TCT2012 program. October 22-26, Miami Beach Convention Center Miami, FL.

Transcription

1 TCT2012 program The World s Premier Interventional Experience October 22-26, 2012 Miami Beach Convention Center Miami, FL

2 Resolute Integrity ZOTAROLIMUS-ELUTING CORONARY STENT SYSTEM

3 * Based on bench test data on file at Medtronic, Inc. Per the Resolute Integrity DES Indications for Use.

4 Indications The Resolute Integrity Zotarolimus-Eluting Coronary Stent System is indicated for improving coronary luminal diameters in patients, including those with diabetes mellitus, with symptomatic ischemic heart disease due to de novo lesions of length 27 mm in native coronary arteries with reference vessel diameters of 2.25 mm to 4.20 mm. Contraindications known hypersensitivity or allergies to aspirin, heparin, bivalirudin, clopidogrel, prasugrel, ticagrelor, ticlopidine, drugs such as zotarolimus, tacrolimus, sirolimus, everolimus or similar drugs or any other analogue or derivative polymer or its individual components angioplasty balloon or proper placement of the stent or stent delivery system Warnings stent implantation procedures, which include subacute and late vessel thrombosis, vascular complications recommended antiplatelet therapy. Precautions placement should only be performed at hospitals where emergency coronary artery bypass graft surgery can of the stent implantation should be assessed for patients with a history of severe reaction to contrast agents. Indications for Use, patient outcomes may differ from the results observed in Indications for Use, patients and lesions outside of the labeled indications, including more tortuous anatomy, may have an increased Care should be taken to control the position of the guide catheter tip during stent delivery, deployment, and The safety and effectiveness of the Resolute Integrity stent have not yet been established in the following with longer than 24 months of follow-up The safety and effectiveness of the Resolute Integrity stent have not been established in the cerebral, carotid or peripheral vasculature. Potential Adverse Events Adverse Events Related to Zotarolimus Instructions for Use for more information regarding indications, warnings, precautions and potential adverse events. CAUTION: at the toll-free numbers or websites listed. Medtronic, Inc. Tel: LifeLine Customer Support Product Services Trademarks may be registered and are the property of their respective owners. SAVE THE DATE FOR 2012 HONORING THE AMERICAN COLLEGE OF CARDIOLOGY AND SPECIAL GUESTS FRIDAY, DECEMBER 14, :30 PM Cocktails, Dinner, and Dancing 2 MANDARIN ORIENTAL TIME WARNER CENTER 80 COLUMBUS CIRCLE NEW YORK, NY FOR MORE INFORMATION, PLEASE CONTACT IRMA DAMHUIS AT OR [email protected].

5 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics 3

6 Table of Contents 4 Overview TCT for Surgeons, Nurses/Technologists, and Fellows...6 Directors and Organizers...8 Associations and Affiliations...10 Acknowledgments...12 Commercial Support...19 Special Activities...20 Learning Labs...22 ACC and CRF Joint Activities...24 CME/CNE Information...26 TCT 2012 Awards...28 TCT Week at a Glance...29 Faculty International Faculty...33 TCT Advisory Faculty...40 United States Faculty...41 Live Case Sites and Operators/Factoid Faculty...49 Sunday ABCs of Interventional Cardiology: An Introductory Course...50 Monday Board Review Course with Self-Assessment for Interventional Cardiology with Concepts of Endovascular Therapy (Part 1)...52 TCT for Nurses and Technologists 21st Annual Cardiovascular Nurse and Technologist Symposium...52 Registered Cardiovascular Invasive Specialists (RCIS) Review Course...53 Scientific Symposia Chronic Total Occlusions: Evolutionary Approaches...53 Core Training Curriculum in Clinical Research...54 Endovascular Intervention 2012 (Part 1)...56 Interventional Innovation: Novel Therapies and the Best New Device Concepts for Left Main and Bifurcation Stenting: An Advanced Operator s Workshop...60 Strategies for Cardiovascular Repair: Stem Cells and Beyond...61 The Drug-Eluting Stent Summit: Appropriate Utilization of Current Generation Devices...62 The Valvular Heart Disease Summit (Part 1): Aortic Valve Therapies...64 PFO and ASD Closure: Evolving Indications, Patient Selection, Devices, and Techniques...66 Special Twilight Sessions Featured Clinical Research I...67 Featured Clinical Research II...67 Focus on India: Interactive Case Review and Panel Discussion...67 Approach to Complex PCI and STEMI: From Revascularization to Complication Management...68 How to Treat Complex Coronary Lesions...68 Left Main and Bifurcation Stenting: Integrated Use of FFR and IVUS...68 Snapshot of Latin America Practice and Research...69 TCT Russia...69 The Elderly Patient: Better Treatment in the United States or Europe?...69 Tuesday Breakfast Meetings Special Sessions SCAI ELM Session...72 Board Review Course with Self-Assessment for Interventional Cardiology with Concepts of Endovascular Therapy (Part 2)...72 TCT for Nurses and Technologists Breakout Symposium I. The Great Debates...73 Breakout Symposium II. Leadership Session: Integration and Innovation...73 Scientific Symposia Surgical, Interventional, and Hybrid Procedures (Part 1): Coronary Intervention...74 Peer-Reviewed Research Poster Abstract Sessions...74 Challenging Case Video Presentations...98 Oral Abstract Sessions Presentation Theater Scientific Symposia Endovascular Intervention 2012 (Part 2) First-in-Human Studies: Global Regulatory and Translational Considerations Hot Topics in Cardiology: ACC.12 with TCT Highlights for the Interventional, Invasive, and General Cardiologist Identifying the High-Risk Patient and Lesion: From Vulnerable Plaque to Ischemia Interventional Heart Failure Launching and Sustaining Your Career Left Atrial Appendage Closure: Indications, Devices, and Techniques Next-Generation DES and Bioabsorbable Scaffolds The Valvular Heart Disease Summit (Part 2): Mitral Valve Therapies Transradial Angiography and Intervention: From Basic to Advanced Evening Programs Wednesday Breakfast Meetings Main Arena How to Treat Theater: Coronary Artery Disease How to Treat Theater: Structural Heart and Endovascular Disease International Multiplex Theater Challenging Case Theater Challenging Case Theater Maintenance of Certification (MOC) Course Special Sessions Japan-US Synergies in Global Medical Device Innovation: Harmonization by Doing (HBD) at TCT Edited Taped Case Presentations Challenging Case Video Presentations Presentation Theater

7 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics Morning Spotlight Sessions Deep Dive: Stroke Prevention Therapies From Clinical Trial Evidence to Clinical Practice: Unraveling the Issues Innovative Surgical Techniques and Technologies Next-Generation Transcatheter Mitral Valve Therapies The Use and Abuse of Appropriate Use Criteria (AUC): A Case-Based Tutorial Lunchtime Activities Hot Topics Learn the Technique Challenging Case Video Presentations Afternoon Spotlight Sessions Deep Dive: Hypertension and Renal Artery Denervation Next-Generation Transcatheter Aortic Valve Therapies Optimizing Use of Today s Antithrombotic and Antiplatelet Drugs in ACS and PCI Surgical, Interventional, and Hybrid Procedures (Part 2): Valvular and Structural Heart Disease The Skeptic s Corner: Controversies in Interventional Cardiology Evening Programs Thursday Breakfast Meetings Main Arena How to Treat Theater: Coronary Artery Disease How to Treat Theater: Endovascular and Structural Heart Disease Theater International Multiplex Theater Challenging Case Theater Challenging Case Theater Maintenance of Certification (MOC) Course Special Sessions FDA Town Hall Meeting Morning Spotlight Sessions Alcohol Septal Ablation Symposium Aortic Aneurysm Repair and Stent-Graft Devices Integrating IVUS and FFR into Clinical Practice Primary PCI for STEMI: Drugs, Devices, and Technique Controversies Edited Taped Case Presentations Challenging Case Video Presentations Presentation Theater Lunchtime Sessions Hot Topics Learn the Technique Challenging Case Video Presentations Afternoon Spotlight Sessions Drug-Coated Balloons (DCB): Clinical Data and Applications International Debating Chamber: Interventional Cardiology on Trial Next-Generation Intravascular Imaging and Physiology: RF-IVUS, OCT, NIR Spectroscopy, ifr, and CT-FFR Evening Programs Friday Breakfast Meetings Main Arena How to Treat Theater: Coronary Artery Disease Morning Spotlight Sessions RESPECT and PC Trial Deep Dive: Implications for PFO Closure to Prevent Cryptogenic Stroke TAVR Site Readiness: Starting a Program and Achieving Optimal Outcomes The STEMI Center of Excellence: Strategies to Optimize Outcomes in AMI Lunchtime Sessions Hot Topics Learn the Technique Satellite Symposia Tuesday Breakfast Meetings Presentation Theater Programs Evening Programs Wednesday Breakfast Meetings Presentation Theater Programs Evening Programs Thursday Breakfast Meetings Presentation Theater Programs Evening Programs Friday Breakfast Meetings Maps Poster Abstracts (Hall D) Map Miami Beach Convention Center

8 TCT For Surgeons TCT for Fellows TCT for Nurses/Technologists TCT: An Integrated Course for Surgeons and Interventionalists Monday The Valvular Heart Disease Summit (Part 1): Aortic Valve Therapies...64 Tuesday Surgical, Interventional, and Hybrid Procedures (Part 1): Coronary Intervention...74 The Valvular Heart Disease Summit (Part 2): Mitral Valve Therapies Wednesday Innovative Surgical Techniques and Technologies Surgical, Interventional, and Hybrid Procedures (Part 2): Valvular and Structural Heart Disease Thursday Aortic Aneurysm Repair and Stent-Graft Devices Special TCT Sessions for Cardiology Fellows Monday Board Review Course with Self-Assessment for Interventional Cardiology with Concepts of Endovascular Therapy (Part 1)...52 Tuesday Board Review Course with Self-Assessment for Interventional Cardiology with Concepts of Endovascular Therapy (Part 2)...72 Wednesday Maintenance of Certification (MOC) Course Thursday Maintenance of Certification (MOC) Course TCT for Nurses and Technologists Monday 21st Annual Cardiovascular Nurse and Technologist Symposium...52 Registered Cardiovascular Invasive Specialists (RCIS) Review Course...53 Tuesday Breakout Symposium I. The Great Debates...73 Breakout Symposium II. Leadership Session

9 5 Reasons to attend TCT 1 Late Breaking Clinical Science Late Breaking Trials and First Report Investigations A cornerstone of every TCT, late breaking trials are typically the initial worldwide presentation of clinical trials, impactful single-center or multicenter registries, or important follow-up data from major randomized trials and first-in-man experiences with novel devices or drugs. Special Twilight Sessions Continuing to grow in popularity, Special Twilight Sessions are can t-miss evening sessions that highlight featured clinical research and presentations on the hottest topics in a more casual setting with hors d oeuvres. Dedicated Oral, Poster, and Challenging Case Video Abstract Presentations TCT 2012 will feature a four-hour block dedicated to oral and poster abstract presentations and, new this year, challenging case video abstracts. This will provide the opportunity to interact with peers in an intimate setting for critical review of science. 2 Practical Knowledge How to Treat Live Case Theaters For practitioners desiring a state-of-the-art review of contemporary interventional practice, TCT s How to Treat Live Case Theaters are there to provide step-by-step approaches to basic and advanced interventions, covering a broad knowledge base as well as numerous new techniques and tips and tricks to improve care for patients with cardiovascular disease. International Multiplex Theater Multiple international societies representing the global spectrum of interventional cardiology will present their most challenging cases at TCT Networking With Colleagues Attendees consistently report that participating at TCT provides them with a platform to develop their professional and personal networks. Hospitals, institutions, and companies from around the world are represented in ever-larger numbers. You can connect with your fellow attendees in person or use the CRF Mobile App to build your own professional network with TCTMD Connect. 4 Focused Educational Activities 15th Annual Interventional Cardiology Board Review Course with Self-Assessment and Maintenance of Certification (MOC) Sessions The world-class Board Review Course with Self-Assessment at TCT 2012 will offer a thorough primer on the core components of interventional cardiology and endovascular therapy. 21st Annual Cardiovascular Nurse and Technologist Symposium The Annual Nurse and Technologist Symposium provides a forum for discussion of the latest advances in interventional, pharmacologic, structural heart, and endovascular strategies for the management of the cardiovascular patient. TCT: An Integrated Course for Surgeons and Interventionalists This is an in-depth course presented during TCT 2012 that focuses on novel and advanced surgical techniques for surgeons, interventionalists, and all others interested in the most contemporary surgical techniques and catheter-based approaches. 5 Interactive Meeting Technology CRF Meetings Mobile App To stay up to date with everything TCT has to offer, download the CRF Meetings Mobile App from itunes for iphone/ipad or Google Play for Android phones/tablets. The free TCT mobile app is available from itunes using the keyword TCT. A mobile Web site is available for those not using Apple products. Smart Tags With your mobile device, access detailed information on the go including late breaking trial slides as well as other presentations, exhibitor details and locations, and useful tips on Miami and the Miami Beach Convention Center. 7

10 Directors and Organizers Directors Martin B. Leon, MD Gregg W. Stone, MD Co-Directors George D. Dangas, MD, PhD William A. Gray, MD Roxana Mehran, MD Gary S. Mintz, MD Associate Directors Alexandre Abizaid, MD, PhD Bagrat Alekyan, MD, PhD Gary M. Ansel, MD Sorin J. Brener, MD David J. Cohen, MD Antonio Colombo, MD Elazer R. Edelman, MD Michael D. Ezekowitz, MB, ChB, DPhil Ted E. Feldman, MD Run-Lin Gao, MD Philippe Genereux, MD Bernard J. Gersh, MB, ChB, DPhil C. Michael Gibson, MD A. Marc Gillinov, MD Juan F. Granada, MD Liliana R. Grinfeld, MD Eberhard Grube, MD Marian C. Hawkey, RN James B. Hermiller Jr, MD Ziyad M. Hijazi, MD, MPH David Hildick-Smith, MD David R. Holmes Jr, MD Alice K. Jacobs, MD Michael R. Jaff, DO Pieter Kappetein, MD, PhD Barry T. Katzen, MD Dean J. Kereiakes, MD Ajay J. Kirtane, MD, SM Susheel Kodali, MD Ran Kornowski, MD Alexandra J. Lansky, MD Chaim Lotan, MD Michael J. Mack, MD Akiko Maehara, MD Oscar Mendiz, MD Ian T. Meredith, MBBS, PhD David J. Moliterno, MD Masahiko Ochiai, MD, PhD Manish Parikh, MD Seung-Jung Park, MD, PhD LeRoy E. Rabbani, MD Mark Reisman, MD Patrick W. Serruys, MD, PhD Ashok Seth, DSc Sigmund Silber, MD Robert J. Sommer, MD Corrado Tamburino, MD, PhD Paul S. Teirstein, MD Martyn R. Thomas, MD Alec S. Vahanian, MD Renu Virmani, MD John G. Webb, MD Giora Weisz, MD Christopher White, MD Harvey D. White, MD Mathew Williams, MD Stephan Windecker, MD Scientific Committee David H. Adams, MD Dominick J. Angiolillo, MD, PhD Josef Bartunek, MD, PhD Eric R. Bates, MD Olivier F. Bertrand, MD, PhD Deepak L. Bhatt, MD, MPH William E. Boden, MD Steven F. Bolling, MD Russell A. Brandwein, RPA-C Emmanouil S. Brilakis, MD, PhD Ralph G. Brindis, MD, MPH Todd J. Brinton, MD Bruce R. Brodie, MD Lutz Buellesfeld, MD Daniel Burkhoff, MD, PhD Jacques Busquet, MD Josep Rodés-Cabau, MD Christopher P. Cannon, MD Louis A. Cannon, MD John D. Carroll, MD David A. Cox, MD Michael E. Crawford, MD Frank J. Criado, MD Michael D. Dake, MD Justin E. Davies, MBBS, MRCP Henricus J. Duckers, MD, PhD Mark A. de Belder, MD, MA Bernard de Bruyne, MD, PhD Elazer R. Edelman, MD, PhD Andrew Farb, MD David P. Faxon, MD William F. Fearon, MD Francisco Fernandez-Aviles, MD, PhD Michael A. Fifer, MD Peter J. Fitzgerald, MD, PhD John M. Flack, MD, MPH William J. French, MD Anthony H. Gershlick, MD James A. Goldstein, MD Christopher B. Granger, MD J. Aaron Grantham, MD Giulio Guagliumi, MD Michael Guiry, RPA-C Paul A. Gurbel, MD Christian W. Hamm, MD Martial Hamon, MD Kishore J. Harjai, MD Marian C. Hawkey, RN Ziyad M. Hijazi, MD, MPH W. Craig Hooper, PhD Yong Huo, MD Yang-Soo Jang, MD, PhD Peter Juni, MD David E. Kandzari, MD Samir R. Kapadia, MD Aaron V. Kaplan, MD Saibel Kar, MD John W. Karanian, PhD Sanjay Kaul, MD Morton J. Kern, MD Raghu Kolluri, MD Ran Kornowski, MD Hans Krankenberg, MD Mitchell W. Krucoff, MD Henry Krum, MBBS, PhD Jean-Claude Laborde, MD Massoud A. Leesar, MD Thierry Lefevre, MD JoAnn Lindenfeld, MD William L. Lombardi, MD Yves R. Louvard, MD Francesco Maisano, MD Ganesh Manoharan, MD Steven P. Marso, MD James B. McClurken, MD John A. McPherson, MD Shamir R. Mehta, MD, MSc D. Christopher Metzger, MD James K. Min, MD Neil E. Moat, MD Marie-Claude Morice, MD Sherif F. Nagueh, MD Srihari S. Naidu, MD Brahmajee K. Nallamothu, MD, MPH Jagat Narula, MD, PhD Hilary Nierenberg, NP, MPH Patrick T. O Gara, MD E. Magnus Ohman, MD Semih Oktay, PhD Jeffrey W. Olin, DO John A. Ormiston, MB, ChB Manish A. Parikh, MD Helen Parise, ScD Amit Patel, MD, MS Tejas Patel, MD Marc S. Penn, MD, PhD Nicolo Piazza, MD Nico H.J. Pijls, MD, MPH Ileana L. Pina, MD Stuart J. Pocock, PhD Jeffrey J. Popma, MD Francesco Prati, MD Matthew J. Price, MD Sunil V. Rao, MD Vivek Y. Reddy, MD Simon Redwood, MD Evelyn S. Regar, MD, PhD Bernhard Reimers, MD Charanjit S. Rihal, MD Krishna J. Rocha-Singh, MD Ivan C. Rokos, MD Manel Sabate, MD, PhD Dierk Scheinert, MD Bruno Scheller, MD Joachim Schofer, MD Peter A. Schneider, MD Allan Schwartz, MD Warren Sherman, MD Georgios Sianos, MD, PhD Horst Sievert, MD, PhD Ulrich Sigwart, MD Daniel I. Simon, MD Paul A. Sobotka, MD Paul Sorajja, MD Martina Kelly Speight, RN, BSN H. Robert Superko, MD Wilson Y. Szeto, MD David Taggart, MD, PhD Guillermo Tearney, MD, PhD Holger Thiele, MD Martyn R. Thomas, MD Craig A. Thompson, MD, MMSc Vinod H. Thourani, MD Leif Thuesen, MD Henry H. Ting, MD, MBA Jonathan M. Tobis, MD Zoltan G. Turi, MD E. Murat Tuzcu, MD Alec Vahanian, MD Marco Valgimigli, MD Nicolas M. van Mieghem, MD Stefan Verheye, MD, PhD Ron Waksman, MD Thomas Walther, MD Gerald S. Werner, MD, PhD Janet F. Wyman, MSN, ACNS-BC R. Michael Wyman, MD Paul Yock, MD Christopher K. Zarins, MD Thomas Zeller, MD Bram D. Zuckerman, MD Organizational Committee Andrea Abizaid, MD, PhD Fernando Alfonso, MD, PhD Yele Aluko, MD Somjot S. Brar, MD Stephen Balter, PhD Antonio L. Bartorelli, MD Lee N. Benson, MD Elchanan Bruckheimer, MBBS Joseph Carrozza, MD Christina A. Chadwick, RN, MSN David J. Cohen, MD Michael B. Collins, MD Joseph S. Coselli, MD Nick Curzen, PhD Tony Das, MD Anthony N. DeMaria, MD Tony J. DeMartini, MD Simon R. Dixon, MBChB John S. Douglas Jr, MD Andrejs Erglis, MD, PhD Michael E. Farkouh, MD, MSc Frederick Feit, MD Eulogio J. Garcia, MD 8

11 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics Ulrich Gerckens, MD Cindy L. Grines, MD Jonathan L. Halperin, MD Howard C. Herrmann, MD James B. Hermiller Jr, MD Richard R. Heuser, MD John McB. Hodgson, MD Leo Nelson Hopkins, MD Kurt Huber, MD Alice K. Jacobs, MD Sanjit S. Jolly, MD David E. Kandzari, MD Adnan Kastrati, MD Osamu Katoh, MD Spencer B. King III, MD Neal S. Kleiman, MD Bon-Kwon Koo, MD, PhD Edward M. Kreps, MD Frederick Kushner, MD Alexandra J. Lansky, MD Glenn N. Levine, MD Scott Lim, MD Brij Maini, MD Raj Makkar, MD Tift Mann, MD Steven P. Marso, MD Doff B. McElhinney, MD Margaret B. McEntegart, MD D. Christopher Metzger, MD Philip M. Meyers, MD Issam D. Moussa, MD Srihari S. Naidu, MD Patrick T. O Gara, MD Sahil A. Parikh, MD Manesh R. Patel, MD Anna Sonia Petronio, MD Mahmood K. Razavi, MD John F. Rhodes, MD David G. Rizik, MD Josep Rodes-Cabau, MD Lowell F. Satler, MD Binoy K. Singh, MD A.J. Conrad Smith, MD Thomas D. Stuckey, MD Jennifer A. Tremmel, MD Etsuo Tsuchikane, MD, PhD Frans van der Werf, MD Clemens von Birgelen, MD, PhD Bonnie H. Weiner, MD, MSEC David O. Williams, MD Bernhard Witzenbichler, MD 9

12 Associations and Affiliations Advanced Cardiovascular Solutions in Partnership with TCT American Association for Thoracic Surgery American College of Cardiology Angioplasty Summit-TCTAP 2013 ASEAN Federation of Cardiology Association on Cardiovascular Interventions of the Polish Cardiac Society Belgian Working Group of Interventional Cardiology Brazilian Society of Cardiology Brazilian Society of Hemodynamics and Interventional Cardiology Brazilian Society of Interventional Cardiology British Cardiovascular Intervention Society Canadian Association of Interventional Cardiology Cardiac Society of Australia and New Zealand Cardiology Society of India Cardiovascular Intervention Association of Thailand Cardiovascular Research Foundation China Interventional Therapeutics (CIT) 2013 in Partnership with TCT Chinese Society of Cardiology Circulation: Cardiovascular Interventions Colegio Argentino de Cardioangiologia Intervencionista Croatia Working Group of Interventional Cardiology, Croatian Cardiac Society Cyprus Society of Cardiology Czech Working Group of Interventional Cardiology of the Czech Society of Cardiology Danish Group of Interventional Cardiology Doctrina Med Dutch Society of Interventional Cardiology Dutch Working Group on Interventional Cardiology Egyptian Society of Cardiology Finland Working Group on Interventional Cardiology German Working Group of Interventional Cardiology Global Summit on Innovations in Interventions (GI2) at SOLACI/SBHCI 2013 in Partnership with TCT Greece Working Group on Interventional Cardiology Heart Association of Thailand Under the Royal Patronage of His Majesty the King Hellenic Cardiological Society Icelandic Society of Cardiology Innovations in Cardiovascular Interventions International Society of Endovascular Specialists International Symposium on Endovascular Therapy Interventional Cardiology Society of Mexico Interventional Council of the Cardiac Society of Australia and New Zealand Interventions of the Polish Cardiac Society Iran Heart Association Iranian Society of Interventional Cardiology Israeli Working Group on Interventional Cardiology/The Israel Heart Society Italian Society of Cardiology Invasive and Intervention Italian Society of Invasive Cardiology Japanese Association of Cardiovascular Intervention and Therapeutics Joint Interventional Meeting (JIM) 2013 Journal of the American College of Cardiology Korean Society of Cardiology Malaysian Interventional Cardiology Society Mexican Society of Cardiology Morocco Working Group on Interventional Cardiology Nordic-Baltic Study Group of Interventional Cardiology p-c-i live in Partnership with TCT Pediatric Interventional Cardiac Symposium Polish Cardiac Society: Association of Cardiovascular Interventions Preventive Cardiovascular Nurses Association Russian Society of Endovascular Surgery Russian Society of Interventional Cardiology and Angiology Saudi Arabia Cardiology Interventional Group Science Innovation Synergy Singapore Cardiac Society Sociedad de Cardiologia Intervencionista de Mexico Sociedad Latino Americana de Cardiologia Intervencionista Society for Cardiovascular Angiography and Interventions Society of Invasive Cardiovascular Professionals Spanish Society of Angiology and Vascular Surgery Spanish Working Group on Interventional Cardiology Stanford Biodesign Swedish Working Group on Coronary Heart Disease Swedish Working Group on PCI/ Swedish Society of Cardiology Swiss Society of Cardiology Taiwan Society of Cardiovascular Interventions Taiwan Transcatheter Therapeutics TCT Mediterranean TCT Russia TCT at Taiwan Transcatheter Therapeutics Turkish Association of PCI Turkish Society of Cardiology Victory Project Congressi Working Group on Interventional Cardiology and Acute Coronary Syndrome/Swiss Society of Cardiology Working Group on Interventional Cardiology of the Austrian Society of Cardiology Working Group on PCI, Danish Society of Cardiology Dutch Society of Interventional Cardiology Working Group on PCI, Swedish Society of Cardiology 10

13 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics TCT International Advisory Committee Argentina Ernesto M. Torresani, MD Australia and New Zealand James Cameron, MD Belgium Glenn Van Langenhove, MD, PhD Brazil Alexandre Abizaid, MD Canada Michael Love, MD Chile Oscar A. Mendiz, MD China Dayi Hu, MD Croatia Aleksander Ernst, MD Cyprus Petros Agathangelou, MD Czech Republic Petr Widimsky, MD, PhD Denmark Søren Galatius, MD Egypt Mohamed Sobhy, MD Europe Jean Fajadet, MD Finland Hannu Romppanen, MD Greece Georgios Parcharidis, MD Iceland Thorarinn Gudnason, MD, PhD India Ashok Seth, MD Iran Mahmood Hashemian, MD Israel Ran Kornowski, MD Italy Alberto Cremonesi, MD Japan Takeshi Kimura, MD Latin America Oscar A. Mendiz, MD Malaysia Rosli Mod Ali, MD Mexico Joel Estrada Gallegos, MD Netherlands Jan J. Piek, MD Poland Dariusz Dudek, MD Russia Bagrat G. Alekyan, MD Saudi Arabia Mohammed Balghith, MD Serbia Milan Nedeljkovic, MD Singapore Bernard Kwok, MD South Korea Jae Eun Jun, MD Spain Francisco Javier Goicolea Ruigómez, MD Sweden Göran Olivecrona, MD Switzerland Christoph Kaiser, MD Taiwan Jun-Jack Cheng, MD Thailand Sarana Boonbaichaiyapruck, MD Turkey Omer Goktekin, MD United Kingdom Simon Redwood, MD 11

14 Acknowledgements The TCT program development and organization is a year-round effort. Many people play important roles that ensure the success of TCT by contributing their experience and expertise. The Cardiovascular Greg Simsic Consultant Marketing and Creative Services Denise Tong Project Coordinator CME Program Development Sharwat Jahan Jaclyn Jacobson Elena Konovalova Laura LaSalle Wangyue Liu Mitchel Lustre Research Foundation wishes to give special thanks to all those who have worked tirelessly and with Scott Allan Wallick Senior Copy Editor Editorial Services Katharine Lymberis Sujatha Menon Catalin Mindrescu great dedication to our mission. Margaret Zetts Senior Program Coordinator CME Program Development Gary S. Mintz, MD Gopinathan Mohan Sophia Papamitrou Management Team Johnnie White, CMP Executive Director CRF Center for Education Stephen Cannarelli Senior Design Manager Marketing and Creative Services Jeff Chamlee Multimedia Manager Marketing and Creative Services Irma Damhuis Director External Relations Christina DiFrancesco Senior Coordinator, Grants Industry Relations Stephanie Gutch Manager, Operations and Content Web Sites Katie Herrion Senior Associate Industry Relations Guadalupe Hogarty, CMP Meeting Manager Meetings and Conventions Senior Management Group William A. Himmelsbach, MPH, FACHE President and Chief Executive Officer Matthew P. Pazaryna Chief Financial Officer Donald L. Abrams, Esq General Counsel Johnnie White, CMP Executive Director CRF Center for Education Helen Parise, ScD Nicoleta Pavlovici Khary Perry Ecaterina Prepelita Antonio Pullano Saira Punjwani Eugene Salgado Raquel Sanchez Lena Slawitsky Christina Tien Shawnalee Vassell Stephanie Wolin Douey Wright Ke Xu Josh Hartman Director Educational Services and Strategic Relations Jason Kahn Manager, Academic Content Editorial Services Fun Lee, CMP Director Meetings and Conventions Ted Silverstein Director Marketing and Creative Services Todd Wagner Manager, Print Production Marketing and Creative Services Colleen Whelan Director CME Program Development Planning Group Elizabeth Burke Executive Assistant CRF Center for Education Caitlin C. Cox Senior Medical Writer/Editor Editorial Services Kim Dalton Medical Writer/Editor Editorial Services Alexander Damhuis CME Coordinator Michael Houk Multimedia Designer Marketing and Creative Services Yael L. Maxwell Medical Writer/Editor Editorial Services Laura A. McKeown Medical Writer/Editor Editorial Services Lilian Moreira Associate Project Manager Marketing and Creative Services Thomas Mortimer Proofreader Editorial Services Leonard Posso Graphic Designer Marketing and Creative Services Tricia Rawh Program Project Manager Industry Relations Abby Rees Program Coordinator CME Program Development Diana Sanchez Junior Graphic Designer Marketing and Creative Services Adam Saunders E-Marketing and Customer Service Coordinator Web Sites Administrative Support Staff Kelly Clyde Nancy Collins Robin Dennis Gabriella Gallo-Cisak Ruth Mansueto Diane Salerno-Madrid CRF Clinical Trials Center Maria Alfonso Sonia Burgher Isabel Corral Ecaterina Cristea Rosa De Jesus Ossen Delbrun Marina Dizik Champika Djurkovic Ovidiu Dressler Monica Embacher Martin Fahy Dominic Francese Philippe Genereux, MD Christopher Grady Alejandra Guerchicoff Cecilia Jade Hart Raza Hijazi Irene Hueter Stephen Iacono Finance Yuliya Bogomolny Arlene Brown Jenni Kong Eileen Morales Cheryl Turnbull Human Resources Kelli O Toole Emilia K. Valtcheva Office Services Aryel Flores De Valgaz Information Technology Louis Cruz Richard Han Alain Moise Kapil Nayyar External Relations Irma Damhuis Judy Romero Office of Legal Affairs Donald L. Abrams, Esq 12 CME Program Development

15 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics Quality Assurance Whitney Petrie Maria Rossolino Garreth Sharp CRF Skirball Research Center Leslie Anglin Yan-Ping Cheng Gerard B. Conditt Adrienne Dardenne, DVM Duane Dennis Juan F. Granada, MD Anguo Gu Jaime Guzman Greg L. Kaluza, MD, PhD Patricia Madlinger Jennifer McGregor Patricia Mount Athanasios Peppas Jodi Robinholt Armando Tellez, MD Kathy Troyan Alyssa Wagner Kimberly White Geng-Hua Yi CRF Fellows Tomotaka Dohi, MD Liang Dong, MD Nobuaki Kobayashi, MD Seung Jin Oh, MD Takehisa Simizu, MD Lin Wang, MD Mayank Yadav, MD Jong Shiuan Yeh, MD Board of Directors of the Cardiovascular Research Foundation Eric B. Woldenberg, Esq Chair William A. Himmelsbach, MPH, FACHE President and Chief Executive Officer Joseph G. Beck Colette Y. Gardner Robert L. Glenning Jeffrey W. Moses, MD Arthur J. Pergament Eric A. Rose, MD Marvin L. Woodall Patricia Woods, PhD 13

16 Acknowledgements Columbia University Medical Center Faculty Mark A. Apfelbaum, MD Michael B. Collins, MD Braulio Flores, MD Alexander Gorodnitskiy, MD William A. Gray, MD Rebecca Hahn, MD Nellie Kalcheva, MD Ajay J. Kirtane, MD, SM Susheel Kodali, MD Edward M. Kreps, MD Martin B. Leon, MD Jeffrey W. Moses, MD Manish Parikh, MD LeRoy E. Rabbani, MD Norbert Rainford, MD Abdollah Sedighi, MD Warren Sherman, MD Robert J. Sommer, MD Gregg W. Stone, MD Giora Weisz, MD Mathew Williams, MD Clinical Instructors Kishore J. Harjai, MD Vishal Kapur, MD Omar Khalique, MD Farhan Khawaja, MD Jorge Magallon, MD Jean-Michel Paradis, MD Fellows Hemal Gada, MD Philip Green, MD Kendra Grubb, MD Tamim Nazif, MD Torsten Vahl, MD Clinical Staff Wilson Arango, FNP-BC Marian C. Hawkey, RN Hilary Nierenberg, NP, MPH Jessica Forman, RPA-C Administrative Staff Regina Amelko C. Jeanette Bermeo Donna Brown Teri FitzGerald Rosie Calcano Yemilet Gonzalez Stacy Hall Suzanne Jakubiak Rona Kahn AnnMarie Kelly Eileen Madison Erika Marrero Enid Montalvo Dora Mussenden Jessica Ramirez Jacqueline Rosenthal Tiesha Ruiz Diane Salerno-Madrid Joann Serrano Annicia Thomas Samantha Tsiolis Aja Washington Viktoriya Yakhyaeva Clinical Research Staff Alejandro Aramburu, BA Andy Morales, MD Angeli Feri, BS Angelica Castaneda, BS Ashlee Mattone, BS Autumn Austin, BA, MPH Ben Lerman, BS Diane Weber, BA Diaa Hakim, MD, PHD Eric Adegbite, BS Eunice Dilone Fernando Sosa, BS Joyce Ann Thomas, BS Kate Dalton, MS, RD Luz Jaquez, BS Lauren Privitera, MPH Matthew Brinkman, MS Rosa Lazarte, MD Treena Williams, BE Vasiliki Chantziara, MD Yasir Qureshi, MD Cath Lab Aabrana Evans, RCIS Alex Castillo, RT Alla Ogii-Landis, RN Andrew Stefanski, RT Anne Rose Ermita, RN Annelle Williams Araceli Limbaga, RN Barbara Stock, RN Beatriz Custodio Benny Joseph, RN Betty Yu-Chong, RN Brian Aquino, RN Brian Padilla Byron Johnson Cheery de Padua, RN Christine Carthy, RN Christopher Bechtel, RCIS Claudia Echeverry, RCIS Danielle Thompson Darlene Wise, RN David Borsh, RN Debbie Donaldson Debbie Maccaro Deborah Plant, RN Deirdre Conlon, RN Delita Glori-Feri, RN Denise Groff, RN Dennis Sta. Maria, RN Derrick Horne, RN Dionysius Tejero, RN Edelmira Quintero Ellen Moreno, RN Ellen Pitiger, RN Emil Osorno, RN Errol Ellis Eufemia Penaflor, RN Evaine Iral-Fallurin, RN Felicia Leon Fely Ballongay, RN Gerard Cowles, RN Gina Uy, RN Gleonisi Ramirez Harold Stella Hilda Devlin, RN Holly McCall, RN Hongge Wei, RCIS Ingrid Lora Isidro Gonzalez Jaime Crist, RN Jan Greenfield, RN Jaysen Hernandez, RCIS Jhan Nunez Joanna Castro, RT Jodi Conway, RN Joel De Jesus Justine Wee-Boac, RN Kathleen Casey, RN Kelly Brocker, RN Kelly Light, RN Ketevan Telia Khady Fall Kristin Fagerlin, RCIS Laura Thomas, RN Lenny Guzman, RT Leslyn Hall Lihua Fang, RCIS Louella Galarpe Danao, RN Louis Lopez Lu Kan Gorman RN Margaret Griffin, RN Maria Antonio, RN Maria Bernardez, RN Maria Damayo-Medina, RN Maria Lourdes Tan-Uy, RN Maria Mamuri, RN Maria Younessian, RN Maricar Jordana, RN Mary Egan, RN Mary Ellen Morgan, RN Melanie Diaz, RN Melissa Pusterla, RN Michael De Leon, RN Michael Guiry, RPA-C Michael Sgarella, RCIS Michele Foley, RN Michelle Lindquist, RN Michelle Murray, RN Michelle Rodriguez, RN Michelle Tan, RN Miriam Candaroma, RN Moira Smith, RN Myriam Medrano Nenita Generales, RN Nina Editha Pajimna, RN Noel Castor, RN Norma Ennis Osama Amine, RCIS Patrick Hayford Patrick Kline, RN Paul Kelley, RN Phyllis Rodriguez Regel Del Mundo, RN Rene Ambrona Rodello Diamante Ronald Rigor, RN Rose Ang, RN Rosemary Valencia, RN Sandra Smith Serge Sabo, RCIS Sheehan Raab, RT, RCIS Sheri Pinto, RN Siobhan Reilly, RN Soojin Horland, RN Stephanie Quach Luc, RN Stephen Balter, PhD Tamara Grazette, RN Tammy Van Gelder, RCIS Viola King Vivian Tamara, RN, RCIS Wayne Clarke Woodley Perpignan, RN Yuan Fang, RCIS Yovana Chardon Yvette Reyes Zoraya Boissard Physician Assistants Alicia Adams, RPA-C Sean Ahearn, RPA-C Anna Akker, RPA-C Gretchen Andersen, RPA-C Michael Bergman, RPA-C Mario Buss, RPA-C Kamman Chan, RPA-C Tara Collins, RPA-C Pilar Dolcimascolo, RPA-C Galina Dumchin, RPA-C 14

17 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics Marian Elbert, RPA-C Neisha Hariprashad, RPA-C Seing Houy, RPA-C Daria Jilinskaia, RPA-C Melissa Katzman, RPA-C Nancy Copeland-Kelley, RPA-C Simon Krivor, RPA-C Brittany Macdonald, RPA-C Kristin Pasquarello, RPA-C Irina Pilosova, RPA-C Michael Querijero, RPA-C Eileen Redmond, RPA-C Sofia Romero, RPA-C Madeline Seergy, RPA-C Jamie Shein, RPA-C Yana Smolyaninova, RPA-C Mindy Sporn, RPA-C Cheri Tomasino, RPA-C Bethany West, RPA-C Columbia Heart Valve Center Faculty Michael Argenziano, MD Emile Bacha, MD William A. Gray, MD Rebecca T. Hahn, MD Susheel Kodali, MD Martin B. Leon, MD Allan Schwartz, MD Craig R. Smith, MD Mathew R. Williams, MD Clinical Staff Isaac George, MD Kendra Grubb, MD Russell A. Brandwein, RPA-C Tiffany Wong, RPA-C Fellows and Clinical Instructors Jean-Michel Paradis, MD Omar Khalique, MD Tamin Nazif, MD Kishore Harjai, MD Philip Green, MD Administrative Staff Maria Alu Diane Amato Larry Beilis Julie Feliz Julie Fisher Charlette Gomez Lisa Hathaway Stella Rona Kahn Patricia E. Knipper, RN Marilyn Noda Braydon Pace Alina Sokolinskaya Research Team Elizeth Brito Vasiliki Chantziara Kate Dalton Marian C. Hawkey, RN Ben Lerman Dawn Scott, RN Jeanie Sohn 15

18 acknowledgements Abstract Reviewers The TCT Course Directors and the Abstract Selection Committee, chaired by Gary S. Mintz, MD, wish to express their sincere appreciation to the physicians who selflessly donated their time and expertise as TCT Abstract Reviewers. Abstract Selection Committee Chair: Gary S. Mintz, MD Joseph D. Babb, MD Charles E. Chambers, MD Philippe Généreux, MD William A. Gray, MD Ajay J. Kirtane, MD, SM Lloyd Klein, MD TCT Abstract Reviewers Alexandre Abizaid, MD Alex Abou-Chebl, MD William Abraham, MD David H. Adams, MD Tayo Addo, MD Takashi Akasaka, MD Fernando Alfonso, MD Steven Lee Almany, MD John Ambrose, MD Zahid Amin, MD Max Amor, MD Dominick Angiolillo, MD Brian H. Annex, MD Gary Ansel, MD David Antoniucci, MD Robert Applegate, MD Constantine Aroney, MD Herbert Aronow, MD Yasushi Asakura, MD Emile Bacha, MD Shmuel Banai, MD Sripal Bangalore, MD Adrian Banning, MD Gerald Barbeau, MD Antonio Bartorelli, MD Jozef Bartunek, MD Theodore Bass, MD Eric R. Bates, MD Jeroen Bax, MD Kevin Beatt, PhD Jorge Belardi, MD Lee Benson, MD Nirat Beohar, MD Daniel Berman, MD Olivier François Bertrand, MD Rafael Beyar, MD Giancarlo Biamino, MD Giuseppe Biondi Zoccai, MD John Bittl, MD James Blankenship, MD Steven Bolling, MD Raoul Bonan, MD Johannes Bonatti, MD Laurent Bonello, MD Roberto Botelho, PhD Bruce Bowers, MD Somjot Brar, MD Stephen Brecker, MD Sorin Brener, MD Carlo Briguori, MD Emmanouil Brilakis, MD Ralph Brindis, MD Elchanan Bruckheimer, MBBS Maurice Buchbinder, MD Lutz Buellesfeld, MD Jacques Busquet, MD Pawel E. Buszman, MD Robert Byrne, MBBCh Adriano Caixeta, MD Louis Cannon, MD Davide Capodanno, MD Ronald Caputo, MD John Carroll, MD Joseph Carrozza Jr, MD Graham Anthony Cassel, MD Charles E. Chambers, MD Charles Chan, MD John Cheatham, MD Shao Liang Chen, MD YunDai Chen, PhD James Chesebro, MD Bernard Chevalier, MD Alaide Chieffo, MD Kenneth Chin, MD Nicolas Chronos, MD David Cohen, MD Eric Cohen, MD Marc Cohen, MD Mauricio G. Cohen, MD Tyrone Collins, MD Antonio Colombo, MD Anthony Comerota, MD Jose Condado, MD Marco Costa, MD Ricardo A. Costa, MD Jose Costa Jr, MD Michael Cowley, MD David Cox, MD Alain G. Cribier, MD Fernando Cura, MD Nick Curzen, PhD Donald Cutlip, MD Joost Daemen, MD Jason Daiger, MD Haim Danenberg, MD George D. Dangas, MD, PhD Debabrata Dash, MD Harold Dauerman, MD Charles Davidson, MD Justin Davies, PhD Adam de Belder, MD Mark de Belder, MD Jose M. De la Torre Hernandez, MD Giuseppe De Luca, MD Robbert J. de Winter, MD Larry Dean, MD Anthony DeMaria, MD Tony DeMartini, MD Carlo Di Mario, MD Germano Di Sciascio, MD Vasken Dilsizian, MD Stefanie Dimmeler, PhD Simon Dixon, MBChB Ozgen Dogan, MD Henricus Duckers, MD Dariusz Dudek, MD Vladimír Džavík, MD Adrian Ebner, MD Neal Eigler, MD Stephen Ellis, MD Andrejs Erglis, MD Michael Ezekowitz, MD Jean Fajadet, MD Michael Farkouh, MD David Faxon, MD William Fearon, MD Frederick Feit, MD Marc Feldman, MD Ted Feldman, MD Francisco Fernandez-Aviles, MD Michael A. Fifer, MD Tim Fischell, MD John Flack, MD Nicolas Foin, PhD Olaf Franzen, MD William J. French, MD Alfredo Galassi, MD Daljeet S. Gambhir, MD James Gammie, MD Ripal Gandhi, MD Run-Lin Gao, MD Eulogio Jesus Garcia, MD Lawrence Garcia, MD Hector M. Garcia-Garcia, MD Efrain Gaxiola, MD Junbo Ge, MD Philippe Genereux, MD Isaac George, MD Ulrich J. Gerckens, MD Bernard J. Gersh, MBChB Anthony Gershlick, MD Gary Gershony, MD C. Michael Gibson, MD Ian C. Gilchrist, MD Robert Giugliano, MD Dietmar Glogar, MD Sheldon Goldberg, MD Steven Goldberg, MD Mark Goldberger, MD James Goldstein, MD Juan F. Granada, MD Christopher Granger, MD J. Aaron Grantham, MD William A. Gray, MD Paul Grayburn, MD Cindy Grines, MD Liliana Grinfeld, MD Luis Gruberg, MD Giulio Guagliumi, MD Victor Guetta, MD Vivek Gupta, MD Paul A. Gurbel, MD Lee Guterman, MD Luis Guzman, MD Alison Halliday, MS Michalis Hamilos, MD Christian Hamm, MD Yaling Han, MD Kishore Harjai, MD Robert Harrington, MD Michael Haude, MD Jose P.S. Henriques, MD Michel Henry, MD Timothy D. Henry, MD Richard Heuser, MD Ziyad Hijazi, MD David Hildick-Smith, MD Jonathan Hill, MD David Holmes Jr, MD Yasuhiro Honda, MD Myeong-Ki Hong, MD Eric Horlick, MD Angela Hoye, MD Dayi Hu, MD Kurt Huber, MD Ioannis (John) Iakovou, MD Thomas Ischinger, MD Alice Jacobs, MD Michael Jaff, DO Allan Jaffe, MD Farouc Jaffer, MD Ik-Kyung Jang, MD Lisette Okkels Jensen, MD Allen Jeremias, MD Sanjit Jolly, MD Michael Joner, MD Petr Kala, MD Anne Kaltoft, MD Greg L. Kaluza, MD, PhD 16

