Ministero della Salute

Ministero della Salute Direzione Generale Ricerca Sanitaria e Biomedica e della Vigilanza sugli Enti BANDO 2010 RICERCA FINALIZZATA GRADUATORIA PROGETTI ORDINARI 2314291 Role of circulating and tissutal markers of low grade chronic inflammation for defining the clinical phenotype of complicated obesity MAUGERI Endocrinology, Metabolism, Nutrition and Reproductive Sciences 4,5 400.000 2310494 mir 221&222/miR 126&126* interconnected networks: novel molecular markers and potential therapeutic values in melanoma. Istituto Superiore di Sanita' Oncology 1 Basic 4,5 365.500 2318823 Toward Chronic Lymphocytic Leukemia (CLL): dissecting the role of genetic lesions in Monoclonal B cell Lymphocytosis (MBL) through a genome wide sequencing approach Oncology 1 Basic 4,5 450.000 2309719 EMILIN1 in tumor microenvironment: role in neoplastic growth and lymphatic spread C.R.O. AVIANO Oncology 1 Basic 4,5 295.000 2316156 Immunotherapy with dendritic cells loaded with cancer stem like cells: a phase I study in glioblastoma CARLO BESTA Oncology 2 5 599.000 2313979 strategy for developing rationale combinations of molecularly targeted agents in primary refractory Hodgkin lymphoma Piemonte Oncology 2 5 550.000 2310888 TUMOR ASSOCIATED MACROPHAGES: NEW MARKERS FOR MOLECULAR TARGETING HUMANITAS Oncology 1 Basic 5 600.000 Pagina 1 di 142

2309484 STUDIES ON THE INVOLVEMENT OF GENETIC, EPIGENETIC AND ENVRINOMENTALFACTORS IN THE PATHOGENESIS OF CONGENITAL HYPOTHYROIDISM.NOVEL PERSPECTIVES FOR THE MANAGEMENT OF A LARGELY UNEXPLAINED DISORDER AUXOLOGICO Endocrinology, Metabolism, Nutrition and Reproductive Sciences 5 590.000 2312785 Therapeutic potential and safety assessment of induced dopaminergic neuronal (idan) cells directly reprogrammed from adult skin fibroblasts Molecular, Cellular, and Developmental 5 585.000 2318269 Exploiting immune cross reactivity to influenza viral antigens for successful pre pandemic vaccines. Istituto Superiore di Sanita' Immunology 5 579.700 2311657 Recovery of cholinergic neurotransmission dysfunction in DYT1 dystonia SANTA LUCIA Brain Disorders and 5 370.000 2312222 The role of hypoxia in regulating micrornas and target genes in cancer biology: identification of new therapeutic targets Istituto Superiore di Sanita' Oncology 1 Basic 5 522.500 2319050 Gene therapy for thalassemia: preclinical studies of efficacy and safety Genes, Genomes and Genetics 5 500.000 2310201 Plasma microrna profiling as first line screening test for lung cancer detection: a prospective study ISTITUTO TUMORI MILANO Oncology 2 5 390.000 2310538 Building a state of the art whole room indirect calorimeter, a tool to accurately investigate the role of energy expenditure and substrate oxidation in endocrine and metabolic disorders Toscana Endocrinology, Metabolism, Nutrition and Reproductive Sciences 5,25 600.000 2319722 Italian Network for autosomal dominant Alzheimer s disease and frontotemporal lobar degeneration FATEBENEFRATELLI Brain Disorders and 5,25 600.000 2318290 Volatile anesthetics to reduce mortality in cardiac surgery. A multicentre randomized controlled study. Surgical Sciences, Biomedical Imaging, and Bioengineering 5,5 600.000 2311584 Thrombolysis in Minor Stroke Emilia Romagna Brain Disorders and 5,5 500.000 Pagina 2 di 142

2308451 The Renal Damage Risk Study in children with Vesico Ureteral Reflux grade III to V Emilia Romagna Digestive, Kidney and Urological Systems 5,5 600.000 2310812 Effect of supervised exercise training on risk of fractures in subjects with type 2 diabetes Lazio Endocrinology, Metabolism, Nutrition and Reproductive Sciences 5,5 180.000 2320172 Assessment of short and long term risk benefit profile of biologics through healthcare database network in Italy Sicilia Population Sciences and Epidemiology 5,5 300.000 2318508 Modulation of metabolic mechanisms in muscle loss disorders: involvement of autophagy and apoptosis. SAN RAFFAELE PISANA Musculoskeletal, Oral and Skin Sciences 5,5 450.000 2310935 Oculo auriculo vertebral spectrum: use of an integrated high throughput platform to identify the disease causing genes and implications in clinical diagnostics CASA SOLLIEVO SOFFERENZA Genes, Genomes and Genetics 5,5 250.000 2308334 NEW THERAPEUTICS AND IMMUNOGENS GENERATED BY INCORPORATING SHORT RNAs AND PROTEIN ANTIGENS IN EXOSOMES Istituto Superiore di Sanita' Bioengineering Sciences and Technologies 5,5 588.000 2319394 A multidisciplinary study to investigate the molecular bases of hereditary tubulointerstitial nephritis Digestive, Kidney and Urological Systems 5,5 600.000 2313899 Biomolecular and functional analysis of pathogenetic mechanisms of neuropathic pain in genetic and acquired small fibre neuropathies. Istituto Scienze Neurologiche Molecular, Cellular, and Developmental 5,5 422.000 2314356 IDENTIFICATION OF GENES FOR RARE DEVELOPMENTAL DISORDERS BY NEXT GENERATION SEQUENCING GASLINI Genes, Genomes and Genetics 5,5 600.000 2315840 Alternative splicing as a tool to develop novel diagnostic and therapeutic approaches to control cancer growth. MAUGERI Oncology 1 Basic 5,75 600.000 (2) 2304056 Neuropsychological, neurofunctional and epigenetic effects of structured group patient education in type 2 diabetes. Piemonte Endocrinology, Metabolism, Nutrition and Reproductive Sciences 5,75 150.000 Pagina 3 di 142

2317761 TRANSLATING MELANOMA EPIGENETICS IN THE NICAL SETTING OF COMBINED CHEMO IMMUNOTHERAPIES Toscana Oncology 2 5,9 450.000 2321465 RH Project: Advanced Serological and Molecular Investigation for the RhD Variants Definition Lazio Cell Biology 6 300.000 2312620 IL 6 related inflammation signatures as a predictive marker of recurrence in liver cancer patients ISTITUTO TUMORI MILANO Oncology 2 6 568.800 2314711 THE ITALIAN REGISTRY FOR MYOTONIC DYSTROPHIES SAN DONATO Population Sciences and Epidemiology 6 450.000 2311484 Repetitive TMS modulation of the default mode network to clarify the pathophysiology of Alzheimer s disease and prompt a new therapeutic perspective SANTA LUCIA Brain Disorders and 6 599.500 2321151 PHASE I/II TRIAL OF NOGA GUIDED ENDOCAVITARY INJECTION OF BONE MARROW DERIVED CD133+ CELLS IN ISCHEMIC REFRACTORY CARDIOMYOPATHY (RECARDIO TRIAL) MONZINO Cardiovascular and 6 346.500 2318330 Epigenetic drugs for human diabetic foot ulcer treatment ISTITUTO DERMOPATICO DELL'IMMACOLATA Musculoskeletal, Oral and Skin Sciences 6 550.000 2312912 And yet they MOve: immobile patients re enter the physical world through embodiment in avatar or robot surrogates SANTA LUCIA Biobehavioral and Behavioral Processes 6 588.500 2309921 IS DES ACYL GHRELIN THE KEY MEDIATOR OF KETOGENIC DIET? Emilia Romagna Brain Disorders and 6 470.000 2303119 B7.1 on podocytes: a new therapeutic target for diabetic nephropathy Digestive, Kidney and Urological Systems 6 590.000 2306943 Development and preclinical validation of a nanotechnological platform that targets the minimal residual disease (MRD) in Cancer Calabria Oncology 2 6 600.000 Pagina 4 di 142

2305128 FSHD muscular dystrophy: molecular pathogenesis and prospects for therapy. Genes, Genomes and Genetics 6 600.000 2314610 Relevance of the CD4+ T lymphocytes and synoviocytes cross talk in the pathogenesis of human rheumatoid arthritis and juvenile idiopathic arthritis diseases. Toscana Immunology 6 480.000 2317808 Improving balance through gravity cues embedded in free falling target SANTA LUCIA Biobehavioral and Behavioral Processes 6 477.330 2316961 Molecular mechanisms underlying the skin inflammation triggered by Epidermal Growth Factor inhibitors and search for molecular targets for its correction ISTITUTO DERMOPATICO DELL'IMMACOLATA Musculoskeletal, Oral and Skin Sciences 6 350.000 2314035 Mechanisms of neurodegeneration and phenotypic heterogeneity in inherited prion diseases: physiopathological involvement of prion proteins in membrane trafficking and signaling Lombardia Brain Disorders and 6 450.000 2317822 "Epigenetic mechanisms in the control of viral transcription/replication in chronic HBV patients antiviral treatments: an integrated approach to the new biomarkers identification and rational clinical decisions. MAGGIORE Digestive, Kidney and Urological Systems 6 150.200 2316780 Humanized tumor mice: a new model that improves translational biomedical research to develop new personalized therapies in ovarian cancer. PASCALE Oncology 1 Basic 6 600.000 2321718 Cognitive efficiency and functional connectivity across the lifespan. Is there a signature of abnormal cognitive decline? S.CAMILLO Brain Disorders and 6 280.000 2312048 THE IRON INFLAMMATION LIPID CONNECTION REVEALED BY HEPCIDIN REGULATION STUDIES: RELEVANCE FOR THE CORRESPONDING NICAL DISORDERS Vascular and Hematology 6 600.000 2312059 Separation anxiety, CO2 Hypersensitivity and Panic: Epigenetic Mechanisms in Response to Adversities in Animal and Man Population Sciences and Epidemiology 6 597.000 Pagina 5 di 142

2313809 MECHANISMS OF VASCULAR DYSFUNCTION IN OBESITY RELATED METABOLIC SYNDROME. Lazio Vascular and Hematology 6,25 257.000 2321362 Phenotyping COPD patients and assessing disease severity by means of a standardized model Toscana Cardiovascular and 6,25 150.000 2311148 The use of OXT as adjunctive therapy for the treatment of schizophrenia: a randomized, double blind trial FATEBENEFRATELLI Biobehavioral and Behavioral Processes 6,25 500.000 2312341 Identification and validation of new therapeutic targets in Acute Myeloid Leukaemia I.E.O. Oncology 1 Basic 6,5 490.000 2314794 Pancreas transplantation in type 1 diabetic patients revealed a potential novel stem cell based mechanism that revert diabetic enteropathy Digestive, Kidney and Urological Systems 6,5 580.000 2306851 Genetics of Hearing loss: from basic research to clinical applications BURLO GAROFALO Genes, Genomes and Genetics 6,5 327.000 2313220 Mapping progressive neurodegeneration in amyotrophic lateral sclerosis (ALS): a multiparametric study combining clinical, cognitive, genetic, and neuroimaging assessment to identify predictors of ALS evolution Brain Disorders and 6,5 600.000 2310623 A PERSONALIZED MEDICAL APPROACH TO TREAT BACTERIAL INFECTIONS IN PATIENTS WITH LIVER CIRRHOSIS. Emilia Romagna Digestive, Kidney and Urological Systems 6,5 225.000 2319806 CAPNAF FD. A Computer Assisted Procedure for Nasal Air Flow assessment with modern Fluid Dynamics techniques. applications: individual surgical planning of nasal breathing difficulties treatment aimed at optimizing surgical procedures towards max Lombardia Surgical Sciences, Biomedical Imaging, and Bioengineering 6,5 220.000 2304833 Novel markers based on autophagy proteins in Parkinson's disease NEUROMED Brain Disorders and 6,5 300.000 2309849 Genotype phenotype characterization of the pathogenetic expansion of the C9ORF72 gene in a large series of Italian familial and sporadic ALS patients Piemonte Brain Disorders and 6,5 296.000 Pagina 6 di 142

2315477 Investigation on the sensitivity of dorsal raphe serotonergic neurons to hypercapnic stimuli in a transgenic mouse model of Sudden Infant Death Syndrome (SIDS) characterised by selective alteration of serotonergic neuron autoinhibition. Toscana Molecular, Cellular, and Developmental 6,5 235.000 2318728 Mechanisms of diabetes resolution after bariatric surgery: role of the gut Toscana Endocrinology, Metabolism, Nutrition and Reproductive Sciences 6,5 207.000 2315953 Regulation of mitotic transitions I.E.O. Cell Biology 6,5 518.000 2312954 Development of new experimental models for intellectual disabilities syndromes studying IL1RAPL1 function in synapse formation CARLO BESTA Molecular, Cellular, and Developmental 6,5 430.000 2305564 ALZHEIMER'S DISEASE LYSOSOMAL ENZYMES: NEW DIAGNOSTIC AND THERAPEUTIC TOOLS Umbria Brain Disorders and 6,5 600.000 2306317 Pathogenesis, diagnosis and course of familial and sporadic Alzheimer s disease and Frontotemporal Lobar Degeneration: epigenetics and proteomics as new tools for disease mechanisms and biomarker discovery MAGGIORE Brain Disorders and 6,5 599.886 2309299 Liver targeted cell therapy: applications to experimental Glycogen Storage Disease type 1a GASLINI Genes, Genomes and Genetics 6,5 385.000 2320871 Tipping the balance between adaptive/maladaptive endoplasmic reticulum stress responses to counter degenerative and storage diseases Cell Biology 6,5 600.000 2311782 Neural and behavioural recovery based on Rho GTPases modulation in a mouse model of Rett syndrome Istituto Superiore di Sanita' Brain Disorders and 6,5 407.000 2312197 DRUG TRANSPORTERS AND RESISTANCE TO TREATMENT OF OVARIAN CARCINOMA ISTITUTO TUMORI MILANO Oncology 2 6,5 463.100 Pagina 7 di 142

2309469 Structural genomics/proteomics and solution characterization of proteins of biomedical interest: development of a comprehensive facility, application to therapeutic monoclonal antibodies quality control, and to the fibrin(ogen) integrins cell matrix inter IRCCS AOU San Martino IST (Genova) Biological Chemistry and Macromolecular Biophysics 6,5 534.500 2319060 A phase I II clinical trial with central memory donor T cells expressing a suicide gene in the context of haploidentical hematopoietic stem cell transplantation for the treatment of chemoresistant acute leukemia. Oncology 2 6,5 550.000 2312272 The role of DNA repetitive elements mobilization in DMD pathogenesis, progression and treatment SANTA LUCIA Genes, Genomes and Genetics 6,5 585.200 2314699 Molecular regulation of the redox switch in inflamed skeletal muscle as a novel target to implement muscle regeneration and limit fibrosis in immune mediated myositis Musculoskeletal, Oral and Skin Sciences 6,5 524.000 2315681 Assessment of safety parameters in cultured mesenchymal stromal cells for use in regenerative medicine. Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia Veterinary 6,5 300.000 2310622 Search for genetic risk factors in sporadic Amyotrophic Lateral Sclerosis by exome sequencing in patients with a distinct phenotype. SAN RAFFAELE PISANA Brain Disorders and 6,5 240.000 2316644 Characterization of human amniotic mesenchymal stem cells (ha MSCs) isolated from obese women at delivery to identify gene or protein alterations predisposing the newborn to obesity. SDN Endocrinology, Metabolism, Nutrition and Reproductive Sciences 6,75 350.000 2317168 Prognostic value of a combined panel of soluble and genetic biomarkers in patients with early arthritis RIZZOLI Musculoskeletal, Oral and Skin Sciences 7 600.000 2309954 Reorganization of cortical function after surgery for lesional epilepsy in children Toscana Brain Disorders and 7 250.000 2319113 GRID based System for the Evaluation of the effects of Cognitive Rehabilitation in Patients with Alzheimer s Disease and Parkinson s Disease SAN RAFFAELE PISANA Brain Disorders and 7 540.000 Pagina 8 di 142

2317709 Improving strategies for preventing pertussis in infants OSPEDALE BAMBINO GESU' Infectious Diseases and Microbiology 7 480.000 2310098 Mutations in ANKRD26 cause a novel inherited thrombocytopenia at risk of developing acute leukemia: dissecting the clinical and molecular consequences of ANKRD26 mutations to better understand the mechanisms of both thrombocytopenia and leukemia SAN MATTEO Genes, Genomes and Genetics 7 350.000 2318689 Extracorporeal Life Support in Acute Respiratory Distress Syndrome (ELSA) Lombardia Cardiovascular and 7 300.000 2314890 SALUTE CKD (SALt lowering by Urine sodium selfmeasurement Trial in Chronic Kidney DiseasE) Calabria Risk, Prevention and Health Behavior 7 550.000 2312173 Anterior Cruciate Ligament Reconstruction: biomechanical modeling for treatment selection to prevent Osteoarthritis RIZZOLI Musculoskeletal, Oral and Skin Sciences 7 600.000 2313988 Peptides from lactoferrin as new therapeutic agents against Influenza virus infection Istituto Superiore di Sanita' Infectious Diseases and Microbiology 7 550.000 2317018 To unravel the molecular basis of neurodevelopmental disorders CASA SOLLIEVO SOFFERENZA Genes, Genomes and Genetics 7 500.000 2315788 Role of APOBEC1 in the initiation and progression of cancer Toscana Oncology 1 Basic 7 564.000 2320100 Angelman Syndrome: a clinical and functional imaging, molecular and biochemical investigation to uncover new therapeutic strategies MEDEA Brain Disorders and 7 598.500 2314540 Epidrugs and cardiac differentiation: relevance for the 22q11.2 deletion syndrome NEUROMED Cardiovascular and 7 307.200 2315413 Inflammation and oxidative stress in preeclampsia: role of the maternal endothelium and of the placenta potential role in early markers development Lombardia Biology of Development and Aging 7 322.000 2321065 Dissection of metabolic pathways involved in therapeutic plasticity of mesenchymal stem cells IRCCS AOU San Martino IST (Genova) Immunology 7 205.000 Pagina 9 di 142

2310803 Enhanced cell proliferation for muscle repair and regenerative medicine Istituto Superiore di Sanita' Musculoskeletal, Oral and Skin Sciences 7 507.778 2310860 Cytokines as biomarkers of disease and therapeutic targets in laminopathies RIZZOLI Biology of Development and Aging 7 400.000 2314855 Mitochondrial targeting in LRRK2 associated parkinsonism (PARK8) SANTA LUCIA Brain Disorders and 7 495.000 2310236 A novel anti CXCR4 drug RFF 1: a Phase I/II clinical trial. PASCALE Oncology 2 7 594.000 2312483 PRENICAL DEVELOPMENT OF THERAPEUTIC, ANTI BETA GLUCAN ANTIBODIES FOR UNIVERSAL PROTECTION AGAINST FUNGAL PATHOGENS Istituto Superiore di Sanita' Infectious Diseases and Microbiology 7 455.001 2310331 Towards a functional classification of human melanoma: dissecting the altered intracellular signaling profile by phosphoproteomics approaches. ISTITUTO TUMORI MILANO Oncology 1 Basic 7 234.300 2309607 Skeletal muscle in Spinal and Bulbar Muscular Atrophy (SBMA): therapeutic target and delivery route for potential treatments Veneto Brain Disorders and 7 350.000 2308303 A translational approach to restrain local recurrence in early breast cancer patients C.R.O. AVIANO Oncology 1 Basic 7 340.000 2314857 CCL2/CCR2 BLOCKING: MOLECULAR INSIGHTS INTO A POTENTIAL THERAPEUTIC STRATEGY AGAINST HIV REPLICATION Istituto Superiore di Sanita' AIDS and Related Research 7 390.000 2309290 Production of novel diagnostic and therapeutic antibodies directed against stem cells in colorectal and lung cancer REGINA ELENA Oncology 2 7 580.000 2318713 Investigating the molecular mechanisms leading to genome instability in tumours: analysis of role of the replication stress response and its potential for early diagnosis and target therapy of cancer Istituto Superiore di Sanita' Oncology 1 Basic 7 561.000 Pagina 10 di 142

2319439 Dysregulated RNA metabolism in multiple myeloma. Oncology 1 Basic 7 350.000 2315043 Adoptive immunotherapy for the prevention of Hepatitis C Virus (HCV) recurrence after liver transplantation Sicilia Infectious Diseases and Microbiology 7 270.000 2320721 Interaction between genetic and epigenetic variation of BDNF on cognition, brain activity and risk for schizophrenia CASA SOLLIEVO SOFFERENZA Brain Disorders and 7 450.000 2303934 Identification of new genes involved in the pathogenesis of rare congenital hemolytic anemias. MAGGIORE Genes, Genomes and Genetics 7,25 540.000 2314989 Innovative molecular platform for tick borne diseases: suspension array and pyrosequencing for the rapid, accurate and cost effective multi pathogen detection in ticks and biological samples Istituto Zooprofilattico Sperimentale delle Venezie Veterinary 7,25 420.000 2318074 IDENTIFICATION OF INNOVATIVE MARKERS AND TECHNOLOGIES FOR SCREENING, DIAGNOSIS AND PROGNOSTIC EVALUATION OF PROSTATE CANCER: CORRELATION WITH ESTABLISHED NICAL PARAMETERS MULTIMEDICA Oncology 2 7,5 449.700 (2) 2321592 From carcinogenesis to tumor progenitor cells: mirnaome/methylome reprogramming impact on diagnostic and therapeutic innovative options in colorectal cancer CASA SOLLIEVO SOFFERENZA Oncology 1 Basic 7,5 600.000 2313550 Immunological monitoring of advanced cancer patients undergone active specific immunotherapy with a new anti cancer poly peptide vaccine directed against the thymidylate synthase enzyme. Toscana Oncology 2 7,5 154.000 2321713 Integrated program of clinical research to reduce the mortality rate of patients on the waiting list for lung transplantation Piemonte Cardiovascular and 7,5 250.000 2313650 White Blood Cells expression profiles as a tool for predicting Metformin Efficacy in Patients with Type 2 Diabetes CASA SOLLIEVO SOFFERENZA Genes, Genomes and Genetics 7,5 410.000 Pagina 11 di 142

2316319 Evaluation of interaction between NK cells and colorectal carcinoma cells for development of NK cellbased immunotherapy in patients with refractory disease SAN MATTEO Oncology 2 7,5 500.000 2304750 Role of estrogen receptors in the pathogenesis and response to treatment of chronic lymphocytic leukemia Istituto Superiore di Sanita' Oncology 1 Basic 7,5 590.000 2316548 Innovative approaches for the treatment of Pompe disease: characterization and identification of potential therapeutic targets in patients with the splicing c. 32 13T>G common mutation and pharmacological chaperoning of alpha glucosidase Friuli Venezia Giulia Genes, Genomes and Genetics 7,5 474.100 2318965 Aedes albopictus in northern Italy: molecular markers and mathematical models to predict its potential future spread and the impact of control strategies Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia Veterinary 7,5 299.000 2312006 Role of the RNA binding protein Sam68 in the regulation of SMN2 splicing: implications for novel therapeutic approaches to Spinal Muscular Atrophy SANTA LUCIA Genes, Genomes and Genetics 7,5 543.000 2312510 IMPACT OF CDKL5 ON NEURONAL FUNCTIONS: GENETIC AND PROTEIN TARGETS, MOLECULAR PATHWAYS AND NEURONAL CIRCUITS Molecular, Cellular, and Developmental 7,5 338.000 2319302 Structural and functional imaging markers of motor control dysfunction in Tourette syndrome. GALEAZZI Brain Disorders and 7,5 320.000 2316099 CROHN'S DISEASE: MECHANISMS OF INTESTINAL FIBROSIS, GENETIC PREDISPOSITION, AND POSSIBLE IMPLICATIONS FOR THERAPEUTIC AND DIAGNOSTIC INTERVENTION CASA SOLLIEVO SOFFERENZA Genes, Genomes and Genetics 7,5 475.000 2302021 AUTOPHAGY AS A NOVEL POTENTIAL DRUG TARGET IN DUCHENNE MUSCULAR DYSTROPHY:IDENTIFICATION OF THE PATHWAYS AND NEW PHARMACOLOGICAL STRATEGIES MEDEA Musculoskeletal, Oral and Skin Sciences 7,5 600.000 2315312 Role of novel modulators of ectopic mineralization during aortic valve disease progression Veneto Vascular and Hematology 7,5 375.000 Pagina 12 di 142

2314131 Circulating nucleic acids in colorectal cancer patients as markers of tumor stroma interactions: new tools for early diagnosis and risk assessment ISTITUTO TUMORI MILANO Oncology 2 7,5 599.500 2308418 GENETIC AND MOLECULAR STUDIES OF TWO AUTISM GENES WITH DIRECT NICAL IMPLICATIONS SANTA LUCIA Brain Disorders and 7,5 450.000 2309562 INHIBITION OF BACTERIAL FILMS: NEW MOLECULAR STRATEGIES TARGETING CYC DI GMP METABOLISM Lazio Infectious Diseases and Microbiology 7,5 210.000 2311417 MicroRNAs regulated by mutated p53 oncoproteins in colon cancer REGINA ELENA Oncology 1 Basic 7,5 230.000 2310804 The role of the EGFR in the interaction between mesenchymal stem cells and breast cancer cells: implications for novel therapeutic approaches PASCALE Oncology 1 Basic 7,5 285.000 2315284 Modulation by IL 1beta of GABAA Receptors function in human and experimental epilepsy: a novel therapeutic approach against adult and childhood intractable epilepsies. SAN RAFFAELE PISANA Brain Disorders and 7,5 450.000 2317173 Role of MSY3 in skeletal muscle maturation and degeneration: a new potential target for therapies against muscle wasting disorders. SAN RAFFAELE PISANA Musculoskeletal, Oral and Skin Sciences 7,5 500.000 2321799 Parenteral Iron Supplementation, Chemoreflex Response, Quality of Life And Exercise Capacity In Patients With Chronic Heart Failure AUXOLOGICO Cardiovascular and 7,8 313.000 2315604 Electronic health databases as a source of reliable information for effective health policy Puglia Healthcare Delivery and 8 150.000 2316063 EFFICACY OF TELEMEDICINE FOR IMPROVING DEPRESSION OUTCOMES IN PRIMARY CARE FATEBENEFRATELLI Healthcare Delivery and 8 500.000 2321788 Hyperpolarized 13C Magnetic Resonance Metabolic Imaging as Sensitive Biomarker in a cardiac translational study of Heart Failure Toscana Cardiovascular and 8 550.000 Pagina 13 di 142

2308551 Role of antiviral treatment on the course of severe liver disease due to chronic HCV infection Sicilia Digestive, Kidney and Urological Systems 8 165.000 2313991 Toward the development of an in vitro test for ALS: largescale validation of PBMC protein biomarkers Lombardia Brain Disorders and 8 375.000 2309734 Does calorie restriction ameliorate renal function and cardiometabolic health in obese type 2 diabetic patients? Istituto Superiore di Sanita' Endocrinology, Metabolism, Nutrition and Reproductive Sciences 8 583.500 2309222 Towards development of a next generation sequencing strategy for molecular genetic testing of inherited diseases with blood cell reduction BURLO GAROFALO Vascular and Hematology 8 225.000 2312766 A multicenter collaborative research network for the identification and study of rare undiagnosed patients: the impact on the rare disease National Health Service network (UnRareNet) OSPEDALE BAMBINO GESU' Healthcare Delivery and 8 600.000 2302814 MiRNAs in Forebrain Neurogenesis Biology of Development and Aging 8 220.000 2307568 Role of autophagy in growth, progression and vascular mimicry of neuroblastoma GASLINI Oncology 1 Basic 8 425.000 2310231 MOLECULAR EVENTS RESPONSIBLE FOR MIGRATORY PLASTICITY AND INVADOPODIA FORMATION IN BONE METASTASIS FROM BREAST CARCINOMA GALEAZZI Oncology 1 Basic 8 500.000 2317994 Role of microrna regulation by estrogen receptor beta in hormone responsive breast cancer CROB Oncology 1 Basic 8 360.000 2311626 Germline predictors of survival and response to therapy in malignant melanoma: from GWAS to high resolution mapping and functional analysis IRCCS AOU San Martino IST (Genova) Oncology 1 Basic 8 572.000 2311575 Development of novel cell products for their clinical use in cancer immunotherapy Istituto Superiore di Sanita' Oncology 2 8 600.000 Pagina 14 di 142

2308936 MALIGNANT MESOTHELIOMA. ROLE OF INFLAMMATION IN TUMOUR PROGRESSION UNDER HYPOXIC CONDITIONS: IDENTIFICATION OF NEW MARKERS AND THERAPEUTIC TARGETS. REGINA ELENA Oncology 1 Basic 8 300.000 2314623 Immunomodulation by mesenchymal stem cells as a potential therapeutic strategy for endometriosis Endocrinology, Metabolism, Nutrition and Reproductive Sciences 8 450.000 2308613 Monitoring and development of innovative therapies through microvesicle analysis in kidney and in liver transplantation Piemonte Digestive, Kidney and Urological Systems 8 300.000 2317169 NACHNOLOGY FOR THE DELIVERY OF ZOLEDRONIC ACID: A NEW OPPORTUNITY AGAINST CANCER REGINA ELENA Oncology 2 8 467.500 2318396 Identification of novel disease genes for Noonan syndrome and related RASopathies and insights into pathogenetic mechanisms for supporting diagnosis, management and treatment Istituto Superiore di Sanita' Genes, Genomes and Genetics 8 600.000 2316177 Evaluation of the potential neuroprotective, antiepileptogenic and anticonvulsive properties of Palmitoylethanolamide (PEA) Calabria Brain Disorders and 8 200.000 2311388 Histaminergic H4 receptor may have a role in autoimmune and inflammatory neuropathologies: studies on the selective H4R agonists and antagonists in animal models in vivo. Toscana Brain Disorders and 8 320.000 2321817 Functional and gene expression profile of VH1 69+ primary cutaneous B cell lymphomas and HCV associated lymphomas ISTITUTO DERMOPATICO DELL'IMMACOLATA Oncology 1 Basic 8 330.000 2309698 Functional characterization and identification of corrective strategies for SCN5A mutations causing Long QT Syndrome 3 and brugada Syndrome. MAUGERI Cardiovascular and 8 590.000 2302816 NOVEL THERAPIES FOR TUBERCULOSIS Istituto Superiore di Sanita' Infectious Diseases and Microbiology 8 550.000 Pagina 15 di 142

2313919 Identification of therapeutic targets for neurological disorders: analysis of the mechanisms regulating cortical interneurons development. Molecular, Cellular, and Developmental 8 420.000 2311298 Targeting CD99 to treat sarcomas RIZZOLI Oncology 2 8 497.200 2314146 Modeling the neurological features of Tuberous Sclerosis Complex by exploiting neural stem cells: translating the results of basic research into predictive preclinical tools. Brain Disorders and 8 360.000 2299726 Characterization of micro vesicles in plasma and urine of Alzheimer s disease patients: possible new biomarkers of neurodegeneration S.CAMILLO Brain Disorders and 8 260.000 2305089 Novel therapeutic strategies for Amyotrophic Lateral Sclerosis: testing the efficacy of cell permeable peptides in preclinical models MAUGERI Brain Disorders and 8 200.000 2298318 Kinetochore spindle binding as a new anticancer drug target. I.E.O. Oncology 2 8 521.300 2321111 IMPROVING SAFETY OF GENE TRANSFER FOR GENE THERAPY APPLICATIONS Genes, Genomes and Genetics 8 600.000 2320121 Preclinical evaluation of isoform specific PI3K inhibitors' effects in pulmonary fibrosis models for novel potential therapies of Idiopathic pulmonary fibrosis (IPF) Sicilia Cardiovascular and 8 540.000 2321706 The rehabilitation of attention in patients with mild cognitive impairment and brain subcortical vascular changes using the Attention Process Training II Toscana Brain Disorders and 8 160.000 2314704 Evaluation of the activity of HIV protease or reverse transcriptase inhibitors against experimental models of uterine cervical tumours Istituto Superiore di Sanita' Oncology 2 8 600.000 Pagina 16 di 142

2316606 Optimization of alloreactive natural killer (NK) cell and invariant NKT (inkt) cell mediated anti leukemia effect in children with hematological malignancies given a T cell depleted hematopoietic stem cell transplantation (HSCT) from an HLA disparate rel OSPEDALE BAMBINO GESU' Oncology 2 8 600.000 2315136 MSC based therapy for the bone marrow and solid organs transplantations Lombardia Oncology 2 8 200.500 2313155 Effects of resveratrol on inflammation in type 2 diabetic patients. A double blind randomised controlled trial Piemonte Endocrinology, Metabolism, Nutrition and Reproductive Sciences 8 160.000 2315304 Advanced MRS, ASL perfusion and structural MRI in pediatric migraine: a longitudinal study and correlations with clinical and neurophysiological findings. OSPEDALE BAMBINO GESU' Brain Disorders and 8 455.000 2312559 A pathology for the MET oncogene: "cancers of unknown primary origin" (CUPs) Piemonte Oncology 1 Basic 8 300.000 2311360 EPIDEMIOLOGICAL SURVEY ON FRESHWATER FISH BORNE PARASITIC ZOONOSES: STUDY OF TIC AND ATIC FACTORS INFLUENCING THE OCCURRENCE OF ZOONOTIC HELMINTHS IN FRESHWATER FISH POPULATIONS FROM NORTHERN ITALY AND IDENTIFICATION OF MAIN RISK FACTORS CONTRIBUTIN Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta Veterinary 8 576.125 2313291 2321704 The novel low density lipoprotein associated protein prenylcysteine lyase: understanding its functional role Evaluation of anti NA antibodies as possible correlates of protection from influenza disease: development of serological assays designed to detect a truly functional antibody response to influenza vaccination, with specific regard to the anti NA antibody MONZINO Vascular and Hematology 8 577.778 Istituto Superiore di Sanita' Immunology 8 523.600 2316374 Familial breast cancer cases from an isolated population: detection of new risk alleles by exome sequencing and depiction of mutation spectrum in known susceptibility genes. Lombardia Oncology 1 Basic 8,25 302.600 Pagina 17 di 142

2320644 THE RESPONSIVENESS TO CLOPIDOGREL AND STENT THROMBOSIS 3 (RECLOSE 3) TAILORED THERAPY Toscana Cardiovascular and 8,5 600.000 2314047 LKB1/AMPK status and glycolytic phenotype as biomarkers of response of lung cancer to bevacizumab I. O. V. Oncology 2 8,5 180.000 2309914 The tumorigenic action of eif6 translational network: 1. evaluation of eif6 inhibition in anticancer therapy and isolation of downstream eif6 targets; 2. generation of SBDS mutated cancer cells and evaluation of their drug sensitivity. Oncology 1 Basic 8,5 290.000 2315839 Direct Acting Antivirals (DAAs) for HCV infection: a nationwide research project to evaluate virological and clinical outcomes, to design appropriate treatment algorithms, and to assess cost effectiveness of the new combination therapies Istituto Superiore di Sanita' Infectious Diseases and Microbiology 8,5 600.000 2307262 Identification of treatment dependent and treatment independent biological predictors of chemorefractoriness and outcome in a phase III trial of high risk diffuse large B cell lymphoma (DLCL04) Provincia autonoma Bolzano Oncology 2 8,5 550.000 2318081 Anti idiotypic Network to Anti transglutaminase Antibodies in the Prevention of Celiac Disease Enteropathy. BURLO GAROFALO Digestive, Kidney and Urological Systems 8,5 200.000 2316524 An opportunistic screening strategy to improve the triage of skin cancer by primary care physicians A randomized study ARCISPEDALE Healthcare Delivery and 8,5 150.000 2317105 The contribution of ICT to patient safety in surgical process Emilia Romagna Healthcare Delivery and 8,5 200.000 2321254 Non inferiority trials for cutting drug expenses in neurology: comparing 2 interferon beta 1b regimes in Multiple Sclerosis Lazio Brain Disorders and 8,5 150.000 Pagina 18 di 142

