: B. Falini, B. Nathwani PTCL-NOS: 08.30 a.m. Histology E. Sabattini 08.50 a.m. Lennert s lymphoma M.L. Hansmann 09.10 a.m. Molecular genotyping A. Ferrando 09.30 a.m. Gene expression profiling W.C. Chan 09.50 a.m. AITL P. Gaulard 10.10 a.m. ALCL S.A. Pileri 10.30 a.m. Coffee Break PTCL and CTCL CD30+ Chairmen: M. Federico, M. Paulli 10.45 a.m. CD30+ expression: real or virtual? S.A. Pileri Brentuximab vedotin in: 11.05 a.m. ALCL B. Pro 11.25 a.m. PTCL-NOS/AILT M. Fanale 11.45 a.m. CTCL M. Duvic 2012...2015. T-Cell Lymphomas: We are illuminating the darkest of tunnels

6 NK/T-cell lymphoma: the role of asparaginase Chairmen: W.S. Kim, K. Tobinai 12.05 p.m. Japanese experience M. Yamaguchi 12.20 p.m. Hong Kong experience Y.L. Kwong 12.35 p.m. French experience A. Jaccard 12.50 p.m. American experience R. Advani 01.05 p.m. Chinese experience H.Q. Huang 01.20 p.m. Lunch PTCL: the combo-step of the new drugs Chairmen: B.D. Cheson, P.L. Zinzani 02.30 p.m. Pralatrexate with O.A. O Connor 02.45 p.m. Romidepsin and M. Fanale 03.00 p.m. Belinostat plus F. Foss 03.15 p.m. Everolimus with W.S. Kim 03.30 p.m. Lenalidomide and S.M. Horwitz

7 PTCL: the new single agents Chairmen: F. Foss, E. Zucca 03.45 p.m. Alisertib O.A. O Connor 04.00 p.m. Aplidin V. Ribrag 04.15 p.m. PD-1, PDL-1 S.M. Ansell 04.30 p.m. Copanlisib P.L. Zinzani 04.45 p.m. What from the basket of BTK and PI3K inhibitors? S.M. Horwitz 05.00 p.m. Carlfizomib J.M. Vose 05.15 p.m. Bendamustine G. Damaj 05.30 p.m. Crizotinib C. Gambacorti-Passerini 2012...2015. T-Cell Lymphomas: We are illuminating the darkest of tunnels

Wednesday April 29, 2015 8 CTCL: morphology and pathobiology Chairmen: E. Berti, S.A. Pileri 08.30 a.m. Histology M. Santucci 08.45 a.m. Gene expression profiling S. Whittaker 09.00 a.m. The spectrum of CD8+ CTCL E. Berti 09.15 a.m. Unusual clinicopathologic variants of CTCL L. Cerroni CTCL and New Drugs: Emerging combination strategies Chairmen: N. Pimpinelli, P. Quaglino 09.30 a.m. Pralatrexate with M. Duvic 09.45 a.m. Pegylated liposomal doxorubicin R. Dummer 10.00 a.m. Bexarotene-containing regimens N. Pimpinelli 10.15 a.m. HS IPH4102 anti-kir3dl2 mab in CTCL H. Sicard Mogamulizumab inside the T-cell family Chairman: K. Tobinai 10.30 a.m. ATLL K. Tsukasaki 10.45 a.m. PTCL K. Tobinai 11.00 a.m. CTCL M. Duvic

9 Important Pre-clinical Model with T-cell lymphoma Chairman: G. Gaidano 11.15 a.m. Putting preclinical pharmacology into perspective O.A. O Connor 11.35 a.m. Experimental models M.A. Piris 11.55 a.m. Animal models G. Inghirami Allotransplant setting Chairman: F. Onida PTCL: 12.15 p.m. American perspective A.R. Shustov 12.30 p.m. European perspective P. Corradini CTCL: 12.45 p.m. European perspective M. Bagot 01.00 p.m. American perspective M. Duvic 01.15 p.m. Closing remarks Arrivederci al 2018! 2012...2015. T-Cell Lymphomas: We are illuminating the darkest of tunnels

General Information Meeting Venue Royal Hotel Carlton Via Montebello, 8-40121 Bologna, Italy Phone +39 051 249361 - Fax +39 051 249724 How To Get There By car: From the motorway, turn into the ring road ("Tangenziale") - Exit 7 Fiera and follow direction city center and railway station. By taxi: From the airport about 30 minutes. By bus: Bus 91 and Aerobus from the airport. By train: From the railway station walking distance. Official Language English. Registration Fee Euro 400,00 (Italian VAT included) The registration fee includes: Conference kit Partecipation in the scientific sessions Attendance Certificate Coffee breaks Lunch Slides of meeting Registrations can be requested submitting the online registration form available on the website: www.ercongressi.it

Scientific Information Slides Slides must be in English. Computer videoprojection will be available in Power Point. Other requirements should be communicated to the Organizing Secretariat as soon as possible. Slides should be handed to the slide center one hour before the beginning of the session and collected at the end. Badge All registered participants, speakers and exhibitors will be given a badge which they must wear to be admitted to the scientific sessions. Attendance certificate A certificate will be given to all participants at the end of the Meeting. Italian CME Credits A request for Italian CME credits have been made as follows: - Provider Studio ER Congressi SRL: ID 828-113853. - No. 12 CME credits for physicians (disciplines: Allergology and Clinical Immunology, Dermatology and Venereology, Hematology, Oncology, Pathological Anatomy, Clinical Biochemistry, Clinical Pathology), biologists and chemists. - Educational objective: guidelines-protocols-procedures. European CME Credits The program of the T-Cell Lymphomas: We are illuminating the darkest of tunnels has been reviewed and approved for CME accreditation by the European Hematology Association CME Unit. The EHA-CME Unit has approved this educational activity for no. 16 CME credits for physicians and biologists. To request credits, please fill in the questionnaire and return it to the registration desk at the end of the meeting. We remind you that it is necessary to create an EHA-CME account on the EHA website: http://eha-cme.org. Changes Parts of the program may be changed without notice.

Scientific Coordinator Pier Luigi Zinzani Istituto di Ematologia e di Oncologia Medica Lorenzo e Ariosto Seràgnoli Università degli Studi di Bologna Via Massarenti, 9-40138 Bologna, Italy Phone +39 051 6363680 - Fax +39 051 6364037 E-mail: pierluigi.zinzani@unibo.it Organizing Secretariat Studio E.R. Congressi - Triumph Group Via Marconi, 36-40122 Bologna, Italy Phone +39 051 4210559 - Fax +39 051 4210174 E-mail: ercongressi@thetriumph.com www.ercongressi.it progetto www.struchel.com