Darlene Langhoff St. Thomas More High Ron Gerrits MSOE

Darlene Langhoff St. Thomas More High Ron Gerrits MSOE

Investigating the Scene DNA analysis The Findings

Crime scene is set up (optional power point ) Tip: Set up crime scene and have students take photos make your own power point Examine key information gathered from interviews of friends, family members, and people of interest, examine the scene for clues Stations set up to analyze the various clues Tip: Check for videos on fingerprint analysis, hair analysis, blood splatter analysis

Time of Death/ Experimental Design Process introduced Tip: Add Salt to get Drylock out of tubes Blood Spatter/Experimental Design practice

DNA structure introduced Simulation of DNA analysis and electrophoresis comparison of the DNA found at the crime scene with the DNA obtained from each of the suspects Tip: Have students make one large gel with all the DNA pieces

Autopsy activity See partial autopsy report, create a report detailing all of the evidence and draw conclusions as to the method of death Anna s Case File is started Tip: Students need more guidance with this. Tip: Present case report to police officer.

What is Diabetes The Science of Food Life with Diabetes

Begins with Anna s medical history age 14 Anna is diagnosed and the types of diabetes are explored using a lab activity Tip: Buy/make your own buffers for this lab don t buy kits

Insulin/ Glucose Receptor Model Tip: Video the presentations and post on the LMS assign peer review for homework Feedback Loops

Food testing, Anna s stomach contents tested to determine if that could have been related to her death Look at Anna s food diary Food label analysis and analysis of Anna s diet Tip: Post food labels on the LMS for the students for activity, use the same foods for labs

Basic chemistry Biomolecules with puzzle kits Calorimetry activity related back to Anna s diet Tip: Post video of the lab on LMS to save time on lab day

Make a guide for people recently diagnosed with diabetes Use these guides to compare type 1 and 2 Diabetes Diabetic Emergency match situation with simulated cell/serum

Design a medical intervention to help diabetics Research long and short term complications of Diabetes and make a Graphic Organizer Body showing complications

The Disease It s In The Genes Chromosomes Inheritance

Look at another part of Autopsy Report determine that Anna had Sickle Cell Compare normal blood and Anna s and complete a hematocrit to determine whether Anna s sickle cell disease was causing her other related health problems Tip: Allow time to test blood recipe to get desired results

Use Anna s diary to learn about life with sickle cell Write diary entries for another patient that includes treatments and career component Tip Video diary instead of written diary submit on the LMS, check for video examples

Transcription, translation and mutation activity Uses Anna s DNA to look at sickle cell mutation Looks at normal and mutated protein using Molecular Workbench Tip: Talk to Biology teachers this unit is a great opportunity to make connections Tip: Feeling like you are behind? May be able to move faster in this unit

Activity that covers chromosomes mitosis and meiosis simulation of inheritance Hela cells (optional, moving to MI)

Pedigree using electrophoresis data to make a pedigree of Anna s family Probability Optional sickle cell and malaria allele frequency activity

Heart Structure The Heart at work Heart Dysfunction Heart Intervention

Blood pathway heart box Heart dissection, comparison of artery and vein Tip: Post pictures of heart dissections for assessment and review Look at Anna s autopsy report Tip: Look over all activities with report before you start unit

Concentric left ventricular hypertrophy Evidence of mild mitral valve prolapse. A stent is present in the left anterior descending coronary artery; however, scar tissue and clots partially block or occlude the lumen of the vessel. The right coronary artery is 80% occluded. Narrowing is also noted in the renal arteries as well as the cerebral arteries and provides evidence of atherosclerosis. ACE inhibitors and Statins Evidence of mild peripheral vascular disease in the left leg. X-ray shows pacemaker

Anna s medical history with cardiac tests, blood work, EKG, Echocardiogram, Angiogram Heart Rate: write lab and relate to medical history Blood Pressure: take manually and with probes, write lab procedure and report, relate to medical history

EKG: Relate to medical history and research some of the doctor s findings Tip: Have students make videos demonstrating how to use equipment post to LMS include Logger Pro tips.

Cholesterol Make product that accurately informs high school / college students about cholesterol, LDL, and HDL Analyze Anna Garcia s cholesterol test results and make recommendations about her cardiac care

Hypercholesterolemia DNA electrophoresis to determine if Anna and members of her family have familial hypercholesterolemia Tip: Make video of procedure using your equipment post to LMS. I have my HBS students do this when they set up their lab.

Investigate medical procedures used to treat blocked blood vessels and build a model to demonstrate one technique Return to Anna s medical history documents and autopsy report and brainstorm how issues of the heart may have played a role in Anna s final demise

Build a Pump Design an experiment to determine the effect that narrowing vessels, as caused by cholesterol plaques, plays on flow rate

Assess risk of heart disease Calculate risk for both Anna Garcia and a patient you have been assigned Design a heart disease intervention plan for assigned patient Tip: Video a counseling session with client regarding intervention, post to LMS

Piece of Anna s medical history documenting an unknown illness bacterial illness a short time before death, need to identify the pathogen Demonstrate the transmission of infectious agent from person to person determine patient zero

Explore the different types of pathogens in order to identify what is plaguing Anna.

Basics of aseptic technique and to perform the first step in identifying bacteria isolating bacterial colonies Tip Check purchase manual carefully the kit is only media bacteria not included Gram stain Anna s bacteria Tip: Kit directions not the same as activity directions

Bacterial Identification of Anna s bacteria 15 biochemical test results used Tip: This was a lab in the field test, you can find videos of this test online to show the students

Children s book of immune response

How Do The Parts Make a Whole? Similar to previous activity but relates more to Anna and how her diseases impact body systems

One final autopsy report and put together all information to determine Anna s cause of death Think about the interventions or innovations that may have saved Anna that day Reflect on the power of prevention in keeping the body well and safe from harm

Keeps students from finding out from last year s students what the answer is. Instructor chooses which of the 4 final autopsy reports to provide. Students use the final report, along with previous course work to (hopefully) determine one of the following causes of death: Ischemic stroke, secondary to atherosclerosis Diabetic coma associated with diabetic ketoacidosis (DKA) Spontaneous splenic rupture caused from splenic infarction during a sickle cell crisis. Septicemia, associated with an untreated urinary tract infection, and a kidney infection

Final autopsy report indicates: Facial drooping. Severe atherosclerotic plaques in an artery in her neck. This fits in the course because Anna had a lot of problems, including: Hyperlipidemia Diabetes Each of these is a major risk factor for atherosclerotic strokes.

Final autopsy report indicates: Acidic blood (acidosis). Ketones in blood and urine. Brain swelling although this is much more common in children than adults and may be more a consequence of treatment than the disorder. This fits in the course because Anna has Type I diabetes.

Final autopsy report indicates: Anemia. Enlarged, bleeding spleen. This fits in the course because Anna had Sickle Cell Disease

Final autopsy report indicates: Elevated white cell count Positive blood culture Red streaks on the skin bacteria leaving the blood and creating localized infections. Inflammation of the urinary tract This fits in the course because Anna recently had a urinary tract infection.