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E UROPEAN CURRICULUM VITAE FORMAT PERSONAL INFORMATION Name Address VALENTINA GUARNERI University of Padova Dipartimento di Scienze Chirurgiche, Oncologiche e Gastroenterologiche Istituto Oncologico Veneto IRCCS Oncologia Medica 2 Via Gattamelata 64 35100 Padova Nationality Italian WORK EXPERIENCE Dates (from to) Name and address of the employer Occupation or position held 01/04/2013-onwards Università di Padova Dipartimento di Scienze Chirurgiche, Oncologiche e Gastroenterologiche Istituto Oncologico Veneto IRCCS Oncologia Medica 2 Assistant Professor Dates (from to) 11/2005-31/03/2013 Name and address of the employer Division of Medical Oncology, University Hospital, Modena Occupation or position held Assistant Professor Dates (from to) 05/2011-31/03/2013 Name and address of the employer Division of Medical Oncology, University Hospital, Modena Occupation or position held Coordinator of the Breast Unit Dates (from to) 09-12/2009 Name and address of the employer University of Texas MD Anderson Cancer Center, Dept of Breast Medical Oncology Occupation or position held Visiting Assistant Professor Dates (from to) 01-07/2005 Name and address of the employer University of Texas MD Anderson Cancer Center, Dept of Breast Medical Oncology Occupation or position held Observer Dates (from to) 2003-2005 Name and address of the employer Modena University Hospital Division of Oncology Page 1 - Curriculum vitae of

Occupation or position held Attending Physician Dates (from to) 1999-2003 Name and adress of the employer Pisa University Hospital Occupation or position held Post-graduate Specialization, Medical Oncology ACCADEMIC POSITION Dates (from - to) 11/2005-31/03/2013 Name and type of organisation Modena School of Medicine Principal subjects/occupational Clinical Oncology Title of qualification awarded Assistant Professor Dates (from - to) 11/2003-11/2005 Name and type of organisation Modena School of Medicine Principal subjects/occupational Clinical Oncology Title of qualification awarded Adjunct Professor EDUCATION AND TRAINING Dates 2006-2007 Name and type of organisation University of Modena and Reggio Emilia, Modena, Italy Title of qualification awarded post-graduation degree on "Statistics applied to clinical problems" Dates 2004-2006 Name and type of organisation University of Modena and Reggio Emilia, Modena, Italy Principal subjects/occupational Breast cancer clinical trials with biomarker evaluation Title of qualification awarded Ph.D. Clinical and Experimental Oncology Dates 1999-2003 Name and type of organisation Pisa University, Italy Title of qualification awarded Specialty Clinical Oncology, graduated 110/110 cum laude Date 2000 Title of qualification awarded Italian Medical Licensure Dates 1993-1999 Name and type of organisation Pisa University, italy Title of qualification awarded M.D. degree 110/110 cum laude Page 2 - Curriculum vitae of

Date 1993 Name and type of organisation Liceo-Ginnasio GB Niccolini-FD Guerrazzi, Livorno,ITALY Title of qualification awarded Humanistic Bachelor Degree 60/60 MOTHER TONGUE Italian OTHER LANGUAGES Reading skills Writing skills Verbal skills English ANNEXES Formal Teaching Research Grants Committee Awards Scientific Affiliations Editorial Reviewer Board Scientific Publications Formal Teaching - Clinical Oncology, School of Medicine, University of Modena and Reggio Emilia - Clinical Oncology Speciality School, University of Modena and Reggio Emilia - Clinical Biochemistry Speciality School, University of Modena and Reggio Emilia - General Surgery Specialty School, University of Modena and Reggio Emilia - Post Doctoral Fellowship in Clinical and Experimental Oncology, University of Modena and Reggio Emilia Research Grants -Co-investigator and member of the steering committee: project Short-HER: multicentric randomised phase III trial of 2 different adjuvant chemotherapy regimens plus 3 vs 12 months of trastuzumab in HER2 positive breast cancer patients. Research grant from Agenzia Italiana del Farmaco (AIFA-2006-2009, extended 2010) (PI Prof Conte) - Co-Investigator: Primary systemic therapy for early breast cancer: clinical, biological and molecular outputs (PRIN 2005-2007, project #2005067951). - Co-investigator and member of the steering committee: project Chemotherapy plus lapatinib or trastuzumab or both in HER2 + primary breast cancer. A randomized phase IIb study with biomarker evaluation. (PI Prof Conte) -Co-investigator and member of the steering committee: project Letrozole versus letrozole plus lapatinib in hormone-sensitive, HER2-2 negative operable breast cancer. A double blind randomized phase II study with biomarker evaluation (PI Prof Conte) -Co-investigator: Proteomic, genomic and biomarker expression as predictor of response to chemotherapy and molecularly targeted agents in breast cancer patients treated with preoperative therapy. Progetti Integrati Oncologia 2006 (project 04/07). Page 3 - Curriculum vitae of