19 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics David Kandzari, MD Soo-Jin Kang, MD Paul Hsien-Li Kao, MD Samir Kapadia, MD Aaron Kaplan, MD A. Pieter Kappetein, MD Saibal Kar, MD Dimitri Karmpaliotis, MD Adnan Kastrati, MD Upendra Kaul, MD Zaza Kavteladze, MD Elvin Kedhi, MD Henning Kelbaek, MD Dean Kereiakes, MD Morton Kern, MD R. Stefan Kiesz, MD Hyo-Soo Kim, MD Young-Hak Kim, MD Takeshi Kimura, MD Spencer King III, MD Ajay J. Kirtane, MD, SM Neal Kleiman, MD Susheel Kodali, MD Raghu Kolluri, MD David Kong, MD Bon-Kwon Koo, MD Jacques Koolen, MD Ran Kornowski, MD Zvonimir Krajcer, MD Paul Kramer, MD Hans Krankenberg, MD Takashi Kubo, MD Karl-Heinz Kuck, MD Sreenivas Kumar, MD Jean-Claude Laborde, MD Roger Laham, MD Rudiger Lange, MD Alexandra J. Lansky, MD John Lasala, MD Jens Flensted Lassen, MDA Zeem Latib, MD Michel Le May, MD Guy LeClerc, MD Michael Lee, MD Massoud Leesar, MD Thierry Lefevre, MD Pedro Lemos, MD Martin B. Leon, MD Norman Lepor, MD Amir Lerman, MD Michael Lim, MD Scott Lim, MD Thosaphol Limpijankit, MD A. Michael Lincoff, MD JoAnn Lindenfeld, MD Italo Linfante, MD William Lombardi, MD Hugo Londero, MD Robert Lookstein, MD Chaim Lotan, MD Yves Louvard, MD Michael P. Love, MD Reginald I. Low, MD Sumaira Macdonald, MD Lindsay Machan, MD Michael J. Mack, MD Akiko Maehara, MD Brij Maini, MD Francesco Maisano, MD Ganesh Manoharan, MD Steven Manoukian, MD Steven Marso, MD Detlef Mathey, MD Klaus Mathias, MD Jon Matsumura, MD Luiz Mattos, MD Daniel J. McCormick, DO Doff McElhinney, MD Margaret B. McEntegart, MD Thomas McNamara, MD John McPherson, MD Julinda Mehilli, MD Roxana Mehran, MD Shamir Mehta, MD Bernhard Meier, MD Oscar Mendiz, MD Maurizio Menichelli, MD Ian T. Meredith, PhD D. Christopher Metzger, MD Philip Meyers, MD James Min, MD Erich Minar, MD Gary S. Mintz, MD Greg Mishkel, MD Neil Moat, MD David J. Moliterno, MD Michael Mooney, MD Pedro Moreno, MD Marie-Claude Morice, MD Issam Moussa, MD Michael Mullen, MD David W.M. Muller, MD Brad Munt, MD Toshiya Muramatsu, MD Christoph Naber, MD Sherif F. Nagueh, MD Srihari S. Naidu, MD Masato Nakamura, MD Sunao Nakamura, MD Brahmajee Nallamothu, MD Massimo Napodano, MD Kenya Nasu, MD Gjin Ndrepepa, MD Franz-Josef Neumann, MD Christoph A. Nienaber, MD Eugenia Nikolsky, MD Michelle O Donoghue, MD Patrick O Gara, MD William O Neill, MD Andrzej Ochala, MD Masahiko Ochiai, MD Takao Ohki, MD Keith G. Oldroyd, MD Jeffrey Olin, DO Eustaquio Maria Onorato, MD John A. Ormiston, MD Miodrag Ostojic, MD Igor Palacios, MD Tullio Palmerini, MD Manotosh Panja, MD Keyur Parikh, MD Sahil Parikh, MD Duk-Woo Park, MD Seung-Jung Park, MD Juan Parodi, MD Amit Patel, MD Manesh Patel, MD Tejas Patel, MD Constantino Pena, MD Marc Penn, MD Anna Sonia Petronio, MD Nicolo Piazza, MD Augusto Pichard, MD Jan Piek, MD Nico Pijls, MD Ileana Piña, MD Duane Pinto, MD Jeffrey Popma, MD Francesco Prati, MD Matthew Price, MD Ramon Quesada, MD LeRoy Rabbani, MD Lorenz Räber, MD Afzalur Rahman, MD Sunil Rao, MD Sudhir Rathore, MD Mahmood Razavi, MD Michael J. Reardon, MD Rita F. Redberg, MD Simon Redwood, MD Evelyn Regar, MD Bernhard Reimers, MD Expedito Ribeiro, MD Charanjit Rihal, MD Michael Rinaldi, MD Stéphane Rinfret, MD David Rizik, MD Josep Rodes-Cabau, MD Alfredo Rodriguez, MD Matthew Roe, MD Jason Rogers, MD Kenneth Rosenfield, MD Mohd Ali Rosli, MD Carlos E. Ruiz, MD Manel Sabate, MD Robert Safian, MD Shigeru Saito, MD Luigi Salemme, MD Habib Samady, MD Shaun Samuels, MD Giuseppe Sangiorgi, MD Maurice Sarano, MD Gary Schaer, MD Robert M. Schainfeld, DO Erick Schampaert, MD Bruno Scheller, MD Peter A. Schneider, MD Paul Schoenhagen, MD Joachim Schofer, MD Gerhard Schuler, MD Allan Schwartz, MD Robert S. Schwartz, MD Amit Segev, MD Patrick Serruys, MD Ashok Seth, DSc Samin Sharma, MD Warren Sherman, MD Thomas M. Shimshak, MD Mehdi Shishehbor, DO Georgios Sianos, MD Dirk Sibbing, MD Peter Sick, MD Horst Sievert, MD Ulrich Sigwart, MD Frank Silvestry, MD Daniel Simon, MD Varinder P. Singh, MD Kimberly Skelding, MD Marvin Slepian, MD Richard Smalling, MD Peter Smits, MD Mohamed Sobhy, MD Robert Sommer, MD Paul Sorajja, MD Konstantinos Spargias, MD Sack Stefan, MD Christodoulos Stefanadis, MD Philippe Gabriel Steg, MD Terje Steigen, MD Pieter Stella, MD Peter Stone, MD Bradley Strauss, MD Thomas Stuckey, MD Rakesh Suri, MD Takahiko Suzuki, MD Corrado Tamburino, MD Huay Cheem Tan, MBBS Jean-François Tanguay, MD Gunnar Tepe, MD Holger Thiele, MD Martyn Thomas, MD Craig Thompson, MD 17

20 acknowledgements Vinod Thourani, MD Leif Thuesen, MD Jonathan Tobis, MD Pim A.L. Tonino, MD On Topaz, MD Konstantinos Toutouzas, MD Hendrik Treede, MD Jennifer Tremmel, MD Dietmar Trenk, PhD Etsuo Tsuchikane, MD Zoltan Turi, MD E. Murat Tuzcu, MD Philip Urban, MD Alec Vahanian, MD Marco Valgimigli, MD Frans Van de Werf, MD Glenn Van Langenhove, MD Nicolas M. Van Mieghem, MD Freek Verheugt, MD Stefan Verheye, MD George W. Vetrovec, MD Renu Virmani, MD Clemens von Birgelen, MD Szilard Voros, MD Pascal Vranckx, MD Marco Wainstein, MD Ron Waksman, MD Simon Walsh, MD Thomas Walther, MD Bonnie H. Weiner, MD William Weintraub, MD Neil Weissman, MD Giora Weisz, MD Peter Wenaweser, MD Gerald S. Werner, MD Grayson Wheatley, MD Brian Whisenant, MD Mark Wholey, MD Michael Wholey, MD Robert Wilensky, MD Jeffrey Williams, MD Mathew Williams, MD Stephan Windecker, MD Bernhard Witzenbichler, MD Stephen Wiviott, MD Jochen Wöhrle, MD Wojciech Wojakowski, MD S. Chiu Wong, MD Bo Xu, MD Steven Yakubov, MD Masahisa Yamane, MD Robert Yeh, MD Alan Yeung, MD Christopher Zarins, MD Andreas M. Zeiher, MD Thomas Zeller, MD Challenging Case Reviewers The Challenging Case Committee led by Alexandre Abizaid, MD, PhD, and the TCT Course Directors would like to express their gratitude to the physicians who provided time and expertise as Challenging Case Reviewers. Alexandre Abizaid, MD David Adams, MD S. Hinan Ahmed, MD Dominick Angiolillo, MD Steven Bailey, MD Eric R. Bates, MD Mark Bates, MD Jorge Belardi, MD Lee Benson, MD John Bittl, MD James Blankenship, MD Peter Block, MD Raoul Bonan, MD Emmanouil Brilakis, MD Jeffrey Brinker, MD Samuel Butman, MD Charles Chambers, MD Alaide Chieffo, MD Mehmet Cilingiroglu, MD Mauricio G. Cohen, MD Tyrone Collins, MD Antonio Colombo, MD Marco Costa, MD George D. Dangas, MD, PhD Charles Davidson, MD Carlo Di Mario, MD Douglas Drachman, MD David Faxon, MD Marc Feldman, MD Ted Feldman, MD Philippe Genereux, MD Ian C. Gilchrist, MD A. Marc Gillinov, MD Steven Goldberg, MD James Goldstein, MD Paul Grayburn, MD Eberhard Grube, MD Rebecca Hahn, MD James Hermiller Jr, MD Howard C. Herrmann, MD Richard Heuser, MD Ziyad Hijazi, MD John Hirshfeld, MD Michael Jaff, DO Allen Jeremias, MD Thomas Jones, MD Samir Kapadia, MD A. Pieter Kappetein, MD Navin Kumar Kapur, MD Saibal Kar, MD Adnan Kastrati, MD Morton Kern, MD Carey D. Kimmelstiel, MD Takeshi Kimura, MD Ran Kornowski, MD Zvonimir Krajcer, MD Karl-Heinz Kuck, MD Richard Lange, MD Massoud Leesar, MD Pedro Lemos, MD Scott Lim, MD Michael J. Mack, MD Francesco Maisano, MD Ganesh Manoharan, MD Roxana Mehran, MD Neil Moat, MD David J. Moliterno, MD Douglas Morrison, MD John A. Ormiston, MD Igor Palacios, MD Seung-Jung Park, MD Lynn Peng, MD Anna Sonia Petronio, MD Nicolo Piazza, MD Duane Pinto, MD Vivek Reddy, MD John Reilly, MD Mark Reisman, MD Josep Rodes-Cabau, MD Carlos E. Ruiz, MD Stefan Sack, MD Shigeru Saito, MD Elias Sanidas, MD Robert M. Schainfeld, DO Joachim Schofer, MD Gerhard Schuler, MD Allan Schwartz, MD Patrick Serruys, MD Ashok Seth, DSc Frank Silvestry, MD Martyn Thomas, MD Jonathan Tobis, MD On Topaz, MD Jennifer Tremmel, MD Thomas Tu, MD Zoltan Turi, MD E. Murat Tuzcu, MD Barry Uretsky, MD Nicolas van Mieghem, MD Thomas Walther, MD Bonnie H. Weiner, MD Brian Whisenant, MD Mathew Williams, MD Thomas Zeller, MD Late Breaking Trial and First Report Reviewers The TCT Course Directors, Martin B. Leon, MD, and Gregg W. Stone, MD, would like to thank the following physicians who provided their expert assistance in the selection process and who made the late breaking trial and first report investigation review process possible. Gary Ansel, MD Sorin Brener, MD Antonio Colombo, MD George D. Dangas, MD, PhD Michael Ezekowitz, MBChB Ted Feldman, MD Philippe Genereux, MD Bernard J. Gersh, MBChB C. Michael Gibson, MD Juan F. Granada, MD Liliana Grinfeld, MD Eberhard Grube, MD James Hermiller Jr, MD Ziyad Hijazi, MD David Hildick-Smith, MD David Holmes Jr, MD Alice Jacobs, MD A. Pieter Kappetein, MD Dean Kereiakes, MD Ajay J. Kirtane, MD, SM Susheel Kodali, MD Alexandra J. Lansky, MD Martin B. Leon, MD Chaim Lotan, MD Michael J. Mack, MD Akiko Maehara, MD Roxana Mehran, MD Oscar Mendiz, MD Ian T. Meredith, PhD David J. Moliterno, MD Masahiko Ochiai, MD Manish Parikh, MD Seung-Jung Park, MD LeRoy Rabbani, MD Stefan Sack, MD Ashok Seth, DSc Sigmund Silber, MD Gregg W. Stone, MD Corrado Tamburino, MD Giora Weisz, MD Harvey D. White, MD Mathew Williams, MD Stephan Windecker, MD 18

21 Commercial Support TCT 2012 is sponsored by the Cardiovascular Research Foundation and partially funded through educational grants from commercial supporters. The Cardiovascular Research Foundation strives to ensure that its programs are as educational as possible and free from bias. To support this endeavor, TCT directors and co-directors create organizational and scientific committees to assist in educational content development and content oversight for live cases, spotlight sessions, case reviews, practical workshops, and scientific symposia. These sessions are developed without influence from commercial supporters. The educational grant support of our industry colleagues, who, like the Cardiovascular Research Foundation, are dedicated to educating medical professionals and the public to enhance patient outcomes, helps to make each TCT possible. The Cardiovascular Research Foundation gratefully acknowledges the TCT 2012 MAJOR BENEFACTORS: Abbott Vascular Boston Scientific Corporation Cardiovascular Systems, Inc. Cordis Cardiac and Vascular Institute SM Edwards Lifesciences Gilead Sciences, Inc. Medtronic CardioVascular The Cardiovascular Research Foundation gratefully acknowledges the TCT 2012 BENEFACTORS: AstraZeneca Cook Medical St. Jude Medical, Inc. Terumo Medical Corporation The Medicines Company The Cardiovascular Research Foundation appreciates the educational grant support for TCT 2012 provided by: ACROSTAK Corporation AirStrip Technologies AngioScore, Inc. BIOTRONIK Baxter Healthcare Corporation BridgePoint Medical, Inc. CardioKinetix, Inc. CircuLite, Inc. Cytori Therapeutics Daiichi Sankyo, Inc. and Lilly USA LLC Direct Flow Medical, Inc. Eurocor GmbH HeartFlow, Inc. Lutonix/Bard Mesoblast, Ltd. STENTYS S.A. Thoratec Corporation Valtech Cardio, Ltd. W. L. Gore & Associates The Cardiovascular Research Foundation appreciates the educational grant support for the Faculty Support Program provided by: ABIOMED, Inc. AngioScore, Inc. BIOTRONIK Boston Scientific Corporation Cordis Cardiac and Vascular Institute SM Edwards Lifesciences MAQUET Cardiovascular Medtronic CardioVascular The Cardiovascular Research Foundation appreciates the educational grant support for TCT: An Integrated Course for Surgeons and Interventionalists provided by: Abbott Vascular Medtronic CardioVascular Thoratec Corporation The Cardiovascular Research Foundation appreciates the educational grant support for the 21st Annual Cardiovascular Nurse Technologist Symposium provided by: Disclosure Statement Abbott Vascular Boston Scientific Corporation Cordis Cardiac and Vascular Institute SM Medtronic CardioVascular St. Jude Medical, Inc. It is the policy of the Cardiovascular Research Foundation to ensure balance, independence, objectivity, and scientific rigor in all of its sponsored educational activities. Commercial support from industry does not influence educational content, faculty selection, and/or faculty presentations, and, therefore, does not compromise the scientific integrity of the educational activity. Discussion of off-label product usage and/or off-label product use during live cases is made at the sole discretion of the faculty. Off-label product discussion and usage are not endorsed by the Cardiovascular Research Foundation or the conference directors of this activity. Faculty participating in continuing medical education activities sponsored by the Cardiovascular Research Foundation are required to disclose to the activity audience any real or apparent conflicts of interest related to the content of their presentations. Faculty not complying with this policy are not permitted to participate in this activity. 19

22 special Activities Education Peer-Reviewed Oral, Poster, and Challenging Case Abstracts The presentation of original peer-reviewed research is the basis of scientific discovery, representing the heart of academic medicine and offering participants opportunities to interact with peers in an intimate setting for critical review prior to manuscript generation. To emphasize TCT s belief in the importance of such research, all accepted abstracts will be presented in a dedicated four-hour block. Abstracts, both poster and oral, will be downloadable during TCT in electronic format via TCTMD.com and from the cyber center stations located throughout the Miami Beach Convention Center. Abstracts are published in a special supplement of the Journal of the American College of Cardiology, available in the attendee meeting bag. New this year, the top oral abstracts will be available to view in an interactive format via ipads available outside the Main Arena. Challenging Case Video Presentations will be available during the Poster Abstract Sessions and also on Wednesday and Thursday. Please see pages for complete listings or visit Tuesday, October 23 Poster Abstract and Challenging Case Video Presentations 8:00 am-10:00 am Oral Abstract Sessions 10:30 am-12:30 pm Wednesday and Thursday, October Top Oral and Poster Abstracts ipad Display 8:00 am-6:00 pm Challenging Case Video Presentations 10:00 am-11:00 am, 2:00 pm-3:00 pm The top poster abstracts will be moved to the Exhibit Hall and available for viewing during Exhibit Hall hours. 3-D Theater New at TCT you can experience full 3-D demonstrations of present and future technologies for structural heart disease using 3-D technology. The new 3-D Theater will host video vignettes focused on demonstrations of aortic and mitral valve anatomies. A special dedicated edited taped case will present a novel technology in the 3-D Theater, 3-D Interventional Cardiovascular Procedure, on Wednesday, October 24, from 1:30 pm-2:00 pm. The 3-D Theater is located in the Physician Training Center inside the Exhibit Hall of the Miami Beach Convention Center. Tuesday, October 23 3-D 30-Minute Vignettes 1:30 pm - 3-D Aortic Valve 2:30 pm - 3-D Mitral Valve 3:30 pm - 3-D Potpourri of Anatomies 4:30 pm - 3-D Aortic Valve Wednesday, October 24 3-D 30-Minute Vignettes 9:30 am - 3-D Aortic Valve 10:30 am - 3-D Mitral Valve 11:30 am - 3-D Potpourri of Anatomies 2:30 pm - 3-D Aortic Valve 3:30 pm - 3-D Mitral Valve 4:30 pm - 3-D Potpourri of Anatomies Thursday, October 25 3-D 30-Minute Vignettes 9:30 am - 3-D Aortic Valve 10:30 am - 3-D Mitral Valve 11:30 am - 3-D Potpourri of Anatomies 1:30 pm - 3-D Aortic Valve 2:30 pm - 3-D Mitral Valve 3:30 pm - 3-D Potpourri of Anatomies 4:30 pm - 3-D Aortic Valve International Multiplex Theater Challenging case presentations will be highlighted in the new International Multiplex Theater with two society-sponsored Challenging Case Theaters offering sessions organized under the auspices of numerous societies from around the world. The International Multiplex Theater is located in Hall A of Miami Beach Convention Center. Please see pages 118 and 138 for complete listings or visit ACC Educational Sessions Co-sponsored by the American College of Cardiology (ACC) and the Cardiovascular Research Foundation (CRF) These sessions will be planned and developed by the ACC in partnership with CRF. Tuesday, October 23 1:00 pm-6:00 pm Hot Topics in Cardiology: ACC.12 with TCT Highlights for the Interventional, Invasive, and General Cardiologist (page 107) Launching and Sustaining Your Career: A Joint Session of the ACC s Cardiovascular Leadership (page 109) Wednesday, October 24 12:15 pm-1:45 pm ACC Special Fellows Session I. Valvular Heart Disease: Year in Review 2012 (page 125) Thursday, October 25 12:15 pm-1:45 pm ACC Special Fellows Session II. Oral Anticoagulation 2012: VTE, Atrial Fibrillation, and Valvular Heart Disease (page 146) Special JACC Session: How to Write and Evaluate Medical Journal Articles (page 148) Maintenance of Certification (MOC) Course and ABIM Simulation Sessions The MOC Course will prepare you with the 2010, 2011, and 2012 update modules, enhance your knowledge base, and get you updated for your ten-year recertification on the ABIM and ABVM exams. You can earn up to 30 credit points from the home study module sessions at the MOC Course and an additional 20 credit points for participating in the Practice Improvement Module (PIM). TCT can offer you up to 50 credit points, half of the 100 credit points needed to sit for the secure recertification examination. Please see pages 120 and 140 for complete listings or visit Hands on Hearts Pavilion Hands on Hearts includes actual pathological specimens demonstrating human heart disease as well as CT-generated casts of human hearts prior to intervention, ventricular septal defects, valvular pathology, cardiomyopathies, and coronary anomalies. Don t miss the scheduled live demonstration vignettes that will be displayed on a large screen in the extended area of Hands on Hearts. Please visit the Hands on Hearts Pavilion in Hall A of Miami Beach Convention Center. Hands on Hearts Pavilion Hours Wednesday and Thursday, October :00 am-5:00 pm Friday, October 26 9:00 am-12:00 pm Hands on Hearts Live Demonstrations Wednesday, October 24 10:00 am-10:30 am - Aortic Valve Disease and Normal Anatomy 3:00 pm-3:30 pm - Mitral Valve Disease and Normal Anatomy Thursday, October 25 10:00 am-10:30 am - Atrial Septal Defects, PFOs, and Atrial Appendage Anatomy 3:00 pm-3:30 pm - Aortic Valve Disease and Normal Anatomy 20

23 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics ABCs of Interventional Cardiology: An Introductory Course This five-hour course (page 50), held Sunday, October 21, the day before the opening of TCT, will provide a primer for physicians, allied health professionals, and others interested in the basics of cardiac anatomy and angiography, cardiovascular pathophysiology, and an introduction to coronary angioplasty/stenting. Special Twilight Sessions For the first time all the Twilight Sessions will be hosted on one evening only: Monday, October 22. Special Twilight Sessions will highlight featured clinical research, presentations on the hottest topics in interventional cardiology, and hosted must-see international sessions in a more casual setting with hors d oeuvres. Please see pages for complete listings or visit Lunchtime Sessions Learn the Technique sessions (pages 127, 148, and 160) will demonstrate step-by-step approaches to advanced interventional techniques, relying heavily on patient cases to showcase tips and tricks to achieve success while avoiding (and, if necessary, managing) complications. Hot Topics (pages 125, 146, and 159) will cover current controversies and other special topics. Spotlight Sessions Spotlight Sessions (pages 123, 130, 142, 151, and 157) offer focused, clinical issuecentered sessions with featured lectures, case presentations, and special summary sessions. TCT: An Integrated Course for Surgeons and Interventionalists The integrated course within TCT Week will be of special interest to cardiac and vascular surgeons and general cardiologists, highlighting advanced techniques and emerging devices specific to cardiovascular surgery as well as emphasizing areas of percutaneous and minimally invasive therapies including transcatheter valve therapies and structural heart and aortic aneurysm repair. Please see page 6 for complete listings or visit 21st Annual Cardiovascular Nurse and Technologist Symposium Join us as we celebrate the 21st anniversary of this symposium. TCT for Nurses and Technologists is the preeminent forum to learn and discuss the latest advances in interventional, pharmacologic, structural heart, and endovascular strategies for the management of the cardiovascular patient. Please see page 6 for listings or visit Networking TCT Global Educational Partnerships TCT Booth 459 Come visit over a dozen international organizations which CRF has collaborated with throughout the year in presenting educational programs outside the United States. You will have the opportunity to network with your colleagues, relax and have a café latte in the morning and smoothies and popcorn in the afternoon. The booth will be equipped with wireless and you can charge your laptop. p-c-i live with TCT November 29-30, 2012 Munich, Germany Innovations in Cardiovascular Interventions (ICI) December 2-4, 2012 Tel Aviv, Israel Taiwan Transcatheter Therapeutics (TTT): Highlights of TCT 2012 January 12-13, 2013 Taipei, Taiwan Joint Interventional Meeting (JIM) 2013 February 14-16, 2013 Rome, Italy China Interventional Therapeutics (CIT) in Partnership with TCT March 20-23, 2013 Beijing, China TCT Mediterranean April 2013 Turkey Angioplasty Summit-TCTAP April 23-26, 2013 Seoul, South Korea TCT Russia June 9-11, 2013 Moscow, Russia GI2 Global Summit on Innovations in Interventions in Partnership with TCT July 24-26, 2013 São Paulo, Brazil Sociedad Latino Americana de Cardiologia Intervencionista (SOLACI) in Partnership with TCT July 24-26, 2013 São Paulo, Brazil Advanced Cardiovascular Solutions (ACVS) in Partnership with TCT August 3-5, 2013 Hyderabad, India Colegio Argentino de Cardioangiólogos Intervencionistas (CACI) October 3-6, 2013 Buenos Aires, Argentina Partnership Pavilion Come visit the CRF Partnership Pavilion booth outside the Main Arena to learn about the services CRF offers and also meet representatives from the American College of Cardiology (ACC) and NewYork-Presbyterian/ Columbia University Medical Center. For more information about each of these organizations, please visit CRF at ACC at NewYork-Presbyterian at and Columbia University Medical Center at Exhibit Hall Opening Please join us at the opening of the Exhibit Hall for lunch at 12:00 pm on Tuesday, October 23. The Exhibit Hall will help you explore and discover the latest developments with industry leaders in interventional cardiology. Exhibit Hall Hours Tuesday, October 23 12:00 pm-5:00 pm Wednesday and Thursday, October :00 am-5:00 pm Art from the Heart Art from the Heart is a sculpture exhibition provided by the international award-winning sculptor Akiva Huber. Please visit Mr. Huber s exhibition during TCT outside the How to Treat Theaters in Hall A. 21

24 special Activities In Memorium Special Memorial to Geoffrey O. Hartzler, MD Please join us in the Main Arena for a memorial to Geoffrey O. Hartzler, MD, including a special video tribute of Dr. Hartzler in his own words. Please see page 116 for the memorial session. Wednesday, October 24 Plenary Session III. A Memorial to Geoffrey O. Hartzler, MD 9:35 am-10:20 am Main Arena (Hall D) Meals at TCT Lunches will be served during Scientific Symposia (Monday, October 22), at the opening of the Exhibit Hall (Tuesday, October 23), and during lunchtime activities (Wednesday through Friday, October 24-26). Concession stands will be available throughout the Exhibit Hall and the Miami Beach Convention Center and will include a kosher stand this year. Technology Smart Tags at TCT With only your mobile device, access detailed information and the slides from the late breaking trial presentations and abstract posters. Smart tags will be located on the signs outside the room where late breaking trials are presented and in the Poster Abstract Sessions. CRF Meetings App for iphone/ipad and Android The CRF Meetings App is made possible through support from Cook Medical Keeping up to date with news and finding the best sessions at TCT has never been easier with our free app. You can get up-to-date information on TCT, search agendas, exhibitors, and faculty, add sessions to your calendar, and view the Virtual TCT stream. You can rate speakers, sessions, and cases with the app and network with faculty and other attendees. The free CRF Meetings App is available for download from itunes and Google Play. TCTMD Premium Enhance the unparalleled educational experience available at TCTMD.com with access to PowerPoint slides, webcasts of TCT presentations, live case videos, and a host of educational content from TCT and other leading meetings in interventional cardiology. New this year, all TCTMD premium content is now available from within the TCTMD mobile app. Visit the TCTMD booth during TCT or to learn more and test drive TCTMD s premium offerings, TCTMD Gold and TCTMD Prime. TCTMD Gold provides unlimited access to more than 10,000 PowerPoint slides and webcast presentations from TCT, TVT, and premier interventional cardiology conferences as well as a library of live case videos from cath labs around the world. TCTMD Gold members have access to all of TCTMD s content, premium and standard. TCTMD Prime offers preparation for the interventional board exam and ongoing interventional education. TCTMD Prime includes PowerPoint slides and webcasts of all presentations from the annual TCT Board Review Course with Self-Assessment and CRF s annual Fellows Courses as well as access to all factoid PowerPoint slides. TCTMD Prime members also receive biweekly e-newsletters with multiple choice questions and answers similar to those on the board exams. TCTMD Mobile App Stay up-to-date with content from TCT by downloading the free TCTMD mobile app for iphone and ipad. The app provides TCTMD subscribers with access to all TCTMD Web site content, including daily news articles, case studies, and TCTMD premium content in a mobile friendly format. TCTMD s professional networking program, TCTMD Connect, is also included and allows subscribers to communicate with colleagues and follow the TCT Blog while on the go. The free TCTMD App is available for download from itunes. Virtual TCT Virtual TCT delivers live and on-demand viewing of the Main Arena during TCT 2012 and for 30 days after the conference. Access to Virtual TCT is provided complimentary to registered TCT Week and TCT in 3 attendees. Wednesday and Thursday, October :00 am-6:00 pm Friday, October 26 8:00 am-3:15 pm Learning Labs Learning Labs are dedicated to creating an intimate educational atmosphere in which physicians and healthcare professionals can interact with a company s clinical specialist to enhance their knowledge and understanding of treatment techniques and devices. Learning Lab Sponsored by Medtronic, Inc. Medtronic ilab At the Medtronic ilab, registrants will experience a range of new manufacturing technologies and therapy innovations currently in development at Medtronic. Medtronic s ilab is conveniently located in the Exhibit Hall with sessions Tuesday through Thursday, October 23-25, during Exhibit Hall hours. Attendees may visit the Medtronic ilab in the Exhibit Hall to register for an appointment. Physician Training Center Be sure to visit the Physician Training Center where you will have the opportunity to view our 3-D movies highlighting aortic valve demonstrations, mitral valve demonstrations, and demonstrations of other anatomies. And in this area you can test your skills and knowledge on a number of simulation applications. 22

25 CardiovasC ular r esearc h Foundation Educational Activities Save the Dates Save the dates for these upcoming meetings sponsored by the Cardiovascular Research Foundation. p-c-i Live with TCT China Interventional Angioplasty Summit-TCTAP Sociedad Latino November 29-30, 2012 Therapeutics (CIT) in April 23-26, 2013 Americana de Cardiologia Munich, Germany Partnership with TCT Seoul, South Korea Intervencionista (SOLACI) Annual Pulse of the City Gala December 14, 2012 March 20-23, 2013 Beijing, China Optimizing PCI Outcomes TCT Mediterranean April 2013 Turkey in Partnership with TCT July 24-26, 2013 São Paulo, Brazil Conference on Cell Therapy for Cardiovascular Disease March 2013 San Francisco, CA ACC.13/i2 Summit with TCT TCT Russia June 9-11, 2013 Moscow, Russia Gi2 with TCT July 24-26, 2013 São Paulo, Brazil January 23-25, 2013 Complex PCI: Left Main and CTO Summit February 21-23, 2013 March 9-11, 2013 San Francisco, CA Interventional Cardiology Fellows Course April 14-17, 2013 Transcatheter Valve Therapies (TVT) 2013 June 12-15, 2013 Vancouver, Canada Transcatheter Cardiovascular Therapeutics (TCT) 2013 Oct 28-Nov 1, 2013 San Francisco, CA San Jose, CA Visit us at the Partnership Pavilion located in Hall D, Level 1.

26 Joint Activities Joint Conflict of Interest (COI) and Relationship with Industry (RWI) Policies of the Cardiovascular Research Foundation (CRF) and the American College of Cardiology Foundation (ACC) CRF/ACC require and collect disclosure of relationships with industry (RWI) from all individuals who are in a position to control or influence educational content. This is done annually in conjunction with all of CRF s meetings and educational offerings for which CME is offered (including TCT, CRF s major annual educational event) and all of ACC s meetings and educational offerings for which CME is offered (including the annual ACC scientific session). All individuals involved in directing, planning, and delivering educational content for CRF and ACC (course directors, planning committee members, faculty, staff, etc) are required to submit RWI disclosures prior to participation; otherwise their participation in the event is precluded. If disclosure of RWI information is not already on file at the inception of a new activity, that information is collected at confirmation of individual participation. This information is also confirmed and updated prior to the development of each CME activity to ensure that the most up-to-date information is collected and available. Likewise, nonphysician staff are required to complete RWI Disclosure Declaration forms. COI (RWI) Declaration The online Required Faculty Disclosure Declaration form requires each individual to identify financial relationships that he or she and/or his or her spouse or partner have had with any organization within the preceding 12 months or that is anticipated in the next 12 months that could be perceived as a relevant conflict of interest. Any individual who does not complete the form is not permitted to participate; this includes course director(s) and planners (who are then excluded from planning the activity) as well as faculty. For a live activity, each faculty is required to check-in upon arrival; and faculty who have not completed their RWI declarations are not allowed to enter the CME activity. For enduring activities, the CME product is not published, either online or in print, until all declarations are completed. COI Resolution Director(s) and planning committee members are required to complete the COI Resolution form prior to content development. In the event that a conflict of interest exists, the activity content is reviewed by course director(s), planning committee members, CME committee members, or designees who do not have conflicts of interest. Speakers, Presenters, Moderators, Panelists, and Live Case Operators who have declared a COI or RWI are required to complete a COI Resolution form online to indicate that they will resolve their conflict(s) by one or more of the following: 1. Confirming that no patient care recommendations will be made to the learners regarding the use of drugs or devices from companies with which they have a financial relationship 2. Confirming that if patient recommendations will be made to the learners regarding the use of drugs or devices from companies with which they have a financial relationship, the conflict will need to be resolved (see next paragraph) 3. Submitting an alternate resolution of the conflict that is then reviewed by the CME Committee, course director(s) and/ or planning committee, and if acceptable, approved 4. Recommending an alternate speaker 5. Agreeing to divest themselves of the financial relationship Upon receipt of the COI Resolution form, the course director(s), planning committee members, or CME committee members or their designees review each COI Resolution form to determine the course of action, if any, necessary to resolve the conflict. Possible conflict resolution mechanisms, based on the educational design of the program, include using a variety of approaches including, but not limited to: 1. Knowledge of speakers (for example, in the past has the individual participated in unbiased presentations, discussions, published literature, etc) 2. Knowledge of content 3. Interview with speakers 4. Slide peer review 5. Abstract peer review 6. Replacing the presenter For TCT and ACC annual scientific sessions where presentations number in the thousands, a committee is formed to review all faculty financial relationships to determine whether slide review is necessary; if so, slides are reviewed prior to presentation and, when necessary, changes are recommended and implemented. In July 2010, in response to an ACCME update, sessions with industry employee speakers are allowed to be certified under the following circumstances: 1. The presentation is about the scientific or discovery process itself 2. The presentation is about products that have not yet entered the clinical arena (including products that are under investigation) 3. Presentation slides are submitted at least 2 weeks before the start of the CME activity, and the presenter agrees in advance to any and all modifications requested by the CME committee 24

27 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics Disclosure to Attendees Standard practices to ensure that faculty financial relationships are disclosed to the learners prior to the activity include: 1. Online disclosures available only at 2. A COI slide prepared by the presenter is inserted at the beginning of the presentation. COI slide templates are ed to all faculty approximately one month prior to the activity. Audiovisual vendors review each presentation to ensure that a COI slide has been inserted, and are instructed not to load or confirm the speaker s presentation without a valid COI slide being present. Additional Policies of the Cardiovascular Research Foundation CRF requires members of the Board of Directors, all employees, and affiliated physicians to disclose on an annual basis any relevant financial interests. The process is managed and the policy is enforced by CRF s Compliance Oversight Review Committee of the Board of Directors and its Compliance Officer. For the TCT scientific sessions, abstracts are peer-reviewed and if accepted are presented at the meeting and published in the Journal of the American College of Cardiology. Approximately 379 physicians grade the abstracts, 82% of whom are TCT Course Directors, Co-directors, or Associate Directors, planning committee members, or faculty, and their Disclosure Declarations are on file. The abstract review process is performed online, is blinded, and requests reviewers to recuse themselves from grading abstracts for which they may have a COI or RWI. Ten reviewers are assigned to grade each abstract, and the high and low scores are discarded. This process was selected to mitigate the effect of any one individual who may have a conflict of interest. Late Breaking Trial review is also performed online similar to the abstract review process. For TCT 2011, 25 physicians graded the Late Breaking Trial submissions with an average of 16 reviewing each study. As part of the selection process, outlier as well as mean scores are reviewed to confirm that grading is fair. For all live activities except TCT, CRF has mandatory slide review for all individuals, even individuals who attest that (1) recommendations will be based on data and findings from peer-reviewed sources or, in the absence of adequate peerreviewed material, will rely on the best available evidence based medicine, and (2) content will be fair and balanced, and if any product specific drugs or devices are discussed, alternative drugs or devices will be discussed. Slides are reviewed prior to presentation, and when necessary, changes are recommended and implemented. Faculty members at all CRF educational events are instructed to communicate verbally to the audience the RWIs displayed on the COI slide. CRF s audiovisual vendor has developed a system that requires that the COI slide cannot be advanced until a sufficient time has elapsed to allow it to be read by the audience. 25

28 CME/CNE Information Overview Transcatheter Cardiovascular Therapeutics (TCT) is the world s largest and most important educational meeting specializing in interventional cardiovascular medicine. For more than 20 years, TCT has been the center of the latest advances in current therapies and clinical research. CME Accreditation and Designation The Cardiovascular Research Foundation is accredited by the Accreditation Council for Continuing Medical Education to provide continuing medical education for physicians. The Cardiovascular Research Foundation designates this live activity for a maximum of AMA PRA Category 1 Credits. Physicians should claim only the credit commensurate with the extent of their participation in the activity. One contact hour equals 60 minutes of learning time. This does not include Breakfast Meetings, Evening Symposia, or other specialty programs such as Hands on Hearts. Documentation of awarded credit is provided for registered attendees in exchange for completed online activity evaluations. Certificates of attendance are provided to all registered attendees in their meeting bags. CNE Accreditation and Designation The American College of Cardiology Foundation (ACCF) is accredited as a provider of continuing nursing education by the American Nurses Credentialing Center s Commission on Accreditation. The ACCF designates TCT 2012 educational activity for a maximum of 43.5 contact hours. Requirements for successful completion are attendance at TCT 2012 sessions offering continuous nursing education in their entirety and completing the evaluation tool. Each nurse/ nurse practitioner attendee may only claim the contact hours commensurate with the extent of their separate or combined successful completion in the activities. Target Audience This symposium is designed for interventional cardiologists, radiologists, clinical cardiologists, basic scientists, vascular medicine specialists, cardiac and vascular surgeons, nurse practitioners, nurses, cath lab technicians, and other health care professionals with a special interest in the field of interventional and vascular medicine. Needs Statement TCT provides the latest evidence-based data presented by leading physicians, nurses, and scientists that will affect the practice of interventional cardiology and endovascular medicine, current and emerging techniques and technologies with practical applications, and unparalleled diversity of live-case presentations from universities and medical centers around the world. In the field of interventional cardiology, only TCT combines late breaking science and practical learning that physicians need to improve patient outcomes. Activity Goals The overall goal of this activity is to improve competence and performance of our target audience by delivering new cutting-edge educational content that showcases the latest advances in current therapies and clinical research. We hope that our long-standing commitment to life-saving innovation will translate into improved patient care. Learning Objectives By the end of the symposium, participants should be able to: Apply the results from important clinical trials and evidence-based medicine to guide management of patients with atherosclerosis and structural heart disease Incorporate new interventional technologies and procedures into the care of patients with complex coronary and endovascular disease Integrate advances in diagnostic evaluation and therapeutics to patients with carotid and peripheral arterial disease Implement appropriate pharmacologic management in the care of patients undergoing diagnostic arteriography and interventional therapies before, during, and after catheterization Identify new interventional technologies and propose appropriate applications for patients with cardiovascular disease Disclosure Statement It is the policy of the Cardiovascular Research Foundation and the American College of Cardiology Foundation to ensure balance, independence, objectivity, and scientific rigor in all of its sponsored educational activities. Commercial support from industry does not influence educational content, faculty selection, and/or faculty presentations, and, therefore, does not compromise the scientific integrity of the educational activity. Discussion of off-label product usage and/or off-label product use during live cases is made at the sole discretion of the faculty. Off-label product discussion and usage are not endorsed by the Cardiovascular Research Foundation, the American College of Cardiology Foundation or the conference directors of this activity. Faculty participating in continuing medical education activities sponsored by the Cardiovascular Research Foundation and the American College of Cardiology Foundation are required to disclose to the activity audience any real or apparent conflicts of interest related to the content of their presentations. Faculty not complying with this policy are not permitted to participate in this activity. CME and CNE Credit Claim To claim your CME or CNE credits, please visit Successful completion requires a brief evaluation for each of the sessions attended as well as an evaluation for the TCT conference as a whole. Evaluations will address content, presentation, possible bias, and future educational needs. For any CME or CNE related inquiry, please contact [email protected]. Program Sponsorship This symposium is sponsored by the Cardiovascular Research Foundation. This symposium is co-provided by the American College of Cardiology Foundation. Program Support This symposium is partially funded through educational grants from commercial supporters. The Cardiovascular Research Foundation and the American College of Cardiology Foundation ensure that these programs are educational and meet the needs of the target audience. To support this endeavor, the directors and co-directors of TCT create organizational and scientific committees to assist in educational content development and content oversight for live cases, concurrent sessions, case reviews, abstract sessions, practical workshops, and scientific symposia. These sessions are developed without influence from commercial supporters. Disclaimer Nonendorsement of Products Accredited status does not imply endorsement by the ANCC of any commercial products displayed in conjunction with this activity. 26

29 The World s Premier Interventional Experience TCT2012 Special Tribute to Geoffrey O. Hartzler, MD The Original Master Operator Transcatheter Cardiovascular Therapeutics Wednesday, October 24 Main Arena Plenary Session III. A Memorial to Geoffrey O. Hartzler, MD 9:35 am-10:20 am With the passing this March of Geoffrey O. Hartzler, MD, who performed the first coronary angioplasty to treat acute myocardial infarction (MI) in 1979 at the Mayo Clinic, the world lost a true medical pioneer. Dr. Hartzler earned his MD from Indiana University, Bloomington, in 1972 and started the angioplasty program at the Saint Luke s Mid America Heart Institute (Kansas City, MO) in He broadened the reach of angioplasty from simple discrete lesions to complex lesions and patients including multivessel disease, chronic total occlusions, and acute MI. Dr. Hartzler and his colleagues trained a generation of cardiologists around the world in PCI, through the use of live and taped cased at the biannual Hartzler courses in Kansas City and Hawaii. His creation of the first comprehensive computerized database in interventional cardiology set the standard for critical outcomes analysis for the subspecialty and served as the spark for today s emphasis on evidence-based medicine to guide patient clinical decision-making. Dr. Hartzler founded the first Advanced Angioplasty Fellowship, which has been the template for programs around the world. His trainees include TCT Course Director Gregg W. Stone, MD, of Columbia University Medical Center, New York, among many other well-known names. In 2009, the Master Clinical Operator Award given annually at TCT to recognize an interventional operator who has distinguished himself or herself as an innovator in the field was named for Dr. Hartzler. Please see page 116 for the memorial session. 27

30 TCT 2012 Awards Please join us in the Main Arena for the presentation of the following awards: Geoffrey O. Hartzler Master Clinical Operator Award Wednesday, Ocotber 24, at 10:20 am 2009 Eberhard Grube, MD 2010 Osamu Katoh, MD Takahiko Suzuki, MD Hideo Tamai, MD 2011 Horst Sievert, MD 2012 Barry D. Rutherford, MD TCT Career Achievement Award Thursday, Ocotber 25, at 11:00 am 1994 Geoffrey O. Hartzler, MD 1995 David R. Holmes, MD 1996 Patrick W. Serruys, MD, PhD 1997 John B. Simpson, MD 1998 Antonio Colombo, MD 1999 Julio C. Palmaz, MD 2000 Donald S. Baim, MD 2002 William W. O Neill, MD 2003 J. Eduardo M.R. Sousa, MD, PhD 2004 Eugene Braunwald, MD 2005 James T. Willerson, MD 2006 Paul Yock, MD 2007 Barry T. Katzen, MD 2008 Seung-Jung Park, MD 2009 Spencer B. King III, MD 2010 Alain G. Cribier, MD 2011 Eric J. Topol, MD 2012 Renu Virmani, MD Thomas J. Linnemeier Spirit of Interventional Cardiology Young Investigator Award Friday, October 26, at 11:00 am 2003 David E. Kandzari, MD 2004 Farouc Jaffer, MD, PhD 2005 Giuseppe De Luca, MD 2006 Alaide Chieffo, MD 2007 Wojciech Wojakowski, MD, PhD 2008 Mehdi H. Shishehbor, DO, MPH 2009 Robert A. Byrne, MD 2010 Colin M. Barker, MD 2011 Davide Capodanno, MD Robert W. Yeh, MD 2012 Finalists Ehrin J. Armstrong, MD, MSc Philippe Généreux, MD Giulio G. Stefanini, MD 28

31 October 22-26, 2012 MIAMI BEACH CONVENTION CENTER MIAMI, FL Week at a Glance TCT2012 9:30 pm 9:00 pm 8:30 pm 8:00 pm 7:30 pm 7:00 pm 6:30 pm 6:00 pm 5:30 pm 5:00 pm 4:30 pm 4:00 pm 3:30 pm 3:00 pm 2:30 pm 2:00 pm 1:30 pm 1:00 pm 12:30 pm 12:00 pm 11:30 am 11:00 am 10:30 am 10:00 am 9:30 am 9:00 am 8:30 am 8:00 am 7:30 am 7:00 am Registration: All Attendees and Exhibitors SUNDAY, 10/21 ABCs of Interventional Cardiology Registration: All Attendees and Exhibitors TCT for Surgeons Scientific Symposia MONDAY, 10/22 Board Review Course with Self-Assessment for Interventional Cardiology (Part 1) 21st Annual Nurse and Technologist Symposium Registered Cardiovascular Invasive Specialists (RCIS) Review Course Special Twilight Sessions Breakfast Meetings Poster Abstracts Oral Abstracts Scientific Symposia Board Review Course with Self-Assessment for Interventional Cardiology (Part 2) TCT for Surgeons Lunch in Exhibit Hall TCT for Surgeons TUESDAY, 10/23 Presentation Theater 21st Annual Nurse and Technologist Symposium Exhibit Hall Evening Programs Breakfast Meetings Maintenance of Certification (MOC) Session The World s Premier Interventional Experience Main Arena How to Treat Theater: Coronary Artery Disease How to Treat Theater: Structural Heart Disease How to Treat Theater: Endovascular Disease Learn the Technique Lunchtime Sessions Spotlight Sessions Spotlight Sessions WEDNESDAY, 10/24 Hot Topic Lunchtime Sessions International Multiplex Theater International Multiplex Theater TCT2012 TCT for Surgeons TCT for Surgeons Presentation Theater Exhibit Hall Evening Programs Breakfast Meetings Maintenance of Certification (MOC) Session Main Arena How to Treat Theater: Coronary Artery Disease How to Treat Theater: Endovascular Disease How to Treat Theater: Structural Heart Disease Learn the Technique Lunchtime Sessions Spotlight Sessions Spotlight Sessions Transcatheter Cardiovascular Therapeutics THURSDAY, 10/25 Hot Topic Lunchtime Sessions International Multiplex Theater International Multiplex Theater TCT for Surgeons FDA Town Hall Meeting 29 Presentation Theater Exhibit Hall Evening Programs Breakfast Meetings Main Arena How to Treat Theater: Coronary Artery Disease FRIDAY, 10/26 Learn the Technique Lunchtime Sessions Spotlight Sessions Sunday - october 21, 2012 Hot Topic Lunchtime Sessions

32 CARDIOVASCULAR RESEARCH FOUNDATION Center for Education For more information, contact: Johnnie White, CMP Executive Director, Meetings and Educational Services Tel: Josh D. Hartman Director, Educational Services and Strategic Relations Managing Editor, TCTMD Tel: Looking for someone to execute a flawless meeting, symposia, conference, or educational program on your behalf? You found us. STRATEGIC PLANNING MEETING LOGISTICS PROGRAM DEVELOPMENT FACULTY MANAGEMENT POST-MEETING RECONCILIATION MARKETING AND BRANDING GRAPHIC DESIGN WEB SITE DEVELOPMENT VIDEO AND INTERACTIVE MEDIA E-LEARNING CRF is certified to accredit programs for continuing medical education (CME). Visit us at the Partnership Pavilion located in Hall D, Level 1. CARDIOVASCULAR RESEARCH FOUNDATION a passion for innovation

33 transcatheter cardiovascular therapeutics twenty-fifth AnniversAry Save the date Oct 28-NOv 1, 2013 SaN FraNciScO the MOScONe center

34

35 International Faculty Alexandre Abizaid, MD, PhD Instituto Dante Pazzanese de Cardiologia São Paulo, Brazil Andrea Abizaid, MD, PhD Instituto Dante Pazzanese de Cardiologia São Paulo, Brazil Sergey A. Abugov, ScD BV Petrovsky Russian Centre of Science of Surgery Moscow, Russia Madhavpeddi Sai Aditya, MD Nizam s Institute of Medical Sciences Hyderabad, India Tom Adriaenssens, MD University Hospitals Leuven Leuven, Belgium Taehoon Ahn, MD, PhD Gachon University Gil Medical Center Incheon, South Korea Yasushi Asakura, MD Toyohashi Heart Center Toyohashi, Japan Abid R. Assali, MD Rabin Medical Center Petah Tikra, Israel Ihab Attia, MD Ain Shams University Giza, Egypt Panayiotis Avraamides, MBBS Limassol General Hospital Nicosia, Cyprus Zdravko Babic, MD, PhD University Hospital Sestre Milosrdnice Zagreb, Croatia Jorge A. Baccaro, MD Instituto de CardiologÌa de Corrientes Juana F. Cabral Corrientes, Argentina Edouard R. Benit, MD Jessa Ziekenhuis Hasselt, Belgium Lee N. Benson, MD The Hospital for Sick Children Toronto, Canada Ivo Bernat, MD, PhD University Hospital Pilsen Pilsen, Czech Republic Robert Bernat, MD, PhD Magdalena Clinic for Cardiovascular Diseases Krapinske Toplice, Croatia Chiara Bernelli, MD San Raffaele Hospital, Milan Milan, Italy Sergio Berti, MD CNR-Institute of Clinical Physiology Massa, Italy Alessandro S. Bortone, MD, PhD Interventional Lab Cardiac Surgery University of Bari Bari, Italy Roberto Botelho, MD, PhD Triangulo Heart Institute Uberlandia, Brazil Marian Branny, MD Hospital Podlesi Trinec, Czech Republic Stephen J.D. Brecker, MD St. George s Hospital London, United Kingdom Carlo Briguori, MD, PhD Clinica Mediterranea Naples, Italy Elchanan Bruckheimer, MBBS Schneider Children s Medical Center Petach Tikva, Israel Takashi Akasaka, MD, PhD Wakayama Medical University Wakayama, Japan Marco Alcantara, MD Instituto Nacional de Cardiologia Mexico City, Mexico Bagrat Alekyan, MD, PhD Bakoulev Center for Cardiovascular Surgery RAMS Moscow, Russia Dimitrios Alexopoulos, MD Patras University Hospital Patras, Greece Fernando Alfonso, MD, PhD Hospital Universitario San Carlos Madrid, Spain Yaron Almagor, MD Shaare Zedek Medical Center Jerusalem, Israel Jose A. Alvarez, MD Universidad del Salvador Buenos Aires, Argentina Max Amor, MD Clinique Louis Pasteur Essey-les-Nancy, France Robert Amyot, MD CAE Healthcare Montreal, Canada Henning Rud Andersen, MD University of Aarhus Aarhus, Denmark Teeranan Angkananard, MD Vajira Hospital Bangkok, Thailand Stefan Anker, MD, PhD Charité, Campus Virchow-Klinikum Berlin, Germany David Antoniucci, MD Careggi Hospital Florence, Italy Priyadarshini Arambam, MD Institute and Fortis Vasant Kunj New Delhi, India Akaki Archvadze, MD N. Kipeshidze Central University Hospital Tbilisi, Georgia Vinay K. Bahl, MD, DM All India Institute of Medical Sciences New Delhi, India Stephan Baldus, MD University Hospital of Hamburg-Eppendorf Hamburg, Germany Shmuel Banai, MD Tel Aviv Medical Center Tel Aviv, Israel Amal Kumar Banerjee, MD, DM Advanced Medical Research Institute Kolkata, India Adrian P. Banning, MD John Radcliffe Hospital Oxford, United Kingdom Vinayak Bapat, FRCS, CTh Guy s and St. Thomas London, United Kingdom Thomas Bartel, MD Medical University Innsbruck Innsbruck, Austria Antonio L. Bartorelli, MD University of Milan Milan, Italy Jozef Bartunek, MD, PhD Cardiovascular Center, OLV Hospital Aalst, Belgium Stanislaw Bartus, MD Jagiellonian University Medical College Iwanowice, Poland Andreas Baumbach, MD Bristol Heart Institute Bristol, United Kingdom Jeroen J. Bax, MD Leiden University Medical Center Leiden, The Netherlands Kevin J. Beatt, MBBS, PhD Croydon University Hospital London, United Kingdom Francesco Bedogni, MD Istituto Clinico S. Ambrogio Milano, Italy Jorge A. Belardi, MD Instituto Cardiovascular de Buenos Aires Buenos Aires, Argentina Olivier F. Bertrand, MD, PhD Institut Universitaire de Cardiologie et de Pneumologie de Québec Quebec City, Canada Rafael Beyar, MD, DSc Rambam Medical Center Haifa, Israel Silvio Bezerra, MD Universidade Federal de Rio Grande do Norte Natal, Brazil Balram Bhargava, MD, DM All India Institute of Medical Science New Delhi, India Sanjeev Bhatt, MD Meril Life Sciences Pvt. Ltd. Vapi, India Giancarlo Biamino, MD, PhD Clinica Montevergine Mercogliano, Italy Giuseppe Biondi Zoccai, MD Sapienza University of Rome Latina, Italy Daniel J. Blackman, MD Leeds General Infirmary Leeds, United Kingdom Erwin Blessing, MD University of Heidelberg Heidelberg, Germany Jorge Bluguermann, MD Policlinica Bancaria Buenos Aires, Argentina Wolfgang Bocksch, MD, PhD Tubingen University Hospital Tubingen, Germany Peter Boekstegers, MD, PhD Heart Center Siegburg Siegburg, Germany Michael Böhm, MD University Hospital of Saarland Homburg/Saar, Germany Raoul Bonan, MD Montreal Heart Institute Montreal, Canada Laurent Bonello, MD Hôpital Universitaire Nord Marseille, France Lutz Buellesfeld, MD Bern University Hospital Bern, Switzerland Siro Buendia, MD Son Espases Palma de Mallorca Palma de Mallorca, Spain Francesco Burzotta, MD, PhD Institute of Cardiology, Catholic University of the Sacred Heart Rome, Italy Jacques Busquet, MD Clinique Chirurgicale Val d Or Paris-Saint Cloud, France Pawel E. Buszman, MD, PhD American Heart of Poland Katowice, Poland Robert A. Byrne, MB, BCh, PhD Deutsches Herzzentrum Munich, Germany Adriano Caixeta, MD, PhD Hospital Israelita Albert Einstein São Paulo, Brazil Patrick A. Calvert, MD, PhD Papworth Hospital NHS Foundation Trust Cambridge, United Kingdom Edoardo Camenzind, MD University Hospital of Geneva Geneva, Switzerland Felipe De Jesus Gonzalez Camid, MD Hospital San Jose Tec de Monterrey San Pedro Garza García, Mexico Davide Capodanno, MD, PhD Ferrarotto Hospital Catania, Italy Mauro Carlino, MD San Raffaele Hospital Milan, Italy Mario Carminati, MD Istituto Policlinico San Donato Milan, Italy Didier Carrié, MD, PhD Hôpital Rangueil Toulouse, France Graham A. Cassel, MD Milpark Hospital Johannesburg, South Africa 33

