the center for advancing innovation

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the center for advancing innovation Discussion Document: Nano Startup July 6, Challenge 2009 in Cancer (NSC 2 ) Overview By: Rosemarie Truman, Founder and CEO, The Center for Advancing Innovation OCTOBER 2 nd, 2015

Goals of The NSC 2 Nanotechnology and Cancer Focus: Accelerate the translation and development of nanotechnology solutions for the early detection, diagnosis, and treatment of cancer Collaborative Environment: Advance the translation of cancer nanotechnologies by developing collaborations* between industry, research, academia, etc. and creating a forum for knowledge exchange Economic Growth: Spur economic growth through new startups and jobs Entrepreneurship Learning: Provide entrepreneurial education programs for scientists Business Model: Leverage new business model to advance Federally-funded inventions through startup challenge Technology Transfer Memorandum: Accelerate and increase the volume of Federally funded technology transfer in support of high growth businesses *involving not only the Federal Government but also companies, health systems, patient advocacy organizations, philanthropists, state governments, research universities, private research institutes, and scientific societies 2

Overview of Phases: 500+ people enter; we expect approximately 15 startups Oct. 12 th 2015 Feb 11 th Phase 0: Enter Challenge 30 Teams per Invention Feb. 12 th Apr. 4 th Phase 1: Elevator Speech 5 Teams per Invention Move Forward Apr. 5 th Jul. 18 th Phase 2: Business Plan 3 Teams per Invention Move Forward- Jul. 19 th Aug. 28 th Phase 3: Startup Up to 3 Startups for Each Invention Post Aug. 28 th Post-Contest Startup Winner Has Licensing Agreement and Seed Funding Invention 1 Invention 1 Teams: Select an NIH furnished invention or find an invention* Form a team involving medical, business and entrepreneur disciplines Enter challenge CAI provides training and mentoring Teams produce: Elevator speech Executive summary Entries undergo public voting CAI evaluates CAI conducts continued training Advisors perform Q&A Teams produce a Business Plan and associated pitch Judges evaluate proposals/teams and select winners CAI provides prize Winners and finalists: Revise Business Plans Launch startup Raise seed funding leveraging investors CAI has established Apply for a license Enter accelerators New startups: Potential to collaborate with inventors** Develop and commercialize a product Impact the standard of care 3 *Inventions can be found in the USPTO and criteria are listed on http://www.nscsquared.org **Collaboration agreements will need to be negotiated with the NIH; the NIH is not obligated to enter into a collaboration and/or licensing agreement

Partners of the Nano Challenge and Past Challenges Challenge Partners Judges and Advisors (Past Challenges) NCI partnered with CAI to launch the Neuro and Breast Cancer Startup Challenges, and provided inventions that were the bases of both challenges. The Nano Startup Challenge in Cancer will involve inventions from NCI, NIBIB, and academia. Mission to accelerate and increase the volume of invention commercialization. Holds nine Partnership Intermediary Agreements across HHS to identify promising inventions and assist in commercialization. Partnered with NIH to orchestrate the Breast Cancer and Neuro Startup Challenges in the past. 4

We have several testimonials from the participants of past challenges Participating in the Neuro-Startup Challenge these past few months has broadened the horizons of each team member of NeuroCognetix, and inspired new goals and desires for commercializing new technologies through successful startup businesses. The Challenge provided an interesting learning experience and a compelling opportunity to interact with accomplished business leaders, NeuroCognetix The Neuro Startup Challenge originally offered us an avenue to learn about Biotechnology and Small Businesses through a hands-on experience. We were able to apply our different backgrounds to start a business. However, by the end, the challenge offered us something so much more. With their mentoring and relationships, the Neuro Startup Challenge gives EncepHeal Therapeutics the opportunity to help over 22 million people affected by substance abuse, many of which, do not have options when it comes to FDA treatments, EncepHeal The Breast Cancer Startup Challenge (BCSC) has truly been the greatest experience of my academic and professional career. I have been successful in many academic competitions in the past, however the BCSC has set up teams for success unlike any other competition Going forward, we should all look forward to the foundation of many great startups from similar CAI and NIH Startup Challenges. OncoLinx I feel that the Breast Cancer Startup Challenge (BCSC) is one of the most well-organized start-up challenges conducted. Right from initial selection of participating teams until announcement of winners and subsequent start-up mentorship, at each step, Rosemarie and her team represent clarity of vision, structured planning and near perfect implementation, Heragen 5

How you can participate? 1. Tell your friends and colleagues from your alma mater, labs, etc. 2. Spread the news while attending conferences 3. Update your LinkedIn network to encourage participation 4. Suggest a Mentor, Advisor, or Judge for the Challenge here: https://form.jotform.com/52824326349964 5. Participate: Form a team and enter Be a mentor, judge and/or advisor Elevator Speech Phase: Provide constructive criticism to teams Business Plan Phase: Listen in on one of the live pitches Nanotechnology Startup Challenge in Cancer Find Team Members Here 6