1 Monday, March 18, 2013 Scientific Programme From 12.00 Registration 15.00-15.10 Opening remarks: Symposium s Organisers and Prof. Kai-Olaf Hinrichsen, Dean of Department of Chemistry, Technische Universität München 15.10-15.30 Short lecture 15.30-16.10 Opening lecture Prof. Luis Moroder, Max Planck Institute for Biochemistry Peptide chemistry in Germany: from the past to the present L1 Prof. William DeGrado, University of California San Francisco 16.10-16.40 Coffee break 16.40-17.20 Plenary lecture Design of therapeutics that act on membranes and membrane proteins L2 Prof. Thomas Carell, Ludwig-Maximilians-Universität München DNA bases beyond Watson and Crick 17.20-18.30 Short lectures (SL) on posters (16 posters / 3 min each) (SL1-SL16) 18.30-20.30 Poster viewing session I and Get Together (all posters without individual presentations) Tuesday, March 19, 2013 Session 1a: Peptides and peptidomimetics in medicine (Chair: Prof. Luis Moroder, Max Planck Institute for Biochemistry) 9.00-9.40 L3 Prof. Annette Beck-Sickinger, University of Leipzig Immobilisation and controlled release of peptide and protein therapeutics 9.40-10.00 L4 Dr. Tamis Dabre, University of Bern Cell penetrating peptide dendrimers
2 10.00-10.20 L5 Sebastian Hörner, Technische Universität Darmstadt Cube-octameric silsesquioxanes: nanoscaffolds for tumor imaging and drug delivery 10.20-10.40 L6 Prof. Roland Brock, Radboud University Nijmegen Medical Centre 10.40-11.10 Coffee break Chiral peptide variants shed light on the role of heparan sulfates in cellpenetrating peptide uptake Session 1b: Peptides and peptidomimetics in medicine (Chair: Dr. Hubert Kalbacher, University of Tübingen) 11.10-11.50 L7 Prof. John Robinson, University of Zurich Protein epitope mimetics in drug and vaccine research 11.50-12.10 L8 Prof. Jörg Rademann, Universität Leipzig Reactive peptides as tools for the identification of protein-specific small molecule fragments 12.10-12.30 L9 Dr. Maja Köhn, EMBL Heidelberg A chemical toolbox to study the phosphatase PTP1B 12.30-12.50 L10 Prof. Ines Neundorf, Universität zu Köln Synthesis and biological application of organometal complex-peptide conjugates 12.50-13.10 L11 Prof. Hans Brückner, University of Giessen 13.10-14.20 Lunch Exploring a thousand sequences of bioactive fungal peptaibols/peptaibiotics Session 2a: Peptide/protein structure, folding, and interactions (Chair: Prof. Johannes Buchner, Technische Universität München) 14.20-15.00 L12 Prof. Johannes Buchner, Technische Universität München The peptide binding properties of the molecular chaperone BiP regulate antibody assembly 15.00-15.20 L13 Dr. Felix Hausch, Max Planck Institute of Psychiatry München Biomimetic screening of class B G-protein coupled receptors 15.20-15.40 L14 Markus Ritzefeld, Bielefeld University Single molecule monitoring of peptide/protein-dna interaction dynamics by simultaneous atomic force spectroscopy and FRET analysis
3 15.40-16.00 L15 Prof. Iris Antes, Technische Universität München 16.00-16.30 Coffee break Computational prediction of protein-peptide binding Session 2b: Peptide/protein structure, folding, and interactions (Chair: Dr. Norma J. Greenfield) 16.30-17.10 L16 Prof. Thomas Kiefhaber, Technische Universität München Conformational fluctuations in peptides and proteins detected by triplet-triplet energy transfer 17.10-17.30 L17 Andreas Deeg, Ludwig-Maximilians-Universität München β-hairpin formation on the ns to µs timescale with different techniques: towards an understanding of structural dynamics in a light-triggered peptide 17.30-17.50 L18 Prof. Dieter Langosch, Technische Universität München The backbone dynamics of the amyloid precursor protein transmembrane helix provides a rationale for the sequential cleavage mechanism of γ- secretase 17.50-18.10 L19 Dr. Erik Strandberg, Karlsruhe Institute of Technology (KIT) Dynamics of membrane-bound peptides studied with solid state NMR: implications on the evaluation of helix tilt angles under hydrophobic mismatch 18.10-19.10 Poster viewing session II (with beer and pretzels): presentation of posters with odd numbers and posters to SL1-SL16 19.30 Invited speakers and chairs highlights München short city tour and dinner Wednesday, March 20, 2013 Session 2c: Peptide/protein structure, folding, and interactions (Chair: Prof. Ulf Diederichsen, Georg-August University Göttingen) 9.00-9.40 L20 Prof. Herbert Waldmann, Max-Planck-Institut für molekulare Physiologie Dynamic regulation of Ras localization and signaling 9.40-10.00 L21 Dr. Irene Coin, The Salk Institute for Biological Studies Map of the peptide binding pocket of a class B G-protein coupled receptor 10.00-10.20 L22 Andrea Groß, Friedrich-Alexander-Universität Erlangen-Nürnberg Exploring binding specificities of HIV-1 gp120 and CXCR4 through peptidepeptide interactions
