Big Data Tom Plunkett Senior Consultant
2 Copyright 2013, Oracle and/or its affiliates. All rights reserved.
Big Data in Healthcare Find relationship between gene to cancer interaction Use Case Cross-referenced the relationships between 17000 genes and five major cancer types across 20 million medical publication abstracts Cross-referenced genes from 60Million patients and mirna for a simulated 900Million population. Understanding additional layers of the pathways these genes operate in and the drugs that target them is expected to help researchers in their work 2012 Government Big Data Solution 3 Copyright 2013, Oracle and/or its affiliates. All rights reserved.
Meet the Team Subject Matter Experts Technology Experts 2013 Oracle Corporation Shared with Partners under OPN NDA as Company Confidential: http://solutions.oracle.com/opn_esrc/partners/agreements/opp_agreement/opn_standard.pdf
Data Sources 2013 Oracle Corporation Shared with Partners under OPN NDA as Company Confidential: http://solutions.oracle.com/opn_esrc/partners/agreements/opp_agreement/opn_standard.pdf
Why Is This Problem Big? Multi-structured Data Scaling In All Dimensions Multiple Data Sources: Genes, mirna, PubMed, Lexicons Each Source Has A Different Data Structure ~20,000 genes per person. Each set is unique. Gene Sequencing Is Getting Cheap From $3.8B in 2006 to $5K in 2011. $1K is almost upon us. ~300M citizens in US. ~800M in Europe. $30B in NIH s Research Grants per year - NIH is adding 60,000 new articles a month. Cancer has a complex, growing, multi-lingual lexicon/thesaurus. 2013 Oracle Corporation Shared with Partners under OPN NDA as Company Confidential: http://solutions.oracle.com/opn_esrc/partners/agreements/opp_agreement/opn_standard.pdf
The Language Of A Subject Matter Expert Given an input set of microarray expression (or mirna expression) data: Identify a differentially-expressed gene list of a subset of samples against a very large set of background samples Annotate those genes within an existing set of internal databases Identify gene to disease and gene to drug interactions from the medical literature. Dynamically produce the literature based network of cancer to gene linkages Graphically represent the gene to drug, gene to gene and gene to disease networks identified. 2013 Oracle Corporation Shared with Partners under OPN NDA as Company Confidential: http://solutions.oracle.com/opn_esrc/partners/agreements/opp_agreement/opn_standard.pdf
What does this mean in English? Given a human s gene sequence: Isolate those genes associated with a cancer Correlate that gene to known cancer types via NIH publications that reference this gene and cancer type in the same article/abstract Present the information graphically. 2013 Oracle Corporation Shared with Partners under OPN NDA as Company Confidential: http://solutions.oracle.com/opn_esrc/partners/agreements/opp_agreement/opn_standard.pdf
The Language Of A Data Analyst 2013 Oracle Corporation Shared with Partners under OPN NDA as Company Confidential: http://solutions.oracle.com/opn_esrc/partners/agreements/opp_agreement/opn_standard.pdf
NCI Gene/Cancer Co-Occurrence 2013 Oracle Corporation Shared with Partners under OPN NDA as Company Confidential: http://solutions.oracle.com/opn_esrc/partners/agreements/opp_agreement/opn_standard.pdf
NCI Cancer Co-Occurrence 2013 Oracle Corporation Shared with Partners under OPN NDA as Company Confidential: http://solutions.oracle.com/opn_esrc/partners/agreements/opp_agreement/opn_standard.pdf
In May 2012, Chicago hosted the NATO Summit
Citizens Strife Both on the Streets and Online
Use Case We Developed a Social Media Analytics Solution To Help Monitor and Identify Potential Threats Analysis of public sentiment surrounding the NATO summit in Chicago to detect terrorist activities being organized through social media Sentiment Analysis enabled for Facebook, Blog, Digg, Twitter, YouTube by content, by author/username 14 Copyright 2013, Oracle and/or its affiliates. All rights reserved.
Endeca Information Discovery Case Study 15 Copyright 2013, Oracle and/or its affiliates. All rights reserved.
End-to-End Data Analytics With a Simplified IT Architecture Big Data Appliance Exadata Endeca Information Discovery Exalytics Oracle Business Intelligence ACQUIRE ORGANIZE ANALYZE DECIDE 16 Copyright 2013, Oracle and/or its affiliates. All rights reserved.