An ARC and IACUC Guideline/Policy Large Animal Anesthesia and Analgesia Guidelines Common Agents for Sedation, Anesthesia, and Analgesia - NHPs Dexmedetomidine - sedation Dexmedetomidine anesthesia/intubation 0.5-2 mg/kg 2 mg/kg @ 100 mg/ml 75 mcg/kg @ 500 mcg/ml 3 mg/kg@ 100 mg/ml 75 mcg/kg@500 mcg/ml Re-dose Dex as needed at 18-54 mcg/kg 1-2% maintenance w/ket+dex 2-3% - maintenance Buprenorphine - analgesia 10-50 µg/kg (0.01-0.05 mg/kg), SC every 12 hrs. every 24 hours Approved by IACUC 4/23/2015 1 of 5
Common Agents for Sedation, Anesthesia, and Analgesia Rabbits Diazepam - sedation Diazepam -sedation Xylazine - anesthesia Xylazine + Acetylpromazine anesthesia Pentobarbital anesthesia/acute procedures 0.75-1 mg/kg, SC 0.5-1.0 mg/kg Max 20 mg (4ml) 20-40 mg/kg 1-5 mg/kg SC, 10-40 mg/kg 3-5 mg/kg Re-dose at 1/3 the original dose of Ketamine only 30-40 mg/kg 5-7.5 mg/kg 0.75-1 mg/kg 30-45 mg/kg IV Buprenorphine - analgesia 10-50 µg/kg (0.01-0.05 mg/kg), SC, IV every 6-12 hrs. Ketoprofen - analgesia 1-2 mg/kg SC, PO, every 24 hrs. Carprofen - analgesia 4 mg/kg PO 1-2 mg/kg SC Every 12 hrs. PO- every 24 hrs. SC - every 12 hrs. Meloxicam - analgesia 0.1-0.5 mg/kg PO, SC - every 12-24 hrs. Yohimbine reversal agent 1-3 mg/kg, IV 2 of 5
Common Agents for Sedation, Anesthesia, and Analgesia Pigs Acetylpromazine - sedation 0.11-0.22 mg/kg Midazolam + Butorphanol + Xylazine sedation Telazol (tiletamine/zolazopam)+ Xylazine - sedation Telazol (tiletamine/zolazopam)+ Xylazine + Atropine - anesthesia Xylazine -anesthesia 0.3-0.4 mg/kg 0.3-0.4 mg/kg 2.2 mg/kg 4.4 mg/kg 1.1 mg/kg 4.4-6.6 mg/kg 2.2 mg/kg 0.05 mg/kg 20 mg/kg 2 mg/kg Buprenorphine - analgesia 10-50 µg/kg (0.01-0.05 mg/kg), SC every 12 hrs. - every 24 hrs. Carprofen - analgesia 2.2 (every 12 hrs.) 4.4 (every 24 hrs.) mg/kg SQ, PO (can use dog chewables) Atropine - anticholinergic 0.05 1 mg/kg Yohimbine reversal agent xylazine given 3 of 5
Common Agents for Sedation, Anesthesia, and Analgesia Dogs Diazepam - sedation Buprenorphine - sedation Buprenorphine - anesthesia Ketamine+ Diazepam anesthesia 0.05-0.5 mg/kg, SC, IV, PO 0.25-1.0 mg/kg Max 20 mg (4ml) 10 mg/kg @ 100 mg/ml 0.5 mg/kg @ 5 mg/ml IV, IV Mix in 1 syringe Buprenorphine - analgesia 10-50 µg/kg (0.01-0.05 mg/kg), SC every 12 hrs. - SID Carprofen - analgesia 2.2 mg/kg PO, SQ - SID 4 of 5
Common Agents for Sedation, Anesthesia, and Analgesia Cat 0.05-0.2 mg/kg Ketamine - sedation 2-5 mg/kg Buprenorphine - sedation Dexdormitor + Buprenorphine - anesthesia Ketamine+ Diazepam anesthesia Acetylpromazine - anesthesia 10 mg/kg @ 100 mg/ml 0.5 mg/kg @ 5 mg/ml 10 mg/kg 0.1 mg/kg IV Mix in 1 syringe Buprenorphine - analgesia 10-50 µg/kg (0.01-0.05 mg/kg), SC every 12 hrs. - every 24 hrs. 5 of 5