International collaborations: - cooperation with Military institute of Medicine in Varsaw, to develop a gene expression profile able to predict the risk of developing brain metastases in HER2 + breast cancer patients (project coordinated by Dr Renata Duchnowska) -Collaboration with prof A. Lipton, Penn State University, Pennsylvenia, USA, in the evaluation of HER2 dimers expression from primary tumor to metastases in breast cancer patients -Cooperation with UT MD Anderson cancer center for the evaluation of the prognostic role of post-therapy Ki67 in breast cancer patients treated with neoadjuvant chemotherapy (Prof. AM Gonzalez-Angulo) Commitee - ESMO Young Oncologists Committee 2010-2012, renewed 2012-2014 - ESMO E-learning and CME Working Group: 2012-2014 - since 2010: member of the International Congress on Anticancer Treatment (ICACT) Scientific Committee - AIOM National Congress Scientific Committee: 2008; 2012: referee for breast cancer Awards - 2001 Award from Ordine dei Medici di Livorno for the best MD degree thesis - 2004: Research grant from Komen foundation Italy- Università Cattolica del Sacro Cuore di Roma for research project to be completed at the University of Texas, MD Anderson Cancer Center, Houston, Texas (Prof GN Hortobagyi) - 2004: Research award from Lega Italiana per la Lotta contro i Tumori - 2005: Young Researcher Award from Associazione Malati Oncologici - 2006: Young Researcher Award from voluntary association Cestodiciliege - 2007: Young Researcher Award from voluntary association Cestodiciliege -2009: Travel Grant from Fondazione Komen ( Prognostic role of Ki67 following preoperative chemotherapy -MD Anderson Cancer Center, Houston, Texas) - 2010: Awardee of the Unimore Monica Boscolo Research Grant (Residual tumor after preoperative chemotherapy in breast cancer as a model to study resistant micrometastatic disease) -2013: Young Researcher Award, Fondazione Guido Berlucchi Scientific Affiliations - Italian Association Medical Oncology (AIOM) - European Society Medical Oncology (ESMO) - American Society Clinical Oncology (ASCO) - EBMT (European Bone Marrow Transplantation) Editorial Reviewer Board - Annals of Oncology - Clinical Cancer Research - The Oncologist - Breast Cancer Research - British Journal of Cancer - Clinical Breast Cancer - Annals of Surgical Oncology - American Journal of Clinical Oncology - Cancer Letters Page 4 - Curriculum vitae of

- Expert Opinion on Drug Safety - Expert Review of Anticancer Therapy - Expert opinion on Pharmacotherapy - Cancer Chemotherapy and Pharmacology - International Journal of Biomedical Science - Chemotherapy - Oncology - Journal of Oncology Publications: Author or co-author of 62 full-text paper in peer-reviewed. Total Impact Factor:262, IF as first or last author: 152 (JCR-ISI WEB 2012). H Index : 22 (Anne-Wil Harzing) She is author of 4 book chapters, and co-author of 2 book chapters. Page 5 - Curriculum vitae of