CURRICULUM VITAE/December, 2013 NAME KNIP, Jan Mikael DATE AND PLACE OF BIRTH September 28, 1950, Kvevlax, Finland CITIZENSHIP Finland CURRENT RESIDENCE EDUCATION AND TRAINING M.D., University of Oulu, Oulu, Finland M.Sc.D. (Ph.D.), University of Oulu, Oulu, Finland Title of doctoral dissertation: Endocrine pancreatic function and its regulation in infants and children in normal and pathological conditions Speciality in Pediatrics, National Board of Health,, Finland Subspeciality in Pediatric Endocrinology, National Board of Health,, Finland Special competence in diabetology, Finnish Medical Association Docent in Pediatrics, University of Oulu LINGUISTIC SKILLS Mother tongue Other languages: CURRENT POSITIONS Professor of Pediatrics, Children s Hospital, University of Chief Physician, Children s Hospital, University Central Hospital Project Director, Department of Pediatrics, Tampere University Hospital October 10, 1976 May 24, 1983 September 30, 1985 November 20, 1989 May 15, 1995 April 1, 1989 Swedish Finnish (excellent) English (excellent) August 1, 2000August 1, 2000June 1, 2001- ESSENTIAL PREVIOUS PROFESSIONAL AND RESEARCH EXPERIENCE Research Associate, Medical Research Council, Academy of Finland, 1979-83 total 52 months House Officer, Department of Pediatrics, Oulu University Hospital, 1983-86 total 36months Postdoctoral Research Fellow, Division of Endocrinology, Research 1986-87 Institute of the Hospital for Sick Children, Toronto, Ontario, Canada, total 16 months Lecturer in Pediatrics, University of Oulu, total 22 months 1988 Secretary General/Scientist, Nordic Council for Arctic Medical Research, 1990-95 total 60 months Senior Scientist s Career Grant, Medical Research Council, Academy of 1995-96 Finland, Acting Professor of Pediatrics, Medical School, University of Tampere, 1996-97 Senior Scientist, Medical Research Council, Academy of Finland; 1997-98 Professor of Pediatrics, Medical School, University of Tampere, 1998-2000 total 24 months Chair, Children s Hospital, University of, total 19 months 2001-2011 total 91 months Senior Scientist, Medical Research Council, Academy of Finland; 2002-2003 Dean, National Graduate School of Clinical Investigation, total 61 months 2003-2008 MAJOR RESEARCH FUNDING OVER THE LAST 5 YEARS Medical Research Council, Academy of Finland - Nutritional prevention of childhood type 1 diabetes, 93,750 - Multidisciplinary approach for the control of gene-environment interactions causing allergy epidemic, 140,510 2008-2009 2009-2012 1
- Nutritional prevention of childhood type 1 diabetes, 400,000 2010-2013 - Center of Excellence (CoE) for Molecular Systems Immunology 2012-2017 and Physiology, 360,000/year Tampere University Hospital - Prediction and prevention of type 1 diabetes, approximately 2008-60,000/year University Central Hospital - Pathogenesis of type 1 diabetes: From genetic susceptibility to clinical 2008-2009 disease and its prevention, 60,000/year -Pathogenesis of type 1 diabetes: From genetic susceptibility to clinical 2010-2012 disease and its prevention, 60,000/year - Pathogenesis of type 1 diabetes: From genetic susceptibility to clinical 2013-2015 disease and its prevention, 38,300/year Novo Nordisk Foundation - Molecular pathogenesis of type 1 diabetes: From genetic susceptibility 2008-2011 to clinical disease, 30,000-40,000/year Juvenile Diabetes Research Foundation (JDRF) - Characterization of beta-cell autoimmunity in preclinical type 2006-2009 1 diabetes, USD 165,000/year - Validation of a metabolic signature protecting against type 1 diabetes, 2013-2014 USD 110,000 Sigrid Juselius Foundation - Characterization of beta-cell autoimmunity in preclinical type 2008-2014 1 diabetes, 80,000/year National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) - Early dietary intervention and later signs of beta-cell autoimmunity: 2012-2015 Potential mechanisms, USD 1,851,860 National Institute of Child Health and Human Development (NICHD) - Trial to reduce IDDM in the genetically at risk (TRIGR), USD 2008-2016 2,200,000/year EU, 7 th Framework - Pathogenesis of type 1 diabetes: Testing the hygiene hypothesis 2008-2014 (DIABIMMUNE), 5,999,901 - Persistent virus infection as a cause of pathogenic inflammation in type 1 2011-2015 