FOURTH ANNUAL WORLD COURSE IN ADVANCED TECHNIQUES IN NEUROSURGICAL ONCOLOGY



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- LIVE SURGERY FROM 3 COUNTRIES - 3-D ANATOMY SHOWS - HANDS ON WORKSHOPS - MASTERS SEMINARS - ROUND TABLE DEBATES - CASE DISCUSSIONS - LANDMARK RESEARCH FOURTH ANNUAL WORLD COURSE IN ADVANCED TECHNIQUES IN FOR NEUROSURGEONS AND residents WEDNESDAY July 8 - Sunday July 12, 2015 WELLCOME museum of medicine London, UK 30 CME POINTS

Cortical mapping for resection of a LGG performed by the Course Director George Samandouras

WEDNESDAY 8 JULY 2015-3D-ANATOMY SHOWS Learn the safe cortical entry points to deep-seated lesions from top experts Watch 10 hours of breathtaking 3D anatomy presentations and videos that systematically describe all critical surgical anatomy related to tumours. Time Speaker/Topic Venue 7:30-8:15 Registration and Coffee 8:15-8:30 Introduction to the Course George Samandouras, UK 8:30-9:30 Interactive 3D Anatomy Show Overview of the surgical anatomy of brain architecture Guilherme Ribas, Brazil 9:30-10:30 Interactive 3D Anatomy Show Anatomy of the cortical sulci and gyri Guilherme Ribas, Brazil 10:30-11:30 Interactive 3D Anatomy Show Opercular, temporo-mesial and sub-insular surgical anatomy Guilherme Ribas, Brazil 11:30-12:00 Coffee Break WL 12:00-13:00 Interactive 3D Anatomy Show The temporal lobe, insula and the Sylvian fissure Antonio Mussi, Brazil 13:00-14:00 Interactive 3D Anatomy Show Surgical anatomy of the lateral, third, and fourth ventricles Antonio Mussi, Brazil 14:00-15:00 Sit-down 3- course buffet lunch BRH 15:00-16:00 Interactive 3D Anatomy Show Microneurosurgery of lobal and gyral lesions Guilherme Ribas, Brazil 16:00-17:00 Interactive 3D Anatomy Show Anatomical corridors to deeply-seated intrinsic lesions Guilherme Ribas, Brazil 17:00-18:00 Ask the experts Q&A and challenging case presentation from the delegates Guilherme Ribas, Brazil Free evening for the delegates Understand topographic skull anatomy applied to brain tumour surgery, Henry Wellcome Auditorium; WL, Williams Lounge; BRH, Blue Radisson Hotel - 3 -

THURSDAY 9 JULY 2015 - LIVE SURGERY FROM USA, ITALY AND GERMANY Professor Mitchel Berger in the Operating Room of the UCSF Medical Center Professor Mitchel Berger during live surgery in July 2014 streamed to London Professor Walter Stummer performing a Gliolan-guided resection of a HGG Time Surgeon/Topic Venue 8:15-8:30 Introduction to Live Surgery George Samandouras, UK 8:30-11:30 Watch the Masters Operate Live Live surgery from Italy Lorenzo Bello, Milan, Italy Awake craniotomy for LGG with intraoperative neurophysiology and neuropsychology 11:30-14:30 Watch the Masters Operate Live Live surgery from Germany Walter Stummer, Muenster, Germany Awake craniotomy for HGG with Fluorescent (Gliolan)-guided resection with intraoperative SSEPs and MEPs 14:30-15:30 Sit-down 3-course buffet lunch BRH 15:30-18:30 Watch the Masters Operate Live Live surgery from USA Mitchel Berger, San Franscisco, USA Awake craniotomy for LGG Tumour excision with cortical mapping and neuronavigation 20:00-23:00 Drinks and canapes reception, Henry Wellcome Auditorium; WL, Williams Lounge; BRH, Blue Radisson Hotel - 4 -

