Plan and manage clinical trials with clarity and confidence

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Plan and manage clinical trials with clarity and confidence Accurately identify opportunities and avoid obstacles throughout the clinical trial process with IMS Health Clinical Trial Optimization Solutions IMS Health Clinical Trial Optimization Solutions

Deliver on-time, on-budget clinical trials by confidently planning and managing the process using real-time insights Clinical trials habitually run over schedule and over budget. The costs of trial over-runs are staggering: an average of $35,000 per day delay, plus the millions in lost revenue opportunities. Map the best course WITH EARLY feasibility and planning clinical trial challenges 48% of trial sites miss enrollment targets * 80% of trials run behind schedule 11% of investigators never enroll a patient Grants increase an average of 7% per year * Tufts Center for the Study of Drug Development, 2013 Now, using IMS Health Clinical Trial Optimization Solutions, you can efficiently model multiple courses of action using the most complete global data with the full understanding of fair market value and standard of care. Negotiate grants with confidence with the full understanding of fair market value and standard of care to ensure full reimbursements. Then, develop several pathways to take your trial from plan to completion, and compare the time and cost consequences of each. Adjust to changing conditions without excessive delay and cost As your trial moves forward, leverage IMS Health Clinical Trial Optimization Solutions to identify any new challenges or opportunities, based on changing conditions. Compare options to discover the fastest and least expensive alternatives to help keep your trial on track for successful completion. IMS Health Clinical Trial Optimization Solutions enables early identification of trial challenges, allowing you to make informed action plans to avoid them. To learn more about this powerful suite of data-driven software solutions, call 484.567.6343 or email your questions to clinicaltrials@imshealth.com.

COLLECTIVE, ANONYMIZED CLINICAL TRIAL PERFORMANCE DATA AVAILABLE TO THOSE CTOS CLIENTS WHO AGREE TO SHARE THEIR DATA AT STUDY END. CURRENTLY INCLUDES INFORMATION FROM COMPANIES THAT COLLECTIVELY CONDUCT 76 PERCENT OF ALL GLOBAL CLINICAL TRIALS INDUSTRY BENCHMARKS 400 MILLION GLOBAL PATIENT LIVES HEALTH PLAN LONGITUDINAL RX ONCOLOGY EMR N EMR LAB ONCOLOGY SURVEY MEDICAL SURVEY MEDICAL PHARMACY 200 MILLION HOSPITAL & CLINIC CLAIMS MORE THAN 860,000 PHYSICIANS 1 BILLION PHYSICIAN CLAIMS A YEAR PLUS: YOUR HISTORICAL CLINICAL TRIAL DATA PUBLIC DOMAIN RECORDS 100,000 individual sources & suppliers 17.5 petabytes of data annually 39 billion healthcare transactions per year 1,000+ biostatisticians, analysts, economists, clinicians & other advanced experts 5,000+ projects per year, serving the top 15 pharma companies Clinical trial forecasting Powered by the extraordinary healthcare data resources from IMS Health Accurate forecasting and planning start with insights into the difficulties that can be foreseen and the actions that are taken to address or avoid them. These insights come from leveraging multiple types of data, analyzed to enlighten the problem set and used at key points in the decision process. IMS Health offers you the most extensive healthcare data resources in the world, checked and standardized through the most rigorous and advanced systems in the industry. Clean, HIPAA compliant and standardized through IMS Health protocols for the most consistent and accurate outcomes.