2312316 Perioperative Optimization of Care in Obesity: Acronym: POCO Toscana Surgical Sciences, Biomedical Imaging, and Bioengineering 8,5 525.000 2315118 Investigation on the prognostic value of biochemical markers in the cerebrospinal fluid for the functional outcome of spinal cord injured patients Emilia Romagna Brain Disorders and 8,5 400.000 2316179 MOLECULAR EPIDEMIOLOGY OF METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS IN A THIRD LEVEL PAEDIATRIC UNIVERSITY HOSPITAL Toscana Infectious Diseases and Microbiology 8,5 345.000 2318922 Care pathway for dementia: effects on professional practice, patient outcomes, and costs for the NHS. CARLO BESTA Brain Disorders and 8,5 550.000 2321801 Development and testing of an entirely automated system, based on administrative data, to stratify prognosis of older patients accessing an Emergency Department Toscana Healthcare Delivery and 8,5 200.000 2308322 Development of new antiinflammatory/immunosuppressive therapy to improve the outcome of brain injury. NEUROLESI Brain Disorders and 8,5 600.000 2317319 Ceruloplasmin oxidation in Parkinson s disease cerebrospinal fluid: role in pathological mechanisms Brain Disorders and 8,5 330.000 2317235 Targeting Toll like receptors (TLRs) and their endogenous ligand high mobility group box 1 (HMGB1) as novel therapeutic strategy for Amyotrophic Lateral Sclerosis. Lombardia Brain Disorders and 8,5 250.000 2312443 ISCHEMIC REMOTE POST CONDITIONING AS A NEW THERAPEUTIC STRATEGY TO TREAT CEREBRAL ISCHEMIA SDN Molecular, Cellular, and Developmental 8,5 419.600 2320979 Genomics, epigenomics and transcriptomic investigation of defective peripheral tolerance in IPEX like patients Genes, Genomes and Genetics 8,5 600.000 2321552 The use of an innovative microarray platform into the clinical setting Sicilia Genes, Genomes and Genetics 8,5 597.300 Pagina 19 di 142

2309591 Impact of asbestos mediated inflammation in mesothelioma genesis and progression. Implication for early diagnosis, prognosis and therapy HUMANITAS Oncology 1 Basic 8,5 600.000 2318847 THE ROLE OF CELL FUSION INDUCED BY TETRASPANIN CD81/CD9 MULTIPROTEIN COMPLEX AS MECHANISM OF CHEMORESISTANCE IN COLON CARCINOMA Toscana Oncology 2 8,5 223.000 2313645 Paracrine role of Mesenchymal Stem Cells (MSCs) for cell therapy in ALS Piemonte Molecular, Cellular, and Developmental 8,5 480.000 2309329 Searching for a common pathogenetic pathway causing muscle misfunctioning in different laminopathies RIZZOLI Cell Biology 8,5 300.000 2319289 DNA damage response and metabolic alterations of obesity Istituto Superiore di Sanita' Endocrinology, Metabolism, Nutrition and Reproductive Sciences 8,5 600.000 2309553 Recovery to heart donation of donor hearts with neurogenic stunning identified as eligible by stress echo viability assessment. Emilia Romagna Surgical Sciences, Biomedical Imaging, and Bioengineering 8,5 600.000 2317812 MOLECULAR AND FUNCTIONAL CHARACTERIZATION OF MECHANISMS INVOLVED IN IRON HOMESTASIS AND HEME SYNTHESIS IN BETA THALASSEMIC ERYTHROPOIESIS MAGGIORE Genes, Genomes and Genetics 8,5 500.000 2320908 Radiation biodosimetry in emergency: validation of automated scoring and accuracy of dose prediction. IRCCS AOU San Martino IST (Genova) Oncology 1 Basic 8,5 470.000 2306857 Investigation of the role of extracellular ATP and the P2X7 receptor in the modulation of imunosuppression within tumour microenvironment. Emilia Romagna Immunology 8,5 600.000 2312853 Search for disease associated genes and their functional mutations in high risk neuroblastoma by parallel massive coding sequences analysis and identification of druggable targets. IRCCS AOU San Martino IST (Genova) Oncology 1 Basic 8,5 531.500 Pagina 20 di 142

2308779 Molecular imaging and genome wide analysis: an integrated approach to identify early diagnostic biomarkers. REGINA ELENA Oncology 1 Basic 8,5 350.000 2306173 NUTRIGENOMICS IN PEDIATRIC INFLAMMATORY BOWEL DISEASES: A NEW BASIS FOR SERUM MARKERS DISCOVERY Veneto Digestive, Kidney and Urological Systems 8,5 252.785 2319311 NICAL RELEVANCE OF IMMUNE RESPONSES TO PROPHYLACTIC HPV VACCINE IN ITALY:A NATIONAL IMMUNOMONITORING NETWORK Istituto Superiore di Sanita' Immunology 8,5 600.000 2314538 Development of beta cell specific aptamers as novel diagnostic and therapeutic tools for diabetes mellitus. Surgical Sciences, Biomedical Imaging, and Bioengineering 8,5 566.000 2303697 Redox dysfunctions in autoinflammatory syndromes. Role in disease course, novel therapeutic approaches IRCCS AOU San Martino IST (Genova) Immunology 8,5 600.000 2298689 Functional relevance of Natural Killer cells in the pathogenesis of primary sclerosing cholangitis HUMANITAS Immunology 8,5 444.000 2308855 Paraganglioma syndrome associated with succinate dehydrogenase defects: toward the discovery of biomarkers and novel pharmacological therapies I. O. V. Oncology 1 Basic 8,5 343.200 2311253 Structural imaging in systemic amyloidosis: an inescapable step toward the optimization and validation of more effective therapeutic approaches SAN MATTEO Biological Chemistry and Macromolecular Biophysics 8,5 500.000 2321220 Generation of artificial lymphoid organs with mutipotent stromal progenitors derived from induced pluripotent stem cells. Biology of Development and Aging 8,5 500.000 2317811 Isolated Hemihyperplasia (IH), a pediatric cancer risk disease: search for novel genes and mechanisms AUXOLOGICO Genes, Genomes and Genetics 8,75 462.000 2312035 Purinergic modulation of SDF 1/CXCR4 directed endothelial and cardiac progenitors cell functions: theraupetic potential in cardiovascular regeneration. SAN RAFFAELE PISANA Cardiovascular and 8,75 450.000 Pagina 21 di 142

2312549 Heterotypic interactions in thrombo inflammatory processes associated with the thrombotic vascular occlusion in sepsis: the role of vitamin K dependent protein C Vascular and Hematology 8,75 600.000 2319551 A multicenter epidemiological and clinical study on Deep Brain Stimulation (DBS) for Parkinson s disease: adherence to current recommendations, safety and outcome. MAGGIORE Brain Disorders and 8,75 257.100 2319571 Noise and air pollution from road traffic and incidence of coronary and cerebrovascular events in three Italian cohort studies Lazio Population Sciences and Epidemiology 9 380.000 2312085 MODULATING NEUREGULIN 1 SIGNALS TO TREAT HEREDITARY DEMYELINATING NEUROPATHIES Molecular, Cellular, and Developmental 9 600.000 2313775 Molecular mechanisms of neutrophil recruitment as novel targets to curb lung damage in cystic fibrosis. Abruzzo Cardiovascular and 9 480.000 2318137 Targeting altered proton dynamics of sarcomas as an effective therapeutic tool RIZZOLI Oncology 2 9 600.000 2317828 NEURONAL POTASSIUM CHANNEL KV3.4 AS A NON TRADITIONAL MOLECULAR TARGET FOR THE DEVELOPMENT OF DRUGS PREVENTING NEURONAL CELL DEATH IN ALZHEIMER DISEASE SAN RAFFAELE PISANA Molecular, Cellular, and Developmental 9 360.000 2308980 Dissecting the CLL lipidome in search for novel prognostic markers and targets for tailored therapy Oncology 2 9 580.000 2309748 MAPPING THE CORTICOSPINAL TRACT: INVESTIGATION OF FUNCTIONAL PROPERTIES OF THE DIFFERENT CORTICAL AREAS ORIGINATING CST AND THEIR NICAL IMPACT ON TUMOR RESECTION AND PATIENT FUNCTIONAL OUTCOME HUMANITAS Integrative, Functional, and Cognitive 9 272.800 2319745 Presbyphagia: analysis of diagnostic criteria and identification of potential innovative treatments MONDINO Healthcare Delivery and 9 563.000 Pagina 22 di 142

2310570 DECISION SUPPORT SYSTEM TO IMPROVE APPROPRIATENESS OF REPEATED EXECUTION OF LABORATORY EXAMINATIONS Emilia Romagna Healthcare Delivery and 9 500.000 2320098 IMPACT OF VITAMIN D SUPPLEMENTATION ON SKELETAL AND NON SKELETAL MANIFESTATIONS IN PATIENTS WITH PRIMARY HYPERPARATHYROIDISM SUBMITTED TO PARATHYROIDECTOMY OR FOLLOWED WITHOUT SURGERY CASA SOLLIEVO SOFFERENZA Healthcare Delivery and 9 290.000 2314264 METHODS FOR NON INVASIVE QUANTITATIVE ASSESSMENT OF FATTY LIVER SDN Digestive, Kidney and Urological Systems 9 450.000 2317972 DNA vaccines coding for chimeric human/rat HER 2 as innovative immunotherapeutic tools for the treatment of HER2+ cancer patients Piemonte Oncology 2 9 270.000 2315893 Antiepileptic Drugs and pregnancy. Population based pharmaco epidemiological study on prescription patterns, pregnancy outcome and foetal health Istituto Scienze Neurologiche Population Sciences and Epidemiology 9 300.000 2318552 PREDICTION AND PREVENTION OF FALLS IN SUBJECTS SUFFERING FROM NEUROLOGICAL DISEASES Lombardia Risk, Prevention and Health Behavior 9 255.300 2319611 Brain Computer Interface driven rehabilitation after stroke: an add on intervention for hand motor recovery SANTA LUCIA Brain Disorders and 9 290.000 2319605 Polypharmacy Reduction of Inappropriate Medication and Adverse Drug Events in Older Patients: a Randomized Controlled Trial PRIMA Provincia autonoma Bolzano Healthcare Delivery and 9 205.000 2322017 The implementation of an enhanced recovery program ( fast track) after colorectal resection for colonic cancer Emilia Romagna Surgical Sciences, Biomedical Imaging, and Bioengineering 9 150.000 2321501 Biological bone reconstruction in children skeleton after sarcoma resection. Validation of the technique through CT scan analysis and histological evaluation of the retrieved cases RIZZOLI Surgical Sciences, Biomedical Imaging, and Bioengineering 9 350.000 Pagina 23 di 142

2318554 Assessment of Stable and Unstable atherosclerotic plaque in coronary disease using Positron Emission Tomography Computed Tomography (PET TC) and Optical Coherence Tomography (OCT).[SUSPECT trial] Lazio Cardiovascular and 9 150.000 2312561 IMMUNOSUPPRESSIVE AND REGENERATIVE CAPACITY OF AUTOLOGOUS ADIPOSE DERIVED MESENCHIMAL STEM CELLS FOR THE TREATMENT OF PATIENTS WITH CROHN DISEASE Emilia Romagna Digestive, Kidney and Urological Systems 9 450.000 2319386 Exercise and inflammation in obesity. Evaluation of relationships and possible interventions. (ObInEx Project) DON GNOCCHI Endocrinology, Metabolism, Nutrition and Reproductive Sciences 9 162.000 2313100 Deep molecular mechanisms of amyloid beta peptide aggregation promoting Alzheimer s Disease: characterization with Nuclear Magnetic Resonance (NMR) techniques using an in vitro model of anesthetic inducing oligomerization NEUROLESI Brain Disorders and 9 480.000 2314764 CHANGES IN STRUTTURE AND RECRUITMENT OF MUSCLE SYNERGIES AFTER CORTICAL AND CEREBELLAR LESIONS SANTA LUCIA Integrative, Functional, and Cognitive 9 354.889 2307228 Assessing the effect of an intensive rehabilitation treatment(irt) on neurotrophic factors production in patients with Parkinson s disease MAUGERI Brain Disorders and 9 200.000 2321796 Acute coronary syndrome and long term outcome: the role of nitric oxide synthesis in red blood cells MONZINO Cardiovascular and 9 389.500 2321812 Polymeric films and magnetic forces for gallbladder retraction during a fully translumenal cholecystectomy Piemonte Surgical Sciences, Biomedical Imaging, and Bioengineering 9 400.000 2318732 HIGH THROUGHPUT TECHNOLOGIES FOR UNCOVERING NEW DIAGNOSTIC MARKERS FOR EARLY DIAGNOSIS OF CHRONIC ALLOGRAFT INJURY IN RENAL TRANSPLANTATION (CAI) Puglia Digestive, Kidney and Urological Systems 9 550.000 Pagina 24 di 142

2318002 Novel multiplexing and signal amplification strategies for the development of advanced diagnostic platforms for animal health and food safety control Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia Veterinary 9 420.000 2317549 Aberrant choline metabolism in ovarian cancer as a source of multilevel data in prognosis and/or therapeutic guidance. ISTITUTO TUMORI MILANO Oncology 2 9 505.000 2311487 Muscle fibrosis in DMD: Molecular characterization with a new human in vitro model and therapeutic approach CARLO BESTA Musculoskeletal, Oral and Skin Sciences 9 376.100 2315686 Characterizations of the anti Tat adaptative immune responses in individuals naturally controlling HIV 1 replication AIDS and Related Research 9 580.000 2320691 MICRORNA IN THYROID CARCINOMA: PATHWAYS INVOLVED AND POSSIBLE PROGNOSTIC AND THERAPEUTIC IMPACT ISTITUTO TUMORI MILANO Oncology 1 Basic 9 300.000 2320339 Genetic characterization of supraventricular arrhythmias by whole exome sequencing Cardiovascular and 9 590.000 2321747 Early diagnosis, tumor response to neoadjuvant treatments and diagnosis of tumor recurrence using new and non invasive biomarkers in colon and rectal cancer I. O. V. Oncology 2 9 584.100 2320653 Role of trace element in the pathogenesis of Multiple sclerosis Istituto Superiore di Sanita' Population Sciences and Epidemiology 9 388.223 2318192 Oral steroids for reducing renal scarring in infants with febrile urinary tract infections at high risk for renal scar development: a randomized controlled trial Veneto Infectious Diseases and Microbiology 9 200.000 2313561 Defining non invasive outcome measures and elucidating the molecular mechanisms underlying muscle degeneration in Facioscapulohumeral muscular dystrophy DON GNOCCHI Musculoskeletal, Oral and Skin Sciences 9 493.000 2305963 Role of IBtk, a B cell signalling regulator, in cancer development. Calabria Cell Biology 9 460.000 Pagina 25 di 142

2317531 Recurrent herpes virus infections as risk factor for Alzheimer`s disease SAN RAFFAELE PISANA Infectious Diseases and Microbiology 9 600.000 2314491 Cortico cortical functional connectivity and recovery of post stroke spatial attention and awareness disorders SANTA LUCIA Integrative, Functional, and Cognitive 9 600.000 2316707 Revealing brain mechanisms of Chronic Subjective Dizziness SANTA LUCIA Integrative, Functional, and Cognitive 9 440.000 2317430 Advanced diagnosis and therapies for migraine caused by K+ channel dysfunction MONDINO Molecular, Cellular, and Developmental 9 562.000 2312253 Characterization of the genomic architecture of myelodysplastic syndromes and definition of a molecular basis for their classification and prognostication SAN MATTEO Oncology 1 Basic 9 486.000 2319429 MicroRNAs as molecular biomarkers for early detection of sporadic Fronto temporal Dementias Umbria Brain Disorders and 9 460.000 2316352 Identification of new biomarkers for metabolic syndrome associated with antipsychotic treatment FATEBENEFRATELLI Biobehavioral and Behavioral Processes 9 600.000 2299942 Epigenetic signatures in human glioblastoma cells: implications for tumor biology and treatment IRCCS AOU San Martino IST (Genova) Oncology 1 Basic 9 478.500 2302218 ADVANCED NICAL AND MOLECULAR EFFORTS IN HEREDITARY SPASTIC PARAPLEGIA STELLA MARIS Brain Disorders and 9 518.000 2298782 Role of Chromatin Remodeling in Epigenetic Cell Memory SANTA LUCIA Genes, Genomes and Genetics 9 500.000 2303797 Effect of proteasome and VEGF receptor inhibitors on NKG2D ligand expression on hepatocellular carcinoma cells: implications for immunotherapy of liver cancer. SAN MATTEO Oncology 2 9 350.000 2307872 THE ROLE OF CALCIUM HOMEOSTASIS IN DEVELOPMENTAL ATAXIAS: genetic dissection and functional characterization of a neuronal specific plasma membrane Ca2+ ATPase. OSPEDALE BAMBINO GESU' Molecular, Cellular, and Developmental 9 597.000 Pagina 26 di 142

2313251 An in vitro ad in vivo imaging approach to myelin dysfunction and reconstruction after stroke: role of GPR17, a new player in oligodendrocyte specification MONZINO Brain Disorders and 9 527.500 2308659 Pathogenesis of congenital human cytomegalovirus infection SAN MATTEO Infectious Diseases and Microbiology 9 590.000 2313671 A combination of surveys, spatial analyses and molecular epidemiology to get an insight of pre harvest risks from Shiga toxin producing Escherichia coli. Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta Veterinary 9 600.000 2305958 Optimization of plasma progranulin dosage for predicting null progranulin mutations in neurodegenerative diseases: A pilot Multicentre Italian Study for harmonization of procedures to be translated into clinical practice FATEBENEFRATELLI Brain Disorders and 9 580.000 2311550 Predictive factors of response to therapies in colorectal and breast cancers. MAUGERI Oncology 1 Basic 9,17 390.000 2312497 Adaptation to predictable postural perturbations: physiological basis for an innovative approach to dynamic balance training in Parkinson s disease MAUGERI Brain Disorders and 9,25 240.000 2308510 Prognostic utility of biological indicators in human colorectal cancer: the chemokine axis CX3CL1/CX3CR1 HUMANITAS Oncology 1 Basic 9,5 549.000 2308203 Sirt1 and Sirt2 as targets for the manipulation of the proliferative processes associated to physiopathologic conditions of the skin ISTITUTO DERMOPATICO DELL'IMMACOLATA Musculoskeletal, Oral and Skin Sciences 9,5 490.000 2313520 A CORRELATIVE, NEUROIMMUNOVIROLOGICAL AND MRI ANALYSIS OF PROGNOSTIC MARKERS IN ALZHEIMER'S DISEASE DON GNOCCHI Brain Disorders and 9,5 410.000 2315853 Understanding and enhancing the therapeutic effect of FTY720 (Fingolimod) in multiple sclerosis: a structural biology approach Biological Chemistry and Macromolecular Biophysics 9,5 550.000 Pagina 27 di 142

2314680 Circulating tumor cells, with stem like and/or epithelialmesenchymal transition features, detectable in peripheral blood of breast cancer patients: biological and clinical significance ISTITUTO TUMORI MILANO Oncology 2 9,5 444.756 2312842 Dominant optic atrophy (DOA) and OPA opathies in Italy: prevalence, phenotypes, genes and functional studies towards a therapy Istituto Scienze Neurologiche Brain Disorders and 9,5 425.000 2310624 An integrated genomic and immunologic approach to novel strategies of monitoring and therapy for HBV and HCV infections Emilia Romagna Infectious Diseases and Microbiology 9,5 600.000 2315446 Ageing at work: promoting health and safety of ageing workers according to changes of demography, labour market and social policies. MAGGIORE Risk, Prevention and Health Behavior 9,5 555.000 2316458 Transcriptomic profiling in circulating mesenchymal stem cells of patients with degenerative diseases. Veneto Genes, Genomes and Genetics 9,5 437.000 2313113 Whole genome scanning in AML to develop a better prognostic stratification and personalized risk based therapies SAN MATTEO Oncology 2 9,5 300.000 2314784 Food irradiation: quality and detection of plant origin food with health benefits Istituto Zooprofilattico Sperimentale della Puglia e della Basilicata Veterinary 9,5 550.000 2319226 In vivo toxi omic signatures for brain and thyroid function: combined exposure to mixtures of endocrine disrupting chemicals and iodine deficiency in animal models and translation to epidemiological/clinical studies Istituto Superiore di Sanita' Endocrinology, Metabolism, Nutrition and Reproductive Sciences 9,5 367.780 2304945 Molecular biomarkers and cellular biosensors of neurodegeneration Brain Disorders and 9,5 600.000 2321968 CENTRAL EFFECTS OF BOTULINUM NEUROTOXINS: THERAPEUTIC IMPLICATIONS Toscana Brain Disorders and 9,5 300.000 2306890 Role of Calcium/Calmodulin dependent Kinase Kinase 2 in metabolic stress and inflammatory response SAN RAFFAELE PISANA Immunology 9,5 510.500 Pagina 28 di 142

2321735 Constitutive Axl signaling in human melanoma: role in tumor biology and in resistance to BRAFV600E inhibitors. ISTITUTO TUMORI MILANO Oncology 1 Basic 9,5 370.300 2307465 Expression of PARP1 and LDOC1 genes in subjects with Down syndrome and identification of new markers of neurodegenerative disorders in these subjects. OASI MARIA S.S. Interdisciplinary Molecular Sciences and Training 9,5 400.000 2318574 Synthesis of new compounds with antiret activity and evaluation of their antineoplastic activity (in vitro and in vivo) in papillary and medullary thyroid cancer Toscana Oncology 2 9,5 390.000 2314994 Neural Stem Cell mediated Therapy of Amyotrophic Lateral Sclerosis CASA SOLLIEVO SOFFERENZA Brain Disorders and 9,5 556.600 2319223 Adverse Health Effects of Airborne Particle Pollution: a multidisciplinary study IRCCS AOU San Martino IST (Genova) Population Sciences and Epidemiology 9,5 234.000 2313040 Use of protective cultures of lactic acid bacteria to control colonizing mastitis pathogens in the mammary gland of dairy small ruminants as an alternative to antibiotics Istituto Zooprofilattico Sperimentale della Sardegna Veterinary 9,5 400.000 2321561 Strategy of immunotherapy with specific T lymphocytes versus B cell acute lymphoblastic leukemia Piemonte Oncology 2 9,5 500.000 2320466 IDENTIFICATION OF PHENOTYPE MODULATOR VARIANTS IN LAMIN A/C MUTATION CARRIERS BY EXOME AND GENOME SEQUENCING Genes, Genomes and Genetics 9,5 492.000 2312484 Role of TIR8, a novel member of IL 1R/TLR family with a negative regulatory activity, in inflammation and cancer. HUMANITAS Immunology 9,5 400.000 2312933 Epigenetic memory and impairment of human endothelial and mesenchymal progenitor activity by cardiovascular risk factors MONZINO Cardiovascular and 9,5 595.900 2316600 Evaluation of a multidisciplinary team case management on clinical outcome in a tertiary traumatology centre. Toscana Healthcare Delivery and 9,5 360.000 Pagina 29 di 142

2312659 Effects of proton pump inhibitors on mortality and rehospitalization in older subjects : focus on the insulin like growth factor system and implications for health care system. Emilia Romagna Population Sciences and Epidemiology 9,5 156.500 2314841 Role of 18F FLT PET/CT in patients with suspect lymphoma relapse Emilia Romagna Oncology 2 9,5 160.000 2317292 Telemedicine Services for UTAP Veneto Healthcare Delivery and 9,5 574.999 2314903 Screening of children at risk for language and communication disorders Lazio Biobehavioral and Behavioral Processes 9,5 400.000 2312910 Validation of molecular signatures in liver lesions as paradigm for discovery of new biomarkers and therapeutic targets PASCALE Oncology 2 9,5 587.000 2317320 Soluble biomarkers predicting coronary bypass graft patency MONZINO Surgical Sciences, Biomedical Imaging, and Bioengineering 9,5 427.900 2311282 EFFECTS OF LESIONS OF PARIETAL AND FRONTAL CORTEX ON BOTTOM UP FEATURE DETECTION IN THE HUMAN VISUAL CORTEX: NICAL/REHABILITATIVE IMPLICATIONS FOR DISORDERS OF SPATIAL ATTENTION IN STROKE PATIENTS SANTA LUCIA Brain Disorders and 9,5 311.600 2318620 Optimizing and integrating the delivery of primary care services for risky drinkers in Region Friuli Venezia Giulia Friuli Venezia Giulia Healthcare Delivery and 9,5 175.000 2311299 Optimization of the clinical management of endocrineresponsive early breast cancer patients IRCCS AOU San Martino IST (Genova) Oncology 2 9,5 495.000 2312646 Pathway Dissection In Leukocyte Migration: Identification And Validation Of Novel Therapeutic Targets In Nonresolving Inflammation Immunology 9,5 562.000 Pagina 30 di 142

2321019 Disease related biomarkers investigation in Multiple sclerosis by analysis of microvesicles isolated by CSF. Sicilia Molecular, Cellular, and Developmental 9,5 270.000 2318774 Identification of prognostic and predictive serum biomarkers for monitoring type 1 diabetes risk and progression in humans Toscana Immunology 9,5 600.000 2315207 Necdin role in myogenic stem cells self renewal and maintenance for the repair of the dystrophic muscle Musculoskeletal, Oral and Skin Sciences 9,5 300.000 2316964 Functional significance of manipulating endogenous neurogenesis for nigrostriatal dopaminergic neuroprotection/neurorepair in murine models of Parkinson s disease: focus on neuroinflammation OASI MARIA S.S. Brain Disorders and 9,5 200.000 2318525 A comprehensive strategy to eradicate prion diseases from the Italian sheep and goat population Istituto Zooprofilattico Sperimentale della Sicilia Veterinary 9,5 579.700 2318000 The key role of serotonin in the pathophysiology of phenylketonuria: from bench to bedside OASI MARIA S.S. Brain Disorders and 9,5 600.000 2309087 Oxidative stress and microrna 125b : from molecular mechanisms to therapeutic implications in Hailey Hailey disease Istituto Superiore di Sanita' Musculoskeletal, Oral and Skin Sciences 9,5 495.000 2321996 TISSUE PATCH ENGINEERING OF ADIPOSE DERIVED STEM CELLS FOR MEDICAL DEVICES. MAGGIORE Bioengineering Sciences and Technologies 9,5 478.000 2306918 HUMAN ADIPOSE STEM CELLS AS A NOVEL TARGET FOR THERAPEUTIC INTERVENTION IN OBESITY Toscana Endocrinology, Metabolism, Nutrition and Reproductive Sciences 9,5 580.000 2316659 Perturbed hydrogen sulphide content in Amyotrophic Lateral Sclerosis: a possible player in motor neurons degeneration? SANTA LUCIA Brain Disorders and 9,5 440.000 2311519 DEFINING INNOVATIVE TREATMENT STRATEGIES FOR OSTEOSARCOMA BASED ON THE INHIBITION OF ABC TRANSPORTERS AND PROTEIN KINASES RIZZOLI Oncology 2 9,5 330.000 Pagina 31 di 142

2309400 Corrected ipsc as therapeutic source for Spinal Muscular Atrophy MAGGIORE Molecular, Cellular, and Developmental 9,5 348.000 2319503 THE USE OF MRI DERIVED MARKERS TO EARLY PREDICT CONSCIOUSNESS RECOVERY INCOMATOSE PATIENTS Lombardia Brain Disorders and 9,5 224.000 2308141 EXTENDING COMPREHENSIVE CANCER CENTERS EXPERTISE IN PATIENT EDUCATION: THE POWER OF PARTNERSHIP WITH PATIENT REPRESENTATIVES C.R.O. AVIANO Healthcare Delivery and 9,6 290.000 2318198 Prognostic marker of cytomegalovirus infection and transmission in pregnancy. Emilia Romagna Infectious Diseases and Microbiology 9,67 250.000 2311041 ACTION OBSERVATION TREATMENT (AOT) IN MILD ALZHEIMER DISEASE: A RANDOMIZED CONTROLLED TRIAL. Emilia Romagna Brain Disorders and 9,75 150.778 2318891 Vitamin D and Myasthenia Gravis: from the animal model to the human disease CARLO BESTA Brain Disorders and 9,75 255.500 2321248 Application of nanomechanical assays to detection of algal toxins Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia Veterinary 9,75 380.000 2305532 A study on molecular characteristics of the gp120 Env protein from HIV 1 subtypes and recombinant forms circulating in Cameroon and their correlation with disease stage, virus infectivity and resistance to neutralization Istituto Superiore di Sanita' AIDS and Related Research 9,75 550.000 2309175 Efficacy of re treatment with anti TNF biologics in patients with psoriasis who have been previously treated with the same biological drug SAN GALLICANO Musculoskeletal, Oral and Skin Sciences 10 420.000 2321154 HOME BASED COGNITIVE REHABILITATION AFTER BRAIN DAMAGE THROUGH VIRTUAL REALITY Lombardia Brain Disorders and 10 549.776 Pagina 32 di 142

2321532 MicroRNAs as potential therapeutic strategies to prevent adverse vascular events and increase angiogenesis after limb ischemia. Calabria Cardiovascular and 10 282.000 2309827 The clinical significance of the association between REM Sleep Behavior Disorder and Parkinson s Disease OASI MARIA S.S. Brain Disorders and 10 350.000 2315404 EFFECT OF DEACETILASE INHIBITORS ON EPIGENETIC BALANCE OF E CADHERIN: NEW TOOLS TO CONTROL LOCAL INVASION AND METASTASIS OF ENDOCRINE RELATED TUMORS Piemonte Oncology 1 Basic 10 150.000 2304029 Risk of obstetric and thromboembolic complications in family members of women with previous adverse obstetric outcomes carrying inherited thombophilias. A family study CASA SOLLIEVO SOFFERENZA Population Sciences and Epidemiology 10 150.000 2308949 Aphasia. Theory for therapy. Therapy for theory. S.CAMILLO Brain Disorders and 10 290.000 2313013 The modulation of T helper cell death as therapeutic approach to reduce the pathogenic cells in Multiple Sclerosis (MS). SANTA LUCIA Brain Disorders and 10 420.000 2303599 Non invasive diagnosis on non alcoholic steatohepatitis and of significant/severe fibrosis among patients with non alcoholic fatty liver disease. Sicilia Digestive, Kidney and Urological Systems 10 150.000 2321487 Autoimmune encephalopaties: better characterization of the antibody profile CARLO BESTA Brain Disorders and 10 297.200 2319384 Developing innovative methods for detecting emerging food allergens and evaluation of their impact on consumer health: an integrated approach.integrall Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta Veterinary 10 580.000 2312281 Biomarkers and prognostic factors in psoriasis and psoriatic arthritis: a prospective cohort study Lombardia Musculoskeletal, Oral and Skin Sciences 10 200.000 2317872 Telemedicine in cardiology:training of a virtual team SAN RAFFAELE PISANA Healthcare Delivery and 10 165.000 Pagina 33 di 142

2313702 Impact of diet in shaping gut microbiota revealed by a prospective dietetic study of African children consuming a Western diet DE BELLIS Endocrinology, Metabolism, Nutrition and Reproductive Sciences 10 202.500 2314482 RESPONSE ORIENTED MAINTENANCE IMMUNOTHERAPY IN PATIENTS WITH FOLLICULAR LYMPHOMA. Emilia Romagna Oncology 2 10 600.000 2315054 Identification of early neurophysiological markers of cognitive behavioural disturbances in patients with cerebrovascular disease. Sicilia Brain Disorders and 10 200.000 2311159 EMERGING NOROVIRUS MUTANT AND RECOMBINANT STRAINS: A MOLECULAR EPIDEMIOLOGICAL INVESTIGATION ON SEWER SYSTEMS AND HOSPITALIZED PATIENTS Istituto Superiore di Sanita' Infectious Diseases and Microbiology 10 250.000 2317533 AUTOLOGOUS BONE MARROW DERIVED STEM CELL TRANSPLANTATION FOR TREATMENT OF CHRONIC END STAGE LIVER DISEASE (ESLD) Emilia Romagna Digestive, Kidney and Urological Systems 10 400.000 2315445 Phenotypes in Dislexia with genetic alteration: sensory and neuronal deficits STELLA MARIS Integrative, Functional, and Cognitive 10 165.000 2310012 Structural and functional large scale brain networks across multiple sclerosis clinical phenotypes: a graph theory approach to identify neuronal system vulnerability as a target of future therapeutic interventions Brain Disorders and 10 600.000 2308445 Implementation of a fracture liaison service for the identification, evaluation and management of patients with osteoporotic fractures Toscana Healthcare Delivery and 10 360.000 2319509 Etiopathogenetic, diagnostic and prognostic role of hypermethylation and downregulation of IRX1 gene inducedby H. pylori infection in patients with gastric cancer. Oncology 2 10 312.775 Pagina 34 di 142

2310424 HPV INFECTION IN A COHORT OF HIV POSITIVE MEN AND WOMEN: VIRO IMMUNOLOGICAL CORRELATES OF HPV DISEASE PROGRESSION AT GENITAL AND ORAL SITES Lombardia AIDS and Related Research 10 137.564 2316322 Role of functional and morphological MRI in the study of thalamus and auditory cortex for the assessment of the neurocognitive and clinical outcomes of premature newborns Brain Disorders and 10 250.000 2313804 Preemptive donor lymphocyte infusions guided by realtime PCR host donor microchimerism for prevention of leukemia relapse after haploidentical stem cell transplantation Oncology 2 10 500.000 2308024 Amelioration of diagnosis and therapy of steroid resistant nephrotic syndrome: a novel treatment approach by umbilical cord blood mesenchymal stem cells. MAGGIORE Digestive, Kidney and Urological Systems 10 250.000 2319584 Amniotic stem cells to improve congenital kidney damage: a fetal lamb model SAN MATTEO Digestive, Kidney and Urological Systems 10 400.000 2316632 TIPS FOR DECOMPENSATED CIRRHOSIS: A RANDOMIZED NICAL TRIAL Sicilia Surgical Sciences, Biomedical Imaging, and Bioengineering 10 443.000 2303378 Novel formula milks and neonatal gut microbiota: a dynamic interplay approached by systems biology OSPEDALE BAMBINO GESU' Endocrinology, Metabolism, Nutrition and Reproductive Sciences 10 523.000 2310395 Target definition of tumors in positron emission tomography: development and validation of a software tool to be installed on radiotherapy treatment planning systems Piemonte Oncology 2 10 250.000 2312166 Validation of the micronucleus assay in buccal exfoliated cells as a tool for biomonitoring DNA damage in human populations and predicting cancer, cardiovascular diseases and neurodegenerative disorders in healthy subjects. SAN RAFFAELE PISANA Population Sciences and Epidemiology 10 394.000 Pagina 35 di 142