diabetes (PEVNET), 362,400 MERITS IN TEACHING AND PEDAGOGICAL COMPETENCE - Responsible for the undergraduate course in pediatrics, University of 2010- - Responsible for the specialist training in pediatrics, University of 2008-2010 - - Dean, National Graduate School of Clinical Investigation, total 61 months 2003-2008 - Responsible for the undergraduate course in pediatrics, University of 1998-2000 Tampere - Responsible for the specialist training in pediatrics, University of 2008-2010 - Tampere 1998-2000 - Pedagogic course in problem-based learning, University of Tampere 1996 Doctoral dissertations Supervisor for completed doctoral dissertations - Jukka Karjalainen, University of Oulu (together with Hans K. Åkerblom) 1989 - Päivi Tapanainen, University of Oulu 1989 - Outi Nuutinen, Universities of Kuopio and Oulu (together with 1992 Matti Uusitupa) - Kimmo Talvensaari, University of Oulu (together with Marjatta Lanning) 1995 - Paula Vähäsalo, University of Oulu 1996 - Riitta Veijola, University of Oulu (together with Jorma Ilonen) 1996 - Tuija Löppönen, University of Oulu 1997 - Johanna Rättyä, University of Oulu (together with Jouko Isojärvi) 2000 - Jorma Komulainen, University of Kuopio (together with Hans K. 2000 Åkerblom) - Emad Sabbah, University of Oulu 2000 - Petri Kulmala, University of Oulu 2000 2
- Kaisa Savola, University of Oulu 2000 - Anu-Maaria Hämäläinen, University of Oulu 2001 - Teija Kimpimäki, University of Tampere 2002 - Päivi Riihimaa, University of Oulu (together with Päivi Tapanainen) 2003 - Anna Toivonen, University of Tampere 2005 - Sanna Hoppu, University of Tampere 2005 - Matti Ronkainen, University of Oulu 2005 - Virpi Pylvänen, University of Oulu (together with Jouko Isojärvi) 2005 - Samy Mrena, University of 2005 - Marika Kukko, University of Tampere (together with Päivi Keskinen) 2005 - Liisa Uusitalo, University of Tampere (together with Suvi Virtanen) 2009 - Anita Kondrashova, University of Tampere (together with Heikki Hyöty) 2009 - Heli Siljander, University of 2010 - Janne Nieminen, University of (together with Outi Vaarala) 2013 Supervisor for doctoral dissertations under preparation - Susanna Aspholm, University of - Anne Hekkala, University of Oulu (together with Riitta Veijola) - Eeva Jason, University of Tampere - Anna Parkkola, University of - Petra Pöllänen, University of - Kirsi Salonen, University of RESEARCH AWARDS AND HONORS Scholarship from the Medical Research Council of Canada 1986-87 Dissertation Award, Alma and K.A. Snellman Foundation, Oulu, Finland 1987 Knud Lundbaek Award, Scandinavian Society for the Study of Diabetes 1999 Maud Kuistila Award for Scientific Achievement 2004 The Medica Award for high quality and clinically important research 2006 within the field of pediatric internal medicine, Finska Läkaresällskapet Novo Nordisk Lecture, Scandinavian Society for the Study of Diabetes 2006 Research Award, European Society for Paediatric Endocrinology (ESPE) 2006 The Johnny Ludvigsson Award, the Swedish Child Diabetes Foundation 2010 Honorary Doctor, Medical Faculty, University of Tartu 2012 OTHER ACADEMIC AND PROFESSIONAL ACTIVITIES Pre-examiner of doctoral dissertations - Anna-Maija Haavisto, University of Turku 1996 - Raija Anttila, University of 1996 - Samu Sarna, University of 1997 - Elina Hermanson, University of Helsnki 1998 - Kaisa Karjalainen, University of Oulu 2000 - Taina Härkönen, University of 2002 - Eeva Löflund, University of Oulu 2007 - Sini Laakso, University of k 2012 Opponent for doctoral dissertations - Ritva Sorri, University of 1989 - Outi Mäkitie, University of 1992 - Ekaterine Bakhtadze, Lund University, Sweden 2009 - Marit Bjørnvold, University of Oslo, Norway 2009 - Ilse Vermeulen, Free University Brussels, Belgium 2012 Reviewer of docent application - Leo Dunkel, University of 1990 - Annelie Carlsson, Lund University, Sweden 2009 Reviewer of guest professor application - Stefano Cianfarani, Karolinska Institute 2012 Activities in scientific societies Scandinavian Society for the Study of Diabetes (SSSD) 1979- - Member of the Board, President (1995) 1990-97 European Association for the Study of Diabetes (EASD) 1989- - Council Member 2000-2003 International Society for Pediatric and Adolescent Diabetes (ISPAD) 1990- - Member, Advisory Council 1999-2002 Immunology Diabetes Society (IDS) 1996-3