36 International Faculty Salvatore Cassese, MD Deutsches Herzzentrum München, Germany Alp Burak Catakoglu, MD Florence Nightingale Hospitals Istanbul, Turkey Murat Cayli, MD Adana Numune Education and Research Hospital Adana, Turkey Pavel Cervinka, MD, PhD Masaryk Hospital ÚstÌ nad Labem, Czech Republic Inho Chae, MD, PhD Seoul National University Bundang Hospital Seongnam, South Korea Charles Chan, MD Gleneagles Medical Centre Singapore Praveen Chandra, MD Medanta Medicity Hospital Guragon, India Virendrasinh C. Chauhan, MD Bhailal Amin Hospital Vadodara, India Kamaldeep Chawla, MD Sterling Hospital Gujarat, India Jiyan Chen, MD Guangdong Provincial People s Hospital Guangzhou, China Shao Liang Chen, MD Nanjing First Hospital of Nanjing Medical Center Jiangsu, China YunDai Chen, PhD Chinese PLA General Hospital Beijing, China Jun-Jack Cheng, PhD Shin Kong Hospital Taipei City, Taiwan Anson Cheung, MD St. Paul s Hospital Vancouver, Canada Bernard R. Chevalier, MD Institut Cardiovasculaire Paris Sud Massy, France Paul T.L. Chiam, MD National Heart Center Singapore Singapore Alaide Chieffo, MD San Raffaele Scientific Institute Milan, Italy Kenneth Chin, MBBS Pantai Hospital Kuala Lumpur, Malaysia Yoon Sin Chong, MD Serdang Hospital Kajang, Malaysia G.H. Choo, MD Sime Darby Medical Centre Subang Jaya, Malaysia Evald H. Christiansen, PhD Aarhus University Hospital Aarhus, Denmark Christos Christou, MD American Heart Institute Nicosia, Cyprus Kook-Jin Chun, MD Pusan National University Yangsan Hospital Yangsan, South Korea Wook Sung Chung, MD, PhD Catholic University of Korea Seoul, South Korea Eric A. Cohen, MD Sunnybrook Health Sciences Centre Toronto, Canada Antonio Colombo, MD Columbus Hospital/San Raffaele Hospital Milan, Italy Jose A. Condado, MD Centro Medico de Caracas Caracas, Venezuela Stéphane Cook, MD Swiss Cardiovascular Center Fribourg, Switzerland Thierry Corcos, MD American Hospital of Paris Neuilly-sur-Seine, France Kristoff Cornelis, MD AZ Maria Middelares Ghent, Belgium Roberto Corti, MD University Hospital Zurich Zurich, Switzerland Ricardo A. Costa, MD Instituto Dante Pazzanese de Cardiologia São Paulo, Brazil Jose de Ribamar Costa Jr, MD Instituto Dante Pazzanese de Cardiologia São Paulo, Brazil Alberto Cremonesi, MD Maria Cecilia Hospital Cotignola, Italy Alain G. Cribier, MD Hôpital Charles Nicolle Rouen, France Alberto J. Crottogini, MD, PhD Favaloro University Hospital Buenos Aires, Argentina Fernando Cura, MD, PhD Instituto Cardiovascular de Buenos Aires Buenos Aires, Argentina Nick Curzen, BM, PhD Southampton University Hospitals Southampton, United Kingdom Joost Daemen, MD, PhD Erasmus Medical Center Rotterdam, The Netherlands Miles C. Dalby, MD Harefield University Hospitals Harefield, United Kingdom Felix Damas de los Santos, MD Instituto Nacional de Cardiologia Mexico City, Mexico Anibal A. Damonte, MD Instituto Cardiovascular de Rosario Rosario, Argentina Benoit Daneault, MD Centre Hospitalier Universitaire de Sherbrooke Sherbrooke, Canada Haim Danenberg, MD Hadassah Medical Center Jerusalem, Israel Sameer I. Dani, MD Apollo Hospital International Ltd. Ahmedabad, India Debabrata Dash, MD, DM S.L. Raheja Hospital Mumbai, India Justin E. Davies, MBBS, MRCP, PhD Imperial College London NHS Trust London, United Kingdom Adrian Davila Bortoni, MD Centro Medico Ingles Monterrey, Mexico Khairy Abdel Dayem, PhD, MD Ain Shams University Cairo, Egypt Adam J. de Belder, MD Brighton and Sussex University Hospitals Brighton, United Kingdom Mark A. de Belder, MD, MA The James Cook University Hospital Middlesbrough, United Kingdom Bernard De Bruyne, MD, PhD Cardiovascular Center Aalst Aalst, Belgium Jose M. de la Torre Hernandez, MD, PhD Hospital Universitario Marques de Valdecilla Santander, Spain Giuseppe De Luca, MD Eastern Piedmont University Novara, Italy Peter Den Heijer, MD, PhD Amphia Hospital Breda Breda, The Netherlands Marjo de Ronde, RN Erasmus Medical Center Rotterdam, The Netherlands Robbert J. de Winter, MD, PhD Academisch Medisch Centrum Amsterdam, The Netherlands Devang Desai, MD Shree B.D. Mehta Mahavir Heart Institute Gujarat, India Walter Desmet, MD, PhD Katholieke Universiteit Leuven, Belgium Carlo Di Mario, MD Royal Brompton Hospital London, United Kingdom Germano Di Sciascio, MD Campus Bio-Medico University Rome, Italy Stefanie Dimmeler, PhD University of Frankfurt Frankfurt, Germany Henricus J. Duckers, MD, PhD Erasmus Medical Center Rotterdam, The Netherlands Dariusz Dudek, MD, PhD Jagiellonian University Krakow, Poland Ariel Duran, MD University School of Medicine Montevideo, Uruguay VladimÌr DžavÌk, MD Peter Munk Cardiac Centre, University Health Network Toronto, Canada Adrian Ebner, MD Italian Hospital Asuncion, Paraguay Mohammed El Deeb, MD Royal Hospital Muscat, Oman Adel El Etriby, MD Ain Shams University Alexandria, Egypt Helene Eltchaninoff, MD Hôpital Charles Nicolle Rouen, France Stephan M. Ensminger, MD, DPhil Heart and Diabetes Center NRW Bad Oeynhausen, Germany Raimund A. Erbel, MD University Duisburg-Essen Essen, Germany Andrejs Erglis, MD, PhD P. Stradins Clinical University Hospital Riga, Latvia David Erlinge, MD Lund University Hospital Lund, Sweden Aleksander Ernst, MD, PhD Clinical Hospital Center Zagreb Zagreb, Croatia Javier Escaned, MD, PhD Hospital ClÌnico San Carlos Madrid, Spain Jacques R. Essinger, MD Symetis SA Ecublens, Switzerland Joel Estrada Gallegos, MD Hospital de Cardiologia del Centro Medico Nacional Mexico City, Mexico Ali Faizal, MD, DM Malabar Institute of Medical Science Calicut, India Jean Fajadet, MD Clinique Pasteur Toulouse, France El Sayed Farag, MD Zagazig University El-Zakazik, Egypt Vasim Farooq, MD Thoraxcenter Rotterdam, The Netherlands Fausto Feres, MD Instituto Dante Pazzanese de Cardiologia São Paulo, Brazil Francisco Fernandez-Aviles, MD, PhD Hospital General Universitario Gregorio Marañon Madrid, Spain 34

37 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics Gudrun Feuchtner, MD Innsbruck Medical University Innsbruck, Austria Lei Ge, MD Shanghai Zhongshan Hospital Shanghai, China Victor Guetta, MD Heart Institute Chaim Medical Center Tel-Hashomer, Israel Jonathan M. Hill, MD, MRCP King s College Hospital London, United Kingdom Hans R. Figulla, MD Friedrich-Schiller Universitat Jena, Germany Guido Gelpi, MD University of Milan Milan, Italy Wenyi Guo, MD Xijing Hospital Xi?an, China Lynne Hinterbuchner, RN, DGKS Salzburg University Hospital Salzburg, Austria Ariel Finkelstein, MD Tel Aviv Medical Center Tel Aviv, Israel Georgios Georgiou, MD Nicosia General Hospital Nicosia, Cyprus Vivek Gupta, MD, DM Indraprastha Apollo Hospitals New Delhi, India Rainer Hoffmann, MD University Hospital Aachen Aachen, Germany Iraj Firouzy, MD Shahid Rajaei Heart Center Tehran, Iran Ulrich J. Gerckens, MD Hospitial St. Petrus Bonn, Germany Hyeon-Cheol Gwon, MD, PhD Samsung Medical Center Seoul, South Korea Ilona Hofmann, MD Göethe University Frankfurt Frankfurt, Germany Nicolas Foin, MSc, PhD International Centre for Circulatory Health London, United Kingdom Anthony H. Gershlick, MD University of Leicester Leicester, United Kingdom Alison Halliday, MS, FRCS Oxford University Hospitals NHS Trust Oxford, United Kingdom Myeong-Ki Hong, MD, PhD Yonsei University College of Medicine Seoul, South Korea Darrel P. Francis, MD St Mary s and Hammersmith Hospital London, United Kingdom Michal Geva Triventures Herzilya, Israel Michalis Hamilos, MD University Hospital of Heraklion Crete, Greece David Horak, MD District Hospital Liberec Liberec, Czech Republic Douglas G. Fraser, MD Manchester Heart Centre Manchester, United Kingdom Ole Frobert, MD, PhD Orebro University Hospital Orebro, Sweden Xianghua Fu, MD, PhD The Second Hospital of Hebei Medical University Shijiazhuang City, China Alfredo R. Galassi, MD Cannizzaro Hospital Catania, Italy Edvard Galic, MD, PhD Clinical Hospital Sveti Duh Zagreb, Croatia Daljeet S. Gambhir, MD, DM Kailash Hospital and Heart Institute New Delhi, India Habib Gamra, MD University of Monastir Monastir, Tunisia Vladimir Ganyukov, MD Scientific Research Institute for Cardiovascular Diseases Kemerovo, Russia Run-Lin Gao, MD Fu Wai Hospital Beijing, China Eulogio J. Garcia, MD Hospital Clinico San Carlos Madrid, Spain Miguel A. Garcia-Fernandez, MD, PhD Hospital Clinico Universitario San Carlos Madrid Madrid, Spain Hector M. Garcia-Garcia, MD, PhD Thoraxcenter, Erasmus Medical Center Rotterdam, The Netherlands Philippe Garot, MD Institut Cardiovasculaire Paris Sud Quincy-sous-Senart, France Jorge Gaspar, MD National Institute of Cardiology Mexico City, Mexico Efrain Gaxiola, MD Jardines Hospital de Especialidades Jalisco, Mexico Georges Ghanem, MD University Medical Center-Rizk Hospital Beirut, Lebanon Niccoli Giampaolo, MD, PhD Catholic University of the Sacred Heart Rome, Italy Robert J. Gil, PhD Central Clinic Hospital Warsaw, Poland Martine Gilard, MD, PhD Brest University Brest, France Arturo Giordano, MD Pineta Grande Hospital Castelvolturno, Italy Dietmar H. Glogar, MD University of Vienna Vienna, Austria Alejandro Goldsmit, MD CACI SOLACI Buenos Aires, Argentina B.K. Goyal, MD, FRCP Bombay Hospital and Medical Research Centre Mumbai, India Carmelo Grasso, MD Ferrarotto Hospital Cardiology Division Catania, Italy Roger M. Greenhalgh, MD Charing Cross Hospital London, United Kingdom Liliana R. Grinfeld, MD, PhD CENPEC Buenos Aires, Argentina Ladislav Groch, MD University Hospital St. Anna Brno, Czech Republic Eberhard Grube, MD University Hospital Bonn Bonn, Germany Giulio Guagliumi, MD Ospedali Riuniti Di Bergamo Bergamo, Italy Antoine Guédès, MD CHU Mont Godinne-UCL Yvoir, Belgium Christian W. Hamm, MD Kerckhoff Clinic Bad Nauheim, Germany Martial Hamon, MD University Hospital of Caen Caen, France Kyoo-Rok Han, MD, PhD Kangdong Sacred Heart Hospital Seoul, South Korea Yaling Han, MD Shenyang Northern Hospital Shenyang, China Claude Hanet, MD, PhD University of Louvain Medical School Yvoir, Belgium Jan Harnek, MD Skane University Hospital Lund, Sweden Mahmoud Hashemian, MD, FACC Day Hospital, Tehran Tehran, Iran Michael Haude, MD Lukaskrankenhaus Neuss Neuss, Germany Stuart J. Head, MSc Erasmus University Medical Center Rotterdam, The Netherlands Robert A. Henderson, DM Nottingham University Hospitals Nottingham, United Kingdom Christian Hengstenberg, MD Leitender Oberarzt Kardiologie Regensburg, Germany Jose P.S. Henriques, MD, PhD, MBA Academic Medical Center Amsterdam, The Netherlands Michel Camille Henry, MD Cabinet de Cardiologie Nancy, France Yutaka Hikichi, MD Saga University School of Medicine Saga, Japan David J. Hildick-Smith, MD Sussex Cardiac Centre, Brighton and Sussex University Hospitals Brighton, United Kingdom Eric Horlick, MD, CM University Health Network Toronto General Hospital Toronto, Canada Jingbo Hou, MD Harbin Medical University Harbin, China Patrick Houthuizen, MD Catharina Hospital Eindhoven, The Netherlands Angela Hoye, MD, PhD Castle Hill Hospital Kingston-upon-Hull, United Kingdom Hsuan-Li Huang, MD Buddhist Tzu Chi General Hospital Taipei City, Taiwan Kurt Huber, MD Wilhelminen Hospital Vienna, Austria Fernando Huerta Liceaga, MD National Institute of Cardiology Mexico City, Mexico Ioannis Iakovou, MD, PhD Onassis Cardiac Surgery Center Athens, Greece Keiichi Igarashi, MD, PhD Hokkaido Social Insurance Hospital Sapporo, Japan Yuji Ikari, MD, PhD Tokai University School of Medicine Kanagawa, Japan Huseyin Ince, MD, PhD University Hospital Rostock Rostock, Germany Naoto Inoue, MD Sendai Kousei Hospital Sendai, Japan Thomas A. Ischinger, MD, PhD Kardiologie im Zentrum Munich, Germany Louis B. Jacques, MD US Food and Drug Administration Baltimore, MD Ronen Jaffe, MD Carmel Medical Center Haifa, Israel 35

38 International Faculty Stefan K. James, MD Uppsala Clinical Research Center Uppsala, Sweden Osamu Katoh, MD Kusatsu Heart Center Toyohashi, Japan Takashi Kubo, MD, PhD Wakayama Medical University Wakayama, Japan Suhas S. Lele, MD Indian Heart Association Vadodara, India Yang-Soo Jang, PhD Yonsei University Health System Seoul, South Korea Upendra Kaul, MD Fortis Escorts Hospital New Delhi, India Karl-Heinz Kuck, MD Asklepios Hospital St. Georg Hamburg, Germany Pedro A. Lemos, MD, PhD University of São Paulo Medical School São Paulo, Brazil 36 Jens R. Jensen, MD, PhD Sundsvalls Sjukhus Sundsvall, Sweden Lisette Okkels Jensen, MD, DMSci, PhD Odense University Hospital Odense, Denmark Ulf Jens Jensen, MD Department of Cardiology Stockholm, Sweden Gillian A. Jessurun, MD, PhD, MBA Scheper Ziekenhuis Emmen Emmen, The Netherlands Sanjit S. Jolly, MD McMaster University Hamilton, Canada Michael Joner, MD Deutsches Herzzentrum München Munich, Germany Anders Jonsson, MD Sodersjukhuset Stockholm, Sweden Risto Jussila, MD Södersjukhuset Stockholm, Sweden Kazushige Kadota, MD Kurashiki Central Hospital Kurashiki, Japan Christoph A. Kaiser, MD University Hospital Basel Basel, Switzerland Olli A. Kajander, MD Tampere University Hospital, Heart-Center Tampere, Finland Petr Kala, MD, PhD University Hospital and Medical Faculty Masaryk University Brno, Czech Republic Anne K. Kaltoft, MD, PhD Aarhus University Hospital, Skejby Aarhus, Denmark Ioannis (John) Kanakakis, MD, PhD Alexandra University Hospital Athens, Greece Soo-Jin Kang, MD Asan Medical Center Seoul, South Korea Paul Hsien-Li Kao, MD National Taiwan University Hospital Taipai, Taiwan A. Pieter Kappetein, MD, PhD Thoraxcenter Rotterdam, The Netherlands Pasi Karjalainen, MD, PhD Satakunta Central Hospital Pori, Finland Seyed Ebrahim Kassaian, MD Tehran Heart Center Tehran, Iran Adnan Kastrati, MD Deutsches Herzzentrum und Medizinische Klinik der Technischen Universitat Munchen Munich, Germany Zaza Kavteladze, MD The Centre of Endosurgery and Lithotripsy Moscow, Russia Masayuki Kawahara, MD Pharmaceuticals and Medical Devices Agency Tokyo, Japan Elvin Kedhi, MD Maasstad Ziekenhuis Rotterdam, The Netherlands Henning Kelbaek, MD Rigshospitalet Copenhagen, Denmark Alexander N. Kharlamov, MD Ural Institute of Cardiology Yekaterinburg, Russia Hyo-Soo Kim, MD, PhD Seoul National University Hospital Seoul, South Korea Young-Hak Kim, MD, PhD Asan Medical Center Seoul, South Korea Takeshi Kimura, MD Kyoto University Hospital Sakyo-ku, Japan Franz X. Kleber, MD Charité University Medicine Berlin Berlin, Germany Young-Guk Ko, MD Yonsei University Seoul, South Korea Karel T. Koch, MD, PhD Academic Medical Center Amsterdam Amsterdam, The Netherlands Akihiro Koide, PhD Pharmaceuticals and Medical Devices Agency Tokyo, Japan Javad Kojuri, MD, PhD Nemazee Hospital Shiraz, Iran Bon-Kwon Koo, MD, PhD Seoul National University Hospital Seoul, South Korea Jacques J. Koolen, MD, PhD Catharina Hospital Eindhoven, The Netherlands Ran Kornowski, MD Rabin Medical Center Petach Tikva, Israel Jan Kovac, MD University Hospital of Leicester Leicester, United Kingdom Hans Krankenberg, MD Angiologikum Hamburg Hamburg, Germany Tomislav Krcmar, MD Sisters of Mercy University Hospital Zagreb, Croatia Po-Ming Ku, MD Chi-Mei Medical Center Yong-kang City, Taiwan Prathap Kumar, MD Meditrina Hospital Kerala, India Sreenivas Arramraju Kumar, MD, DM CARE Hospitals Hyderabad, India Vijayalakshmi Kunadian, MBBS, MD Freeman Hospital Newcastle upon Tyne, United Kingdom Vincent On-Hing Kwok, MD Hong Kong Sanatorium and Hospital Hong Kong, China Jean-Claude Laborde, MD St George s Hospital London, United Kingdom Antoine Lafont, MD Hôpital European Georges Pompidou Paris, France Yat-Yin Lam, MD Chinese University of Hong Kong Hong Kong, China Rudiger Lange, MD, PhD German Heart Center Munich Munich, Germany Jens Flensted Lassen, MD, PhD Aarhus University Hospital Aarhus, Denmark Azeem Latib, MB, BCh EMO-GVM Centro Cuore Columbus Milan, Italy Sandra Lauck, PhD St. Paul s Hospital Vancouver, Canada Michel R. Le May, MD University of Ottawa Heart Institute Ottawa, Canada Guy LeClerc, MD Centre Hospital Universitaire de Montreal Montreal, Canada Michael Kang-Yin Lee, MBBS Queen Elizabeth Hospital Kowloon, China Wen-Lieng Lee, MD Taichung Veterans General Hospital Taichung City, Taiwan Thierry Lefevre, MD Institut Hospitalier Jacques Cartier Massy, France Jorge H. Leguizamon, MD Argentine Society of Interventional Cardiology Buenos Aires, Argentina Jacek Legutko, MD, PhD Jagiellonian University Kraków, Poland Jonathon A. Leipsic, MD St. Paul s Hospital Vancouver, Canada Jose L. Leiva-Pons, MD Hospital Central San Luis Potosi, Mexico Jonathan Leor, MD Sheba Medical Center Tel-Hashomer, Israel Maciej Lesiak, MD, PhD University Hospital Poznan, Poland Eli I. Lev, MD Rabin Medical Center Petach Tikva, Israel Thosaphol Limpijankit, MD Ramathibodi Hospital Bangkok, Thailand Rikard B.A. Linder, MD, PhD Danderyds University Hospital Stockholm, Sweden Axel Linke, MD University of Leipzig Heart Center Leipzig, Germany Jian Liu, MD Peking University People s Hospital Beijing, China Xuebo Liu, MD East Hospital, Tongji University Shanghai, China Hugo F. Londero, MD Sanatorio Allende-Cordoba Cordoba, Argentina Chaim S. Lotan, MD Hadassah University Hospital Jerusalem, Israel Yves R. Louvard, MD Institut Hospitalier Jacques Cartier Massy, France Michael P. Love, MB, ChB, MD Queen Elizabeth II Health Sciences Centre Halifax, Canada Shuzheng Lu, MD Beijing An Zhen Hospital Beijing, China George Lutter, MD, PhD University Hospital Schleswig-Holstein Kiel, Germany Philip A. MacCarthy, BSc, PhD, FRCP King s College Hospital London, United Kingdom Sumaira Macdonald, MD, PhD Freeman Hospital Newcastle upon Tyne, United Kingdom Lindsay S. Machan, MD Vancouver Hospital and Health Sciences Center Vancouver, Canada Ayman Magd, MD Azhar University Cairo, Egypt Ahmed Magdy, MD National Heart Institute in Cairo Cairo, Egypt Felix Mahfoud, MD Klinik für Innere Medizin III Homburg/Saar, Germany

39 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics Francesco Maisano, MD San Raffaele Hospital Milan, Italy Jose Armando Mangione, MD BeneficÍncia Portuguesa Hospital São Paulo, Brazil Ganesh Manoharan, MD Royal Victoria Hospital Belfast, United Kingdom Marco Manzi, MD Policlinico Abano Terme Abano Terme, Italy Kristina Maric, MD Working Groups on Interventional Cardiology for Croatia, Greece, and Serbia Zagreb, Croatia Majid Naghibzadeh Mashayekh, MD Mehrad Hospital Tehran, Iran Martin Mates, PhD Na Homolce Hospital Prague, Czech Republic Samuel K. Mathew, MD, DM Apollo Hospitals Chennai, India Detlef G. Mathey, MD Hamburg University Cardiovascular Center Hamburg, Germany Klaus D. Mathias, MD Radiologische Klinik Dortmund, Germany Margaret B. McEntegart, MD Golden Jubilee National Hospital Glasgow, United Kingdom Julinda Mehilli, MD Deutsches Herzzentrum und Medizinische Klinik der Technischen Universitat München Munich, Germany Shamir R. Mehta, MD, MSc Hamilton Health Sciences Hamilton, Canada Bernhard Meier, MD Swiss Cardiovascular Center Bern Bern, Switzerland Oscar A. Mendiz, MD Fundacion Favaloro Buenos Aires, Argentina Maurizio Menichelli, MD Spaziani Hospital Frosinone Frosinone, Italy Ian T. Meredith, MBBS, PhD Monash Medical Centre Clayton Melbourne, Australia José Alfredo Merino Rajme, MD Centro Medico Nacional 20 de Noviembre Mexico City, Mexico Francesco Meucci, MD Azienda Ospedaliero-Universitaria Careggi Firenze Firenze, Italy Erich Minar, MD Medical University Vienna Vienna, Austria Sundeep Mishra, MD, DM All India Institute of Medical Sciences New Delhi, India Kazuaki Mitsudo, MD Kurashiki Central Hospital Kurashiki, Japan Shunichi Miyazaki, MD, PhD Kinki University Osaka, Japan Neil E. Moat, MD Royal Brompton Hospital London, United Kingdom Helge Moellmann, MD Kerckhoff Heart Center Bad Nauheim, Germany Friedrich W. Mohr, MD, PhD Heart Center Leipzig Leipzig, Germany Victor P. Moles, MD Cardiology Center, University Hospital Santa Fe, Argentina Gilles Montalescot, MD, PhD Centre Hospitalier Universitaire Pitié-Salpêtrière Paris, France Marie-Angele Morel, BSc Cardialysis B.V. Rotterdam, The Netherlands Jose Gomez Moreno, MD Cardiovascular Institute of Missions Misiones, Argentina Jacques Moret, MD, PHD Beaujon University Hospital Clichy, France Marie-Claude Morice, MD Institut Cardiovasculaire Paris Sud Massy, France Harald G.W. Mudra, MD Klinikum Neuperlach Munich, Germany Ajit Mullasari, MD, DM, DNB, FRCP Madras Medical Mission Hospital Chennai, India David W.M. Muller, MBBS, MD St. Vincent s Hospital Darlinghurst, Australia Brad I. Munt, MD St. Paul s Hospital Vancouver, Canada Toshiya Muramatsu, MD Saiseikai Yokohama-City Eastern Hospital Yokohama, Japan Aung Myat, BSc, MBBS, MRCP BHF Centre of Research Excellence, St Thomas Hospital London, United Kingdom Christoph K. Naber, MD, PhD Contilia Heart and Vascular Center Essen, Germany Masato Nakamura, MD Toho University Ohashi Medical Center Tokyo, Japan Sunao Nakamura, MD, PhD New Tokyo Hospital Chiba, Japan Koichi Nakao, MD Saiseikai Kumamoto Hospital Cardiovascular Center Kumamoto, Japan Massimo Napodano, MD Padova University Hospital Padova, Italy Muda Nasir, MD Institut Jantung Negara Kuala Lumpur, Malaysia Kenya Nasu, MD Toyohashi Heart Center Toyohashi, Japan Franz-Josef Neumann, MD Universitäts-Herzzentrum Freibrug Bad Krozingen Bad Krozingen, Germany Martin Ng, MD, PhD Royal Prince Alfred Hospital Sydney, Australia Georg Nickenig, MD University of Bonn Bonn, Germany Matti Jaakko Niemela, MD University of Oulu Oulu, Finland Christoph A. Nienaber, MD, PhD University of Rostock Rostock, Germany Eugenia Nikolsky, MD, PhD Rambam Medical Center Haifa, Israel Stephane Noble, MD Hôpitaux Universitaires de Genève Geneva, Switzerland James Nolan, MD, MB, ChB University Hospital North Staffordshire Stoke on Trent, United Kingdom Andrzej J. Ochala, MD University Hospital Katowice, Poland Masahiko Ochiai, MD, PhD Showa University Northern Yokohama Hospital Kanagawa, Japan Takao Ohki, MD, PhD Jikei University School of Medicine Tokyo, Japan Keith G. Oldroyd, MD West of Scotland Regional Heart and Lung Centre Glasgow, United Kingdom Goran K. Olivecrona, MD, PhD Skane University Hospital Lund, Sweden Gustavo V.L. Olivotti, MD Hospital BeneficÍncia Portuguesa São Paulo, Brazil Elmir Omerovic, MD, PhD Sahlgrenska Universtiy Hospital Guldheden, Sweden Eustaquio Maria Onorato, MD Clinica Montevergine, Mercogliano Gussago, Italy Yoshinobu Onuma, MD Thoraxcenter, Erasmus Medical Center Rotterdam, The Netherlands John A. Ormiston, MB, ChB Mercy and Auckland City Hospitals Auckland, New Zealand Alexander Grigorievich Osiev, MD State Research Institute of Circulation Pathology Novosibirsk, Russia Miodrag C. Ostojic, MD, PhD Clinical Centre of Serbia Belgrade, Serbia and Montenegro T. Oude Ophuis, MD Canisius Hospital Nijmegen, The Netherlands Tullio Palmerini, MD Policlinico S. Orsola Bologna, Italy Manotosh Panja, MD, DM Belle Vue Clinic Kolkata, India George Parcharidis, MD AHEPA University Hospital Thessaloniki, Greece Keyur H. Parikh, MD Care Institute Medical Sciences Ahmedabad, India Jai-Wun Park, MD Asklepios Kliniken Hamburg, Germany Seung-Jung Park, MD, PhD Asan Medical Center Seoul, South Korea Tejas Patel, MD, DM APEX Heart Institute Ahmedabad, India Lekha R.A. Pathak, MD, DM, FRCP Nanavati Hospital, Nanavati Heart Institute Mumbai, India Carlos Pedra, MD, PhD Instituto Dante Pazzanese de Cardiologia São Paulo, Brazil Marco A. Perin, MD, PhD Hospital Albert Einstein São Paulo, Brazil Anna Sonia Petronio, MD Ospedale di Cisanello Pisa, Italy Petur Petursson, MD, PhD Sahlgrenska University Hospital Gothenburg, Sweden Nicolo Piazza, MD Cardialysis Montreal, Canada Philippe Pibarot, DVM, PhD Quebec Heart and Lung Institute Quebec City, Canada Jan J. Piek, MD University of Amsterdam Amsterdam, The Netherlands Mikko Pietila, MD, PhD Turku University Hospital Turku, Finland Nico H.J. Pijls, MD, PhD Catharina Hospital Eindhoven, The Netherlands Hrvoje Pintaric, MD, PhD University Hospital Sestre Milosrdnice Zagreb, Croatia Ruben A. Piraino, MD Sanatorio Plaza Rosario, Argentina Sunil Pisharody, MD Kerala University Malapuram, India 37

40 International Faculty David Planer, MD Hebrew University-Hadassah Medical Center Jerusalem, Israel Stuart J. Pocock, PhD London School of Hygiene and Tropical Medicine London, United Kingdom Antonio Pocovi, MD Sanatorio San Lucas Buenos Aires, Argentina Piotr Ponikowski, MD, PhD Medical University, Military Hospital Wroclaw, Poland Suzanne Marie Pourbaix, MD CHR Citadelle Liege, Belgium Francesco Prati, MD San Giovanni Hospital Rome, Italy Jerzy Pregowski, MD Institute of Cardiology Warsaw, Poland Alexey Protopopov, MD Krasnoyarsk Regional Cardiovascular Center Krasnoyarsk, Russia Jie Qian, MD Fu Wai Hospital Beijing, China Shubin Qiao, MD Beijing Fuwai Hospital Beijing, China Hany Ragy, MD National Heart Institute Cairo, Egypt Afzalur Rahman, MD, PhD National Institute of Cardiovascular Diseases Dhaka, Bangladesh Angelo Ramondo, MD Centro Studi di Cardiologia Invasiva SRL Bassano del Grappa, Italy Vishal Rastogi, MD Fortis Escorts Heart Institute New Delhi, India Sudhir Rathore, MD St Georges Hospital London, United Kingdom Saumitra Ray, MD Cardiological Society of India Kolkata, India Krzysztof W. Reczuch, MD, PhD Military Hospital Wroclaw Wroclaw, Poland Ashraf Reda, MD Menoufiya University Cairo, Egypt Gokul M. Reddy, MD Consultant Care/ACVS Core Committee Hyderabad, India Simon Redwood, MD St Thomas Hospital London, United Kingdom Evelyn S. Regar, MD, PhD Erasmus Medical Center Rotterdam, The Netherlands Bernhard Reimers, MD Ospedale di Mirano Mirano, Italy Expedito E. Ribeiro, MD, PhD The Heart Institute/University of São Paulo São Paulo, Brazil Stéphane Rinfret, MD, SM Quebec Heart and Lung Institute Quebec City, Canada Josep Rodes-Cabau, MD Quebec Heart and Lung Institute/ Laval University Quebec, Canada Alfredo Rodriguez, MD, PhD Sanatorio Otamendi Buenos Aires, Argentina Ariel Roguin, MD, PhD Rambam Healt Care Campus Haifa, Israel Hannu Romppanen, MD Kuopio University Hospital Kuopio, Finland Mohd Ali Rosli, MD National Heart Institute Kuala Lumpur, Malaysia Jamil Abdalla Saad, MD Fundação, Felisse Rosso Belo Horizonte, Brazil Manel Sabate, MD, PhD Thorax Institute, Hospital Clinic Barcelona, Spain Stefan Sack, MD Klinikum Schwabing Munich, Germany Carlos Alberto Sada Beneficencia Portuguesa de São Paulo São Paulo, Brazil Shigeru Saito, MD Shonan Kamakura General Hospital Kanagawa, Japan Negar Salehi, MD Shaheed Rajaei Cardiovascular Tehran, Iran Luigi Salemme, MD Montevergine Clinic Naples, Italy Giuseppe M. Sangiorgi, MD University of Rome tor Vergata Rome, Italy Gennaro Sardella, MD Policlinico Umberto I University Rome, Italy Rogerio Sarmento-Leite, MD, PhD Instituto de Cardiologia do Rio Grande do Sul Porto Alegre, Brazil Erick Schampaert, MD Hopital du Sacre-Coeur de Montreal Montreal, Canada Dierk Scheinert, MD Park-Krankenhaus Leipzig Leipzig, Germany Bruno Scheller, MD Universitätsklinikum des Saarlandes Homburg, Germany Markus P. Schlaich, MD Baker IDI Heart and Diabetes Institute Melbourne, Australia Andrej Schmidt, MD University of Leipzig-Heartcenter Leipzig, Germany Joachim Schofer, MD Hamburg University Cardiovascular Center Hamburg, Germany Gerhard C. Schuler, MD Herzzentrum Leipzig Leipzig, Germany Amit Segev, MD Chaim Sheba Medical Center Tel Hashomer, Israel Jacques Seguin, MD CoreValve Paris, France Philippe Selleslagh, MD ZOL Genk Genk, Belgium Sayan Sen, MBBS National Heart and Lung Institute London, United Kingdom Martinez Sepulveda, MD Chile Patrick W. Serruys, MD, PhD Thoraxcenter Rotterdam, The Netherlands Ashok Seth, DSc Escorts Heart Institute and Research Centre New Delhi, India Georgios Sianos, MD, PhD AHEPA University Hospital Thessaloniki, Greece Dirk Sibbing, MD Deutsches Herzzentrum München Munich, Germany Peter Sick, MD Krankenhaus Barmherzige Brüder Regensburg Germany Horst Sievert, MD, PhD CardioVascular Center Frankfurt, Sankt Katharinen Frankfurt, Germany Ulrich Sigwart, MD University of Geneva Geneva, Switzerland Jozica Sikic, MD University Hospital Zagreb, Croatia Sigmund Silber, MD Heart Center at the Isar Munich, Germany Kui-Hian Sim, MD University Malaysia Sarawak, Malaysia Tabassome Simon, MD, PhD Hospital St. Antoine UPMC Paris, France Ajay Radheshyam Sinhal, MBBS, MD, DM, FRACP Flinders Medical Centre Adelaide, Australia Tomislav Sipic, MD Magdalena Clinic for Cardiovascular Diseases Krapinske Toplice, Croatia Dimytri Siqueira, MD, PhD Instituto Dante Pazzanese de Cardiologia São Paulo, Brazil Elliot Smith, MD Queen Mary University of London London, United Kingdom Peter C. Smits, MD, PhD Maasstad Ziekenhuis Rotterdam, The Netherlands David Smyth, MD Christchurch Hospital Christchurch, New Zealand Mohamed Sobhy, MD Alexandria University Alexandria, Egypt Lars Sondergaard, MD Rigshospitalet-Copenhagen University Hospital Copenhagen, Denmark Giovanni Sorropago, MD Clinica Montevergine Avellino, Italy Konstantinos Spargias, MD, PhD Hygeia Hospital Athens, Greece James Spratt, BSc, MD Forth Valley Royal Hospital Larbert, United Kingdom Eugenio Stabile, MD, PhD Clinica Montevergine Mercogliano, Italy Rod H. Stables, MA, DM Liverpool Heart and Chest Hospital Liverpool, United Kingdom Josef Stasek, MD, PhD University Hospital Hradec Kralove Hradec Kralove, Czech Republic Christodoulos I. Stefanadis, MD University of Athens Athens, Greece Philippe Gabriel Steg, MD Groupe Hospitalier Bichat - Claude Bernard Paris, France Terje K. Steigen, MD, PhD, FESC University Hospital of Northern Norway Tromso, Norway Pieter R. Stella, MD, PhD University Medical Center Utrecht Utrecht, The Netherlands Roman Stipal, MD University Hospital Olomouc, Czech Republic Martin G. Stoel, MD Medisch Spectrum Twente Enschede, The Netherlands Bradley H. Strauss, MD, PhD Sunnybrook Health Sciences Center Toronto, Canada Maja Strozzi, MD Zagreb University Hospital Center Zagreb, Croatia Daniel Suerder, MD Fondazione Cardiocentro Ticino Lugano, Switzerland 38

41 Satoru Sumitsuji, MD Osaka University Suita, Japan Gabor Sutsch, MD HerzZentrum Hirslanden Zurich, Switzerland Maarten J. Suttorp, MD, PhD St. Antonius Hospital Nieuwegein, The Netherlands Tomohisa Tada, MD Deutsches Herzzentrum Munich, ISAR Center Munich, Germany David Taggart, MD, PhD John Radcliffe Hospital Oxford, United Kingdom Corrado Tamburino, MD, PhD Ferrarotto Hospital Catania, Italy Huay Cheem Tan, MD National University Heart Centre Singapore Jean-François Tanguay, MD Montreal Heart Institute Montreal, Canada Koen Teeuwen, MD St. Antonius Hospital Nieuwegein, The Netherlands Gunnar Tepe, MD Hospital of Rosenheim Rosenheim, Germany Per Thayssen, MD Odense University Hospital Odense, Denmark Holger Thiele, MD University of Leipzig Heart Center Leipzig, Germany Martyn R. Thomas, MD St. Thomas Hospital London, United Kingdom Leif Thuesen, MD Aarhus University Hospital Aarhus, Denmark Pim A.L. Tonino, MD Catharina Hospital Eindhoven, The Netherlands Ernesto M. Torresani, MD Sanatorio Modelo Quilmes Buenos Aires, Argentina Konstantinos Toutouzas, MD Athens Medical School Athens, Greece Hendrik Treede, MD University Heart Center Hamburg Hamburg, Germany Chuen-Den Tseng, MD, PhD National Taiwan University Hospital Taipei, Taiwan Konstantinos P. Tsioufis, MD First Cardiology Clinic, University of Athens, Hippokration Hospital Athens, Greece Etsuo Tsuchikane, MD, PhD Toyohashi Heart Center Toyohashi, Japan Jorge Tuma, MD CENCOR / Maison de Sante Clinic Lima, Peru Shiro Uemura, MD, PhD Nara Medical University Kashihara, Japan Takafumi Ueno, MD, PhD Kurume University Hospital Fukuoka, Japan Philip M. Urban, MD La Tour Hospital Geneva, Switzerland Gian Paolo Ussia, MD Ferrarotto Hospital Catania, Italy Alec S. Vahanian, MD Hôpital Bichat Paris, France Marco Valgimigli, MD, PhD University Hospital of Ferrara, Cardiovasuclar Institute Ferrara, Italy Tim P. van de Hoef, MD Academic Medical Center Amsterdam, The Netherlands Frans Van de Werf, MD University of Leuven Leuven, Belgium René J. van der Schaaf, MD, PhD Onze Lieve Vrouwe Gasthuis Amsterdam, The Netherlands Antonius F.W. van der Steen, PhD Erasmus Medical Center Rotterdam, The Netherlands Robert-Jan van Geuns, MD Erasmus University Rotterdam Rotterdam, The Netherlands Isabelle Van Herzeele, MD, PhD University Hospital Ghent Ghent, Belgium Glenn Van Langenhove, MD, PhD, MBA Middelheim Hospital Antwerp Antwerpen, Belgium Nicolas M. van Mieghem, MD Erasmus Medical Center Rotterdam, The Netherlands Freek W.A. Verheugt, MD Onze Lieve Vrouwe Gasthuis Amsterdam, The Netherlands Stefan Verheye, MD, PhD Antwerp Cardiovascular Institute, Middleheim Hospital Antwerp, Belgium Paul Vermeersch, MD, PhD AZ Middelheim Hove, Belgium Josef Veselka, MD, PhD Motol University Hospital Prague, Czech Republic Luis R. Virgen Carrillo, MD, PhD Hospital Angeles del Carmen Guadalajara, Mexico Clemens von Birgelen, MD, PhD Thoraxcentrum Twente Enschede, The Netherlands Jeroen Vos, MD Amphia Hospital Breda Breda, The Netherlands Pascal Vranckx, MD Hartcentrum Hasselt Hasselt, Belgium Marco V. Wainstein, MD, DSc Hospital de Clinicas de Porto Alegre and Hospital Moinhos de Vento Porto Alegre, Brazil Simon Walsh, MD, MRCP Belfast Trust Belfast, United Kingdom Darren L. Walters, MBBS, MPhil The Prince Charles Hospital Brisbane, Australia Thomas Walther, MD Kerckhoff Klinik Bad Nauheim Bad Nauheim, Germany Haichang Wang, MD Xijing Hospital Xi an, China Jian an Wang, MD, PhD Second Affiliated Hospital, Zhejiang University School of Medicine Hangzhou, China Lefeng Wang, MD Beijing Chaoyang Hospital Beijing, China Weimin Wang, MD Peking University People s Hospital Beijing, China John G. Webb, MD St. Paul s Hospital Vancouver, Canada Mark W.I. Webster, MB, ChB Auckland City Hospital Auckland, New Zealand Daniel Weilenmann, MD Cantonal Hospital St. Gallen St. Gallen, Switzerland Francis C. Wells, MD Papworth Hospital Cambridge, United Kingdom Robert C. Welsh, MD Mazankowski Alberta Heart Institute Edmonton, Canada Peter Wenaweser, MD University Hospital Bern Bern, Switzerland Gerald S. Werner, MD, PhD Klinikum Darmstadt Darmstadt, Germany Harvey D. White, DSc Green Lane Cardiovascular Service, Auckland City Hospital Auckland, New Zealand Stephan Windecker, MD Swiss Cardiovascular Center Bern Bern, Switzerland Adam Witkowski, MD, PhD Institute of Cardiology Warsaw, Poland Bernhard Witzenbichler, MD Charité University of Medicine Berlin Berlin, Germany Jochen Wöhrle, MD University Hospital Ulm Ulm, Germany Wojciech Wojakowski, MD, PhD Third Division of Cardiology Katowice, Poland David A. Wood, MD St. Paul s and Vancouver General Hospital Vancouver, Canada Stephen G. Worthley, PhD Royal Adelaide Hospital Adelaide, Australia Nina C. Wunderlich, MD University Hospital Mainz Mainz, Germany Bo Xu, MD Fu Wai Hospital Beijing, China Masahisa Yamane, MD Sayama Hospital Sayama City, Japan Hongbing Yan, MD, PhD Cardiovascular Institute and Fu Wai Hospital Beijing, China Joo-Young Yang, MD NHIC Ilsan Hospital Koyangshi, South Korea Yuejin Yang, MD, PhD Cardiovascular Institute and Fu Wai Hospital Beijing, China Uri Yaron, PhD Biosense- Webster Tirat Carmel, Israel Jian Ye, MD St. Paul s Hospital Vancouver, Canada Antti Ylitalo, MD Satakunta Central Hospital Pori, Finland Michael Yonash, MD Kaplan Medical Center Ramat Gan, Israel Amr Mahmoud Zaki, MD Alexandria University Alexandria, Egypt Robaayah Zambahari, MBBS National Heart Institute Kuala Lumpur, Malaysia Andreas M. Zeiher, MD University Hospital Medical Center Frankfurt, Germany Michael Zelizko, MD, PhD Clinic of Cardiology IKEM Praha, Czech Republic Thomas Zeller, MD Herzzentrum Freiburg-Bad Krozingen Bad Kronzingen, Germany Bin Zhang, MD Guangdong General Hospital Guangdong Cardiovascular Institute Guangzhou, China Qi Zhang, PhD Shanghai Ruijin Hospital Shanghai, China Yujie Zhou, MD, PhD Beijing Anzhen Hospital Beijing, China 39

