NEW TRENDS IN PAIN RESEARCH From Basic Research to Clinical Translation



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NEW TRENDS IN PAIN RESEARCH From Basic Research to Clinical Translation Panta Rei Hotel (www.hotelpantarei.com) Parghelia (VV), Calabria, Italy 13th-15th September, 2012 WITH THE SUPPORT OF THE PRESIDENT OF THE ITALIAN REPUBLIC UNDER THE AUSPICES The Italian Ministry of Health (www.salute.gov.it) The National Institute of Health (www.iss.it) The Italian Society of Neuroscience (www.sins.it) The Italian Society of Pharmacology (www.sifweb.org) The Japanese Society of Pharmacology (society@pharmacol.or.jp)

A COLLABORATIVE SCIENTIFIC INITIATIVE OF The Tohoku Pharmaceutical University Department of Physiology and Anatomy The University of Calabria Department of Pharmacobiology The University Magna Graecia of Catanzaro Department of Health Sciences The University Consortium for Adaptive Disorders and Headache (UCADH) Headache Science Center, The IRCCS Mondino Foundation PAVIA

ROME The IRCCS Santa Lucia Foundation/CERC PRESIDENTS Giacinto Bagetta (Cosenza) Maria Tiziana Corasaniti (Catanzaro) Shinobu Sakurada (Sendai) Cristina Tassorelli (Pavia) INTERNATIONAL ORGANIZING COMMITTEE Giacinto Bagetta (Italy) Carlo Caltagirone (Italy) Maria Tiziana Corasaniti (Italy) Oliver J. Dolly (Ireland) Stephen P Hunt (UK) Shinobu Sakurada (Japan) Giorgio Sandrini (Italy) INTERNATIONAL SCIENTIFIC BOARD Maria Pia Abbracchio (Milan)

Bruno Amantea (Catanzaro) Sebastiano Andò (Cosenza) Lucio Annunziato (Naples) Fabio Blandini (Pavia) Norman G. Bowery (Birmingham) Gianfranco Di Renzo (Naples) Stephen P. Hunt (London) Rosario Iannacchero (Catanzaro) Shiro Kishioka (Wakayama) Marcello Maggiolini (Cosenza) Sabatino Maione (Naples) Giuseppe Micieli (Pavia) Hirokazu Mizoguchi (Sendai) Luigi A. Morrone (Cosenza) Iroshi Nagase (Tokyo) Giuseppe Nappi (Pavia) Lucia Negri (Rome) Pierluigi Nicotera (Bonn) Domenicantonio Rotiroti (Catanzaro) Paola Sacerdote (Milan) Tsukasa Sakurada (Fukuoka) Diego Sisci (Cosenza)

Gianfranco Spalletta (Rome) Chizuko Watanabe (Sendai) John N. Wood (London) Akihiko Yonezawa (Sendai) LOCAL SCIENTIFIC COMMITTEE Annagrazia Adornetto (Cosenza) Diana Amantea (Cosenza) Laura Berliocchi (Catanzaro) Maria Cristina Caroleo (Cosenza) Laura Rombolà (Cosenza) Rossella Russo (Cosenza) EXECUTIVE COMMITTEE Michelangelo Certo (Cosenza) Federica Cavaliere (Cosenza) Antonella Ciociaro (Catanzaro) Maria Maiarù (Catanzaro) Francesco Petrelli (Cosenza) Damiana Scuteri (Cosenza) Giuseppe Varano (Catanzaro) SCIENTIFIC SECRETARIAT

Laura Berliocchi BSc, PhD, Department of Health Sciences, University Campus Salvatore Venuta University Magna Graecia of Catanzaro 88100 Catanzaro Tel 39 0961 369 4109 Email: Berliocchi@unicz.it EXECUTIVE SECRETARIAT Mr. Nicola Fico Department of Pharmaceutical Sciences, University of Calabria, Via Pietro Bucci, 87036 Rende (Cosenza) Italy Tel 39 0984 493248; Fax 39 0984 493462 Email: fico@unical.it SPONSORS Calabria Region University of Calabria, Rende (Cosenza) University Magna Graecia, Catanzaro Department of Pharmacobiology, Rende, (Cosenza) Pharmacists Association MEETING VENUE

Panta Rei Hotel (tel. 39 0963 600000) is located at Parghelia (Vibo Valentia), in one of the loveliest spots of the Tirrenian Coast facing the still active Stromboli volcano. The international airport of Lamezia Terme (Catanzaro) is 30 Km from the Hotel. Further travelling information are available on the web at www.pantarei.com. A reduced price has been agreed for the full board accommodation of participants to the workshop. LANGUAGE The official language of the conference is English. ABSTRACTS SUBMISSION Participants are welcome to submit abstracts for presentation at the meeting in the form of poster communications to be held in the afternoon session of the 14 th september. The abstract should be written according to the instructions given below. Deadline for submission: 15th July 2012. Abstracts must be submitted by e-mail to the secretariat (fico@unical.it), indicating Pain meeting as subject of the correspondence. Authors will be notified the acceptance of the abstract by August, 10th, 2012. Each abstract, written in times new roman (12 character), should contain a sentence stating the study objective; a brief statement of methods, if pertinent; a summary of the results and a statement of the conclusions. It is not satisfactory to say the results will be discussed. Use a short, specific title. Capitalize initial letters of trade names. Use standard abbreviations for units of measure. Other abbreviations