- Treasurer 2001-2005 Finnish Diabetes Research Society 1990- - Member of the Board 1990-95 Finnish Society of Sciences and Letters, member 1999- Other scientific activities European Nicotinamide Diabetes Intervention Trial (ENDIT) 1992-2003 - Deputy Coordinator 1992-2003 Medical Advisory Board, Finnish Diabetes Association - Member 1990- - Vice-Chairman 1993-94 - Chairman 1994-97 Scientific Committee, European Society for the Study of Diabetes - 31 st Annual Meeting, Stockholm 1995-32 nd Annual Meeting, Vienna 1996-42 nd Annual Meeting, Copenhagen 2006 Scientific Program Committee, 16 th International Diabetes Federation Congress,, Finland, July 20-25, 1997 - Vice-Chairman 1993-97 Biomed 2 - Scientific evaluator 1995 JDRF Medical Science Review Committee - Member 2005-2008 Research Council, University of - Member 2004-2006 Research Council, Faculty of Medicine, University of - Member 2004-2006 Diabetes Prediction and Prevention Study (DIPP) - Principal Investigator (PI), one of three PIs 1994- Trial to Reduce IDDM in the Genetically at Risk (TRIGR) - Deputy PI 2001-2008 - PI 2008- Finnish Pediatric Diabetes Register and Biobank - PI 2002- The Environmental Determinants of Diabetes in the Young (TEDDY) - Local PI 2004- Research Council for Health, Academy of Finland - Member 2007-2009 - Vice Chair 2010-2012 DIAMAP Road Map for Diabetes Research in Europe, Focused Sub-Group on Genetics and Epidemiology - Member 2008-2010 DIABIMMUNE Collaborative Project - PI 2008-2013 Data Safety Monitoring Board (DSMB), European and North American Trials with the diabetes vaccine Diamyd - Member 2008- Finnish Centre of Excellence in in Molecular Systems Immunology and Physiology Research - Deputy Director 2012- Novo Nordisk Foundation - Member of Nordisk forskningskomite 2012- Diabetes and Obesity Research Program, Medical Faculty, University of - Director 2013- Editorial Board membership Arctic Medical Research, Managing Editor 1990-95 International Growth Monitor, Review Editor 1990-2005 European Journal of Endocrinology, Editor 2000-2008 Journal of Clinical Endocrinology and Metabolism, Editorial Board 2005-2008 Member Pediatric Diabetes, Editorial Board Member 2001- Lancet Diabetes & Endocrinology, Editorial Board Member 2013-4
Referee for scientific journals Acta Paediatrica, Autoimmunity, British Medical Journal, Clinical Endocrinology, Diabetes, Diabetes Care, Diabetes/Metabolism Research and Reviews, Diabetic Medicine, Diabetologia, European Journal of Clinical Investigation, European Journal of Clinical Nutrition, European Journal of Endocrinology, European Journal of Pediatrics, FASEB Journal, Human Immunology, Journal of the American Medical Association (JAMA), Journal of Clinical Endocrinology and Metabolism, Journal of Clinical Investigation, Journal of Pediatrics, Lancet, Nature Reviews Endocrinology, Pediatric Diabetes, Pediatric Research, Pediatrics, PLoS One, Trends in Molecular Medicine SCIENTIFIC AND SOCIAL IMPACT OF RESEARCH Publications 490 original papers, 34 manuscripts, 72 reviews and editorials, 71 other publications, and 509 abstracts (please see separate list) H-index: 63 Citations: 14,734 Patents or patent applications Hyöty M, Knip M. Prevention of type 1 diabetes and other non-polio enterovirus diseases. European patent 1187631 706.9 2402 Viskari H, Knip M, Seiskari T, Hyöty H, Kummola L, Kondrashova A. Prevention of allergic sensitization. PCT WO2008/092996 Hyöty H, Knip M, Laitinen O, Tolonen O, Pulkki M, Oikarinen S, Honkanen H-R, Lecouturier V, Almond J. Enterovirus vaccines for preventing or treating type 1 diabetes (I). European patent application 10305714.7 Hyöty H, Knip M, Laitinen O, Tolonen O, Pulkki M, Oikarinen S, Honkanen H-R, Lecouturier V, Almond J. Diagnostic assay for type 1 diabetes. PCT application PCT/EP2011/061001 Spin-off company Vactech Ltd, aims at developing picornavirus vaccines, an antidiabetogenic enterovirus vaccine,in particular - Board member 2008- POSITIONS OF TRUST IN SOCIETY AND OTHER SOCIAL MERITS - Vasa nation, Inspector 2006- - The Association of Friends of the University Children's Hospitals, 2010- board member - UNICEF Finland, board member 2011-5