AUTOCLAVABLE R&D FERMENTERS/ BIOREACTORS

AUTOCLAVABLE R&D FERMENTERS/ BIOREACTORS

JUPITER is designed as fermenter/bioreactor suitable for beginner and experience user alike. It is therefore ideal for educational purposes. JUPITER meets your specific needs, it covers a wide range of applications and complies with the requirements of a validated GMP regulation. The PCS includes all the functions for parameters measurement and control: intelligent sensors, wireless connection, easy load pumps and aeration module conveniently located. It is designed for greater performance at a lower operating cost for your lab. The best ratio Quality/ Capability/Price on the market JUPITER is an ideal partner for microbial fermentation as well as animal, plant and insect cell cultivation. Typical applications includes the following: Education Basic research Scale-up and scale-down studies Process development and optimization WHY TO INVEST IN THIS PRODUCT SCADA Software Leonardo, with parallel control: up to 24 vessels managed from one station JUPITER can be used for: Biopharmaceutical Biofuels research and manufacturing Vaccines Food and beverage biotechnologies Bioremediation Bioplastics Cosmeceutical Nutraceutical 12 different volumes and D/H ratio

Benefits Vessels series User-friendly fermentation and cultivation management Innovative PARALLEL process control Remote control for after sale assistance Remote access via PC, tablet/smatphone Parallel parametres calibration do 2 and ph cascade control Up to 4 integrated pumps capable of operating in variable speed mode and additional externals brushless pumps Automatic gas mixing algorithms for simplified controls (4-gas, 3-gas, O 2 enrichment, N 2 enrichment) VESSEL Solaris with 12 different volumes and 7 diameter/height ratios has probably the most various range of standard bioreactor/ fermenters on the market, giving its clients the flexibility needed to find the right solution for their application. Compact PCS (350x350x350 mm). 23 touch display. Safety: pressure releaf valve included with every unit. Powerful brushless motors, from 1 to 2000 RPM. Online absorbed Torques (Nm) and Power (W) measurements obtaining an indirect density indication of the culture broth. Fully removable and cleanable jacket. Up to 24 vessels managed with one station. Modbus Hamilton sensors: ph, do 2, conductivity, redox. Four assignable peristaltic pumps, all speed controlled. Sterile sampling systems. External plug & play additional sensors: OD, dco 2, turbidity, weight, peristaltic pumps. Gax mixing up to 5 TMFC (Air, CO 2,N 2,O 2 and overlay).

Leda sampling system Gas mixing Sterile single use sampling system up to 180 sterile sampling per batch. Needlefree connector is designed to reduce the risk of contamination during sampling. Flat Split-septum Straight fluid path Various controller and hardware configurations enable aeration strategies using air, oxygen, nitrogen or a mixture of these to enrich the air. The mass-flow controller allows the exact flow rate control of individual gases. The flexible aeration options integrated in the fermenter/bioreactor permit a wide range of different application giving to this system a substantial versatility. Technical specifications Material Autoclavable Residual volume Flow rate VALOX resin (external) silicone (internal) 121-133 C (up to 30 minutes) 0.04 ml 165 ml/minute Minimal deadspace Thermal Mass Flow Controller in entry model The sterile combination of a syringe (3-5-10-30 ml) and a non return valve guarantee the sterility after sampling until the next use. Gas mixing through TMFC and solenoid valves or numbers of TMFC Automatic gas mixing algorithms for simplified controls (4-gas, 3-gas, O 2 enrichment, N 2 enrichment) Toro, fluted and sintered spargers

S Cube Leonardo 2.0 SOLARIS CUBE SERIES Why a Cube? Solaris new modular product design strategy decreases time to market and the number of unique parts in the product architecture increasing the number of product variants. The result is a lean, flexible and smart PCS. USER-FRIENDLY SOFTWARE The software is the user s best friend in experimental design planning and performing trial runs, as well as analyzing and optimizing media and parameters for cultivation. The graphical user interface enables you to select the software functions intuitively. Data extracted are compatible with Window Excel. However, Solaris has developed a platform where to easily and quickly manage cultivation data. This software is included in the fermenter/bioreactor supply and can be installed on unlimited number of client s PC or laptop. WHAT COLOR SUITS YOU BEST? Do it parallel: smarter..faster Leonardo can be used for process development (i.e. time-saving parallel fermentation approaches) Up to 24 indipendent fermentations/cultivations can be carried out simultaneously. Parallel synoptic. Parallel trends comparison between units, current and old batches. Plug and Play modular additional parameters for future PCS upgrade including dco 2, Cell Density, Turbidity, weight, peristaltic pumps, ect. Do it wireless! Increased mobility: users can roam around lab or reaching office or home without losing their connection with the running batch.

