Symposium in Memory of Laurence Clarke: Moving Radiomics Forward: Funding, Regulatory Issues, and Clinical Translation AAPM 2016 Thank you to his family Larry s wife, Alice Clarke Larry s daughter Laura Clarke and Alisun Sfeir Laurence (Larry) P. Clarke, Ph.D. Dr. Clarke, Larry, was the Branch Chief of the Image Technology Development Branch of the Cancer Imaging Program at the NCI (National Cancer Institute) Larry passed away on April 16, 2016 after an impactful medical imaging career spanning almost 40 years. He was 72. He had been at NCI since 1999. 1
Laurence P. Clarke, Ph.D. Dr. Clarke received the Bachelor and Master degrees from Queens University in Belfast And earned his PhD in medical imaging physics at National University of Ireland in 1978, focusing on quantitative nuclear imaging. He started in academia at University of South Florida and the H. Lee Moffitt Cancer Center, and the University of Miami, and the Dublin Institute of Technology. He also served as an adjunct professor of engineering and bioengineering at George Washington University. Tribute to Larry Clarke, Ph.D. a Scientist, a Visionary, a Leader, a Colleague, & a Friend Leadership was profound Scientific contributions were substantial Efforts to bring scientists together successful Insights on the particular strengths of of an investigators was evident Humor was infectious Personality was genuine Tribute to Larry Clarke, Ph.D. Larry was a leader in medical imaging technology and championed the advancement of bringing quantitative imaging into clinical trials. Focused on making medical imaging a more quantitative and reproducible science. Embraced and advocated for the broader imaging research landscape of open science, consensus building, and collegiality. Built bridges across academia, industry, and government to translate research findings into practice. 2
First met Larry through CAD research in Breast Cancers on Mammograms First met Larry through CAD research in Breast Cancers on Mammograms Laurence P. Clarke, Ph.D. Dr. Clarke was a visionary in the field of cancer imaging with a particular focus on quantitative imaging methods across a range of imaging modalities to support clinical decision-making and cancer research. He established several NCI programs and research networks for the development and validation of quantitative imaging methods for current and next-generation imaging platforms that support multi-center clinical trials and preclinical research. Recall that he moved to NCI in 1999. 3
Development of large public databases LIDC: Lung Imaging Database Consortium RIDER: Reference Image Database for Evaluation of Response IDRI: Image Database Resource Inititative Development of large public databases LIDC: Lung Imaging Database Consortium RIDER: Reference Image Database for Evaluation of Response 2011 51 institutions 4
Development of open-source informatics tools and imaging archives Efforts as a co-chair of the Trans NCI-Center for Biomedical Informatics & Information Technology (CBIIT) informatics working group stimulated the development of open-source informatics tools and imaging archives that permit the evaluation of clinical decision tools as applied to cancer and precision medicine. Development of QIN QIN: Quantitative Imaging Network 20 people at a 2007 QIN presentation at AAPM Then in 2015, QIN has 300 investigators The network is designed to promote research and development of quantitative imaging methods for the measurement of tumor response to therapies in clinical trial settings, with the overall goal of facilitating clinical decision making. QIN Network Goals Development and Performance Assessment of QI Methods for Data Collection and Analysis QIN Data From a Clinical Trial Development Annotated image databases with metadata & outcomes Clinical trial Tool Validation Compare Data & Results 15 5
Development of QIN Challenges in Quantitative Imaging Subtle but major difference in goal of a Challenge Not just technical goal of an algorithm but a clinical goal LUNGx Challenge 2015 LUNGx Challenge panel discussion Co-Clinical Trials & Imaging Again bringing folks together. WMIS has collaborated with NCI program staff to initiate interest in promoting best practices for co-clinical trials. 6
Tribute to Larry Clarke, Ph.D. We miss Larry greatly - he was so enthusiastic, visionary, and effective, and really moved imaging forward in today s science of precision medicine. The halls at this AAPM meeting are missing his motivating voice and enthusiastic laugh Larry & AAPM The halls at this AAPM meeting are missing his motivating voice and enthusiastic laugh. Larry & AAPM 7
Larry & AAPM History Interview by Lawrence Rothenberg (2010) Virtual Library Presentations 2005 Role of Imaging in Drug Response: Challenges and Opportunities 2006 Molecular Imaging II Applications 2007 Current NIH and NCI Initiatives using Imaging Biomarkers 2009 NCI: Quantitative Imaging Initiatives and Public Resources for Standardized Data Analysis 2010 NCI Initiatives on Translational Research: An Overview of Opportunities 2014 NCI QI Initiatives: Past, Present, and Future 2015 NCI Interest in Promoting Best Practices for Co-Clinical Trials 2016 was to speak on Funding for Radiomics Larry at AAPM s Radiomics FOREM Autumn 2014 Larry at RSNA & SPIE Medical Imaging 8
In 2010 -- AAPM s "Achievement in Medical Physics Award, now known as the Edith H. Quimby Lifetime Achievement Award Fellow of AAPM, SPIE, AIMBE Had a dramatic impact on the current state of quantitative medical imaging research around the world 9