2312033 SMALL PEPTIDES AS A NEW STRATEGY FOR THE THERAPY OF CELIAC DISEASE Istituto Superiore di Sanita' Digestive, Kidney and Urological Systems 10 450.000 2308150 2308140 Short and long term effects of ART in restoring intestinal mucosal immunity and reducing systemic immune activation in HIV infected patients. WHOLE EXOME SEQUENCING TO IMPROVE DIAGNOSTIC, PROGNOSTIC AND LOGICAL CHARACTERIZATION OF AML WITH NORMAL KARYOTYPE Istituto Superiore di Sanita' AIDS and Related Research 10 420.000 Umbria Vascular and Hematology 10 600.000 2314705 Can epilepsy affect the structure of the brain? Role of neurons and glia and effect of therapy in a model of epileptogenic brain malformation CARLO BESTA Brain Disorders and 10 575.000 2311409 WNT signaling in the pathogenesis and treatment of Bipolar Disorder Brain Disorders and 10 528.000 2312270 Preclinical characterization of a potent antimicrobial peptide for the development of a new drug for Cystic Fibrosis Toscana Infectious Diseases and Microbiology 10 250.000 2314110 Adoptive therapy with tolerogenic T regulatory type 1 (Tr1) cells in islet transplanted T1D patients Immunology 10 600.000 2303391 In vivo identification of molecular determinants critical to the metastatic process in melanoma I.E.O. Oncology 1 Basic 10 400.000 2315336 Increased severity of repiratory viral infections in the elderly: identification of thiol levels as biomarker and therapeutic target. SAN RAFFAELE PISANA Infectious Diseases and Microbiology 10 600.000 2306199 NOVEL AND SELECTIVE ANTI TUMOR STRATEGIES FOR THE TREATMENT OF GLIOMA ISTITUTO DERMOPATICO DELL'IMMACOLATA Brain Disorders and 10 330.000 2317020 Imaging and radioimmunotherapy of pancreatic cancer I. O. V. Surgical Sciences, Biomedical Imaging, and Bioengineering 10 539.900 Pagina 36 di 142

2313917 Hypothesized points of convergence in the pathogenesis of Alzheimer's disease, frontotemporal lobar dementia, schizophrenia and bipolar disorder with therapeutic implications Brain Disorders and 10 600.000 2309152 Pentraxin 3 as a predictive biomarker of hemorrhagic transformation following acute stroke NEUROMED Brain Disorders and 10 300.000 2320516 MicroRNAs as molecular markers of susceptibility to Mycobacterium tuberculosis infection and responsiveness to vaccination in IRF 8 deficient mouse model Istituto Superiore di Sanita' Infectious Diseases and Microbiology 10 594.000 2305497 In vivo analysis of the interactions between exogenouly administred mesenchymal stromal cells and primary acute leukemia cells or leukemia initiating cells growing in NOG mice: implications for selective delivery of anticancer drugs to leukemic niches GASLINI Oncology 1 Basic 10 450.000 2305558 Evaluation of oxidative stress and inflammation in blood as possible non invasive markers for progression of alcoholic liver disease. IRCCS AOU San Martino IST (Genova) Digestive, Kidney and Urological Systems 10 280.000 2306967 GENETIC REGULATION OF PLASMA LOW DENSITY LIPOPROTEIN LEVELS.EFFECT OF MUTATIONS OF APOB AND ANGPTL3 GENES ON HEPATIC SECRETION OF APOB CONTAINING LIPOPROTEINS. Emilia Romagna Cardiovascular and 10 380.000 2301285 Steroid myopathy: pathogenies and prevention MAUGERI Musculoskeletal, Oral and Skin Sciences 10 300.000 2315654 How innate immunity enhances aggressiveness of colorectal carcinoma in HIV individuals AIDS and Related Research 10 500.000 2301643 Pre clinical evaluation of safety and efficacy of intraarterial infusion of mesenchymal stems cells in experimental models of neurodegenerative parkinsonisms and analysis of potential therapeutic mechanisms: en route for a clinical trial MONDINO Brain Disorders and 10 595.000 2301319 A new therapeutic window in neurorehabilitation FATEBENEFRATELLI Biobehavioral and Behavioral Processes 10 572.500 Pagina 37 di 142

2312031 Cell stress mediators in cancer stroma interaction as targets for drug development SDN Oncology 1 Basic 10 368.000 2312634 mirna driven conditional attenuation of viral vaccines Infectious Diseases and Microbiology 10 600.000 2319631 Targeting Hedgehog and Colony Stimulating Factor 1 pathways in triple negative breast cancers Toscana Oncology 2 10 600.000 2320716 Innovative procedures for Transcranial Magnetic Stimulation of neuro patients, also in vegetative state NEUROLESI Surgical Sciences, Biomedical Imaging, and Bioengineering 10 317.000 2317950 Heart remodelling in Chronic Obstructive Pulmonary Disease: diagnostic and therapeutic implications Emilia Romagna Cardiovascular and 10 210.100 2313612 Thematic network on Bovine Diarrhoea Virus (BVDV) to improve tools and strategies for BVDV control in Italy Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche Veterinary 10 520.000 2321548 Use of polydeoxyribonucleotide for treating diabetic foot ulcers Sicilia Endocrinology, Metabolism, Nutrition and Reproductive Sciences 10,17 350.000 2319585 Prevalence of Neonatal Adverse Outcomes and Their Risk Factors and Study on Adverse Medication Effects on the Newborn Health. Veneto Endocrinology, Metabolism, Nutrition and Reproductive Sciences 10,25 329.000 2317095 Assessing antibiotic resistance in nonpathogenic foodrelated bacteria: the impact on human gut microbiota Istituto Zooprofilattico Sperimentale delle Venezie Veterinary 10,25 558.600 2310899 Campylobacter, L. monocytogenes and Verocytotoxinproducing E. coli (VTEC) in Italy: a molecular epidemiology approach to identify sources of infection and risk factors for human exposure Istituto Zooprofilattico Sperimentale dell'abruzzo e del Molise Veterinary 10,25 580.000 2320021 Human Cytomegalovirus (HCMV) specific T cell immunity monitoring and inflammatory response analysis in solid organ transplant recipients: from pathogenesis to clinical application Toscana Infectious Diseases and Microbiology 10,25 289.000 Pagina 38 di 142

2314617 Studying the tumour microenvironment to find new therapeutic targets and strategies in Hodgkin lymphoma: the role of Mesenchymal stem cells C.R.O. AVIANO Oncology 1 Basic 10,25 310.000 2312117 Allergy management based on the neonatal risk: a technological pathway. SAN MATTEO Risk, Prevention and Health Behavior 10,25 325.000 2318550 SERUM AUTOANTIBODIES TO LGI1 AND OTHER CELL SURFACE MEMBRANE PROTEINS IN TEMPORAL LOBE EPILEPSIES OF OTHERWISE UNKNOWN AETIOLOGY Istituto Scienze Neurologiche Brain Disorders and 10,25 300.000 2317164 Prospective multicenter study on the efficacy of a new, taylored on risk class, antibiotic prophylaxis protocol in preventing neurosurgical Surgical Site Infection (SSIs). Lombardia Infectious Diseases and Microbiology 10,25 150.000 2309944 Urine proteome analysis: A possible method that may allow noninvasive differential diagnosis of diabetic nephropathy and give new insight into monogenic type 2 diabetes. OSPEDALE BAMBINO GESU' Digestive, Kidney and Urological Systems 10,34 352.000 2312867 New methodologies for non invasive, quantitative and Automatic MOnitoring of childbirth LABor (AMOLAB) Puglia Surgical Sciences, Biomedical Imaging, and Bioengineering 10,34 597.000 2318665 Proposal for a multidisciplinary integrated approach to the health management of myotonic dystrophy type 1 (DM1) SAN RAFFAELE PISANA Healthcare Delivery and 10,34 450.000 2317929 The effect of pulmonary rehabilitation on the reduction of acute exacerbations in patients with COPD. The impact of inflammatory phenotype DON GNOCCHI Cardiovascular and 10,34 387.000 2305898 Role of Toll like receptors in chemoresistance of chronic lymphocytic leukemia Immunology 10,5 225.000 2319479 Role of Innate Immunity, Inflammasome and RAAS in the progression of type 2 diabetes through the regulation of hepatic, cardiovascular and endothelial function Lazio Endocrinology, Metabolism, Nutrition and Reproductive Sciences 10,5 600.000 Pagina 39 di 142

2315771 Validation in genetic mouse models and in human cells of two gene therapy approaches against striatal degeneration and Huntington's Disease Brain Disorders and 10,5 600.000 2320778 In vitro and in vivo effects of post transplant cyclophosphamide as novel immunosuppressive regimen for hematopoietic stem cell transplantation from partially HLA matched donors IRCCS AOU San Martino IST (Genova) Immunology 10,5 600.000 2311910 Localizing the epileptogenic zone in presurgical evaluation of drug resistant focal epilepsies: a complex network based approach CARLO BESTA Surgical Sciences, Biomedical Imaging, and Bioengineering 10,5 548.000 2310496 Comparative analysis of the leukemia associated fusion proteins TEL/AML1 and AML1/ETO. I.E.O. Vascular and Hematology 10,5 362.000 2311337 Simultaneous inhibition of PARP and homologous recombination: a new hypothesis for radiosensitization ONCOLOGICO DI BARI Oncology 2 10,5 337.050 2309909 Pathogenesis of bone alterations in chronic liver diseases: study and identification of cellular and molecular mechanisms. AUXOLOGICO Musculoskeletal, Oral and Skin Sciences 10,5 462.000 2306592 The adenosine receptors: potential targets for diagnosis, prognosis and therapy of cancer Emilia Romagna Oncology 2 10,5 300.000 2310774 IN VITRO GENERATION OF HEMOGENIC ENDOTHELIUM FROM HUMAN CORD BLOOD: A NEW TOOL FOR STUDYING THE DEVELOPMENT OF THE HEMATOPOIETIC SYSTEM AND FOR REGENERATIVE MEDICINE Istituto Superiore di Sanita' Cell Biology 10,5 200.000 2304956 Macrophage polarization and HIV infection. A model of multiple restrictions of the virus life cycle. AIDS and Related Research 10,5 300.000 2303474 Insight into molecular events involved in the cooperation between bcl 2/bcl xl and hypoxia in the regulation of tumor progression and angiogenesis REGINA ELENA Oncology 1 Basic 10,5 380.000 2319680 Investigation of a novel engineered probiotic to treat Clostridium difficile infection Infectious Diseases and Microbiology 10,5 390.000 Pagina 40 di 142

2312242 Development of an exosome based in vivo test to detect prions in blood Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta Molecular, Cellular, and Developmental 10,5 480.000 2308054 Study of the P2RX7 gene coding the purinergic P2X7 receptor for extracellular ATP, as a susceptibility marker for Amyotrophic Lateral Sclerosis: genetic and functional analysis of polymorphisms identified in a cohort of ALS patients. SANTA LUCIA Brain Disorders and 10,5 506.000 2312313 Treatment of Neurological Impairment in Lysosomal StorageDiseases by the Use of Neural Stem Cells CASA SOLLIEVO SOFFERENZA Molecular, Cellular, and Developmental 10,5 461.000 2313247 Antimicrobial Microbubbles (MBs) for treatment of biofilm associated infections. Istituto Superiore di Sanita' Bioengineering Sciences and Technologies 10,5 600.000 2316572 EXOME RESEQUENCING IN UNEXPLAINED RARE BLEEDING DISORDERS MAGGIORE Genes, Genomes and Genetics 10,5 300.000 2313672 NEW MOLECULES AS DISEASE MODIFYING DRUGS FOR OSTEOARTHRITIS TREATMENT Istituto Superiore di Sanita' Musculoskeletal, Oral and Skin Sciences 10,5 350.000 2319224 Neurobiological, pharmacological and clinical studies on Attention Deficit Hyperactivity Disorder (ADHD): from patients to animal models and back. STELLA MARIS Brain Disorders and 10,5 600.000 2304391 Patient specific Induced Pluripotent Stem Cells (ipscs) to model neurodegeneration and to test gene therapy approaches in Lysosomal Storage Disorders (LSDs). Genes, Genomes and Genetics 10,5 275.000 2319841 THE ROLE OF SOD1 IN THE NUCLEUS: NEW INSIGHTS INTO THE PATHOGENESIS OF AMYOTROPHIC LATERAL SCLEROSIS MONDINO Molecular, Cellular, and Developmental 10,5 230.000 2307938 Structural analysis of nucleophosmin as a target for acute myeloid leukemia treatment Abruzzo Biological Chemistry and Macromolecular Biophysics 10,5 210.000 Pagina 41 di 142

2311608 An integrated analytical, in vivo and in vitro approach to characterize polybrominated diphenyl ethers (PBDEs) in italian mussels: a basis for a Toxic Equivalent Factors (TEF) proposal. Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche Veterinary 10,5 366.000 2320090 Enhanced cell therapy: novel strategies to improve transplanted cell survival and engraftment by protection from oxidative stress OSPEDALE BAMBINO GESU' Vascular and Hematology 10,5 570.000 2320514 A cooperative translational study focused on inflammation and eicosanoids to identify mechanism and predictors of preeclampsia Veneto Endocrinology, Metabolism, Nutrition and Reproductive Sciences 10,5 550.000 2320685 Study on the Mammalian Target of Rapamycin (mtor) signaling pathway as a potential antiepileptogenic therapy Calabria Brain Disorders and 10,5 460.000 2320235 GLIAL FIBRILLARY ACIDIC PROTEIN (GFAP) LEVELS AS A DRUGGABLE TARGET TO DEVELOP A PHARMACOLOGICAL STRATEGY IN ALEXANDER DISEASE GASLINI Genes, Genomes and Genetics 10,5 380.000 2318521 Expression of estrogen receptors and neuroglobin as a new tool to assess stratification of Parkinson's disease patients Piemonte Brain Disorders and 10,5 500.000 2315184 Molecular determination of Salmonella serovars by using microsphere based suspension array Istituto Zooprofilattico Sperimentale delle Venezie Veterinary 10,5 274.200 2321516 Combination of carfilzomib and pomalidomide, two last generation proteasome inhibitor and immunomodulating agents, for the treatment of patients with multiple myeloma relapsed after or refractory to lenalidomide: an international (EMNTG) phase I II clin CROB Oncology 2 10,5 450.000 2319990 System biology approach to define etiology and pathogenesis of idiopathic non histaminergic angioedema with normal C1 inhibitor Lombardia Genes, Genomes and Genetics 10,5 560.000 Pagina 42 di 142

2308638 HUMANS AND WILDLIFE: ZOOS IN BETWEEN. ARE ZOOS A THREAT OR SENTINELS FOR INFECTIOUS DISEASES? Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta Veterinary 10,5 410.586 2321103 Prof of Concept combination strategy for HIV prevention and control: does microbicide during vaccination impact on B cell immune responses? AIDS and Related Research 10,5 553.960 2311255 Chronic kidney disease and cardiovascular risk in Italy. A population based longitudinal study exploiting the CNESPS ISS biological specimen bank Istituto Superiore di Sanita' Population Sciences and Epidemiology 10,5 562.000 2315406 Striatal synaptic plasticity in experimental models of Parkinson's disease with different degrees of dopamine denervation: molecular mechanisms and therapeutics implications SANTA LUCIA Brain Disorders and 10,5 490.000 2314384 PRENICAL DEVELOPMENT OF NOVEL SMALL ANDROGEN RECEPTOR MODULATING MOLECULES (SARMS) IN EXPERIMENTAL HUMAN PROSTATE CANCER MODELS Emilia Romagna Oncology 2 10,5 600.000 2314786 AN INNERVATED TISSUE ENGINEERING APPROACH TO RECONSTRUCT THE ESOPHAGUS Veneto Surgical Sciences, Biomedical Imaging, and Bioengineering 10,5 296.955 2315821 Prognostic and Predictive microrna Biomarkers in Sarcoma C.R.O. AVIANO Oncology 2 10,5 400.000 2318228 Pathogenetic role and potential clinical exploitation of the CCL2/CCR2 axis in the regulation of immune responses in ALS HUMANITAS Immunology 10,5 485.000 2316441 Validation of a prognostic multigene classifier for larynx carcinoma, application to fine needle biopsies and functional analyses of classifier genes IRCCS AOU San Martino IST (Genova) Oncology 2 10,5 240.000 2314187 IMPLEMENTATION AND TESTING OF AN E HEALTH BASED SYSTEM FOR EARLY DIAGNOSIS AND INTERVENTION ON SPECIFIC READING DISORDERS MEDEA Healthcare Delivery and 10,5 250.000 Pagina 43 di 142

2316981 Genetic and antigenic diversity and pathogenicity of viruses associated with enteritis. Emilia Romagna Infectious Diseases and Microbiology 10,5 599.444 2317295 Fast tracking of proximal femur fractures: evaluation of the efficacy by means of quantitative neuromotor conditions assessment at mid time follow up. RIZZOLI Surgical Sciences, Biomedical Imaging, and Bioengineering 10,5 420.000 2318328 Determinants of functional recovery in elderly hip fracture subjects admitted to orthogeriatric units: a multicentre observational study. ARCISPEDALE Healthcare Delivery and 10,5 467.500 2315778 Bilateral sequential lung and pancreas transplantation and combined en bloc liver pancreas transplantation in patients with cystic fibrosis Lombardia Surgical Sciences, Biomedical Imaging, and Bioengineering 10,5 261.500 2320880 A study on the economic and social burden of Parkinson s Disease in Italy and a cost benefit analysis of disease modifying therapies. SAN RAFFAELE PISANA Healthcare Delivery and 10,5 320.000 2312394 Pilot study of a combination of an mtor inhibitor (everolimus) and capecitabine administered with a metronomic schedule in patients undergoing liver transplantation for hepatocellular carcinoma at high risk of recurrence. Emilia Romagna Oncology 2 10,5 260.000 2314044 alpha7 nachr status and response to donepezil in AD patients SAN RAFFAELE PISANA Brain Disorders and 10,5 600.000 2316411 TELE PHYSICO TELEMEDICINE FOR PHYSICAL HEALTH PROMOTION IN TREATED PSYCHIATRIC PATIENTS WITH FUNCTIONAL PSYCHOSES. A multicentre randomised controlled trial. FATEBENEFRATELLI Risk, Prevention and Health Behavior 10,5 499.500 2321091 Governance of diabetes management in non specialistic hospital settings. Emilia Romagna Healthcare Delivery and 10,5 555.889 2312560 Telemonitoring in Heart Failure Liguria Bioengineering Sciences and Technologies 10,5 255.500 Pagina 44 di 142

2317835 Prognostic role of serum pro PSA, circulating tumor cells and serum testosterone levels in prostate cancer patients with biochemical progression undergoing androgen deprivation therapy Piemonte Oncology 2 10,5 220.000 2312563 EXPERIMENTAL EVIDENCES ON POSSIBLE TOXIC EFFECTS OF LEVODOPA ON MAMMALIAN SUBSTANTIA NIGRA DOPAMINERGIC NEURONS SANTA LUCIA Brain Disorders and 10,75 396.000 2321867 EVALUATION OF THE ROLE OF HPV INDUCED IMMUNE RESPONSE IN VACCINE RELATED EFFICACY: COMPARISON BETWEEN BIVALENT AND QUADRIVALENT HPV VACCINES IN FEMALES AND MALES MAGGIORE Risk, Prevention and Health Behavior 10,75 350.000 2314560 Staphylococcal enterotoxin in traditional raw ewe milk Pecorino cheese: risk assessment and proteomic characterization Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche Veterinary 10,75 360.000 2312103 TRAIN: Training through Research Application Italian initiative Istituto Superiore di Sanita' Interdisciplinary Molecular Sciences and Training 11 600.000 2308349 Exploiting the therapeutic and prognostic potential of micrornas in melanoma ISTITUTO DERMOPATICO DELL'IMMACOLATA Oncology 2 11 594.000 2320894 Glioblastoma multiforme long survivors: impact of molecular profile on prognosis Toscana Oncology 2 11 291.000 2317370 Allergens, chemical and biological contaminants in nursery and primary schools: a proposal of a multimethod approach for the assessment of the main risk pollutants Istituto Superiore di Sanita' Risk, Prevention and Health Behavior 11 570.000 2321650 New therapeutic strategies for the control of fungal infections in the elderly Istituto Superiore di Sanita' Infectious Diseases and Microbiology 11 600.000 2314973 Nanoparticle delivered gene therapy to overcome remyelination failure resulting from blocked mature oligodendrocytes in multiple sclerosis like disease CARLO BESTA Brain Disorders and 11 240.700 Pagina 45 di 142

2313565 Estimation of cured patients among persons living with neoplasms C.R.O. AVIANO Population Sciences and Epidemiology 11 161.000 2318948 Characterization of anal HPV infection and associated lesions in immunocompetent and immunocompromised hosts. SAN GALLICANO Oncology 1 Basic 11 518.900 2310854 Role of the ghrelin gene derived peptides and growth hormone releasing hormone (GHRH) on microrna expression and function in the heart Piemonte Cardiovascular and 11 371.000 2318158 Application of molecular techniques to identify zoonosis agents transmitted by arthropods. Istituto Zooprofilattico Sperimentale del Mezzogiorno Veterinary 11 600.000 2311056 The role of mirna in MYC regulatory network Toscana Oncology 1 Basic 11 308.000 2316064 IDENTIFYING CORRELATIONS BETWEEN GENOTYPES AND PHENOTYPES OF DENT'S DISEASE. PARTICIPATION TO THE INTERNATIONAL DENT S DISEASE REGISTRY Veneto Digestive, Kidney and Urological Systems 11 182.900 2312132 Development of novel drugs targeting protozoan agents of tropical diseases imported in Italy Istituto Superiore di Sanita' Infectious Diseases and Microbiology 11 563.310 2313253 Detection of pathological prion protein in cerebrospinal fluid by real time quaking induced conversion (QuIC): Evaluation and standardization of a novel disease specific laboratory test for the diagnosis of sporadic Creutzfeldt Jakob disease. Istituto Scienze Neurologiche Brain Disorders and 11 420.200 2310911 Common pathogenic pathways in Motor Neuron Diseases : a study on the relation between SMN and TLS/FUS SANTA LUCIA Molecular, Cellular, and Developmental 11 150.000 Pagina 46 di 142

2311059 MESOANGIOBLASTS FOR THE CELL THERAPY OF FACIOSCAPULOHUMERAL MUSCULAR DYSTROPHY (FSHD): EXPLORING SKELETAL MUSCLE DIFFERENTIATION OF FSHD MESOANGIOBLASTS IN VITRO AND IN VIVO IN SCID MICE AND IN A MOUSE MODEL OF FSHD. DON GNOCCHI Musculoskeletal, Oral and Skin Sciences 11 500.000 2312057 GENETIC DETERMINANTS OF LEFT VENTRICULAR HYPERTROPHY AUXOLOGICO Cardiovascular and 11 401.000 2307445 Exploiting the p53 p66shc signalling pathway to identify new molecular markers for the prevention of cancer and age related diseases I.E.O. Biology of Development and Aging 11 305.000 2312631 Low dose effects: in vivo models of chemotherapyradiation therapy interactions Emilia Romagna Oncology 2 11 600.000 2310171 ANTI INFLAMMATORY ACTIVITY OF POLYPHENOLS IN CANCERCHEMOPREVENTION: IN VITRO AND IN VIVO STUDIES Istituto Superiore di Sanita' Endocrinology, Metabolism, Nutrition and Reproductive Sciences 11 576.000 2310897 Immunesurveillance of leukemia by CD1 restricted T cells specific for self lipid antigens Immunology 11 430.000 2307246 Sp140 PHD finger as a potential target for chronic lymphocytic leukemia: a multidisciplinary approach Biological Chemistry and Macromolecular Biophysics 11 550.000 2302604 Role of IL 4 producing granulocytes in thymic stromal lymphopoietin dependent Th2 type inflammation in pancreatic cancer Immunology 11 375.000 2319902 gene environment and gene gene association analyses on cognitive phenotypes in Italian nuclear families of dyslexia MEDEA Brain Disorders and 11 254.000 2304412 Unraveling the molecular basis of neurodegeneration in frontotemporal lobar degeneration : role of genome instability associated with tau mutations CARLO BESTA Brain Disorders and 11 299.950 2307307 Safety and efficacy of infusion of human adipose derived mesenchymal cells in experimental models of whole and partial liver transplantation in large size animals. Emilia Romagna Digestive, Kidney and Urological Systems 11 579.425 Pagina 47 di 142

2308082 LOGICAL APPROACH TO DECONTAMINATION OF BIVALVE MOLLUSCS FROM V.PARAHAEMOLYTICUS AND SALMONELLA BY MARINE BDELLOVIBRIO AND LIKE ORGANISMS (BALOs) Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche Veterinary 11 250.000 2307049 Perinatal stress in human and non human offspring: a translational approach to study epigenetic impact on depression. Istituto Superiore di Sanita' Biobehavioral and Behavioral Processes 11 560.000 2305813 Evaluation of Opisthorchis felineus metacercariae infectivity after fish fillets freezing at different timetemperature combinations. Istituto Zooprofilattico Sperimentale del Lazio e della Toscana Veterinary 11 150.600 2314968 Genetic polymorphisms and noninvasive scores for screening patients with progressive non alcoholic fatty liver disease (NAFLD): an international multicenter collaborative study Piemonte Digestive, Kidney and Urological Systems 11 150.000 2316947 Study of basic and clinical aspects of mitotane treatment in patients with adrenocortical carcinoma. Piemonte Oncology 2 11 250.000 2317573 Quantitative evaluation of the function of the elbow operated through inertial devices RIZZOLI Musculoskeletal, Oral and Skin Sciences 11 441.600 2316163 Diagnostic impact of circulating mirna and cancer cells in poorly differentiated carcinomas of the lung and breast. Emilia Romagna Oncology 2 11 300.000 2316609 Prediction of preeclampsia:a proteomic approach for identification of novel biomarkers Istituto Superiore di Sanita' Endocrinology, Metabolism, Nutrition and Reproductive Sciences 11 411.000 2314345 VALIDATION OF NANOPARTICLES FOR DRUG DELIVERY IN HEREDITARY NEUROMUSCULAR DISEASES TREATMENTS OSPEDALE BAMBINO GESU' Molecular, Cellular, and Developmental 11 600.000 2312282 Disentangling prenatal and postnatal influences on infant bio behavioral development: a prospective study. MEDEA Biobehavioral and Behavioral Processes 11 401.300 Pagina 48 di 142

2314341 Identification of novel biomolecular targets of pets spontaneous carcinomas for the development of new diagnostic and therapeutics approaches: use of the human knowledge to accelerate the management of pets tumors. Istituto Zooprofilattico Sperimentale del Lazio e della Toscana Veterinary 11 350.000 2309826 ROLE OF MITOCHONDRIAL OXIDATIVE METABOLISM AND REDOX SIGNALING IN ADULT STEM CELL PROLIFERATION AND DIFFERENTIATION: DEVELOPMENT OF INNOVATIVE STRATEGIES FOR EX VIVO HEMATOPOIETIC STEM CELL EXPANSION TO BE USED IN ONCO HEMATOLOGICAL THERAPIES CROB Vascular and Hematology 11 200.000 2305885 GENOMIC VARIATION AND PROTEOMIC PROFILE IN NEONATAL BRONCOPULMONARY DYSPLASIA AND RESPIRATORY DISTRESS NICAL SPECTRUM Genes, Genomes and Genetics 11 594.000 2314513 ABCB1/P glycoprotein expression: a biological stratification of the risk in patients with non metastatic osteosarcoma of the extremity. An Italian Sarcoma Group prospective study (ISG/OS 2). Emilia Romagna Oncology 2 11 250.000 2308914 Hypothesis driven gene candidate study of copper involvement in the pathogenesis of Alzheimer s disease: detection of sequence changes, haplotype profile of ATP7B gene and their molecular and functional aspects SAN RAFFAELE PISANA Brain Disorders and 11 600.000 2316849 INVESTIGATING PROGRESSION FROM PRENEOPLASTIC TO NEOPLASTIC DISEASE IN ESOPHAGEAL AND PANCREATIC CANCER BY MEANS OF AN INTEGRATIVE GENOMICS NEXT GENERATION SEQUENCING BASED APPROACH. Digestive, Kidney and Urological Systems 11 300.000 2313227 Amantadine treatment for pathological gambling FATEBENEFRATELLI Brain Disorders and 11 600.000 2314014 DISCHARGE FROM FORENSIC MENTAL HOSPITALS, COMMUNITY TENURE, AND RISK OF RECIDIVISM: A PROSPECTIVE FOLLOW UP STUDY Lombardia Healthcare Delivery and 11 580.000 Pagina 49 di 142

2313141 Treatment optimization of recurrent glioblastoma Emilia Romagna Oncology 2 11 500.000 2317172 Person/Patient and Family centred care PCC & FCCUnderstanding health care experiences and perceptions of parents of hospitalized premature infants, children with a chronic condition and their parents and health professionals in South Tyrol and other reg Provincia autonoma Bolzano Healthcare Delivery and 11 477.475 2320690 HBV related chronic hepatitis: bone metabolism study in naïve patients and in long term therapy with nucleos(t)ide analogue Piemonte Digestive, Kidney and Urological Systems 11 150.000 2308935 Multicenter,Italian,randomized,open label,parallelgroup, non inferiority phase III clinical trial comparing cisplatin 5Fluorouracil cetuximab vs. carboplatinpaclitaxel cetuximab in recurrent/metastatic squamous cell carcinoma of the head and neck Lombardia Oncology 2 11 598.000 2311399 PREVENTION AND DIAGNOSIS OF FETAL ALCOHOL SYNDROME (FAS) AND FETAL ALCOHOL SPECTRUM DISORDER (FASD) AMONG ITALIAN REGIONS Lazio Risk, Prevention and Health Behavior 11 240.250 2317132 Effect of lower limb end effector robot assisted therapy with body weight support vs treadmill gait training in Parkinson Patients. SAN RAFFAELE PISANA Brain Disorders and 11 410.000 2321426 New paradigms for Tuberculosis (TB) management using rapid molecular detection of Mycobacterium tuberculosis and Rifampin resistance Emilia Romagna Infectious Diseases and Microbiology 11 2.275.000 2316804 Whole Exome sequencing a novel modality for diagnostics and disease gene discovery in Cardiomyopathies MULTIMEDICA Genes, Genomes and Genetics 11 455.550 2322049 An Italian multidisciplinary clinic for Wolfram Syndrome GASLINI Endocrinology, Metabolism, Nutrition and Reproductive Sciences 11 251.472 2318356 Role of acetylcholinesterase R in the treatment of Myastenia Gravis. SAN RAFFAELE PISANA Oncology 2 11 600.000 Pagina 50 di 142

2318405 Significance of Sentinel Node Micrometastasis in Breast Cancer Progression C.R.O. AVIANO Oncology 2 11 583.000 2321145 Multimodal evaluation of stroke patient's mindbrain state during upper limb robot aided therapy SAN RAFFAELE PISANA Emerging Technologies and Training in s 11 600.000 2317038 DEVELOPMENT OF A FULL WIRELESS POLYGRAPHIC DEVICE FOR DIAGNOSIS OF SLEEP DISORDERS AND REMOTELY ATTENDED HOME MONITORING AUXOLOGICO Emerging Technologies and Training in s 11 425.500 2320441 Integrated approach to the small fetus: how different patterns of fetal growth impact on neonatal morbidity and long term auxological, neurodevelopmental and metabolic outcomes Piemonte Risk, Prevention and Health Behavior 11 600.000 2312066 Efficacy of a neuromotor and cognitive behavioural training for disability, kinesiophobia and gait disturbances in chronic non specific low back pain MAUGERI Musculoskeletal, Oral and Skin Sciences 11 251.000 2300483 Assessment and management of cardiovascular risk in perimenopausal women undergoing breast cancer screening AUXOLOGICO Healthcare Delivery and 11 480.000 2310616 Biological nurturing and exclusive breastfeeding at 12 weeks: a randomised controlled trial BURLO GAROFALO Healthcare Delivery and 11 152.786 2318863 DEVELOPMENT OF A THYROID CANCER DATABASE TO IMPROVE THE QUALITY OF NICAL PRACTICE AND REDUCE PUBLIC HEALTH COSTS Lazio Oncology 2 11 590.000 2313378 Early integration of palliative care with standard oncologic care in advanced non small cell lung cancer. A prospective, multi center observational study to evaluate how this approach impact on patient s survival and quality of life with an additional ana I. O. V. Healthcare Delivery and 11 150.000 2303620 SENESCENCE ASSOCIATED micrornas (SAmiRs) IN CELLULAR SENESCENCE AND ORGANISMAL AGING SDN Biology of Development and Aging 11,25 400.000 Pagina 51 di 142

2311517 Proteomic signatures as biomarkers of breast cancer risk andas predictors of outcome in women with early breast cancer. IRCCS AOU San Martino IST (Genova) Oncology 2 11,25 350.000 2316285 Mobile genetic elements: new approaches to molecular epidemiology of antimicrobial resistance genes in Gramnegative clinical isolates Abruzzo Infectious Diseases and Microbiology 11,34 300.000 2315093 Therapeutic drug monitoring protocols for dose personalization of antibacterial agents administered to patients with severe Gram positive infections Toscana Healthcare Delivery and 11,5 135.000 2321798 Citicoline treatment for traumatic brain injury NEUROLESI Brain Disorders and 11,5 168.500 2321791 A randomized multi center study for the evaluation of efficacy and safety of two different daily doses of low molecular weight heparin (LMWH) in subjects with cancer and incidentally detected non symptomatic pulmonary embolism SAN MATTEO Cardiovascular and 11,5 390.000 2316818 Electronic Medical Record for PDD: A powerful tool for health care, clinical governance and epidemiological studies Istituto Superiore di Sanita' Healthcare Delivery and 11,5 252.000 2317270 Genotoxicity, biochemical and tissutal responses in aquatic organisms exposed to chlorpyrifos and deltamethrin, assessing their risk for animal and human health Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta Veterinary 11,5 576.400 2310910 Identification of signaling pathway activation profiles in cancer stem cells by mass cytometry, comparison with the reverse phase protein array approach and correlation with sensitivity to pathway targeting drugs. Istituto Superiore di Sanita' Oncology 1 Basic 11,5 400.000 2307175 Cotransplantation of pancreatic islets and engineered third party human umbilical cord mesenchymal stem cells. A novel approach to increase graft survival and immune tolerance in type 1 diabetes patients Toscana Endocrinology, Metabolism, Nutrition and Reproductive Sciences 11,5 425.000 Pagina 52 di 142

2308014 Cutaneous sensory and autonomic innervation in early parkinsonism. A new tool to predict clinical evolution toward PD, MSA and PSP. MAUGERI Brain Disorders and 11,5 300.000 2299313 Neurophysiological approach to evaluate cerebrocerebellar interactions. Characterization of a cerebellar connectivity EEG index. SANTA LUCIA Brain Disorders and 11,5 300.000 2312670 High throughput monitoring of pathogen specific cellular immunity as guidance for treatment of opportunistic infections in immunocompromised children. OSPEDALE BAMBINO GESU' Immunology 11,5 445.000 2321935 Individual risk in clinically isolated syndromes of conversion to multiple sclerosis and disease progression: an integrated public health clinical genomics approach Brain Disorders and 11,5 600.000 2320042 Targeting patients with recurrent depression and traumas: Comparison of the efficacy of EMDR and of CBT versus standard clinical management, their neurobiological correlates, and the associated health sanitary costs. Piemonte Biobehavioral and Behavioral Processes 11,5 189.000 2307180 A Pharmacogenomic Approach to Retinal Neuroprotection in Age Related Macular Degeneration. Lazio Cell Biology 11,5 78.500 2318997 Reducing the need for intensive care unit in hospitalized patients with early respiratory failure using the noninvasive ventilation technique. A multicentre randomized study. Surgical Sciences, Biomedical Imaging, and Bioengineering 11,5 550.000 2314460 Prospective Study on infectious complications in patients receiving biological drugs, either monoclonal antibodies or TNF alpha antagonists. Emilia Romagna Infectious Diseases and Microbiology 11,5 600.000 2318421 Virus associated tumors: identification of novel diagnostic, prognostic and treatment strategies SAN MATTEO Oncology 2 11,5 580.000 2321251 Health and equity effects of natural policy experiments in the fields of structural policies and health care organization Piemonte Healthcare Delivery and 11,5 180.000 Pagina 53 di 142