Data sheet Vessel Solaris Code Jupiter 2.0 Jupiter 3.0 Jupiter 3.1 Jupiter 4.0 Jupiter 4.2 Jupiter 4.5 Jupiter 5.0 Jupiter 5.5 Jupiter 6.0 Jupiter 7.0 Jupiter 8.0 Jupiter 10.0 Production Code A1 B1 A2 A3 B2 C1 A4 B3 C2 B4 C3 C4 Total Volume (liters) 2,00 3,00 3,10 4,00 4,20 4,50 5,00 5,50 6,00 7,00 8,00 10,00 Ratio D/H 1:2,0 1:1,5 1:2,5 1:3,0 1:2,0 1:1,5 1:4,0 1:2,5 1:2,0 1:3,5 1:2,0 1:3,0 Min. Working Volume (liters) 0,33 0,40 0,46 0,46 0,72 0,44 0,46 0,72 0,87 0,62 0,87 0,96 Max. Working Volume (liters) 1,50 2,25 2,25 3,00 3,15 3,40 3,75 4,00 4,50 5,25 6,00 7,50 Max. temperature 0-135 C Operating pressure n. 13 Headplate Ports s lenght (mm) n.1 port, Gas Sparger Input n.1 port, Gas overlay n.1 port, Gas Out/Condenser n. 1 port, Sampling system n.1 port, Harvesting system < 0,5 bar n.1 port, Temperature n.1 port, Antifoam probe n.1 port, ph sensor n.1 port, do₂ sensor n.1 port, 4 sterile connections n.2 ports, double sterile connections n.3 port, spares (2 PG13.5 DN12,1 M16DN12) n.1 port, Agitation Group ph 225 225 325 325 325 225 425 325 325 425 325 425 do₂ 225 225 325 325 325 225 425 325 325 425 325 425 Dimensions for autoclave (with Condenser) Height (mm) 505 505 580 655 580 505 760 655 580 760 655 760 Diameter (mm 225 240 225 225 240 280 225 240 280 240 280 280 Design Materials Stirring Drive Power Impellers Thermoregulation Control Gas Control & Gas Mixing Sparger and overlay Gas Control Gas Mixing (Air,CO 2,O 2,N 2 ) Sparger type Exhaust Peristaltic Pumps Controller Master Controle Module Borosilicate Glass Jacketed Vessel Borosilicate Glass and AISI 316 L Brushless Motor, Direct Assembly, 1-2000 rpm (bacterial), 1-500 (cell cultures) 266 W Select from: Rushtons impellers, Marine Impellers, Pitched blade PID Control - Accuracy 0,1 C - Jacket water heater TMFC n.1 TMFC + n.4 solenoid valves, n of TMFC Select from: Toro type (ring), syntered microbubbling both provided with 0,2 µm filter Condenser and 0,2 µm filter up to 4 Watson Marlow 114, speed 0-60 rpm, volumetric flow 0,5-51 ml/min, application assignable from software n. 1 Watson Marlow 313 FDM/D, speed 45-350 rpm, volumetric flow 1,5-1750 ml/min, application assignable from software n. 1 Watson Marlow 520 FDM/R2, speed 45-230 rpm, volumetric flow 1,8-3450 ml/min, application assignable from software from 1 to 4 units - Dimensions Height: 350 mm Largeness: 350 mm Depth: 350 mm HMI with Leonardo software 9,7 Controls Temperature PT100 0-150 C ph Digital Hamilton sensor 0-14 Operation temperature 0-130 C 0-6 bar Actuator Cascade to peristlatic pumps for the addition of acid/base solutions or gas (CO 2 ) do 2 Digital Optical Hamilton sensor 0,05-300% air saturation Operation temperature -10-130 C Actuator dco 2 Operation temperature Turbidity Cell density Option 1 Option 2 Redox (ORP) Operation temperature Conductivity Operation temperature Weight Control Antifoam/Level Control 0-12 bar Cascade to RPM, Gas Control, feedings,ect Mettler Toledo sensor 0,00-200% saturation -20.0-150 C 0-4 bar Mettler Toledo sensor 0-250 g/l, 10-4000 FTU Hamilton-Fogale sensor Total cell density (Two ranges: 10^5 to 10^8 mammalian cells/ml - 0.5 to 300 g/l dry weight) Viable cell density (Two ranges: 5x10^5 to 8x10^8 mammalian cells/ml - 5 to 200 g/l dry weight) Digital Hamilton sensor ±2000 mv - 10-130 C 6 bar Digital Hamilton sensor 1-3000 µs/cm 0-130 C 0-20 bar n.3 load cells Solaris sensor Chiller Optionally JUPITER can be equipped with a chiller for heat removal from your culture minimizing lab water usage Using this system you don t need a water supply line in your lab Cost-effective cooling of fermenters Easy operation Refregerant level monitoring Chiller data sheet Working temperature range -25 C / +100 C Temperature stability ±0.05 Heating power Cooling output at 20 C Pump pressure max. Pump flow max. Bath volume Bath opening Bath depth SAVE WATER 1.5 kw 0.225 kw 0.2 bar 15 L/min. 5-7.5 L 165x190 mm 160 mm Cabinet height (mm) 605 Cabinet largeness (mm) 220

SOLARIS BIOTECHNOLOGY srl Via Bachelet, 58-46047 Porto Mantovano Mantova - Italy Phone: +39 0376 408760 Fax: +39 0376 385108 Email: info@solarisgroup.org www.solarisbiotech.com