should be spelled out in full at first mention, followed by the abbreviation in parentheses. Include the source of research support on the bottom line of the abstract. The presenting author assures the merit of the presentation and that all authors listed have had a significant role in the research being reported. The size of the poster will be 70 cm width and 100 cm height. Posters should be mounted on the numbered boards at the corresponding number as listed in the book of abstract (e.g. P1 to P10) and should be attended by one of the Authors during the whole duration of the poster session; the relative information will be communicated by the scientific secretariat via the letter of acceptance. Posters should be dismounted at the end of the poster session. A selected number of presentations will be incorporated in the proceedings of the meeting and these will appear in an indexed Journal linked to Pubmed, ensuring that articles can be cited on Medline. Instructions to Authors will be available at http://gbagetta.jimdo.com as soon as possible. REGISTRATION FEE A registration fee of 350 must be payed at the time of abstract submission. The fee includes access to the meeting room, congress kit, cocktail at the opening ceremony, coffee breaks. Payment should be made to New Trends in Pain Research, Department of Pharmacobiology, University of Calabria, Via P. Bucci, 87036 Rende (CS) Italy. Bank details: MONTE DEI PASCHI DI SIENA FILIALE 8473, Via Ponte Pietro Bucci, 87036 Arcavacata di Rende (Cosenza). Cin W, ABI 01030, CAB

80880, Bank Account 000000010947, IBAN IT 52W 01030 80880 000000010947; BIC PASCITMMXXX. Further administrative information can be obtained from Dr Daniela Marsili (tel. 39 0984 493219; email: dmarsili@unical.it). A number of bursaries for young scientists are made available by the Italian Society of Pharmacology and by The Italian Society of Neuroscience. These will be attributed on a competitive basis; to this end, the participants should follow the instructions available upon request to the Societies or at http://gbagetta.jimdo.com.

SCIENTIFIC PROGRAMME Thursday, 13th September 18.00 Welcome address 18.15 Invited Opening Lecture Chairperson: Giacinto Bagetta (Cosenza) Invited Speaker: Hiroshi Nagase (Tokyo), Translational Research in Itching: Research and Development of nalfurafine hydrochloride and its application to kidney dialysis patients with intractable pruritus Friday, 14th September Morning session 9.00-10.30 MECHANISMS OF PAIN TRANSMISSION Chairpersons: Shinobu Sakurada (Sendai), Cristina Tassorelli (Pavia) 9.00-09.30 Stephen P Hunt (London), Pain mechanisms and new targets 9.30-10.00 Sabatino Maione (Naples), Transient receptors in pain transmission 10.00-10.30 Marzia Malcangio (London) Neuron-glia interactions in chronic pain 10.30-11.00 Coffee Break

11.00-13.30 CELLULAR AND MOLECULAR ASPECTS OF PAIN Chairpersons:, Oliver J Dolly (Dublin), Giorgio Sandrini (Pavia) 11.00-11.30 Laura Berliocchi (Catanzaro), Autophagy in neuropathic pain 11.30-12.00 Shiroh Kishioka (Wakayama), Novel mediators of peripheral sensitization 12.00-12.30 Lucia Negri (Rome), New trends in prokinetins research 12.30-13.00 Paola Sacerdote (Milan) Stem cells as advanced therapy of chronic pain 13.00-13-30 General Discussion Lunch Break Afternoon session 16.30-18.30 Free poster communications Chairperson: Laura Berliocchi (Cosenza), Cristina Tassorelli (Pavia) Saturday, 15th September Morning session 9.00-10.30 RATIONAL BASIS FOR PAIN TREATMENT Chairpersons: Carlo Caltagirone (Rome), Pierluigi Nicotera (Bonn), 9.00-9.30 Stefania Ceruti (Milan), Nucleotide receptors in trigeminal satellite glial cells: new targets for the pharmacological control of migraine pain

9.30-10.00 Santina Chiechio (Catania), Metabotropic glutamate receptors as target for chronic pain control 10.00-10.30 Tsukasa Sakurada (Fukuoka), Natural products for pain control 10.30-11.00 Coffee Break 11.00-13.00 ADVANCED PAIN THERAPY Chairpersons: Lucia Negri (Italy), Shiroh Kishioka (Japan), 11.00-11.30 Gianfranco Spalletta (Rome) Pain and depression 11.30-12.00 Shinobu Sakurada (Sendai), Involvement of H1 receptor in pain related behaviors induced by nociceptin and its metabolites in the mouse spinal cord 12..00-12.30 Cristina Tassorelli (Pavia), Endocannabinoids and migraineous pain 12.30-13.00 Oliver J Dolly (Dublin), Targeting SNARE for migraine control 13.00-13.30 General Discussion Lunch Break 15.00-17.00 ALCMEONE CONSORTIUM SYMPOSIUM ON PAIN* Chairspersons: A. Orlando R. Iannacchero 15.00-15.10 A. Orlando (Catanzaro) General Director, Health Department, Calabria Region - Introduction Ore 15.10-15.40 M. De Tommaso (Bari) New neurophysiopathologic evidence underlying chronic pain of central origin 15.40-16.00 R. Iannacchero & A. Iaria (Regional Health Service, Catanzaro)

Organizational strategies for diagnostic and therapeutic protocols for headache and neuropathic pain in Calabria: headache and cranial and peripheral nerve Day Service 16.00-16.20 F. Brighina (Palermo) Transcranic neuromodulation: headache and chronic pain of central origin 16.20 Discussion (*to be held in italian language)