FRIDAY 10 JULY 2015 - TECHNIQUES & ANATOMY (AM) AND PRACTICAL WORKSHOPS (PM) Live description of awake craniotomy techniques in the July 2014 course at the Wellcome Collection Professor Ribas giving a hands-on Masterclass on topographic skull anatomy in London, July 2014 Time Speaker/Topic Venue 8:00-8:15 Introduction to day three George Samandouras, UK 8:00-10:30 My techniques step-by-step Hugues Duffau, France Interactive live narration & discussion in London with delegates of a pre-recorded awake resection with cortical mapping of a left-sided insular glioma without neuronavigation or microscope 10:30-11:00 Coffee Break 11:00-11:45 Interactive 3D Anatomy Show Juan Martino, Spain Applied microneurosurgical anatomy of white matter tracts 11:45-12:30 Interactive 3D Anatomy Show Juan Martino, Spain Applied microneurosurgical anatomy of insular gliomas 12:30-13:15 Interactive Anatomy Show Marco Catani, UK Using DTI for virtual in vivo fibre dissections 13:15-14:15 Sit-down 3- course buffet lunch WL 14:15-16:00 Hands-on Practical Workshop - I Topographic skull anatomy Cortical Stimulation Ultrasonic Aspirators 16:00-16:30 Coffee Break BRH 16:30-18:30 Hands-on Practical Workshop - II Topographic skull anatomy Cortical Stimulation Ultrasonic Aspirators 20:00-23:00 Drinks and canapes TECHNIQUES 3D ANATOMY SHOWS HANDS ON WORKSHOPS Professor Sabel giving another Masterclass on the optimal use of ultrasonic aspirator in July 2014 course, Henry Wellcome Auditorium; WL, Williams Lounge; BRH, Blue Radisson Hotel - 5 -

SATURDAY 11 JULY 2015 - MASTERS SEMINARS (AM) AND PRACTICAL WORKSHOPS (PM) Professor Mitchel Berger will share his techniques that changed the practice of neurosurgical oncology worldwide Professor Hugues Duffau during an animated Master s Seminar in July s 2014 World Course in London One of the three-course sit-down lunch breaks at the Blu Raddison Hotel Time Speaker/Topic Venue 8:00-8:50 The Master s Seminar Mitchel Berger, USA How I do awake craniotomies for LGG 8:50-9:00 Discussion 9:00-9:50 The Master s Seminar Lorenzo Bello, Italy My techniques in awake craniotomies for LGG 9:50-10:00 Discussion 10:00-10:50 The Master s Seminar Walter Stummer, Germany How I use Gliolan for resection of HGG 10:50-11:00 Discussion 11:00-11:30 Coffee WL 11:30-12:20 The Master s Seminar Linda Liau, USA My techniques in intra-operative functional brain mapping 12:20-12:30 Discussion 12:30-13:20 The Master s Seminar Marco Catani, UK Advanced tractography; current applications and future directions 13:20-14:00 The Master s Seminar Andrea Szelenyi, Germany Intraoperative Monitoring for Neurosurgeons; established and promising new techniques 14:00-15:00 Sit-down 3-course buffet lunch BRH 15:00-16:30 Discuss with the Authors - I Interactive discussion with the senior authors of the most influential papers in neuro-oncology, as voted for by the faculty, via video-conference 16:30-17:00 Coffee 17:00-18:30 Discuss with the Authors - II 20:00-23:00 Formal Dinner with the Faculty SURGICAL TECHNIQUES TECHNOLOGIES LANDMARK PAPERS, Henry Wellcome Auditorium; WL, Williams Lounge; BRH, Blue Radisson Hotel - 6 -

SUNDAY 12 JULY 2015 - MASTER S SEMINARS (AM) ROUND TABLE DEBATES AND CASE PRESENTATIONS (PM) Time Speaker/Topic Venue 8:00-8:50 The Master s Seminar Hugues Duffau, France New insights into brain plasticity 8:50-9:00 Discussion Professor Mitchel Berger, USA giving a masterclass during interactive case discussions in July 2013 course Professors Stupp, Berger and Duffau (sitting from left to right) during round table discussion in July s 2014 course Delegates of the 2014 World Course watch absorbed Prof. Walter Stummer 9:00-9:50 The Master s Seminar Roger Stupp, Switzerland Basic research and clinical trials in Neuro-oncology; what the future holds for the medical management of brain tumours 9:50-10:00 Discussion 10:00-10:50 The Master s Seminar Sebastian Brandner, UK Pathogenesis and molecular classification of gliomas 10:50-11:00 Discussion HW 11:00-11:30 Coffee WL 11:30-12:30 The Master s Seminar Linda Liau, USA Review of landmark papers and promising research projects 12:30-13:30 Ask the Masters Challenging case presentations from the delegates with comments from the masters * 13:30-14:30 Sit-down 3-course buffet lunch BRH 14:30-15:30 The Master s Seminar Garth Cruickshank, UK Complications avoidance and management in brain tumour surgery 15:30-16:30 Round Table Prof M. Berger; Prof L. Liau; Prof. G. Cruickshank; Dr J. Rees What I have learned from my complications? 16:30-17:30 The Master s Seminar Prof Mitchel Berger, USA The Future of Neuro-oncology 17:30-18:00 Feedback and Conclusions * For details please go to www.neurosurgery-courses.com RESEARCH CONTROVERSIES, Henry Wellcome Auditorium; WL, Williams Lounge; BRH, Blue Radisson Hotel - 7 -