2319309 The treatment adherence in children and adolescents with Spina Bifida and neurogenic bladder: relations with demographic, medical, occupational, cognitive and psycho social variables. Lombardia Healthcare Delivery and 11,5 452.000 2318794 and healthcare strategies for improving quality of life in persons affected by spinal cord injuries: Tuscany regional network and use of innovative technological devices Toscana Musculoskeletal, Oral and Skin Sciences 11,5 258.800 2316155 ZnO nanoparticles as selective killers of liver metastasis derived from colon cancer SAN MATTEO Bioengineering Sciences and Technologies 11,5 380.000 2320180 IDENTIFICATION OF MOLECULAR MECHANISMS INVOLVED IN SYNOVIAL OSTEOCHONDROMATOSIS PATHOGENESIS Toscana Musculoskeletal, Oral and Skin Sciences 11,5 495.500 2321811 Molecular analysis of Streptococcus pneumoniae and Neisseria meningitidis serotypes/serogroups and potential coverage of available vaccines Toscana Immunology 11,5 240.000 2314304 Development of innovative rapid screening methods of corticosteroids agents in cattle as growth promoters using MEA and an enhanced histopathological approach Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta Veterinary 11,5 452.000 2319723 and Molecular aspects of Sunitinib related hyperlipidemia. Toscana Oncology 2 11,5 225.500 2319881 Effect of exposure to environmental and food contaminants, on bone and liver diseases. Istituto Zooprofilattico Sperimentale del Mezzogiorno Veterinary 11,5 600.000 2321455 Brain Tumor Banking: a tool for research, diagnosis and therapy MONDINO Oncology 1 Basic 11,5 525.000 2316833 Masked mycotoxins in cereal based food products. Analytical methods, evaluation of their occurrence and risk assessment: an emerging issue for food safety? Istituto Zooprofilattico Sperimentale delle Venezie Veterinary 11,5 533.000 Pagina 54 di 142

2317279 Role of CREB protein family members in human lymphoid malignancies Abruzzo Cell Biology 11,5 274.369 2318117 Protective role of high density of tumor associated macrophages in stage III colorectal cancer HUMANITAS Oncology 2 11,5 411.000 2319525 GENE EXPRESSION PROFILING IN HUMAN ACTH SECRETING PITUITARY TUMORS IN ASSOCIATION WITH NICAL AND CHEMICAL FEATURES. AUXOLOGICO Endocrinology, Metabolism, Nutrition and Reproductive Sciences 11,5 300.000 2312246 Cell characterization and analysis of the proliferative/differentiative potential of human coelomic fluid cells for "in utero" haematopoietic stem cell transplantation in haemoglobinopathies Sicilia Vascular and Hematology 11,5 390.000 2311132 Viral respiratory infections in intensive care patients. Toscana Infectious Diseases and Microbiology 11,5 260.000 2321716 MITO 7 A Multicenter phase 3 Randomized Study with weekly paclitaxel in patients with Ovarian Cancer treated with first line chemotherapy PASCALE Oncology 2 11,5 293.550 2316263 An epigenetic approach to treatment of triple negative breast cancer Friuli Venezia Giulia Oncology 1 Basic 11,5 120.000 2316608 Management of couples with asymptomatic urogenital infections and ART failure Toscana Infectious Diseases and Microbiology 11,5 200.000 2307775 Novel predictive biomarkers for bevacizumab in colorectal cancer I. O. V. Oncology 2 11,5 300.000 2312572 Reproductive toxicity of Engineered Nanomaterials: mechanisms, effects, biomonitoring and tools for prevention Lazio Bioengineering Sciences and Technologies 11,5 330.000 2316816 Functional topography of the spinal motor output after spinal cord injury SANTA LUCIA Integrative, Functional, and Cognitive 11,5 420.640 2318270 GABAA receptor and chloride transporter physiopathological role in ALS SANTA LUCIA Molecular, Cellular, and Developmental 11,5 430.000 Pagina 55 di 142

2316204 EFFECTS OF NUTRACEUTICAL SPIRULINA AND DOCOSAHEXAENOIC ACID ENRICHED DIET DURING PREGNANCY AND LACTATION ON NEURODEVELOPMENT AND SUSCEPTIBILITY TO INFLAMMATION OF THE PROGENY Istituto Superiore di Sanita' Molecular, Cellular, and Developmental 11,5 192.000 2315068 Identification of EphA3 as a new molecular target in multiple myeloma: opportunity for a novel therapeutic approach with a specific monoclonal antibody CROB Oncology 1 Basic 11,5 420.000 2317044 LOW INVASIVE MARKERS DEVELOPMENT IN COLLAGEN 6 MYOPATHIES AND DUCHENNE MUSCULAR DYSTROPHY FOR DISEASE STAGING AND RESPONSE TO TREATMENT RIZZOLI Musculoskeletal, Oral and Skin Sciences 11,5 165.000 2320881 Proteomics and metabonomics strategies to characterize functional biomarkers of Polycyclic aromatic hydrocarbons contamination on dairy products Abruzzo Veterinary 11,5 230.000 2320703 Telemedicine for monitoring of asthmatic patients Evaluation of the outcome of treatment accordin to the style of life. OSPEDALE BAMBINO GESU' Risk, Prevention and Health Behavior 11,5 590.000 2318256 Posttraumatic stress disorder in parents of children with surgically correctable anomalies requiring surgery at birth OSPEDALE BAMBINO GESU' Biobehavioral and Behavioral Processes 11,5 200.000 2317660 Sharing of medical resources for the diagnosis and treatment of status epilepticus by a computer assisted telemedicine system Emerging Technologies and Training in s 11,5 600.000 2320736 In vivo manipulation of gamma delta T cells with zoledronate and low dose IL 2 for immunotherapy of malignant melanoma Sicilia Oncology 2 11,5 193.750 2317653 value of decompressive craniectomy associated to haematoma evacuation in the first 72 hours after traumatic events: a multicenter randomized controlled trial Emilia Romagna Surgical Sciences, Biomedical Imaging, and Bioengineering 11,5 208.888 Pagina 56 di 142

2318281 A novel in vivo system for functional reconstitution of bone and a functional bone marrow microenvironment/hematopoietic stem cell niche: a lead into scaffold free, cell only bone regeneration strategies, and into direct modeling of leukemic and cancer st Lazio Vascular and Hematology 11,5 375.000 2312521 Biomolecular and Biosensor innovative approaches to guarantee Protected Designation of Origin (PDO) Water Buffalo Mozzarella Cheese Istituto Zooprofilattico Sperimentale del Mezzogiorno Veterinary 11,5 600.000 2316914 Pyrimethamine derivatives: a new generation of antifolate drugs for treatment of metastatic melanoma. A preclinical study. Istituto Superiore di Sanita' Oncology 2 11,5 540.000 2319821 DELIVERY OF THERAPEUTICAL AGENTS INTO MELANOMA BY TGF β SWITCH DEPENDENT HOMING OF MESENCHYMAL STEM CELLS (MSC), ENDOTHELIAL PROGENITOR CELLS (EPC) AND ANTIGEN PRESENTING CELLS (APC) Toscana Oncology 1 Basic 11,5 550.000 2317265 Fertility preservation in women affected by endometriosis through oocyte vitrification Toscana Endocrinology, Metabolism, Nutrition and Reproductive Sciences 11,5 150.000 2305841 The MINA PROJECT. Mirror Neurons In Alcoholics: can Mirror Neuron System help us to understand and treat Alcohol Addiction? Emilia Romagna Brain Disorders and 11,5 378.000 2303169 Molecular determinants of immune evasion in childhood acute leukemia. OSPEDALE BAMBINO GESU' Immunology 11,5 582.200 2311297 Combined therapeutic cancer vaccine strategy for HCVrelated HCC PASCALE Oncology 2 11,5 583.700 2302035 Quantitative Advanced Imaging (PET/MRI) in the Surgery and Radiotherapy of High Grade Brain Tumours ARCISPEDALE Oncology 2 11,5 600.000 2300285 IDENTIFICATION OF GENES REGULATING SKIN FIBROSIS IN SCLERODERMA ISTITUTO DERMOPATICO DELL'IMMACOLATA Musculoskeletal, Oral and Skin Sciences 11,5 365.000 Pagina 57 di 142

2316786 2318208 Vitamin D as a disease modulator in multiple sclerosis: immunomodulatory activity on antigen presenting cells and gamma/delta T lymphocytes and regulation of their cross talk. TAT AND ENV BIND TO FORM A NOVEL HIV ENTRY COMPLEX THAT TARGETS CELLS AT THE PORTAL OF ENTRY AND HIV RESERVOIRS: IMPLICATIONS FOR THE DEVELOPMENT OF PREVENTATIVE AND THERAPEUTIC INTERVENTIONS AGAINST HIV/AIDS Istituto Superiore di Sanita' Immunology 11,5 300.000 Istituto Superiore di Sanita' AIDS and Related Research 11,5 599.500 2304124 Caveolin 1, PTRF expression and function in Non Small Cell Lung Cancer. IRCCS AOU San Martino IST (Genova) Oncology 1 Basic 11,5 215.000 2314182 Rethinking neuroinflammation in sporadic AD: exploring novel therapeutic and prognostic tools Istituto Superiore di Sanita' Brain Disorders and 11,5 560.000 2302679 Targeting epithelial to mesenchymal transition and chemoresistance mediated by endothelin 1 signaling in epithelial ovarian cancer REGINA ELENA Oncology 1 Basic 11,5 326.700 2316205 BPIFB4 longevity associated variants: evaluation by in vitro and in vivo studies for their potential modulation of diseases of aging MULTIMEDICA Biology of Development and Aging 11,5 286.400 2306233 Role of Dbl in epithelial cell transformation: identification of new therapeutic targets for carcinomas Liguria Oncology 1 Basic 11,5 400.000 2317809 Evaluation of the role of Copy Number Variations in the pathogenesis of inherited neurological and neuromuscular disorders through the development and validation of a rapid and efficient laboratory assay IRCCS AOU San Martino IST (Genova) Genes, Genomes and Genetics 11,5 325.000 2302996 Epigenetic therapy of leukemic stem cells in acute myeloid leukemias. I.E.O. Oncology 1 Basic 11,5 254.000 2311686 Beta adrenergic receptor blockade as a new, effective and safe therapy in the treatment of retinopathy of prematurity Toscana Cell Biology 11,5 405.000 Pagina 58 di 142

2315319 Rehabilitation of somatic deficits after stroke through training and non invasive brain stimulation AUXOLOGICO Integrative, Functional, and Cognitive 11,5 350.000 2317061 WHOLE EXOME SEQUENCING OF ADENOMATOUS POLYPOSIS PATIENTS FOR A GENETIC DIAGNOSIS AND NICAL APPLICATIONS C.R.O. AVIANO Oncology 1 Basic 11,75 560.000 2312695 DEVELOPMENT OF A NETWORK BASED MODEL FOR A COMPREHENSIVE NICAL DIAGNOSTIC MANAGEMENT OF HEREDITARY CANCER PATIENTS AND THEIR FAMILY MEMBERS I. O. V. Healthcare Delivery and 11,75 440.000 2305781 Caffeine as a potential therapeutic option for Alzheimer's disease. Istituto Superiore di Sanita' Brain Disorders and 11,75 548.000 2308387 Role of brain/cognitive reserves on neurodegenerative pathology SANTA LUCIA Biobehavioral and Behavioral Processes 11,75 350.000 2316913 Tailoring micro nanocarriers structural and surface properties to finely modulate the activation or regulation of immune responses: the allergy immunotherapy proof of concept Istituto Superiore di Sanita' Immunology 11,75 528.000 2319286 Nutritional factors in Rett syndrome and autism spectrum disorders: preclinical evaluation of dietary choline during early developmental phases Istituto Superiore di Sanita' Brain Disorders and 12 159.556 2309104 Development of a wearable system for the integrated assessment of seismocardiogram and other vital signs out of the laboratory setting. DON GNOCCHI Bioengineering Sciences and Technologies 12 341.000 2317376 Diagnosis and pathogenesis of Opisthorchis felineus, an emerging foodborne parasite in Italy Istituto Superiore di Sanita' Infectious Diseases and Microbiology 12 304.700 2315025 Hypoxia, inflammation and stem cells in cancer progression SAN RAFFAELE PISANA Oncology 1 Basic 12 410.000 2320323 Roles of ADP ribosylation in the regulation of the actin cytoskeleton and intracellular Ca2+ signaling Abruzzo Cell Biology 12 600.000 Pagina 59 di 142

2318520 NF kb signaling pathway,innate immunity and neurodegeneration in Alzheimer's disease NEUROLESI Brain Disorders and 12 280.000 2316215 Development of a novel test for detection of Bacillus anthracis DNA in urine Istituto Zooprofilattico Sperimentale della Puglia e della Basilicata Infectious Diseases and Microbiology 12 350.000 2306066 NEW DRUGS FOR BONE MASS RECOVER IN OSTEOPOROTIC PATIENTS AFFECTED BY RHEUMATOID ARTHRITIS (RA): NICAL/MEDICAL STUDY. Emilia Romagna Musculoskeletal, Oral and Skin Sciences 12 300.000 2301932 Identification of gender related differences in oxidative stress biomarkers associated with atherosclerotic disease progression Istituto Superiore di Sanita' Cardiovascular and 12 534.600 2315665 COPD global proteomics: a systems biology approach. SAN RAFFAELE PISANA Cardiovascular and 12 599.999 2317230 Normal and pathological development of locomotion in the first year of life SANTA LUCIA Brain Disorders and 12 486.640 2315486 Sentinel animals to monitor pollution around the former Balangero asbestos mine Piemonte Population Sciences and Epidemiology 12 285.000 2315044 SAFE FISH: safety and nutritional value assessment of Italian marine farmed fish Istituto Zooprofilattico Sperimentale della Sicilia Healthcare Delivery and 12 150.000 2318042 A new approach to cancer early diagnosis based on the identification of breast cancer related metabolites in human breath ISTITUTO TUMORI MILANO Oncology 2 12 335.500 2312255 Italian study on gene environment interactions in lymphoma aetiology: translational aspects Toscana Oncology 1 Basic 12 428.000 2314508 PanCareSurFupPanCare Childhood and Adolescent Cancer Survivor Care and Follow up Studies, Italian branch Piemonte Oncology 2 12 322.000 Pagina 60 di 142

2321108 Characterization of the role of HIV1 Tat in establishment and maintenance of viral reservoirs: implications for new strategies toward HIV eradication Emilia Romagna AIDS and Related Research 12 300.000 2322031 Interference evaluation of cancer microenvironment in the tumor specific immune response of pancreatic cancer patients Toscana Oncology 1 Basic 12 215.500 2319732 Non invasive prenatal diagnosis of genetic diseases by separation and enrichment of circulating fetal cells in maternal blood Abruzzo Genes, Genomes and Genetics 12 232.930 2304944 Gene expression profile at the onset of severe cardiac failure:identification and validation of new biomarkers Liguria Cardiovascular and 12 290.000 2314343 mir34a: clarifying its value in prognosis and therapy of Ewing s sarcoma. RIZZOLI Oncology 1 Basic 12 251.900 2320148 Novel immunotherapeutic strategies for the cure of human prostate cancer Immunology 12 550.000 2306761 G15 expression in pancreatic cancer:its prognostic and diagnostic value as a clinical/molecular marker and as a pharmacological target Veneto Oncology 1 Basic 12 397.000 2316101 Dissecting the molecular regulatory networks in human myeloid derived suppressor cells. I. O. V. Immunology 12 320.000 2316676 Mechanisms of interplay between Mycobacterium avium subspecies paratuberculosis and intestinal cells in Crohn s disease Istituto Zooprofilattico Sperimentale delle Venezie Digestive, Kidney and Urological Systems 12 427.900 2315930 Identification of downstream targets of BAG3/BRAFmediated regulation as potential candidate markers and therapy targets in Anaplastic Thyroid Carcinoma PASCALE Oncology 2 12 416.100 2308043 Role of mir in the cytokine mediated regulation of gene expression in neoplastic B cells IRCCS AOU San Martino IST (Genova) Oncology 1 Basic 12 420.000 Pagina 61 di 142

2311778 Effective functional measurements in musculoskeletal rehabilitation: guidelines, methodologies and tools for accreditation, assessment and appropriate performance of Movement Analysis Laboratories Istituto Superiore di Sanita' Musculoskeletal, Oral and Skin Sciences 12 600.000 2310980 Tregs/Th17 Imbalance, Intrahepatic Cytokine Milieu and Immune Dysregulation in Autoimmune Hepatitis Emilia Romagna Immunology 12 180.000 2319149 Protein profile of red blood cell and exosomes signature for early diagnosis of ovarian cancer Veneto Oncology 2 12 560.000 2320776 Development of an antimicrobial food packaging by using essential oils and nanotechnology EssencePack Istituto Zooprofilattico Sperimentale del Mezzogiorno Veterinary 12 600.000 2311235 EPIGENETIC DETERMINANTS OF DRUG SENSITIVITY AND NICAL OUTCOME IN OVARIAN CANCER HUMANITAS Oncology 2 12 425.000 2315966 Characterization of interactions among tumor, stromal and immune cells for the identification of potential targets in melanoma therapy. IRCCS AOU San Martino IST (Genova) Immunology 12 550.000 2314863 2305312 Identification of immunological and biochemical biomarkers of diagnostic, prognostic and therapeutic value in the management of Kawasaki disease Isolation and characterization of interferon gammaproducing myeloid cells from the bone marrow of Severe Aplastic Anemia patients (SAA) Istituto Superiore di Sanita' Immunology 12 400.000 GASLINI Vascular and Hematology 12 232.200 2316512 Next Generation Targeted resequencing Panels as a tool for multi gene testing in the diagnosis of Parkinson Disorder SAN RAFFAELE PISANA Genes, Genomes and Genetics 12 600.000 2316270 The role of oxidative damage to DNA and its repair in human gastrointestinal cancer Istituto Superiore di Sanita' Oncology 1 Basic 12 550.000 2315480 Role of mechanotransduction signals and sirtuins in rehabilitation coupled with physical activity SAN RAFFAELE PISANA Musculoskeletal, Oral and Skin Sciences 12 450.000 Pagina 62 di 142

2320164 Development of novel gene therapy approaches to cure the primary ciliary dyskinesia Toscana Cardiovascular and 12 370.000 2311793 Development of an in vitro assay for the diagnosis of latent tuberculosis infection (LTBI) based on a novel human immunodominant T cell epitope of the antigen PPE44 of Mycobacterium tuberculosis Toscana Infectious Diseases and Microbiology 12 214.500 2313970 Exploring the interactome of the high risk Human Papillomavirus oncoproteins to understand and dismantle its oncogenic power REGINA ELENA Oncology 1 Basic 12 448.800 2307633 Circulating micrornas as novel biomarkers for Amyotrophic Lateral Sclerosis Toscana Brain Disorders and 12 318.000 2309250 IDENTIFICATION OF MARKERS AND DEVELOPMENT OF SENSORS FOR EARLY PANCREATIC CANCER DIAGNOSIS Piemonte Bioengineering Sciences and Technologies 12 300.500 2306183 A marker of homeostatic failure locates seizure onset zone in surgically remediable focal epilepsies CARLO BESTA Brain Disorders and 12 527.000 2307685 Autoreactive T cell expansion profiles and mechanisms in patients with type I diabetes during beta cell replacement therapy Immunology 12 480.000 2311190 HIV drug resistance in resource limited settings : an assessment in naïve pregnant women in Malawi and the evaluation of the impact of a triple antiretroviral combination strategy for PMTCT Istituto Superiore di Sanita' AIDS and Related Research 12 400.000 2314204 Molecular events involved in progression from hepatitis C virus (HCV) chronic infection to hepatocellular carcinoma and in liver regeneration: mirnome and proteome analysis in experimental and clinical settings Istituto Superiore di Sanita' Oncology 2 12 580.000 2319883 Discovery of small molecules capable of eliminating the HIV T cellular reservoir Istituto Superiore di Sanita' AIDS and Related Research 12 590.000 2311427 Telomere Length, Risk of Ischemic Stroke and Prediction of Poststroke Recurrent Events NEUROLESI Brain Disorders and 12 408.000 Pagina 63 di 142

2312067 Extreme Obesity and Sleep Apnoea Syndrome: Redox Balance, Inflammation and Vitamin Profile. Effect of metabolic rehabilitation and non invasive mechanical ventilation. AUXOLOGICO Endocrinology, Metabolism, Nutrition and Reproductive Sciences 12 575.000 2304365 Prospective study in premanifest Huntington disease mutation carriers: new clinical and neuroradiological assessment tools for long term follow up and early signs evaluation CARLO BESTA Brain Disorders and 12 462.000 2314419 Therapeutic correction of mis spliced RNA transcripts and of protein conformational defects in Lysosomal Storage Disorders Toscana Genes, Genomes and Genetics 12 180.000 2305042 REGENERATION OF SCAPHOID BONE DEFICIENCY BY USING AUTOLOGOUS EX VIVO EXPANDED, GMP GRADE, BONE MARROW MESENCHYMAL STEM CELLS Veneto Surgical Sciences, Biomedical Imaging, and Bioengineering 12 465.000 2311515 A comprehensive immunological strategy for the prevention of relapse in elderly patients with acute myeloid leukemia according to genotype: adoptive immunotherapy with NK cells and anti WT1 vaccination Emilia Romagna Oncology 2 12 300.000 2309773 Health (cancer and atherosclerotic) risks from radiological medical imaging in grown up congenital heart disease patients Toscana Cardiovascular and 12 460.000 2311841 Telecare and Home Care: assessing cost effectiveness of a new approach to increase safety in home care avoiding the need to hospitalize for elderly, polypathologic, chronically ill, unstable subjects with movement handicaps Toscana Healthcare Delivery and 12 200.000 2318485 Sacral neuromodulation as treatment of urge incontinence in frail elderly female patients: a study of feasibility, safety and cost effectiveness analysis. Lazio Digestive, Kidney and Urological Systems 12 565.000 2313840 Investigating Huntington disease stage related biomarkers in the nervous and cardiovascular systems NEUROMED Brain Disorders and 12 600.000 Pagina 64 di 142

2314961 Individual risk for lung cancer and low dose CT Scan screening for occupationally ex exposed to asbestos. Toscana Oncology 2 12 600.000 2320263 Fluidodynamics of Fontan operation: A data base aiming at improvement of surgical outcome of the univentricular heart OSPEDALE BAMBINO GESU' Cardiovascular and 12 350.000 2312718 Surveillance, control and prevention of infections by multidrug resistant organisms in alternative healthcare settings: nursing and residential homes Sicilia Infectious Diseases and Microbiology 12 345.000 2312771 A prospective study on Oxaliplatin neurotoxicity: from basic science to rehabilitation looking for early preclinical signs of neuropathy. S.CAMILLO Oncology 2 12 316.000 2307452 A phase III study (IRMA3): breast cancer at low risk of local recurrence: irradiation and accelerated partial threedimensional conformal radiotherapy (3D CRT) versus standard radiotherapy and intraoperative radiotherapy(iort) versus standard radiotherapy Emilia Romagna Oncology 2 12 300.000 2318300 Motor underpinnings to screen autism (MUSA). Prospective study on movement perception and performance in younger siblings of children with Autism Spectrum Disorders. Searching for clinical predictors and neural correlates of early autism. STELLA MARIS Brain Disorders and 12 270.000 2318828 Prostate cancer and visceral obesity: an epidemiological, hormonal, metabolic and molecular study Veneto Digestive, Kidney and Urological Systems 12 448.479 2317567 The reactivity to 35% CO2 challenge as predictor of pharmacological treatment outcome and relapse in Panic Disorder. Lombardia Biobehavioral and Behavioral Processes 12 206.200 2319244 Collaborative model for the psychosocial care of the adult cancer patients and their caregivers: cluster, randomized trial to test a new way of care coordination. (HuCare 2: Humanization of cancer care, project 2) Lombardia Healthcare Delivery and 12 494.444 Pagina 65 di 142

2321757 Endothelial Dysfunction and Insulin Resistance: an experimental and translational study on the molecular mechanisms linking endothelial dysfunction, insulin signaling and cardiovascular damage Toscana Cardiovascular and 12 533.000 2310701 Cerebellar transcranial magnetic stimulation as a treatment option for levodopa induced dyskinesias and tremor NEUROMED Brain Disorders and 12,25 300.000 2314371 Readthrough of Premature Termination Codons to treat Kabuki syndrome CASA SOLLIEVO SOFFERENZA Genes, Genomes and Genetics 12,25 395.000 2310258 Exploring Ng MIP Neisseria gonorrhoeae Macrophage Infectivity Potentiator) and Ng OMPA (Neisseria gonorrhoeae Outer Membrane Protein A) as novel candidates to fight gonococcal infection due to resistant or multi drug resistant gonococci Istituto Superiore di Sanita' Infectious Diseases and Microbiology 12,25 400.000 2320251 ALTERED HOST MICROBE INTERACTION IN HIV: A POTENTIAL TARGET FOR INTERVENTION WITH PROTICS Lombardia AIDS and Related Research 12,25 373.000 2309128 Malignancy and invasiveness molecular determinants in oro pharyngeal squamous cell carcinomas. REGINA ELENA Oncology 1 Basic 12,33 441.000 2307803 CREATION OF A NATIONAL NETWORK FOR THE DIAGNOSIS OF MALIGNANT LYMPHOMAS Emilia Romagna Oncology 2 12,5 600.000 2308854 Development and assesment of a regional palliative care network. The Ligurian Palliative Care Demonstration Project. IRCCS AOU San Martino IST (Genova) Healthcare Delivery and 12,5 600.000 2310065 EBV reactivation and CD8+ T cell responses in Multiple Sclerosis SANTA LUCIA Immunology 12,5 470.000 2318212 Home based palliative care for people with severe multiple sclerosis: Developmental and pilot phases of the Palliative Network for Severely Affected Adults with MS in Italy (PeNSAMI) study CARLO BESTA Brain Disorders and 12,5 484.660 Pagina 66 di 142

2310959 Development of a novel lubricating gel containing antimicrobial loaded nanoparticles to prevent urinary catheter associated infections particularly in patients with neurogenic bladder requiring long term catheterization. SANTA LUCIA Infectious Diseases and Microbiology 12,5 350.000 2306948 NICAL AND PHARMACOLOGICAL EVALUATION OF TRABECTEDIN (T) IN BRCA MUTATION CARRIER AND BRCANESS PHENOTYPE OVARIAN CANCER PATIENTS ISTITUTO TUMORI MILANO Oncology 2 12,5 350.000 2321047 FRACTURE UNIT MULTIREGIONAL EXPERIMENTATION PROJECT (FRAME Project) Toscana Healthcare Delivery and 12,5 600.000 2306394 Mechanisms of mood control by inflammatory cytokines in Multiple Sclerosis. SANTA LUCIA Brain Disorders and 12,5 500.000 2319773 Evaluation of the effectiveness of ADL based exercises Vs point to point reaching tasks in robot mediated therapy of the upper limb for sub acute stroke patients SAN RAFFAELE PISANA Emerging Technologies and Training in s 12,5 600.000 2309714 ENDOGENOUS OUABAIN IS IMPLICATED IN ACUTE KIDNEY INJURY IN CARDIAC SURGERY AND CRITICALLY ILL PATIENTS: A METABOLOMIC STUDY Digestive, Kidney and Urological Systems 12,5 575.000 2304752 Estrogen and Gender Biased Autoimmunity in Systemic Lupus Erythematosus Istituto Superiore di Sanita' Immunology 12,5 600.000 2317211 Predictive value of FDG PET/CT Metabolic Tumour Volume in patients treated with neoadjuvant chemoradiation therapy for locally advanced rectal cancer Liguria Oncology 2 12,5 600.000 2308589 TOOLS FOR THE IMPROVEMENT OF ADHERENCE TO MEDITERRANEAN DIET AND PHYSICAL ACTIVITY IN PATIENTS WITH CARDIOVASCULAR DISEASES: AN INTERVENTION STUDY DON GNOCCHI Risk, Prevention and Health Behavior 12,5 194.000 2320365 Identification of clinical and genetic factors for personalized opioid therapy of cancer pain ISTITUTO TUMORI MILANO Oncology 2 12,5 580.800 Pagina 67 di 142

2321031 Validation of a new algorithm for HPV status assessment in head and neck carcinoma ISTITUTO TUMORI MILANO Oncology 2 12,5 303.600 2317940 WAC Project (Web Based Asthma Control) evaluation of the utility of a web based electronic health diary to improve control of moderate severe asthma Toscana Cardiovascular and 12,5 350.000 2315101 Co Amplification of the ERBB2 and RARA genes in breast cancer: a potential target for retinoid based therapy MAUGERI Oncology 2 12,5 600.000 2317676 ROLE OF WT1 AND ITS ISOFORMS IN HEMATOPOIETIC MALIGNANCIES SDN Genes, Genomes and Genetics 12,5 350.000 2320321 Advanced diagnostics and innovative procedures for diagnosis and management of patients affected by Limb Girdle Muscle Dystrophies (LMGD). NEUROLESI Musculoskeletal, Oral and Skin Sciences 12,5 159.000 2318072 RELATIOSHIPS BETWEEN VASOACTIVE MEDIATORS AND HEMODYNAMIC ALTERATIONS IN PATIENTS WITH MULTIPLE SCLEROSIS. Toscana Brain Disorders and 12,5 175.000 2321866 Exposure to occupational carcinogens and pathogenetic mechanisms in sinonasal adenocarcinomas Piemonte Oncology 1 Basic 12,5 157.256 2304806 Multiple gene analysis in bronchoscopic specimens from patients with advanced non small cell lung cancer I.E.O. Oncology 2 12,5 550.000 2317624 Effects of high intensity robot assisted training in hand function recovery and ADL independence after stroke: a multicentre randomized controlled single blind trial SAN RAFFAELE PISANA Brain Disorders and 12,5 299.896 2313206 MOLECULAR EVENTS IN MELANOMA PROGRESSION: REGULATION OF AP 2 TARGET GENES AND INVOLVEMENT IN TUMOR GROWTH AND METASTASIS. Piemonte Oncology 2 12,5 240.000 2317081 Exploring the role of drusen in the retinas as possible markers for the Alzheimer s disease pathology: a multidisciplinary approach. Istituto Superiore di Sanita' Brain Disorders and 12,5 570.000 Pagina 68 di 142

2319157 2314831 Inflammation and cancer: relevance of chemokines in myeloid cells recruitment, activation and cross talk with NK cells in tumor biology Understanding the adaptive immune response defects of WHIM syndrome patients HUMANITAS Immunology 12,5 550.000 HUMANITAS Immunology 12,5 550.000 2319750 Biological aging in dilated cardiomyopathy and chronic obstructive pulmonary disease Veneto Cardiovascular and 12,5 348.000 2311328 A PROSPECTIVE STUDY TO EVALUATE THE INFLUENCE OF GENETIC VARIATIONS IN ATM, OCT and MATE GENES IN THE GLYCAEMIC RESPONSE TO METFORMIN IN DRUG NAÏVE TYPE 2 DIABETIC PATIENTS AUXOLOGICO Genes, Genomes and Genetics 12,5 353.000 2306558 Characterization of new molecular mechanisms responsible for drug resistance and novel biomarkers predictive of the individual response to therapy in human breast and ovarian cancers CROB Oncology 2 12,5 540.000 2308033 GADD45beta cell permeable inhibitor peptide against cerebral ischemia Lombardia Brain Disorders and 12,5 500.000 2308228 Effects of Neuropeptide Y on the central nervous system neurons of rat models of Alzheimer Disease SANTA LUCIA Brain Disorders and 12,5 350.000 2302480 MicroRNA replacement therapy for the treatment of Neuroblastoma Liguria Oncology 2 12,5 397.980 2315222 Nanotecnology based drug delivery : new generation nanovector for drug delivery in human bone diseases. GALEAZZI Musculoskeletal, Oral and Skin Sciences 12,5 190.000 2320903 ROLE OF PERFUSION COMPUTED TOMOGRAPHY(PCT)AND VASCULAR ENDOTHELIAL GROWTH FACTOR A(VEGF A)SERUM LEVELS IN THE MANAGEMENT OF HIGH GRADE GLIOMAS(HGG):NEW METHODS OF MONITORING TREATMENT? NEUROMED Oncology 1 Basic 12,5 150.000 Pagina 69 di 142

2315673 Molecular and Functional Characterization of a Polycystin/Nephrocystin Complex Digestive, Kidney and Urological Systems 12,5 600.000 2316309 Definition of the prognostic and biological roles of tissueassociated and soluble biomarkers in epithelial ovary cancer exploiting well characterized retrospective and prospective clinical series of samples ISTITUTO TUMORI MILANO Oncology 2 12,5 425.800 2321379 Physiological effects of extracellular guanosine triphosphate (GTP) on renal cells and water transport Abruzzo Cell Biology 12,5 150.000 2315238 Analysis of the host pharmacogenetic background for prediction of outcome and toxicity in mantle cell lymphoma (MCL) treated with R HDS Lombardia Interdisciplinary Molecular Sciences and Training 12,5 200.000 2320678 A proteomic and lipidomic approach to discover diagnostic and predictive markers of lung cancer. Emilia Romagna Oncology 2 12,5 600.000 2315099 Predictive biomarkers of melanoma progression and clinical response to chemo immunotherapeutic therapies using new medical imaging approaches SAN GALLICANO Oncology 2 12,5 600.000 2306200 Relevance of host factors in the pathogenesis of HCVrelated lymphoproliferative disorders Toscana Oncology 1 Basic 12,5 350.000 2299929 Whole transcriptome changes induced by vaccineelicited immune responses in melanoma patients: providing the rationale for the development of dynamic antigen updating of dendritic cell vaccines Emilia Romagna Immunology 12,5 525.000 2317767 Immunogenic cell death as predictive and real time marker of response to EGFR targeted therapy in CRC patients I.E.O. Oncology 2 12,5 560.000 2311097 Mast cells translate external challenges into immune regulation affecting colitis and colorectal cancer. ISTITUTO TUMORI MILANO Immunology 12,5 539.500 2319127 Nociceptin/Orphanin FQ as a biomarker for Parkinson s disease Friuli Venezia Giulia Brain Disorders and 12,5 450.000 Pagina 70 di 142

2316132 Functional studies of deregulated micrornas in Sezary Syndrome ISTITUTO DERMOPATICO DELL'IMMACOLATA Oncology 1 Basic 12,5 312.000 2319875 Efficacy of nicotine dependence pharmacotherapy based on individual pharmacokinetic profile and identification of pharmacogenetic determinants of drug response Toscana Brain Disorders and 12,5 190.000 2321864 NICAL IMPACT OF TISSUE AND CIRCULATING MOLECULAR MARKERS IN THE DIAGNOSIS AND FOLLOW UP OF THYROID CANCER Toscana Oncology 2 12,5 150.000 2317171 ACUTE INFLAMMATORY LEUKOENCEPHALOPATHIES: A MULTIDISCIPLINARY STUDY ON AETIOPATHOGENETIC MECHANISMS AND IDENTIFICATION OF DISEASE MARKERS MONDINO Brain Disorders and 12,5 600.000 2317800 Role of stromal cells in lymphoma mediated immunosuppression: a novel target for the treatment. IRCCS AOU San Martino IST (Genova) Oncology 1 Basic 12,63 300.000 2311457 Parkinson's Disease: a new approach to motor and cognitive neurorehabilitation FATEBENEFRATELLI Brain Disorders and 12,63 595.000 2307785 Integrated risk assessment for food safety emerging risks in sustainable farming systems (IRASF) Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche Veterinary 12,67 600.000 2319225 STem cells Mobilization in Acute Myocardial Infarction Outcome Trial (STEM AMI OUTCOME Trial): efficacy and functional substudies Lombardia Cardiovascular and 12,83 400.000 2316293 Colorectal cancer: Vitamin D, VDR and beta Catenin expression study: from biological pathways to clinical prevention. I.E.O. Oncology 2 13 389.000 2318533 Evaluation of chemotherapy induced cardiotoxicity utilizing cardiac byomarkers doppler echocardiography and Magnetic Resonance Imaging Lazio Brain Disorders and 13 280.000 Pagina 71 di 142