42 TCT Advisory Faculty Siddamsetty Abbaiah, DM Atul Abhyankar, DM D.G. Adwani, MD Rahman Afzalur, MD D.K. Agarwal, MD Praveer Agarwal, MD, DM Sanjeev Agarwal, MD, DM Rajiv Agarwal, MD, DM Rajiv Agarwal, MD Sunil Ishwarchand Agarwal, MD, DNB Desai Ajit, MD Valiyakath Ali Faizal, MD, DM Banerjee Amal, MD Dhall Anil, MD Katdare Anil, MD Shah Anupam, MD Singhal Anurag, MD, DM Manjunath Anusuya, MD Kochar Arun, MD, DM Das Arvind, MD Madhu Asawa, MD Ashraf Ashraf, MD Safiya Manzil Ashraf, MD, DM B. Ashalatha, DM Mehta Ashwin, MD Lakshmi Narayanan Aswathaman, MD B. Ramesh Babu, MD, DM Raghuraman Bagirath, MD V.K. Bahl, MD Narasimha Bhatta Balakrishnan, MD, DM Singh Balbir, MD Gopalakrishna Sudhakar Balijepalli, MD Parthasarathi Banerjee, DM Karun Behal, DM Anupam Bhambani, MD Naveen Bhamri, MD, DM Suman Bhandari, MD, DM Narayan M. Bhat, MD, DM Kinjal Bhatt, MD, DNB Jagadesa Subramanya Bhuvaneswaran, MD, DM Rajneesh Calton, DM Shilpesh Champaneria, DNB Subash Chandra, MD, DM Nishith Chandra, MD Moorthy Chandran, MD Mahantesh Rachayya Charantimath, MD Virendra C. Chauhan, MD Chandrakant Chavan, MD Kamaldeep Chawla, DNB Bino Benjamin Chizhuthanikkal, MD Manjunath Cholenally, MD Nagendra Singh Chouhan, MD, DNB Issac Cibi, MD Suresh Davis, MD Davidson Deepak, MD, DM Saha Deepak, MD Mandar Dattatraya Deo, MD, PhD Aseem Dhal, MD, DM Aseem Dhall, MD Aniruddha Dharmadhikari, MD Krishnakumar Dhoot, MD Sharma Dhruva, MD Ratnani Dilip, MD Prabhakar A. Dorairaj, MBBS Vaidiyanathan Doraiswamy, MD, DM Jaskaran Singh Dugal, MD, MNAMS, DM S.K. Dwivedi, MD Rajeev Edakutty, MD G. Keshavamurthy, MD, DM, DNB Aniket Gadre, MD Dalbir Singh Gambhir, MD Shah Atit Gaurang, MD Oomen K. George, MD, DM Thomas George, DM Harpreet Singh Gilhotra, DM Anand Gnanaraj, MD, DM, FNB Pravin Kumar Goel, MD Reddy Gokul, MD Nagendra Prasad Golla, MD Kondal Rao Gollamandala, MD Sreenivas Colanakuduru Gopal, MD Elangovan Govindarajan, MD B.K. Goyal, MD Purvez Keki Grant, MD Anil Grover, MD Ramesh Gudapati, MD Surya Prakash Gulla, MD Suvir Gupta, DM Kandaswami Gurunath, MD Haridas Haridas, MD Sanadhya Harish, MD P.K. Hazra, MD Behera Hemanta MD M.S. Hiremath, MD Dev Indranil, MD Biju Chandy Isaac, MD Prakash Jain, MD Sharad Jain, MD Neeraj Jain, MD, DM Vidhut Kumar Jain, MD Ezhilan Janakiraman, MD Satej Janorkar, MD Rakesh Kumar Jaswal, DM Kannan Bawaramalingam Jawaharlal, MD T.G. Jayakumar, MD Jayanna Jayanna, MD Prajapati Jayesh, MD D.K. Jhamb, MD Rakesh C. Jindal, DM Abhijeet Joshi, MD Sreemannarayana Jujjuru, MD Kannan Jyothi, MD Nitin Kabra, MD Jain.T. Kallarakkal, MD B.C. Kalmath, MD Ghanashyam R. Kane, MD, DM Anil Saleem Kanhirala, MD Das Mrinal Kanti, MD Deepak Kapila, DM Aditya Kapoor, MD Atul Kasliwal, DM Upendra Kaul, MD Murthy Keshav, MD Javed Ali Khan, MD Uday Khanolkar, MD Rajeev Kumar Khare, MD K.S. Kishore, MD Damodara Rao Kodem, MD Yogesh Amrutlal Kothari, MD, DNB Asokan Parayoru Kottayil, MD Koduru Gopala Krishna, DM Lanka Satya Rama Krishna, MD, DM Vinod Krishnan, MD Abhay Kumar, MD Agarwal Kishna Kumar, MD Ajith Kumar, MD Badhan Brajesh Kumar, MD, DM Baruah Dibya Kumar, MD, DM Goyal Gajinder Kumar, MD, DM Ganesh Kumar, MD, DM Malhotra Ashish Kumar, MD Yadav Mukesh Kumar, MD, DM Nikhil Kumar, MD, DM Prabhat Kumar, MD Rajeeve Kumar, MD R. Shiva Kumar, MD Renju Kumar, MD Shiva Kumar, MD Viveka Kumar, MD, DM Kumaran Sunitha Kumari, MD, DM Yusuf A. Kumble, MD, DM, DNB Subrata Lahiri, MD, DM Purushotam Lal, MD, DM Tilak Kishor Lall, MD Krishna Lanka, MD Pathak Lekha, MD Amal Louis, MD, DM Ali Mabboob, MD C. N. Makhale, MD Ajay Kumar Umakant Mahajan, MD Ashok Malpani, MD Panja Manatosh, MD Bagur Venkataramaiah Manjunatha, MD, DM Rajan Joseph Manjuran, MD Anil Kumar Mannambeth, MD Kumar Manoj, MD Ashraf Safiya Manzil, MD Viney Mathavan, MD Thomas Mathew, MD Chandra Bhan Meena, MD Haresh Mehta, MD, DNB Ajit R. Menon, MD, DM Bishav Mohan, DM Asawa Madhusudhan Mohanlal, MD, DM S.C. Mondal, MD Bishav Mohan, MD, DM Behara Mrintunjay, MD Omer Hasan Mustafa, DM A.C. Nagamani, MD Venugopal Krishnan Nair, MD Sinha Nakul, MD Ganesan Nambirajan, MD Panigrahi Nanda Kumar, MD Hemant Narayan, DM Srichandran Lakshmi Narayanan, MD Padmanaban Narayanan, MD, DM Pamnani Naresh, MD Ranjit Nath, MD, DM Mathew Naveen, MD P.D. Nigam, MD, DM Tripathi Nitynand, MD Vishnu Prabhu Oonu Rajan, MD Raveendran Pachakkoottathil, MD Balaji Pakshirajan, MD Murali Sankar Reddy Palchuri, MD Mahesh Babu Panchanathan, MD Neeraj Pandit, MD, DM Nanda Kishore Panigrahi, DM Jagdish Parikh, MD, DM Mukesh Parikh, MD Nikhil Parikh, MD Tejas Patel, MD Piyush Patel, MD Saurin Patel, MD Piyush Patel, MD, FACC Balagopal Jayagopal Pathiyil, MD Rahul Raosaheb Patil, MD, DNB Sachin Narendra Patil, MD, DNB Venkata Surya Sambhu Patimalla, MD U. Patnaik, MD A.C. Perierra, MD M.G. Pillai, MD Brian Pinto, MD Sunil Pisharody, MD Pawan Poddar, MD Anil Potdar, MD Kawthekar Girish Prabhakar, MD Halkatti Prabhu, MD Sitaram Manthri Pragada, MD Sharma Ved Prakash, MD, DM Niraj Prasad, MD Nyayadish Prasanna, MD Charanjit Singh Pruthi, MD Charanjit Singh Pruthi, MD Lakkaraj Rajasekhar, MD Deshmukh Rajendra, MD, DM Khare Rajiv, MD Arora Rakesh, MD Chengala Damodara Ramakrishna, MD, DM Balakrishnan Ramamurthy, MD, DM Puri Raman, MD Gudapati Ramesh, DM Ramalingam Rangarajan, MD Alok Ranjan, DM Anand Rao, MD, DNB Vithala Surya Prakasa Rao, DM J. Shivkumar Rao, MD Rajeev Rathi, MD, DM Parvathareddy Krishna Malakonda Reddy, MD, DM Ravindra Nath Reddy, MD Roopa Reddy, MD Sharat Reddy, MD Vinod Revankar, MD Gupta Ripen, MD Mody Rohit, MD, DM Sanjeeb Roy, DM David Rozario, DM John Satish Rudrapogu, MD Amit Sambare, MD Manjinder Singh Sandhu, DM Porwal Sanjay, MD Murugan Sankaranarayanan, MD Rakesh Sapra, MD, DM Vaidya Satish, MD, DM Devnani Satish, MD Routray Satyanarayan, DM Ashok Seth, MD, DM Selvamani Sethuraman, MD Bhupesh Shah, MD, DNB Jay Shah, DM Om Shankar, MD Gautam Sharma, MD Sanjeev Kumar Sharma, DM Anil Sharma, MD Chetan Sharma, MD Amit Sharma, MD Jagdish Kumar Sharma, MD Shashi Mohan Sharma, MD B.K. Shastry, MD Joshi Radhey Shyam, MD Gurappa Gojanur Shetty, MD, DM Srikanth Shetty, MD Dutta Shuvo, MD Mukerjee Siddharth, MD, DM Prabhu Dayal Singh, MD Harnoor Singh, MD Amar Singhal, MD, DM Ramanand Sinha, MD Ramanand Sinha, DM Nanda Kumar Sivasankar, MD Trivedi Skand, MD Kothari Snehal, MD Chozhakkat Somanathan, MD, DM S.L. Soneji, MD Madhu Sreedharan, DM P. Sreekala, MD Sangeetha Sreenivasan, MD N. Sridhara, MD, DM V.S. Srikanthan, MD Chandra Subhash, MD, DM Natarajan Subramanian, MD Kodangla Subramanyam, MD Chacko Sujith Thomas, MD Mantravadi Sai Sudhakar, MD, DM Sethi Sumeet, MD, DM Mishra Sundeep, MD Shyam Sunder, MD, DM Pujar Venkateshacharya Suresh, MD, DM Patted Suresh, MD Vijan Suresh, MD Krishnan Suresh, MD Pawan Suri, MD Ahmed Tamzeed, MD Mihir Tanna, MD, DNB Rajesh Thachathodiyl, MD Neelambujan Thanulingam, MD Sunil Thanvi, MD Saravanan Duraisamy Mohana Thiruvenkada, MD Alexander Thomas, MD P.L. Tiwari, MD Devasia Tom, MD S. Toshniwal, MD Haque M. Touhidul, MD Mahendra Prasad Tripathy, DM Rutvik Trivedi, DM Shailendra Trivedi, MD Kaushik Trivedi, MD Kalaichelvan Uthaikumar, MD Saha Uttam Kumar, MD, DM Asmit Vaidya, MD Kesava Vallabhapurapu, MD Das Vashisth, MD Karthik Vasudevan, MD, DM Bang Vijay, MD Purohit Bharat Vijay, MD, DM Chopra Vikas, MD Agrawal Vikas, MD Bhatia Vineet, MD Vijan Vinod, MD Muthukrishnan Viswanathan, MD Gurpreet Singh Wander, DM R.D. Yadave, MD, DM 40

43 United States Faculty The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics Keith D. Aaronson, MD University of Michigan Health System Ann Arbor, MI Lon S. Annest, MD, MBA BioVentrix San Ramon, CA Theodore A. Bass, MD University of Florida Health Science Center Jacksonville, FL Peter A. Brady, MB, ChB, MD Mayo Clinic Rochester, MN Amr Abbas, MD William Beaumont Hospital Royal Oak, MI J. Dawn Abbott, MD Rhode Island Hospital Providence, RI Alex Abou-Chebl, MD University of Louisville Stroke Center Louisville, KY William T. Abraham, MD Ohio State University Columbus, OH David H. Adams, MD Mount Sinai Medical Center Tayo A. Addo, MD UT Southwestern Clinical Heart Center Dallas, TX Ramesh K. Adiraju, MD RENU-CA Research Institute Bristol, PA Gorav Ailawadi, MD University of Virginia Charlottesville, VA Jodi Akin, VP Edwards Lifesciences Irvine, CA Ziad A. Ali, MD, DPhil Columbia University Medical Center Steven L. Almany, MD William Beaumont Hospital Boomfield Hills, MI Elissa Altin, MD NewYork-Presbyterian Hospital/ Columbia University Medical Center Yele Aluko, MD Presbyterian Cardiovascular Institute Charlotte, NC John A. Ambrose, MD UCSF Fresno Fresno, CA Zahid Amin, MBBS, MD Rush University Medical Center Chicago, IL Max Amor, MD Clinique Louis Pasteur Essey-les-Nancy, France Karthik Ananthasubramaniam, MD Henry Ford Health System Detroit, MI Mark B. Anderson, MD Albert Einstein Healthcare Network Philadelphia, PA Rick Anderson PTV Sciences Austin, TX Dominick J. Angiolillo, MD, PhD University of Florida-Shands Jacksonville, FL Brian H. Annex, MD University of Virginia Charlottesville, VA Gary M. Ansel, MD Riverside Methodist Hospital Columbus, OH Robert J. Applegate, MD Wake Forest University School of Medicine Winston-Salem, NC Michael Argenziano, MD NewYork-Presbyterian Hospital/ Columbia University Medical Center Herbert D. Aronow, MD, MPH St. Joseph Mercy Hospital Ypsilanti, MI Thomas Aversano, MD Johns Hopkins Medical Institutions Baltimore, MD Mohammad Ali Aziz-Sultan, MD University of Miami School of Medicine Miami, FL Ali Azizzadeh, MD University of Texas Houston Houston, TX Vasilis Babaliaros, MD Emory University School of Medicine Atlanta, GA Joseph D. Babb, MD East Carolina University School of Medicine Greenville, NC Usman Baber, MD Mount Sinai Medical Center Richard G. Bach, MD Barnes-Jewish Hospital St. Louis, MO Emile Bacha, MD Morgan Stanley Children s Hospital J. Michael Bacharach, MD, MPH North Central Heart Institute Sioux Falls, SD Steven R. Bailey, MD University of Texas Health Science Center at San Antonio San Antonio, TX Husam H. Balkhy, MD The Wisconsin Heart Hospital West Allis, WI Stephen Balter, PhD Columbia University Medical Center Sripal Bangalore, MD, MHA New York University School of Medicine Gust Bardy, MD University of Washington Carnation, WA Paddy Barrett, MD Scripps Translational Science Institute La Jolla, CA Eric R. Bates, MD University of Michigan Medical Center Ann Arbor, MI Mark C. Bates, MD CAMC Vascular Center of Excellence Charleston, WV James F. Benenati, MD Baptist Cardiac and Vascular Institute Miami, FL Nirat Beohar, MD Columbia University Division of Cardiology at Mount Sinai Medical Center Miami Beach, FL Daniel S. Berman, MD Cedars-Sinai Medical Center Los Angeles, CA Robert M. Bersin, MD Swedish Heart and Vascular Seattle, WA Stefan C. Bertog, MD University of Minnesota Medical School Minneapolis, MN Deepak L. Bhatt, MD, MPH VA Boston Healthcare System and Brigham and Women s Hospital Boston, MA Emma Birks, MBBS, PhD Jewish Hospital Transplant Center Louisville, KY John A. Bittl, MD Munroe Regional Medical Center Ocala, FL Tony Blank Boston Scientific Natick, MA James C. Blankenship, MD Geisinger Medical Center Danville, PA Peter C. Block, MD Emory University Hospital Atlanta, GA Ashley B. Boam, MSBE US Food and Drug Administration Silver Spring, MD William E. Boden, MD Stratton VA Medical Center Albany, NY Steven F. Bolling, MD University of Michigan Ann Arbor, MI Brett E. Bouma, PhD Massachusetts General Hospital Boston, MA Frank Bowen, MD The Cooper Health System Camden, NJ Bruce Bowers, MD Dallas Cardiovascular Specialists Dallas, TX Biykem Bozkurt, MD Michael E. DeBakey VA Medical Center Houston, TX Russell A. Brandwein, PA-C NewYork-Presbyterian Hospital/ Columbia University Medical Center Somjot S. Brar, MD Kaiser Permanente Los Angeles, CA Sorin J. Brener, MD New York Methodist Hospital Brooklyn, NY J. Matthew Brennan, MD, MPH Duke University Medical Center Durham, NC Bryan Brewster, MD Washington Hospital Center Washington, DC Perry Bridger, MHS Edwards Lifesciences Washington, DC Emmanouil S. Brilakis, MD, PhD VA North Texas Health Care System and UT Southwestern Medical Center Dallas, TX Ralph G. Brindis, MD, MPH Northern California Kaiser Permanente Oakland, CA Todd J. Brinton, MD Stanford University Medical Center Stanford, CA Bonnie Brown Saint Luke s Health System Kansas City, MO David Brown, MD Health Sciences Center Stony Brook, NY David L. Brown, MD The Heart Hospital Baylor Plano Dallas, TX Charles L. Brown III, MD Piedmont Healthcare Atlanta, GA Maurice Buchbinder, MD Foundation for Cardiovascular Medicine San Diego, CA Michael Buck Abbott Laboratories Abbott Park, IL M. Nicholas Burke, MD Minneapolis Heart Institute Foundation Minneapolis, MN Mark W. Burket, MD University of Toledo Medical Center Toledo, OH Daniel Burkhoff, MD, PhD CircuLite Saddle Brook, NJ Robert M. Califf, MD Duke Clinical Research Institute Durham, NC Louis A. Cannon, MD Northern Michigan Hospital Heart and Vascular Institute, Petoskey Cardiology Petoskey, MI 41

44 United States Faculty Daniel Canos, MPH US Food and Drug Administration Silver Spring, MD Ronald Caputo, MD SJH Cardiology Associates Syracuse, NY Blase A. Carabello, MD Veterans Affairs Medical Center Houston, TX John D. Carroll, MD University of Colorado Denver Aurora, CO Joseph P. Carrozza Jr, MD Steward St. Elizabeth s Medical Center Boston, MA Charles E. Chambers, MD Hershey Medical Center Hershey, PA Jeffrey Chambers, MD Metropolitan Cardiology Consultants Minneapolis, MN John P. Cheatham, MD Nationwide Children s Hospital Columbus, OH S. James Chen, PhD University of Colorado Hospital Aurora, CO James H. Chesebro, MD UMass Memorial Medical Center Worcester, MA Nicolas A.F. Chronos, MD Saint Joseph s Medical Group Atlanta, GA Sarah Clarke, MSN, NP Scripps Clinic and Research Foundation La Jolla, CA David J. Cohen, MD Saint Luke s Mid America Heart Institute Kansas City, MO Howard A. Cohen, MD Temple Universtiy Health System Philadelphia, PA Marc Cohen, MD Newark Beth Israel Medical Center Newark, NJ Mauricio G. Cohen, MD University of Miami Hospital Miami, FL William E. Cohn, MD Texas Heart Institute at St. Luke s Episcopal Hospital Houston, TX Michael B. Collins, MD NewYork-Presbyterian Hospital/ Columbia University Medical Center Tyrone J. Collins, MD Ochsner Clinic Foundation New Orleans, LA Anthony J. Comerota, MD Jobst Vascular Institute Toledo, OH Christopher J. Cooper, MD University of Toledo Medical Center Toledo, OH David Cormode, DPhil Perelman School of Medicine at the University of Pennsylvania Philadelphia, PN Nicola Corvaja, MD Stamford Hospital Stamford, CT Joseph N. Cosico, MA, CRA, CCRC Minneapolis Heart Institute Foundation Minneapolis, MN Marco A. Costa, MD, PhD University Hospitals Case Medical Center Cleveland, OH Robert J. Cottone OrbusNeich Medical Ft. Lauderdale, FL Todd D. Courtney, MS US Food and Drug Administration Silver Spring, MD Michael J. Cowley, MD Medical College of Virginia Richmond, VA David A. Cox, MD Lehigh Valley Hospital Bethlehem, PA Megan Coylewright, MD, MPH Mayo Clinic Rochester, MN Frank J. Criado, MD Medstar Union Memorial Hospital Baltimore, MD Gary Curtis, MD Los Altos, CA Jeptha P. Curtis, MD Yale University New Haven, CT Donald Cutlip, MD Beth Israel Deaconess Medical Center Boston, MA Michael D. Dake, MD Stanford University School of Medicine Stanford, CA Kate Dalton, MS, RD Columbia University Medical Center Richard C. Daly, MD Mayo Clinic Rochester, MN George D. Dangas, MD, PhD Mount Sinai Medical Center Tony Das, MD Presbyterian Heart Institute-Dallas Dallas, TX Harold L. Dauerman, MD Fletcher Allen Healthcare/ University of Vermont Burlington, VT Rajesh M. Dave, MD Holy Spirit Cardiovascular Institute, Holy Spirit Hospital Camp Hill, PA Charles J. Davidson, MD Northwestern Memorial Hospital Chicago, IL Michael J. Davidson, MD Brigham and Women s Hospital Boston, MA Jeff Davis, RRT, RCIS Edison State University Fort Myers, FL Keith D. Dawkins, MD Boston Scientific Natick, MA Anthony Dawson, MSN, RN NewYork-Presbyterian Hospital Larry S. Dean, MD University of Washington Regional Heart Center Seattle, WA Regina Deible, BSN, RN Suburban Hospital/ Johns Hopkins Medicine Bethesda, MD Augustin Delago, MD Albany Medical Center Albany, NY Anthony N. DeMaria, MD University of California, San Diego School of Medicine San Diego, CA Tony J. DeMartini, MD Prairie Cardiovascular Springfield, IL Harit Desai, DO DEBORAH Heart and Lung Center Brown Mills, NJ Todd M. Dewey, MD Medical City Dallas Dallas, TX Nabil Dib, MD, MSc, FACC Chandler Regional and Mercy Gilbert Medical Centers/Catholic Healthcare West Gilbert, AZ Edward B. Diethrich, MD Arizona Heart Foundation Phoenix, AZ Eric J. Dippel, MD Cardiovascular Medicine, PC Davenport, IA Simon R. Dixon, MBChB Beaumont Hospital Royal Oak, MI Ozgen Dogan, MD Columbia University Medical Center Pilar Dolcimascolo, RPA-C Columbia University Medical Center Feng Dong, MD, PhD Northeast Ohio Medical University Rootstown, OH Dennis J. Donohoe, MD Micell Durham, NC Shephal Doshi, MD Pacific Heart Institute Santa Monica, CA Pamela S. Douglas, MD, MAcc Duke Clinical Research Institute Durham, NC John S. Douglas Jr, MD Emory University School of Medicine Atlanta, GA Robert D. Dowling, MD University of Louisville School of Medicine Louisville, KY Douglas E. Drachman, MD Massachusetts General Hospital Boston, MA Danny Dvir, MD Washington Hospital Center Washington, DC Elazer R. Edelman, MD, PhD Brigham and Women s Hospital Cambridge, MA Neal L. Eigler, MD St. Jude Medical Sylmar, CA Andrew J. Einstein, MD, PhD Columbia University Medical Center Sally Elliott, BS, CCT, RCIS Sentara Chesapeake, VA Stephen G. Ellis, MD Cleveland Clinic Foundation Cleveland, OH Stephen E. Epstein, MD Washington Hospital Center Washington, DC Michael D. Ezekowitz, MB, ChB, DPhil Lankenau Medical Center Wynnewood, PA Andrew Farb, MD US Food and Drug Administration Silver Spring, MD Michael E. Farkouh, MD, MSc Mount Sinai School of Medicine David P. Faxon, MD Brigham and Women s Hospital Boston, MA William F. Fearon, MD Stanford University Medical Center Stanford, CA Frederick Feit, MD New York University Medical Center Marc D. Feldman, MD University of Texas Health Science Center at San Antonio San Antonio, TX Ted E. Feldman, MD Evanston Hospital Evanston, IL Valerian Fernandes, MD Medical University of South Carolina Charleston, SC Michael A. Fifer, MD Massachusetts General Hospital Boston, MA Tim A. Fischell, MD Heart Institute at Borgess Medical Center Kalamazoo, MI 42

45 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics Peter J. Fitzgerald, MD, PhD Stanford University Medical Center Stanford, CA Giuseppe Gioia, MD Drexel University Medical College Pomona, NJ Paul A. Gurbel, MD Sinai Hospital of Baltimore System Baltimore, MD Frank Hildner, MD Central Florida Heart Center Ocala, FL John M. Flack, MD, MPH Wayne State University Detroit, MI Lee Giorgi, MD St. Luke s Hospital Duluth, MN Hitinder S. Gurm, MD University of Michigan Medical Center Ann Arbor, MI Matthew G. Hillebrenner, MSE US Food and Drug Administration Silver Spring, MD Thomas J. Fogarty, MD Fogarty Institute for Innovation Mountain View, CA Sachin S. Goel, MD Cleveland Clinic Foundation Cleveland, OH Lee R. Guterman, MD, PhD Catholic Health System of Buffalo Amherst, NY John McB. Hodgson, MD Geisinger Health System Edwardsville, PA Gregory P. Fontana, MD Lenox Hill Hospital Heart and Vascular Institute Lenox Hill Hospital Theresa Franklin-Bond, MS, PA-C Mount Sinai School of Medicine William J. French, MD Harbor - UCLA Medical Center Torrance, CA Glenna Friedman, RN NewYork-Presbyterian Hospital/ Columbia University Medical Center Valentin Fuster, MD, PhD Mount Sinai Medical Center James S. Gammie, MD University of Maryland Heart Center Baltimore, MD Roger Gammon, MD Austin Heart Austin, TX Ripal T. Gandhi, MD Baptist Cardiac and Vascular Institute Miami, FL Lawrence A. Garcia, MD St. Elizabeth s Medical Center Boston, MA Philippe Genereux, MD Columbia University Medical Center Isaac George, MD NewYork-Presbyterian Hospital Robin E. Germany, MD University of Oklahoma College of Medicine Oklahoma City, OK Adam Geronemus, MD Baptist Cardiac and Vascular Institute South Miami, FL Bernard J. Gersh, MB, ChB, DPhil Mayo Clinic Rochester, MN Gary Gershony, MD John Muir Cardiovascular Institute Piedmont, CA C. Michael Gibson, MD Beth Israel Deaconess Medical Center Boston, MA Ian C. Gilchrist, MD Penn State/Hershey Medical Center Hershey, PA A. Marc Gillinov, MD Cleveland Clinic Foundation Cleveland, OH Sheldon Goldberg, MD Cardiology Consultants of Philadelphia Philadelphia, PA Steven L. Goldberg, MD University of Washington Seattle, WA Mark Goldberger, MD Columbia University Medical Center James A. Goldstein, MD Beaumont Health System Royal Oak, MI John Goncalves, MD Winthrop University Hospital Mineola, NY Kenneth A. Gorski, RN, RCIS, RCSA Cleveland Clinic Cleveland, OH Nilesh Goswami, MD Prairie Cardiovascular Springfield, IL Juan F. Granada, MD CRF Skirball Research Center Orangeburg, NY Christopher B. Granger, MD Duke University Medical Center Durham, NC J. Aaron Grantham, MD University of Missouri Kansas City and Mid America Heart Institute Kansas City, MO William A. Gray, MD NewYork-Presbyterian Hospital Paul A. Grayburn, MD Baylor University Medical Center Dallas, TX Philip Green, MD Columbia University Medical Center Cindy L. Grines, MD Detroit Medical Center Detroit, MI Kendra J. Grubb, MD, MHA NewYork-Presbyterian Hospital/ Columbia University Medical Center Luis Gruberg, MD Stony Brook University Medical Center Stony Brook, NY Alejandra Guerchicoff, PhD NYU Cardiovascular Genetics Program Michael Guiry, MBA, RPA-C NewYork-Presbyterian Hospital Robert A. Guyton, MD Emory University Hospital Atlanta, GA Luis A. Guzman, MD University of Florida Jacksonville, FL Rory Hachamovitch, MD, MSc Cleveland Clinic Cleveland, OH Rebecca Tung Hahn, MD NewYork-Presbyterian Hospital Jonathan L. Halperin, MD Mount Sinai Medical Institution Adam Hansgen, BS University of Colorado Health Sciences Center Aurora, CO Kishore J. Harjai, MD Guthrie Clinic Sayre, PA Robert A. Harrington, MD Stanford University Medical Center Stanford, CA Mahmoud Hashemian, MD, FACC Day Hospital, Tehran Tehran, CA Marian C. Hawkey, RN NewYork-Presbyterian Hospital/ Columbia University Medical Center William E. Hellenbrand, MD Yale New Haven Children s Hospital New Haven, CT Timothy D. Henry, MD Minneapolis Heart Institute Foundation Minneapolis, MN James B. Hermiller Jr, MD St. Vincent Hospital/The Heart Center of Indiana Indianapolis, IN Howard C. Herrmann, MD Hospital of the University of Pennsylvania Philadelphia, PA Richard R. Heuser, MD St. Luke s Medical Center Phoenix, AZ Jo Carol Hiatt, MD, MBA Kaiser Permanente Pasadena, CA Karen A. Hicks, MD US Food and Drug Administration Silver Spring, MD Ziyad M. Hijazi, MD, MPH Rush University Medical Center Chicago, IL David R. Holmes Jr, MD Mayo Clinic Rochester, MN Marsha Holton, CCRN, RCIS Cardiovascular Orientation Programs Indian Head, MD Shunichi Homma, MD NewYork-Presbyterian Hospital/ Columbia University Medical Center Yasuhiro Honda, MD Stanford University Medical Center Stanford, CA W. Craig Hooper, PhD Centers for Disease Control and Prevention Atlanta, GA L. Nelson Hopkins, MD Buffalo General Medical Center Buffalo, NY Robert A. Hopkins Bank of America Merrill Lynch Syed Hossainy, PhD Abbott Vascular Santa Clara, CA Frank F. Ing, MD Texas Children s Hospital Houston, TX Bob Jackson, BBA Keller, TX Elizabeth A. Jackson, MD, MPH University of Michigan Health System Ann Arbor, MI Alice K. Jacobs, MD Boston University Medical Center Boston, MA Jamey Jacobs, BS Abbott Vascular Menlo Park, CA Michael R. Jaff, DO Massachusetts General Hospital Boston, MA Allan S. Jaffe, MD Mayo Clinic Rochester, MN Farouc Jaffer, MD, PhD Massachusetts General Hospital Boston, MA Alexander J. Javois, MD Hope Children s Hospital Oak Lawn, IL Lisa K. Jennings, PhD University of Tennessee Health Science Center Memphis, TN 43

46 United States Faculty Tamara Syrek Jensen, JD Centers for Medicare and Medicaid Services Baltimore, MD Allen Jeremias, MD, MSc Stony Brook University Medical Center Stony Brook, NY Hasan Jilaihawi, BSc, MBChB Cedars-Sinai Heart Institute Los Angeles, CA Nils Johnson, MD, MS University of Texas Medical School Houston, TX Warren L. Johnson, MD Keystone Colorado Frisco, CO Thomas K. Jones, MD Seattle Children s Hospital Seattle, WA James D. Joye, DO El Camino Hospital Mountain View, CA William H. Julien, MD South Florida Vascular Associates Coconut Creek, FL Lowell Kabnick, MD New York University Medical School Joel Kahn, MD Detroit Medical Center West Bloomfield, MI Ankur Kalra, MD Minneapolis Heart Institute at Abbott Northwestern Hospital Minneapolis, MN Greg L. Kaluza, MD, PhD CRF Skirball Research Center Orangeburg, NY David E. Kandzari, MD Piedmont Heart Institute Atlanta, GA Samir R. Kapadia, MD Cleveland Clinic Foundation Cleveland, OH Aaron V. Kaplan, MD Dartmouth-Hitchcock Medical Center Lebanon, NH Navin K. Kapur, MD Tufts Medical Center Boston, MA Saibal Kar, MD Cedars-Sinai Medical Center Los Angeles, CA Dimitri Karmpaliotis, MD Piedmont Heart Institute Atlanta, GA Barry T. Katzen, MD Baptist Cardiac and Vascular Institute Miami, FL Sanjay Kaul, MD Cedars-Sinai Medical Center Los Angeles, CA Clifford J. Kavinsky, MD, PhD Rush University Medical Center Chicago, IL Polly Keller, RCIS Valencia College Ocoee, FL Dean J. Kereiakes, MD The Christ Hospital Cincinnati, OH Morton J. Kern, MD University of California Irvine Irvine, CA R. Stefan Kiesz, MD San Antonio Endovascular and Heart Institute San Antonio, TX Michael Kim, MD Mount Sinai Medical Center Michael S. Kim, MD University of Colorado Denver Aurora, CO Carey D. Kimmelstiel, MD Tufts Medical Center Boston, MA Spencer B. King III, MD Saint Joseph s Heart and Vascular Institute Atlanta, GA Nicholas N. Kipshidze, MD, PhD Lenox Hill Hospital Ajay J. Kirtane, MD, SM NewYork-Presbyterian Hospital/ Columbia University Medical Center Neal S. Kleiman, MD Methodist DeBakey Heart and Vascular Center Houston, TX Patricia E. Knipper, RN Columbia University Medical Center Susheel Kodali, MD NewYork-Presbyterian Hospital/ Columbia University Medical Center Raghu Kolluri, MD Prairie Vascular Institute Springfield, IL Maya Kommineni, MD Evanston Northwestern Healthcare Chicago, IL David F. Kong, MD, AM, DMT Duke University Medical Center Durham, NC Zvonimir Krajcer, MD St. Luke s Episcopal Hospital Houston, TX Paul H. Kramer, MD Liberty Cardiovascular Specialists Sunny Isles Beach, FL Prakash Krishnan, MD Mount Sinai Medical Center Mitchell W. Krucoff, MD Duke University Medical Center Durham, NC Spencer H. Kubo, MD Heart Leaflet Technologies Maple Grove, MN Aaron D. Kugelmass, MD Baystate Medical Center Springfield, MA Frederick Kushner, MD Heart Clinic of Louisiana Marrero, LA Robert Kutys, MS, PA(ASCP) CVPath Institute, Inc. Gaithersburg, MD Jeffrey T. Kuvin, MD Tufts Medical Center Boston, MA Elena Ladich, MD CVPath Institute, Inc. Gaithersburg, MD Roger J. Laham, MD Beth Israel Deaconess Medical Center Boston, MA John R. Laird Jr, MD UC Davis Medical Center Sacramento, CA Gervasio A. Lamas, MD Mount Sinai Medical Center Miami Beach, FL Alexandra J. Lansky, MD Yale School of Medicine New Haven, CT Tim J. Lapp, RCIS Lancaster General Hospital Lancaster, PA John M. Lasala, MD, PhD Washington University School of Medicine St. Louis, MO John Laschinger, MD US Food and Drug Administration Silver Spring, MD Randall T. Lashinski Claret Medical Santa Rosa, CA Harold L. Lazar, MD Boston Medical Center Boston, MA Robert J. Lederman, MD National Heart, Lung, and Blood Institute Bethesda, MD Michael S. Lee, MD UCLA Medical Center Los Angeles, CA Randall J. Lee, MD, PHD University of California, San Francisco San Francisco, CA W. Anthony Lee, MD Lynn Heart and Vascular Institute Boca Raton, FL Massoud A. Leesar, MD University of Alabama-Birmingham Birmingham, AL Nicholas J. Lembo, MD Piedmont Heart Institute Atlanta, GA Martin B. Leon, MD NewYork-Presbyterian Hospital/ Columbia University Medical Center Jane A. Leopold, MD Brigham and Women s Hospital Boston, MA Norman E. Lepor, MD Cedars-Sinai Medical Center Beverly Hills, CA Amir Lerman, MD Mayo Clinic Rochester, MN John C. Lewin, MD Lewin and Associates LLC Washington, DC Michael J. Lim, MD Saint Louis University Saint Louis, MO Scott Lim, MD UVA Medical Center Charlottesville, VA A. Michael Lincoff, MD Cleveland Clinic Foundation Cleveland, OH JoAnn Lindenfeld, MD University of Colorado Health Sciences Center Aurora, CO Italo Linfante, MD Baptist Cardiac and Vascular Institute Miami, FL William C. Little, MD Wake Forest University School of Medicine Winston-Salem, NC Frank Litvack, MD Cedars-Sinai Medical Center Los Angeles, CA Julie Logan, RN Foundation for Cardiovascular Medicine La Jolla, CA William L. Lombardi, MD PeaceHealth St. Joseph Medical Center Bellingham, WA Anthony Long, MBA Navigant Blanchard, OK Robert A. Lookstein, MD Mount Sinai Medical Center Monica Losquadro, MS, PAC St. Francis Hospital Roslyn, NY Reginald I. Low, MD UC Davis Heart Center Sacramento, CA Ulrich C. Luft, MD DEBORAH Heart and Lung Center Browns Mills, NJ Alan B. Lumsden, MD Methodist DeBakey Heart and Vascular Center Houston, TX Michael J. Mack, MD The Heart Hospital Baylor Plano Plano, TX Ryan D. Madder, MD Frederik Meijer Heart and Vascular Institute, Spectrum Health System Grand Rapids, MI 44

47 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics Akiko Maehara, MD Cardiovascular Research Foundation Brij Maini, MD Pinnacle Health System Harrisburg, PA Raj Makkar, MD Cedars-Sinai Medical Center Los Angeles, CA Thomas H. Maloney, MHA, RCIS Memorial Regional Medical Center Mechanicsville, VA Steven V. Manoukian, MD Sarah Cannon Research Institute Nashville, TN James R. Margolis, MD Jackson South Community Hospital Miami, FL David J. Maron, MD Vanderbilt Chest Pain Center Nashville, TN J. Jeffrey Marshall, MD Northeast Georgia Heart Center Gainesville, GA Steven P. Marso, MD St. Luke s Health System Kansas City, MO Tim R. Martin, RCIS Lancaster General Hospital Lancaster, PA Verghese Mathew, MD Mayo Clinic Rochester, MN Laura Mauri, MD, MSc Brigham and Women s Hospital Boston, MA Meital Mazor, MD Vessix Vascular Laguna Hills, CA Patrick M. McCarthy, MD Northwestern University Chicago, IL Daniel J. McCormick, DO Hahnemann University Hospital Philadelphia, PA Doff B. McElhinney, MD NYU Medical Center Casey McGlynn, JD Wilson Sonsini Goodrich and Rosati Palo Alto, CA James F. McKinsey, MD NewYork-Presbyterian Hospital/ Columbia University Medical Center Dennis M. McNamara, MD University of Pittsburgh Medical Center Pittsburgh, PA Thomas O. McNamara, MD UCLA Medical Center Carson City, NV John A. McPherson, MD Vanderbilt University Nashville, TN Jessica L. Mega, MD Brigham and Women s Hospital Boston, MA David M. Mego, MD Arkansas Heart Hospital Little Rock, AR Roxana Mehran, MD Mount Sinai School of Medicine Sameer Mehta, MD Columbia Cedars Medical Center Miami, FL Carlos I. Mena, MD Yale-New Haven Hospital New Haven, CT John C. Messenger, MD University of Colorado School of Medicine Aurora, CO D. Christopher Metzger, MD Wellmont CVA Heart Institute Kingsport, TN Philip M. Meyers, MD NewYork-Presbyterian Hospital/ Columbia University Medical Center Robert E. Michler, MD Montefiore Medical Center Stephanie Lynn Mick, MD Cleveland Clinic Health System Cleveland, OH Issam Mikati, MD Northwestern Memorial Hospital Chicago, IL D. Craig Miller, MD Stanford University Medical School Stanford, CA Leslie W. Miller, MD University of South Florida Tampa, FL Paul J. Miller, MS Boston Scientific Maple Grove, MN James K. Min, MD Cedars-Sinai Medical Center Los Angeles, CA Gary S. Mintz, MD Cardiovascular Research Foundation Washington, DC Greg Mishkel, MD Prairie Cardiovascular Consultants Springfield, IL David J. Moliterno, MD University of Kentucky Lexington, KY Michael Mooney, MD Minneapolis Heart Institute Foundation Minneapolis, MN Pedro R. Moreno, MD Mount Sinai Medical Center David A. Morrow, MD, MPH Brigham and Women s Hospital Boston, MA Jeffrey W. Moses, MD NewYork-Presbyterian Hospital/ Columbia University Medical Center Issam D. Moussa, MD Mayo Clinic, Jacksonville Jacksonville, FL James E. Muller, MD InfraReDx Burlington, MA Sherif F. Nagueh, MD Methodist DeBakey Heart and Vascular Center, The Methodist Hospital Houston, TX Srihari S. Naidu, MD Winthrop University Hospital Mineola, NY Masataka Nakano, MD CVPath Institute, Inc Gaithersburg, MD Brahmajee K. Nallamothu, MD, MPH University of Michigan Medical School Ann Arbor, MI Jagat Narula, MD, PhD Mount Sinai School of Medicine Tamim Nazif, MD Columbia University Medical Center Christopher M. Nelson, RN, RCIS Sentara College of Health Sciences Chesapeake, VA Graham Nichol, MD, MPH Harborview Medical Center Seattle, WA Christopher D. Nielsen, MD Medical University of South Carolina Charleston, SC Hilary Nierenberg, NP, MPH Columbia University Medical Center Vuyisile T. Nkomo, MD Mayo Clinic Rochester, MN John O Connell, MD Heart Failure Consultants Sunset, SC Michelle O Donoghue, MD, MPH Brigham and Women s Hospital Boston, MA Patrick T. O Gara, MD Brigham and Women s Hospital Boston, MA E. Magnus Ohman, MD Duke University Medical Center Durham, NC Semih Oktay, PhD CardioMed Device Consultants Baltimore, MD Jeffrey W. Olin, DO Mount Sinai School of Medicine William W. O Neill, MD University of Miami Miami, FL Christopher D. Owens, MD University of California, San Francisco Medical Center San Francisco, CA Igor F. Palacios, MD Massachusetts General Hospital Boston, MA James M. Palazzo, MBA Navigant Southlake, TX Julio C. Palmaz, MD University of Texas Health Science Center at San Antonio San Antonio, TX Samir B. Pancholy, MD Wright Center for Graduate Medical Education and the Commonwealth Medical College Clarks Summit, PA Vasilios Papademetriou, MD VA Medical Center Washington, DC Jean-Michel Paradis, MD Columbia University Medical Center Duk-Woo Park, MD Duke Clinical Researc Center Durham, NC Manish A. Parikh, MD Columbia University Medical Center Sahil A. Parikh, MD University Hospitals Case Medical Center Cleveland, OH Helen Parise, ScD Cardiovascular Research Foundation Juan C. Parodi, MD University of Miami Pinecrest, FL Amit Patel, MD, MS University of Utah Salt Lake City, UT Manesh R. Patel, MD Duke University Medical Center Durham, NC Sonna M. Patel-Raman, PhD US Food and Drug Administration Silver Spring, MD Raghotham R. Patlola, MD Cardiovascular Institute of the South Lafayette, LA Bray Patrick-Lake PFO Research Foundation Boulder, CO Wesley R. Pedersen, MD Minneapolis Heart Institute Foundation Minneapolis, MN Constantino S. Pena, MD Baptist Cardiac and Vascular Institute Miami, FL Lynn F. Peng, MD Stanford University Medical Center Stanford, CA Marc S. Penn, MD, PhD Summa Health System Akron, OH 45

48 United States Faculty Emerson C. Perin, MD, PhD Texas Heart Institute Houston, TX Richard J. Rapoza, PhD Abbott Vascular Santa Clara, CA Eric E. Roselli, MD Cleveland Clinic Foundation Cleveland, OH Gary L. Schaer, MD Rush University Medical Center Chicago, IL Ashish Pershad, MD Heart and Vascular Center of Arizona Phoenix, AZ Mahmood K. Razavi, MD St. Joseph Cardiac and Vascular Center Orange, CA Marlon Rosenbaum, MD Columbia Universtiy Medical Center Robert M. Schainfeld, DO Massachusetts General Hospital Boston, MA Harry R. Phillips, MD Duke University Medical Center Durham, NC Michael J. Reardon, MD The Methodist Hospital Houston, TX Gregg Rosner, MD Columbia University Medical Center Richard A. Schatz, MD Scripps Clinic La Jolla, CA Augusto D. Pichard, MD Washington Hospital Center Washington, DC Vivek Y. Reddy, MD Mount Sinai Medical Center Martin T. Rothman, MD, MB, ChB Medtronic CardioVascular Santa Rosa, CA Peter A. Schneider, MD Kaiser Permanente Honolulu, HI Ileana L. Pina, MD, MPH Montefiore Medical Center Bronx, NY Glenn Reicin Skyline Ventures Palo Alto, CA Joshua Rovin, MD Morton Plant Hospital Clearwater, FL Susan J. Schnell, ACNP-BC Meridian Health Systems Neptune, NJ Duane S. Pinto, MD, MPH Beth Israel Deaconess Medical Center Boston, MA Mark Reisman, MD Swedish Heart and Vascular Institute Seattle, WA Stanton J. Rowe Edwards Lifesciences Irvine, CA Theodore L. Schreiber, MD Cardiovascular Consultants Warren, MI Roel R. Pinzon, BSN, RN NewYork-Presbyterian Hospital Matthew R. Reynolds, MD, MSc Beth Israel Deaconess Medical Center Boston, MA Stephen Rowland, PhD OrbusNeich Fort Lauderdale, FL Allan Schwartz, MD Columbia University Medical Center Donna Polk, MD, MPH Hartford Hospital Hartford, CT Jeffrey J. Popma, MD Beth Israel Deaconess Medical Center Newton, MA Thomas J. Povsic, MD, PhD Duke University Medical Center Chapel Hill, NC Alex Powell, MD Baptist Cardiac and Vascular Institute Miami, FL Matthew J. Price, MD Scripps Clinic La Jolla, CA Lauren T. Privitera, MPH Columbia University Medical Center, Health Policy and Management Andrew W. Proctor, MS Cleveland Clinic Lyndhurst, OH John D. Puskas, MD, MSc Emory University Hospital Midtown Atlanta, GA Christopher Pyne, MD Lahey Clinic Burlington, MA Robert T. Pyo, MD Mount Sinai Medical Center Ramon Quesada, MD Baptist Cardiac and Vascular Institute of Miami Miami, FL C. Venkata S. Ram, MD Dallas Nephrology Associates Dallas, TX Stephen R. Ramee, MD Ochsner Medical Center New Orleans, LA Sunil V. Rao, MD Duke University Medical Center Durham, NC John F. Rhodes, MD Duke University Medical Center Durham, NC Joseph J. Ricotta II, MD, MS, FACS Northside Hospital Health System Atlanta, GA Charanjit S. Rihal, MD Mayo Clinic Rochester, MN Michael J. Rinaldi, MD Sanger Heart and Vascular Institute/ Carolinas Medical Center Charlotte, NC Marian K. Rippy, DVM, PhD Rippy Pathology Solutions Woodbury, MN David G. Rizik, MD Scottsdale Heart Group Scottsdale, AZ Rhonda Robb Medtronic Minneapolis, MN Jonathan S. Roberts, MD Baptist Cardiac and Vascular Institute, Baptist Hospital of Miami Miami, FL Krishna J. Rocha-Singh, MD Prairie Heart Institute, St. John s Hospital Springfield, IL Matthew T. Roe, MD, MHS Duke Clinical Research Institute Durham, NC Jason H. Rogers, MD UC Davis Medical Center Sacramento, CA Joseph G. Rogers, MD Duke University School of Medicine Durham, NC Ivan C. Rokos, MD Olive View Medical Center Sylmar, CA Eric A. Rose, MD NewYork-Presbyterian Hospital Carlos E. Ruiz, MD, PhD Lenox Hill Hospital and North Shore Long Island Jewish Health System John H. Rundback, MD Holy Name Hospital Teaneck, NJ Barry D. Rutherford, MD Cardiovascular Consultants, PC Kansas City, MO Joseph F. Sabik, MD Cleveland Clinic Foundation Cleveland, OH Robert D. Safian, MD Beaumont Health System Royal Oak, MI Kenichi Sakakura, MD Gaithersburg, MD Sean Salmon, MBA Coronary and Renal Denervation Santa Rosa, CA Habib Samady, MD Emory University Hospital Atlanta, GA Gregory Sampognaro, MD P & S Surgical Hospital Monroe, LA Shaun L. Samuels, MD Baptist Cardiac and Vascular Institute Miami, FL Maurice E. Sarano, MD Mayo Clinic Rochester, MN Ashwani Sastry, MD US Food and Drug Administration Silver Spring, MD Lowell F. Satler, MD Washington Cardiology Center Washington, DC Jeffrey L. Saver, MD UCLA Stroke Center Los Angeles, CA Sonia Scalf, RN, BSN Vanderbilt Heart and Vascular Institute Nashville, TN Richard Keith Schwartz, MD Winthrop University Hospital Garden City, NY Robert S. Schwartz, MD Minneapolis Heart Institute Foundation Minneapolis, MN Kimberly Selzman, MD, MPH University of Utah Health Sciences Center Salt Lake City, UT Samin K. Sharma, MD Mount Sinai Medical Center Fayaz Shawl, MD Washington Adventist Hospital Takoma Park, MD James R. Shay, JD, BSE Shay Glenn LLP San Mateo, CA Warren Sherman, MD NewYork-Presbyterian Hosptial Thomas M. Shimshak, MD Wheaton Franciscan Healthcare Racine, WI Mehdi H. Shishehbor, DO, MPH Cleveland Clinic Foundation Cleveland, OH Adhir Shroff, MD, MPH University of Illinois Hospital and Health Sciences System Chicago, IL Robert J. Siegel, MD Cedars-Sinai Medical Center Los Angeles, CA Frank E. Silvestry, MD Hospital of the University of Pennsylvania Philadelphia, PA Robert D. Simari, MD Mayo Clinic Rochester, MN Daniel I. Simon, MD University Hospitals Case Medical Center Cleveland, OH 46