4 10.20-10.40 L23 Malte Gersch, Technische Universität München 10.40-11.10 Coffee break Cleavage site preferences and ligand-induced oligomerization defects in the ClpP family of proteases Session 3: Peptide self-assembly in disease and material science (Chair: Prof. Dieter Langosch, Technische Universität München) 11.10-11.50 L24 Prof. Ehud Gazit, Tel Aviv University Molecular self-assembly of short aromatic peptides: from biology to nanotechnology and material science 11.50-12.30 L25 Prof. Bernd Reif, Technische Universität München Amyloid aggregates and interference with small molecules 12.30-12.50 L26 Dr. Yifat Miller, Ben-Gurion University Self-assembly of peptides: insight into the mechanisms and the link between amyloids diseases 12.50-13.10 L27 Dr. Franziska Thomas, University of Bristol 13.10-14.20 Lunch CC-Hex: a powerful tool for protein engineering 14.20-15.30 Short lectures (SL) on posters (16 posters / 3 min each) (SL17-SL32) 15.30-16.30 Poster session III (with coffee and sweets): presentation of posters with even numbers and posters to SL17-SL32 Session 4a: Peptide and protein synthesis (Chair: Prof. Hans Brückner, University of Giessen) 16.30-17.10 L28 Prof. Henning Mootz, University of Münster Split inteins: mechanism and applications in protein semisynthesis 17.10-17.30 L29 Peter Fransen, IRB Barcelona Pentrimers as multifunctional and multimodal platforms for diverse biomedical applications 17.30-17.50 L30 Angelina Gross, Universität Bayreuth Convergent solid phase synthesis of peptide hydrazides of glycosylated human erythropoietin 17.50-18.10 L31 Dr. Srinivas Banala, Technische Universität Berlin Studies towards the total synthesis of plantazolicin
5 18.10-18.30 L32 Friederike Inga Nollmann, Goethe Universität Frankfurt Killing two birds with one stone: a new total synthesis of xenematide A through D84 20.00 Conference dinner (Königlicher Hirschgarten, München) Thursday, March 21, 2013 Session 4b: Peptide and protein synthesis (Chair: Prof. Norbert Seewald, Bielefeld University) 9.00-9.20 L33 Florian Karch, Ludwig-Maximilians-Universität München Synthesis of tumor associated MUC1 carbohydrate antigen conjugates with fluorinated amino acids or amino acid mimics 9.20-9.40 L34 Dr. Gerbrand J. Van der Heden van Noort, Leiden Institute of Chemistry Synthetic methodology towards natural occurring post-translational modified peptides 9.40-10.00 L35 Prof. Christian Ducho, University of Paderborn Synthesis of muraymycin nucleoside-peptide antibiotics and their analogues 10.00-10.20 L36 Dr. Wolfgang Rapp, Rapp Polymere GmbH 10.20-10.50 Coffee break Preventing failure in difficult sequences: an improved resin matrix, it s properties and application Session 1c: Peptides and peptidomimetics in medicine (Chair: Prof. Jutta Eichler, University Erlangen-Nürnberg) 10.50-11.10 L37 Prof. Norbert Seewald, Bielefeld University Cytotoxic peptide-drug conjugates based on cryptophycins 11.10-11.30 L38 Dr. Stefanie Neubauer, Technische Universität München Functionalization of αvβ3- or α5β1-selective integrin ligands for medicinal and biophysical investigations 11.30-11.50 L39 Dr. Norbert Schaschke, University of Bielefeld Upgrading a natural product: inhibition of human β-tryptase by cyclotheonamide analogues
6 11.50-12.10 L40 Prof. Dieter Willbold, Research Centre Jülich and Heinrich-Heine-Universität Düsseldorf The Aβ-oligomer targeting D-enantiomeric peptide D3 is efficiently improving pathology and cognition of orally treated transgenic AD mice 12.10-12.30 L41 Prof. Florian Seebeck, Universität Basel Artificial lantipeptides 12.30-12.50 L42 Dr. Daniel Knappe, University of Leipzig Oncocin derived proline-rich antimicrobial peptide derivatives show superior activities in mice infected with Escherichia coli or Klebsiella pneumoniae and high margins of safety 12.50 Closing remarks