Wissensforum 1 st SynTOP Smart Synthesis and Technologies for Organic Processes '. *«Conference Potsdam, June 11-13 2008 VDI-Berichte 2039
Contens Page Preface 1 Sf. V. Ley L A. Hulshof F. Schneider, B. Ondruschka H. Lehmann U. Beifuss C. 0. Kappe M. G. Organ U. Kunz, A. Kirschning A. Kirschning U. Kunz D. M. Roberge S. Hubner, K. Jahnisch, U. Bentrup, L. Kupper, U. Budde, T. Dietrich, A. Freitag Lectures New Tools for Molecule Makers: Emerging Technologies Towards scaling up heterogeneous microwaveassisted reactions Microwave enhanced Milling Organic Chemistry Scale-up and Microwave Technology: A Contradiction? A New Microwave-Assisted Catalytic Domino Process for the Synthesis of N-Heterocycles Continuous Flow Catalytic Transfer Hydrogenations Using Immobilized Palladium Nanoparticles Heated by Microwave Irradiation Metals, Microwaves and the Magic They Create Monolithic composite micro - reactors: an enabling technology for improved organic synthesis Chemistry in Flow - Enabling Technologies in Organic Synthesis using PASSflow reactors Industrial Design and Use of Microreactors in the Fine Chemical and Pharmaceutical Industry An Ozonolysis-Reduction-Sequence for the Synthesis of Pharmaceutical Intermediates in Microstructured Devices 5 9 11 15 21 27 33 37 41 47 53
Page K. T. Zuidhof, The performance of the Beckmann rearrangement M. H. J. M. de Croon, to caprolactam in a number of micro reactors J. C. Schouten 57 S. Rothstock, V. Hessel, P. Lob, H. Lowe, B. Werner P. Pfeifer, F. Ozkan, O. Gorke, K. Schubert S. Braune M. Matlosz G A. Groli, L. Abahmane, T. Thelemann, M. Fischer, J. M. Kohler K. Geyer, P. H. Seeberger P. Watts M. Schwarzer, Ph. Trefz, D. Roeseling, St. Loebbecke, S. Janietz, H. Krueger Th. Wirth Biphasic Suzuki coupling in mini tube reactor Novel reactor design for heterogeneously catalysed gas-liquid organic synthesis Efficient Implementation of Intensified Processes in Fine Chemicals Manufacture - Key Success Factors Microprocess Engineering, Process Intensification and Multiscale Design Macrocycle Synthesis at Short Residence Times Microreactors as the Key to the Chemistry Laboratory of the Future Organic Synthesis in Continuous Flow Reactors Analyzing the Synthesis of Semiconducting PPV Polymers in Microreactors Enhancement of Reaction Rates by Segmented Flow Technique: New Aspects for Organic Synthesis 61 67 73 77 85 91 99 101 103
Page M. Poliakoff, R. A. Bourne Catalytic Reactions in Supercritical Fluids 105 J. Arras, M. Steffan, Hydrogenation of Citral using Ionic Liquids as Bulk 109 P. Claus Solvents or as Supported Ionic Liquid Layers A. Stark, M. Sellin, J. Lifka, B. Ondruschka Ionic Liquids for the Manufacture of Platform Chemicals: 115 Framing Novel Process Windows U. Krtschil, F. Benaskar, V. Hessel, P. L6b Intensified Kolbe-Schmitt Synthesis using 117 Continuous Microreactor Processing, Reactive Ionic Liquids and Microwave Heating P. Wasserscheid Ch. J. Welch D. Kralisch, N. HeMer, R. Erdmann, W. Schmidt, D. Klemm Th. Bayer, D. Kadzimirsz, M. Kinzl, O. Lade R. Ditz E. E. Barth, S. Kopp, D. W. Agar A. Ghaini, D. W. Agar Ionic liquid "solutions" for catalytic transformations 125 Separation and Analysis Technologies in 135 Support of Pharmaceutical Process Research New process strategy for an emerging 141 biopolymer - bacterial produced nanocellulose SIPROCESS - A Micro Process System 143 for challenging reactions Process Intensification - Supporting the Bridge and 149 Paving the Road for a Competitive Chemical Industry Development and characterisation of a microscale 151 permselective enzymatic membrane reactor Microscale Countercurrent Liquid/Liquid Extraction 155
Ch. A.-A. Aissa, Th. Schultz, P. Heidebrecht, K. Sundmacher B. R. Johnson S. Buchholz, L. Mleczko Continuous Mini-channel Membrane Device for the Separation of Organic Mixtures: Experimental and Model-based Evaluation Multi-step chemical processes in a Modular Reactor from Alfa Laval Microreactors in Industrial Applications for Intermediates and APIs Page 161 171 177 O. J. Stange, F. Herbstritt, M. Kroschel, K. Nagy, F. Schael Modular Microprocess Technology - New Devices for Process and Product Development and new Applications 183 T. Illg, V.Hessel, P. Lob G A. GroR, A. Schober, M.Gebinoga, J. M. Kdhler Th. Henkel, Th. Frank F. Ozkan, P. Pfeifer, K. Schubert, B. Kraushaar- Czarnetzki Th. Frank, D. Zhi Poster New process windows for the safe continuous perester synthesis of tert-butylperoxypivalate using micro process technology Miniaturized Combinatorial Synthesis Principles Numerical Investigations of Bubble Generation in Microreactors Universal Micro-reactors made of glass for applications to study the reaction kinetics 189 193 197 199