49 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics Pamela P. Simons St. Jude Medical, Inc. Plymouth, MN Niel F. Starksen, MD Guided Delivery Systems Inc. Santa Clara, CA Henry H. Ting, MD, MBA Mayo Clinic Rochester, MN Bonnie H. Weiner, MD, MSEC, MBA Worcester Medical Center Worcester, MA Charles A. Simonton, MD Abbott Vascular Santa Clara, CA John B. Simpson, MD, PhD Sequoia Hospital Redwood City, CA Varinder P. Singh, MD NewYork-Presbyterian Hospital/ Columbia University Medical Center Kimberly A. Skelding, MD Geisinger Medical Center Danville, PA Kristen Skelton Edwards Lifesciences Corporation Irvine, CA Marvin J. Slepian, MD The University of Arizona Health Sciences Center Tucson, AZ Richard Smalling, MD, PhD Memorial Hermann Heart and Vascular Institute Houston, TX A.J. Conrad Smith, MD Heart and Vascular Institute, UPMC Presbyterian Pittsburgh, PA Craig R. Smith, MD NewYork-Presbyterian Hospital/ Columbia University Medical Center Paul A. Sobotka, MD Hennepin County Medical Center West St Paul, MN Daniel Soffer, MD Mount Sinai Medical Center Richard Solomon, MD University of Vermont Burlington, VT Robert J. Sommer, MD NewYork-Presbyterian Hospital Paul Sorajja, MD Mayo Clinic Rochester, MN John A. Spertus, MD Mid America Heart Institute Kansas City, MO Douglas Spriggs, MD Morton Plant Hospital Clearwater, FL Mukta Srivastava, MD University of Maryland Medical Center Baltimore, MD Frederick G. St. Goar, MD Advanced Cardiovascular Specialists Mountain View, CA Richard S. Stack, MD Duke University Chapel Hill, NC William N. Starling, MBA Synecor, LLC Portola Valley, CA Evan A. Stein, MD Metabolic and Atherosclerosis Research Center Cinncinati, OH Allan Stewart, MD Columbia University Medical Center Gregg W. Stone, MD NewYork-Presbyterian Hospital/ Columbia University Medical Center Peter H. Stone, MD Brigham and Women s Hospital Boston, MA Dave Strelow Saint Luke s Mid America Heart Institute Kansas City, MO Thomas D. Stuckey, MD Moses Cone Heart and Vascular Center Lebauer Cardiovascular Research Foundation Greensboro, NC Mitchell Sugarman, MBA Medtronic Santa Rosa, CA H. Robert Superko, MD Saint Joseph s Translational Research Institute Alameda, CA Lars G. Svensson, MD, PhD Cleveland Clinic Foundation Cleveland, OH Brian Sweeney, RN, MBA Thomas Jefferson University Hospitals Philadelphia, PA Molly Szerlip, MD The Univerity of Arizona Sarver Heart Center Tucson, AZ Wilson Y. Szeto, MD University of Pennsylvania Medical Center Philadelphia, PA Jacqueline E. Tamis-Holland, MD St. Luke s-roosevelt Hospital Guillermo Tearney, MD, PhD Massachusetts General Hospital Boston, MA Paul S. Teirstein, MD Scripps Clinic and Research Foundation La Jolla, CA David E. Thaler, MD, PhD Tufts Medical Center Boston, MA Craig A. Thompson, MD, MMSc Yale New Haven Hospital New Haven, CT Vinod H. Thourani, MD Emory University Hospital Midtown Atlanta, GA Jonathan M. Tobis, MD UCLA Medical Center Los Angeles, CA Thomas M. Todoran, MD Medical University of South Carolina Charleston, SC Sadaf Toor, MS US Food and Drug Administration Silver Spring, MD On Topaz, MD Charles George Veterans Affairs Medical Center Asheville, NC Sara Toyloy ElixirMedical Birmingham, AL Jennifer A. Tremmel, MD Stanford University Medical Center Stanford, CA Alfredo Trento, MD Cedars-Sinai Medical Center Los Angeles, CA Thomas M. Tu, MD Louisville Cardiology Medical Group Louisville, KY Mark A. Turco, MD Covidien Washington, DC Zoltan G. Turi, MD Cooper University Hospital Camden, NJ E. Murat Tuzcu, MD Cleveland Clinic Foundation Cleveland, OH Mahesh M. Uberoi MphRx Princeton, NJ Santosh Venkatesha, MBA Vigilant Medical Baltimore, MD Ralph J. Verdino, MD University of Pennsylvania Philadelphia, PA George W. Vetrovec, MD VCU Medical Center Richmond, VA Renu Virmani, MD CVPath Institute, Inc. Gaithersburg, MD Szilard Voros, MD Integrated Cardiovascular Research Group East Setauket, NY Ron Waksman, MD Medstar Heart Institute Washington, DC Craig M. Walker, MD Cardiovascular Institute of the South Houma, LA Howard T. Walpole, MD, MBA, CPE Okyanos Heart Institute Belleair Bluffs, FL Michael Weinstein Dallas, TX William S. Weintraub, MD Christiana Care Health Services Newark, DE Neil J. Weissman, MD MedStar Washington Hospital Center Washington, DC Giora Weisz, MD NewYork-Presbyterian Hospital/ Columbia University Medical Center Grayson H. Wheatley, MD Arizona Heart Institute Phoenix, AZ Brian K. Whisenant, MD Intermountain Medical Center Salt Lake City, UT Christopher J. White, MD Ochsner Heart and Vascular Institute New Orleans, LA Patrick L. Whitlow, MD Cleveland Clinic Foundation Cleveland, OH Mark H. Wholey, MD Allegheny General Hospital Pittsburgh, PA Michael H. Wholey, MD Christus Santa Rosa Medical Center San Antonio, TX Josiah N. Wilcox, PhD Medtronic CardioVascular Santa Rosa, CA Robert L. Wilensky, MD Hospital of the University of Pennsylvania Philadelphia, PA Jose M. Wiley, MD Mount Sinai Medical Center David O. Williams, MD Brigham and Women s Hospital Boston, MA Mathew Williams, MD NewYork-Presbyterian Hospital/ Columbia University Medical Center Steve Winitsky, MD US Food and Drug Administration Rockville, MD Stephen D. Wiviott, MD Brigham and Women s Hospital Boston, MA S. Chiu Wong, MD NewYork-Presbyterian Hospital/ Weill Cornell Medical College Larry L. Wood Edwards Lifesciences Irvine, CA Janet F. Wyman, DNP ACCF Cardiac Catheterization and Intervention Committee Grosse Pointe Park, MI 47

50 United States Faculty R. Michael Wyman, MD Torrance Memorial Medical Center Torrance, CA Jay S. Yadav, MD Piedmont Hospital Atlanta, GA Steven J. Yakubov, MD Riverside Methodist Hospital Columbus, OH Robert W. Yeh, MD, MBA Massachusetts General Hospital Boston, MA Alan C. Yeung, MD Stanford University Medical Center Stanford, CA Paul G. Yock, MD Stanford University Biodesign Program Stanford, CA Sibin Zacharias, MD Beaumont Health System Royal Oak, MI Christopher K. Zarins, MD Stanford University Medical Center Stanford, CA James P. Zidar, MD Rex Healthcare Raleigh, NC John R. Zimmerman, MSN, RN Memorial Regional Medical Center Chester, VA David Zimrin, MD University of Maryland Medical Center Baltimore, MD 48

51 Live Case Sites and Operators/FActoid Faculty High-definition live case transmission sites span 20 locations around the globe. Live cases offer unique, invaluable learning opportunities at TCT. International Cardiovascular Center Aalst Aalst, Belgium Emanuele Barbato, MD, PhD Jozef Bartunek, MD, PhD Bernard De Bruyne, MD, PhD Tom De Potter, MD Marc Vanderheyden, MD William Wijns, MD, PhD Eric Wyffels, MD Cardiovascular Centre, ZNA Middelheim Hospital Antwerp, Belgium Carl Convens, MD Glenn Van Langenhove, MD, PhD Stefan Verheye, MD, PhD Paul Vermeersch, MD, PhD CARE Hospitals Hyderabad, India Nageshwar Rao Koneti, MD, DM Sreenivas Kumar, MD, DM B. Soma Raju, MD, DM P. Raghava Raju MD, DM Ferrarotto Hospital Catania, Italy M. Di Salvo, MD S. Imme, MD A. La Manna, MD C. Sgroi, MD Corrado Tamburino, MD, PhD Fundación Favaloro Buenos Aires, Argentina Gaspar Caponi, MD Carlos A. Fava, MD Gustavo A. Lev, MD Oscar A. Mendiz, MD León R. Valdivieso, MD Hôpital Charles Nicolle Rouen, France Alain G. Cribier, MD Helene Eltchaninoff, MD Matthieu Godin, MD Instituto Dante Pazzanese de Cardiologia São Paulo, Brazil Alexandre Abizaid, MD, PhD Magaly Arraes, MD Daniel Chamie, MD Jose de Ribamar Costa Jr, MD Ricardo Costa, MD, PhD Fausto Feres, MD, PhD Carlos Pedra, MD, PhD Eduardo Sousa, MD, PhD Rodolfo Staico, MD, PhD Park-Krankenhaus Leipzig Leipzig, Germany Sven Bräunlich, MD Dierk Scheinert, MD Andrej Schmidt, MD Matthias Ulrich, MD Royal Sussex County Hospital Brighton, United Kingdom Adam J. de Belder, MD Lucy Blows, MD David J. Hildick-Smith, MD Stephen Holmberg, MD Keith G. Oldroyd, MD Simon Redwood, MD Shaare Zedek Medical Center Jerusalem, Israel Yaron Almagor, MD Jonathan Balkin, MD Adi Butnaru, MD Marc Klutstein, MD David Meerkin, MD David Rosenmann, MD St. Paul s Hospital/ University of British Columbia Vancouver, Canada Anson Cheung, MD John G. Webb, MD David A. Wood, MD University Hospital Bonn Bonn, Germany Eberhard Grube, MD Andreas Hoeft, MD Georg Nickenig, MD Armin Welz, MD Nikos Werner, MD United States Baptist Cardiac and Vascular Institute Miami, FL James F. Benenati, MD Ripal T. Gandhi, MD Barry T. Katzen, MD Constantino S. Pena, MD Alex Powell, MD Ramon Quesada, MD Shaun L. Samuels, MD Mount Sinai Medical Center Miami, FL Nirat Beohar, MD Michael B. Collins, MD Martin B. Leon, MD Akiko Maehara, MD Giora Wiesz, MD Nationwide Children s Hospital Columbus, OH John P. Cheatham, MD Sharon L. Cheatham, ACNP, PhD Ralf J. Holzer, MD NewYork-Presbyterian Hospital/Columbia University Medical Center William A. Gray, MD Susheel Kodali, MD Robert J. Sommer, MD Giora Weisz, MD Mathew Williams, MD Piedmont Heart Institute Atlanta, GA Harold Carlson, MD Anna Kalynych, MD David E. Kandzari, MD Dimitri Karmpaliotis, MD Nicholas J. Lembo, MD Rush University Medical Center Chicago, IL Qi-Ling Cao, MD Ziyad M. Hijazi, MD, MPH Cliff Kavinsky, MD, PhD Damien Kenny, MD Scripps Green Hospital La Jolla, CA Matthew J. Price, MD Curtiss Stinis, MD Paul S. Teirstein, MD Craig A. Thompson, MD, MMSc Swedish Health Services Seattle, WA Robert Bersin, MD Amish Desai, MD Paul Huang, MD John Petersen II, MD Mark Reisman, MD Factoid Faculty Elissa Altin, MD Adriano Caixeta, MD, PhD Daniel Silva Chamié de Queiroz, MD Vasiliki Chantziara, MD Bimmer E. Claessen, MD, PhD Jose de Ribamar Costa Jr, MD Hemal Gada, MD Philip Green, MD Nilusha Gukathasan, MD Shinji Inaba, MD Nisharahmed Kherada, MD Thosaphol Limpanjit, MD Margaret B. McEntegart, MD Elias Sanidas, MD Takehisa Shimizu, MD, PhD Madhusudhan Tarigopula, MD Kleanthis Theodoropoulos, MD Torsten P. Vahl, MD 49

52 Sunday, October 21 ABCs of Interventional Cardiology: An Introductory Course 1:00 pm-6:00 pm Junior Ballroom C This session is not CME/CNE accredited. Session I. Basics of Cardiac Anatomy and Angiography Moderators: George D. Dangas, Frederick Feit 1:00 pm - Cardiac and Coronary Anatomy 1:12 pm - Discussion with Q&A 1:15 pm - Right Heart Catheterization: Technique and Hemodynamics Robert T. Pyo 1:27 pm - Discussion with Q&A 1:30 pm - Left Heart Catheterization: Technique and Hemodynamics Duane S. Pinto 1:42 pm - Discussion with Q&A 1:45 pm - Coronary Angiography 1: Basic Technique and Interpretation Frederick Feit 1:57 pm - Discussion with Q&A 2:00 pm - Coronary Angiography 2: Artifacts and Pitfalls Ajay J. Kirtane 2:12 pm - Discussion with Q&A 2:15 pm - Intravascular Imaging: Core Concepts Ziad Ali 2:27 pm - Discussion with Q&A 2:30 pm - Break Session II. Basics of Cardiovascular Pathophysiology Moderators: Juan F. Granada, Duane S. Pinto 2:45 pm - Coronary Artery Disease: Pathology and Pathogenesis Juan F. Granada 2:57 pm - Discussion with Q&A 3:00 pm - Coronary Pathophysiology and Fractional Flow Reserve (FFR) Jason Kovacic 3:12 pm - Discussion with Q&A 3:15 pm - Acute Coronary Syndromes: NSTEMI Duane S. Pinto 3:27 pm - Discussion with Q&A 3:30 pm - Acute Coronary Syndromes: STEMI Michael S. Kim 3:42 pm - Discussion with Q&A 3:45 pm - Valvular Heart Disease for the Interventionalist Susheel Kodali 3:57 pm - Discussion with Q&A 4:00 pm - Congestive Heart Failure and Cardiomyopathy Sean P. Pinney 4:12 pm - Discussion with Q&A 4:15 pm - Break Session III. Introduction to Coronary Angioplasty and Stenting Moderators: Ajay J. Kirtane, Manish A. Parikh 4:30 pm - Cath Lab Room Setup Duane S. Pinto 4:42 pm - Discussion with Q&A 4:45 pm - Vascular Access Routes and Technique Robert T. Pyo 4:57 pm - Discussion with Q&A 5:00 pm - Guiding Catheters and Wires Manish A. Parikh 5:12 pm - Discussion with Q&A 5:15 pm - Balloon Angioplasty: Equipment and Results Manish A. Parikh 5:27 pm - Discussion with Q&A 5:30 pm - Metallic Stent Technology: Design Considerations Juan F. Granada 5:42 pm - Discussion with Q&A 5:45 pm - Drug-Eluting Stent Systems and Outcomes: Good and Bad Ajay J. Kirtane 5:57 pm - Discussion with Q&A 6:00 pm - Adjourn 50

53 Board Review Course with Self-Assessment for Interventional Cardiology with Concepts of Endovascular Therapy (Part 1)...52 TCT for Nurses and Technologists...52 TCT: An Integrated Course for Surgeons and Interventionalists...64 Scientific Symposia Chronic Total Occlusions: Evolutionary Approaches...53 Core Training Curriculum in Clinical Research...54 Endovascular Intervention 2012 (Part 1)...56 Interventional Innovation: Novel Therapies and the Best New Device Concepts for Left Main and Bifurcation Stenting: An Advanced Operator s Workshop...60 Strategies for Cardiovascular Repair: Stem Cells and Beyond...61 The Drug-Eluting Stent Summit: Appropriate Utilization of Current Generation Devices...62 The Valvular Heart Disease Summit (Part 1): Aortic Valve Therapies...64 PFO and ASD Closure: Evolving Indications, Patient Selection, Devices, and Techniques...66 Special Twilight Sessions Featured Clinical Research I...67 Featured Clinical Research II...67 Focus on India: Interactive Case Review and Panel Discussion...67 Approach to Complex PCI and STEMI: From Revascularization to Complication Management...68 How to Treat Complex Coronary Lesions...68 Monday October 22, 2012 Miami Beach Convention Center miami, FL Left Main and Bifurcation Stenting: Integrated Use of FFR and IVUS...68 Snapshot of Latin America Practice and Research...69 TCT Russia...69 The Elderly Patient: Better Treatment in the United States or Europe?...69 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics

54 Monday, October 22 Board Review Course with Self-Assessment for Interventional Cardiology with Concepts of Endovascular Therapy (Part 1) 8:00 am-6:00 pm Junior Ballroom C This session is only CME accredited. 8:00 am - Welcome and Introduction George D. Dangas Central Concepts of PCI Moderators: Tayo A. Addo, George D. Dangas Discussants: Robert J. Applegate, Usman Baber, Stephen Balter, Varinder P. Singh 8:05 am - Medical Statistics and Trial Design: Lessons from Recent Publications Usman Baber 8:25 am - Discussion with Q&A 8:30 am - Radiation Principles and Safety Stephen Balter 8:50 am - Discussion with Q&A 9:00 am - Femoral Vascular Access: Technique, Closure Devices, and Complications Robert J. Applegate 9:15 am - Discussion with Q&A 9:20 am - Radial Artery Access and Closure: Technique, Results, and Complications Varinder P. Singh 9:35 am - Discussion with Q&A 9:40 am - Break PCI Strategies, Indications, Guidelines, and Outcomes Moderators: Emmanouil S. Brilakis, George D. Dangas Discussants: Tayo A. Addo, Manish A. Parikh, Duane S. Pinto 10:00 am - PCI in Stable Coronary Artery Disease: Risk Stratification and Comparison with Medical and Surgical Alternatives Manish A. Parikh 10:20 am - Discussion with Q&A 10:30 am - PCI in Acute Coronary Syndromes and NSTEMI: Guidelines, Strategies, and Outcomes George D. Dangas 10:50 am - Discussion with Q&A 11:00 am - Primary PCI for STEMI: Guidelines, Strategies, and Outcomes Tayo A. Addo 11:20 am - Discussion with Q&A 11:30 am - Pharmacoinvasive Strategies (Facilitated, Rescue, and Transfer PCI) in STEMI Duane S. Pinto 11:50 am - Discussion with Q&A 12:00 pm - Cardiogenic Shock and Hemodynamic Support Alternatives Duane S. Pinto 12:20 pm - Discussion with Q&A 12:30 - Lunch Break Interventional Pharmacology: Guidelines and Practice Outcomes Moderators: Tayo A. Addo, George D. Dangas Discussants: Emmanouil S. Brilakis, Matthew J. Price, Gregg W. Stone 1:30 pm - Pharmacotherapy for Elective (Nonurgent) PCI Matthew J. Price 1:50 pm - Discussion with Q&A 2:00 pm - Pharmacotherapy for Acute Coronary Syndromes/NSTEMI Emmanouil S. Brilakis 2:20 pm - Discussion with Q&A 2:30 pm - Pharmacotherapy for PCI in STEMI Gregg W. Stone 2:50 pm - Discussion with Q&A 3:00 pm - Platelet Reactivity, Genetics, and Thienopyridine Responsiveness: Theoretical and Real-world Implications Matthew J. Price 3:20 pm - Discussion with Q&A 3:30 pm - Break Valvular and Structural Heart Disease Moderators: Susheel Kodali, Zoltan G. Turi Discussant: Robert J. Sommer 4:00 pm - Aortic Valve Disease Hemodynamics and Intervention with Approved Devices (Including Related Guidelines) Susheel Kodali 4:20 pm - Discussion with Q&A 4:30 pm - Mitral Valve Disease Hemodynamics, Balloon Valvuloplasty and the Edge-to-Edge Approach (Including Related Guidelines) Zoltan G. Turi 4:50 pm - Discussion with Q&A 5:00 pm - Essentials of Adult Congenital Heart Disease Intervention: Diagnosis, Devices, and Outcomes Robert J. Sommer 5:20 pm - Discussion with Q&A 5:30 pm - Specialized Structural Interventions: Approaches to HOCM, Paravalvular Leak, Acute MI VSD, and LAA Closure Robert J. Sommer 5:50 pm - Discussion with Q&A 6:00 pm - Adjourn TCT for Nurses and Technologists 8:00 am-5:30 pm Room B This session is only CNE accredited. 21st Annual Cardiovascular Nurse and Technologist Symposium 8:00 am - Introduction and Review of Learning Objectives Marian C. Hawkey 8:10 am - Technical Aspects of TAVR: Past, Present, and Future Alain G. Cribier Presentations and Panel Discussion with Integrated Audience Response Applying the Appropriate Use Criteria (AUC) to the patient with Multivessel Coronary Artery Disease Moderator: Thomas H. Maloney Discussants: William F. Fearon, Michael Guiry, David J. Maron, Sonia Scalf 8:40 am - The Appropriate Use Criteria: Genesis, Application, and Next Steps Thomas H. Maloney 8:50 am - Case Introduction Thomas H. Maloney 8:55 am - Assessment: Clinical Cardiologist David J. Maron 9:03 am - Assessment: Interventional Cardiologist William F. Fearon 9:16 am - Assessment: Hospital Administrator Michael Guiry 9:11 am - Case Continuation Thomas H. Maloney 9:20 am - Discussion with Q&A 52

55 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics Utilization of Preprocedure Risk Assessments to Prevent Postprocedure Complications Moderator: Janet F. Wyman Discussants: Ralph G. Brindis, Siro Buendia, Sarah Clarke, Roxana Mehran 9:30 am - Contrast-Induced Nephrotoxicity Roxana Mehran 9:42 am - Vascular Damage Sarah Clarke 9:54 am - In-Hospital Mortality and Major Complications (NCDR CathPCI) Ralph G. Brindis 10:10 am - Discussion with Q&A 12:15 pm - Introduction and Session Objectives Thomas H. Maloney 12:20 pm - Coronary Angiography from the Interventional Cardiologist s Perspective George W. Vetrovec 12:40 pm - Basics of the Heart and Related Structures from the Pathologist s Perspective Elena Ladich 1:00 pm - Hemodynamics of the Normal Heart from the Technologist s Perspective Sally Elliott 1:20 pm - Discussion with Q&A 3:50 pm - Taped Case from Seattle Science Foundation at Transcatheter Valve Therapies 2012 (Courtesy of Mark Reisman) Session V. Hands on Heart Bioskills Session 4:30 pm - Hands on Hearts (Cadaver Hearts Courtesy of CVPath Institute and Renu Virmani) 5:30 pm - Adjourn Scientific Symposia monday - October 22, 2012 Transcatheter Aortic Valve Replacement (TAVR) 2012 Moderator: Marian C. Hawkey Discussants: Marjo de Ronde, Susheel Kodali, Sandra Lauck, Roel R. Pinzon, Susan J. Schnell 10:20 am - Current Landscape: One-Year Post-Initial FDA Approval Susheel Kodali 10:32 am - Patient Selection: The Balance Between Utility and Futility Sandra Lauck 10:44 am - Preventing and Managing Complications Susan J. Schnell 10:56 am - Real-world Integration of OR and Cath Lab Staff for TAVR Procedures Roel R. Pinzon 11:03 am - Discussion with Q&A Future Technologies Moderator: Russell A. Brandwein Discussants: Hector M. Garcia-Garcia, Lynne Hinterbuchner 11:10 am - LAA Closure Devices Russell A. Brandwein 11:25 am - Renal Sympathetic Denervation for HTN Lynne Hinterbuchner 11:40 am - Bioresorbable Stents Hector M. Garcia-Garcia 11:55 am - Discussion with Q&A 12:00 pm - Adjourn with Lunch Pick-up Registered Cardiovascular Invasive Specialists (RCIS) Review Course Session I. Fundamental Knowledge Moderator: Thomas H. Maloney Discussants: Sally Elliott, Elena Ladich, George W. Vetrovec Session II. The Aortic Valve: A Deep Dive Moderator: Thomas H. Maloney Discussants: Polly Keller, Susheel Kodali, Tim J. Lapp 1:30 pm - Fundamental Knowledge: Aortic Valve Anatomy, Function, and Relational Pathology Polly Keller 1:50 pm - Hemodynamics and Interactive Calculations for Aortic Stenosis Using the John Madden Telestrator Tim J. Lapp 2:10 pm - Cardiologist s Perspective: How I Use Anatomical and Hemodynamic Data in Clinical Decision Making Susheel Kodali 2:30 pm - Discussion with Q&A Session III. The Mitral Valve: A Deep Dive Moderator: Thomas H. Maloney Discussants: Jeff Davis, Scott Lim, Tim R. Martin 2:40 pm - Fundamental Knowledge: Mitral Valve Anatomy, Function, and Relational Pathology Tim R. Martin 3:00 pm - Hemodynamics and Interactive Calculations for Mitral Stenosis and Mitral Regurgitation Using the John Madden Telestrator Jeff Davis 3:20 pm - Cardiologist s Perspective: How I Use Anatomical and Hemodynamic Data in Clinical Decision Making Scott Lim 3:40 pm - Discussion with Q&A Session IV. Bioskills Session: Anatomical Dissection for Structural Heart Therapies Moderators: Marsha Holton, John R. Zimmerman Chronic Total Occlusions: Evolutionary Approaches 8:00 am-5:57 pm Ballroom A This session is only CME accredited. Session I. CTO PCI: Introduction to a Skillset Moderators: Carlo Di Mario, Barry D. Rutherford Discussants: Greg L. Kaluza, Masahiko Ochiai, Ashish Pershad, Stéphane Rinfret, Bradley H. Strauss, Satoru Sumitsuji, Etsuo Tsuchikane, Patrick L. Whitlow 8:00 am - Angiographic Evaluation to Determine Procedural Approach Ashish Pershad 8:10 am - Does CT for CTO Planning Help Improve Success and Efficiency? Masahiko Ochiai 8:20 am - IVUS Interpretation During CTO PCI: True and False Lumen Discrimination, Identifying the Proximal Cap, and More Satoru Sumitsuji 8:32 am - The CTO Toolbox: What Do I Need in the Lab? Emmanouil S. Brilakis 8:40 am - Preparation and Role of the Cath Lab Staff for CTO PCI Stéphane Rinfret 8:48 am - CTO Case Volumes and the Learning Curve: Insights from the European CTO Registry Carlo Di Mario 8:58 am - J-PROCTOR: A Multicenter Registry Evaluating the Clinical Outcomes of Antegrade vs. Retrograde Approaches Etsuo Tsuchikane 9:08 am - ACE-CTO: Angiographic Follow-up After Everolimus-Eluting Stents in CTO Emmanouil S. Brilakis 53

56 Monday, October 22 9:18 am - Ad Hoc vs. Planned PCI: The Case for Staged Procedures Patrick L. Whitlow 9:28 am - What Can We Learn from Novel CTO Models? Greg L. Kaluza 9:36 am - Pharmacologic Lesion Modification: Status Update Bradley H. Strauss 9:42 am - Discussion with Q&A Session II. Barriers to CTO PCI: Myth Busters Moderators: J. Aaron Grantham, Masahiko Ochiai Discussants: M. Nicholas Burke, James B. Hermiller Jr, Dimitri Karmpaliotis, Yves R. Louvard, James Spratt, Gregg W. Stone, Gerald S. Werner 10:04 am - Justifying CTO PCI in the Era of Evidence-Based Medicine and Appropriate Use Criteria J. Aaron Grantham 10:19 am - Is the Complication Rate Too High to Justify the Procedure? Real Data of the Safety for PCI, Surgery, and Medical Therapy for CTO Gerald S. Werner 10:31 am - New Insights into the Importance of Incomplete Revascularization Giora Weisz 10:43 am - Can CTO PCI Only Be Accomplished by Technical Masters? The Case for Skillsets vs. Skills James Spratt 10:53 am - Is CTO PCI from the Radial Artery Too Complex? Yves R. Louvard 11:03 am - Can the Experienced Operator in a Busy Practice Learn the CTO Skillset? James B. Hermiller Jr 11:13 am - The Clinical Business Model for CTO PCI in the United States: Do Procedure Time, Reimbursement, and Costs Preclude Development of CTO PCI Programs? Dimitri Karmpaliotis 11:25 am - Interventionalist to Interventionalist Referral for PCI: A Viable Specialty Triage Mechanism or Zone of Repugnance? M. Nicholas Burke 11:35 am - Discussion with Q&A Session III. Geographic Differences in Approach to CTO PCI Moderators: Georgios Sianos, Gregg W. Stone Discussants: Osamu Katoh, Craig A. Thompson, Gerald S. Werner 11:50 am - Japanese Approach to Anatomy and Teaching Osamu Katoh 12:05 pm - European Approach to Anatomy and Teaching Gerald S. Werner 12:20 pm - Hybrid US Approach to Anatomy and Teaching Craig A. Thompson 12:35 pm - Discussion with Q&A Session IV. Technical Approaches for CTO PCI Moderators: Craig A. Thompson, Patrick L. Whitlow Discussants: Tony J. DeMartini, Carlo Di Mario, J. Aaron Grantham, Kazuaki Mitsudo, Masahiko Ochiai, Barry D. Rutherford, Etsuo Tsuchikane, R. Michael Wyman 12:50 pm - Antegrade CTO Wiring Strategy and Technique Masahiko Ochiai 1:05 pm - Antegrade Dissection and Reentry J. Aaron Grantham 1:20 pm - Retrograde Techniques: From Collateral Wiring to Corsair Management R. Michael Wyman 1:35 pm - Retrograde Dissection and Reentry: Reverse CART and CART Etsuo Tsuchikane 1:50 pm - Approach to the Case with Limited/No Retrograde Options Carlo Di Mario 2:05 pm - Approach to the Case with Limited/No Antegrade Options Tony J. DeMartini 2:20 pm - When to Accept Failure (and How to Prepare for a Reattempt) Barry D. Rutherford 2:35 pm - Discussion with Q&A Session V. Complications of CTO PCI: Prevention and Management Moderators: Carlo Briguori, R. Michael Wyman Discussants: Yasushi Asakura, Stephen Balter, Charles Chan, Alfredo R. Galassi 2:50 pm - Radiation Injury: Prevention, Consequences, and Mitigation Stephen Balter 3:05 pm - Contrast Nephropathy: Risk Scores and Prophylaxis Carlo Briguori 3:20 pm - Specific Antegrade Complications Yasushi Asakura 3:35 pm - Specific Retrograde Complications Alfredo R. Galassi 3:50 pm - Discussion with Q&A Session VI. Case Presentations with Discussion Moderators: Tony J. DeMartini, Gerald S. Werner Discussants: Sameer I. Dani, Debabrata Dash, Paul Hsien-Li Kao, Yves R. Louvard, Samuel K. Mathew, Toshiya Muramatsu, Sunao Nakamura, Alexander Grigorievich Osiev, Jochen Wöhrle 4:05 pm - Case 1: An Antegrade Success That Changed My Clinical Practice Simon Walsh 4:19 pm - Case 2: A Retrograde Success That Changed My Clinical Practice Ashish Pershad 4:33 pm - Case 3: An Antegrade Failure That Changed My Clinical Practice Satoru Sumitsuji 4:47 pm - Case 4: A Retrograde Failure That Changed My Clinical Practice Georgios Sianos 5:01 pm - Case 5: An Impossible Case Success That Changed My View of CTO PCI Toshiya Muramatsu 5:15 pm - Case 6: A Complication That Changed How I Perform CTO PCI Masahiko Ochiai 5:29 pm - Case 7: What I Learned from a Case That Went Longer Than Four Hours Alfredo R. Galassi 5:43 pm - Case 8: A Previous Failure That Succeeded Two Years Later: What Changed? J. Aaron Grantham 5:57 pm - Adjourn Core Training Curriculum in Clinical Research 8:00 am-4:00 pm Room A Session I. How to Establish and Maintain a Successful Research Program Moderators: David A. Cox, Giora Weisz Discussants: Priyadarshini Arambam, Kate Dalton, Theresa Franklin-Bond, Timothy D. Henry, James B. Hermiller Jr, D. Christopher Metzger, Thomas D. Stuckey 8:00 am - Welcome and Introduction: Objectives of this Session Giora Weisz 8:05 am - Why Do Clinical Research? The Pros and Cons Thomas D. Stuckey 8:15 am - How to Establish a Viable Clinical Research Program in Your Hospital: Essential First Steps and Standards Timothy D. Henry 54

57 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics 8:25 am - How to Handle and Improve Efficiencies in Your Institution with IRB, Budgets, and Contracts: The Cardinal Rules Giora Weisz 8:35 am - The Perfect Site: Improve Processes, Enhance Enrollment, and Score High! James B. Hermiller Jr 8:50 am - Screening Patients for Clinical Trial Eligibility: The Painful but Essential Step David A. Cox 9:00 am - Informed Consent: Difficult Case Scenarios Theresa Franklin-Bond 9:10 am - Quality Control: Investigator s Responsibilities Alexandra J. Lansky 9:20 am - How to Handle Monitoring Visits and Audits Kate Dalton 9:30 am - Discussion with Q&A Session II. Investigator-Initiated Research Moderators: David F. Kong, Paul S. Teirstein Discussants: Andrew Farb, David E. Kandzari, Charles A. Simonton, Ron Waksman 9:50 am - Industry-Sponsored vs. Investigator- Initiated Research: Similarities, Differences, and Pathways to Success David E. Kandzari 10:05 am - Research Ideas, Writing a Protocol: Key Elements Ron Waksman 10:15 am - When Is an IDE/IND Required for Investigator-Initiated Research? Andrew Farb 10:25 am - How to Apply for and Receive Industry Funding for Investigator-Initiated Research Charles A. Simonton 10:35 am - Discussion with Q&A Session III. Clinical Trial Interpretation: Pitfalls and Practical Lessons Moderator: Roxana Mehran Discussants: Giuseppe Biondi Zoccai, Somjot S. Brar, David J. Cohen, Sanjay Kaul, Ajay J. Kirtane, Helen Parise, Nico H.J. Pijls 10:50 am - Randomized Trials vs. Observational Studies: Advantages and Pitfalls Roxana Mehran 11:00 am - Discussion with Q&A 11:05 am - Composite Endpoints in Clinical Trials: Why Do We Need Them and How Do You Interpret Them? Giuseppe Biondi Zoccai 11:15 am - Discussion with Q&A 11:20 am - Site Reported vs. Adjudicated Events: What s the Difference and Why Should I Care? Sanjay Kaul 11:30 am - Discussion with Q&A 11:35 am - Importance of Adequately Powered Studies in Clinical Medicine: Case Studies Sanjay Kaul 11:45 am - Discussion with Q&A 11:50 am - Noninferiority Exposed: Uses and Abuses Helen Parise 12:00 pm - Discussion with Q&A 12:05 pm - Meta-analyses: Strengths and Weaknesses Ajay J. Kirtane 12:15 pm - Discussion with Q&A 12:20 pm - An Introduction to Costeffectiveness Analyses: Who Pays (and Should They?) David J. Cohen 12:30 pm - Discussion with Q&A Session IV. Standardized Data Definitions, Risk Stratification, and Personalized Medicine Moderator: Laura Mauri Discussants: Sorin J. Brener, David J. Cohen, Andrew Farb, Alejandra Guerchicoff, Karen A. Hicks, Alexandra J. Lansky, Roxana Mehran The Importance of Standardized Data Elements and Definitions 12:35 pm - The FDA View Karen A. Hicks 12:40 pm - The Clinician s View Sorin J. Brener 12:45 pm - The Trialist s View Laura Mauri The CEC Process: Is Harmonization Needed? ARC and Others 12:50 pm - US Perspective Roxana Mehran 12:55 pm - EU Perspective Hector M. Garcia-Garcia 1:00 pm - FDA Perspective Andrew Farb 1:05 pm - The Utility of Risk Scores: How to Properly Interpret and Use Them Davide Capodanno 1:15 pm - Quality of Life: Should This Be the Key Parameter in Choosing Therapies? John A. Spertus 1:25 pm - Personalized Medicine: Current Tools and the Future of Clinical Research in Practice David J. Cohen 1:35 pm - Discussion with Q&A Session V. Multidisciplinary Clinical Research: Crossing the Borders Moderators: Ted E. Feldman, A. Pieter Kappetein Discussants: David H. Adams, Alaide Chieffo, Joseph N. Cosico, George D. Dangas, Alejandra Guerchicoff, Rebecca Tung Hahn, Saibal Kar, David F. Kong, Nicholas J. Lembo, Michael J. Mack, Lauren T. Privitera, Maurice E. Sarano, Mathew Williams part 1: The patient with Valvular Heart Disease 1:50 pm - How Do You Set Up a Clinical Research Program in Valvular Heart Disease: Crucial First Steps Maurice E. Sarano 2:00 pm - The Multidisciplinary Team: What Is Really Involved? Michael J. Mack 2:10 pm - The Imaging Team: Essential Component for Success Rebecca Tung Hahn 2:20 pm - How Do You Get Everyone Onboard? Bruce Bowers part 2: Why You Need a Multidisciplinary Heart TeaM 2:30 pm - Case Scenario 1: Transcatheter Aortic Valve Replacement Mathew Williams 2:40 pm - Case Scenario 2: Transcatheter Mitral Valve Repair Saibal Kar part 3: CABG vs. PCI Trials: The Heart Team at Work 2:50 pm - Heart Team Logistics and Patient Selection Nicholas J. Lembo 3:00 pm - Informed Consent Process A. Pieter Kappetein 3:05 pm - Screening and Enrollment Alaide Chieffo 3:10 pm - Follow-up Joseph N. Cosico 3:15 pm - Discussion with Q&A monday - October 22,

58 Monday, October 22 Part 4: Renal Denervation Studies for Hypertension 3:25 pm - Patient Selection Krishna J. Rocha-Singh 3:35 pm - Informed Consent Lauren T. Privitera 3:40 pm - Screening and Enrollment George D. Dangas 3:45 pm - Nuances of Unblinded vs. Blinded Follow-up Procedures David F. Kong 3:50 pm - Discussion with Q&A 4:00 pm - Adjourn Endovascular Intervention 2012 (Part 1) 8:00 am-6:21 pm Room A This session is only CME accredited. Session I. Carotid Intervention I Moderators: Tyrone J. Collins, Lee R. Guterman Discussants: Tony Das, Sheldon Goldberg, Richard R. Heuser, R. Stefan Kiesz patient Selection 8:00 am - The Delphi Consensus and Its Validation: Guiding the Lesser Experienced Interventionalist on Patient Selection Sumaira Macdonald Rapid Fire: CAS Go and No-Go Patient Selection Algorithms 8:07 am - CAS Decision Making in Octogenarians Michel Camille Henry 8:13 am - CAS Decision Making in Women Isabelle Van Herzeele 8:19 am - CAS Decision Making in Recently Symptomatic Patients Sumaira Macdonald 8:25 am - CAS Decision Making in Asymptomatic Patients J. Michael Bacharach 8:31 am - CAS Decision Making in Difficult Aortic Arches D. Christopher Metzger 8:37 am - Discussion with Q&A Medical and Surgical Management Has a Role but When? 8:47 am - Which Asymptomatic Patients Benefit from CAS or CEA? Peter A. Schneider 8:54 am - What Is Optimal Medical Management for Carotid Disease, and What Residual Risk Remains Without Revascularization? Michael R. Jaff 9:01 am - Are CEA Outcomes Continuing to Improve? Evolution of a 60-Year-Old Procedure Takao Ohki 9:08 am - Discussion with Q&A Rapid Fire: CAS Techniques from the Experts 9:15 am - Managing the Tortuous Arch Alberto Cremonesi 9:20 am - Managing the Tortuous Carotid Peter A. Schneider 9:25 am - Step-by-Step Tips for Filter Deployment and Retrieval Thomas A. Ischinger 9:30 am - Step-by-Step Tips for the WL Gore NPS Flow Reversal System Juan C. Parodi 9:35 am - Step-by-Step Tips for the Mo.Ma (Medtronic) Proximal Occlusion System Bernhard Reimers 9:40 am - Step-by-Step Tips for the MICHI (Silk Road Medical) Direct Carotid Access System Sumaira Macdonald 9:45 am - Discussion with Q&A Session II. Carotid Intervention II Moderators: Robert M. Bersin, Bernhard Reimers Discussants: Klaus D. Mathias, Carlos I. Mena, Stephen R. Ramee, Isabelle Van Herzeele 21st Century Carotid Imaging 9:52 am - Advanced Cerebral Imaging (DWMRI, PET, Cerebral Perfusion): Role (If Any) in Patient Selection and Procedure Planning Alex Abou-Chebl 9:59 am - What Can Advanced Stent Imaging Tell Us About In-Stent Restenosis, Plaque Prolapse, and Design of Future Stents? Mark H. Wholey 10:06 am - Post-CAS Cerebral MRI Lesions: Frequency and Implications Sumaira Macdonald 10:13 am - Is Myocardial Infarction a Reasonable or Relevant Endpoint to Assess Carotid Intervention and Stroke Prevention Therapies in Clinical Practice and Trials? Carlos I. Mena 10:20 am - Discussion with Q&A Rapid Fire: CAS Top 5 Lists 10:25 am - Top 5 Things I Learned from Recent CAS Studies William A. Gray 10:30 am - Top 5 Tips to Make CAS Safer Klaus D. Mathias 10:35 am - Top 5 Ways to Educate and Improve the CAS Environment L. Nelson Hopkins 10:40 am - Top 5 Challenges Remaining in CAS Jay S. Yadav 10:45 am - Top 5 Blue-sky Wish List for CAS Device Improvements Daniel J. McCormick 10:50 am - Discussion with Q&A Case-Based Management in CAS Difficulties 10:57 am - Case 1: Slow Flow in a Filter Protection Case Jay S. Yadav 11:02 am - Case 2: Intolerance During Proximal Protection Robert M. Bersin 11:07 am - Case 3: Neurological Symptoms During the Procedure Max Amor 11:12 am - Case 4: Sheath Loses Position Gary M. Ansel facing the Future of CAS 11:17 am - Recanalization of Carotid Artery CTOs: Indications and Methods for a Controversial Procedure Paul Hsien-Li Kao 11:24 am - Optical Coherence Reflectometry: What Can It Tell Us About Our Technique and Our Equipment? Bernhard Reimers 11:31 am - The Impact of CAS on Neurocognitive Function Oscar A. Mendiz 11:38 am - CAS Following CREST: Now That the Noise Has Settled, What Is the Role of the Therapy? Herbert D. Aronow 11:45 am - Designing the Perfect Trial: Addressing the Remaining Critical Issues in CAS Peter A. Schneider 11:52 am - Update on the Only Remaining Carotid Multicenter Randomized International Trial in the World: ACST 2 Alison Halliday 56

59 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics 11:59 am - What Data Will Be Available and When? An Overview of the Progress of ACST 2, SPACE 2, and ECST 2 Studies Alison Halliday 12:06 pm - Discussion with Q&A Session III. Renal and Visceral Intervention Moderators: Lawrence A. Garcia, John H. Rundback Discussants: Mark C. Bates, Adam Geronemus, Thosaphol Limpijankit, Mark H. Wholey Visceral 12:13 pm - Endovascular Approaches to Acute and Chronic Mesenteric Ischemia Adam Geronemus 12:20 pm - Diagnosis and Technical Management of Renal and Visceral Aneurysms Ripal T. Gandhi 12:27 pm - Management of Mesenteric Arteries in EVAR Jacques Busquet 12:34 pm - Discussion with Q&A Renal 12:39 pm - Role of Renal Revascularization in 2012 and Predictions for the Future Michael R. Jaff 12:46 pm - Selecting the Patient Most Likely to Benefit from Renal Intervention Massoud A. Leesar 12:53 pm - Treating Fibromuscular Dysplasia in the Renal Artery Robert A. Lookstein 1:00 pm - Avoiding Complications in Renal Artery Stenting: Lessons from a Master Mark C. Bates 1:07 pm - DES for Vascular Erectile Dysfunction: Follow-up from the ZEN First-in-Man Study Krishna J. Rocha-Singh 1:14 pm - Discussion with Q&A 1:41 pm - Debate 2: Should Renal Artery Stenting Only Be Done Using FFR and IVUS? Con! Christopher J. White 1:46 pm - Debate 2: Discussion and Vote Session IV. Venous Intervention Moderators: Raghu Kolluri, Greg Mishkel Discussants: Anthony J. Comerota, Paul H. Kramer, Lindsay S. Machan, Thomas O. McNamara Overview and Latest Developments 1:51 pm - The Clinical Epidemiology of Venous Thrombosis and Thromboembolism: A Primer for the Interventionalist Raghotham R. Patlola 1:58 pm - DVT of the Upper Extremity: When and How to Initiate Pharmacologic and Mechanical Modes of Therapy Greg Mishkel 2:05 pm - The Importance of Central Venous Occlusion, Techniques for Intervention, and Long-term Expectation of Outcomes Michael D. Dake 2:12 pm - Thoracic Outlet Syndrome: Diagnosis and Management Jacques Busquet 2:19 pm - Methods for Successful Endovascular Management of Iliofemoral DVT Robert A. Lookstein 2:26 pm - Diagnostic Testing of, Indications for, and Endovascular Approaches to Venous Obstruction in the Pelvis Raghu Kolluri 2:33 pm - Update on CCSVI: Are We Any Closer to Understanding This Entity and Its Therapy? Michael D. Dake 2:40 pm - Discussion with Q&A 3:07 pm - Debate 2: Is Aggressive Endovascular Treatment of Pulmonary Embolism Justified? Con! Thomas O. McNamara 3:12 pm - Debate 2: Discussion and Vote Session V. Aortic Intervention Moderators: Jacques Busquet, Takao Ohki Discussants: Robert M. Bersin, Hugo F. Londero, Eric E. Roselli, Christopher K. Zarins Overview and Latest Developments 3:17 pm - Next-Generation of AAA EVAR Grafts: Iterative or Transformative? Robert M. Bersin 3:24 pm - Chimney and Snorkel Techniques: A Primer Takao Ohki 3:31 pm - The Final Frontier: Progress Report in Ascending Aorta and Arch Endografting Grayson H. Wheatley 3:38 pm - Managing the Type II Endoleak: Watchful Waiting but Then Which Intervention? Barry T. Katzen 3:45 pm - Branch or Embolize? Managing Iliac Aneurysms Involving the Hypogastrics James F. McKinsey 3:52 pm - Final Results from the Lombard Pythagoras Study for Angled Neck Abdominal Aneurysms William A. Gray 3:59 pm - Discussion with Q&A Mini-Debates 4:09 pm - Debate: Do the Data Support Endovascular Therapy for Descending Thoracic Aortic Dissections? Pro! Eric E. Roselli 4:14 pm - Debate: Do the Data Support Endovascular Therapy for Descending Thoracic Aortic Dissections? Con! Christoph A. Nienaber 4:19 pm - Debate: Discussion and Vote monday - October 22, 2012 Mini-Debates 1:21 pm - Debate 1: Is Embolic Protection Mandatory in Renal Artery Stenting? Pro! Michel Camille Henry 1:26 pm - Debate 1: Is Embolic Protection Mandatory in Renal Artery Stenting? Con! Christopher J. Cooper 1:31 pm - Debate 1: Discussion and Vote 1:36 pm - Debate 2: Should Renal Artery Stenting Only Be Done Using FFR and IVUS? Pro! Mehdi H. Shishehbor Mini-Debates 2:47 pm - Debate 1: Is a Strategy of Endovascular Thrombus Resolution Best for Iliofemoral DVT? Pro! Anthony J. Comerota 2:52 pm - Debate 1: Is a Strategy of Endovascular Thrombus Resolution Best for Iliofemoral DVT? Con! Erich Minar 2:57 pm - Debate 1: Discussion and Vote 3:02 pm - Debate 2: Is Aggressive Endovascular Treatment of Pulmonary Embolism Justified? Pro! Gary M. Ansel Session VI. Iliac and Superficial Femoral Artery Intervention Moderators: Gary M. Ansel, Barry T. Katzen Discussants: Mark W. Burket, Hans Krankenberg, David Planer, Craig M. Walker Overview and Latest Developments 4:24 pm - Final Data on the ICARUS Trial of Covered Stents for Obstructive Iliac Disease John R. Laird Jr 4:31 pm - What is the Potential Economic Impact of Antiproliferative Technologies in the SFA? Mark W. Burket 57