FEEDBACK FROM THE CLASS OF 2014 I could not have imagined a better course. I am IMPRESSED BEYOND ANYTHING I can express The Netherlands It was undoubtedly a tremendous amount of work putting together the best conference I have ever attended USA The course, the content, the venue and the COMMUNITY ATMOSPHERE you created, all VERY SPECIAL. An EXCEPTIONAL course USA I m very glad to have attended this OUTSTANDING and very informative course. It was TRULLY UNMISSABLE GERMANY 30 CME POINTS You organised an outstanding course of superior quality. I have BECOME INSPIRED to improve my patient care and techniques THE NETHERLANDS An unbeatable assembly of the SUPERSTARS of neuro-oncology GERMANY HOW TO SECURE A PLACE Participation to the full activities of the Course Course materials and Complementary registration bag CD of Neurosurgical Anatomy, courtesy of Prof. G. Ribas Wellcome Collection book Coffee breaks and lunch COURSE FEES INCLUDE Accredited by the Royal College of Surgeons of England for up to 30 CME points/hours (6 CME points/day) Drinks and food reception on 9 July Drinks and canapes on 10 July Formal dinner with the Faculty on 11 July Delegate Status COURSE FEES Qualified Neurosurgeons 1090 Residents-Fellows 890 5-day course fees including social activities PAYMENT METHODS Every year the course places are filled up very quickly. It is strongly advised that you book your place as soon as possible. 1. You can book your place and make a payment online at www.neurosurgery-courses.com The system will allow you to make payment if there is an available place. 2. For additional payment methods (cheques or bank tranfers) please go to www.neurosurgery-courses.com ADDITIONAL INFO For info related to the PAYMENTS please contact our support team at neurosurgery.courses@gmail.com For urgent issues only please call Tel +44(0) 7425 094242 Delegates of the 2014 World Course during the formal dinner at the Houses of Parliament - 8 - Visit the website www.neurosurgery-courses.com

VENUE OF THE COURSE The WELLCOME COLLECTION is a stunning medical Museum and Library, both parts of the WELLCOME TRUST. The Wellcome Trust was established under Sir Henry s will in 1936, and is now the WORLD S LARGEST independent charitable foundation funding research into human health. Wellcome Collection is the free visitor DESTINATION FOR THE INCURABLY CURIOUS. It explores the connections between medicine, life and art in the past, present and future. The venue offers visitors contemporary and historic exhibitions and collections, lively public events, the world-renowned Wellcome Library, a café, a shop and conference facilities as well as publications, tours, a book prize, international and digital projects. It is located in central London, 183 EUSTON RD, NW1 2BE, LONDON and is opposite Euston train station and close to both St Pancras and King s Cross train stations. Website www.wellcomecollection.org - 9 -

ACCOMMODATION AND TRAVEL INFORMATION HOTELS There are dozens of hotels within a half a mile radius of the venue. Delegates are responsible for making their own accomodation arrangements. To book Hotels: Contact Julie Conroy an independent and trusted travel agent who has helped numerous course delegates over the last few years. Contact Julie by email julie@intouch-international.com or call +44 (0)1756 795512 Try www.booking.com or www.expedia.com or www.trivago.com Early booking is advised. VISA St. Pancras Renaissance London 5 * * * * * (0.3 miles from venue) Pullman London St Pancras 4 * * * * (0.2 miles from venue) For requirements please go to www.ukba.homeoffice.gov.uk/visas-immigration If you require an invitation letter for VISA please contact patriciahaylockvize@gmail.com USEFUL LINKS All types of transport in London www.tfl.gov.uk Official London Visitors guide www.visitlondon.com TRAVEL IN LONDON Ibis Euston 3 * * * (0.4 miles from venue) London has excellent public transport services. Most people living in London prefer to use the underground system called the tube. Below are fast ways to get from Heathrow and Gatwick airports to the course venue served by two tube stations (Warren Street and Euston Square) The black circles in the routes below indicate change of train line at a station. Taxis are usually easy to find in London. Journey time: 15 mins Journey time: 18 mins Heathrow Airport Heathrow Express Paddington Bakerloo Line (Southbound) Change at Oxford Circus Victoria Line (Northbound) Warren Street Journey time: 6 mins Journey time: 30 mins Gatwick Airport Gatwick Express Victoria Station Victoria Line (Northbound) Warren Street - 10 - Reception (above) and dinner (below) at the Houses of Parliament at last year s World Course.