2310610 CONFOCAL MICROSCOPY TO ENHANCE THE TREATMENT OF EPITHELIAL SKIN CANCERS MAUGERI Surgical Sciences, Biomedical Imaging, and Bioengineering 13 266.156 2312770 CHRONIC KIDNEY DISEASE (CKD) AND CARDIOVASCULAR RISK. MOLECULAR MECHANISMS, NICAL IMPLICATIONS AND NEW PREVENTIVE STRATEGIES Lombardia Digestive, Kidney and Urological Systems 13 450.000 2320768 LOGICAL BANK TO IDENTIFY MARKERS OF DISEASE ACTIVITY RELATED TO NICAL VARIABLES AND MODIFYING DRUGS IN MULTIPLE SCLEROSIS Emilia Romagna Brain Disorders and 13 500.000 2318453 A randomized multicenter study to compare the efficacy of additional tumor debulking surgery versus chemotherapy (CT) alone for recurrent platinum(p) sensitive ovarian cancer (OC) PASCALE Oncology 2 13 308.000 2314429 NICAL IMPACT OF CIRCULATING TUMOR CELLS AND MOLECULAR MARKERS IN THE DIAGNOSIS AND FOLLOW UP OF SOLID TUMORS Toscana Oncology 2 13 500.000 2321301 Semicarbazide sensitive amine oxidases (SSAOs) and matrix degrading metalloproteases (MMPs): a multidisciplinary study of their possible contribution to cerebral amyloid angiopathy (CAA) in Alzheimer's disease. SAN RAFFAELE PISANA Brain Disorders and 13 500.000 2318462 Sgk1: a novel regulator of genomic stability in human cancer Calabria Oncology 1 Basic 13 200.000 2319617 Combined use of transcranial direct current stimulation and speech therapy to treat patients with aphasic stroke: short and long term effects on anomia MAUGERI Emerging Technologies and Training in s 13 420.000 2321841 BDNF polymorphism, calprotectin and clinical phenotype in Rett syndrome Toscana Brain Disorders and 13 150.000 Pagina 72 di 142

2317438 Functional and effective connectivity evaluation in drugresistant epileptic patients candidates to surgery.a new tool for identification of the seizure onset zone and prediction of memory and cognitive outcome. Toscana Brain Disorders and 13 320.000 2315306 "Distribution of allelic polymorphism (TAAA)n in the Sex Hormone Binding Globulin (SHBG) gene in breast cancer patients with or without hormone therapy:relations with SHBG plasma levels and nutrictional factors". ONCOLOGICO DI BARI Genes, Genomes and Genetics 13 315.000 2311513 Experimental models for investigation of interrelationship between CSCs/TICs and metastasis Emilia Romagna Oncology 1 Basic 13 510.000 2313069 Cytoreduction and Hipec in the treatment of OvaRIaN cancer CHORINE StudyStage IIIC unresectable epithelial ovarian/tubal cancer with partial or complete response after 1st line neoadjuvant chemotherapy (3 Lombardia Oncology 2 13 450.000 cycles CBDCA+Paclitaxel): a phase 3 pros 2317530 The use of Nanoparticles in food technology: release assessment and development of analytical methods through selected case studies Istituto Zooprofilattico Sperimentale delle Venezie Bioengineering Sciences and Technologies 13 546.700 2315722 Effects of conventional rehabilitation terapy and combined restorative interventions in patients with post stroke deficits of the upper limb S.CAMILLO Brain Disorders and 13 270.000 2319666 Potential relevance of HLA G, gelatinases and herpes viruses as markers of tumor invasion and progression and their association with CT and MRI perfusion findings in patients with high grade glioma Emilia Romagna Brain Disorders and 13 400.000 2315152 Internet addiction disorder in adolescents: identification of possible biological and personality markers Toscana Brain Disorders and 13 194.000 Pagina 73 di 142

2318690 DEVELOPMENT IN ACUTE MYELOID LEUKEMIA PATIENTS OF A GENOMIC TEST BASED ON PROFILING OF APOPTOTIC MACHINERY AND OF mi RNA FOR REFINEMENT OF PROGNOSTIC RISK CLASSIFICATION AND TO GUIDE POST REMISSIONAL THERAPEUTIC STRATEGY Sicilia Oncology 2 13 326.000 2316438 Development and evaluation of a reverse transcriptase Real Time PCR assay for the study of the presence of viable Toxoplasma gondii in vegetable and meat Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta Veterinary 13 450.000 2319190 Understanding the function of WRNIP1 in the maintenance of common fragile site stability and in lung cancer development Istituto Superiore di Sanita' Oncology 1 Basic 13 450.000 2315210 Therapeutic strategies in refractory chronic daily headache: A multicenter, open, randomized, controlled trial. Istituto Scienze Neurologiche Emerging Technologies and Training in s 13 364.000 2314734 User participation in payment of health treatments(copayement) Agenzia per i Servizi Sanitari Regionali Healthcare Delivery and 13 450.000 2315570 Nitrosation of drugs of abuse in human saliva at the acidic ph of the stomach: mechanism of transformation and evaluation of associated carcinogenic risk Istituto Superiore di Sanita' Oncology 1 Basic 13 300.000 2321755 CIRCULATING ANTI TRANSGLUTAMINASE ANTIBODIES: A NOVEL MARKER OF RECURRENT ABORTION AND A KEY INFLUENCER OF NEO ANGIOGENESIS Molise Cell Biology 13 600.000 2315562 Hydrogen sulphide (H2S) as a novel player in endothelial dysfunction associated to hypertension SAN RAFFAELE PISANA Cardiovascular and 13 400.000 2308519 COMBINATORIAL IMMUNOLOGICAL AND NANOPARTICLE MEDIATED TARGETING OF THE EARLY STEPS OF THE METASTATIC DISEASE C.R.O. AVIANO Oncology 1 Basic 13 547.000 2309920 Fatigue relief in Multiple Sclerosis by transcranial Direct Current neurostimulation (tdcs). [FaMuSne] SAN RAFFAELE PISANA Brain Disorders and 13 336.000 Pagina 74 di 142

2321819 Custom made devices for bone regenerative medicine. RIZZOLI Musculoskeletal, Oral and Skin Sciences 13 600.000 2320782 Emerging contaminants in the feed food chain: integrated models to support risk analysis Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta Veterinary 13 600.000 2310035 Characterization and validation of new prognostic markers in high grade ovarian cancer. C.R.O. AVIANO Oncology 1 Basic 13 227.800 2306109 In vivo modeling glioblastoma to identify new therapeutic targets and assay a novel oncolytic therapy IRCCS AOU San Martino IST (Genova) Oncology 1 Basic 13 480.000 2316373 Biomaterial functionalization to improve biofunctionality and osteointegration of medical devices for healthy and osteopenic bone. RIZZOLI Musculoskeletal, Oral and Skin Sciences 13 504.000 2302935 The response to intestinal microbiota in peripheral blood and gut mucosa from patients with Crohn's Disease: from the definition of immune profiles to the development of induced pluripotent stem cells for pharmacologic studies. BURLO GAROFALO Digestive, Kidney and Urological Systems 13 300.000 2314292 Role of host pathogen interplay in genital cancer pathogenesis: gene mutations and nucleotide polymorphisms as determinants of cancer susceptibility and response to therapy PASCALE Oncology 1 Basic 13 517.000 2309014 Identification and pathways to care of children with complex or chronic health conditions and special health care needs Emilia Romagna Healthcare Delivery and 13 360.000 2320124 Chemical protection against ionizing radiation in subjects undergoing radiodiagnostic procedures: analysis of the role of natural compounds in a translational research plan Istituto Superiore di Sanita' Risk, Prevention and Health Behavior 13 599.800 2319903 NICAL AND INSTRUMENTAL EVALUATION OF A LOCAL INTRAOPERATIVE DRUG THERAPY TO IMPROVE PRIMARY STABILITY IN TOTAL KNEE REPLACEMENT RIZZOLI Musculoskeletal, Oral and Skin Sciences 13 600.000 Pagina 75 di 142

2318542 IMmunity, Inflammation and Carotid ATherosclerosis: the IMICAT study MONZINO Vascular and Hematology 13 585.200 2312974 Development of innovative immunotherapeutic strategies against oligomeric beta amyloid isoforms by intracellular antibody technology SAN RAFFAELE PISANA Brain Disorders and 13 590.000 2314226 MOLECULAR AND FUNCTIONAL PROFILES OF NON SELF SUFFICIENCY ELDERLY:FROM DIAGNOSIS TO CARE MODELS Calabria Healthcare Delivery and 13 550.000 2308208 and biological studies on the increased thyroid cancer incidence in the volcanic area of Sicily. Sicilia Oncology 2 13 515.000 2304708 Non cancer (atherosclerotic, neurocognitive, reproductive) health effects of chronic low dose radiation exposure in cardiac catheterization lab workers (the Healthy Cath Lab Study) Sicilia Cardiovascular and 13 595.000 2321827 A randomized intervention study to assess the effect of the Mediterranean Diet on plasma fatty acid profile. MONZINO Cardiovascular and 13 174.900 2312635 Comparative effectiveness: Hospital volumes and outcomes of treatments. Systematic reviews and observational study in the Italian NHS Agenzia per i Servizi Sanitari Regionali Healthcare Delivery and 13 500.000 2318733 Predictive value of heart rate viariability in fetuses of high risk pregnancies. Development of a new method for accurate and rapid signal detection and analysis. Friuli Venezia Giulia Endocrinology, Metabolism, Nutrition and Reproductive Sciences 13 570.000 2314768 Safety and technology assessment of Ultra High Field Magnetic Resonance 7 Tesla System for children applications STELLA MARIS Surgical Sciences, Biomedical Imaging, and Bioengineering 13 305.000 2314162 Proteomics of benign and malignant parathyroid tumors: identification of molecular and humoral biomarkers for early diagnosis of sporadic and familial parathyroid cancer Toscana Oncology 1 Basic 13 400.000 Pagina 76 di 142

2317481 ROLE OF HOST AND VIRAL FACTORS ON THE EXPERIMENTAL INFECTIONS OF CYNOMOLGUS MACAQUES WITH SIMIAN OR SIMIAN HUMAN IMMUNODEFICIENCY VIRUS. Istituto Superiore di Sanita' AIDS and Related Research 13 274.400 2313266 FROM HUMAN TO CANINE. SERUM TUMOUR MARKERS EXPRESSION IN MAMMARY CANCER: NEW PERSPECTIVE IN VETERINARY ONCOLOGY? Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche Veterinary 13 287.000 2321411 Role of mir 155 in FLT3 ITD mutated acute myeloid leukemia: studies of network, signalling and silencing. Sicilia Oncology 1 Basic 13 180.000 2317111 Circulating Tumour Cells (CTC) and Cancer Stem Cells from human prostate: new device and tools for markers detection,cell isolation and their ex vivo expansion as three dimensional structures Lazio Digestive, Kidney and Urological Systems 13 600.000 2309396 Explaining coronary heart disease mortality trend in Italy between 2000 and 2010 and forecasting health and economic scenarios for prevention strategies Istituto Superiore di Sanita' Population Sciences and Epidemiology 13 542.300 2315847 A perspective study in HIV infected individuals to determine the impact of HAART and the role of specific antiviral immune responses on the establishment and maintenance of virus reservoirs, which are key for chronic virus persistence and disease progress SAN GALLICANO AIDS and Related Research 13 600.000 2315976 Splicing variants of L1CAM in human cancer cells: functional relevance in modulating NK cell mediated antitumor activity. HUMANITAS Immunology 13 452.000 2307698 Mechanisms and actions of Regorafenib, a new hepatoma (HCC) therapy DE BELLIS Oncology 2 13 349.000 2304955 Whole exome resequencing in familial Neural Tube Defects GASLINI Genes, Genomes and Genetics 13 362.000 2318589 Biological and biomechanical experimentation using a new vetro ceramic scaffold for bone regeneration in order to evaluate surgical and pharmacological treatments before testing on the patient. Piemonte Bioengineering Sciences and Technologies 13 300.000 Pagina 77 di 142

2318666 Multiplex Ligation Probe Amplification (MLPA) analysis, 5p 13.2 Loss Of Heterozygosity (LOH),CA SSR1 EGFR microsatellite analysis and NIPBL Illumina Solexa sequencing in Thymic Epithelial Tumors and Squamous Cell Lung Carcinomas metastatic to the medias REGINA ELENA Oncology 1 Basic 13 285.000 2314647 Identification of new prognostic factors for disease outcome in a regional cohort of patients with B cell chronic lymphocytic leukemia (B CLL) Veneto Vascular and Hematology 13 450.000 2308819 Analysis of macrophage and neutrophil subpopulations in the vascular remodelling occurring in HCC genesis and progression. Implications for early diagnosis, prognosis and therapy. HUMANITAS Oncology 2 13 508.000 2315661 Continuity of mental disorders from childhood to early adulthood in Emilia Romagna and Piemonte: comparison with the Danish population Emilia Romagna Risk, Prevention and Health Behavior 13 290.000 2319238 New candidate gene for hemiplegic migraine and episodic ataxia Lazio Genes, Genomes and Genetics 13 300.000 2318456 Papillomavirus (HPV) genital infection in men: genotypes prevalence, presence of viral transcripts and association with genital clinical signs and sperm function Sicilia Endocrinology, Metabolism, Nutrition and Reproductive Sciences 13,17 293.000 2320975 Characterization of melanoma cells from primary and metastatic human melanoma in culture: prognostic and therapeutic implications Emilia Romagna Oncology 1 Basic 13,25 300.000 2318109 Innovative tools to predict the response to chemotherapy in cancer patients Oncology 1 Basic 13,33 450.000 2318023 PLERIXAFOR ADMINISTRATION AND MOBILIZATION OF ENDOTHELIAL PROGENITOR CELLS TO PROMOTE NEO VASCULARIZATION IN PATIENTS WITH CRITICAL LIMB ISCHEMIA Cardiovascular and 13,34 600.000 2311163 Fertility preservation in young Oncological female patients REGINA ELENA Endocrinology, Metabolism, Nutrition and Reproductive Sciences 13,5 600.000 Pagina 78 di 142

2307834 Priority setting in healthcare: the case of home care program in Tuscany Region for heart failure patients Toscana Healthcare Delivery and 13,5 350.000 2306123 Biological markers in bone metastases from prostate cancer: evaluation of live and apoptotic Circulating (CTC) and Disseminated tumor cells (DTC) in patients undergoing chemotherapy and correlation with tumor response and bone turnover rate. I. O. V. Oncology 2 13,5 150.000 2312774 GENetics of familial and sporadic Lone Atrial Fibrillation (GenLAF) SAN MATTEO Genes, Genomes and Genetics 13,5 510.000 2305130 Patient participation in Change of Shift Procedures. The Implementation of the Bedside handover for the improvement of nursing quality ARCISPEDALE Healthcare Delivery and 13,5 154.927 2321299 Health Technology assessment on mesenchymal stem cells and growth factors in orthopedics and traumatology Agenzia per i Servizi Sanitari Regionali Healthcare Delivery and 13,5 450.000 2308180 Diurnal and Inter visit IOP fluctuations: a risk factor for conversion from ocular hypertension to primary openangle glaucoma? FATEBENEFRATELLI Risk, Prevention and Health Behavior 13,5 508.889 2302872 GENETIC AND NEUROLOGICAL INFLUENCES ON RISK TAKING PROPENSITY Istituto Superiore di Sanita' Population Sciences and Epidemiology 13,5 389.100 2309078 Vg9Vd2 T cells in combination with zoledronate as novel immunotherapeutic approach for human neuroblastoma GASLINI Oncology 2 13,5 367.200 2305826 Pathogenic mechanisms and animal models of hereditary neurodegenerative cerebellar diseases due to mitochondrial defects. Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta Genes, Genomes and Genetics 13,5 600.000 2311149 THE EFFECTIVENESS OF STRUCTURED PSYCHOEDUCATION FOR RELAPSE PREVENTION IN BIPOLAR DISORDERS FATEBENEFRATELLI Biobehavioral and Behavioral Processes 13,5 400.000 2318916 Comparative efficiency and risk assessment of grafting human gabaergic neural precursors from different sources in experimental models of Huntington disease. SAN MATTEO Brain Disorders and 13,5 370.000 Pagina 79 di 142

2321305 RESPIRATORY TRAINING IN HEART FAILURE: A NON INVASIVE METHOD TO INCREASE THE CHOLINERGIC ANTI INFLAMMATORY PATHWAY MAUGERI Cardiovascular and 13,5 206.000 2320987 2322068 Metabolomic analysis of primary immunodeficiency and its application to a low cost neonatal screening program. Assessment and longitudinal monitoring of thymic output and immune status in the 22q11.2 deletion syndrome Toscana Immunology 13,5 242.000 Toscana Immunology 13,5 130.000 2317999 The role of Integrin alpha5/beta1 as a potential I. O. V. Oncology 2 therapeutic target in bone metastasis: a translational study 13,5 450.000 2311704 A translational study to identify and validate predictive molecular and cytogenetic biomarkers of durable complete response to trastuzumab containing chemotherapy for HER2 positive metastatic or locally advanced breast cancer HUMANITAS Oncology 2 13,5 432.400 2316052 Adult Niemann Pick type C disease as a model of tauopathy. Implications for the pathogenesis of Alzheimer disease. CARLO BESTA Brain Disorders and 13,5 385.000 2316560 PTPRJ and EGFR as targets for innovative molecular therapies of lung cancer Calabria Oncology 2 13,5 600.000 2317801 Role of the mitogen activated protein kinase ERK5 in chronic liver injury and hepatocellular carcinoma Toscana Digestive, Kidney and Urological Systems 13,5 400.000 2321614 Analysis of the clinical heterogeneity on a wide cohort of Rett patient through a biochemical and molecular approach AUXOLOGICO Genes, Genomes and Genetics 13,5 455.000 2320120 Impact of screening on survival in breast cancer patients: the role of tumor biology Toscana Population Sciences and Epidemiology 13,5 155.400 2321934 Pharmacoepidemiology, pharmacosurveillance and identification of predictive factors of oxaliplatin neurotoxicity in colorectal cancer: development and validation of a prognostic score Toscana Oncology 2 13,5 548.900 Pagina 80 di 142

2315106 Study of a method of calculation of the optimum radionuclide activity in radioimmunotherapy of tumors based on the reduction of the target mass Veneto Oncology 2 13,5 501.000 2321988 Proteomic salivary analysis and a mathematical model for diagnosis and classification of rheumatoid arthritis and early rheumatoid arthritis. Toscana Musculoskeletal, Oral and Skin Sciences 13,5 230.000 2312696 Antiplatelet aspirin therapy and megakaryocytic gene expression: molecular and cellular mechanisms underlying "drug resistance" in preventing cardiovascular events. Istituto Superiore di Sanita' Vascular and Hematology 13,5 300.000 2313199 ROLE OF MATERNAL INTRAPARTUM ANTITIC PROPHYLAXIS ON NEONATAL GUT MICROTA FLORA AND ONSET OF LATER ALLERGY RELATED DISEASES. Lombardia Infectious Diseases and Microbiology 13,5 220.000 2311357 Pathogenesis of idiopathic thromboembolism: role of antiendothelial auto antibodies and endothelial cell dysfunctions. HUMANITAS Immunology 13,5 433.000 2321217 Identification and validation of co morbidity scores and analysis of their impact on the fitness for treatment in patients with solid and haematological tumours HUMANITAS Healthcare Delivery and 13,5 590.000 2314199 Multidisciplinary study of the motor function in obese subjects with Prader Willi syndrome: from molecular control to muscular performance. AUXOLOGICO Musculoskeletal, Oral and Skin Sciences 13,5 450.000 2319035 Metal ions levels in symptomatic and asymptomatic patients with metal on metal replacement Lombardia Risk, Prevention and Health Behavior 13,5 300.000 2320725 THE ROLE OF ALCOHOL USE IN PATIENTS WITH A FIRST EPILEPTIC SEIZURE IN DIFFERENT POPULATIONS. Piemonte Population Sciences and Epidemiology 13,5 250.000 2319147 Identification and characterization of new SHOX related and SHOX unrelated mutations by Next Generation Sequencing analysis and pharmacogenomics evaluation of rhgh treatment Emilia Romagna Genes, Genomes and Genetics 13,5 600.000 Pagina 81 di 142

2321961 Metabolic syndrome and liver cancer: surveillance program on large population in Veneto Veneto Risk, Prevention and Health Behavior 13,5 500.000 2317718 Evaluation of Neuroprotection with NGF Mimetic Compounds Using Molecular Microimaging of Apoptotic Post ischemic Neuronal Death Toscana Brain Disorders and 13,75 360.000 2319163 Dietary patterns in midlife and occurrence of Alzheimer disease in old ages Lombardia Population Sciences and Epidemiology 13,75 229.000 2321608 Long term Legionella control in hospital hot water distribution systems by water treatment with natural terpenoid based products: assessment of their antimicrobial and toxicological activities in batch, pilotplant and real scale conditions. Istituto Superiore di Sanita' Infectious Diseases and Microbiology 13,75 516.000 2319246 Mitochondrial dysfunction in ALS : a study of novel molecular partners as targets for therapeutic interventions Emilia Romagna Molecular, Cellular, and Developmental 13,84 600.000 2306418 Gender and age related differences in motility and permeability responses in human colon: role of estrogens. DE BELLIS Digestive, Kidney and Urological Systems 14 440.000 2315126 Modulation of mir 221 and mir 222 in skeletal muscle cells: impact on muscle physiology and pathology Istituto Superiore di Sanita' Musculoskeletal, Oral and Skin Sciences 14 412.200 2320364 Molecular modeling and functional analyses of EGFR for the selection of lung cancer patients eligible for targeted therapy with receptor kinase inhibitors ISTITUTO TUMORI MILANO Oncology 2 14 400.400 2314316 Antiprotons vs photons: a new hypothesis for radiotherapy ONCOLOGICO DI BARI Oncology 2 14 600.000 2322015 STUDIES OF NEOPLASTIC PREVALENCE IN SINATHROPUS ANIMALS LIVING ON NATIONAL INTEREST SITES(SIN)IN CAMPANIA REGION AND EPIDEMIOLOGICAL RESEARCH ON ENVIRONMENTAL ONCOLOGICAL RISKS Istituto Zooprofilattico Sperimentale del Mezzogiorno Veterinary 14 600.000 Pagina 82 di 142

2317410 Glia immune crosstalk in multiple sclerosis Molecular, Cellular, and Developmental 14 550.000 2321780 Ovarian serous carcinoma:identification of prognostic and predictive markers and risk assessment. Calabria Oncology 1 Basic 14 225.000 2321816 Integrated approach to investigate the effect of environmental pollution on reproductive outcomes Emilia Romagna Genes, Genomes and Genetics 14 525.000 2318024 Circulating microrna as potential biomarkers of prediabetic and diabetic complications Veneto Cardiovascular and 14 350.000 2304457 A therapeutic approach to Fragile X syndrome based on the pharmacology of Rho GTPases Istituto Superiore di Sanita' Brain Disorders and 14 283.768 2299760 Sensitizing cancer stem cells driven glioma to radiotherapy via pharmacological inhibition of Ataxia Telangiectasia Mutated protein IRCCS AOU San Martino IST (Genova) Oncology 2 14 152.000 2304699 Innate immune signaling networks in intestinal epithelial cells and their role in shaping T cell responses in inflammatory bowel diseases Istituto Superiore di Sanita' Immunology 14 350.000 2318152 Radiation effects of low and/or protracted doses: from the mechanisms underlying the biological effects to the impact on public health Istituto Superiore di Sanita' Oncology 2 14 599.500 2314432 CDKL5 variant of Rett s syndrome: clinical phenotype and effects of mutations on the development of the central nervous system in view of future therapeutic approaches Istituto Scienze Neurologiche Brain Disorders and 14 396.756 2310965 New treatments for alleviation of neuropathy and regenerative impairment in diabetes. MULTIMEDICA Cardiovascular and 14 585.942 2315037 Post Transplant Hematopoiesis: a model to understand the mechanisms of hematopoietic stem cells (HSC) aging and the interactions between HSC and microenvironment. IRCCS AOU San Martino IST (Genova) Vascular and Hematology 14 500.000 Pagina 83 di 142

2316983 Development of bispecific antibodies for therapeutic approaches against HIV infection. Istituto Superiore di Sanita' AIDS and Related Research 14 592.717 2314940 Studies of the pathogenic mechanisms and zoonotic role of Porcine Circovirus type 2 (PCV2) and Torque Teno virus (TTV) Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche Veterinary 14 414.000 2316288 Genetic and epigenetic mechanisms in addiction: An opportunity for development of new pharmacotherapeutic strategies for alcoholism. FATEBENEFRATELLI Brain Disorders and 14 570.500 2316587 How to improve and rationalize targeted head and neck squamous cell carcinoma treatments ISTITUTO TUMORI MILANO Oncology 2 14 500.005 2314595 The mevalonate (Mev) pathway as a common metabolic target to modulate the susceptibility of Multiple Myeloma (MM) and Chronic Lymphocytic Leukemia (CLL) tumor cells to chemotherapy, environmental prosurvival signals, and immune recognition by Vgamma9Vde Piemonte Oncology 2 14 483.000 2318437 Identification of novel targets in thyroid carcinogenesis by sirna based loss of function screening ISTITUTO TUMORI MILANO Oncology 1 Basic 14 270.050 2306441 Monitoring allogeneic Hematopoietic stem cells transplant patients for viral load and CMV drug resistance genotypes GASLINI Infectious Diseases and Microbiology 14 475.000 2306673 MicroRNA Signature of Vascular Complications in Type 1 Diabetes Piemonte Cardiovascular and 14 350.000 2316966 Development and progression of breast cancer: when EMT meets stemness C.R.O. AVIANO Oncology 1 Basic 14 417.000 2315663 Personalising curative treatment decision for locally advanced head and neck cancer through identification of biological markers ISTITUTO TUMORI MILANO Oncology 2 14 500.600 2308055 Analysis of the effect of chemotherapeutic treatment on trastuzumab cytotoxic activity ISTITUTO TUMORI MILANO Oncology 2 14 429.000 Pagina 84 di 142

2319250 Enhancing Transparency of Reporting of Systematic Reviews to Improve Health Care Emilia Romagna Healthcare Delivery and 14 399.000 2308314 CHARACTERIZATION OF NEW MOLECULAR MARKERS OF NEUROINFLAMMATION ASSOCIATED WITH ALZHEIMER'S DISEASE Sicilia Molecular, Cellular, and Developmental 14 213.000 2316283 Opportunistic virus infections in transplant recipients and patients with chronic inflammatory diseases treated with biological immunosuppressive drugs SAN MATTEO Immunology 14 570.000 2321877 Studies on the cardiovascular effects of mandibular stretching and on their potential application in the treatment of arterial hypertension Toscana Cardiovascular and 14 218.233 2315697 USE OF NEXT GENERATION SEQUENCING IN NICS: EVALUATION OF MODELS OF EARLY OR COMPREHENSIVE DIAGNOSIS IN A REGIONAL ASSET Liguria Genes, Genomes and Genetics 14 400.000 2312026 Screening for Autoimmune Polyglandular Syndrome Type 2 in patients with autoimmune thyroiditis: definition of methodology and cost benefit analysis. Toscana Endocrinology, Metabolism, Nutrition and Reproductive Sciences 14 195.000 2321533 Epidemiological, clinical and molecular aspects of Environmental Intolerance Disorders with difficult diagnosis: Implications for Disease Definition, Diagnosis, and Treatment. ISTITUTO DERMOPATICO DELL'IMMACOLATA Population Sciences and Epidemiology 14 300.000 2320234 Effectiveness of multidisciplinary clinical approach and psychological treatment on enhanced recovery after surgery in patients with Inflammatory Bowel Diseases (IBD) Toscana Risk, Prevention and Health Behavior 14 240.000 2314793 Response Evaluation Criteria in Solid Tumors: a comparative study between Imaging and Biomolecular indices Sicilia Oncology 2 14 600.000 2316858 Effects of repetitive transcranial magnetic stimulation after early stroke: a study in children and developing rats STELLA MARIS Brain Disorders and 14 200.000 Pagina 85 di 142

2317681 Brain complexity and complexity matching for enhancing the positive effects of environmental enrichment on psychopathology Istituto Superiore di Sanita' Integrative, Functional, and Cognitive 14 545.000 2319121 PREDICTION OF AWAKENING FROM ACUTE COMA USING THE BRAIN REACTIVITY TO PAIN RELATED SOMATOSENSORY EVOKED POTENTIALS AND PAIN RELATED FUNCTIONAL BRAIN MAGNETIC RESONANCE. Veneto Brain Disorders and 14 377.700 2321247 Long term efficacy of non pharmacological computer assisted treatment in Alzheimer s Disease and MCI (Mild Cognitive Impairment) patient Lombardia Brain Disorders and 14 275.000 2321024 AN ALTERNATIVE APPROACH TO NICAL MANAGEMENT OF GESTATIONAL DIABETES Lombardia Endocrinology, Metabolism, Nutrition and Reproductive Sciences 14 535.100 2319954 Long term cancer survivors: a comparison between treatments and disease free persons and persons with active disease under therapeutic control. C.R.O. AVIANO Oncology 2 14 600.000 2319558 Randomized Trial Of Cytoreductive Surgery And Hyperthermic Intraperitoneal Chemotherapy Versus Systemic Chemotherapy In Peritoneal Carcinomatosis Arising From Colorectal Cancer ARCISPEDALE Oncology 2 14 280.650 2320637 Anaplastic lymphoma kinase (ALK) gene status assessment to improve treatment of pulmonary sarcomatoid carcinoma, a therapeutically challenging subtype of lung cancer ISTITUTO TUMORI MILANO Oncology 2 14 301.400 2317964 governance and occupational well being: a new organizational approach to healthcare performance Emilia Romagna Healthcare Delivery and 14 170.000 2314546 HIV patient s adherence: a study of predictive factors Lombardia AIDS and Related Research 14 185.000 2305075 The effectiveness of music therapy on depression and on Quality of Life in patients with Amyotrophic Lateral Sclerosis and in post Stroke condition. MAUGERI Healthcare Delivery and 14 262.800 Pagina 86 di 142

2307112 NEW PURINERGIC STRATEGIES TO IMPLEMENT ENDOGENOUS NEUROGENESIS AND RE MYELINATION IN THE REPAIR OF SPINAL CORD INJURY AND BRAIN ISCHEMIA. NEUROLESI Molecular, Cellular, and Developmental 14 600.000 2311106 Role of glucocorticoid induced leucine zipper (GILZ) in autoimmunity Istituto Superiore di Sanita' Immunology 14 600.000 2317154 BiS trial: randomized controlled trial on biologic vs synthetic mesh for the treatment of large defect congenital diaphragmatic hernia. OSPEDALE BAMBINO GESU' Surgical Sciences, Biomedical Imaging, and Bioengineering 14 200.000 2312076 Evaluation of AIFA monitored antineoplastic drugs in advanced cancer patients in the last months of life in Regione Emilia Romagna Emilia Romagna Healthcare Delivery and 14 540.000 2313065 New minimally invasive arthroscopical approach for the treatment and prevention of hip osteoarthritis RIZZOLI Surgical Sciences, Biomedical Imaging, and Bioengineering 14 600.000 2306440 Improving quality of research: a complex intervention trial Emilia Romagna Healthcare Delivery and 14 250.555 2315377 Combined molecular and functional studies to identify novel targets for neuroprotection against brain and spinal cord damage: from bench to bedside. Toscana Brain Disorders and 14 326.000 2314410 IDENTIFICATION OF NEW GENETIC, PROTEIC AND METABOLIC MARKERS TO DISTINGUISH BENIGN FROM MALIGNANT THYROID CELLS. Toscana Genes, Genomes and Genetics 14 300.000 2307159 VENOUS THROMBOEMBOLISM IN FAMILIES WITH INHERITED THROMBOPHILIA: STRATIFICATION OF THE RISK IN THE CARRIER RELATIVES ACCORDING TO THE NICAL PHENOTYPE OF THE PROBAND. IMPLICATIONS FOR FAMILIAL LABORATORY INVESTIGATION OF INDIVIDUALS WITH INHERITED THROM Lazio Population Sciences and Epidemiology 14 187.000 Pagina 87 di 142

2319988 NICAL AND ADMINISTRATIVE WORKLOAD: PHYSICIANS WELLBEING, PERFORMANCE AND CONSEQUENCES ON PATIENT SAFETY. COMPARATIVE ANALYSIS AMONG FIVE IMPORTANT ACUTE HOSPITALS Toscana Risk, Prevention and Health Behavior 14 210.000 2316567 Policystic ovary syndrome and nitric oxide. Effects of the treatment with N acetylcysteine Piemonte Endocrinology, Metabolism, Nutrition and Reproductive Sciences 14 0 2320634 High detection of chronic kidney disease (CKD) in general population by combination of estimated glomerular filtration rate (GFR) and microalbuminuria Puglia Digestive, Kidney and Urological Systems 14 150.000 2305169 Autism Epilepsy: endophenotypic characterization and correlation with astrocyte neuron interaction defects. STELLA MARIS Biobehavioral and Behavioral Processes 14 557.150 2308714 Complex Interventions at Work: comparative analysis of case studies on implementation of process oriented organization of hospital care in community and teaching hospitals Emilia Romagna Healthcare Delivery and 14,17 600.000 2307559 Epigenetic profiles of prognostic markers and therapeutic targets in non small cell lung cancer Emilia Romagna Oncology 1 Basic 14,17 260.000 2315216 HYPOPLASTIC LEFT HEART SYNDROME (HLHS): FROM DISCOVERY OF GENETIC BASIS TO MOLECULAR CLASSIFICATION FOR THERAPEUTIC STRATEGIES Lombardia Genes, Genomes and Genetics 14,25 600.000 2321252 Gio why not? A perspective observational study to improve early diagnosis of andrologic pathologies in young people. Risk, Prevention and Health Behavior 14,25 375.000 2319418 Pancreatic Islet Cell Transplantation for Treatment of Type 1 Diabetes ONCOLOGICO DI BARI Endocrinology, Metabolism, Nutrition and Reproductive Sciences 14,3 600.000 2320065 Identification of new molecular targets in preclinical models of cholangiocarcinoma and in tumor derived xenopatients Piemonte Oncology 2 14,5 150.000 Pagina 88 di 142

2320093 Functional BRAIN CHIP INTEGRATOR (fbci): A pilot study to implement novel rehabilitation strategies through neurochips technology in patients with disorders of consciousness. CARLO BESTA Brain Disorders and 14,5 589.720 2308500 Epidemiology of primary biliary cirrhosis in Lombardia: a validation and geographical clustering study HUMANITAS Population Sciences and Epidemiology 14,5 272.500 2321714 Titanium based third generation biomimetic scaffolds for bone tissue regeneration SAN MATTEO Musculoskeletal, Oral and Skin Sciences 14,5 400.000 2318085 Ring annuloplasty versus Suture repair for the treatment of Not Severe Tricuspid Regurgitation in patients undergoing surgery for Mitral Valve disease: a Prospective, Randomized Study. Surgical Sciences, Biomedical Imaging, and Bioengineering 14,5 250.000 2318322 Electroclinical and genetic characterization of Epilepsy in a population of patients with ring 20 chromosome syndrome. EEG fmri study and comparison with a group of patients with frontal lobe epilepsies (genetic and structural etiologies) Lombardia Brain Disorders and 14,5 75.000 2321459 HIV infected mesenchimal stem cell differentiation: mirna expression profile and role of antiretroviral therapy. Lombardia AIDS and Related Research 14,5 125.000 2321617 Heart failure specialist nurse services (HFSN) Marche Healthcare Delivery and 14,5 200.000 2309590 Peri operative stress in cardiac surgery: psycho social aspects, genetic predisposition and biohumoral characterization Toscana Cardiovascular and 14,5 244.000 2304028 What is better for the therapy of chronic inflammatory demyelinating polyneuropathy? Intravenous Immunoglobulins versus steroids and intravenous immunoglobulins versus sub cutaneous immunoglobulins: a nationwide cost utility study. Piemonte Brain Disorders and 14,5 150.000 2308166 Metabolic syndrome in the etiology and prognosis of hepatocellular carcinoma: a multicentre study. PASCALE Oncology 2 14,5 340.000 Pagina 89 di 142