60 Monday, October 22 4:38 pm - Drug-Coated Balloons for SFA In-Stent Restenosis: A Simple Solution for a Tenacious Problem? Eugenio Stabile 4:45 pm - Drug-Coated Balloons and Atherectomy: Additive, Synergistic, or Without Advantage? Luigi Salemme 4:52 pm - Update on Important SFA Therapies: VIBRANT, VIPER, and Zilver PTX Studies Gary M. Ansel 4:59 pm - What is the Current Role of Metal Prostheses in the SFA? Master Perspectives Giancarlo Biamino 5:06 pm - Expanding the Borders: Endovascular Intervention for Common Femoral and Popliteal Disease Thomas Zeller 5:13 pm - Development of a Bioresorbable Scaffold for the SFA Richard J. Rapoza 5:20 pm - Adventitial Injection for SFA Restenosis: Results of an Exploratory Study Christopher D. Owens 5:27 pm - A Modern Algorithm for Noninvasive Testing Following Lower Extremity Vascular Stenting Michael R. Jaff 5:34 pm - Final 12-Month Outcomes from the SUPERB Trial Using the Supera Woven Nitinol Stent Lawrence A. Garcia 5:41 pm - Discussion with Q&A Mini-Debates 5:51 pm - Debate 1: Are Drug-Eluting Stents Now the Default Strategy for SFA Intervention? Pro! Gary M. Ansel 5:56 pm - Debate 1: Are Drug-Eluting Stents Now the Default Strategy for SFA Intervention? Con! Lawrence A. Garcia 6:01 pm - Debate 1: Discussion and Vote 6:06 pm - Debate 2: Should Embolic Protection Be Mandatory in Lower Extremity Intervention? Pro! D. Christopher Metzger 6:11 pm - Debate 2: Should Embolic Protection Be Mandatory in Lower Extremity Intervention? Con! Mark W. Burket 6:16 pm - Debate 2: Discussion and Vote 6:21 pm - Adjourn Interventional Innovation: Novel Therapies and the Best New Device Concepts for :00 am-6:15 pm Room A This session is not CME/CNE accredited. Session I. Innovation in Transition Moderators: Elazer R. Edelman, Barry T. Katzen Discussants: Rick Anderson, Sanjeev Bhatt, John M. Capek, Andrew Farb, Peter J. Fitzgerald, Thomas J. Fogarty, Aaron V. Kaplan, Mitchell W. Krucoff, Hank Kucheman, Martin B. Leon, Chaim S. Lotan, Martin T. Rothman, Sean Salmon, Jacques Seguin, Mark A. Turco Keynote Lectures 8:00 am - Is Innovation in the United States on the Road to Recovery? An Interim Analysis and Critique Elazer R. Edelman 8:15 am - A Collaborative Multidisciplinary Approach to Medical Innovation John M. Capek 8:30 am - New FDA Innovation Pathways and Initiatives Andrew Farb 8:45 am - The Globalization of Innovation Is Here to Stay: Reasons, Realities, and Consequences Mitchell W. Krucoff 9:00 am - From Hardware (Devices) to Software (Information Technology): How the Digital Revolution Will Change Medical Innovation Peter J. Fitzgerald 9:15 am - Discussion: Transitional Challenges Session II. The Cath Lab of the Future Moderators: John D. Carroll, Horst Sievert Discussants: Jorge A. Belardi, Elchanan Bruckheimer, Louis A. Cannon, Run-Lin Gao, Samir R. Kapadia, Jacques J. Koolen, John A. Ormiston, Augusto D. Pichard, Ashok Seth, Samin K. Sharma New Clinical Targets 9:30 am - Taped Case 1: Use of the Covidien OneShot Renal Denervation System for Hypertension John A. Ormiston 9:45 am - TCT-105. Long-term Intravascular Blood Pressure Monitoring with a Novel Wireless Sensor System: Results from Chronic In-Vivo Studies Nina Cleven 9:53 am - Discussion with Q&A Telemanipulation and Robotics 9:55 am - Taped Case 2: The Corindus Robotic-Assisted Coronary Angioplasty System Giora Weisz Multiple Imaging Modalities 10:10 am - The RealView Holographic Imaging System for Adult Congenital, Structural, and Valvular Heart Disease Elchanan Bruckheimer 10:20 am - Magnetic Resonance Imaging Guidance During Interventional Cardiovascular Procedures Robert J. Lederman 10:30 am - A Visionary Look at the Cath Lab in 2020: Multispecialty, Multiple Imaging Modalities, Multiple Clinical Targets, Fully Integrated, and IT Enabled: A Cardiovascular Diagnostic and Therapeutic Melting Pot Martin B. Leon 10:45 am - Discussion: The Cath Lab of the Future Session III. The Inventor s Workshop 2012 Moderators: Thomas J. Fogarty, Julio C. Palmaz Discussants: Louis A. Cannon, Keith D. Dawkins, Peter J. Fitzgerald, Rick Geoffrion, L. Nelson Hopkins, Ran Kornowski, Hank Kucheman, Casey McGlynn, Semih Oktay, Stanton J. Rowe, Jacques Seguin, Richard S. Stack, Uri Yaron 11:00 am - Lessons from the Stanford Biodesign Program: Creating a Culture and Teaching a Process Peter J. Fitzgerald 11:10 am - TCT-106. BioInnovate Ireland: A Multidisciplinary Approach to Medical Device Innovation Mark Bruzzi 11:18 am - Discussion 11:20 am - The Israeli Start-up Nation Approach to Medical Innovation: Defining the Ecosystem Ran Kornowski 11:30 am - Discussion A Stepwise Primer on Medical Device Innovation 11:30 am - Step 1: Needs Assessment Louis A. Cannon 11:40 am - Step 2: Invention Richard S. Stack 11:48 am - Step 3: Intellectual Property Casey McGlynn 58

61 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics 11:56 am - Step 4: Preclinical Assessments Juan F. Granada 12:06 pm - Step 5: First-in-Human Use Alexandre Abizaid 12:14 pm - Step 6: Clinical Regulatory Pathways Semih Oktay 12:22 pm - Step 7: Funding Opportunities Rick Anderson Session IV. The Transcatheter Valve Therapy (TVT) Explosion: An Innovator s Dream Scenario Moderators: Eberhard Grube, Lars G. Svensson Discussants: Henning Rud Andersen, Shmuel Banai, Bernard R. Chevalier, Charles J. Davidson, Hans R. Figulla, Raj Makkar, Ganesh Manoharan, Stanton J. Rowe, Nicolas M. van Mieghem, Thomas Walther 1:00 pm - TVT Goes Viral: New Valve Systems and Accessory Devices Will Transform the Future Eberhard Grube 1:15 pm - Taped Case 3: Heterotopic Transcatheter Tricuspid Valve Implantation for Patients with Severe Tricuspid Regurgitation Hans R. Figulla 1:30 pm - TCT-107. A Novel Catheter-Based Mitral Valve Bioprosthesis: Short-term Preclinical Results Shmuel Banai 1:38 pm - Discussion 1:40 pm - TCT-108. Performance and Safety of the TRUE Dilatation Balloon Valvuloplasty Catheter for Aortic Balloon Valvuloplasty in Patients Undergoing TAVR Felix Woitek 1:48 pm - Discussion 1:50 pm - TCT-109. A New Generation Transcatheter Heart Valve with a Novel Nanocomposite Material and Fully Retrievable Design Benyamin Rahmini 1:58 pm - Discussion 2:00 pm - TCT-110. First Experience with a Novel Anatomically Adapted Percutaneous Heart Valve for the Tricuspid Position Desiree Pott 2:08 pm - Discussion 2:10 pm - TCT-111. First-in-Man Experience with a Two-Part Exchangeable Leaflet Bioprosthetic Valve Lars G. Svensson 2:18 pm - Discussion 2:20 pm - The Apica Left Ventricular Apical Access and Closure System: First-in-Human Use Experiences During TAVR Thomas Walther 2:30 pm - Discussion: Futuristic TVT Therapies Session V. Med-tech Meets Infotech: Synergistic Impact Moderators: Neal L. Eigler, Peter J. Fitzgerald Discussants: Robert Amyot, Yuval Binur, Roberto Botelho, Daniel Burkhoff, Rick Geoffrion, James K. Min, Sean Salmon, Frederick G. St. Goar 2:45 pm - Featured Lecture: Impact of Telemedicine on Patient Care: STEMI: A Global Case Study Roberto Botelho 3:00 pm - Discussion 3:05 pm - Can HeartFlow Change the Clinical Management Paradigm for Patients with Coronary Disease? James K. Min 3:20 pm - TCT-112. Two-way Real-time Interaction by Means of a Novel Telecommunications Software Improves Management of Patients with ST-Segment Elevation Myocardial Infarction Gabriel Sardi 3:28 pm - Discussion 3:30 pm - Advanced Simulation Tools for Physician Training and Case Planning Robert Amyot 3:40 pm - Hemodynamics for Dummies: A Novel ipad Application for Medical Education, Patient Selection, and Device Development Daniel Burkhoff 3:50 pm - Discussion: Med-tech Meets Infotech Session VI. Innovation for Mainstream Clinical Applications: Old Friends and Emerging Frontiers Moderators: Chaim S. Lotan, Renu Virmani Discussants: Alessandro S. Bortone, David Cormode, Keith D. Dawkins, Tim A. Fischell, Navin K. Kapur, Nicholas N. Kipshidze, Amir Lerman, Manish A. Parikh, Krishna J. Rocha-Singh, Mark H. Wholey Featured Lectures 4:00 pm - The Hottest New Cardiovascular Device Concepts from the Israeli Innovation Pipeline Chaim S. Lotan 4:15 pm - Exciting Cardiovascular Device Innovation from Europe: From Balloons to Stents to Closure Devices and More Alessandro S. Bortone Endovascular Horizons 4:30 pm - Taped Case 4: Complex Pelvic Reconstruction: Endovascular Treatment of Benign Prostatic Hypertrophy and Erectile Dysfunction Akaki Archvadze 4:45 pm - TCT-113. Focal Treatment of Lower Extremity Post-PTA Dissection Using the Tack-It Endovascular Stapler System: First-in-Man Trial with One-Year Follow-up Peter A. Schneider 4:53 pm - Discussion 4:55 pm - TCT-114. Feasibility of Noninvasive Atherectomy: Plaque Ablation with Cavitation-Based Focused Ultrasound (Histotripsy) Adam Maxwell 5:03 pm - Discussion Vulnerable Plaque Opportunities 5:05 pm - Intravascular Photoacoustics: Progress and Potential for Vulnerable Plaque Imaging Antonius F.W. van der Steen 5:15 pm - Emerging Applications of Nanotechnology for the Diagnosis and Management of Vulnerable Atherosclerotic Plaque David Cormode 5:25 pm - Simultaneous Localization and Treatment of Vulnerable Plaque by Tin-117m Conversion Electrons: First-in-Human Results Renu Virmani Interventional Heart Failure: The Next Big Breakthrough 5:35 pm - The Emergence of Interventional Heart Failure and Advanced Cardiac Support as an Important Clinical Subspecialty: Clinical Targets, Device Concepts, and Physician Training Navin K. Kapur 5:50 pm - Transcatheter Interatrial Shunt for Heart Failure with Preserved Ejection Fraction (HFPEF) Brad I. Munt monday - October 22,

62 Monday, October 22 6:00 pm - Discussion: Cardiovascular Innovation for Mainstream Applications 6:15 pm - Adjourn Left Main and Bifurcation Stenting: An Advanced Operator s Workshop 8:00 am-6:11 pm Junior Ballroom D This session is only CME accredited. Session I. Non-Left Main Bifurcation Stenting: Overviews Moderators: Yves R. Louvard, Leif Thuesen Discussants: Somjot S. Brar, Antonio Colombo, Nick Curzen, Debabrata Dash, Nicolas Foin, Liliana R. Grinfeld 8:00 am - Non-Left Main Bifurcation Stenting: Highlights from the Last 12 Months Nick Curzen 8:10 am - What Can Preclinical Models Teach Us About Bifurcation Stenting? Greg L. Kaluza 8:18 am - Bifurcation Anatomy, Angulation, and Lesion Complexity: Implications for Procedural Outcomes and Long-term Patency Debabrata Dash 8:26 am - Impact of Stent Design on Outcomes After Bifurcation Stenting Nicolas Foin 8:34 am - Non-Left Main Bifurcation Stenting: Updated Meta-analysis of Simple vs. Complex Techniques Somjot S. Brar Debate: What Is the Appropriate Frequency for Implanting Two Stents in Non-Left Main Bifurcation Lesions? 8:42 am - The Data Are Clear: The Careful Operator Should Implant Two Stents in No More Than 10% of Bifurcation Lesions! Liliana R. Grinfeld 8:49 am - Randomized Trials Don t Reflect the Real World: Two Stents Should Be Used in 50% of Bifurcation Lesions or More! Antonio Colombo 8:56 am - Discussion with Q&A Session II. Non-Left Main Bifurcation Stenting: Technique Practicum I Moderators: Issam D. Moussa, Terje K. Steigen Discussants: Vinay K. Bahl, Antonio L. Bartorelli, Carlo Briguori, Efrain Gaxiola, Angela Hoye, John M. Lasala, Afzalur Rahman 9:11 am - Provisional Stenting Technique: Step-by-Step Tutorial (Including Crossover Techniques) Yves R. Louvard 9:21 am - Provisional Stenting Technique Cases 1 and 2: Getting by with One Stent Only Francesco Burzotta 9:31 am - Provisional Stenting Technique Cases 3 and 4: Second Stent Needed (Before and After the First Stent) Jeffrey W. Moses 9:41 am - Planned Two-Stent Techniques: Step-by-Step Tutorial and Use Recommendations for T, Modified T, TAP, Mini-Crush, Culotte, SKS, V, and More David J. Hildick-Smith 9:56 am - Planned Two-Stent Technique Cases 5 and 6: Modified T and TAP Vladimír Džavík 10:06 am - Planned Two-Stent Technique Cases 7 and 8: Mini-Crush and Culotte Alaide Chieffo 10:16 am - Planned Two-Stent Technique Cases 9 and 10: SKS and V Samuel K. Mathew 10:26 am - Discussion with Q&A Session III. Non-Left Main Bifurcation Stenting: Technique Practicum II Moderators: Ioannis Iakovou, David G. Rizik Discussants: Carlo Di Mario, Gary Gershony, Bon-Kwon Koo, Alexandra J. Lansky, Akiko Maehara, Detlef G. Mathey 10:41 am - The Importance of Bifurcation Lesion Preparation and How to Do It Gary Gershony 10:49 am - Uses and Utility of IVUS During Bifurcation Stenting Akiko Maehara 10:57 am - Uses and Utility of OCT During Bifurcation Stenting Carlo Di Mario 11:05 am - Uses and Utility of FFR During Bifurcation Stenting Bon-Kwon Koo 11:13 am - Uses of Drug-Eluting Balloons for Coronary Bifurcation Lesions: Rationale, Data, and Practice Detlef G. Mathey 11:21 am - Importance of Sidebranch Closure After Bifurcation Stenting: When Should We Care? Alexandra J. Lansky 11:29 am - Discussion with Q&A Session IV. Dedicated Bifurcation Stents for Left Main and Non-Left Main Bifurcations Moderators: Jens Flensted Lassen, Ashok Seth Discussants: Alexandre Abizaid, Fernando Cura, Martin B. Leon, John A. Ormiston, David G. Rizik, Stefan Verheye 11:44 am - Rationale for Dedicated Bifurcation Stents, and a Proposed Classificiation John A. Ormiston 11:52 am - Dedicated Bifurcation Stents: Tryton Program Update Martin B. Leon 12:00 pm - Dedicated Bifurcation Stents: Cappella Program Update Fernando Cura 12:08 pm - Dedicated Bifurcation Stents: Biosensors Program Update Stefan Verheye 12:16 pm - Dedicated Bifurcation Stents: STENTYS Program Update Stefan Verheye 12:24 pm - Dedicated Bifurcation Stents: Xience SBA Program Update David G. Rizik 12:32 pm - Dedicated Bifurcation Stents: Minvasys Nile Program Update Alexandre Abizaid 12:40 pm - Discussion with Q&A Session V. Left Main Stenting: Overviews Moderators: David E. Kandzari, Friedrich W. Mohr Discussants: J. Matthew Brennan, Mauro Carlino, Ted E. Feldman, Young-Hak Kim, Takeshi Kimura, Tullio Palmerini, Patrick W. Serruys, Gregg W. Stone, Leif Thuesen, Marco Valgimigli 12:44 pm - Left Main Stenting: Highlights from the Last 12 Months David E. Kandzari 12:54 pm - SYNTAX Five-Year Results: Left Main Cohort Ted E. Feldman 1:04 pm - A Detailed Analysis of Stent Thrombosis from the SYNTAX Trial (All Patients and Left Main vs. Multivessel Disease Cohorts): Frequency, Timing, Vessel, and Contribution to Adverse Events Patrick W. Serruys 1:12 pm - Left Main PCI vs. CABG: Updated Bayasian Meta-analysis John A. Bittl 1:20 pm - Stroke After PCI vs. CABG (All Patients and Left Main Disease) Tullio Palmerini 60

63 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics 1:28 pm - Left Main PCI in the United States: Report from the NCDR J. Matthew Brennan 1:36 pm - Are the Outcomes of Left Main Stenting Improving with Second Generation Stents? Results of PRECOMBAT-2 Young-Hak Kim 1:44 pm - Case 1: Left Main Disease with Syntax Score >32: PCI vs. CABG Takeshi Kimura 1:52 pm - Case 2: Left Main Disease Plus Triple-Vessel Disease and Syntax Score <32: PCI vs. CABG Mauro Carlino 2:00 pm - The NOBLE Trial: Novel Aspects and Status Update Leif Thuesen 2:05 pm - The EXCEL Trial: Novel Aspects and Status Update Gregg W. Stone 2:10 pm - Discussion with Q&A Session VI. Risk Scores and the Heart Team Moderators: Anthony H. Gershlick, Patrick W. Serruys Discussants: Davide Capodanno, Jean Fajadet, Marie-Angele Morel, Samin K. Sharma, David Taggart 2:25 pm - The Syntax Score Tutorial: Step by Step and Common Mistakes Marie-Angele Morel 2:40 pm - From Syntax to Global Risk: Pros and Cons of Different Risk Scores Davide Capodanno Debate: Should a Syntax Score (or Other Risk Score) be Calculated Before Complex Left Main/Multivessel Disease Intervention? 2:50 pm - Yes: It s in the Guidelines, and It s Evidence-Based! Samin K. Sharma 2:57 pm - No: We Don t Need a Formal Scoring System, and We Know Complex Disease When We See It! Jean Fajadet Session VII. Left Main PCI Technique I: The Method Moderators: Seung-Jung Park, Simon Redwood Discussants: David Antoniucci, Antonio Colombo, Jean Fajadet, David J. Hildick-Smith, David E. Kandzari, Gary S. Mintz, Bernhard Reimers 3:30 pm - Ostial Left Main Disease: Techniques to Nail the Ostium Andrejs Erglis 3:38 pm - When Are Two Stents Not Needed for the Distal Left Main Bifurcation? David J. Hildick-Smith 3:46 pm - An Algorithm to Choose Between Different Two-Stent Techniques for the Distal Left Main Jean Fajadet 3:56 pm - Lesion Preparation of the Left Main Lesion: When and Which Device? Issam D. Moussa 4:04 pm - Simplifying PCI of Left Main Trifurcation Disease Antonio Colombo 4:12 pm - Use and Utility of FFR During Left Main Stenting Seung-Jung Park 4:20 pm - Use and Utility of IVUS During Left Main Stenting Gary S. Mintz 4:28 pm - Hemodynamic Support During Left Main PCI: When and Which Device? Simon Redwood 4:36 pm - Is Platelet Function Testing of Use Before Left Main PCI? David Antoniucci 4:44 pm - Frequency and Management of Left Main Restenosis Bernhard Reimers 4:52 pm - Discussion with Q&A 5:31 pm - Complex Left Main PCI with FFR at Multiple Steps William F. Fearon 5:39 pm - Complex Left Main PCI with IVUS at Multiple Steps Stéphane Rinfret 5:47 pm - Complex Left Main PCI Requiring Rotational Atherectomy Patrick L. Whitlow 5:55 pm - Complex Left Main PCI Requiring Hemodynamic Support Jan Harnek 6:03 pm - Left Main PCI During Acute Myocardial Infarction Jan Harnek 6:11 pm - Adjourn Strategies for Cardiovascular Repair: Stem Cells and Beyond 8:00 am-5:30 pm Room A :00 am - Overview and Introduction Warren Sherman Session I. Cardiovascular Repair: Molecular, Inflammatory, and Immunogenic Mechanisms Moderators: Stefanie Dimmeler, Stephen E. Epstein Discussants: Jonathan Leor, Jan J. Piek 8:10 am - MicroRNAs: Enhancers or Detractors of Progenitor Cell Function? Stefanie Dimmeler 8:25 am - Proinflammatory Responses and Acute Tissue Injury Jan J. Piek 8:40 am - Endogenous Stem Cell Repair in Response to Acute Injury Feng Dong 8:55 am - Discussion with Q&A monday - October 22, 2012 Debate: Should the Heart Team Meet Before All Cases of Left Main Intervention? 3:04 pm - Yes: It s in the Guidelines and Ensures Patient Consent and Optimal Treatment Decisions! David Taggart 3:11 pm - No: At Least Not for Simple Cases of Left Main Intervention! Paul S. Teirstein 3:18 pm - Discussion with Q&A Session VIII. Left Main PCI Technique II: The Cases Moderators: Antonio Colombo, Patrick L. Whitlow Discussants: Adrian P. Banning, Nirat Beohar, Pawel E. Buszman, Dietmar H. Glogar, Sheldon Goldberg, Duk-Woo Park, Ramon Quesada, Simon Walsh 5:07 pm - Medina 1,1,1 of the Distal Left Main Treated with One Stent Theodore A. Bass 5:15 pm - Medina 1,1,1 of the Distal Left Main: Tried One Stent, Needed Two Nicholas J. Lembo 5:23 pm - Medina 1,1,1 of the Distal Left Main: Which Planned Two-Stent Technique? Andrejs Erglis Session II. New and Renewed Approaches to Growth Factor Therapy Moderators: Henricus J. Duckers, Stephen E. Epstein Discussants: Elazer R. Edelman, Jonathan Leor, Wojciech Wojakowski 9:15 am - Allogenic MSC Overexpressing HO-1 Gene in Pig Model of Acute MI Wojciech Wojakowski 9:30 am - IGF-1 and HGF from an Injectable Alginate Jonathan Leor 9:45 am - Novel Biodelivery Strategies for Tissue Ischemia and Dysfunction Elazer R. Edelman 10:00 am - Discussion with Q&A 61

64 Monday, October 22 Session III. Optimizing Delivery and Retention Moderator: Warren Sherman, Jorge Tuma Discussants: Nabil Dib, Henricus J. Duckers, Amit Patel, Andreas M. Zeiher 10:20 am - Safety of the Stop-flow Intracoronary Technique: Single-center Experience Andreas M. Zeiher 10:32 am - A New Device for Intracoronary Infusion Nabil Dib 10:44 am - IM Delivery: Current and Future Status Warren Sherman 10:56 am - Retrograde Coronary Injection: Current and Evolving Status Amit Patel 11:08 am - Fiberoptic Cardioscopy for Use in Epicardial Injection of Cell Suspensions and Biomaterials Henricus J. Duckers 11:20 am - Discussion with Q&A Session IV. Clinical I: Chronic Symptomatic Ischemia Moderators: Amit Patel, Andreas M. Zeiher Discussants: Francisco Fernandez-Aviles, Timothy D. Henry, Thomas J. Povsic 11:40 am - Gene Therapy for Peripheral Arterial Disease: Status Update Timothy D. Henry 11:55 am - Phase II and III Clinical Trials: Off and Running! Amit Patel 12:10 pm - Mobilized CD 34+ Cells for Refractory Angina Thomas J. Povsic 12:25 pm - Combined G-CSF and Intramyocardial Injection of Autologous Bone Marrow Mononuclear Cells in Ischaemic Heart Failure Improves Cardiac Function and Symptoms at One-Year: Results of a Randomized Clinical Trial Anthony Mathur 12:40 pm - Precise Trial Results: Adipose Derived Cells for CMI Francisco Fernandez-Aviles 12:55 pm - Discussion with Q&A Session V. Clinical II: Acute Myocardial Injury Moderators: Jozef Bartunek, Hyo-Soo Kim Discussants: Henricus J. Duckers, Warren Sherman, Jochen Wöhrle, Andreas M. Zeiher 1:15 pm - Perivascular MAPCs: Long-term Follow-up and Next Steps Warren Sherman 1:30 pm - Mechanisms of Stem Cell Effects: Insights from MRI in the SCAMI Trial Jochen Wöhrle 1:45 pm - AMICI: Use of Mesenchymal Precursor Cells in the Treatment of STEMI Patients (FIM/IIB Study) Henricus J. Duckers 2:00 pm - Bone Marrow Cell Transfer for STEMI: The BAMI Program Progress Report Andreas M. Zeiher 2:15 pm - Discussion with Q&A Session VI. Stem Cells for Cardiac Repair in the Chronic Setting Moderators: Emerson C. Perin, Warren Sherman Discussants: Jozef Bartunek, Timothy D. Henry, Amit Patel, Marc S. Penn 2:35 pm - SDF-1: Circumventing the Application of Cell Products in Heart Failure Warren Sherman 2:50 pm - Retrograde Application of Autologous BM Cells: Phase 2 Study Results Amit Patel 3:05 pm - Lineage Specified Mesenchymal Cells for HF: C-Cure Update Jozef Bartunek 3:20 pm - Allogenic Cells for Chronic Left Ventricular Dysfunction: US Experience and Beyond Emerson C. Perin 3:35 pm - Ixmyelocel-T for CHF: Results of Catheter-Based Study Timothy D. Henry 3:50 pm - Discussion with Q&A Session VII. Defining Clinical Strategies and New Directions Moderators: Warren Sherman, Andreas M. Zeiher Discussants: Stephen G. Ellis, Stephen E. Epstein, Joshua M. Hare, Hyo-Soo Kim, Raj Makkar 4:10 pm - CCTRN: Second Cycle Studies Emerson C. Perin 4:22 pm - Autologous vs. Allogeneic Cardiac Stem Cells: The Allstar Trial Raj Makkar 4:34 pm - Endpoint Selection: Focus on STEMI Stephen G. Ellis 4:46 pm - Stents and Vascular Healing: New Concepts Hyo-Soo Kim 4:58 pm - The Evolution of a Stem Cell-Based Strategy: From Enhanced Collateral Function to Wound Healing Stephen E. Epstein 5:10 pm - Discussion with Q&A 5:30 pm - Adjourn The Drug-Eluting Stent Summit: Appropriate Utilization of Current Generation Devices 8:00 am-6:03 pm Hall A-Coronary Theater This session is only CME accredited. Session I. Keynote Address Moderator: Martin B. Leon 8:00 am - DES the Year in Review: Trends, Utilization, Science, and Controversies Martin B. Leon Session II. The Emergence of Neoatherosclerosis as a Major Contributor to Late Stent Outcomes Moderators: Juan F. Granada, Seung-Jung Park Discussants: Marco A. Costa, Hector M. Garcia-Garcia, Michael Joner, Gary S. Mintz, Pedro R. Moreno, Patrick W. Serruys 8:12 am - Neoatherosclerosis After BMS and DES: Pathologic Insights Renu Virmani 8:20 am - Neoatherosclerosis After BMS and DES: Experimental Insights Greg L. Kaluza 8:28 am - Imaging Studies of Late Restenosis and/or Stent Thrombosis: Is Neoatherosclerosis the Final Common Pathway of DES Failure? Soo-Jin Kang 8:38 am - Neoatherosclerosis Mediated Plaque Vulnerability and Periprocedural Myocardial Infarction Ziad A. Ali 8:46 am - Case Presentation: Neoatherosclerosis and Its Sequelae Marco A. Costa 8:56 am - Discussion with Q&A Session III. Stent Trial Updates and Meta-analyses from the Major DES Programs Moderators: Ian T. Meredith, Stephan Windecker Discussants: Herbert D. Aronow, Bernard R. Chevalier, Upendra Kaul, Jens Flensted Lassen, Miodrag C. Ostojic, Duk-Woo Park, Philip M. Urban, Alan C. Yeung 9:06 am - TAXUS: Final Five-Year SYNTAX Results (Entire Study Population) Patrick W. Serruys 9:16 am - PROTECT: Three-Year Results of a Randomized Mega-trial of Endeavor vs. Cypher Edoardo Camenzind 62

65 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics 9:26 am - Everolimus-Eluting Stents: SPIRIT and PLATINUM Update Gregg W. Stone 9:36 am - Multiple DES: Latest Results from the COMPARE I and II Trials Peter C. Smits 9:46 am - RESOLUTE All-Comers at Three Years Sigmund Silber 9:51 am - BIOMATRIX: Final Five-Year LEADERS Results Patrick W. Serruys 9:56 am - Stent Thrombosis Meta-analysis Tullio Palmerini 10:03 am - DES Clinical Outcomes Meta-analysis Sripal Bangalore 10:10 am - Discussion with Q&A Session IV. PCI and DES in Stable Ischemic Heart Disease Moderators: David J. Cohen, John A. Spertus Discussants: Sripal Bangalore, William E. Boden, Rory Hachamovitch, John McB. Hodgson, Azeem Latib, Ahmed Magdy, David J. Maron, Jeffrey W. Moses 10:25 am - Are COURAGE and FAME Irrelevant (or Less Relevant) with Current Generation DES? Dean J. Kereiakes Debate: Identifying the Threshold for PCI and DES in Stable Ischemic Heart Disease 10:35 am - Position 1: Use PCI and DES Sparingly, and If at All, Only After OMT Truly Fails! David Brown 10:43 am - Position 2: If PCI Is Required, Use BMS for Low-Risk TVR Lesions! John A. Spertus 10:51 am - Position 3: Ischemia Matters: Use PCI with DES Principally to Eliminate Ischemia! Bernard De Bruyne 10:59 am - Position 4: Patient Preference Matters: Use PCI with DES Early and Liberally in Most Patients! Ajay J. Kirtane 11:07 am - Discussion with Q&A 11:22 am - Case Presentation (with Discussion): DES vs. BMS vs. OMT in Stable Ischemic Heart Disease Frederick Feit Session V. DES in Complex Lesion Subsets Moderators: Antonio Colombo, Paul S. Teirstein Discussants: Pawel E. Buszman, John M. Lasala, Alfredo Rodriguez, Giuseppe M. Sangiorgi, Glenn Van Langenhove, Simon Walsh 11:32 am - Bifurcation and Left Main Disease: Technical Approaches to Optimize Long-term Outcomes Philippe Garot 11:47 am - Case Presentation (with Discussion): Distal Left Main Bifurcation Technique Jean Fajadet 11:57 am - Case Presentation (with Discussion): Non-Left Main True Bifurcation Technique John M. Lasala 12:07 pm - Multivessel Disease 1: Final Five-Year SYNTAX Results in the MVD Cohort A. Pieter Kappetein 12:17 pm - Multivessel Disease 2: Use of Physiologic Lesion Assessment and IVUS to Improve DES Results Seung-Jung Park 12:27 pm - Case Presentation (with Discussion): Complex Multivessel Intervention with FFR and IVUS Bon-Kwon Koo 12:37 pm - Calcified Lesions: New Insights in Stable CAD and ACS from Large-Scale Clinical Trials Philippe Généreux 12:47 pm - Case Presentation (with Discussion): Decalcification with the Orbital Atherectomy System Jeffrey Chambers 12:57 pm - Restenosis After Coronary Stenting in 10,004 Patients with Follow-up Angiography Salvatore Cassese 1:07 pm - DES Restenosis: Treatment Options and Recurrent Event Rates Alaide Chieffo 1:17 pm - Case Presentation (with Discussion): Recurrent DES Restenosis Simon Walsh 1:27 pm - DES Thrombosis: Acute Evaluation and Management for Short-term Success and Late Prevention Huay Cheem Tan 1:37 pm - Case Presentation (with Discussion): Recurrent DES Thrombosis Jose M. de la Torre Hernandez Session VI. Antiplatelet Therapy Decisions I Moderators: Nick Curzen, Adnan Kastrati Discussants: Dimitrios Alexopoulos, Laurent Bonello, Efrain Gaxiola, Hyeon-Cheol Gwon, Michelle O Donoghue, Dirk Sibbing, Jean-François Tanguay 1:47 pm - P2Y12 Inhibitors: New Insights into Absolute and Relative PK and PD Responses Laurent Bonello 1:57 pm - P2Y12 Inhibitors: Specific Agents for Specific Patient Cohorts? (STEMI, Diabetes, CKD, Prior Stroke, Etc) Dirk Sibbing 2:07 pm - Genotyping and Platelet Function Testing: Too Early for Clinical Use or Consider in Specific Circumstances? Michelle O Donoghue 2:17 pm - When Triple Therapy Is Needed: Warfarin, Dabigatran, Rivaroxaban, and Cilostazol Considerations Harvey D. White 2:27 pm - When Surgery Is Needed: Bridging Strategies Today and Tomorrow Matthew J. Price 2:37 pm - Discussion with Q&A Session VII. Antiplatelet Therapy Decisions II: DAPT Duration Moderators: Mitchell W. Krucoff, Marco Valgimigli Discussants: Myeong-Ki Hong, Ioannis Iakovou, Takeshi Kimura, Duane S. Pinto, Peter Wenaweser, Wojciech Wojakowski 2:52 pm - Rationale and Data for Different DAPT Durations: Three to 30 Months (or Longer) David E. Kandzari 3:02 pm - Do Patient and Stent Platform Specific Variables Matter (eg, ACS vs. Stable CAD, First- vs. Second-Generation DES)? Elvin Kedhi 3:12 pm - A Preview to OPTIMIZE Fausto Feres 3:17 pm - DAPT Trial Update Laura Mauri 3:22 pm - ISAR-SAFE Update Adnan Kastrati 3:27 pm - Discussion with Q&A Session VIII. Controversies in Stenting: Two Sides to Every Story Moderators: Gregg W. Stone, Stephan Windecker Discussants: Joost Daemen, Frederick Feit, Philippe Garot, Lisette Okkels Jensen, Guy LeClerc, John A. Ormiston, Manesh R. Patel, Sigmund Silber monday - October 22,

66 Monday, October 22 3:38 pm - DES vs. BMS in STEMI: Why Is This Such a Difficult Decision? Giuseppe De Luca 3:48 pm - Discussion with Q&A 3:53 pm - Should the Presence of Diabetes Affect Decisions on PCI vs. CABG, and Which DES to Choose? Duk-Woo Park 4:03 pm - Discussion with Q&A 4:08 pm - Does CABG Convey a Survival Advantage Compared to PCI in Complex Patients and Lesions (and If So, Why)? Patrick W. Serruys 4:18 pm - Discussion with Q&A 4:23 pm - Should the AUC Determine How We Select Patients for PCI? Paul S. Teirstein 4:33 pm - Discussion with Q&A 4:38 pm - What Definition Should Be Used to Define Periprocedural MI in Clinical Trials and Practice? Gregg W. Stone 4:48 pm - Relative Frequency and Implication of Periprocedural vs. Spontaneous MI Sripal Bangalore 4:58 pm - Should Interventionalists Even Assess Post-PCI Biomarkers (CKMB, Troponins, or ECGs)? Allan S. Jaffe 5:08 pm - Discussion with Q&A 5:18 pm - Longitudinal Stent Deformation One Year Later: How Important an Issue Is This? Gregg W. Stone 5:28 pm - Discussion with Q&A 5:33 pm - Complete vs. Incomplete Revascularization: Impact on Outcomes and Implications for Strategy Giora Weisz 5:43 pm - Discussion with Q&A 5:48 pm - OK, PCI May Be Performed at Low Volume Centers with No On-site Surgery, but Are There Quality and Cost Advantages to Centralizing Care? James B. Hermiller Jr 5:58 pm - Discussion with Q&A 6:03 pm - Adjourn The Valvular Heart Disease Summit (Part 1): Aortic Valve Therapies 8:00 am-6:05 pm Hall A-Structural and Endovascular Theater Session I. Changing Perspectives in Aortic Stenosis: Epidemiology, Diagnosis, and Treatment Moderators: Blase A. Carabello, Maurice E. Sarano Discussants: Robert A. Guyton, Jan Kovac, D. Craig Miller, Friedrich W. Mohr, Vuyisile T. Nkomo, Patrick T. O Gara, Allan Schwartz, Alec S. Vahanian, Neil J. Weissman 8:00 am - The Epidemiology of Valvular Aortic Stenosis in the 21st Century Vuyisile T. Nkomo 8:07 am - Demographics and Echocardiography of Aortic Stenosis in the Modern Era: Insights from the PARTNER Trial Neil J. Weissman 8:14 am - Discussion 8:17 am - Contemporary Surgical Outcomes in Normal and High-Risk Patients with Aortic Stenosis Vinod H. Thourani 8:24 am - Appropriate Use of Balloon Aortic Valvuloplasty in Aortic Stenosis Patients Helene Eltchaninoff 8:32 am - Discussion 8:35 am - Aortic Stenosis Diagnostic and Therapeutic Clinical Pearls: A Selective View from the Guidelines (and Beyond): What Is Known! Blase A. Carabello 8:45 am - Discussion 8:47 am - My Five Most Vexing Clinical Management Dilemmas in Aortic Stenosis Patients: What Is Not Known! Allan Schwartz 8:57 am - Discussion Session II. The TAVR Explosion: Status Update of a Breakthrough Medical Technology Moderators: Martin B. Leon, Michael J. Mack Discussants: David H. Adams, Henning Rud Andersen, Peter C. Block, Stephen J.D. Brecker, Alain G. Cribier, Raimund A. Erbel, Eberhard Grube, Axel Linke, Nicolo Piazza, E. Murat Tuzcu 8:59 am - TAVR Use Patterns on the European Continent: Growth, Penetration, and Reimbursement Nicolo Piazza 9:07 am - Discussion TAVR Reflections: Observations from the Past Decade and Predictions for the Next Decade 9:09 am - Pioneer and Interventional Perspectives Alain G. Cribier 9:18 am - World Thought Leader and Surgical Perspectives Friedrich W. Mohr 9:27 am - Discussion 9:31 am - The Heart Team Management Approach in Valvular Heart Disease: Components and Value Proposition - A Sustainable Model for the Future? A. Pieter Kappetein 9:39 am - Discussion TAVR 2012: The Year in Review 9:41 am - Technology and Procedural Changes Eberhard Grube 9:51 am - Clinical Outcomes and Complications Martin B. Leon 10:01 am - Discussion Session III. Patient Selection Considerations and Procedural Planning for TAVR Moderators: Michael J. Mack, Jeffrey J. Popma Discussants: Nirat Beohar, Haim Danenberg, Philip Green, Rebecca Tung Hahn, Rudiger Lange, Jonathon A. Leipsic, Scott Lim, Francesco Maisano, Ganesh Manoharan, Neil E. Moat, Martyn R. Thomas, John G. Webb 10:07 am - The Art and Science of Risk Stratification in Aortic Stenosis: Updates on Risk Scores, Futility, and Other Imponderables Michael J. Mack 10:15 am - The Importance of Frailty Assessments in TAVR Patient Selection: Phenotype Description, Measurement Tools, and Impact on Clinical Outcomes Philip Green 10:23 am - Discussion Perspectives on Patient Selection for TAVR in :26 am - Intentional Risk Drift vs. Refinement in Risk Assessment: Data from SOURCE and Personal Experiences Martyn R. Thomas 10:33 am - Case Selection Caveats from the US CoreValve Pivotal Clinical Trial Jeffrey J. Popma 64

67 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics 10:40 am - My Criteria for Selecting Transapical TAVR (vs. Transfemoral TAVR or Open Surgery) Rudiger Lange 10:47 am - Nuggets on Patient Selection After > 1,000 TAVR Cases (Performed and/or Proctored): Balloon-Expandable TAVR John G. Webb 10:52 am - Nuggets on Patient Selection After > 1,000 TAVR Cases (Performed and/or Proctored): Self-Expanding TAVR Ganesh Manoharan 10:57 am - Discussion 11:03 am - The Essential Echocardiographic Screening Examination for TAVR (Including Annulus Measurements) Rebecca Tung Hahn 11:11 am - The Essential Multi-Slice CT Screening Examination for TAVR (Including Annulus Measurements and Vascular Assessments) Jonathon A. Leipsic 11:19 am - Discussion A LIVE MultiDisciplinary Heart Team Case Presentation for Possible TAVR Moderators: Neil E. Moat, Martyn R. Thomas 11:22 am - Presentation Isaac George 11:27 am - Discussion Session IV. Case Management Conundrums in Aortic Stenosis (with Case Examples): The Patient with... Moderators: Patrick T. O Gara, Alec S. Vahanian Discussants: Blase A. Carabello, Ulrich J. Gerckens, James B. Hermiller Jr, Howard C. Herrmann, David J. Hildick-Smith, Rudiger Lange, Philippe Pibarot, Simon Redwood, Allan Schwartz, Lars G. Svensson, Vinod H. Thourani, John G. Webb 11:34 am - Asymptomatic Severe Aortic Stenosis: Use of Exercise Testing and Watchful Waiting vs. Early Valve Replacement Blase A. Carabello 11:41 am - Discussion 11:43 am - Severe COPD and Aortic Stenosis: Screening Evaluations and Management Considerations Vinod H. Thourani 11:50 am - Discussion 11:52 am - Decreased LV Function and Aortic Stenosis: Assessment and Treatment Preferences Lars G. Svensson 11:59 am - Discussion 12:01 pm - Concomitant CAD and Aortic Stenosis: Implications and Revascularization Strategies David J. Hildick-Smith 12:08 pm - Discussion 12:10 pm - Moderate or Severe Mitral Regurgitation and Aortic Stenosis: Surgery or TAVR? John G. Webb 12:17 pm - Discussion Low Flow-Low Gradient Aortic Stenosis With and Without Reduced LV Function 12:19 pm - Echocardiographic Features and Clinical Implications Philippe Pibarot 12:26 pm - Therapy Considerations: When to Choose TAVR or Surgery Howard C. Herrmann 12:33 pm - Discussion Session V. TAVR Evidence-Based Medicine Corner I: Updates from PARTNER and Other Important Clinical Trials Moderators: D. Craig Miller, E. Murat Tuzcu Discussants: Todd M. Dewey, Gregory P. Fontana, Martine Gilard, Stuart J. Head, Ajay J. Kirtane, Axel Linke, Ian T. Meredith, Anna Sonia Petronio, Stefan Sack 12:37 pm - The VARC 2 Consensus Document: Meaningful Refinements to Improve TAVR Clinical Research Stuart J. Head 12:45 pm - Discussion PARTNER Perspectives and New Data 12:47 pm - The Influence of Gender on Clinical Outcomes in the PARTNER Trial Ajay J. Kirtane 12:54 pm - Lessons from the Quality-of-Life Studies in Inoperable and High-Risk Patients David J. Cohen 1:01 pm - New Data from PARTNER Continued Access (Nonrandomized): Transapical Outcomes After TAVR Todd M. Dewey 1:08 pm - New Data from the PARTNER Continued Access (Nonrandomized): Transfemoral Outcomes After TAVR Susheel Kodali 1:15 pm - Early Insights on Cost-effectiveness After TAVR Matthew R. Reynolds 1:22 pm - Discussion 1:28 pm - STACCATO Revisited: Reflections and Take-home Messages Leif Thuesen 1:34 pm - Discussion Brief Clinical Updates from the Important Registries 1:36 pm - The SOURCE Multicenter EU Registries (Including XT) Martyn R. Thomas 1:41 pm - The PREVAIL XT (TF and TA) Registries Stefan Sack 1:46 pm - The FRANCE 2 Registry Martine Gilard 1:51 pm - The ADVANCE TAVR Registry Axel Linke 1:56 pm - The Canadian TAVR Registry Josep Rodes-Cabau 2:01 pm - The United Kingdom TAVR Registry Neil E. Moat 2:06 pm - The Italian TAVR Registry Anna Sonia Petronio 2:11 pm - The Australia-New Zealand TAVR Registry Ian T. Meredith 2:16 pm - Featured Lecture: The German Aortic Valve Therapy Registry (GARY): Comparison of Surgery vs. TAVR and Introduction to the New AKL TAVR Risk Score Hans R. Figulla 2:26 pm - Discussion 2:36 pm - The New Transcatheter Valve Therapy US Registry: Concept, Status Update, and Future Possibilities John D. Carroll 2:44 pm - Discussion Session VI. Evidence-Based Medicine Corner II: Focus on TAVR Complications Moderators: Josep Rodes-Cabau, Martyn R. Thomas Discussants: Raimund A. Erbel, Philippe Généreux, Rebecca Tung Hahn, Samir R. Kapadia, Susheel Kodali, Karl-Heinz Kuck, Raj Makkar, D. Craig Miller, Georg Nickenig, Nicolo Piazza, Jeffrey J. Popma 2:46 pm - An Overview of TAVR Complications from a Meta-analysis Using VARC Definitions Philippe Généreux 2:54 pm - Discussion monday - October 22,

68 Monday, October Is Paravalvular Regurgitation After TAVR the Next Big Thing? 2:56 pm - Paravalvular Regurgitation as a Strong Predictor of Post-TAVR Mortality Susheel Kodali 3:03 pm - 3-D Annulus Sizing (Using MSCT or 3-D Echo) Is Now the Gold Standard and Helps to Reduce Paravalvular Regurgitation After TAVR Hasan Jilaihawi Post-Dilation After TAVR... 3:10 pm - Reduces Paravalvular Regurgitation Benoit Daneault 3:15 pm - But Also May Increase Stroke Josep Rodes-Cabau 3:20 pm - And Also Should Be Based on Hemodynamic Assessments: The Dimensionless AR Index Georg Nickenig 3:25 pm - Discussion TAVR Stroke Controversy Revisited 3:31 pm - Stroke Risk After TAVR: Results from a Large Meta-analysis Raimund A. Erbel 3:38 pm - New-Onset Atrial Fibrillation After TAVR: More Frequent Than Reported and a Possible Predictor of Stroke Josep Rodes-Cabau 3:45 pm - Bottom Line: What Is the Relative Importance of Stroke Risk After TAVR Compared to Surgery? Samir R. Kapadia 3:52 pm - Discussion Reemphasizing the Clinical Impact of Vascular Complications? 3:58 pm - Frequency, Predictors, and Consequences of Major Vascular Complications After TAVR Philippe Généreux 4:05 pm - Improved Patient Screening, Meticulous Access and Closure Techniques, and Lower Profile Catheter Systems Can Reduce Major Vascular Complications to <5%: The Vancouver Experience John G. Webb 4:12 pm - Discussion More on the Importance of TAVR Associated Conduction Disturbances 4:16 pm - New Pacemakers After TAVR: Frequency, Predictors, Clinical Outcomes, and Guidelines on When to Treat Jeffrey J. Popma 4:23 pm - New Left Bundle Branch Block Is an Independent Predictor of Mortality After TAVR Patrick Houthuizen 4:30 pm - Discussion Session VII. Procedural Controversies and New Clinical Indications Moderators: John G. Webb, Mathew Williams Discussants: Vasilis Babaliaros, Bruce Bowers, Danny Dvir, Helene Eltchaninoff, Rebecca Tung Hahn, Jean-Claude Laborde, Rudiger Lange, Anna Sonia Petronio, Augusto D. Pichard, Michael J. Reardon, Hendrik Treede TAVR Procedural Considerations 4:34 pm - The Case for Investing in a Hybrid Cath Lab/OR for TAVR Procedures Mathew Williams 4:40 pm - The Case for Minimalist TAVR: Cath Lab Setting, Local Anesthesia, and Only Fluoroscopic Guidance (No TEE) Helene Eltchaninoff 4:46 pm - The Case for Transesophageal Echo Guidance During TAVR Rebecca Tung Hahn 4:52 pm - Discussion Debate: TAVR Alternative Access Possibilities 4:56 pm - Transapical (Although Much Maligned) Remains a Viable TAVR Access Alternative! Hendrik Treede 5:04 pm - Direct Aortic Access Is Easier, Safer, and Should Be the Preferred Access Alternative! Michael J. Reardon 5:12 pm - When Do I Prefer Transsubclavian/ Axillary Alternative Access for TAVR? Jean-Claude Laborde 5:17 pm - When Do I Prefer Transcarotid Alternative Access for TAVR? Vasilis Babaliaros 5:22 pm - Discussion New TAVR Clinical Indications? Bioprosthetic Valve failure 5:26 pm - Updates from the Worldwide Valve-in-Valve TAVR Registry Danny Dvir 5:34 pm - Clinical Pearls from Experienced Valve-in-Valve Operators: Balloon Expandable TAVR for Aortic and Mitral Valve-in-Valve John G. Webb 5:40 pm - Clinical Pearls from Experienced Valve-in-Valve Operators: Self-Expanding TAVR for Aortic Valve-in-Valve Jean-Claude Laborde 5:46 pm - Discussion New TAVR Clinical Indications? Moderate Risk Patients 5:52 pm - Update from the Randomized PARTNER 2A Trial Martin B. Leon 5:57 pm - Update from the Randomized SURTAVI Trial Patrick W. Serruys 6:02 pm - Discussion 6:05 pm - Adjourn PFO and ASD Closure: Evolving Indications, Patient Selection, Devices, and Techniques 1:00 pm-6:00 pm Room B Session I. PFO and Stroke Prevention Moderators: Ziyad M. Hijazi, Robert J. Sommer Discussants: Bray Patrick-Lake, Mark Reisman, John F. Rhodes, David E. Thaler, Brian K. Whisenant 1:00 pm - Cryptogenic Stroke vs. PFO Stroke? Neurology Perspectives David E. Thaler 1:15 pm - CLOSURE 1: Failure Analysis Mark Reisman 1:30 pm - RESPECT: Late Breaking Trial Preview John D. Carroll 1:40 pm - PC Trial: Late Breaking Trial Preview Stephan Windecker 1:50 pm - REDUCE Trial Update John F. Rhodes 2:00 pm - Discussion with Q&A Session II. PFO, Migraine, and Moving Forward Moderators: Bray Patrick-Lake, Mark Reisman Discussants: Bernhard Meier, Horst Sievert, Robert J. Sommer, Jonathan M. Tobis 2:30 pm - PFO Closure for Migraine: Predictors of Clinical Improvement Following PFO Closure Brian K. Whisenant 2:45 pm - MIST Trial: Failure Analysis Robert J. Sommer 3:00 pm - PREMIUM Trial Update Jonathan M. Tobis 3:15 pm - AGA European Registry Results Bernhard Meier 3:30 pm - Making PFO Closure the Lowest Risk Interventional Procedure: Devices and Techniques Horst Sievert 3:45 pm - Discussion with Q&A

