IPMSC First Scientific Conference Daily Program February 6 th 2013 19:30 Welcome dinner at the NH Milano 2 Hotel February 7 th 2013 Meeting Venue: San Raffaele Congress Centre - Caravella Santa Maria Room 8.15 & 8.30 Hostess to walk attendees from the Walking direction and map NH Milano 2 Hotel to the San available at hotel front desk Raffaele Congress Centre 8.00 9.00 Shuttle bus from NH Milano 2 Hotel to San Raffaele Congress Centre 8.00 9.00 REGISTRATION 9.00 9.10 Welcome from Italian MS Society Mario A. Battaglia 9.10 9.30 A call for Action John Golding Timothy Coetzee 9.30 9.45 Welcome, introduction and aims Alan Thompson of the meeting 9.45-10.00 Ongoing initiatives in progressive MS Giancarlo Comi Session I Chairperson: Wolfgang Bruck 10.00-10.15 Target identification and Wolfgang Bruck repurposing in progressive MS 15
10.15 10.45 1 st Keynote speaker Genetic profile 10.45 11.15 2 st Keynote speaker Immunologic aspects of progressive MS Stephen Sawcer Sergio Baranzini Scott Zamvil Marco Salvetti 11.15-11.30 Coffee break 11.30 11.50 Study group II report Peter Goodfellow 11.50 12.20 General Discussion 12.20 12.30 Sum up of the Session I Wolfgang Bruck 12.30 13.30 Lunch Session II Chairperson: Anne Cross 13.30-13.35 Experimental models for improved Anne Cross understanding of progressive MS and preclinical evaluation of novel therapies 13.35-14.25 1 st Keynote speakers Clues from degenerative aspects of progressive MS pathology Clues from inflammatory aspects of progressive MS pathology Bruce Trapp Hans Lassmann 14.25-14.35 Discussion of pathology and pathophysiology of progression 14.35-15.05 2 st Keynote speaker Pitfalls and problems with animal models David Baker Marco Prinz 16
15.05-15.15 Discussion of the animal models 15.15-15.25 Study group I report Peter Stys 15.25-15.35 General discussion 15.35-15.45 Sum up of the Session II Anne Cross 15.45-16.00 Coffee break Session III Chairperson: Giancarlo Comi 16.00-16.15 Proof-of-concept clinical trial strategies Giancarlo Comi 16.15-16.45 1 st Keynote speaker Study design and biomarkers for disease modifying treatment phase II clinical trials 16.45-17.15 2 st Keynote speaker Phase II trial design: including single-arm multi-arm, adaptive Gavin Giovannoni Massimo Filippi Jeremy Chataway Jerry Wolinsky 17.15-17.35 Study Group III report Raj Kapoor 17.35-18.05 General Discussion 18.05-18.15 Sum up of the Session III Giancarlo Comi 18.00 18.30 Shuttle bus from San Raffaele Congress Centre to NH Milano 2 Hotel 19.30 20.15 Shuttle bus from NH Milano 2 Hotel to Ciborio Hall Walking instructions and map available at hotel front desk 20.00 Gala Dinner at Ciborio Hall OSR DIBIT 2 22.00-23.00 Shuttle bus from Ciborio Hall to NH Milano 2 Hotel 17
February 8 th 2013 Meeting Venue: San Raffaele Congress Centre - Caravella Santa Maria Room 8.15 & 8.30 Hostess to walk attendees from the Walking direction and map NH Milano 2 Hotel to the San available at hotel front desk Raffaele Congress Centre 8.00 9.00 Shuttle bus from NH Milano 2 Hotel to San Raffaele Congress Centre Session IV Chairperson: Chris Polman 9.00-9.15 Clinical outcome measures Chris Polman and phase III trial designs 9.15-9.45 1 st Keynote speaker Phase III trials of DMTs in progressive MS: Jeffrey Cohen endpoints and other aspects of trial design 9.45-10.15 2 st Keynote speaker Phase III trials in progressive MS: biomarkers of information, axonal damage demyelination and remyelination Ludwig Kappos Per Solberg Sorensen Robert Fox 10.15-10.35 Study group IV report Jeremy Hobart 10.35-10.45 General discussion 10.45-10.55 Sum up of the Session IV Chris Polman 10.55-11.10 Coffee break 18
Session V Chairperson: Alan Thompson 11.10-11.25 Symptom management therapies Alan Thompson and rehabilitation strategies 11.25 11.55 1 st Keynote speaker Congnitive rehabilitation and progressive MS 11.55-12.25 2 st Keynote speaker Exercise therapy and multiple sclerosis John De Luca Maria Pia Amato Ulrik Dalgas Chris Heesen 12.25-12.55 Study group V report Peter Feys 12.45-13.15 General discussion 13.15-13.25 Sum up of the Session V Alan Thompson 13.25-14.30 Lunch Session VI Chairperson: Monica Di Luca 14.30-15.45 Challenges that together we can Steve Buchsbaum address to bring new medicines Sarah Tabrizi to patients: non-profit, Paul Matthews academia and pharma views 15.45-16.15 Panel discussion Moderated by Heather Brown Steve Buchsbaum Sarah Tabrizi Paul Matthews 16.15 16.30 Coffee break 19
Session VII Moderator: Timothy Coetzee Facing progressive MS 16.30 17.00 Collaborative Progressive MS Research Alan Thompson Program: IPMSC proposal and Antonella Moretti next key actions 17.00 17.30 Open Forum with IPMSC Giancarlo Comi Scientific Leadership Anthony Feinstein Bob Fox Raj Kapoor Marco Salvetti Alan Thompson 17.30 17.45 Conclusion and perspective Weyman Johnson 17.45 18.15 Shuttle bus from San Raffaele Congress Centre to NH Milano 2 Hotel 20