2316446 New radiotherapic technologies(t): role of hypofractionated(h) Intensity Modulated Image Guided Radiotherapy in Locally Advanced Non Small Cell Lung cancer (Stage IIIA IIIB) Emilia Romagna Oncology 2 14,5 350.000 2317342 Evaluation of neuroendocrine derangements after severe acquired brain injuries: influence on clinical progression and functional recovery during rehabilitation Emilia Romagna Endocrinology, Metabolism, Nutrition and Reproductive Sciences 14,5 300.000 2318714 Exploring the role of the HIV integrase inhibitor Raltegravir as a treatment of Secondary Progressive Multiple Sclerosis. Istituto Superiore di Sanita' Brain Disorders and 14,5 600.000 2314024 Interactive mapping of pathways and targets in renal cancers ISTITUTO TUMORI MILANO Oncology 2 14,5 445.500 2322047 Possibility to calculate the 131I activity based on the desired thyroid mass reduction in the radionuclide therapy of Graves' disease Toscana Endocrinology, Metabolism, Nutrition and Reproductive Sciences 14,5 400.000 2321868 THERAPEUTIC DEVICE OF AREA FOR ADOLESCENCE WITH SEVERE PSYCHIATRIC DISORDERS. PROSPECTIVE STUDY ON EFFICACY. Lombardia Risk, Prevention and Health Behavior 14,5 200.000 2305170 Assessment of strategies for identifying undiagnosed type 2 diabetes mellitus Veneto Population Sciences and Epidemiology 14,5 600.000 2312945 Improving surgical treatment of traumatic nerve injuries by artificial nerve guides: a benefit for the patient and the community Lazio Surgical Sciences, Biomedical Imaging, and Bioengineering 14,5 100.000 2316775 Individual and social effects of a sensitisation campaign on headache Lazio Healthcare Delivery and 14,5 150.000 2319402 The effect of moderate aerobic activity (fitwalking) on the metabolic and cardiovascular complications induced by antiretroviral therapy in patients with HIV infection AIDS and Related Research 14,5 300.000 Pagina 90 di 142

2312729 Neuropsychological, neuropshysiological and neuroimaging markers of progression in prodromal Alzheimer disease (AD): an interdisciplinary approach to the early detection of AD patients SAN RAFFAELE PISANA Biology of Development and Aging 14,5 600.000 2311019 UNMET NEEDS, QUALITY OF LIFE AND FAMILY BURDEN AMONG ICHTHYOSIS PATIENTS ISTITUTO DERMOPATICO DELL'IMMACOLATA Healthcare Delivery and 14,5 159.000 2315830 Integrating ehealth technologies for Patient and General Practitioner Empowerment Lazio Healthcare Delivery and 14,5 470.000 2313309 Risk benefit assessment of cardiovascular drug use in elderly and very old patients affected by cardiovascular disease: a multicentre pharmaco epidemiological study Lazio Healthcare Delivery and 14,5 400.000 2310186 Effect of chemotherapy on ovarian reserve oocytes and role of p63 Lazio Endocrinology, Metabolism, Nutrition and Reproductive Sciences 14,5 400.000 2305398 A multidisciplinary approach to study Frontotemporal lobar degeneration FATEBENEFRATELLI Genes, Genomes and Genetics 14,5 520.000 2299457 GENETIC MODULATION OF COELIAC DISEASE CASA SOLLIEVO SOFFERENZA Digestive, Kidney and Urological Systems 14,5 300.000 2306723 MZN, a new natural herbal compound to combat HIV infection AIDS and Related Research 14,5 330.000 2319956 Identification of novel biomarkers for Renal Cell Carcinoma early diagnosis by peptidome and exosome analysis Puglia Oncology 2 14,5 600.000 2318060 Involvement of mutant p53 gain of function in tumor microenvironment REGINA ELENA Oncology 1 Basic 14,5 180.000 2309494 ROLE OF INFLAMMATION/IMMUNITY IN ATHEROSCLEROSIS: ANALYSIS OF POTENTIAL NOVEL MORPHOLOGIC AND/OR CHEMICAL MARKERS OF PLAQUE PROGRESSION/STABILIZATION SAN RAFFAELE PISANA Vascular and Hematology 14,5 420.000 Pagina 91 di 142

2317166 Udder and milk changes during mycoplasma mastitis in sheep: identification of humoral and cellular indicators for clinical/disease staging and vaccine efficacy Istituto Zooprofilattico Sperimentale della Sicilia Veterinary 14,5 340.000 2312593 Influence of metabolic factors on inflammation of colorectal mucosa in colorectal cancer risk assessment Emilia Romagna Oncology 2 14,5 185.500 2306140 The role of C1 (Chloride channel 1) in the tumorigenicity of glioblastoma cancer stem cells I.E.O. Oncology 1 Basic 14,5 472.000 2307035 Randomized pilot phase II study of Lenalidomide as adjuvant therapy for prevention of Hepatocellular carcinoma (HCC) recurrence after radiofrequency thermal ablation (RFA): molecular and immunological prognostic biomarkers Emilia Romagna Oncology 2 14,5 550.000 2316386 Growth and oncolytic properties of Influenza A viruses in human pancreatic tumour cells and animal models Istituto Zooprofilattico Sperimentale delle Venezie Infectious Diseases and Microbiology 14,5 560.000 2315751 From sarcoma genetics and genomics to novel diagnostic and therapeutic strategies: a deep sequencing approach C.R.O. AVIANO Oncology 1 Basic 14,5 580.000 2314798 Advanced personal and environmental teledosimetry system Toscana Surgical Sciences, Biomedical Imaging, and Bioengineering 14,5 480.000 2309321 Sensorimotor Integration. Physiology and Pathophysiology MAUGERI Integrative, Functional, and Cognitive 14,5 279.860 2317236 Application of new PET tracers for early imaging of radiation induced lung fibrosis in a mouse model Toscana Oncology 2 14,5 325.000 2315624 Novel assays for the diagnosis of scleroderma Marche Immunology 14,5 300.000 2312640 Characterization of HIV related mechanisms involved in the development of Burkitt s lymphoma Emilia Romagna AIDS and Related Research 14,5 300.000 Pagina 92 di 142

2317764 DEVELOPMENT OF A METHOD FOR NON INVASIVE ROUTINE PRENATAL DIAGNOSIS OF MONOGENIC DISORDERS USING CELL FREE DNA IN MATERNAL PLASMA Veneto Genes, Genomes and Genetics 14,5 250.000 2321943 An integrated pharmacogenetic approach to the optimization of adjuvant hormonal treatment of estrogen receptor positive breast cancer Toscana Oncology 2 14,5 320.000 2313415 Breast Cancer targeting through innovative drug delivery systems. IRCCS AOU San Martino IST (Genova) Oncology 2 14,5 495.000 2314960 Nd:YAG laser ablation for mininvasive endoscopic treatment of pancreatic neoplastic lesions: from animal model to human application Lazio Surgical Sciences, Biomedical Imaging, and Bioengineering 14,5 556.650 2314566 Biomolecular Markers Involved in the Development of Hepatitis Virus Infections Associated Lymphomas: A Multicentric Case Control Study C.R.O. AVIANO Oncology 2 14,5 410.000 2319679 THE DOMOTIC GERIATRICS UNIT (DOMO_GER): AN INTELLIGENT SENSOR NETWORK FOR THE PREVENTION OF NEGATIVE OUTCOMES (DELIRIUM, FALLS, SUDDEN DEATH) IN HOSPITALIZED OLDER PATIENTS. Veneto Bioengineering Sciences and Technologies 14,5 350.000 2307790 Genome Remodeling in Luminal B and Ductal Triple Negative Breast Cancer Metastasis and Xenograft: Exome sequencing analysis for identification of driver pathways to overcome resistance I.E.O. Oncology 2 14,5 445.000 2312503 Mathematical modelling of mosquito borne diseases in Italy Istituto Superiore di Sanita' Population Sciences and Epidemiology 14,75 307.000 2313734 POST TRANSCRIPTIONAL REGULATION AND MITOCHONDRIAL LOCALIZATION OF BRCA1 IN HUMAN BREAST CANCER ONCOLOGICO DI BARI Oncology 1 Basic 14,75 574.000 2312973 Surveillance of the circulation of rotaviruses in the infantile population of Sicily in view of the introduction of rotavirus vaccination. Sicilia Infectious Diseases and Microbiology 14,75 365.000 Pagina 93 di 142

2321846 The use of a numerical model of the cardiovascular system to personalize and optimize cardiac resynchronization therapy (CRT) Lazio Cardiovascular and 15 240.000 2313431 ROLE OF COLECALCIPHEROL IN THE TREATMENT OF MILD COGNITIVE IMPAIRMENT. Piemonte Brain Disorders and 15 180.000 2318876 Personalized and optimized Road Map of effective integration between intensive medical treatment and secondary liver surgery in liver limited metastatic colorectal cancer (MCRC) through biomolecular characterization. Abruzzo Oncology 2 15 200.000 2319807 Evaluation of the role of CD 133+/CD44+ colorectal TICs in patterns of metastatization and possible subsequent their clinical investigation ONCOLOGICO DI BARI Oncology 2 15 298.900 2315932 Targeted resequencing of genomic regions by next generation sequencing technologies GASLINI Genes, Genomes and Genetics 15 450.000 2316193 Identification of mirna based Therapeutical Targets in Gliomas by Integrated Genomic Analyses. CASA SOLLIEVO SOFFERENZA Oncology 1 Basic 15 550.000 2314877 Early onset anorexia nervosa: the role of hyperactivity as predictor of outcome STELLA MARIS Risk, Prevention and Health Behavior 15 240.000 2319837 Gender specific oncology: psychoncology s contribution to global care and rehabilitation of young adult male and female patients C.R.O. AVIANO Oncology 2 15 730.000 2310475 11C Choline PET/CT as Image Guide for radiotherapic treatment of prostate cancer recurrent lymphnodes Oncology 2 15 300.000 2304875 Development, implementation and evaluation of a population based informational and educational package to improve knowledge on palliative care. A quasiexperimental study in the Liguria Region. IRCCS AOU San Martino IST (Genova) Healthcare Delivery and 15 560.000 2312725 Telemonitoring in long term ventilator dependent patients: a multicenter randomized controlled study Toscana Cardiovascular and 15 209.000 Pagina 94 di 142

2306323 SAFETY AND TOLERABILITY OF SECOND GENERATION ANTIPSYCHOTICS IN CHILDREN AND ADOLESCENTS: A PROACTIVE/PROSPECTIVE PHARMACHOVIGILANCE STUDY MEDEA Biobehavioral and Behavioral Processes 15 600.000 2309398 Early detection of lung cancer in asymptomatic high risk population by low dose CT scan and molecular markers. I.E.O. Oncology 2 15 600.000 2316031 Title: Developing and Evaluation of innovative methods for detecting and trace infective pathogens in foods: molecular correlation with human cases Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia Veterinary 15 490.000 2307812 Sarcopenic obesity in hospitalized older persons: prevalence, associations with the geriatric syndrome of frailty, and effect on clinically relevant adverse health outcomes Emilia Romagna Biology of Development and Aging 15 150.000 2316585 New perspectives in colorectal cancer for early diagnosis and therapy ONCOLOGICO DI BARI Oncology 1 Basic 15 456.000 2310090 Use of Tranexamic acid in elective orthopaedic prosthetic surgery for preventing blood loss. Veneto Surgical Sciences, Biomedical Imaging, and Bioengineering 15 150.000 2320072 Role profiles and clinical competencies: a new approach for healthcare workforce Emilia Romagna Healthcare Delivery and 15 250.000 2320313 NEW INSIGHTS FOR CAD PATIENT MANAGEMENT: in vivo assessment of coronary plaque morphology by means of OCT images and biohumoral markers (PLIMAB: PLaque IMAging Biomarkers) Toscana Cardiovascular and 15 516.666 2321587 implementation of Adaptive Radiotherapy (ART) head and neck cancer. Evaluation of ART IMRT potential in reducing xerostomia and dysphagia. I. O. V. Oncology 2 15 235.000 2320747 Multiple Chronic Conditions Prevalence, Care Management, Implications for Quality, and Health Costs Lombardia Healthcare Delivery and 15 458.000 Pagina 95 di 142

2321034 RANDOMIZED CONTROLLED TRIAL OF MULTIDIMENSIONAL STIMULATION THERAPY IN PRODROMAL TO MODERATE STAGES OF ALZHEIMER'S DISEASE: NICAL, FUNCTIONAL MRI ASSESSMENT AND COST EFFECTIVENESS ANALYSIS. DON GNOCCHI Brain Disorders and 15 600.000 2321134 Longitudinal, comprehensive, integrated study of outcome in patients with prolonged disorders of consciousness (DOC) MAUGERI Brain Disorders and 15 380.000 2321094 CT scan evaluation of vertebral body derotation in adolescent idiopathic scoliosis surgery RIZZOLI Surgical Sciences, Biomedical Imaging, and Bioengineering 15 40.000 2321339 How to evaluate Efficacy In the framework of costeffectiveness analysis for Growth Hormone (rhgh) Therapy in paediatric patients with Growth Hormone deficiency Piemonte Healthcare Delivery and 15 270.000 2313107 Relationship between biomarkers, diastolic left ventricular recoil reserve measurement and ventriculararterial coupling to improve diagnosis and risk stratification in diastolic heart failure. Umbria Cardiovascular and 15 249.760 2318433 The challenge of risk stratification in cardiac surgery: the ACEF PLUS to catch extreme conditions SAN DONATO Risk, Prevention and Health Behavior 15 150.000 2310904 Establishing the early profile of chronic renal allograft dysfunction with functional magnetic resonance and contrast enhanced ultrasound Surgical Sciences, Biomedical Imaging, and Bioengineering 15 400.000 2315532 EXTRACORPOREAL PHOTOCHEMOTHERAPY IN THE TREATMENT OF ERYTHRODERMIC CUTANEOUS T CELL LYMPHOMA: NICAL ACTIVITY, TOXICITIES, QUALITY OF LIFE IMPROVEMENT AND RESPONSE ASSOCIATED LOGICAL MARKERS Piemonte Oncology 2 15 240.000 2310382 Prevalence of risk factors for cardiovascular and non viral hepatic diseases: an epidemiological study in two Italian populations Istituto Superiore di Sanita' Population Sciences and Epidemiology 15 173.800 Pagina 96 di 142

2314288 Study of the interaction between polyomavirus JC (JCV) and stem cells Toscana Infectious Diseases and Microbiology 15 400.000 2307684 Mechanisms of the antitumor activity of HIV protease inhibitors treatment in HIV negative patients affected by classical Kaposi s sarcoma or cervical intraepithelial neoplasia Istituto Superiore di Sanita' Oncology 2 15 600.000 2306037 Producing ips cells: a biobank service for translational genetic research Liguria Genes, Genomes and Genetics 15 477.000 2318951 ADJUSTING THE ENVIRONMENTAL CONTEXT TO IMPROVE SEROTONINERGIC ANTIDEPRESSANT EFFICACY Istituto Superiore di Sanita' Biobehavioral and Behavioral Processes 15 581.000 2303787 ARTEMIS (Augmented Realism in Teleconsulting and Education in MinimallyInvasive Surgery) Toscana Surgical Sciences, Biomedical Imaging, and Bioengineering 15 594.000 2312123 TRANSMISSION OF SPORADIC CREUTZFELDT JAKOB DISEASE BY BLOOD: EPIDEMIOLOGICAL AND EXPERIMENTAL TRANSMISSION STUDIES Istituto Superiore di Sanita' Population Sciences and Epidemiology 15 500.000 2319706 Role of oncogene induced senescence in thyroid carcinogenesis ISTITUTO TUMORI MILANO Oncology 1 Basic 15 400.000 2320442 Viral respiratory tract infections in infants and young children: the IFNs/CD38/Ectonet axis as possible therapeutic target. Istituto Superiore di Sanita' Immunology 15 569.800 2316601 Unraveling the fingerprint of a new subset of human tolerogenic dendritic cells Immunology 15 454.000 2317568 Isolation and characterization of mesenchymal stem cells: therapeutic implications for cardiac disease Emilia Romagna Cardiovascular and 15 327.777 2310052 Research of biomarkers in peripheral blood and tissue specimens for early diagnosis and prediction of therapy response in patients with colorectal cancer. Emilia Romagna Oncology 2 15 478.245 Pagina 97 di 142

2311326 Danger associated molecular patterns: revealing the molecular signals dictating the communication between dying cells with the immune system Istituto Superiore di Sanita' Oncology 2 15 600.000 2320815 Exposure to low arsenic concentrations via drinking water and health effects in 91 municipalities of the Lazio region, Italy Lazio Population Sciences and Epidemiology 15 600.000 2311054 Identification of biomarkers for an early diagnosis of periprosthetic osteolysis Piemonte Musculoskeletal, Oral and Skin Sciences 15 285.000 2311792 Abscisic acid, a new endogenous modulator of insulin release and glucose uptake: pre clinical studies of its use to improve the clinical assessment and design novel therapies for diabetes mellitus. IRCCS AOU San Martino IST (Genova) Endocrinology, Metabolism, Nutrition and Reproductive Sciences 15 337.000 2319082 Ingestible device for the intragastric treatment of Helicobacter pylori infection Toscana Infectious Diseases and Microbiology 15 420.000 2320705 A translational approach to hypertrophic cardiomyopathy: new therapeutic targets for a personalized drug therapy Toscana Cardiovascular and 15 450.000 2315598 Nanoparticles engineered with antibody derivatives or other molecules recognizing markers overexpressed in tumor cells: breast cancer targeting and biodistribution Lombardia Bioengineering Sciences and Technologies 15 344.000 2318325 Prevention interventions for promoting the health of men who have sex with men (MSM) in Palermo area. Sicilia Risk, Prevention and Health Behavior 15 175.000 2314252 Bio Molecular markers in the secondary prevention, diagnosis, prognosis and personalized therapy of hepatocellular carcinoma. Veneto Oncology 2 15 250.000 2319096 strategy for developing rationale combinations of molecularly targeted agents in patients with non Hodgkin lymphoma (NHL) and Hodgkin lymphoma (HL) HUMANITAS Oncology 2 15 600.000 Pagina 98 di 142

2318985 Next generation approaches to identify novel pathophysiological mechanisms of coronary intra stent thrombosis and intra stent restenosis Toscana Cardiovascular and 15 550.000 2312022 Ensuring the safety of human stem cells: evaluation of genomic stability and metrological assessment of regenerative medicine products Piemonte Genes, Genomes and Genetics 15 400.000 2313492 Role of Copy Number Variations in determining the individual susceptibility to essential hypertension AUXOLOGICO Cardiovascular and 15 515.900 2311467 Long term immune monitoring of patients with psoriasis or psoriatic arthritis treated with drugs targeting key mediators of the immune response to identify key parameters of therapeutic efficacy and/or disease progression SAN GALLICANO Immunology 15 250.000 2322008 Association between Chronic Obstructive Pulmonary Disease and lung cancer: mechanisms of immune regulation Veneto Cardiovascular and 15 500.000 2314431 Innovative analytical procedures and rapid diagnostic methods for the assessment of hygienic sanitary status of the fishery and mariculture production chains for the presence of emerging organic and inorganic micropollutants and emerging zoonotic pathoge Istituto Zooprofilattico Sperimentale del Mezzogiorno Veterinary 15 600.000 2317559 Development and exploitation of a platform able to produce antibody based reagents. From monoclonal murine antibody to completely human reagent using protein engineering to raise new potent diagnostic and therapeutic tools in oncology ISTITUTO TUMORI MILANO Oncology 2 15 512.001 2319644 Genome wide SNP identification for high resolution molecular genotyping of Listeria monocytogenes Istituto Zooprofilattico Sperimentale della Puglia e della Basilicata Infectious Diseases and Microbiology 15,33 540.000 2312541 Functional and viability impairment of cardiomyocytes in familial amyloid polyneuropathy Toscana Cardiovascular and 15,33 322.000 Pagina 99 di 142

2311534 Novel strategies in the pathogenesis, epidemiology and prognostic factors of papillary thyroid cancer Toscana Endocrinology, Metabolism, Nutrition and Reproductive Sciences 15,5 450.000 2309568 2316035 Genetic predisposition to severe and recurrent infections: unravelling the pathogenic mechanisms of susceptibility EVALUATION OF HUMORAL AND CELLULAR REACTIVITY IN KIDNEY ALLOGRAFT PATIENTS: NEW TOOL TO TRIM THE IMMUNOSUPPRESIVE THERAPY IN ACCORDING TO THE AGE SAN MATTEO Immunology 15,5 480.000 Piemonte Immunology 15,5 400.000 2314655 A multidisciplinary approach to personalized medicine in CRC Sicilia Oncology 2 15,5 595.000 2314344 Effects of an educational intervention for reducing inappropriate prescribing in elderly exposed to polypharmacy in general practice Lombardia Healthcare Delivery and 15,5 450.200 2310894 Molecular subtype based follow up program in patients treated for early breast cancer Emilia Romagna Oncology 2 15,5 450.000 2320345 Calcium sensitizer agents for improving organs protection in transplants. Piemonte Surgical Sciences, Biomedical Imaging, and Bioengineering 15,5 110.000 2315569 Calcific arteriopathy in chronic kidney disease: genetic determinants, molecular biology and clinical markers Biology of Development and Aging 15,5 600.000 2316281 UPPER LIMB IMPAIRMENT IN CHARCOT MARIE TOOTH PATIENTS: MOTOR STRATEGIES, IMPACT ON QUALITY OF LIFE AND CORTICAL FUNCTIONAL REORGANIZATION DON GNOCCHI Musculoskeletal, Oral and Skin Sciences 15,5 450.000 2298972 Role of local synthesis and of systemic administration of Brain Derived Neurotrophic Factor (BDNF) in the striatum of the murine model of Huntington s disease. SANTA LUCIA Brain Disorders and 15,5 300.000 Pagina 100 di 142

2308521 Assessment of the role of image guided radiotherapy (IGRT) in the treatment of head and neck cancers. A randomized phase III study of chemo radiation for stage III IVa oropharynx cancers: IGRT Intensity Modulated Radiotherapy (IMRT) with dose fraction esc ARCISPEDALE Oncology 2 15,5 350.000 2316393 POSSIBLE ROLE OF 18F FDG PET/CT IN DEFINING THE APPROPRIATE USE OF PRRT IN PATIENTS WITH METASTATIC GEP NETs WITH EVIDENCE OF TUMOUR PROGRESSION FOLLOWING TREATMENT WITH SOMATOSTATIN ANALOGUES. ISTITUTO TUMORI MILANO Oncology 2 15,5 468.600 2318086 The burden of arterial and venous thromboembolism in the Italian active population: a twenty years long prospective VITA (VIcenza Thrombophilia and Atherosclerosis) COhort STudy (VITA COST) Veneto Vascular and Hematology 15,5 280.000 2311365 Non invasive assessment of liver steatosis and fibrosis, and lymph nodes diseases in pediatric patients. SAN MATTEO Surgical Sciences, Biomedical Imaging, and Bioengineering 15,5 450.000 2319987 Homocysteine serum levels in patients with cutaneous lupus erythematosus: pathogenetic and therapeutic implications. Toscana Musculoskeletal, Oral and Skin Sciences 15,5 160.000 2321999 Prevention of recurrence of idiopathic calcium stones and risk of developing associated diseases: a study of saltsensitivity genetics, urinary phenotype risk and body composition. Emilia Romagna Digestive, Kidney and Urological Systems 15,5 180.000 2320228 HIV STDs coinfection in treated MSM patients: measurement of plasmatic and seminal HIV Viral Load Lombardia Infectious Diseases and Microbiology 15,5 150.000 2316795 Interim FDG PET/CT in the assessment of early response to concurrent chemo radiotherapy in patients with nonsmall cell lung cancer stage IIIA IIIB ARCISPEDALE Oncology 2 15,5 190.000 2310730 Genetic polymorphisms in genes of drug related and DNA repair pathways as predictive markers of the therapeutic efficacy in esophageal carcinoma. I. O. V. Oncology 2 15,5 240.000 Pagina 101 di 142

2304835 D.A.I.P.P. Assessment of influencing factors in diabetes incidence and progression in paediatric immigrant population Piemonte Healthcare Delivery and 15,5 245.000 2318318 ROLE OF HUMAN PAPILLOMAVIRUS IN THE DEVELOPMENT OF PENILE CANCER IN PATIENTS WITH LICHEN SCLEROSUS: NICAL, VIDEODERMATOSCOPIC, HISTOPATHOLOGIC AND MOLECULAR STUDY Sicilia Oncology 1 Basic 15,5 270.000 2319567 Innovative biomarkers for prevention, diagnosis and prognosis of colorectal cancer ARCISPEDALE Oncology 2 15,5 514.000 2315051 Resistin as a biomarker of coronary artery disease, major cardiovascular events and all cause mortality in patients with type 2 diabetes. CASA SOLLIEVO SOFFERENZA Vascular and Hematology 15,5 210.000 2310448 Role of extracellular Tat in HIV infection Istituto Superiore di Sanita' AIDS and Related Research 15,5 333.333 2312283 High resolution array CGH study in patients with infancy epileptic encephalopathies of unknown etiology. OASI MARIA S.S. Brain Disorders and 15,5 420.000 2307444 Na+ Ca2+ exchanger 1 (NCX1) as new potential therapeutic target in the management of bacteriainduced heart hypertrophy and related complications Marche Cardiovascular and 15,5 575.000 2320959 Role of polymorphisms of genes involved in alloreactive response in kidney transplantation: implications for personalized post transplant therapies Abruzzo Immunology 15,5 429.000 2313328 Imaging and molecular analysis of brain inflammation in depression: a translational approach Brain Disorders and 15,5 550.000 2306708 Development of an easily available Monte Carlo based tool to improve dose delivery accuracy in helical tomotherapy Istituto Superiore di Sanita' Oncology 2 15,5 600.000 Pagina 102 di 142

2311688 ANORECTAL MALFORMATIONS (ARM): A MULTIDISCIPLINARY RESEARCH TO IDENTIFY PREDISPOSING FACTORS AND NEW THERAPEUTICAL APPROACHES Veneto Genes, Genomes and Genetics 15,5 475.000 2318842 The Salivary Proteomics biomarkers for Alzheimer's disease study (SaP AD study) Sicilia Brain Disorders and 15,5 600.000 2317368 Allergic contact dermatitis to nickel and related alloys SAN GALLICANO Cardiovascular and 15,5 380.000 2316975 High throughput sequencing to reveal the undesired microbiota in raw cheeses Istituto Zooprofilattico Sperimentale del Mezzogiorno Veterinary 15,5 550.000 2321292 Detailed virological characterisation of patients with virological failure receiving integrase inhibitors and/or CCR5 inhibitors: RNA and DNA resistance profile, plasma and cell viral load, V3 loop characterisation and pharmacokinetic profile Istituto Superiore di Sanita' AIDS and Related Research 15,5 380.000 2319421 Liver Factory SAN MATTEO Surgical Sciences, Biomedical Imaging, and Bioengineering 15,5 470.000 2319469 Vibrio and viruses in shellfish: old and emerging pathogens. Evaluation of exposure levels for the implementation of prevention strategies. Istituto Zooprofilattico Sperimentale del Mezzogiorno Veterinary 15,5 400.000 2311662 Development and preclinical testing of novel adenosine 2A receptor antagonists for the treatment of Parkinson s disease and clinical implementation of potential adenosine receptor related biomarkers MONDINO Brain Disorders and 15,5 560.000 2318110 Novel approaches to the functional characterization of unclassified variants in BRCA genes. ISTITUTO TUMORI MILANO Oncology 1 Basic 15,5 298.650 2305356 Urinary FDG loss and measurement of standardized uptake value "SUV" IRCCS AOU San Martino IST (Genova) Surgical Sciences, Biomedical Imaging, and Bioengineering 15,5 203.000 Pagina 103 di 142

2318972 Food pyramids and nutritional prevention campaigns CROB Healthcare Delivery and 15,5 500.000 2317071 Mice models of osteosarcoma and hemangiosarcoma development. Early molecular and immunological mechanisms involved in tumor onset and malignancy as targets of innovative therapies. RIZZOLI Oncology 1 Basic 15,75 260.000 2315123 FACES IV: A DIAGNOSTIC INSTRUMENT TO EVALUATE FAMILY FUNCTIONING IN A SAMPLE OF PATIENTS IN THE PEDIATRIC AGE OSPEDALE BAMBINO GESU' Biobehavioral and Behavioral Processes 15,75 150.700 2318438 PROBING THE ROLE OF ION CHANNELS IN NEUROPATHIC PAIN CARLO BESTA Molecular, Cellular, and Developmental 15,8 600.000 2309530 INNOVATIVE TREATMENTS FOR NEUROGENETIC DISEASES AND THEIR COMPLICATIONS: ATAXIA TELANGIECTASIA Lazio Genes, Genomes and Genetics 15,83 115.000 2321537 Prevalence and clinical impact of Chronic Obstructive Pulmonary Disease (COPD) in patients with cardiovascular disease and predictive power of cardiovascular risk factors in patients with COPD SAN RAFFAELE PISANA Cardiovascular and 16 450.000 2305498 Folic acid assumption in late pregnancy and its interaction with parental and fetal genes in childhood asthma development Istituto Superiore di Sanita' Population Sciences and Epidemiology 16 286.000 2301332 Epidemiology, Biomolecular Characterization, Phylogenetic Analysis, and Evaluation of Urine Testing Strategy for Diagnosis of Chlamydia and HPV Infections in Migrant Women with Limited Access to Health Care Lombardia Infectious Diseases and Microbiology 16 292.100 2310895 Cardiac output regulation in artificial hearts MONZINO Cardiovascular and 16 299.200 2318009 Cardiotoxicity of anticancer treatments. Biomarkers and diagnostic tools for evaluation of cardiological risk of oncological patients MULTIMEDICA Cardiovascular and 16 499.844 Pagina 104 di 142

2312694 Maternal metabolic hormones impact on human breast during pregnancy. Abruzzo Endocrinology, Metabolism, Nutrition and Reproductive Sciences 16 220.000 2320428 Role of nicotinic receptor subtypes in alcohol tobacco dependence Emilia Romagna Genes, Genomes and Genetics 16 600.000 2313742 A MULTIDISCIPLINARY EMERGENCY APPROACH TO IMPROVE QUALITY OF CARE AND REDUCE POST TRAUMATIC STRESS DISORDER IN CHILDREN Emilia Romagna Healthcare Delivery and 16 240.000 2313066 One year follow up of infected fetuses.1) Implementation of clinical pathways for an appropriate/comprehensive care of women infected during pregnancy and of infants with congenital infection.2) Role of innate immunity in the susceptibility to infect OSPEDALE BAMBINO GESU' Infectious Diseases and Microbiology 16 600.000 2310212 INTERMEDIATE INTENSIVE CARE UNIT (IICU CRITICAL AREA ) Emilia Romagna Healthcare Delivery and 16 409.000 2311423 Evaluation of CARDIac function in patients with chronic LIVER disease (CARDIO LIVER) Toscana Surgical Sciences, Biomedical Imaging, and Bioengineering 16 436.600 2312095 Rehabilitation in Chronic Disability: Connecting Care 2.0 Lombardia Healthcare Delivery and 16 300.000 2312711 Ultraviolet solar radiation and aromatic hydrocarbons as carcinogenic factors in outdoor workplaces: exposure quantification and biomarkers identification aimed at the identification of principal effects and possible synergistic effects Ist. Sup. per la Prevenzione e Sicurezza sul Lavoro Population Sciences and Epidemiology 16 497.572 2304828 TRAIL producing UC MSCs as cytotherapy to defeat multiple myeloma: a preclinical study. ONCOLOGICO DI BARI Oncology 2 16 499.000 2308966 Effect of eyes covering on variations of melatonin secretion, electroencephalographic pattern and outcome in patients with severe neurological damage. Emilia Romagna Brain Disorders and 16 500.000 Pagina 105 di 142

2301784 Pharmacological enhancement of tumor cell death by soluble or membrane bound TRAIL and SMAC mimetics ISTITUTO TUMORI MILANO Oncology 1 Basic 16 580.000 2315859 MicroRNA regulation in the pathogenesis of MD and in the mechanism of action of antidepressant drugs FATEBENEFRATELLI Biobehavioral and Behavioral Processes 16 600.000 2315143 Extraneuronal airway cholinergic system and ß2ARs function in stable COPD and control subjects Emilia Romagna Cardiovascular and 16 150.000 2302378 "Leading nanomedicine into the therapy for Leukodystrophies: nanoparticles overcoming the bloodbrain barrier to treat the mouse model of Krabbe Disease" BURLO GAROFALO Molecular, Cellular, and Developmental 16 380.000 2315894 Bone Morphogenetic Protein pathway induces Cancer Stem Cells differentiation enhancing the chemosensitivity of breast and colorectal cancers to conventional chemotherapy Sicilia Oncology 2 16 400.000 2321051 management of viral infections in pediatric hematopoietic stem cell transplant recipients. Piemonte Infectious Diseases and Microbiology 16 150.000 2309735 Identification of organs that are reservoir of immunosoppressive cells during tumor development and progression Immunology 16 509.000 2315144 Extracorporeal lung perfusion and ventilation to improve donor lung function and increase the number of organs available for transplantation. MAGGIORE Cardiovascular and 16 380.000 2306484 Human infection from exposure to norovirus: improving diagnostic techniques and correlation analysis between clinical cases and infected food. Developing a network among hospital units and IIZZSS in some Italian regions Istituto Zooprofilattico Sperimentale delle Venezie Infectious Diseases and Microbiology 16 600.000 2313948 Overweight, Obesity and Risk of Western Disease(WD): a cohort prospective study in a mediterranean area DE BELLIS Population Sciences and Epidemiology 16 210.000 2319291 Role of regulatory cells and cytokines in the extent of colonic involvement in patients with ulcerative colitis Istituto Superiore di Sanita' Digestive, Kidney and Urological Systems 16 599.500 Pagina 106 di 142

2314686 Epigenetic determinants of psoriasis and psoriatic arthritis: diagnostic and prognostic values of DNA methylation patterns Emilia Romagna Musculoskeletal, Oral and Skin Sciences 16 595.000 2321531 Evaluation of the pharmaco/toxicological profile of new smart drugs of abuse and optimization of targeted analytical procedures for their detection in biological samples Toscana Risk, Prevention and Health Behavior 16 500.000 2321390 Nanomedicine applied to cerebral ischemia NEUROLESI Brain Disorders and 16 600.000 2321689 Quitline for smoking cessation in women adhering cervical cancer screening Piemonte Risk, Prevention and Health Behavior 16 400.000 2317708 Intraoperative Calcitonin Monitoring as marker of disease cure after surgery and indicator of type of surgery in patients with Medullary Thyroid Cancer PASCALE Oncology 2 16 150.000 2307536 MicroRNA regulation of cellular signalling pathways: Identification of prognostic and therapeutic biomarkers in high risk soft tissue sarcoma patients RIZZOLI Oncology 1 Basic 16 400.000 2314408 and molecular mechanisms of accelerated aging in dialysis patients. Abruzzo Biology of Development and Aging 16,25 376.000 2314905 Therapeutic heart rate lowering in coronary artery disease patients and endothelial shear stress: the likely beneficial link MAUGERI Cardiovascular and 16,25 425.000 2311911 NEW MOLECULAR APPROACHES FOR THE DETECTION OF DIOXINS AND DIOXIN LIKE COMPOUNDS IN EXPOSED SHEEP Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta Veterinary 16,5 600.000 2312677 A Multi center 3T MR Assessment of T2 Perfusion and T1 Permeability in brain Gliomas: the MAPPING study Oncology 2 16,5 500.000 2320210 Near infrared technology for trafficking the fate of stem cells in vivo: a translational study for longitudinal tracking in a rodent model of Parkinson s disease AUXOLOGICO Emerging Technologies and Training in s 16,5 598.000 Pagina 107 di 142