69 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics Session III. ASD Transcatheter Closure: Safety Dominates Moderators: Stephen J.D. Brecker, John F. Rhodes Discussants: John D. Carroll, Ted E. Feldman, Ziyad M. Hijazi, Horst Sievert 4:00 pm - ASD Closure: Current Techniques, Avoiding Erosion, and the Role of Surgery Ziyad M. Hijazi 4:15 pm - ASD Closure: European Perspectives Horst Sievert Debate: Should ASD Closure Only be Done in SHD/CHD Centers of Excellence? 4:27 pm - No! John D. Carroll 4:37 pm - Yes! Ted E. Feldman 4:47 pm - Discussion with Q&A Session IV. Case Presentations in ASD and PFO Closure Showcasing Special Techniques, Challenges, Patient Selection, and Complications Moderators: John M. Lasala, Jonathan M. Tobis Discussants: Frank F. Ing, Paul H. Kramer, Eustaquio Maria Onorato, Igor F. Palacios, Ramon Quesada, Maarten J. Suttorp 5:00 pm - Case 1 Clifford J. Kavinsky 5:15 pm - Case 2 Jonathan M. Tobis 5:30 pm - Case 3 Horst Sievert 5:45 pm - Case 4 John F. Rhodes 6:00 pm - Adjourn Special Twilight Sessions These sessions are only CME accredited. Featured Clinical Research I 6:00 pm-8:00 pm Room C Moderators: Peter H. Stone, S. Chiu Wong Discussants: Thomas Aversano, Nicolas A.F. Chronos, Germano Di Sciascio, Jens R. Jensen, Aaron V. Kaplan, Gervasio A. Lamas 6:00 pm - Prospective, Multicenter Evaluation of the 18 Fr Direct Flow Transcatheter Aortic Valve: CE Mark Study Joachim Schofer 6:10 pm - Discussion 6:15 pm - Prospective, Multicenter Evaluation of the Portico Transcatheter Aortic Valve: Acute Results and One-Year Outcomes Ganesh Manoharan 6:25 pm - Discussion 6:30 pm - REOPEN-AMI: A Prospective, Randomized Trial of Intracoronary Adenosine and Nitroprusside in Patients with ST- Segment Elevation Myocardial Infarction Niccoli Giampaolo 6:40 pm - Discussion 6:45 pm - A Prospective, Randomized Trial of Rosuvastatin Loading Prior to PCI Josef Veselka 6:55 pm - Discussion 7:00 pm - A Prospective, Randomized Trial of N-Acetyl Cysteine and Sodium Bicarbonate in Patients with ST-Segment Elevation Myocardial Infarction Per Thayssen 7:10 pm - Discussion 7:15 pm - SUPPORT-1: A Prospective, Randomized Trial of a Lipoic Acid-Based Cytoprotectant in Patients Undergoing Elective PCI Mitchell W. Krucoff 7:25 pm - Discussion 7:30 pm - DEBATE-SFA: A Prospective, Randomized Trial of Paclitaxel Coated Balloon Angioplasty Prior to Nitinol Stenting in Patients with SFA and Popliteal Lesions Francesco Liistro 7:40 pm - Discussion 7:45 pm - STOP-IC: A Prospective, Randomized Trial of Cilostazol After Endovascular Treatment of Femoropopliteal Lesions Hiroyoshi Yokoi 7:55 pm - Discussion 8:00 pm - Adjourn Featured Clinical Research II 6:00 pm-8:00 pm Room C Moderators: Erick Schampaert, Adam J. de Belder Discussants: John A. Ambrose, Roberto Corti, Robert J. Gil, Maurizio Menichelli, Robert W. Yeh, Ralf Zahn 6:00 pm - PARADOX: A Prospective, Randomized Trial of Clopidogrel and Prasugrel in Smokers and Nonsmokers Paul A. Gurbel 6:10 pm - Discussion 6:15 pm - A Prospective, Randomized Trial of Tailored Clopidogrel Therapy vs. Prasugrel in Patients with High On-Treatment Platelet Reactivity Laurent Bonello 6:25 pm - Discussion 6:30 pm - J-DESSERT: A Prospective, Randomized Trial of Paclitaxel-Eluting vs. Sirolimus-Eluting Stents in Patients With and Without Diabetes Masato Nakamura 6:40 pm - Discussion 6:45 pm - PARIS One Year: Impact of DAPT Cessation and Nonadherence on Adverse Events Following PCI Roxana Mehran 6:55 pm - Discussion 7:00 pm - VERDICT/FIRST: Prospective, Multicenter Study Examining the Correlation Between IVUS and FFR Parameters in Intermediate Lesions Gregg W. Stone 7:10 pm - Discussion 7:15 pm - RESOLVE: A Multicenter Study Evaluating the Diagnostic Accuracy of ifr Compared to FFR Allen Jeremias 7:25 pm - Discussion 7:30 pm - PADN-1: Pulmonary Artery Denervation for the Treatment of Refractory Pulmonary Hypertension Shao Liang Chen 7:40 pm - Discussion 7:45 pm - Plasmonic Photothermal Therapy of Atherosclerotic Lesions with Silica-Gold Nanoparticles Alexander N. Kharlamov 7:55 pm - Discussion 8:00 pm - Adjourn Focus on India: Interactive Case Review and Panel Discussion 6:00 pm-8:00 pm Room D Moderators: Ajay J. Kirtane, Susheel Kodali, Manish Parikh 6:00 pm - Welcome and Introductions 6:05 pm - Submitted Case Presentations and Discussion (Coronary) Case Presenters: TBA Case Discussants: Ziad A. Ali, Usman Baber, Hitinder S. Gurm, Duane S. Pinto, Sunil V. Rao, Nirat Beohar, Varinder P. Singh monday - October 22,

70 Monday, October 22 6:50 pm - Dinner Break 7:10 pm - Submitted Case Presentations and Discussion (Coronary/Peripheral/Structural) Case Presenters: TBA Case Discussants: Somjot S. Brar, Samir R. Kapadia, Kishore J. Harjai, Prakash Krishnan, Sahil A. Parikh, Adhir Shroff 7:50 pm - Closing Remarks 8:00 pm - Adjourn Partnership Session: Approach to Complex PCI and STEMI: From Revascularization to Complication Management Sponsored by TCT Mediterranean 6:00 pm-8:00 pm Room D Moderators: Thierry Corcos, George D. Dangas, Omer Goktekin 6:00 pm - Welcome and Introduction George D. Dangas Session I. PCI vs. CABG Case Selection Moderators: Didier Carrié, George D. Dangas Discussants: Davide Capodanno, Gennaro Sardella 6:04 pm - Utility of Scoring Systems in High-Risk PCI Stratification Davide Capodanno 6:16 pm - How to Choose Between CABG and PCI in Complex CAD: A Practical Approach Gennaro Sardella 6:28 pm - Discussion with Q&A Session II. STEMI: State of the Art Moderator: Georges Ghanem Discussants: Mohammed El Deeb, Roxana Mehran 6:38 pm - STEMI Programs in the Middle East: Organization, Unique Challenges, and Results Mohammed El Deeb 6:50 pm - Choice of Antiplatelet Therapies in ACS/STEMI Roxana Mehran 7:02 pm - Discussion with Q&A Session III. Complex PCI Case Reviews Moderators: Thierry Corcos, Luigi Salemme Panel Discussants: Panayiotis Avraamides, Habib Gamra, Nicholas N. Kipshidze, Mohamed Sobhy 7:12 pm - Case 1: Complex CAD: CABG or PCI? Murat Cayli 7:22 pm - Case 2: A Complex Bifurcation: Dedicated or Provisional? Issam D. Moussa 7:32 pm - Case 3: An Unusual Complication Luigi Salemme 7:42 pm - Case 4: A Complicated STEMI Alp Burak Catakoglu 7:43 pm - Wrap-up: Take-home from Cases 8:00 pm - Adjourn Partnership Session: How to Treat Complex Coronary Lesions Sponsored by CIT in Partnership with TCT 6:00 pm-8:00 pm Room C Moderators: Run-Lin Gao, Martin B. Leon, Gregg W. Stone Discussants: Yaling Han, Paul Hsien-Li Kao, Michael Kang-Yin Lee, Shuzheng Lu, Shubin Qiao, Weimin Wang Case I. A Complex Left Main Bifurcation 6:00 pm - Case Presentation: A Complex Left Main Bifurcation Jian Liu 6:05 pm - How Would I Treat This Patient? Part 1 Yuejin Yang 6:10 pm - How Would I Treat This Patient? Part 2 Shao Liang Chen 6:15 pm - Discussion with Q&A 6:22 pm - Case Resolution Jian Liu 6:27 pm - Moderator Wrap-up Case II. A Complex Chronic Total Occlusion 6:30 pm - Case Presentation: A Complex Chronic Total Occlusion Lei Ge 6:35 pm - How Would I Treat This Patient? Part 1 Paul Hsien-Li Kao 6:40 pm - How Would I Treat This Patient? Part 2 Jiyan Chen 6:45 pm - Discussion with Q&A 6:52 pm - Case Resolution Lei Ge 6:57 pm - Moderator Wrap-up Case III. STEMI with Multivessel Disease 7:00 pm - Case Presentation: STEMI with Multivessel Disease Qi Zhang 7:05 pm - How Would I Treat This Patient? Part 1 Lefeng Wang 7:10 pm - How Would I Treat This Patient? Part 2 Hongbing Yan 7:15 pm - Discussion with Q&A 7:22 pm - Case Resolution Qi Zhang 7:27 pm - Moderator Wrap-up Case IV. Long Lesion and Small Vessel Disease 7:30 pm - Case Presentation: Long Lesion and Small Vessel Disease Jie Qian 7:35 pm - How Would I Treat This Patient? Part 1 YunDai Chen 7:40 pm - How Would I Treat This Patient? Part 2 Haichang Wang 7:45 pm - Discussion with Q&A 7:52 pm - Case Resolution Jie Qian 7:57 pm - Moderator Wrap-up 8:00 pm - Adjourn Partnership Session: Left Main and Bifurcation Stenting: Integrated Use of FFR and IVUS Sponsored by Angioplasty Summit-TCTAP in Partnership with TCT 6:00 pm-8:00 pm Room D Moderators: Gary S. Mintz, Seung-Jung Park, Gregg W. Stone Discussants: Antonio Colombo, Jean Fajadet, David E. Kandzari, Soo-Jin Kang, Young-Hak Kim, Akiko Maehara, Patrick W. Serruys 6:00 pm - Welcome and Introductory Remarks Seung-Jung Park 6:03 pm - Morphology and Distribution of Left Main and Non-Left Main Bifurcation Atherosclerosis: What s Different, and Does It Matter? Akiko Maehara 6:13 pm - Discussion with Q&A 6:16 pm - Non-Left Main Bifurcation PCI: Integrated Use of FFR and IVUS Soo-Jin Kang 6:31 pm - Left Main PCI: Integrated Use of FFR and IVUS Gary S. Mintz 6:46 pm - Discussion with Q&A 7:00 pm - Two Complex Non-Left Main Bifurcation Cases: My Solutions Jean Fajadet, David E. Kandzari 68

71 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics 7:30 pm - Two Distal Left Main Bifurcation Cases: My Solutions Seung-Jung Park 7:45 pm - Two Distal Left Main Trifurcation Cases: My Solutions Antonio Colombo 8:00 pm - Adjourn Partnership Session: Snapshot of Latin America Practice and Research Sponsored by SOLACI in Partnership with TCT 6:00 pm-8:00 pm Room D Moderator: Oscar A. Mendiz Discussants: Jorge A. Belardi, Jorge Gaspar, Juan F. Granada, Jamil Abdalla Saad Problem I. Thrombus Containing Lesions: Practical Procedural Management 6:00 pm - Case Presentation with Discussion Martinez Sepulveda 6:13 pm - Evidence-Practice Intersection: How I Approach Thrombus in My Daily Practice (and Why) Alexandre Abizaid 6:25 pm - Discussion with Q&A Problem II. End-Stage Coronary Artery Disease 6:30 pm - Case Presentation with Discussion Ariel Duran 6:43 pm - Evidence-Practice Intersection: Why We Still Believe Angiogenesis Can Be an Alternative for No-Option Patients Alberto J. Crottogini 6:55 pm - Discussion with Q&A Problem III. Left Main PCI: How It Is Approached in Latin America, and How It Should Be 7:00 pm - Case Presentation with Discussion Rogerio Sarmento-Leite 7:13 pm - Evidence-Practice Intersection: Latin American Perspective: Our Routine Daily Approach and Outcomes Jose Armando Mangione 7:25 pm - Discussion with Q&A Problem IV. Paravalvular Leak After TAVR 7:30 pm - Case Presentation with Discussion Marco A. Perin 7:43 pm - Evidence-Practice Intersection: What We Know, What We Don t, and How to Treat Martin B. Leon Partnership Session: TCT Russia Sponsored by TCT Russia in Partnership with TCT 6:00 pm-8:10 pm Room D Moderators: Bagrat Alekyan, Juan F. Granada, Gary S. Mintz Discussants: Sergey A. Abugov, Vladimir Ganyukov, William A. Gray, Barry T. Katzen, Zaza Kavteladze, Alexander Grigorievich Osiev, Alexey Protopopov 6:00 pm - Interventional Therapy of STEMI: Perspectives from the Russian Federation Database Bagrat Alekyan 6:05 pm - Case 1: PCI in STEMI Alexey Protopopov 6:13 pm - Thrombectomy Devices: Alternatives, Tips and Tricks Petr Kala 6:23 pm - Stent Selection in STEMI: Critical Review of the Data Peter C. Smits 6:33 pm - Case 2: PCI in STEMI Vladimir Ganyukov 6:41 pm - Pharmacological Decisions in STEMI Intervention Sorin J. Brener 6:51 pm - Discussion 7:01 pm - Structural Heart Disease Intervention: Perspectives from the Russian Federation Database Bagrat Alekyan 7:06 pm - Case 3: LAA Occlusion Case Alexander Grigorievich Osiev 7:14 pm - Tips and Tricks in LAA Deployment William A. Gray 7:24 pm - Case 4: Percutaneous Repair of Thoracic Aortic Aneurysms Sergey A. Abugov 7:32 pm - Tips and Tricks During TAA Repair Barry T. Katzen 7:40 pm - Case 5: Complex Peripheral Vascular Intervention Zaza Kavteladze 7:50 pm - Below the Knee Intervention: Technique, Biological Considerations, and Beyond Hans Krankenberg 8:00 pm - Discussion 8:10 pm - Adjourn Partnership Session: The Elderly Patient: Better Treatment in the United States or Europe? Sponsored by p-c-i live in Partnership with TCT 6:00 pm-8:00 pm Room C Moderators: Hans R. Figulla, Sigmund Silber 6:00 pm - Introduction Sigmund Silber Case I. An Elderly Patient with Aortic Valve Stenosis 6:05 pm - Case Presentation Wolfgang Bocksch 6:15 pm - European Perspectives Hans R. Figulla 6:20 pm - US Perspectives Martin B. Leon 6:25 pm - Discussion with Q&A Case II. An Elderly Patient with Acute Myocardial Infarction 6:30 pm - Case Presentation Bernhard Witzenbichler 6:40 pm - European Perspectives Christian Hengstenberg 6:45 pm - US Perspectives Roxana Mehran 6:50 pm - Discussion with Q&A Case III. An Elderly Patient with Mitral Regurgitation 6:55 pm - Case Presentation Joachim Schofer 7:05 pm - European Perspectives Gerhard C. Schuler 7:10 pm - US Perspectives William A. Gray 7:15 pm - Discussion with Q&A Case IV. An Elderly Patient with Stable Coronary Heart Disease 7:20 pm - Case Presentation Gerald S. Werner 7:30 pm - European Perspectives Sigmund Silber 7:35 pm - US Perspectives Martin B. Leon 7:40 pm - Discussion with Q&A 7:45 pm - Take-home Messages Harald G.W. Mudra 8:00 pm - Adjourn monday - October 22, :55 pm - Discussion with Q&A 8:00 pm - Adjourn 69

72 Which subscription is right for you? The Source for Interventional Cardiovascular News and Education

73 Breakfast Meetings Special Sessions SCAI ELM Session...72 Board Review Course with Self-Assessment for Interventional Cardiology with Concepts of Endovascular Therapy (Part 2)...72 TCT for Nurses and Technologists...73 TCT: An Integrated Course for Surgeons and Interventionalists... 74, 111 Scientific Symposia Surgical, Interventional, and Hybrid Procedures (Part 1): Coronary Intervention...74 Peer-Reviewed Research Poster Abstract Sessions...74 Challenging Case Video Presentations...98 Oral Abstract Sessions Presentation Theater Scientific Symposia Endovascular Intervention 2012 (Part 2) First-in-Human Studies: Global Regulatory and Translational Considerations Hot Topics in Cardiology: ACC.12 with TCT Highlights for the Interventional, Invasive, and General Cardiologist Identifying the High-Risk Patient and Lesion: From Vulnerable Plaque to Ischemia Interventional Heart Failure Tuesday October 23, 2012 Miami Beach Convention Center miami, FL Launching and Sustaining Your Career Left Atrial Appendage Closure: Indications, Devices, and Techniques Next-Generation DES and Bioabsorbable Scaffolds The Valvular Heart Disease Summit (Part 2): Mitral Valve Therapies Transradial Angiography and Intervention: From Basic to Advanced Evening Programs The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics

74 Tuesday, October 23 Breakfast Meetings 7:00 am-8:00 am Please see page 164 for the Breakfast Meeting schedule. Special Sessions SCAI ELM Session In Partnership with the ACC and CRF Please note this session is by invitation only. 7:00 am-1:30 pm Room B118 This session is not CME/CNE accredited. Moderators: Frank Hildner, Srihari S. Naidu, William W. O Neill Discussants: J. Dawn Abbott, Mauricio G. Cohen, George D. Dangas, Douglas E. Drachman, Cindy L. Grines, James B. Hermiller Jr, Allen Jeremias, Navin K. Kapur, Morton J. Kern, Alexandra J. Lansky, Lynn F. Peng, Duane S. Pinto, Ramon Quesada, Paul Sorajja, Gregg W. Stone, Jennifer A. Tremmel, Thomas M. Tu 7:00 am - Breakfast 7:30 am - Welcome and Introductions Srihari S. Naidu 7:45 am - ELM Presentation J. Dawn Abbott 7:55 am - Discussion 8:05 am - ELM Presentation Mauricio G. Cohen 8:15 am - Discussion 8:25 am - ELM Presentation Douglas E. Drachman 8:35 am - Discussion 8:45 am - ELM Presentation Allen Jeremias 8:55 am - Discussion 9:05 am - ELM Presentation Navin K. Kapur 9:15 am - Discussion 9:25 am - Break 9:45 am - ELM Presentation Lynn F. Peng 9:55 am - Discussion 10:05 am - ELM Presentation Duane S. Pinto 10:15 am - Discussion 10:25 am - ELM Presentation Paul Sorajja 10:35 am - Discussion 10:45 am - ELM Presentation Jennifer A. Tremmel 10:55 am - Discussion 11:05 am - ELM Presentation Thomas M. Tu 11:15 am - Discussion 11:30 am - Interventional Cardiology and the Andreas Gruentzig Society William W. O Neill 12:00 pm - History of SCAI and CCI Frank Hildner 12:30 pm - Lunch 1:30 pm - Adjourn Board Review Course with Self-Assessment for Interventional Cardiology with Concepts of Endovascular Therapy (Part 2) 8:00 am-6:00 pm Junior Ballroom C This session is only CME accredited. 8:00 am - Introduction George D. Dangas Cardiac Cath Lab Basics Moderators: Steven R. Bailey, Manish A. Parikh Discussants: Aaron D. Kugelmass, Michael J. Lim, Roxana Mehran 8:02 am - Coronary Angiography and Ventriculography: Anatomy and Anomalies Michael J. Lim 8:20 am - Discussion with Q&A 8:30 am - Chronic Kidney Disease, Contrast Agents, and Radiocontrast Nephropathy Roxana Mehran 8:45 am - Discussion with Q&A 8:50 am - Selection of Angioplasty Guiding Catheters, Wires, and Balloons Aaron D. Kugelmass 9:05 am - Discussion with Q&A 9:10 am - Angioplasty, Atherotomy, and Atherectomy: Mechanisms of Action, Results, and Current Indications Steven R. Bailey 9:30 am - Discussion with Q&A 9:40 am - Break Stents Moderators: George D. Dangas, Ajay J. Kirtane 10:00 am - Bare Metal vs. Drug-Eluting Stents: Mechanisms of Action and Comparative Effectiveness and Safety Ajay J. Kirtane 10:20 am - Discussion with Q&A 10:30 am - Drug-Eluting Stent Systems: Design Differences and Comparative Effectiveness and Safety Duane S. Pinto 10:50 am - Discussion with Q&A 11:00 am - In-Stent Restenosis: Mechanisms, Predictors, and Treatment Roxana Mehran 11:20 am - Discussion with Q&A 11:30 am - Stent Thrombosis: Mechanisms, Predictors, and Treatment George D. Dangas 11:50 am - Discussion with Q&A 12:00 pm - Lunch Break Interventional Cardiology Devices and Outcomes Moderators: Emmanouil S. Brilakis, George D. Dangas 1:00 pm - Complex Lesions: Bifurcations and CTOs David E. Kandzari 1:20 pm - Discussion with Q&A 1:30 pm - Thrombectomy and Distal Protection in Native Coronary Artery and Saphenous Vein Graft Lesions Emmanouil S. Brilakis 1:50 pm - Discussion with Q&A 2:00 pm - Multivessel Disease and Left Main Intervention: Indications and Outcomes David R. Holmes Jr 2:20 pm - Discussion with Q&A 2:30 pm - Break Special Interventional Imaging and Physiology Session Moderators: Massoud A. Leesar, Gary S. Mintz 3:00 pm - Physiologic Lesion Assessment: Key Clinical Results, Guidelines, and Case Presentations (with Integrated Q&A) Michael J. Lim 3:30 pm - Discussion with Q&A 72

75 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics 3:45 pm - Intravascular Ultrasound, Near Infrared Spectroscopy and OCT: Key Clinical Results, Guidelines, and Case Examples (with Integrated Q&A) Gary S. Mintz 4:15 pm - Discussion with Q&A Essentials of Vascular Disease Moderators: Michael R. Jaff, Jeffrey W. Olin 4:30 pm - Endovascular Rescue During Cardiac Interventions Prakash Krishnan 4:50 pm - Discussion with Q&A 5:00 pm - Essentials of Aortic and Peripheral Arterial (Upper/Lower Extremity) Diseases: Guidelines, Assessment, and Outcomes Jeffrey W. Olin 9:00 am - Pro: Prasugrel! Giuseppe Biondi Zoccai 9:12 am - Pro: Ticagrelor! David F. Kong 9:24 am - Rebuttal and Discussion The Future of Aortic Stenosis Treatment Discussants: Julie Logan, Nicolo Piazza, Lars G. Svensson 9:36 am - Didactic Overview Julie Logan 9:48 am - TAVR Will Be for All! Nicolo Piazza 10:00 am - SAVR Still the Way for Most! Lars G. Svensson 10:12 am - Rebuttal and Discussion 8:30 am - How Do You Value and Evaluate a Cardiology Practice? Anthony Long 8:48 am - Discussion with Q&A Physician and Hospital Integration Discussants: Charles L. Brown III, Glenna Friedman, Monica Losquadro 9:00 am - Creating an Incentive Structure Using Score Cards, RVUs, and Benchmarks Charles L. Brown III 9:12 am - Appropriateness Criteria: Implications for Clinical Practice Monica Losquadro 9:24 am - How to Code and Get Reimbursed: Putting the New Models into Practice Glenna Friedman Tuesday - October 23, :20 pm - Discussion with Q&A 5:30 pm - Essentials of Carotid Artery Diseases: Guidelines, Assessment, and Outcomes Jose M. Wiley 5:40 pm - Discussion with Q&A 5:45 pm - Essentials of Renal Artery Disease: Guidelines, Assessment, and Outcomes Jeffrey W. Olin 5:55 pm - Discussion with Q&A 6:00 pm - Adjourn TCT for Nurses and Technologists These sessions are only CNE accredited. Breakout Symposium I. The Great Debates 8:00 am-12:00 pm Room A Moderator: Russell A. Brandwein Use of Appropriateness Criteria Discussants: Manesh R. Patel, Janet F. Wyman 8:00 am - Didactic Overview Janet F. Wyman 8:12 am - Protagonist Manesh R. Patel 8:24 am - Antagonist Jeffrey W. Moses 8:36 am - Rebuttal and Discussion Selection of Antiplatelet Therapy in ACS: Prasugrel vs. Ticagrelor Discussants: Giuseppe Biondi Zoccai, Pilar Dolcimascolo, David F. Kong 8:48 am - Didactic Overview Pilar Dolcimascolo Femoral vs. Radial Access Discussants: Robert J. Applegate, Kenneth A. Gorski, Paul S. Teirstein 10:24 am - Didactic Overview Kenneth A. Gorski 10:36 am - Pro: Femoral! Paul S. Teirstein 10:48 am - Pro: Radial! Robert J. Applegate 11:00 am - Rebuttal and Discussion Certification Standards for Cath Lab Staff Discussants: Jeff Davis, Regina Deible, Christopher M. Nelson 11:12 am - Didactic Overview Regina Deible 11:24 am - Perspective 1 Jeff Davis 11:36 am - Perspective 2 Christopher M. Nelson 11:48 am - Rebuttal and Discussion 12:00 pm - Adjourn Breakout Symposium II. Leadership Session: Integration and Innovation 8:00 am-12:00 pm Room B Moderators: Michael Guiry, Hilary Nierenberg Compensation Models 2012: Where Are the Incentives? Discussants: Anthony Long, James M. Palazzo 8:00 am - Health Care Reform, Payment Reform, and the Implications of Accountable Care Organizations James M. Palazzo 9:36 am - Discussion with Q&A Operations Discussants: Anthony Dawson, Michael Guiry, Anthony Long, Andrew W. Proctor, Brian Sweeney 9:42 am - Reimbursement and Practice Implications for Same-Day PCI Anthony Long 10:00 am - Operational Efficiency: Finding the Hidden Opportunity Anthony Dawson 10:12 am - Supply Chain Management: Lowering Costs and Utilization Michael Guiry 10:24 am - Managing Patient Flow to Optimize Care and Outcomes Brian Sweeney 10:36 am - Leveraging IT Systems to Improve Operational Performance Andrew W. Proctor 10:48 am - Discussion with Q&A Innovation Hour Discussants: David R. Holmes Jr, Paul Keckley, Mahesh M. Uberoi, Santosh Venkatesha 11:00 am - Lessons Learned from International Health Care Systems Paul Keckley 11:12 am - Leveraging the Cloud for Telemedicine Mahesh M. Uberoi 11:24 am - Utilizing Technology to Geographically Expand Your Practice Santosh Venkatesha 11:36 am - What Does Cardiovascular Health Care Look Like in 2022? David R. Holmes Jr 11:48 am - Discussion with Q&A 12:00 pm - Adjourn 73

76 Tuesday, October 23 Scientific Symposia Surgical, Interventional, and Hybrid Procedures (Part 1): Coronary Intervention Co-sponsored by American Association for Thoracic Surgery 8:00 am-12:15 pm Junior Ballroom D This session is only CME accredited. Session I. Multivessel Disease Moderators: A. Pieter Kappetein, Paul S. Teirstein Discussants: William E. Boden, William F. Fearon, Ajay J. Kirtane, Michael J. Mack, David X. Zhao 8:00 am - PCI and CABG from Bari to Syntax: Incorporating the Data Into Practice Ajay J. Kirtane 8:12 am - When Do I Prefer CABG for MVD? The Interventionalist s Perspective Paul S. Teirstein 8:22 am - When Do I Prefer PCI for MVD? The Surgeon s Perspective A. Pieter Kappetein 8:32 am - CABG Plus PCI for MVD: The Hybrid Option David X. Zhao 8:44 am - When Should MVD Be Managed Medically? William E. Boden Debate: Current Utilization of CABG in the US 8:54 am - CABG Today Is Under-Utilized! Michael J. Mack 9:06 am - CABG Today Is Over-Utilized! William F. Fearon 9:18 am - Discussion with Q&A Session II. Left Main Disease Moderators: Raj Makkar, David Taggart Discussants: Friedrich W. Mohr, Seung-Jung Park, Gregg W. Stone Debate: Is PCI the Preferred Option for patients with Left Main Disease? 9:30 am - Yes: Today and Definitely Tomorrow! Seung-Jung Park 9:40 am - CABG Will Always Be the Preferred Approach! Friedrich W. Mohr 9:50 am - What Will We Learn from the EXCEL Trial that We Do Not Already Know? Gregg W. Stone 10:00 am - Discussion with Q&A Session III. Hybrid Treatment of Coronary Artery Disease Moderators: Mark Vesely, David X. Zhao Discussants: Michael Argenziano, Isaac George, Jean-Michel Paradis, John D. Puskas Strategies for Hybrid Revascularization from Experienced Centers 10:10 am - Hybrid Revascularization: The Emory Approach John D. Puskas 10:18 am - Discussion 10:21 am - Hybrid Revascularization: The Columbia Approach Michael Argenziano 10:29 am - Discussion 10:32 am - Hybrid Revascularization: The Vanderbilt Approach David X. Zhao 10:40 am - Discussion 10:43 am - Hybrid Revascularization: The University of Maryland Approach Mark Vesely 10:51 am - Discussion 10:54 am - Concurrent Coronary Artery and Valvular Heart Disease 1: Hybrid PCI with Surgical Valves Isaac George 11:04 am - Concurrent Coronary Artery and Valvular Heart Disease 2: Hybrid PCI with Transcatheter Valves Jean-Michel Paradis 11:14 am - Discussion with Q&A Session IV. CAD Case Presentations: CABG, PCI, Hybrid, or Medical Therapy? Multidisciplinary Perspectives Moderators: Susheel Kodali, Mathew Williams Discussants: William E. Boden, William F. Fearon, Isaac George, A. Pieter Kappetein, Friedrich W. Mohr, John D. Puskas, Mark Vesely, Robaayah Zambahari 11:25 am - Three Cases of Increasing Clinical and Anatomic Complexity Kendra J. Grubb 12:15 pm - Adjourn Poster Abstract Sessions 8:00 am-10:00 am Hall D These sessions are only CME accredited. Antithrombin and Antiplatelet Agents TCT-720. Triple vs. Dual Antiplatelet Therapy in Patients with Acute Myocardial Infarction and Renal Insufficiency: Results from Korea Acute Myocardial Infarction Registry Sang Yup Lim et al TCT-721. P2Y12 Reactivity Units (PRU) to Predict Hyporesponsiveness to Clopidogrel in Patients with Chest Pain with Prior History of Coronary Artery Stenting in Emergency Department Rakesh K. Sharma et al TCT-722. Platelet Function Testing Predicts Bleeding In Patients Exposed To Clopidogrel Undergoing Coronary Artery Bypass Grafting Grant W. Reed et al TCT-723. Transferring from Clopidogrel Loading Dose to Prasugrel Loading Dose in Acute Coronary Syndrome Patients: High On-Treatment Platelet Reactivity Analysis of the TRIPLET Trial Jean G. Diodati et al TCT-724. Clopidogrel Loading Doses Result in Favourable Changes in Nitric Oxide (NO) Metabolism in Patients with Stable Angina Undergoing Percutaneous Coronary Intervention (PCI) Richard A. Anderson et al TCT-725. Point-of-Care Genetic Testing of Eleven CYP2C19 Single Nucleotide Polymorphisms Identifies Extensive and Reduced Metabolizers of Clopidogrel with High Accuracy in Patients With Coronary Artery Disease David Erlinge et al TCT-726. Residual Platelet Reactivity Threshold After Clopidogrel Loading Dose to Predict Long-term Clinical Outcome in Patients with Acute Coronary Syndrome: Insights from the RECLOSE2-ACS Study Renato Valenti et al TCT-727. Meta-analysis Comparing Bleeding Rates After Low vs. High Dose Clopidogrel in Patients Undergoing Percutaneous Coronary Intervention and Receiving a Glycoprotein IIb/IIIa Inhibitor Christopher M. Huff et al 74

77 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics TCT-728. Clinical Presentations, Antiplatelet Strategies, and Prognosis of Patients with Stent Thrombosis: An Observational Study of 140 Patients Ya-Ling Han et al TCT-729. Discontinuation of Long-term Clopidogrel Therapy Is Associated with Death and Myocardial Infarction After Saphenous Vein Graft Percutaneous Coronary Intervention Somjot Brar et al TCT-730. Hospitalization Costs of Acute Coronary Syndrome Patients Undergoing Percutaneous Coronary Intervention: Comparison Between Clopidogrel and Prasugrel Patients in a US Hospital Database Jay Bae et al TCT-731. Switching from Clopidogrel to Prasugrel in Patients Undergoing Coronary Stent Implantation Guido Parodi et al TCT-732. Paraoxonase 1 Gene Polymorphism Does Not Affect Clopidogrel Response Variability but Is Associated with Clinical Outcome After Percutaneous Coronary Intervention Jin Joo Park et al TCT-733. Relation of Proton Pump Inhibitor and Cytochrome P450 2C19 Polymorphisms on Pletelet Reactivity in Patients with Coronary Syndromes Zenko Nagashima et al TCT-734. Influence of Platelet Reactivity and Inflammation on Periprocedural Myonecrosis in East Asian Patients Undergoing Elective Percutaneous Coronary Intervention Young-Hoon Jeong et al TCT-735. Pharmacodynamic Effect of Adjunctive Cilostazol vs. High-Dose Clopidogrel in Acute Coronary Syndrome Patients According to the CYP2C19 Genotype (ACCEL-GENOTYPE) study Young-Hoon Jeong et al TCT-736. Markedly Reduced Platelet Inhibition with Clopidogrel Given to Patients Undergoing Therapeutic Hypothermia Post-Cardiac Arrest Rohit Moudgil et al TCT-737. Relationship Between Post- Treatment Platelet Reactivity and Ischemic and Bleeding Events at One-Year Follow-up in Acute Coronary Syndrome Patients Receiving Prasugrel Laurent Bonello et al TCT-738. Thrombocytes and IndividuaLization of Oral Antiplatelet Treatment After Percutaneous Coronary Intervention (TAILOR) Nadia Paarup Dridi et al TCT-739. Effect of Ticagrelor on the Outcomes of Patients with Prior Coronary Artery Bypass Graft Surgery: Insights from the Platelet Inhibition and Patient Outcomes (PLATO) trial Emmanouil Brilakis et al TCT-740. Clinical Impact of Extended Dual Antiplatelet Therapy After Percutaneous Coronary Interventions in the Drug-Eluting Stent Era: A Meta-analysis of Randomized Trials Salvatore Cassese et al TCT-741. Impact of Clinical Presentation on Platelet Inhibition by Ticagrelor Compared to Clopidogrel: Insights from a Single-Center Cohort of the PLATO Trial Daniel Aradi et al TCT-742. Individual and Regional Variations in Dual Antiplatelet Therapy Dose and Duration in a Large, Randomized International Trial Comparing Two Drug-Eluting Stents: Results from PROTECT Laura Mauri et al TCT-743. Platelet Function Monitoring in Patients with Acute Myocardial Infarction: Does Time Matter? Rebecca Torguson et al TCT-744. Double (360 mg) Loading Dose of Ticagrelor in Patients with ST-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention Dimitrios Alexopoulos et al TCT-745. Can Aspirin/Clopidogrel Resistance Affect the Occurrence of Intra-Stent Thrombi? Junbeom Park et al TCT-746. Physicians Response to Platelet Function Testing After Percutaneous Coronary Therapy: Does High On-Treatment Platelet Reactivity Testing Impact Antiplatelet Strategy? Gabriel Sardi et al TCT-747. Efficacy and Safety of Intensified Antiplatelet Therapy on the Basis of Platelet Reactivity Testing in Patients After Percutaneous Coronary Intervention: Systematic Review and Meta-analysis Daniel Aradi et al TCT-748. Double the Dose of Clopidogrel or Switch to Prasugrel to Antagonize Proton Pump Inhibitor Interaction Jean-Philippe Collet et al TCT-749. Heparin vs. Bivalirudin: In-Hospital and 30-Day MACE in Patients Having DES Implantation Evan Shlofmitz et al TCT-750. Can the Rate of Acute Stent Thrombosis with Bivalirudin Anticoagulation During Primary PCI in STEMI Be Reduced with Modified Pharmacologic Regimens? Andreas Baumbach et al TCT-751. Novel Oral Anticoagulants in Patients with Acute Coronary Syndromes: Meta-analysis of Randomized Controlled Trials András Komócsi et al TCT-752. Ecarin Clotting Time (ECT) More Accurately Reflects Bivalirudin Concentration Than Activated Clotting Time (ACT) in Patients Undergoing Percutaneous Coronary Intervention Using Bivalirudin Anticoagulation Ronan J. Margey et al TCT-753. Impact of Bivalirudin on Periprocedural Events in Patients Undergoing Rotational Atherectomy: A Subanalysis of the Randomized ROTAXUS Trial Mohamed Abdel-Wahab et al Aortic Valve Disease and TAVR TCT-800. Transcatheter Aortic Valve Replacement (TAVR) with a New Self- Expanding Percutaneous Heart Valve and Motorized Delivery System Ronald Binder et al TCT-801. Outcome After a TAVI Procedure with Self-Expanding Bioprothesis Using CoreValve or Accutrack Delivery Device: France 2 Registry Results Gauthier Mouillet et al TCT-802. Impact of Experience on TAVI Outcome a Propensity Matched Analysis from the PRAGMATIC Plus Initiative Nicolas M. Van Mieghem et al TCT-803. Emergency and Prophylactic Use of Miniaturized Veno-Arterial Extracorporeal Membrane Oxygenation (vaecmo) in Transcatheter Aortic Valve Implantation Oliver Husser et al TCT-804. Safety and Efficacy of 14 Fr Balloon-Expandable Sheath for Transcatheter Aortic Valve Implantation Hirotsugu Mitsuhashi et al TCT-805. Impact of Pulmonary Hypertension on Outcome After Transcatheter Aortic Valve Implantation Alexander Lauten et al Tuesday - October 23,

78 Tuesday, October 23 TCT-806. Long-term Outcomes from the CoreValve Transcatheter Aortic Valve Australia-New Zealand Study Ian T. Meredith et al TCT-807. Self-Expandable Transcatheter Aortic Valve Implantation for Aortic Stenosis After Mitral Valve Surgery Giuseppe Bruschi et al TCT-808. Expansion Geometry of the Edwards Sapien XT Aortic Valve Following a MSCT-Guided Oversizing Approach Alexander W. Leber et al TCT-809. Impact of New Conduction Defect After TAVI on Left Ventricular Function at One-Year Follow-up Rainer Hoffmann et al TCT-810. Assessment of Doubtful Aortic Stenosis by Measuring Simultaneous Transaortic Pressure: A Pilot Study with Fractional Flow Reserve Guidewire Romain Chopard et al TCT-811. Hospitalisation Cost of TAVI in Belgium: An Analysis in One University Hospital Johan Bosmans et al TCT-812. Thirty-day Outcome of the 18-Fr Direct Flow Medical Valve in Patients with Severe Aortic Stenosis: Results from the DISCOVER Trial Joachim Schofer et al TCT-813. Long-term Performance of a Transfemorally Implantable Nonmetallic, Retrievable, and Repositionable Aortic Valve in Patients with Severe Aortic Stenosis Four-Year Follow-up of the 22-Fr Direct Flow Medical Valve Klaudija Bijuklic et al TCT-814. Health Related Quality of Life Following Transcatheter Aortic Valve Implantation: Results from the CoreValve ADVANCE Study Johan Bosmans et al TCT-815. Prognostic Role of Serum Cardiac Biomarker Elevation After Transcatheter Aortic Valve Replacement Israel Barbash et al TCT-816. Anticipated Utilization of Transcatheter Aortic Valve Replacement Reflects Cautious Optimism of the US Interventional Cardiology Community Akshar Y. Patel et al TCT-817. Transcatheter Aortic Valve Replacement with a New Balloon Expandable Percutaneous Heart Valve Ronald Binder et al TCT-818. Balloon Aortic Valvuloplasty In Severe Aortic Stenosis And Prevention of Restenosis in Elderly Matjaz Bunc et al TCT-819. Effect of Transfemoral Aortic Valve Implantation on Plasma Brain Natriuretic Peptide Levels and Its Predictive Value for 30-Day and One-Year Survival Karim El Chilali et al TCT-820. Transcatheter Aortic Valve Implantation (TAVI) In Patients Unsuitable for a Transfemoral Approach: A Comparison Between Transapical and Transaxillary Approaches Jason Leung Kwai Chan et al TCT-821. Initial Experience with Transfemoral Implantation of the Prosthesis Edwards Sapien XT Without Previous Valvuloplasty in Patients with Severe Aortic Stenosis Eulogio J. Garcia et al TCT-822. Computed Tomography Evaluation Prior to CoreValve Implantation Predicts Postprocedural Aortic Regurgitation Sabine Bleiziffer et al TCT-823. In-Vitro Assessment of the Influence of Oval Annuli on the Hydrodynamic Function of Percutaneous Heart Valve Prostheses Maximilian Kuetting et al TCT-824. The Impact of Creation of a Transcatheter Aortic Valve Program on Surgical Aortic Valve Replacement (SAVR) Volume and Outcomes: A Single-Center Experience Firas E. Zahr et al TCT-825. Antegrade-Transseptal, Retrograde, or Trasapical Access to the Ascending Aorta Hemodynamic: A Comparision Study in a Porcine Model Sabine Wipper et al TCT-826. Does Diabetic Status Impact the Outcome of TAVR Procedures? Insights from the France2 Registry Eric Van Belle et al TCT-827. Interaction Between Perivalvular Aortic Regurgitation and Delivery Approach: Impact on Clinical Outcome After TAVI: Insights from the France 2 Registry Eric Van Belle et al TCT-828. Standardized Segmentation of Aortic Annulus Across Multimodalities Imaging Techniques: Location of Annulus Calcification Predicts Periprosthetical Leaks Post TAVI Vlad Ciobotaru et al TCT-829. Invasive Systemic Arterial Hemodynamics in Low Gradient Severe Aortic Stenosis with Preserved Ejection Fraction Mackram Eleid et al TCT-830. Immediate and Delayed Effects of Stent Crimping on Pericardial Leaflets of Transcatheter Valves Arash Kheradvar et al TCT-831. Transcatheter Aortic Valve Implantation in Patients of Small Body Size Thierry Lefèvre et al TCT-832. Epidemiology of Severe Aortic Stenosis in the Elderly: A Systematic Review and Meta-analysis of Published Prevalence Estimates Ruben L. J. Osnabrugge et al TCT-833. Is Transcatheter Aortic Valve Implantation a Cost-effective Treatment in Patients Who Are Ineligible for Surgical Aortic Valve Replacement? James Eaton et al TCT-834. Qualitative Assessment on TAVI Utilization: A European Perspective Rachele Busca et al TCT-835. Permanent Pacemaker Implantation After Transcatheter Aortic Valve Implantation: Is There Any Impact on Survival? Thierry Lefèvre et al TCT-836. Prediction of Paravalvular Leaks After Transcatheter Aortic Valve Implantation by Valvular or Annular Calcification Gudrun Feuchtner et al TCT-837. Effectiveness and Possible Complications of Post-Dilatation in Patients with Residual Significant Aortic Regurgitation Following Valve Implantation Using Both Edwards and CoreValve Systems: A Single-Center Study Ahmed Rezq et al TCT-838. Using Inferior Epigastric Artery for Vascular Access Optimization During Transcatheter Aortic Valve Implantation Manolis Vavuranakis et al TCT-839. Early Changes of Left Ventricle Deformation Indices After Transcatheter Aortic Valve Implantation: A Speckle Tracking Echocardiographic Study Manolis Vavuranakis et al TCT-840. Mortality Risk for Transcatheter Aortic Valve Implementation Patients Eventually Approaches General Population: Innovative Time Series Analysis of Outcomes Hala Sharaf et al TCT-841. One-Year Outcomes Following Transcatheter Aortic Valve Implantation vs. Surgical Aortic Valve Replacement in Patients Over 75 Years: The Elderly Pilot Study Alaide Chieffo et al 76

79 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics TCT-842. Embolic Particles Show Surprising Size Dependent Predilection for Cerebral vs. Peripheral Arteries: Results from Computational Fluid Dynamic Modeling Shawn C. Shadden et al TCT-843. Transcatheter Aortic Valve Implantation with Edwards SAPIEN XT vs. Medtronic CorEvalve REvalving System with AccuTrak: The SAPERE Pilot Study Gill L. Buchanan et al TCT-844. Clinical Outcome of Patients with Low-Flow, Low-Gradient Aortic Stenosis After Transcatheter Aortic Valve Implantation Jury Schewel et al TCT-845. Clinical Outcome of Patients with Paradoxical Low-Flow, Low-Gradient Aortic Stenosis After Transcatheter Aortic Valve Implantation Jury Schewel et al TCT-846. Acute Assessment of Transcatheter Aortic Valve Performance After Implantation into Degenerated Aortic Surgical Bioprostheses Ulrich Schäfer et al TCT-847. Adequate Choice of the Post Dilatation Balloon Size in Patients Undergoing TAVI Based on the CT Scan Analysis Ahmed Rezq et al TCT-848. Clinical Impact of Paravalvular Leaks on Biomarkers and Survival After Transcatheter Aortic Valve Implantation Dimitry Schewel et al TCT-849. Predictive Reliability of Logistic EuroScore II in Patients Undergoing Transcatheter Aortic Valve Implantation: Assessment and Comparison to Classic Systems of Preoperative Risk Stratification Lenard Conradi et al TCT-850. Early Clinical Outcome of Transcatheter Valve-in-Valve Implantation in the Nordic Countries Leo Ihlberg et al TCT-851. Patients Referred for Transcatheter Aortic Valve Implantation: Reasons for Rejection and Survival in a Real-world Population Kirsten Boerlage-van Dijk et al TCT-852. Successful Transfemoral Implantation of a Medtronic CoreValve in Patients with Severe Aortic Regurgitation: A Single-Centre Experience Marco Luciano Rossi et al TCT-853. Procedural Results of Direct Implantation of the Self-Expanding CoreValve Aortic Bioprosthesis Without Prior Valvuloplasty Emmanuel Chorianopoulos et al TCT-854. Prognostic Value of Preinterventional Troponin T Levels in Patients with Severe Aortic Stenosis Undergoing TAVR Emmanuel Chorianopoulos et al TCT-855. Chronic Obstructive Pulmonary Disease in Patients Undergoing Transcatheter Aortic Valve Implantation: Insights on Clinical Outcomes, Prognostic Markers, and Functional Status Changes Michael Mok et al TCT-856. Impact of Transcatheter Aortic Valve Implantation on Aortic-Mitral Valve Coupling Wendy Tsang et al TCT D Multidetector Computed Tomography Predictors of Prosthesis-Patient Mismatch in Transcatheter Aortic Valve Replacement Melanie Freeman et al TCT-858. Transapical Aortic Valve Replacement with The JenaValve: Less Pravalvular Leackage and Higher Transvalvular Gradient Alexander Lauten et al TCT-859. Transcatheter Aortic Valve Implantation with Edwards SAPIEN vs. Medtronic CoreValve Revalving System Devices: A Multicenter Collaborative Study The PRAGMATIC Initiative: Pooled Rotterdam-Milano-Toulouse in Collaboration Alaide Chieffo et al TCT-860. Does the Logistic EuroScore II Better Predict Outcomes Following Transcatheter Aortic Valve Implantation? Results from the Milan Registry Gill L. Buchanan et al TCT-861. The Effect of Inflammation on Left Ventricular Function After Trancatheter Aortic Valve Implantation Manolis Vavuranakis et al TCT-862. Flow Characteristics of the CoreValve and Potential Underestimation of Aortic Valve Cross-Sectional Area Following Transcatheter Valve Implantation Alison Duncan et al TCT-863. Severe Decline in Platelet Count in Patients Treated by Transcatheter Aortic Valve Replacement Is an Independent Correlate for Worse Clinical Outcome Danny Dvir et al TCT-864. A Comparison of the Femoral and Radial Crossover Techniques for Vascular Access Management in Transcatheter Aortic Valve Implantation: The Milan Experience Helen Curran et al TCT-865. Rotational Aortography with CT Reconstruction Can Guide Transcatheter Aortic Valve Replacement and Predict Prosthetic Regurgitation Carlos Alfonso et al TCT-866. Transcatheter Aortic Valve Implantation in Patients with Bicuspid Aortic Valve Disease: Results from the Milan Registry Gill L. Buchanan et al TCT-867. Clinical Impact of Persistent Left Bundle Branch Block After CoreValve Revalving System Implantation: Insight from a Multicenter Italian Registry Luca Testa et al TCT-868. Incidence, Predictors, and Impact of Bleeding After Transcatheter Aortic Valve Implantation Bogdan Borz et al TCT-869. Percutaneous Clousure of Paravalvular Aortic Leak with AVP III Device, Clinical Follow-up Late Eulogio J. Garcia et al TCT-870. Frailty Assessment Tools: Impact on Short-term Outcome After TAVI Felix Woitek et al TCT-871. Leveraging Preparatory Balloon Aortic Valvuloplasty (BAV) During TAVI for Improved Valve Sizing: A Simple Way to Reduce Paravalvular Aortic Regurgitation?! Polykarpos Christos Patsalis et al TCT-872. Results of Transfemoral TAVI in Partner-Like Patients: A Comparison with Real-world Patients Fadi Al-Rashid et al TCT-873. Results of Transfemoral Aortic Valve Implantation (TF-TAVI) Performed by External Cardiologists in Collaboration with an Experienced Multidisciplinary Heart Team at a Specialized Center Philipp Kahlert et al TCT-874. Hemodynamic Assessment of Residual Paravalvular Aortic Regurgitation (PAR) After TAVI: Impact of Myocardial Supply-Demand Ratio (DPTI:SPTI) on Survival Polykarpos Christos Patsalis et al TCT-875. Frailty Is a Major Determinant of Length of Stay After Transcatheter Aortic Valve Replacement Abhijit Ghatak et al TCT-876. Decreasing B-Type Natriuretic Peptide Predicts Survival After Transcatheter Aortic Valve Replacement Peeyush Grover et al TCT-877. Historical Trends in Outcomes Following Aortic and Mitral Heart Valve Replacement Procedures: A Population- Based Study of 29,582 Medicare Patients from 1997 to 2009 Jasmine Patel et al Tuesday - October 23,