Forecast, manage and report on your studies with confidence Assess with a 360-degree view of your market landscape Competitive and Market Intelligence Incidence and prevalence Competing products currently on the market Analysis and feasibility services Analyze variables that impact your ability to execute I/E criteria analysis Site profiling Patient profiling Risk factors to recruitment Standard of care impact Recruitment and retention challenges Operationalize with real-time insights to optimize your course and ensure delivery against plan Competitive landscape monitoring Course correction insights based on market data Enrollment Planning and Forecasting IMS Health StudyOptimizer TM and SiteOptimizer TM Industry enrollment benchmarks Industry dropout rates Site identification in relevant indication Site start-up and performance metrics Site access to relevant patients Site-to-patient proximity Operational plan time and cost impact Optimal start-up plan and contingencies Optimal country allocations KPI correlations Real-time forecasts of trial completion Budget projections Rescue plan modeling Patient recruitment campaign ROI Protocol amendment impact Contingency site analysis and recommendations Cost Benchmarking and Forecasting IMS Health GrantPlan TM, StandardOfCare TM, CostPro TM and IISiS TM Fair market value of investigator grants Procedures routinely covered by thirdparty insurers in a given indication Site-level counteroffer and comments Grant negotiation timelines Fair market value of outsourcing activities Fair market value of activities in investigator-initiated studies Detailed line item costs Forecasting for cost per patient by phase, indication and country Industry benchmarks and historical data for sites and activity level Standard of care procedure details by visit Cost analysis per study by category, pass-throughs Country and site-level overhead Current negotiation status CRO RFP analysis and evaluation Detailed site-level budgets, long-range forecasting and cost containment Country and site allocation feasibility and compliance considerations Ongoing budget management, adjustment and justification Investigator grant negotiation and status CRO RFP status and selection Data to support Sunshine Act requirements Full-Service Data-Driven Software Solutions Recommended country participation Operational impact of competitive products development of site list vs. site master file Locate target subjects and sites Conduct early risk analysis Recommended operational plan SWOT analysis of program plan Recruitment and retention considerations Management of strategy, enrollment performance and cost Seamless service offering with dedicated FTE

IMS Health StudyOptimizer TM Optimal Enrollment Plans Model various enrollment alternatives and their budget impacts predict enrollment outcomes with precision based on study performance Monitor and report on progress Based on the predictive forcast, will we achieve the plan goal? What procedures in our trial can be reimbursed through various insurance plans, and at what level? How much should we be saving? IMS Health StandardOfCare TM Achieve 20% Savings Avoid paying study sites for procedures that are routine care for a trial subject The only tool on the market that identifies standard of care procedures with a single click based on roughly a billion physician claims and another 200 million hospital and clinic claims Addresses private and public insurance plans use of this tool has led to published savings of 20% in a typical Phase III Study Focus on THE analysis with HELP FROM THE IMS HEALTH implementation & support TEAM What plan variables impact time and cost? FEASIBILITY DATA, ANALYTICS + TECHNOLOGY CORRECTIVE ACTION PLANS IMS Health SiteOptimizer TM Productive Sites pinpoint investigators and sites with a track record of success Avoid nonproductive sites or those that have compliance issues easily identify the patient location for specific diseases Identify investigators with the most patients for certain indications IMS Health GrantPlan TM Confident Negotiation eliminate grant guesswork review by procedure, visit, patient level and more Track and manage all your grants through the course of the study based on most recent actual budgets Better forecasting from better data > Installation and configuration support, including data mapping > Integration of your historical data > Training and troubleshooting MANAGE TO PLAN FORECASTING Which sites consistently float to the top of our trials? Which sites have access to the most patients for specific diagnoses? What are investigators currently paid for similar studies by procedure, country, patient? How can we be sure we re negotiating fair market rates? > Study support, such as helping with benchmarking and analysis

IMS Health Clinical Trial Optimization Solutions IMS Health One IMS Drive Plymouth Meeting, PA 19462 USA Tel: +1 855 342-0016 ClinicalTrials@imshealth.com For all office locations, visit: www.imshealth.com/locations About IMS HEALTH IMS Health is a leading worldwide provider of information, technology, and services dedicated to making healthcare perform better. With a global technology infrastructure and unique combination of real-world evidence, advanced analytics and proprietary software platforms, IMS Health connects knowledge across all aspects of healthcare to help clients improve patient outcomes and operate more efficiently. The company s expert resources draw on data from nearly 100,000 suppliers, and on insights from 39 billion healthcare transactions processed annually, to serve more than 5,000 healthcare clients globally. Customers include pharmaceutical, medical device and consumer health manufacturers and distributors, providers, payers, government agencies, policy makers, researchers and the financial community. Additional information is available at www.imshealth.com. 2014 IMS Health Incorporated and its affiliates. All rights reserved. Trademarks are registered in the United States and in various other countries.