Mitchel Berger describing his surgical techniques at the Henry Wellcome auditorium, London during last year s Annual World Course in Advanced Techniques in Neurosurgerical Oncology London, July 2014

COURSE FACULTY Professor Mitchel S. Berger is Chairman of the University of California, San Francisco s (UCSF) Department of Neurological Surgery and the Kathleen M. Plant Distinguished Professor. He also is the director of the Brain Tumor Research Center at UCSF. Dr Berger s research, articles and books have changed the practice of neurosurgical oncology worldwide. Professor Linda Liau is Director of the UCLA Brain Tumor Program. Her expertise is in intra-operative functional brain mapping. Her research is focused on the molecular biology of brain tumors, gene therapy, immunotherapy, and brain cancer vaccines. Dr. Liau is the Editor-in-Chief of the Journal of Neuro-Oncology. Professor Garth Cruickshank is Professor of Neurosurgery in the School of Cancer Sciences, Birmingham, UK. His research is in immunomudulation and translational techniques. He has worked with the NCRI and European Association for Neuro-oncology to develop numerous trials for brain tumour patients. Professor Roger Stupp is Chairman of the Department of Oncology and Cancer Center, University of Zürich. He has been the lead investigator for establishing the use of temozolomide in glioblastomas and determining the predictive value of MGMT gene-promoter methylation. Dr Stupp is President of the EORTC. Professor Guilherme Ribas Sao Paulo, Brazil is an international authority in the cortical and subcortical anatomy of the brain. He is the first person who introduced the use of 3D images in brain anatomy. He is a sought after speaker in conferences and workshops around the world. Professor Hugues Duffau is Chairman of the Department of Neurosurgery in Montpellier. Prof Duffau has pushed the limits of resection on LGGs to achieve supracomplete resections even in eloquent areas of the brain His most recent book Brain Mapping explores insights of brain plasticity from cortical mapping and brain surgery. Professor Walter Stummer is the surgeon who introduced the use of Gliolan (5-ALA) in the resection of HGGs. He has published extensively and is running numerous national and international trials. He is Head of the Department of Neurosurgery at the University of Munsten, Germany. Professor Lorenzo Bello leads the Brain mapping group and the Surgical Epilepsy group at the University of Milan, Italy. His surgical interests are intraoperative neurophysiology and imaged guided surgery. His research includes identification of molecular determinants of glioma angiogenesis and progression. Professor Andrea Szelenyi is Head of Clinical and Intra-operative Neurophysiology in the Neurosurgical Clinic at the University Hospital Düsseldorf, Germany. She is the President Elect of the International Society of Intraoperative Neurophysiology. Dr Antonio Mussi is an international authority in applied neurosurgical brain anatomy. He has spent years performing exclusively brain dissections with Albert Rhoton in Florida, USA. He runs successful courses in Brazil and Portugal. He practices neurosurgery in Brazil. Professor Sebastian Brandner, Head of the Division of Neuropathology at the National Hospital, and the UCL Institute of Neurology, London is a leading investigator on brain tumours, with major success in developing experimental models of brain tumours. Dr Juan Martino is a leading expert in the dissection of subcortical white matter tracts. His research and outstanding anatomical speciments have been published in numerous highly-cited articles and monographs. Dr Marco Catani is one of the world s leading authorities on DTI on brain anatomy and language. He pioneered the use of diffusion tractography to identify new connections in the human brain. He is the Head of the NatBrainLab (www.natbrainlab.com) at the Institute of Psychiatry, King s College London. For more info about faculty members please go to www.neurosurgery-courses.com COURSE DIRECTOR KIND COURSE SPONSOR George Samandouras, London, UK Consultant Neurosurgeon, Co-Director of Neurosurgery Victor Horsley Department of Neurosurgery The National Hospital for Neurology and Neurosurgery Queen Square, London