2313256 CCRL2 as a new therapeutic target in rheumatoid arthritis HUMANITAS Immunology 16,5 550.000 2308881 Study of cerebral glucose metabolism by means of positron emission tomography (PET) in psoriatic patients with and without depression major before and after effective anti psoriatic therapies SAN GALLICANO Musculoskeletal, Oral and Skin Sciences 16,5 480.000 2315622 MOLECULAR CHARACTERIZATION OF COXIELLA BURNETII ISOLATES BY RAPD AND MLVA ANALYSES Istituto Zooprofilattico Sperimentale del Mezzogiorno Veterinary 16,5 400.000 2317363 PROTIC TREATMENT TO PREVENT ALLERGEN SENSITIZATION: A PRENICAL STUDY IN PREGNANT AND NEWBORN MICE Istituto Superiore di Sanita' Immunology 16,5 525.800 2320073 PHARMACOGENETICS OF PEMETREXED AND CARBOPLATIN IN MALIGNANT PLEURAL MESOTHELIOMA (MPM) PATIENTS. HUMANITAS Oncology 2 16,5 409.000 2320713 and experimental investigations of novel disease mechanisms in pain processing and Parkinson Disease MONDINO Brain Disorders and 16,5 550.000 2313912 Salivary gland tumours: molecular and molecularcytogenetic studies to identify diagnostic/prognostic markers and risk factors Istituto Superiore di Sanita' Genes, Genomes and Genetics 16,5 201.300 2307416 Development of an innovative strategy based on the use of lytic bacteriophages for an effective and safe treatment of irrigation and washing waters of crops Istituto Zooprofilattico Sperimentale del Mezzogiorno Veterinary 16,5 575.000 2316069 TRANSLATIONAL APPLICATIONS ENSUING CIRCULATING IMMUNOCOMPLEXES AND NICAL APPROACHES IN GASTRIC CARCINOMA THAT PROVIDE INFORMATIVE CLUES FOR EARLY DIAGNOSIS AND TREATMENT OF GASTRIC CANCER C.R.O. AVIANO Oncology 2 16,5 550.000 2306837 Search for new mutations and polymorphisms of FSHR and LHR genes in hypergonadotropic hypogonadic patients without obvious testicular pathogenic noxa. Toscana Endocrinology, Metabolism, Nutrition and Reproductive Sciences 16,5 183.000 Pagina 108 di 142

2311488 High throughput parallel sequencing of Mycobacterium avium subsp. paratuberculosis in sheep, of affected/non affected sheep transcriptome and of environmental samples. Istituto Zooprofilattico Sperimentale del Lazio e della Toscana Veterinary 16,5 350.000 2317030 Detection of Mycobaceterium avium subsp. paratuberculosis in human Crohn s disease and in ruminants and possible role of contaminated food Istituto Zooprofilattico Sperimentale del Mezzogiorno Infectious Diseases and Microbiology 16,5 600.000 2313248 The pathogenetic role of serotonin and cytokines and the influence of nutritional and vitamin D deficiency on alterations of bone mineral metabolism in young women with chronic bowel diseases: a pilot study. AUXOLOGICO Endocrinology, Metabolism, Nutrition and Reproductive Sciences 16,5 484.000 2318391 PGD in genetic alteration and repeated failures in IVF patients Toscana Endocrinology, Metabolism, Nutrition and Reproductive Sciences 16,5 516.000 2317952 A pharmacogenomic approach for Interferons treatment in multiple sclerosis Brain Disorders and 16,5 600.000 2309778 PAIN AND ANALGESIA IN THE PRETERM NEWBORN: A LONGITUDINAL STUDY ON NON PHARMACOLOGIC METHODS EFFICACY AND THEIR INFLUENCE ON PAIN PROCESSING CORTICAL MATURATION BURLO GAROFALO Brain Disorders and 16,5 275.000 2317464 Development and validation of a set of indicators based on administrative data to monitor long term care for disabled elderly Agenzia per i Servizi Sanitari Regionali Healthcare Delivery and 16,5 550.000 2318207 Detection and management of Thyroid nodules: assessment of a screening program carried out by General Practitioners ARCISPEDALE Healthcare Delivery and 16,5 187.000 2311634 Multidisciplinary vs Monodisciplinary Clinic for Prostate Cancer Patients: Evaluating Patients Satisfaction and Multidisciplinary Team Working ISTITUTO TUMORI MILANO Healthcare Delivery and 16,5 189.500 Pagina 109 di 142

2306088 EasyHIFU: simplified lesion localization for HIFU treatment Toscana Surgical Sciences, Biomedical Imaging, and Bioengineering 16,5 298.000 2312357 The role of diet in psoriasis ISTITUTO DERMOPATICO DELL'IMMACOLATA Risk, Prevention and Health Behavior 16,5 297.000 2308327 Therapeutic targeting of HSP105 in human non Hodgkin lymphomas ISTITUTO TUMORI MILANO Oncology 2 16,5 360.000 2317170 Prognostic role of arterial stiffness and vascular calcifications on peripheral arterial occlusive disease in chronic kidney disease. A multi center, observational, prospective, non invasive study. AUXOLOGICO Vascular and Hematology 16,67 573.320 2319416 Performance of serum SMRP as screening tool (the cancer predictive values of SMRP ) surveilling a cohort of asbestos exposed individuals Liguria Oncology 2 16,75 125.000 2316361 Physiopathological mechanisms of freezing of gait in Parkinson disease and development of rehabilitative therapeutic strategies S.CAMILLO Brain Disorders and 16,75 200.000 2316009 Oxidative stress in animals cancer stem cells: biological mechanisms involved in the pathogenesis of mammary spontaneous tumours Istituto Zooprofilattico Sperimentale del Piemonte, Liguria e Valle d'aosta Veterinary 17 410.000 2316787 Guided bone regeneration with innovative degradable scaffolds RIZZOLI Musculoskeletal, Oral and Skin Sciences 17 305.000 2307784 New prognostic markers and therapies for Merkel cell carcinoma SAN GALLICANO Oncology 2 17 573.100 2309103 Hepatitis C virus (HCV) infection beyond the liver: bone and cardiovascular manifestations. Sicilia Musculoskeletal, Oral and Skin Sciences 17 250.000 2310814 Cystic Lesions of the Pancreas: Creation of a Database and a New Evidence Based, Cost Effective Algorithm Sicilia Oncology 2 17 302.500 Pagina 110 di 142

2318578 Effectiveness of cognitive remediation in schizophrenia: a prospective, multicenter study in the "real world" setting of Italian psychiatric services Lombardia Brain Disorders and 17 500.000 2313996 Protective ventilatory strategy in severe brain injured patients: a randomized control trial Piemonte Cardiovascular and 17 150.000 2315308 The SHARP Study: Simultaneous Hybrid Revascularization by Carotid Stenting and Coronary Artery Bypass Grafting Lazio Surgical Sciences, Biomedical Imaging, and Bioengineering 17 0 2318531 A NEW CARE MODEL TO MAINTAIN FUNCTION IN STROKE PATIENTS:EARLY THERAPEUTIC PATIENT EDUCATION AND LONG TERM GROUP PHYSICAL ACTIVITY(e TEAM2011 : early Therapeutic Education Associated with Movement) ARCISPEDALE Risk, Prevention and Health Behavior 17 150.000 2314927 Use and integration of clinical and administrative databanks to evaluate the quality and continuity of care processes for epidemiological study and for health planning for patients affected by heart brain vascular diseases. Lombardia Healthcare Delivery and 17 480.000 2318704 Development and validation of a simple and wearable new system for monitoring sleep and respiratory variables Toscana Bioengineering Sciences and Technologies 17 220.000 2305722 Post genomic approach to heart failure in diabetic patients SAN DONATO Cardiovascular and 17 580.000 2317431 The pathophysiological substrates of myoclonic syndromes: implementation of innovative multimodal functional approach and treatments CARLO BESTA Brain Disorders and 17 548.000 2301927 From diet to cancer: an integrated approach to study the complex path from visceral fat associated inflammation to colon cancer Istituto Superiore di Sanita' Immunology 17 550.000 2312673 Mechanisms of beneficial effects of physical exercise on healthy aging and neurological age related diseases MAUGERI Biology of Development and Aging 17 400.000 Pagina 111 di 142

2321481 Evaluation of Diagnostic Accuracy of DW and DCE Magnetic Resonance Imaging in the Mesorectal Nodes staging of Rectal Carcinoma ISTITUTO TUMORI MILANO Surgical Sciences, Biomedical Imaging, and Bioengineering 17 200.000 2319660 The impact of depressive disorders on endothelial progenitor cells in patients with ischemic heart disease Toscana Cardiovascular and 17 300.000 2317262 Frameless localisation technique for brain stereotactic radiotherapy Toscana Oncology 2 17 170.000 2317006 The BRCAness profile: from the molecular basis to the clinical relevance Toscana Oncology 1 Basic 17 300.000 2308025 GENERATION OF HUMAN MONOCLONAL ANTIBODIES INTERFERING WITH HIV TRANSCYTOSIS FOR THE PREVENTION OF MUCOSAL INFECTION Istituto Superiore di Sanita' AIDS and Related Research 17 562.000 2313999 Biological foundations of self control and potential diagnostic implications Istituto Superiore di Sanita' Biobehavioral and Behavioral Processes 17 361.000 2316421 HIV 1 Nef protein affects opportunistic infections in human macrophages Istituto Superiore di Sanita' AIDS and Related Research 17 333.333 2302685 Glycation/glycoxidation products in the pathogenesis of cardiovascular diseases: a search for new biomarkers of cardiovascular risk Istituto Superiore di Sanita' Cardiovascular and 17 583.000 2304431 The Italian National Program on Surveillance of Antiretroviral Treatment in Pregnancy Istituto Superiore di Sanita' AIDS and Related Research 17 567.000 2315225 BREAST CANCER RISK AND DIETARY MICRONUTRIENTS ASSOCIATED WITH ONE CARBON METABOLISM PATHWAY IN BRCA1/2 SUBJECTS: AN OBSERVATIONAL STUDY C.R.O. AVIANO Population Sciences and Epidemiology 17,25 180.400 2313357 MULTI CENTER STUDY ON METABOLIC COMPLICATIONS IN HIV INFECTED PEDIATRIC PATIENTS Lombardia AIDS and Related Research 17,25 100.000 Pagina 112 di 142

2314084 Healthy diet: evaluation of antioxidant capacity of a weekly selected menu in elderly people, and factors affecting its strength. Emilia Romagna Healthcare Delivery and 17,5 418.500 2314178 REGISTRY FOR HEREDITARY AND FAMILIAL BREAST CANCER AND IDENTIFICATION OF NEW DISEASE CAUSING GENES AND REGIONS Lombardia Oncology 2 17,5 198.000 2308464 Leukocyte telomere length and risk of ischemic vascular disease in an Italian population. Molise Genes, Genomes and Genetics 17,5 585.400 2309249 STUDY OF DIAGNOSTIC AND THERAPEUTIC INTERVENTIONS FOR ALLERGIC DISEASES IN LOMBARDY BY COST UTILITY ANALYSIS Healthcare Delivery and 17,5 400.000 2309927 The effectiveness of Individual Placement and Support (IPS) in clients with first episode of psychosis. Emilia Romagna Healthcare Delivery and 17,5 200.000 2317165 High field MR evaluation in low level consciousness patients NEUROLESI Brain Disorders and 17,5 225.000 2315967 ROLE OF ENPP1 AND HSP70 SERUM LEVELS ON CARDIOVASCULAR DISEASE IN PATIENTS WITH TYPE 2 DIABETES MELLITUS CASA SOLLIEVO SOFFERENZA Vascular and Hematology 17,5 330.000 2318029 Fibrin resistance to lysis in pulmonary hypertension Toscana Cardiovascular and 17,5 431.500 2308105 RNA sequencing for the detection of progressive HPV lesions REGINA ELENA Oncology 2 17,5 592.000 2319888 Study of three dimensional model analysis for evaluation of pelvic volume in patients with hemodynamic instability due to pelvic fracture. Emilia Romagna Surgical Sciences, Biomedical Imaging, and Bioengineering 17,5 500.000 2321536 Identification of prevalence of urinary incontinence in breast cancer women in hormonal treatment. Identification of a diagnostic and therapeutic path. Toscana Healthcare Delivery and 17,5 300.000 2310442 Andrological Screening and Reproductive Health in Young Adult Males Veneto Population Sciences and Epidemiology 17,5 300.000 Pagina 113 di 142

2308339 Molecular mechanisms, animal models and preclinical studies for validation of innovative target for pharmacological therapy of Huntington disease Istituto Superiore di Sanita' Brain Disorders and 17,67 560.000 2312857 The effects of different rehabilitation treatments on left unilateral neglect S.CAMILLO Risk, Prevention and Health Behavior 17,75 230.000 2311636 Gene expression profile and epigenetic regulation in human white adipose tissue AUXOLOGICO Endocrinology, Metabolism, Nutrition and Reproductive Sciences 17,75 434.500 2321764 Novel POCT device for sepsis diagnosis based on a multiassay optical biochip Toscana Bioengineering Sciences and Technologies 18 500.000 2316115 Hypertension in children adolescents:predictors,risk factors and intra uterine growth retard Toscana Healthcare Delivery and 18 158.000 2319202 Effectiveness and cost effectiveness of eating disorder networks in Italy Emilia Romagna Biobehavioral and Behavioral Processes 18 400.000 2309188 QUANTEC:QUantitative Analysis of Normal Tissue Effects in the Clinic.A Multicenter Italian prospective contribute to international research on radiation therapy damage,through a correlation between clinic,imaging,dosimetry and biology. Lombardia Oncology 2 18 246.000 2319352 Association of all trans retinoic acid (ATRA) and trastuzumab for HER 2 positive metastatic breast cancer: a phase II evaluation of ATRA potential immunomodulatory activity for myeloid derived suppressor cells (MDSC). I. O. V. Oncology 2 18 298.000 2319304 Reducing the costs associated to post stroke rehabilitation: a novel robot assisted treatment protocol Veneto Emerging Technologies and Training in s 18 500.000 2321778 Proteomics and transcriptomics studies to define a new role of REP1: insights in the molecular pathogenesis of Choroideremia SDN Cell Biology 18 400.000 Pagina 114 di 142

2318479 Emerging technologies for genome manipulation, detection and characterization of West Nile virus strains Istituto Zooprofilattico Sperimentale dell'abruzzo e del Molise Veterinary 18 570.000 2318591 IMPROVEMENT OF BREAST CANCER THERAPY BY USING NANOVECTOR DELIVERY SYSTEMS Istituto Superiore di Sanita' Oncology 2 18 585.000 2321118 Genotoxic effects related to pesticide exposure: a novel bio monitoring approach IRCCS AOU San Martino IST (Genova) Population Sciences and Epidemiology 18 400.000 2317404 Identification of new heart related mirnas as tools for diagnosis and terapy of heart malformations and diseases Emilia Romagna Cardiovascular and 18 450.000 2316355 Continuity of CAre for severe chronic REspiratory patients (CARE) Puglia Healthcare Delivery and 18 600.000 2303971 Human Mesenchymal Stem Cells as site regulated medicinal cells stimulating endogenous repair mechanisms in tissue injury IRCCS AOU San Martino IST (Genova) Musculoskeletal, Oral and Skin Sciences 18 600.000 2314971 Neuroplasticity, rehabilitation and work ability Ist. Sup. per la Prevenzione e Sicurezza sul Lavoro Brain Disorders and 18 595.000 2319436 Human Autologous Cardiospheres For The Treatment Of Paediatric Heart Failure OSPEDALE BAMBINO GESU' Cardiovascular and 18 600.000 2318346 CORRELATIONS OF THE NICO NEUROPHYSIOLOGICAL FEATURES WITH THE HISTOPATHOLOGICAL FINDINGS AND microrna EXPRESSION IN DRUG RESISTANT TEMPORAL LOBE EPILEPSY Istituto Scienze Neurologiche Brain Disorders and 18 250.000 2315317 Mesenchymal stem cells and T cells in head and neck squamous cell carcinoma: a unified vision of the tumoral stroma for the identification of new prognostic markers and possible therapeutical targets. Toscana Immunology 18 440.000 Pagina 115 di 142

2315337 Functional modifications of Substantia nigra pars reticulata neurons firing upon high frequency stimulation in the Subthalamic nucleus: a parallel investigation on Parkinson s disease patients treated with Deep Brain Stimulation and on rat midbrain slice SANTA LUCIA Brain Disorders and 18 400.000 2309980 Biomarkers of clinical outcomes in stroke patients. Role of Alfa Melanocortin and Brain Derived Neurotrophic Factor polimorfisms in neurorehabilitation. S.CAMILLO Brain Disorders and 18 210.000 2320953 Cytokine profile in ocular surface diseases and upper airways disorders: development of medical devices for ophthalmology and otorhinolaryngology use. Sicilia Interdisciplinary Molecular Sciences and Training 18 390.000 2303445 Coronary arteriogenesis with combined pharmacological (dipyridamole and heparin) therapy Toscana Cardiovascular and 18 417.500 2317703 Primary prevention of Neural Tube Defects (NTD) by Inositol: the ASBI case control study Liguria Risk, Prevention and Health Behavior 18 353.160 2313823 Effects of early microbiological diagnosis (molecular tests vs standard) on length of stay in Intensive Care Unit Emilia Romagna Infectious Diseases and Microbiology 18 312.705 2315786 Adenosine receptor imaging and function, and therapeutic targets in Chronic Heart Failure Toscana Cardiovascular and 18 215.000 2307294 Cranioplasty and rehabilitation for brain injured patients Emilia Romagna Brain Disorders and 18 250.000 2316128 CORRELATION BETWEEN BREST ARTERIAL CALCIFICATIONS AT MAMMOGRAPHY AND CORONARY ARTERY CALCIUM SCORE IN ASYMPTOMATIC DIABETIC PATIENTS: TWO SCREENING IN ONE SAN DONATO Cardiovascular and 18 200.000 2318829 New nanotools for permeabilization of Brain Blood Barrier and early detection of Alzheimer disease NEUROMED Emerging Technologies and Training in s 18 600.000 2315183 Randomized controlled trial on the role of telemonitoring for the management of chronic obstructive pulmonary disease (COPD) Sicilia Cardiovascular and 18 214.250 Pagina 116 di 142

2312271 CORONARY ATHEROSCLEROSIS IN THE YOUNG: EARLY DIAGNOSIS AND IDENTIFICATION OF RISK FACTORS FOR SUDDEN DEATH PREVENTION Veneto Cardiovascular and 18 290.000 2308627 Effects of ALR administration, a physiological antiapoptotic and anti oxidative molecule, on Parkinson's Disease transgenic mice during the progression of the disease. DE BELLIS Brain Disorders and 18 150.000 2313600 Next Generation Sequencing approaches for Diagnostics of common and rare genetic diseases NEUROMED Genes, Genomes and Genetics 18 300.000 2313068 microrna deregulation in atrial fibrillation: identification of pathogenetic mechanisms and of peripheral blood biomarkers SAN DONATO Cardiovascular and 18 400.000 2308398 Deployment of the trigger tools within the electronic medical record to enhance error detection in Neonatal Intensive Care Units (NICU): a cluster, randomized trial Lombardia Healthcare Delivery and 18 525.000 2319383 Four dimensions augmented reality navigation system for medical interventions CASA SOLLIEVO SOFFERENZA Surgical Sciences, Biomedical Imaging, and Bioengineering 18 600.000 2320254 Identification of novel functional and biological parameters to predict the response to cardiac resynchronization therapy SAN MATTEO Cardiovascular and 18 486.000 2312509 Surgical aortic valve replacement versus transcatheter aortic valve implantation in patients 80 years and older at low surgical risk:the ELDERLY VALVE Trial Cardiovascular and 18 600.000 2312674 Study of the role of immune activation and immune senescence in the pathogenesis of atherosclerosis and bone metabolism disorders in HIV infected patients undergoing highly active antiretroviral therapy (HAART) Lombardia AIDS and Related Research 18 135.420 2320257 Investigation of link between Lung Cancer Stem Cells (CSCs) and Epithelial Mesenchymal Transition (EMT) for tumour progression and metastatis PASCALE Oncology 1 Basic 18,25 200.000 Pagina 117 di 142

2310547 Cognitive rehabilitation after stroke: a randomized controlled trial to compare the efficacy of different protocols. Sicilia Brain Disorders and 18,25 150.000 2317440 Predictive models of genito urinary and sexual dysfunction after high dose radiotherapy for prostate cancer ISTITUTO TUMORI MILANO Oncology 2 18,25 399.300 2312337 THE RELATIONSHIP BETWEEN BORDERLINE PERSONALITY DISORDER AND BIPOLAR DISORDER: A NICAL, MORPHOLOGIAL CEREBRAL AND LOGICAL COMPARISON STUDY FATEBENEFRATELLI Brain Disorders and 18,25 600.000 2321750 IDENTIFICATION OF GENETIC RISK FOR MELANOMA AND CANCERS OTHER THAN MELANOMA IN RELATIVES OF PATIENTS WITH CUTANEOUS MELANOMA SAN MATTEO Oncology 1 Basic 18,5 450.000 2315247 Biomarkers for optimization of Attention Deficit Hyperactivity Disorder (ADHD) pharmacological therapy FATEBENEFRATELLI Biobehavioral and Behavioral Processes 18,5 600.000 2311593 2311651 Optimising Natural Killer (NK) cell activation for liver anti fibrogenic immunotherapy. Epstein Barr virus infection and risk of developing autoimmune disease SAN MATTEO Immunology 18,5 400.000 Istituto Superiore di Sanita' Immunology 18,5 450.000 2311336 Deciphering the Transcriptional Signature of Sporadic Brain Arteriovenous Malformations: a Genome Wide Expression Study Istituto Superiore di Sanita' Brain Disorders and 18,5 600.000 2316246 DESIGN OF NOVEL RATIONAL THERAPEUTIC STRATEGIES FOR RET DRIVEN MEDULLARY THYROID CARCINOMA ISTITUTO TUMORI MILANO Oncology 1 Basic 18,5 567.600 2306917 Congenital malformations in domestic ruminant calves in southern Italy: a study of the main genetic, toxicological and infective causes Istituto Zooprofilattico Sperimentale del Mezzogiorno Veterinary 18,5 600.000 Pagina 118 di 142

2306703 Metabolic and cardiovascular risk in non obese and obese patients with obstructive sleep apnea: long term follow up Sicilia Population Sciences and Epidemiology 18,5 231.500 2318517 2312335 ANTIOXIDANT PROTECTION IN HIV RELATED NEURODEGENERATIVE DISORDERS Improving accuracy in cardiovascular disease risk prediction by metabolic markers in the Italian population Calabria AIDS and Related Research 18,5 450.000 Lombardia Vascular and Hematology 18,5 270.000 2305600 Role of hypoxia in glioblastoma metabolism. Looking for new therapeutic strategies to counteract tumor progression and recurrencies Abruzzo Oncology 1 Basic 18,5 200.000 2309779 OBESITY AND MALE HYPOGONADISM: WHO COMES FIRST? SAN DONATO Endocrinology, Metabolism, Nutrition and Reproductive Sciences 18,5 75.000 2316973 BEVO SIRCOPANOS (endocrine Benefits from Sicilian Extra Virgin Olive Oil, Sicilian Red wine and Consumption of Pesce Azzurro but No Smoking): a project by The Program of Molecular & Endocrinology and Women s Endocrine Health. Sicilia Endocrinology, Metabolism, Nutrition and Reproductive Sciences 18,5 350.000 2304418 Identification and biological characterization of individuals at risk for hereditary colorectal tumors Emilia Romagna Genes, Genomes and Genetics 18,5 180.000 2309654 A study to identify and validate predictive biomarkers for clinical outcome after oxaliplatin based adjuvant chemotherapy (CT) in early stage colorectal cancer (ecrc) and bevacizumab based CT in metastatic colorectal cancer (mcrc) HUMANITAS Oncology 2 18,5 478.100 2314895 THE ROLE OF EARLY SCREENING IN PERINATAL DEPRESSION Toscana Risk, Prevention and Health Behavior 18,5 185.760 2314554 Prediction of response to targeted therapies in esophageal adenocarcinoma patients using an endoscopic biopsies xenograft rat model. I. O. V. Oncology 2 18,5 250.000 Pagina 119 di 142

2318061 A MULTIMODALITY APPROACH TO PREVENT THE NEUROLOGICAL DYSFUNCTION IN CARDIAC SURGERY Veneto Brain Disorders and 18,5 370.600 2319630 Strategies of psychological support in the context of clinical medical treatments aimed at preserving fertility in oncology, for women of childbearing age and girls of prepubertal age candidate for ovarian tissue banking. REGINA ELENA Risk, Prevention and Health Behavior 18,5 300.000 2303174 Natural Chemistry and Physical Energy to Optimize Stem Cell Therapy of Vascular Diseases Emilia Romagna Vascular and Hematology 18,75 600.000 2316793 Does adolescents perception of parental and peer drinking habits and lifestyle affect their approach to alcohol consumption? Molise Healthcare Delivery and 18,75 383.000 2319786 Emerging and Re emerging Viral Infections in the Tuscany Region Toscana Infectious Diseases and Microbiology 18,83 400.000 2299888 Assessment of the role of image guided hypofractionated intensity modulated radiotherapy in the treatment of low and intermediate risk prostate cancer Emilia Romagna Oncology 2 19 400.000 2300607 Mediterranean Dietary to prevent conversion of Mild Cognitive Impairment to Alzheimer Disease: a randomized trial. CARLO BESTA Brain Disorders and 19 600.000 2317260 HOSPITAL PROCEDURES FOR ACUTE HEART FAILURE AND INTEGRATED COUNTRY/HOSPITAL CARE Sicilia Cardiovascular and 19 150.000 2302678 Host/Tumor Tailored Clock Chemotherapy: fighting cancer around the clock CASA SOLLIEVO SOFFERENZA Oncology 1 Basic 19 350.000 2311897 AEQUITAS: Inequality and Quality of regional clinical pathways in diabetes management Marche Population Sciences and Epidemiology 19 200.000 2310156 Impact of tobacco control policies and implementation of tobacco control interventions Toscana Risk, Prevention and Health Behavior 19 350.000 Pagina 120 di 142

2317762 Development of a Preclinical Model of Peritoneal Carcinomatosis with Cells from patients with Human Gastric Cancer Oncology 1 Basic 19 550.000 2299093 Genetic response of colorectal carcinoma to chemotherapy to predict tumor response and circumvent chemoresistance Veneto Oncology 2 19 240.000 2313797 Cheyne Stokes respiration in heart failure patients: from the identification of individual pathophysiological mechanisms to individualized treatment MAUGERI Cardiovascular and 19 318.000 2313841 Metformin plus standard chemotherapy: a new weapon to target tumor initiating cells in colorectal cancer treatment and prevention ISTITUTO TUMORI MILANO Oncology 2 19 433.000 2302629 The personalized antidepressant therapy: from the genetic to clinical impact Provincia autonoma Bolzano Emerging Technologies and Training in s 19 450.000 2304870 A stem cell platform to identify adverse effects of toxicants: an integrated environmental analysis (food, air and water) MAUGERI Cardiovascular and 19 500.000 2306456 Next Generation Sequencing techniques open up new possibilities in the knowledge and diagnosis of hereditary arrhythmogenic diseases Piemonte Cardiovascular and 19 512.000 2320575 and prognostic evaluation of thoracic aortic aneurysms: integration between MRI indexes, biological and biomechanical properties Toscana Cardiovascular and 19 550.000 2315259 Autophagy inhibition in chronic myelogenous leukemia stem cells: the way to the cure? IRCCS AOU San Martino IST (Genova) Vascular and Hematology 19 405.000 2320937 Development of predictive models based on clinical indicators, dosimetry and bioimaging to describe the dose effect due to laser treatment of skin cancer lesions SAN GALLICANO Oncology 2 19 600.000 2312892 Genetic determinants of heart failure (HF) Friuli Venezia Giulia Cardiovascular and 19 400.000 Pagina 121 di 142

2315052 EXPERIMENTAL MODELLING OF TUMOR RELAPSE FOR THE DESIGN AND PRE NICAL VALIDATION OF COMBINATORIAL APPROACHES OF TARGETED THERAPY IN ORAL CAVITY CARCINOMAS Emilia Romagna Oncology 2 19 490.000 2316114 Identification of metabolic and immunological parameters predictive for the risk of diseases or fertility problems in periparturient dairy cows Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche Veterinary 19 450.000 2318625 The early identification of the free radical disease of the newborn. New therapeutic strategies. Toscana Healthcare Delivery and 19 298.500 2306800 Technological advancement in deep brain stimulation surgery for Parkinsonian patients: use of neuronavigated frameless system Sicilia Brain Disorders and 19 200.000 2314390 IGF PATHWAY IN NEUROENDOCRINE TUMORS: PROGNOSTIC ROLE AND NOVEL TARGET THERAPY SDN Endocrinology, Metabolism, Nutrition and Reproductive Sciences 19 400.000 2313342 THE IMPACT OF EPIGENOMICS ON THE IDENTIFICATION OF NEW PROGNOSTIC MARKERS AND INNOVATIVE THERAPIES IN NEUROENDOCRINE TUMORS (NETs) AUXOLOGICO Oncology 1 Basic 19 450.000 2311578 Prevalence and risk factors of genital Chlamydia trachomatis infection among sexually active young women (15 24 years), in Italy Istituto Superiore di Sanita' Population Sciences and Epidemiology 19,5 510.000 2315255 Development of a DNA microarray for a rapid and reliable detection of pathogens in ready to eat foods. Istituto Zooprofilattico Sperimentale del Mezzogiorno Veterinary 19,5 500.000 2319919 Prevention of chronic kidney disease (CKD) progression by hypoxia inducible prolyl hydroxylases (HIF PHs) inhibition: role of SIRT1 and autophagy MAUGERI Digestive, Kidney and Urological Systems 19,5 250.000 2314612 Defective DNA polymerase beta isoforms as protective factors against Alzheimer's disease OASI MARIA S.S. Biology of Development and Aging 19,5 300.000 Pagina 122 di 142

2314016 2311474 2304279 2303758 Transgenic zebrafish model to visualize proliferation in vivo. PEPTIDE FROM PARIETARIA JUDAICA POLLEN WITH ANTI MICROBIAL ACTIVITY AS A NEW THERAPEUTICAL TOOL: EVALUATION OF INTERACTION WITH THE IMMUNE SYSTEM PRE NICAL DEVELOPMENT OF A HUMAN MONOCLONAL ANTIBODY AGAINST FAS LIGAND FOR THE TREATMENT OF PEMPHIGUS Evaluation of the therapeutic role of mesenchimal stromal cells in a murine model of systemic lupus erythematosus. REGINA ELENA Cell Biology 19,5 230.000 Istituto Superiore di Sanita' Immunology 19,5 357.000 Emilia Romagna Immunology 19,5 600.000 Toscana Immunology 19,5 240.000 2307927 Enhancement of NKG2D ligands induced anti tumor response in Hodgkin s lymphomas: ERp5 thiol isomerase and ADAM10 disintegrin metalloproteinase as possible therapeutic targets. Immunology 19,5 221.000 2305989 Sudden sensorineural hearing loss: searching for new molecular markers. Emilia Romagna Vascular and Hematology 19,5 150.000 2321765 Microvesicles as mediators of cell to cell interaction in hematological malignancies: biological characterization and clinical relevance in Chronic Lymphocytic Leukemia and Myelodysplastic Syndrome Piemonte Oncology 2 19,5 500.000 2312005 NCRpos Vd1 T cells: role of a newly disclosed gammadelta T cell subset in eradicatingtumors, in suppressing HIV 1 replication and in modulating the homeostasis of gut mucosalimmunity. HUMANITAS Immunology 19,5 592.000 2319645 HEART KIDNEY INTERACTIONS IN CHRONIC AND ACUTE DECOMPENSATED HEART FAILURE Emilia Romagna Cardiovascular and 19,5 277.776 2301188 RNA silencing of the Gene for the Augmenter of Liver Regeneration in Hepatocarcinogenesis in vivo. DE BELLIS Oncology 1 Basic 19,5 150.000 Pagina 123 di 142

2319803 DIGITAL KIDS Emilia Romagna Healthcare Delivery and 19,5 300.000 2319520 A longitudinal study to evaluate personality and mood disorders in patients with Multiple sclerosis SANTA LUCIA Brain Disorders and 19,5 120.000 2310757 PCA3,ADVANCED MAGNETIC RESONANCE IMAGING TECHNIQUES AND TISSUE AND CIRCULATING MOLECULAR MARKERS IN PROSTATE CANCER: DEFINING A NOVEL DIAGNOSTIC AND PROGNOSTIC ALGORITHM PASCALE Oncology 2 19,5 300.000 2321061 Old and new hypoglycemic agents and incidence of cancer in a large cohort of type 2 diabetic patients: the RIACE Study Toscana Risk, Prevention and Health Behavior 20 150.000 2313556 Physical activity as a strategic measure to reduce drugs consumption and interactions in elderly patients with cardiovascular disease and comorbidity Molise Healthcare Delivery and 20 580.000 2316165 COCAINE CHEST PAIN Emilia Romagna Risk, Prevention and Health Behavior 20 160.000 2312860 INSTITUTION OF A REGIONAL MULTIDISCIPLINARY NETWORK FOR FERTILITY PRESERVATION IN CANCER SURVIVORS. CREATION AND IMPLEMENTATION OF AN INNOVATIVE ORGANIZATIONAL MODEL ISTITUTO TUMORI MILANO Endocrinology, Metabolism, Nutrition and Reproductive Sciences 20 451.000 2311705 Perioperative markers of neurological and lung damage in infants with congenital heart diseases (CHD). A three years follow up study. OSPEDALE BAMBINO GESU' Cardiovascular and 20 400.000 2312397 EARLY START EXERCISE TRAINING AFTER ACUTE DECOMPENSATION IN PATIENTS WITH CHRONIC HEART FAILURE: FEASIBILITY AND IMPACT ON FUNCTIONAL CAPACITY, NEUROHUMORAL ACTIVATION AND QUALITY OF LIFE. MAUGERI Cardiovascular and 20 350.000 2312515 Analysis of immunogenicity of putative GPI anchored proteins of Babesia for vaccine and diagnostic purposes Istituto Zooprofilattico Sperimentale della Sicilia Veterinary 20 320.000 Pagina 124 di 142

2322018 Analysis of epidemiology and molecular characteristics of emerging salmonella serovars in Italy Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia Veterinary 20 500.400 2308380 effect of different therapeutic approaches for thyroidrelated orbitopathy (Graves' orbitopathy) Lazio Endocrinology, Metabolism, Nutrition and Reproductive Sciences 20 0 2309310 Overcoming chemoresistance in adrenocortical cancer Emilia Romagna Oncology 2 20 300.000 2318413 Facing dourine challenge: improvement of diagnostic tools and investigation of pathogenic mechanisms Istituto Zooprofilattico Sperimentale dell'abruzzo e del Molise Veterinary 20 570.000 2309542 Modulation of the NAD salvage pathway as a novel pharmacological approach for spinal cord injury: a latepreclinical study NEUROLESI Brain Disorders and 20 545.600 2304622 PARP 1 and PARP 2 may have a differential role in supporting tumor cell growth: studies on the effects of selective subtype inhibitors in cell lines and in vivo. Toscana Oncology 2 20 332.000 2318980 GABAergic modulation of resting state and stimulusinduced activity within the default mode network: a translational investigation on depression. SANTA LUCIA Brain Disorders and 20 600.000 2316036 Bergamot Polyphenol Fraction as a treatment for metabolic syndrome and related cardiovascular complications: focus on mechanisms and bases of in vivo efficacy SAN RAFFAELE PISANA Endocrinology, Metabolism, Nutrition and Reproductive Sciences 20 360.000 2316372 ROLE AND IMPACT OF DNA VIRUSES IN AUTOIMMUNE DISEASES Emilia Romagna Infectious Diseases and Microbiology 20 387.778 2307214 Eco epidemiology of M. bovis in a complex rural zoothenic system and identification of wild animals reservoirs Istituto Zooprofilattico Sperimentale della Sicilia Veterinary 20 600.000 Pagina 125 di 142

2319900 PHENOTYPE GENOTYPE CORRELATION IN PATIENTS AFFECTED BY HYPOGONADISM: IMPLICATIONS FOR NICAL MANAGEMENT. Toscana Endocrinology, Metabolism, Nutrition and Reproductive Sciences 20 200.000 2317695 PROTEASE VARIABILITY IN PATIENTS INFECTED WITH HEPATITIS C VIRUS GENOTYPE 1: IMPLICATION FOR ANTIVIRAL TREATMENT USING DIRECTLY ACTING ANTIVIRALS (DAA) Sicilia Infectious Diseases and Microbiology 20 410.000 2313598 Differentiating Ehrlich carcinoma cells and reducing ascites in rats in vivo. A preclinical study. Ist. Sup. per la Prevenzione e Sicurezza sul Lavoro Oncology 1 Basic 20 600.000 2320022 Action and object observation treatment in acute stroke patients NEUROMED Brain Disorders and 20 210.000 2315455 Role of autophagy in the control of regulatory T cells and autoimmunity SANTA LUCIA Immunology 20 600.000 2308215 Determinants of FDG uptake in Hodgkin disease IRCCS AOU San Martino IST (Genova) Bioengineering Sciences and Technologies 20 155.000 2314407 TESTING A MODEL FOR THE ASSESSMENT OF APPROPRIATENESS OF THE USE OF DRUGS, WITH ACTIONS TO SUPPORT HEALTH AND SOCIAL CARE TO FRAIL ELDERLY PEOPLE IN THE HOME VIA HOME DELIVERY OF THERAPY AND CONSEQUENT REDUCTION IN PHARMACEUTICAL EXPENDITURE WITHIN THE NA Marche Healthcare Delivery and 20 200.000 2314897 Vaccination strategies to prevent infections in splenectomized patients SAN MATTEO Immunology 20 200.000 2320770 Myocardial Fibrosis in Valvular Heart Disease Lazio Cardiovascular and 20 595.500 2318867 Multimodal approach to the presurgical evaluation of drug resistant epilepsy S.CAMILLO Brain Disorders and 20 280.000 Pagina 126 di 142

2319591 Effect of intensive control of glycemia and associated cardiovascular ( CV ) risk factors on the evolution of severe psychiatric disorders. Emilia Romagna Endocrinology, Metabolism, Nutrition and Reproductive Sciences 20 170.000 2320563 The unawareness of illness and executive dysfunctions in bipolaroutpatients Piemonte Brain Disorders and 20 160.500 2322075 Benefits of cognitive training in healthy older adults after identification of risk factors for neurodegeneration MAGGIORE Biology of Development and Aging 20 210.000 2314339 Effects of robotic aided rehabilitation on the wrist joint in hemiparetic patients: an fmri study Istituto Superiore di Sanita' Musculoskeletal, Oral and Skin Sciences 20 573.100 2319625 Neurodegenerative disorders and tumors: epidemiologic and genetic investigation on their relationship. Sicilia Population Sciences and Epidemiology 20 300.000 2312124 Identification of new gender associated biomarkers in metabolic syndrome Istituto Superiore di Sanita' Cardiovascular and 20 400.000 2319519 Role of chest physical examination to identifiy patients with early idiopathic pulmonary fibrosis: a multicenter prospective study Emilia Romagna Cardiovascular and 20 108.000 2315036 Study on transmission patterns of Salmonella enterica serovar 4, 5, 12:i: within pig units Istituto Zooprofilattico Sperimentale dell'umbria e delle Marche Veterinary 20 200.000 2317358 Identification of molecular biomarkers to improve the preoperative diagnosis of follicular type thyroid cancer in the TIR3 cytologic stage as determined by classic FNA cytology Emilia Romagna Oncology 2 20 400.000 2320025 Multidisciplinary Network for Chronic Pain Prevention. Interregional Model SAN MATTEO Healthcare Delivery and 20 250.000 2302783 Pharmacogenetics in Psychiatry: genetic susceptibility to psychotropic drugs metabolism CASA SOLLIEVO SOFFERENZA Brain Disorders and 20,25 200.050 Pagina 127 di 142

2316430 Immunomodulatory effects of umbilical cord Wharton jelly derived human adult mesenchymal stem cells (hucms) on circulating Tc subsets of patients with systemic autoimmune disorders such as: 1) Type 1 diabetes mellitus (T1DM); 2) Connective tissue diseases Umbria Immunology 20,5 350.000 2321040 Beneficial impact of Caribbean dances and Mediterranean diet on patients with cardiovascular risk Puglia Cardiovascular and 20,5 250.000 2309240 High risk preterm infants: an early diagnostic therapeutic intervention Piemonte Biobehavioral and Behavioral Processes 20,5 126.000 2318889 Accuracy and clinical impact of 68 Ga labeled octreotide analogues PET in diagnosis and staging of duodenopancreatic neuroendocrine tumours; proposal of a multicenter, prospective, non randomized clinical trial. ARCISPEDALE Surgical Sciences, Biomedical Imaging, and Bioengineering 20,5 284.104 2308465 Evaluation of tolerability and efficacy of sorafenib treatment in patients with hepatocellular carcinoma. Sicilia Oncology 2 20,5 157.000 2310118 ENVIROMENTAL ENRICHMENT AS A TREATMENT OF OBESITY IN CHILDREN AND ADOLESCENTS WITH INTELLECTUAL DISABILITY STELLA MARIS Brain Disorders and 20,5 180.000 2310870 Cardiotoxicity from antracyclines and trastuzumab in the adjuvant treatment of breast cancer: early identification of high risk patients with a panel of biomarkers compared to traditional ecocardiographic evaluation. I. O. V. Oncology 2 20,5 360.000 2311781 Integration of an inpatient clinical research in medical oncology within an intensity of care focused hospital (ICFH) model Liguria Healthcare Delivery and 20,5 380.500 2301976 Genetic and malformation risk associated with techniques of fertilization in vitro (IVF): a comparative prospective study of genetic and ultrasound analyses of fetuses conceived with IVF and spontaneously. BURLO GAROFALO Endocrinology, Metabolism, Nutrition and Reproductive Sciences 20,5 265.000 2311170 Environmental and biological monitoring of exposure to traffic related air pollution for outdoor workers and evaluation of genotoxic and cardiovascular effects Ist. Sup. per la Prevenzione e Sicurezza sul Lavoro Population Sciences and Epidemiology 20,5 500.000 Pagina 128 di 142

2306008 2310404 INNATE IMMUNE CELL RESPONSE TO HYPOXIC MICROENVIRONMENT: IDENTIFICATION OF POTENTIAL THERAPEUTIC TARGETS FOR JUVENILE IDIOPATHIC ARTHRITIS Obesity as an intermediate phenotype of cardiovascular disease and cancer: in vivo and in vitro studies on tissue factor expression and related processes GASLINI Immunology 20,5 305.000 Molise Vascular and Hematology 20,5 520.080 2320455 Transient Receptor Potential Canonical 1 (TRPC1) in pancreatic cancer: a new actor for NF kb inactivation CASA SOLLIEVO SOFFERENZA Oncology 2 20,5 190.000 2317474 New frontiers in breast imaging: contrast enhanced digital mammography. performance of contrastenhanced spectral mammography (CESM SenoBright) in pre surgical evaluation of extent of malignancy in a population of women with breast cancer. I.E.O. Oncology 2 20,75 390.000 2314871 BCL XL GENE EXPRESSION QUANTIFICATION FOR MINIMAL RESIDUAL DISEASE DETECTION IN PMF: A NEW MOLECULAR MARKER TO PREDICT EARLY RELAPSE IN JAK2V617F NEGATIVE PATIENTS. IRCCS AOU San Martino IST (Genova) Oncology 2 20,75 225.000 2320352 MOLECULAR CHARACTERIZATION OF BLASTIC PLASMACYTOID DENDRITIC CELL NEOPLASM MAGGIORE Genes, Genomes and Genetics 21 400.000 2303051 Path to cure CML and Ph+ leukemias Emilia Romagna Oncology 2 21 150.000 2321691 Development, Implementation and Evaluation of a Complex Program Focused on Quality of Life Assessment in the Palliative Care Network of the Ligurian Region IRCCS AOU San Martino IST (Genova) Healthcare Delivery and 21 300.000 2315648 2318324 Generic substitution of antidepressant drugs NEUROLESI Brain Disorders and Vitamin D supplements in geriatric major depression Emilia Romagna Brain Disorders and 21 180.000 21 340.000 2303143 Identification of a multi SNP profiling to predict metabolic syndrome in children OSPEDALE BAMBINO GESU' Genes, Genomes and Genetics 21 225.000 Pagina 129 di 142

2318553 Epigenetic alterations in nicotine and alcohol dependence Emilia Romagna Brain Disorders and 21 440.000 2320318 ROLE OF GENE POLYMORPHISMS IN PREDICTING EFFICACY AND TOXICITY IN DIFFUSE LARGE B CELL LYMPHOMA PATIENTS TREATED WITH R CHOP IMMUNOCHEMOTHERAPY Toscana Oncology 2 21 392.150 2321917 Purification and utilization of adult adipose derived mesenchymal stem cells (ADMSC) from rat adipose tissue and their transdifferentation toward endothelial cells for kidney function recovery Istituto Zooprofilattico Sperimentale della Sicilia Digestive, Kidney and Urological Systems 21 150.000 2319318 Sonochemotherapy. A new combined approach of sonoporation plus chemotherapy for the treatment of poorly chemosensitive cancers. Emilia Romagna Oncology 2 21 325.000 2307931 Innovative Tool for Uni compartmental Knee Prostheses & Evolution of Guidelines. RIZZOLI Surgical Sciences, Biomedical Imaging, and Bioengineering 21,25 545.000 2307650 Role of PPAR (Peroxisome Proliferator Activated Receptors) alpha ligands in modulating allergen induced inflammatory and dysfunctional alterations of the airways. MAUGERI Cardiovascular and 21,5 160.000 2318083 Conservative and surgical care pathway in patients with neuromuscular scoliosis RIZZOLI Musculoskeletal, Oral and Skin Sciences 21,5 385.600 2318607 relevance of detecting EpCAM+ tumour cells in peripheral blood and in bone marrow in patients with hepatocellular carcinoma Piemonte Digestive, Kidney and Urological Systems 21,5 300.000 2319058 Markers of gluten sensitivity in unipolar and bipolar disorders Toscana Immunology 21,5 150.000 2320969 Impact of thrombophilia on risk of perinatal stroke in neonates: a prospective study OSPEDALE BAMBINO GESU' Vascular and Hematology 21,5 400.000 2320144 Major Depression in Systemic lupus erythematosus: a possible link between neurobiological aspects and biohumoral milieu Toscana Brain Disorders and 21,5 400.000 Pagina 130 di 142

2321549 Eukaryotic translation Initiation Factor 4H /Wbscr1: its role in the aetiopathogenesis of the Williams Beuren Syndrome. Brain Disorders and 21,5 210.000 2317110 Development of a multiplex standard polymerase chain reaction assay for identification of infectious agents from aborted ruminants clinical samples Istituto Zooprofilattico Sperimentale del Mezzogiorno Veterinary 21,5 350.000 2312254 The role Inflammation and wound healing mechanisms in lung cancer biological behaviour and outcome prediction after surgical resection HUMANITAS Oncology 1 Basic 21,5 526.940 2304745 Cytokine secretion phenotype of airway immune cells in inflammatory and infectious diseases of the human lung Toscana Immunology 21,5 180.000 2315659 Study of bacterial, parasitic and viral pathogens found in animal and vegetables food matrices, currently not covered by the national and European laws, with particular reference to the list of zoonotic agents. Istituto Zooprofilattico Sperimentale della Sicilia Veterinary 21,5 600.000 2316838 EARLY NEURAL CONNECTIVITY DEVELOPMENT: A PRENATAL FUNCTIONAL MAGNETIC RESONANCE IMAGING STUDY Veneto Biology of Development and Aging 22 350.000 2299090 Prognostic role of melanoma follow upa prospective randomised study I.E.O. Oncology 2 22 598.000 2310092 In Vivo Detection of Cholangiocarcinoma at ERCP: Confocal Laser Endomicroscopy and Intraductal Aspiration. Sicilia Oncology 2 22 271.000 2313876 Imaging in clinical MR spectroscopy: reconstruction of high spatial resolution metabolic maps Toscana Surgical Sciences, Biomedical Imaging, and Bioengineering 22 216.500 2321834 Development of a new synthetic coronary bypass graft for coronary artery bypass grafting Toscana Surgical Sciences, Biomedical Imaging, and Bioengineering 22 598.950 Pagina 131 di 142

2307248 Corrective cardiac surgery in utero: a new frontier for the management of the unborn child and for perinatal medicine Toscana Cardiovascular and 22 380.200 2311485 Smoking behavior in patients with established ischemic vascular disease from the Moli sani cohort study Molise Population Sciences and Epidemiology 22 223.850 2311990 Towards the understanding of the molecular bases of HIV latency AIDS and Related Research 22 600.000 2316196 mirna and vascular diseases: role of mir149, mir155, mir31, mir126, mir17 3p in endothelial dysfunction IRCCS AOU San Martino IST (Genova) Vascular and Hematology 22 260.000 2311791 Thyroid hormone treatment as a novel therapeutic strategy to prevent post ischemic cardiac remodeling Toscana Cardiovascular and 22 600.000 2310303 Effects of sleep disturbances on the occurrence of postextubation respiratory failure and related mortality Emilia Romagna Cardiovascular and 22 350.000 2313712 Learn and live: extended training for a safer hospital HUMANITAS Healthcare Delivery and 22 233.500 2320943 Assessment of left ventricular systolic and diastolic dysfunction in patients with pre clinical and overt heart failure. Sicilia Cardiovascular and 22 467.000 2314607 Pediatric headaches: utility of "RED FLAGS" in the use of CT and MRI Sicilia Healthcare Delivery and 22 240.000 2319777 Clinic evaluation of Cervista(TM)HR HPV as Screening Test Abruzzo Interdisciplinary Molecular Sciences and Training 22 550.000 2313373 IMMUNE RESPONSE AND VDRS POLYMORPHISMS IN INFANTS AND CHILDREN EARLY SUPPLEMENTED WITH ORAL CHOLECALCIFEROL. Lombardia Immunology 22 120.000 2321984 Enhancing the efficacy and the efficiency of obesity treatment through the psicological assessment of obese patients. Piemonte Risk, Prevention and Health Behavior 22 210.000 Pagina 132 di 142

2306575 Pulmonary Rehabilitation in Lung Cancer surgical patients. SAN RAFFAELE PISANA Cardiovascular and 22 599.000 2308849 Possible role of injured vascular cell derived microvesicles on pericyte vessel destabilization. Piemonte Oncology 1 Basic 22,5 200.000 2311744 Identification of mechanisms of resistance to EGFR tyrosine kinase inhibitors in non small cell lung carcinoma (NSCLC) and monitoring the molecular evolution of lung tumors PASCALE Oncology 2 22,5 330.000 2306780 Observational prospective study of pulmonary groundglass nodules: meaning and efficacy of CAD detection for neoplastic patients. I. O. V. Oncology 2 22,5 300.000 2318332 Tubercolosis in neonates and infants: novel approach to the diagnosis and to the management. OSPEDALE BAMBINO GESU' Infectious Diseases and Microbiology 22,5 0 2320936 Pharmacogenomics of clopidogrel in acute coronary syndromes. Emilia Romagna Cardiovascular and 22,75 300.000 2318670 Asbestos dosage in biological tissues and fluids: standardization of sample preparation and analytical methods within National Health Service, Universities and Regional Environmental Protection Agencies laboratories. Toscana Population Sciences and Epidemiology 23 250.000 2321155 Olfactory dysfunction: neurophysiological, neuropsychological and functional magnetic resonance assessment for the early detection of Alzheimer's disease. Toscana Brain Disorders and 23 250.000 2320649 Evaluation of triethylamine / triethylamine oxidized (TMA / TMAO) in patients with autosomal dominant familial hypercholesterolemia (ADH) Sicilia Endocrinology, Metabolism, Nutrition and Reproductive Sciences 23 224.000 2299263 Omic's in Blastocoele Emilia Romagna Endocrinology, Metabolism, Nutrition and Reproductive Sciences 23 75.000 Pagina 133 di 142

2309812 Characterization of a mouse model of creatine transporter deficiency:development of new therapeutic strategies for an untreatable inherited disorder of metabolism STELLA MARIS Brain Disorders and 23 416.000 2307948 BACKGROUND VALUES OF ESSENTIAL TRACE ELEMENTS, TOXICANTS AND THEIR METABOLITES IN THE ITALIAN GENERAL POPULATION MAUGERI Population Sciences and Epidemiology 23 400.000 2318771 An Innovative Microchip based Deep Brain Stimulation Device for Improved Treatment and Rehabilitation of Parkinson s Patients GALEAZZI Brain Disorders and 23 431.000 2318834 WIRVA Wireless control of Internal Routes and Vital signs monitoring for patients moving within hospital Areas Sicilia Healthcare Delivery and 23 559.000 2304015 ESTABLISHMENT OF A SENIOR EMERGENCY ROOM FOR FRAIL ELDERLY AND PATIENTS WITH DEMENTIA Emilia Romagna Healthcare Delivery and 23 250.000 2318543 Visual function in newborn at term and preterm at risk of brain damage: a new neonatal assessment visual european grid and correlations with neurodevelopmental outcome at short term (Naveg Project) MONDINO Integrative, Functional, and Cognitive 23 438.000 2321647 Negative pressure therapy : model of Haealth management Hospital to territory Veneto Surgical Sciences, Biomedical Imaging, and Bioengineering 23 150.000 2320281 COMPREHENSIVE APPROACH TO THE TREATMENT OF ATRIAL FIBRILLATION: NEW MULTIDISCIPLINAR FLOW CHART FOR EARLY DIAGNOSIS AND EARLY TREATMENT Cardiovascular and 23 500.000 2320515 Obstructive sleep apnea as a cause of resistant hypertension: impact of CPAP treatment on blood pressure and number of antihypertensive medications Risk, Prevention and Health Behavior 23 275.000 2313443 Intrabone cord blood transplantation for hematological malignancies Emilia Romagna Vascular and Hematology 23 400.000 Pagina 134 di 142

2313019 Oxidative stress and fat profile in neuromuscular disorders with pediatric onset before and after a rationally modified dietary regimen. Istituto Scienze Neurologiche Brain Disorders and 23 220.000 2320873 Global prospective evaluation of the in vivo clinical efficacy and of the ex vivo bio mechanical properties of the biological meshes employed in thoracic abdominalpelvic wall reconstructive surgery. Veneto Surgical Sciences, Biomedical Imaging, and Bioengineering 23,25 0 2316834 Wnt related proteins in the peripheral blood as potential predictors of response to lithium treatment in bipolar patients. NEUROMED Brain Disorders and 23,5 225.000 2312032 research in breast cancer metastases to the brain: a multidisciplinary approach to identify molecular pathways for the development of new therapeutic strategies I.E.O. Oncology 2 23,5 340.300 2319639 From new cancer drug registries to appropriateness of care and determinants of (regional) variability: implementing a new monitoring system to evaluate evidence based guidelines Emilia Romagna Oncology 2 23,5 428.000 2315571 Echografic detection of Hepatocellular carcinoma with a 3 dimensional ultrasound with contrast media in cirrhotic patients. Emilia Romagna Surgical Sciences, Biomedical Imaging, and Bioengineering 23,5 150.000 2309709 Environmental, food related (mycotoxins) and genetic basis of Neural Tube Defects susceptibility: prevention and treatment in Italian and Sudanese/Ethiopian populations. MEDEA Brain Disorders and 23,5 600.000 2309520 Identification of molecular markers to determine new therapeutic strategies for Phase II Trials (GCP criteria) in patients with Glioblastomas NEUROMED Oncology 2 23,5 260.000 2320338 Development of methods to sub type Clostridium botulinum from animals to support epidemiological investigations and set up of a sera and vaccine bank for treatment and prevention of type C and D animal botulism Istituto Zooprofilattico Sperimentale delle Venezie Veterinary 23,5 318.800 Pagina 135 di 142

2318478 A multicentric case control study on Gastrointestinal (GI) microbiota, diet and immune system activation: effects of microbial modulation in healthy subjects and patients affected by Irritable Bowel Sydrome and Inflammatory Bowel Disease. Istituto Superiore di Sanita' Infectious Diseases and Microbiology 23,75 308.000 2311518 Effects of the prebiotic inulin in the treatment of chemotherapy induced mucositis and related alterations in gut microbiota DE BELLIS Oncology 2 24 200.000 2320777 Impact of patient's and physician's gender on the prescriptions of cardiovascular and antidiabetic pharmacological agents in a community setting Toscana Cardiovascular and 24 150.000 2316660 Identification in patients with gastric cancer of molecular events predictive of peritoneal carcinomatosis and of the response to heated intraperitoneal chemotherapy. Digestive, Kidney and Urological Systems 24 505.000 2320862 Type 2 Diabetes Mellitus and Alzheimer's Disease: towards a common treatment? Piemonte Integrative, Functional, and Cognitive 24 420.000 2315146 NICAL AND LOGICAL INVESTIGATIONS IN PATIENTS WITH PRIMARY PLASMA CELL LEUKEMIA RECEIVING A TRIPLE COMBINATION OF BORTEZOMIB, LENALIDOMIDE AND DEXAMETHASONE AS FIRST LINE TREATMENT CROB Oncology 2 24 520.000 2313154 A COMMON SCORE TO EVALUATE NICAL AND LOGICAL ASPECTS OF ACUTE MYELOID LEUKEMIA (AML) IN ELDERLY PATIENTS AIMED TO ENSURE HOMOGENEOUS DIAGNOSTIC AND TREATMENT CRITERIA IN THE HAEMATOLOGY UNITS IN EMILIA ROMAGNA. Emilia Romagna Oncology 2 24 251.111 2321805 IDENTIFICATION OF NEURODEVELOPMENTAL RISK FACTORS FROM GESTATION TO BIRTH: PRENATAL DIAGNOSIS OF NEUROLOGICAL DISEASE, MANAGEMENT IN NICU AND EARLY REHABILITATION CARE.ESTABLISHMENT OF A MULTIDISCIPLINARY DIAGNOSTIC AND THERAPEUTIC PATHWAY FOR THE NEWBO Sicilia Brain Disorders and 24 200.000 Pagina 136 di 142

2308509 Optimization of diagnostic and clinical management of patients with combined chronic obstructive pulmonary and ischemic heart disease. MAUGERI Cardiovascular and 24 450.000 2317702 Inflammation, angiogenesis and micrornas in malignant mesothelioma. Toscana Oncology 1 Basic 24 300.000 2317362 Bioethical issues in the use of the new criteria for Prodromal Alzheimer disease: disclosure of the diagnosis, clinical trials, social impact. FATEBENEFRATELLI Brain Disorders and 24 300.000 2305180 Array CGH analysis of copy number variation (CNV) in patients with Hemophilia A: possible relationship with FVIII inhibitor development CASA SOLLIEVO SOFFERENZA Genes, Genomes and Genetics 24 233.000 2300719 Virus host interaction in Influenza A and Hepacivirus infections: ecological and molecular studies Istituto Superiore di Sanita' Veterinary 24 580.000 2311499 Systemic Treatment plus Radiofrequency Ablation versus systemic treatment alone in patients with non resectable colorectal liver metastases. Emilia Romagna Oncology 2 24 150.000 2312599 Diagnosis and Management in Sicilian patients with Rare Diseases leading to Intellectual Disability: a Community evaluation and shared plan of improvement. OASI MARIA S.S. Healthcare Delivery and 24 320.000 2321575 IntraOperative Imaging Technologies (IOIT): supporting decision making process in the Italian National Health Care System (NHS) Agenzia per i Servizi Sanitari Regionali Surgical Sciences, Biomedical Imaging, and Bioengineering 24,5 353.792 2311105 Efficacy and safety of early and intensive rehabilitative interventions in patients with stroke. A randomized controlled trial SANTA LUCIA Brain Disorders and 24,5 406.000 2315776 Antimicrobial resistance and Zoonoses in Wildlife: Emerging Issues. Istituto Zooprofilattico Sperimentale del Mezzogiorno Veterinary 24,5 600.000 2321043 Targeting MicroRNA profile in cancer associated angiogenesis: new therapeutical and prognostic tools. Abruzzo Oncology 2 24,5 360.000 Pagina 137 di 142

2318387 Optimization of the number of fractions in hypofractionated external beam radiation therapy: suggestions from fitting a reoxygenation including TCP model to in vivo and to clinical data. Veneto Oncology 2 24,5 180.000 2316547 MARKERS OF ENDOTHELIAL PROLIFERATION IN BREAST AND COLORECTAL CANCERS: A NEW PROSPECTIVE FOR TARGET THERAPY. Sicilia Oncology 2 24,5 160.000 2322035 DETECTION OF C KIT ; BRAF AND N RAS MUTATION IN NAIL MELANOMA Emilia Romagna Genes, Genomes and Genetics 24,5 508.000 2316799 Characterization of extrapyramidal features in mitochondrial disorders S.CAMILLO Brain Disorders and 24,5 360.000 2320487 Epitope mapping of Pru p 3 with multiple antigen or linear peptides: new approaches for the diagnosis and follow up of patients with severe IgE mediated reactions to food Toscana Immunology 24,5 150.000 2304062 THE SIGNATURE OF TRANSCRIPTION FACTORS INVOLVED IN AGGRESSIVE OVARIAN CANCER Molise Oncology 2 24,5 450.000 2319252 Pain in post surgical hip and knee rehabilitation: occurrence, influence and basis for development and testing of a reasoned pain free therapeutic algorithm. DON GNOCCHI Musculoskeletal, Oral and Skin Sciences 25 291.000 2317897 Cognitive stimulation versus music therapy in patients with cognitive impairment secondary to multiple sclerosis or brain tumor CARLO BESTA Brain Disorders and 25 394.000 2321776 Role of peritoneal dialysis in the treatment of refractory heart failure Puglia Cardiovascular and 25 250.000 2313246 NICAL AND SOCIAL GOVERNANCE OF MIGRANTS OF MEDITERRANEAN Sicilia Healthcare Delivery and 25 550.000 2309601 Cluster randomized trial to assess the effectiveness of a population based educational campaign on stroke symptom recognition in reducing pre hospital delay. Emilia Romagna Healthcare Delivery and 25 405.245 Pagina 138 di 142

2316647 Affective symptoms dimensions and treatment outcome in unipolar and bipolar depression. Sicilia Brain Disorders and 25,5 150.000 2307352 ESTABLISHING THE IN VIVO THRESHOLD FOR AMYLOID DEPOSITION IN PRODROMAL TYPICAL AND ATYPICAL ALZHEIMER DISEASE Toscana Brain Disorders and 25,5 196.000 2315286 The role of oxytocin in anxiety disorders FATEBENEFRATELLI Brain Disorders and 25,5 194.000 2314720 IATRIS neuroscience: a critical reassessment of preclinical studies in neurologic diseases. Istituto Superiore di Sanita' Brain Disorders and 25,5 365.000 2313136 Taxi Doctor Healthcare Delivery and 25,75 214.444 2310443 Monitoring of heavy metals and nanoparticles in fishes and babyfoods of animal origin Istituto Zooprofilattico Sperimentale della Sicilia Risk, Prevention and Health Behavior 26 457.000 2315382 EXPERIMENTAL AND NICAL USE OF STEM CELLS IN THE TREATMENT OF HEART FAILURE Sicilia Cardiovascular and 26 592.000 2300809 CPAP (CONTINUOUS POSITIVE AIRWAY PRESSURE) FOR SLEEP DISORDERS IN CHRONIC HEART FAILURE Emilia Romagna Cardiovascular and 26 300.000 2316719 2316194 Identification of biomarkers to be predictive of response to anti CTLA4 treatment in the peripheral blood and tissues of melanoma patients. Pathogenesis of Multiple Sclerosis: role of Fas/FasLigand and TNFalfa/TNFR1 and TNFR2 systems in the apoptosis of T cells autoreactive to myelin PASCALE Immunology 26 400.000 NEUROLESI Immunology 26,5 550.000 2316301 Treatment of Kaposi s Sarcoma by Electrochemotherapy: and Virological evaluation SAN GALLICANO Surgical Sciences, Biomedical Imaging, and Bioengineering 26,5 200.000 2315127 Analysis of specific markers of mental health, after time by admissions to a hospital, for onset of psychiatric disorders in developmental age. Sicilia Biobehavioral and Behavioral Processes 26,75 150.000 Pagina 139 di 142

2316917 Title: Study on target therapies Impact in breast cancer patients on a wide area ofnorthern Emilia (AVEN ) Population included in the Reggio Emilia, Modena, Parma,Piacenza Tumour Registry ARCISPEDALE Oncology 2 27 0 2320411 LIMIT LOAD AND THE MECHANICAL RESPONSE TO THE PHYSIOTHERAPY TREATMENT OF THE NEURO MUSCULAR DEFICIENCY MAUGERI Bioengineering Sciences and Technologies 27 443.874 2321699 IDENTIFICATION AND ANALYSIS OF MOLECULAR MECHANISM IN SPORADIC AND FAMILIAL FORMS OF CCM. NEUROLESI Brain Disorders and 27 593.000 2308030 2313697 Development of autoantibody signatures as powerful diagnostic/prognostic biomarkers of inflammatory disorders of the nervous system Evaluation of circulating endothelial cells as a biomarker of endothelial damage in patients undergoing allogeneic stem cells transplantation (allobmt): correlation with graft versus host disease (GVHD) onset. Toscana Immunology 27 150.000 Lombardia Vascular and Hematology 27 360.000 2303818 Induced Pluripotent Stem Cells for neurodegenerative disease Abruzzo Emerging Technologies and Training in s 27 200.000 2321995 How to personalize the classic and atypical antipsychotic therapy in elderly patients affected by dementia: a pharmacogenetic study. Piemonte Brain Disorders and 27,5 300.000 2299325 Mechanisms of T lymphocyte immunomodulation: role of IL 27 in the Th1/Tc1 induction in chronic obstructive pulmonary disease (COPD) MAUGERI Cardiovascular and 27,5 330.000 2314777 Alpha Synuclein as a possible predictive and prognostic marker for Parkinson's Disease Istituto Superiore di Sanita' Brain Disorders and 28 470.000 2321242 Thermalism role in the management of arthralgia in women treated with aromatase inhibitors Piemonte Oncology 2 28 350.000 Pagina 140 di 142

2318919 Value of MR combined Imaging in assessment of early response to neoadjuvant theraphy in Locally Advanced Breast Cancer PASCALE Oncology 2 28 450.000 2316062 Randomized controlled clinical trial comparing Y90 TARE (Transarterial Radioembolisation with Y90) to sorafenib in the treatment of advanced HCC complicated with portal vein thrombosis Emilia Romagna Digestive, Kidney and Urological Systems 28,5 600.000 2321963 TREATMENT OF EARLY STAGE (I II) OROPHARYNGEAL CANCER WITH TRANSORAL ROBOTIC SURGERY VERSUS ESCLUSIVE RADIOTHERAPY: PROSPECTIVE MULTICENTER RANDOMIZED STUDY. I.E.O. Oncology 2 28,5 392.000 2311389 A MODEL TO EVALUATE EFFECTIVENESS AND APPROPRIATENESS OF DRUGS USING THE ITALIAN RFOM REGISTRY I. O. V. Healthcare Delivery and 29 90.000 2321677 Develop of new whole body Dosemeter for measuring ionizing Radiation to Operators in medical practice and of STErilizable wrist dosemeter (DROSTE) Toscana Surgical Sciences, Biomedical Imaging, and Bioengineering 29 177.000 2320977 Molecular profiles in Male Breast Cancer (MBC) Sicilia Oncology 2 29 500.000 2317955 Role of T cell subpopulations in the pathogenesis of Multiple Sclerosis NEUROLESI Immunology 29 580.000 2303887 Realization of a complete model of the cardiocirculatory system, by means of hybrid modelling, for testing implant strategies of prosthetic devices. Istituto Superiore di Sanita' Bioengineering Sciences and Technologies 29,5 272.000 2321018 An endoscopic information system for the achievement and the distribution of clinical images and video associated to the surgical procedures Sicilia Surgical Sciences, Biomedical Imaging, and Bioengineering 29,75 500.000 2314689 Prevention and treatment of atherosclerotic vascular disease in people living in the same geographical area. Veneto Vascular and Hematology 30 378.200 Pagina 141 di 142

2318221 Genotypes of Toxoplasma gondii their phylogeny, pathogenicity and transmission among wildlife, livestock and humans. Eating ectoparasites is an additional factor of risk for infection? Istituto Zooprofilattico Sperimentale del Lazio e della Toscana Veterinary 30 264.000 2316051 CONTROL AND MANAGEMENT OF LOGICAL FOOD RISKS: SETUP AND APPLICATION OF INNOVATING MODELS BASED ON TECHNOLOGICAL METHODS FOR DETECTION OF VIRUS, PARASITES AND BACTERIA Istituto Zooprofilattico Sperimentale della Lombardia e dell'emilia Veterinary 30,5 340.000 2320088 SUICIDE ATTEMPTS: FROM EPIDEMIOLOGY TO NICAL DIAGNOSIS Emilia Romagna Risk, Prevention and Health Behavior 30,5 107.000 2316272 A GROUP COGNITIVE/BEHAVIOURAL INTERVENTION FOR METABOLIC SYNDROME RISK REDUCTION, IN PATIENTS TREATED WITH ATYPICAL ANTIPSYCOTICS Emilia Romagna Biobehavioral and Behavioral Processes 30,5 298.000 2314265 Preliminary Study on Bone Tissue Regeneration in Massive Loss of Substance in MusculoSkeletal Oncology REGINA ELENA Musculoskeletal, Oral and Skin Sciences 32 500.000 2320498 ROLE OF micrornas IN THE PATHOGENESIS OF BARRETT S ESOPHAGOUS Sicilia Oncology 2 33 400.000 2310805 Screening of the genetic alterations in patients affected by high myopia Veneto Genes, Genomes and Genetics 33,5 250.000 2312897 Role of the master transcription factor Yin Yang 1 (YY1) in the diagnosis of bone lesions SDN Oncology 2 36 450.000 (3) LEGENDA : NOTA 1 = Il PI del Progetto ha richiesto un finanziamento inferiore a quello minimo previsto dal Bando NOTA 2 = Principal Investigator non è operatore SSN NOTA 3 = Il Progettoè risultato uguale ad altro progetto presentato nello stesso Bando anche se in altra sezione Pagina 142 di 142