80 Tuesday, October 23 TCT-878. Transaortic Valve Implantation (TAVI) Normalises Subendocardial Function in Patients with Severe Aortic Stenosis Alison Duncan et al TCT-879. SIMPLIPHieDE (Single-Center IMPella LVAD Supported PCI in High-Risk Group of Patients: Detroit Medical Center Experience) Balloon Aortic Valvuloplasty: Technique and Clinical Outcomes Haroon Faraz et al TCT-880. CT-Angiography vs. Angiography in Iliacofemoral Tract Diameter Assessment: The Imaging Modality Can Be Determinative in Choice of Approach for Transcatheter Aortic Valve Implantation Esther M.A. Wiegerinck et al TCT-881. Embolic Cerebral Insults and Microbleeds After Percutaneous Aortic Valve Replacement and Surgical Aortic Valve Replacement Detected by Magnetic Resonance Imaging Stephan Ensminger et al TCT-882. Has Balloon Aortic Valvuloplasty for Severe Aortic Stenosis Improved Outcomes in the Transcatheter Aortic Valve Replacement Era? Itsik Ben-Dor et al TCT-883. Calcification Displacement and Tissue Deformation Due to Transcatheter Aortic Valve Replacement: An Image-Based Analysis Method Bart Bosmans et al TCT-884. Frequency and Causes of Stroke During or After Transcatheter Aortic Valve Implantation Rutger-Jan Nuis et al TCT-885. Transcatheter Aortic Valve Implantation with Medtronic CoreValve vs. Medtronic CoreValve with Accutrak Delivery System Gill L. Buchanan et al TCT-886. Predictors of Vascular Complications in Patients Undergoing Balloon Aortic Valvuloplasty Roxana Mehran et al TCT-887. TAVR: Three-Year Results of Transapical vs. Transfemoral Approach in a Real-world Population of 1,000 Patients with Severe Aortic Stenosis G. Schymik et al TCT-888. Patients with Aortic Stenosis Referred for Transcatheter Aortic Valve Implantation: Treatment Decision, In-Hospital Outcome and Determinants of Survival Rutger-Jan Nuis et al TCT-889. Sex-Related Clinical Characteristics and Outcome Before and After Transcatheter Aortic Valve Implantation Manolis Vavuranakis et al TCT-890. Gender Differences in Patients with Severe Aortic Stenosis Undergoing Transcatheter Aortic Valve Implantation Stefan Stortecky et al TCT-891. Outcomes of Transcatheter Aortic Valve Replacement vs. Standard Therapy Among Women Deemed Too High Risk for Surgery in the PARTNER Trial Susheel Kodali et al TCT-892. Predictors of Futility with Transcutaneous Aortic Valve Replacement Therapy (TAVR): An Analysis from the PARTNER Randomized Trial Nirat Beohar et al TCT-893. Does Left Ventricular Hypertrophy Affect Outcomes in Patients Undergoing Transcatheter Aortic Valve Replacement? Nimesh Desai et al TCT-894. Impact of Transcatheter Aortic Valve Implantation on Mitral Regurgitation: Insights from a Multicenter Study Konstantinos Toutouzas et al TCT-895. Prediction of Implanted TAVI Prosthetic Size by 3-D TEE Assessment Ulrich Hink et al TCT-897. Variation in Use, Costs, and Hospital Profitability for Aortic Valve Replacement Procedures: A Descriptive Analysis Mary Ann Clark et al TCT-898. Incidence and Impact of Acquired Thrombocytopenia on Bleeding Events and Mortality After Transcatheter Aortic Valve Replacement (TAVR) Philippe Généreux et al TCT-899. Risk of Respiratory Failure After Minimally Invasive Transapical Aortic Valve Implantation Martin Haensig et al TCT-900. High-Degree Atrioventricular Block and Need for Permanent Pacemaker Implantation After Transcatheter and Surgical Aortic Valve Replacement Irene Franzoni et al TCT-901. Improved Mitral Valve Performance After Transapical Aortic Valve Implantation Martin Haensig et al TCT-902. Report from the Swedish TAVI Register: Comparison of Two Valve Types Jan Harnek et al TCT-903. Incidence and Predictors of Left Bundle Branch Block After Transcatheter Aortic Valve Implantation Irene Franzoni et al TCT-904. Catheter Laboratory Predictors of Postprocedure Paraprosthetic Aortic Regurgitation Following Self-Expanding Medtronic CoreValve Implantation: A Multicentre Registry Analysis Omar Ali et al TCT-905. Direct Aortic Implantation of a Self-Expandable Aortic Bioprosthesis: The European Experience Giuseppe Bruschi et al TCT-906. Towards Simulation-Based Preoperative Planning of Transcatheter Aortic Valve Replacement Carl J. Schultz et al TCT-907. Transcatheter Aortic Valve Replacement for Pure Severe Native Valve Aortic Regurgitation David A. Roy et al TCT-908. Gender-Related Differences in Baseline Characteristics and Clinical Outcome of Transcatheter Aortic Valve Implantation Mohamed Abdel-Wahab et al TCT-909. Minimizing Radiation Exposure during Transcatheter Aortic Valve Replacement (TAVR) Procedures Adesh Ramsewak et al TCT-910. Patient-Specific Computational Modeling of Transcatheter Aortic Valve Implantation Elaine Tseng et al Bifurcation Stenting TCT-675. Prolonged Ischemia, Detected by Intracoronary Electrocardiography, After Coronary Bifurcation Stenting Predicts Adverse Events During Mid-term Follow-up Alexander Alexandrov et al TCT-676. The Glider Balloon: A Useful Device for the Treatment of Bifurcation Lesions Carlo Briguori et al TCT-677. Use of Troponin to Diagnose Periprocedural Myocardial Infarction: Effect on Composite Endpoints in the British Bifurcation Coronary Study (BBC ONE) James A. Cockburn et al TCT-678. Tryton-Xience for the Treatment of Complex Coronary Bifurcation Lesions: A Single-Center Consecutive Series Daniela Trabattoni et al TCT-679. Coronary bifurcation Angle from 3-D Predicts Clinical Outcomes After Stenting Bifurcation Lesions Shao Liang Chen et al 78

81 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics TCT-680. Long-term Outcome of Patients with Bifurcated Lesions Randomized to Sirolimus of Everolimus Eluting Stent: The Sea-Corp BC Study Francesco Burzotta et al TCT-681. Long-term Outcomes of Simple and Complex Coronary Bifurcation Lesions (CBL) Treated with Drug-Eluting Stents Leonard Ngunga et al TCT-682. Long-term Outcomes of Two Stent Technique for the Treatment of Complex Coronary Bifurcations in the Drug-Eluting Stent Era: A Comparison of Three Contemporary Strategies Leonard Ngunga et al TCT-683. The Impact of Side Branch Predilatation on Procedural and Long-term Clinical Outcomes in Coronary Bifurcation Lesions Treated by Provisional Approach: Results from the COBIS (Coronary BIfurcation Stent) Registry Pil Sang Song et al TCT-684. Regular Drug Eluting Stent vs. Dedicated Bifurcation Paclitaxel-Eluting Stent (BiOSS) in Coronary Bifurcation Treatment: POLBOS (POLish Bifurcation Optimal treatment Strategy) Randomized Study Robert J. Gil et al TCT-685. Push-and-Bend Technique for Coronary Bifurcations Achim Gutersohn et al TCT-686. T-Stenting with Two Drug-Eluting Stents vs. One Drug-Eluting Stent with Side Branch PTCA: Long-Term Pathological Findings in Bifurcation Lesions Seung-Jin Oh et al TCT-687. First-in-Man (FIM) Study of Dedicated Bifurcation Sirolimus-Eluting Stent BiOSS (Bifurcation Optimization Stent System) LIM: Nine-Months Results Robert J. Gil et al TCT-688. Treatment of Bifurcation Lesions with a Drug-Eluting Stent with Biodegradable Polymer Fazilatum Nesa Malik et al TCT-689. Impact of Final Kissing Ballooning on Stent Expansion, Apposition, and Neointimal Hyperplasia in Coronary Bifurcation Lesions Treated with One-Stent Technique Joo-Yong Hahn et al TCT-690. Safety and Clinical Efficacy of Sideguard Stent for Treatment of Bifurcation Lesions: Interim Results from the European Sideguard Bifurcation Registry Study Farzin Fath-Ordoubadi et al TCT-691. The Feasibility and Safety of Balloon Dilation Over the Jailed Wire to Reopen the (Sub-)Occluded Side Branch During Provisional Stenting Li Chengxiang et al TCT-692. Impact of Treatment Strategy on Clinical Outcomes Differs Between Patients with Left Main and Those with Non-Left Main Bifurcation Lesions Young Bin Song et al Bleeding, Thrombosis, Embolization, and Other Complications TCT-546. Timing of Access Site Bleeding After Transfemoral Coronary Intervention Pranjal K. Boruah et al TCT-547. Ischemic Stroke Associated with Left Cardiac Catheterization: The Importance of Modifiable and Non-Modifiable Risks Factors Batric Popovic et al TCT-548. Long-term Follow-up After Percutaneous Coronary Intervention with Polytetrafluoroethylene-Covered SYMBIOT Stents Compared to Bare Metal Stents, With and Without FilterWire Embolic Protection, in Diseased Saphenous Vein Grafts: The STROMBOLI Trial Johan Bennett et al TCT-549. Impact of Clinical Presentation on In-Hospital Bleeding Outcomes in Percutaneous Coronary Intervention Joshua P. Loh et al TCT-550. The Impact of Upstream Anticoagulation on In-Hospital Bleeding in Patients with Acute Coronary Syndrome Undergoing Percutaneous Coronary Intervention Joshua P. Loh et al TCT-551. Prophylactic Use of Intracoronary Nicardipine in Conjunction with Distal Protection Devices During Vein Graft Intervention: Synergistic Effect of Combining Drugs and Devices Michael P. Savage et al TCT-552. The Impact of Vascular Access for In-Hospital Major Bleeding in Acute Coronary Syndrome Patients with Moderateto Very High-Bleeding Risk Keun-Ho Park et al TCT-553. One-Year Cardiovascular and Renal Outcome of Sodium Bicarbonate in Comparison with Saline for Prevention of Contrast-Induced Nephropathy After Cardiac Catheterization: A Randomized Control Trial Junichi Tazaki et al TCT-554. Postprocedure Major Bleeding Events in Patients Undergoing Percutaneous Coronary Intervention: Validation of BLEEDRS-A Simplified HAS-BLED Score Imdad Ahmed et al TCT-555. Release of Bioactive Lipids During Percutaneous Coronary, and Peripheral Arterial Interventions in Humans: Lipidomic Analysis of Distal Embolic Protection Devices Amir Ravandi et al TCT-556. The Incidence and Outcome of Devices Stuck in the Coronary Artery During Percutaneous Coronary Intervention: A Toyohashi Experience Masashi Kimura et al TCT-557. The Risk of In-Hospital Bleeding and Long-term Mortality in Patients with ST-Elevation Myocardial Infarction Treated with Primary Percutaneous Coronary Intervention H. Boden et al TCT-558. Red Cell Distribution Width as a Correlate of Post-Percutaneous Intervention Bleeds Omid Fatemi et al TCT-559. On-Treatment Platelet Reactivity Testing Before Coronary Artery Bypass Surgery: Does It Predict In-Hospital Major Bleeding? Gabriel Sardi et al TCT-560. Impact of Intraprocedural Coronary No Reflow on Two-Year Clinical Outcomes Following Percutaneous Coronary Intervention with Drug-Eluting Stents Amro Elnagar et al TCT-561. Risk Stratification and Outcomes of Patients with Prior Coronary Artery Stenting Undergoing Noncardiac Surgery Andrew L. Goodman et al TCT-562. Temporal Trends in Cost and Resource Utilization Following PCI- Associated Gastrointestinal Bleeding Vabhave Pal et al Bare Metal and Drug-Eluting Stents TCT-601. Real-world Experience of the Polymer-Free Rapamycin-Eluting YUKON- Choice Stent: Five-Year Results from a Prospective Registry Marc-Alexander Ohlow et al TCT-603. Proximal Coronary Artery Stenting: DES vs. BMS and LAD vs. the Rest Fredrik Calais et al TCT-604. Per-Lesion Interobserver Variability and Impact on Syntax Score Gerardo Nau et al Tuesday - October 23,

82 Tuesday, October 23 TCT-605. Impact of Stent Overlap on Long-term Clinical Outcomes in Patients Treated with Newer-Generation Drug-Eluting Stents Crochan J. O Sullivan et al TCT-606. Cost-effectiveness of Everolimus- Eluting Stents Compared to Propensity Score-Matched Bare Metal Stents in Contemporary Clinical Practice Robert J. Applegate et al TCT-607. Clinical Outcome in Chinese Patients with Long Lesion or Small Vessel/ Multivessel Disease Receiving XIENCE V Everolimus-Eluting Stent: Early Results from the SEEDS Study Yuejin Yang et al TCT-608. Two-Year Outcomes After Implantation of XIENCE PRIME and XIENCE PRIME Long Lesion Stents in Patients with Coronary Artery Disease: Results of the SPIRIT PRIME Multicenter Pivotal Clinical Trial Marco Costa et al TCT-610. Long-term Outcomes of Complete vs. Incomplete Revascularization After Drug-Eluting Stent Implantation in Patients with Multivessel Coronary Disease Zhan Gao et al TCT-611. Effect of Stent Inflation Pressure and Postdilatation on the Outcome of Coronary Artery Intervention: A Report of More Than 90,000 Stent Implantations Ole Fröbert et al TCT-612. Two-Year Outcomes Following Implantation of 32 mm and 38 mm Platinum Chromium Everolimus-Eluting Element Stents in Long Coronary Lesions Paul Teirstein et al TCT-613. A Prospective Randomized Multicenter Trial to Assess the Everolimus- Eluting Stent System (Promus Element) for Coronary Revascularization in a Population of Unrestricted Patients Jean Fajadet et al TCT-614. Remote Ischemic Preconditioning Improves Outcome out to Six-Years Following Elective Percutaneous Coronary Intervention: The CRISP-Stent Trial Stephen P. Hoole et al TCT-615. Coating Damage of Drug-Eluting Stent Occurs in Front Edge Strut: A Scanning Electron Microscopy Study Takashi Kubo et al TCT-616. Comparison of Long-term Outcomes with Everolimus-Eluting and Sirolimus- Eluting Stents in Small Coronary Artery Disease Hironori Kitabata et al TCT-617. How Do Results from RCTs and Registries Differ? Philip Urban et al TCT-618. Percutaneous Coronary Intervention in a Complex Patient Population: A Comparison of First- vs. Second- Generation Drug-Eluting Stent Use on In-Hospital and One-Year Outcomes Joshua P. Loh et al TCT-619. Prognostic Implications of Percutaneous Coronary Interventions Performed According to the Appropriate Use Criteria for Coronary Revascularization Israel Barbash et al TCT-620. What Is the Optimal Revascularization Strategy for Percutaneous Coronary Intervention of Distal Anastomotic Lesions After Coronary Bypass Surgery? Salem Badr et al TCT-621. Drug-Eluting Stent Event Registry of Thrombosis (DESERT): The International Drug-Eluting Stent Thrombosis Registry, Angiographic Assessment Ron Waksman et al TCT-622. Angiographic Outcomes in One-Stop Hybrid Coronary Revascularization vs. Percutaneous Coronary Intervention for the Treatment of Multivessel Coronary Artery Disease: A Propensity Score Matching Analysis Yi Shi et al TCT-623. Efficacy of Additional Ballooning with a Dual Wire Balloon After Rotational Atherectomy to Expand the Drug-Eluting Stent for Heavily Calcified Coronary Lesions Ryuichi Kato et al TCT-624. Clinical Outcomes with Everolimus- Eluting Stent for the Treatment of Cardiac Allograft Vasculopathy Babak Azarbal et al TCT-625. Three-Year Follow-up of a Randomized Comparison of Nobori, Biolimus A9-Eluting Stent with Cypher, Sirolimus-Eluting Stent for Coronary Revascularization in Japanese Population Takeshi Kimura et al TCT-626. Impact of Periprocedural Myocardial Infarction on In-Hospital and Two-Year Clinical Outcomes in Patients Undergoing Percutaneous Coronary Intervention with Drug-Eluting Stents Seung-Woon Rha et al TCT-627. Does Direct DES Stenting Reduce Restenosis? A Randomized Comparison of Direct Stent Implantation to Stenting with Predilation or Provisional Stenting in Elective PCI Patients Samer Somi et al TCT-628. Drug-Eluting Stent Implantation for the Treatment of Bare Metal or Drug-Eluting Stent Restenosis Shintaro Nezuo et al TCT-629. Real-world Comparison of Clinical Outcomes of Patients Who Received New Generation Platinum Chromium Everolimus- Eluting Stent vs. Cobalt Chromium Everolimus-Eluting Stent Ruogu Li et al TCT-630. ENERGY 1,000-Subject Registry with a Thin Strut Bare Metal Stent with Passive Coating Presenting One-Year MACE Data on Prespecified Subgroups Raimund Erbel et al TCT-632. Contemporary PCI Practices Across Three Continents: A Glimpse into the Preliminary Results of e-nobori Study Jawed Polad et al TCT-633. Impact of Ad Hoc Percutaneous Coronary Intervention with Drug-Eluting Stent in Angina Patients Young-Hak Kim et al TCT-634. Randomized Comparison of Direct Stenting with Conventional and Provisional Stent Implantation in Elective PCI Patients Using Bare Metal and Drug-Eluting Stents Samer Somi et al TCT-635. Cost-effectiveness of Everolimus- Eluting Stents Compared to First-Generation Drug-Eluting Stents in Contemporary Clinical Practice Robert J. Applegate et al TCT-636. Final Three-Year Results Following Resolute Zotarolimus-Eluting Stent Implantation in the RESOLUTE International Trial Franz-Josef Neumann et al TCT-637. A Novel Bioactive and Coating-Free Stent Surface Exhibits a Reduction in Neointimal Hyperplasia by Decreasing Platelet Aggregation and Promoting Endothelialization Adam Groothuis et al TCT-638. Late Catch-up Restenosis of Drug-Eluting Stents: Evidence from Comparison with Bare Metal Stents in Japanese CAD Patients Yuki Horita et al TCT-639. Two-Year Outcomes Following Implantation of the Resolute Zotarolimus- Eluting Stent in Vessels < 2.5 mm Diameter Ronald Caputo et al TCT-640. Very Late Stent Thrombosis Is Associated with Lower Mortality Than Early Stent Thrombosis: A Report from the VHA CART Program Ehrin J. Armstrong et al 80

83 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics TCT-641. The Effect of Balloon Angioplasty Compared with Drug-Eluting Stent (DES) Implantation for the Treatment of DES In-Stent Restenosis Taku Ichihashi et al TCT-642. Two Zotarolimus-Eluting Stent Generations: A Meta-analysis of 12 Randomized Trials vs. Other Limus-Eluting Stents and an Adjusted Indirect Comparison Salvatore Cassese et al TCT-643. Abluminal-Only Coating Everolimus- Eluting Coronary Stent Provides an Antiinflammatory Vascular Effect Compared to Bare Metal Stents in the Familial Hypercholesterolemic Swine Armando Tellez et al TCT-644. Drug-Eluting Stents in the Elderly: Very Long-term Clinical Outcomes (up to 10 Years) of Octogenarians in the DESIRE Registry Bruno Palmieri et al TCT-645. Comparison of Angiographic and Clinical Outcomes Among Patients with Sirolimus-, Paclitaxel-, Zotarolimus-, and Everolimus-Eluting Stent Implantation in Small Coronary Target Vessels and Long Lesions Soon Jun Hong et al TCT-646. Primary Results Following Percutaneous Coronary Intervention with the 38-mm Resolute Zotarolimus-Eluting Stent Shirish Hiremath et al TCT-647. Value of High-Density Lipoprotein Cholesterol in Predicting Future Cardiovascular Events of Patients with Low-Density Lipoprotein Cholesterol at the Time of Percutaneous Coronary Intervention Gabriel Sardi et al TCT-648. Impact of Stent Structural Design and Deployment Pressure on Strut Apposition and Recoil Nicolas Foin et al TCT-649. Safety and Efficacy of Overlapping Second Generation Drug-Eluting Stents Based Upon Two-Year Clinical Outcomes: Results from the Pooled Analysis of Five Trials from the International Global RESOLUTE Program Vasim Farooq et al TCT-650. Impact of the New BioMime Sirolimus-Eluting Stent in Complex Patients of Daily Practice: Preliminary Results of the merit-2 Study Vasim Farooq et al TCT-651. Feasibility and Clinical Outcomes of < 38 mm Long Drug-Eluting Stent Treatment for Diffuse Coronary Artery Disease in Egyptian Population Mohamed Loutfi et al TCT-652. A Comparison of Drug-Eluting Stents in a Bench Artery Dissection Model Joseph Berglund et al TCT-653. Assessment of Endothelial Function in Patients Randomly Treated with a Polymer-Free Sirolimus-Eluting Stent and Its Bare Metal Equivalent: Results of the VESTASYNC II Trial Breno Almeida et al TCT-654. Comparison in the Five-Year Outcome of Pericardium and Polytetrafluoroethylene-Covered Stents for Saphenous Vein Graft Lesions Sandeep Basavarajaiah et al TCT-655. Outcomes of High-Risk Patients Undergoing Percutaneous Coronary Interventions in the Ambulatory vs. In-Hospital Setting Mark Kahn et al TCT-656. Low Incidence of Stent Thrombosis in Asian Races: Multicenter Registry in Asia Seven-Year Follow-up Result Sunao Nakamura et al TCT-657. Multicenter, Prospective, Randomized, Single-Blind, Consecutive Enrollment Evaluation of Elixir DESyne Novolimus-Eluting Coronary Stent System with Durable Polymer to Endeavor Zotarolimus-Eluting Coronary Stent System: Three-Year Clinical and Nine-Month Angiographic and IVUS Results: EXCELLA II Study Stefan Verheye et al TCT-658. Do Drug Eluting Stents Improve Survival in All Comers? Tudor Vagaonescu et al TCT-659. Trends in Revascularization and Mortality for BMS and DES Coronary Stenting Procedures: A Medicare Study of 156,300 Patients Jasmine Patel et al TCT-660. Incidence and Predictors of Stroke Following Percutaneous Coronary Intervention in United States Vladimir Lakhter et al TCT-661. Clinical Relevance of Endothelial Dysfunction after Everolimus-Eluting Stent Implantation Compared to First Generation Drug-Eluting Stent Yoshifumi Nakajima et al TCT-662. One-Year Outcomes Following PCI in Patients with Asymptomatic CAD: A Report from the NHLBI Dynamic Registry Mohun Ramratnam et al TCT-663. A United Kingdom Perspective on the Appropriateness of Percutaneous Coronary Intervention in Stable Angina Benjamin J. Wrigley et al TCT-664. Seven-Year Clinical Outcomes of Sirolimus-Eluting Stent vs. Bare-Metal Stent: A Matched Analysis from a Real-world Single-Center Registry Jin-Sung Lee et al TCT-665. Profile and Outcome of Very Late Bare Metal Stent Thrombosis Treated with Percutaneous Coronary Intervention Ivan Gomez Blazquez et al TCT-666. Long-term Prognosis of In-Stent Restenosis After Drug-Eluting Stent Implantation and Predictors of Recurrent Restenosis: Data from the ASAN DES-ISR Registry Won-Jang Kim et al TCT-667. Restenosis After Coronary Stenting in 10,004 Patients with Follow-up Angiography Salvatore Cassese et al TCT-668. Everolimus-Eluting Stents vs. First-Generation Drug-Eluting Stents (Sirolimus or Paclitaxel) for Treatment of Drug-Eluting Stent In-Stent Restenosis Sachin S. Goel et al TCT-669. Incidence and Correlates of Stent Thrombosis up to 10 Years After Drug-Eluting Stent Implantation in Daily Clinical Practice Ricardo A. Costa et al TCT-670. Impact of Moderate and Severe Coronary Calcification on One-Year Outcomes After PCI with DES: A Pooled Analysis of 11,651 Patients from 14 Randomized Trials Philippe Généreux et al TCT-671. Drug-Eluting Stent Fracture: Guiding the Study of Today and Tomorrow s Stent Designs with Yesterday s Clinical Experiences Chad Abunassar et al TCT-672. Impact of Angiographical Lesion Complexity Score and In-Hospital Outcome After Percutaneous Coronary Intervention: Analysis from Japanese Multicenter Registry Ayaka Endo et al TCT-673. Drug-Eluting Stents vs. Bare Metal Stents for Saphenous Vein Graft Lesions: Meta-analysis of Randomized Trials Alban Dibra et al TCT-674. Implication of Periprocedural Biomarker Elevation After Stent Implantation: Analysis from the Pooled XIENCE V Trials Gregg W. Stone et al Tuesday - October 23,

84 Tuesday, October 23 Bioresorbable Vascular Scaffolds and Bioabsorbable Polymers TCT-563. Multicenter, First-in-Man Evaluation of the Myolimus-Eluting Bioresorbable Coronary Scaffold: Six-Month Clinical and Imaging Results Stefan Verheye et al TCT-564. Biodegradable-Polymer Biolimus Eluting Stents Show Better Antiproliferative Efficacy and Vascular Healing Pattern Than Permanent-Polymer Paclitaxel Eluting Stents in a Preclinical Coronary Model Armando Pérez De Prado et al TCT-565. NOYA I: A Prospective Randomized Trial of the Biodegradable Polymer NOYA Sirolimus-Eluting Stent Compared with the Durable Polymer FIREBIRD 2 Sirolimus- Eluting Stent in Patients with Coronary Artery Disease: Nine-Month Angiographic and 24-Month Clinical Results Kefei Dou et al TCT-566. SYNERGY Biodegradable Polymer Everolimus Eluting Coronary Stent: Porcine Vascular Compatibility and Polymer Safety Study Gregory J. Wilson et al TCT-567. Long-term Safety and Efficacy of Biodegradable Polymer-Coated Sirolimus- Eluting Stents in Real-World Practice: Five-Year Follow-up of the CREATE (Multicenter Registry of EXCEL Biodegradable Polymer Drug-Eluting Stents) Study Ya-Ling Han et al TCT-568. Real Polymer-Free Sirolimus- and Probucol-Eluting vs. Biodegradable Polymer Sirolimus-Eluting Stents for Obstructive Coronary Artery Disease: DKPLUS-Wave 1: A Multicenter, Randomized, Prospective Trial Shao Liang Chen et al TCT-569. Five-Year Clinical Outcomes of Biodegradable Polymer Biolimus-Eluting Stents vs. Durable Polymer Sirolimus-Eluting Stents in Patients With and Without Diabetes Mellitus: A LEADERS Substudy Axel Linke et al TCT-570. Stents with Absorbable Tissue- Deployable Coatings Can Distribute Drug More Uniformly Between Struts Abraham R. Tzafriri et al TCT-571. A Preliminary Study of Biodegradable Iron Stent in Mini-Swine Coronary Artery Chao Wu et al TCT-572. One-Year Preclinical Data on a Novel Drug-Eluting Stent with Amino Acid-Based Bioabsorbable Drug Carrier Mounted on an Integrated Delivery System (IDS) Jose Costa Jr et al TCT-573. Randomized Comparison of Biolimus-Eluting (Nobori) and Everolimus- Eluting (Xience/Promus) Stents in Patients with Multivessel Coronary Artery Disease: Twelve-Month Follow-up Data from COMPARE II Study Peter Smits et al TCT-574. Drug-Eluting Stent with Biodegradable Polymer in Patients with STEMI: Short- and Long-term Outcomes: Data from e-nobori and NOBORI 2 Trials Andres Iñiguez et al TCT-575. Different Vessel Healing Patterns Following Delivery of Everolimus and Paclitaxel Eluted from Biodegradable Polymer Coated Stents Implanted in Porcine Coronary Arteries Piotr P. Buszman et al TCT-576. COMPARE II: One-Year Clinical Data for the Treatment of Small Vessels (< 2.75mm) Peter Smits et al TCT-577. COMPARE II: One-Year Outcomes of a Large Randomized All-Comers Study Peter Smits et al TCT-578. First-in-Human Evaluation of a Novel Sirolimus-Eluting Stent with a Bioabsorbable Polymer for the Treatment of Single De Novo Noncomplex Coronary Lesions Erlon O. de Abreu-Silva et al TCT-579. One-Year Clinical Outcome of Biodegradable and Permanent Polymer Drug-Eluting Stents for Multivessel Disease or Long Lesion (< 28mm) in Patients with Stable and Unstable Angina Jun-Won Lee et al TCT-580. COMPARE II: One-Year Clinical Data of the Treatment of Long Lesions (> 20mm) Peter Smits et al TCT-581. Multislice Computed Tomography Angiography as a Noninvasive Angiographic and Functional Assessment of the 18-Month Performance of a Novel Radiolucent Bioresorbable Coronary Scaffolding Device (ABSORB Cohort B Trial) Patrick Serruys et al TCT-582. Eighteen-Month Clinical and Imaging Results from the DESSOLVE I First-in-Human Trial of the MiStent SES with Absorbable Polymer John A. Ormiston et al TCT-583. Multicenter, Prospective, Randomized, Single-Blind, Consecutive Enrollment Evaluation of Novolimus-Eluting Coronary Stent System with Bioabsorbable Polymer Compared to a Zotarolimus-Eluting Coronary Stent System: Twleve-Month Clinical and Six-Month Angiographic and IVUS Results: The EXCELLA BD Study Alexandre Abizaid et al TCT-584. Nine-Month Imaging and 12-Month Clinical Results from the DESSOLVE II Randomized Trial of the MiStent SES with Absorbable Polymer William Wijns et al Carotid and Neurovascular Disease and Intervention TCT-190. Use of Optical Coherence Tomography (OCT) for Characterization of Carotid Plaque in Patients with Severe Asymptomatic Carotid Stenosis Mehmet Cilingiroglu et al TCT-191. Percutaneous Transluminal Angioplasty and Stenting of Extracranial Vertebral Artery Stenoses Isabelle Henry et al TCT-192. Vertebral Angioplasty Stenting: Are Protection Devices Useful? Isabelle Henry et al TCT-193. Use of Drug-Eluting Balloon for the Treatment of In-Stent Restenosis After Carotid Artery Stenting Piero Montorsi et al TCT-194. Impact of Asymptomatic New Cerebral Lesions in DW-MRI After Carotid Artery Stenting on Long-term Prognosis Klaudija Bijuklic et al TCT-195. Novel Quantitative Virtual Histology Parameters in the Asymptomatic and Symptomatic Carotid Atherosclerotic Plaque Imaging: Data from the First 222 Patients in CRACK-VH Study Piotr Musialek et al TCT-196. Chronic Cerebrospinal Venous Insufficiency: The Association Between the Extent of Extracranial Venous Anomalies and Clinical Severity and Duration of Multiple Sclerosis Juraj Madaric et al TCT-197. Carotid Artery Stenting With or Without Predilatation, Protected, or Unprotected: Acute Results and Complications Alexander Kypta et al TCT-198. EuroScore Risk Model as Predictor of Early and One-Year Results After Carotid Artery Stenting and Carotid Endarterectomy Pavel Bolotov et al 82

85 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics TCT-199. The Transradial Approach Is Safe and Effective for Carotid Artery Stenting Sasko Kedev et al TCT-200. Endovascular Revascularization for Cerebral Ischemia in Takayasu Arteritis: Five-Year Experience Amar N. Patnaik et al TCT-201. Intravascular Ultrasound (IVUS) Validation of Noninvasive and Invasive Measures of Carotid Stenosis Severity in CARUS (Carotid Artery intravascular Ultrasound academic registry) Piotr Musialek et al TCT-202. Effect of Contralateral Occlusion on Index Internal Carotid Artery (ICA) Duplex Doppler Velocities: Quantitative Analysis Using Intravascular Ultrasound (IVUS) to Match Index ICA Stenosis Severity. Piotr Musialek et al TCT-203. Reproducibility of In Vivo Virtual Histology Intravascular Ultrasound Evaluation of the Carotid Atherosclerotic Plaque Using Novel Quantitative Parameters Piotr Musialek et al Cath Lab Advances TCT-314. A Bridging Solution for Hybrid Operating Suites: Periprocedural New Generation C-Arm Imaging During Cardiac Interventional Procedures Guy Friedrich et al TCT-315. A Hybrid Simulator for Femoral Artery Access Training Erhard Kaiser et al TCT-316. Radiation Dose Surveillance Using Automated, Remote-Site Dose Monitoring in Cardiac Catheterization Laboratories Across Asia-Pacific Punitha Arasaratnam et al TCT-317. Implementation of a Real-time Skin Dose Tracking System in a Cardiac Catheterization Laboratory Neil Dashkoff et al TCT-318. Contrast Agent and Radiation Exposure in Revascularisation of Chronic Coronary Total Occlusions: Magnetic Navigation vs. Conventional PCI Sabine Scherzer et al TCT-319. Improvement of Coronary Lesions Quantification with Rotational Angiography XperSwing Leire Unzue et al TCT-320. Rotational Angiography with Xperswing Technique: Comparative Analysis of Radiation Dose Compared to Conventional Angiography Leire Unzue et al TCT-321. Rotational Angiography with Xperswing: Safety and Accuracy Compared to Conventional Angiography Leire Unzue et al TCT-322. Radiation Exposure in Standard Views During Diagnostic Coronary Angiography Pranjal K. Boruah et al TCT-323. Preprocedural Fasting for Diagnostic and Interventional Coronary Procedures: Is It Neccessary? Tahir Hamid et al TCT-324. New Simulation System for Percutaneous Coronary Intervention Training Improves Resident Performance Makoto Hyodo et al TCT-325. Patients Skin Radiation Doses in a Contemporary Cohort of Patients Undergoing Percutaneous Interventional Cardiology Procedures Juan M. Nogales-Asensio et al TCT-326. The Occupational Effects of Interventional Cardiology Results from the WIN for Safety Survey Makoto Hyodo et al TCT-327. Rotational Angiography with 3-D Reconstruction Following Motion Field Estimation for Evaluation of Geometry of the Implanted Medtronic CoreValve Frame: Comparison with MSCT Carl J. Schultz et al TCT-328. C-Arm Angiography (DYNA-CT) for 3-D Coronary Reconstruction and Myocardial Perfusion Assessment Harald Rittger et al TCT-329. Effectiveness of Fluoroscopy-Save vs. Cinematography at Reducing Radiation Exposure During Diagnostic Coronary Angiography: A Randomized Controlled Trial Binita Shah et al TCT-330. The Effect of Automated Contrast Injection Systems on Contrast Volume Use During Diagnostic Coronary Angiography and Percutaneous Coronary Interventions Shahar Lavi et al TCT-331. Experience Is Associated with Shorter Procedure Time and Reduced Radiation with Robotic-Enhanced Coronary Intervention: Results from the PRECISE Multicenter Study Giora Weisz et al TCT-332. Validation of Transapical Access Accuracy of Computed Tomographic Angiography-Fluoroscopy Fusion-Guided Structural Heart Disease Interventions Bryce N. Einhorn et al TCT-333. New Simulation System for Percutaneous Coronary Intervention Training: Rhythmically Beating Vascular Model Makoto Hyodo et al TCT-334. Fusion of a Full-Scale Patient Simulator with an Endovascular Simulator to Improve Quality of Human Factors Training with Cath Lab Teams Erhard Kaiser et al TCT-335. MITOS Multimodality Imaging Operating System Andreas Melzer et al TCT-336. Patient-Specific Rehearsal Prior to Endovascular Aneurysm Repair: A Pilot Study Liesbeth M. Desender et al Chronic Kidney Disease and Acute Renal Insufficiency TCT-133. Role of Arterial Stiffness and Impaired Renal Function in the Progression of Nonculprit Coronary Lesions After Percutaneous Coronary Intervention Hidehiro Kaneko et al TCT-135. Contrast Use and Acute Kidney Injury in Contemporary Clinical Practice Robert J. Applegate et al TCT-136. Impact of Preoperative Chronic Kidney Disease on Transcatheter Aortic Valve Implantation Outcome Nicolas Dumonteil et al TCT-137. Is Urinary Neutrophil Gelatinase- Associated Lipocalin the Renal Troponin in Invasive Cardiology? Tilman Perrin et al TCT-138. Veropaque: A Novel Contrast Formulation Mitigates Contrast-Induced Acute Kidney Injury Gerold Mosher et al TCT-139. Prognosis and Incidence of Acute Kidney Injury According to the Valve Academic Research Consortium After Transcatheter Aortic Valve Implantation Marc Bedossa et al TCT-140. Trend of Clinical Outcomes in Patients with Chronic Kidney Disease and End-Stage Renal Disease Following Percutaneous Coronary Intervention James E. Lai et al TCT-141. Age, Glomerular Filtration Rate, Ejection Fraction, and the AGEF Score Are Predictors of Contrast-Induced Nephropathy (CIN) in Patients with ST-Elevation Myocardial Infarction (STEMI) Undergoing Primary PCI Giuseppe Ando et al Tuesday - October 23,

86 Tuesday, October 23 TCT-142. Association of Acute Kidney Injury with Mortality Post TAVR Elizabeth M. Holper et al TCT-144. Impact of Chronic Kidney Disease on Platelet Reactivity and Clinical Outcomes of Patients Undergoing Percutaneous Coronary Intervention Fabio Mangiacapra et al TCT-145. The Significance of VARC-Defined Acute Kidney Injury After Transcatheter Aortic Valve Implantation Using the Balloon-Expandable Edwards Bioprosthesis Muhammed Z. Khawaja et al TCT-146. The Effect of Drug-Eluting Stents on Clinical and Angiographic Outcomes in Renal Failure Patients with Dialysis: Multicenter Registry in Asia Sunao Nakamura et al TCT-147. High-Dose Atorvastatin Pretreatment for Preventing Contrast-Induced Nephropathy in Patients Receiving Primary Percutaneous Coronary Intervention: Prespecified Substudy of a Prospective Randomized Clinical Trial Hyun-Sook Kim et al TCT-148. Blood Transfusion and the Risk of Acute Kidney Injury Following Transcatheter Aortic Valve Implantation Rutger-Jan Nuis et al TCT-149. Impact of Chronic Kidney Disease on Myocardial Infarct Size and Adverse Events in ST-Elevation Myocardial Infarction: Results from the INFUSE-AMI Trial Usman Baber et al TCT-150. Prognostic Value of Different Definitions of Contrast Induced Acute Kidney Injury in STEMI: Analysis from the HORIZONS-AMI Trial Rudolf Jarai et al Chronic Total Occlusions TCT-439. Incidence of Procedural Complications in Patients Undergoing Percutaneous Coronary Chronic Total Occlusion Interventions: A Systematic Review and Meta-analysis Vishal G. Patel et al TCT-440. Two-Year Clinical Outcomes of Primary Stenting of Totally Occluded Native Coronary Arteries III (PRISON III): A Randomized Comparison of Sirolimus- Eluting Stent Implantation with Zotarolimus- Eluting Stent Implantation for the Treatment of Total Coronary Occlusions Koen Teeuwen et al TCT-441. Enhanced Endothelial Tubule Formation in Response to Proly-Hydroxylase Inhibitor FG-2216: A Step Towards Therapeutic Angiogenesis in Chronic Total Occlusions Benjamin J. Wrigley et al TCT-442. The Impact of High Residual Platelet Reactivity After Clopidogrel Loading on Cardiac Mortality in Patients Treated by Percutaneous Coronary Intervention for Chronic Total Occlusion Renato Valenti et al TCT-443. Predictors of Reocclusion After Successful Drug-Eluting Stent Supported Percutaneus Coronary Intervention for Chronic Total Occlusion Renato Valenti et al TCT-444. Chronic Total Occlusion Lesion Revascularization Alone vs. Complete Revascularization in Chronic Total Occlusion Patients with Multivessel Disease Seung-Woon Rha et al TCT-445. Radial vs. Femoral Access for Percutaneous Coronary Interventions in Patients with Chronic Total Occlusion Thierry Lefèvre et al TCT-446. Long-Term Clinical Outcomes After Percutaneous Coronary Intervention for Chronic Total Occlusions in Elderly Patients (< 75 years): Five-Year Outcomes from a 1,791 Patient Multinational Registry Loes Hoebers et al TCT-447. Effects of Vibration on Frictional Resistance During Angioplasty Device Insertion: Possible Application of a Newly Designed Support System to Complex Coronary Intervention Satoru Sakamoto et al TCT-449. Short- and Long-term Clinical Outcomes of Chronic Total Occlusion Treatment with a Latest Generation Drug-Eluting Stent Alejandro Alcocer Chauvet et al TCT-450. Improvement in LV Systolic Function with Ischemia-Guided (Fractional Flow Reserve) Chronic Total Occlusion (CTO) Intervention Mayank Agrawal et al TCT-451. Application of the Hybrid Approach to Chronic Total Occlusion Interventions Tesfaldet T. Michael et al TCT-452. Drug-Eluting Stents for the Treatment of Chronic Total Occlusion: A Comparison with Sirolimus, Paclitaxel, Zotarolimus (Endeavor Resolute), BiolimusA9, EPC Capture and Everolimus- Eluting Stent: Multicenter Registry in Asia Sunao Nakamura et al TCT-453. Serial Angiographic Follow-up After Successful Implantation of Sirolimus-, Paclitaxel-, Everolimus-, and Zotarolimus- Eluting Stents for Chronic Total Occlusions: Multicenter Registry in Asia Sunao Nakamura et al TCT-454. Periprocedural Myocardial Infarction in Chronic Total Occlusion Percutaneous Coronary Interventions: A Systematic Cardiac Biomarker Evaluation Study Nathan Lo et al TCT-455. Coronary Chronic Total Occlusion Revascularization: Immediate Procedural Outcomes from a Multicenter US Registry Tesfaldet T. Michael et al TCT-456. Radial Approach to CTO Recanalisation Is as Successful and Safer Than Femoral: Single Centre Observational Study Solomon D. Asgedom et al Diabetic Patients TCT-337. Clinical Outcome of Diabetic and Nondiabetic Patients Treated with Second- Generation Zotarolimus-Eluting and Everolimus-Eluting DES Kenneth Tandjung et al TCT-338. Meta-analysis of Percutaneous Coronary Intervention vs. Coronary Artery Bypass Graft Surgery in Patients with Diabetes and Left Main and/or Multivessel Coronary Artery Disease Yu Jie Zhou et al TCT-339. Comparison of 12-month Clinical Outcomes in Patients with Chronic Total Occlusion (CTO) Lesion Between Diabetic and Nondiabetic: A Multicenter Study of e-cto Investigators Cheol Ung Choi et al TCT-340. Efficacy and Safety of Biodegradable Polymer Biolimus-Eluting Stents vs. Durable Polymer Everolimus- Eluting Stents in Diabetic Patients: A Prospective Nonrandomized Single-Center Long-term Comparison Pierre Sprimont et al TCT-341. Impact of Chronic Statin Therapy on Development of Glucose Intolerance and New Onset Diabetes Mellitus in Asian Population Sang-Ho Park et al TCT-342. Impact of Diabetes Mellitus on Clinical Outcomes After Percutaneous Coronary Intervention with Drug-Eluting Stents for Unprotected Left Main Coronary Artery Disease Thierry Lefèvre et al 84

87 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics TCT-343. Paclitaxel Drug-Eluting Balloon vs. Standard Angioplasty to Reduce Restenosis in Diabetic Patients with In-Stent Restenosis of the Superficial Femoral and Proximal Popliteal Artery Francesco Liistro et al TCT-344. Importance of Optimal Reperfusion in Diabetic Patients Treated with Primary Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction M.A. Velders et al TCT-345. Effect of Body Mass Index and Diabetes Mellitus on Angiographic Outcomes in Patients Undergoing Primary Percutaneous Coronary Intervention Using Different Drug-Eluting Stents Seiji Habara et al TCT-346. Clinical Impact of Five-Month Follow-up Glycosylated Hemoglobin on Cardiovascular Outcomes in Diabetic Patients with ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention Hye Won Lee et al TCT-347. Clinical Outcome of Biolimus-Eluting vs. Sirolimus-Eluting Coronary Stent Implantation In Patients With and Without Diabetes Mellitus: A SORT OUT V Substudy Michael Maeng et al TCT-348. The Effect of Drug-Eluting Stents on Clinical and Angiographic Outcomes in Diabetic Patients, Three-Years Results: Multicenter Registry in Asia Sunao Nakamura et al TCT-349. Drug-Eluting Stents for the Treatment of Small Coronary Artery with Diabetes Mellitus: A Comparison with Sirolimus, Paclitaxel, Zotarolimus (Endeavor Resolute), Biolimus A9, EPC Capture, and Everolimus-Eluting Stent: Multicenter Registry in Asia Sunao Nakamura et al TCT-350. Drug-Eluting Stents for the Treatment of Very Long Coronary Artery Stenosis with Diabetes Mellitus: A Comparison with Sirolimus, Paclitaxel, Zotarolimus (Endeavor Resolute), Biolimus A9, EPC Capture, and Everolimus-Eluting Stent: Multicenter Registry in Asia Sunao Nakamura et al TCT-351. The Obesity Paradox in Patients with Diabetes Mellitus After Percutaneous Coronary Intervention with Sirolimus-Eluting Stent: Comparison of De Novo and In-Stent Restenosis Lesions Yoshikazu Shigemoto et al TCT-352. Angiographic Features of Atherosclerotic Superficial Femoral Artery Disease in Diabetics and Nondiabetics Presenting with Claudication Atif Mohammad et al TCT-353. Long-term Outcomes of Biodegradable Polymer Drug-Eluting Stents vs. Durable Polymer Sirolimus-Eluting Stents in Patients with Diabetes: A Pooled Analysis of Individual Patient Data from the ISAR-TEST 4 and LEADERS Randomized Trials Lamin King et al TCT-354. Plaque Excision Is an Effective Treatment Option for Diabetic Patients: Results from the DEFINITIVE LE Study Lawrence Garcia et al TCT-355. Coronary Stents in Patients with Diabetes Mellitus: The Diabetes and Drug-Eluting Stent (DiabeDES IV) Randomized Angiography Trial Michael Maeng et al TCT-591. Biological Efficacy and Vessel Healing of Second Generation Paclitaxel Coated Balloons: A Comparative Study with the Original PACCOCATH Technology in the Iliofemoral In-Stent Restenosis Model in the Familial Hypercholesterolemic Swine Piotr P. Buszman et al TCT-592. Familial Hypercholesterolemic Swine In-Stent Restenosis Model but Not Contemporaneous Injury Plus Treatment Model, Predicts Efficacy of Drug-Coated Balloon in Peripheral Arteries Maxwell E. Afari et al TCT-594. Efficacy and Safety of Drug-Eluting Balloon Compared to Drug-Eluting Stent for the Treatment of In-Stent Restenosis (ISR) Myung-Hyun Kim et al TCT-595. Pantera Lux Drug Coated Balloon: 12-Month Results on 1,064 Patients of the International DELUX Registry Gert Richardt et al TCT-596. Pantera Lux Drug-Coated Balloon: 12-Month Results on the Diabetics Subgroup of the International DELUX Registry Christoph Naber et al TCT-597. Acute Delivery and Long-term Retention of Sirolimus Nanoparticles Using a Novel Porous Angioplasty Balloon in the Porcine Coronary Model Armando Tellez et al TCT-598. Luminal Fibrin as a Key Component in Mechanism of Action in Drug-Coated Balloon Technologies Armando Tellez et al TCT-599. Angiographic and Clinical Outcome in the Treatment of Restenosis of Drug- Eluting Stents with Drug Coated Balloons in Diabetics: Insights from the PEPCAD- DES Study Harald Rittger et al TCT-600. Angiographic and Clinical Outcomes of Paclitaxel Coated Balloon Angioplasty vs. Uncoated Balloon Angioplasty in Drug- Eluting Stent Restenosis: Insights from the PEPCAD-DES Study Harald Rittger et al Tuesday - October 23, 2012 Drug-Coated Balloons TCT-585. Six-Month Results of the BIOLUX PI First-in-Man Study Comparing a Paclitaxel- Releasing Balloon Catheter vs. an Uncoated Balloon Catheter in Femoropopliteal Lesions Dierk Scheinert et al TCT-586. Impact of Restenosis Pattern on Angiographical Outcomes After Paclitaxel- Eluting Balloon Angioplasty for Drug-Eluting Stent Restenosis Shunsuke Kubo et al TCT-587. Drug-Coated Balloon for De Novo Coronary Lesions: Results from the Valentines II Trial Ron Waksman et al TCT-588. Cost-effectiveness of Paclitaxel- Coated Balloon Angioplasty for Treatment of Coronary Restenosis in Bare-Metal Stents Klaus Bonaventura et al TCT-589. Reaching Further in the Treatment of Calcified Small Vessel Disease: Is Rota-DEB an Option? Paula Mota et al TCT-590. Efficacy of Paclitaxel-Eluting Balloon Catheter in Patients with Recurrences After Drug-Eluting Stent Implantation for In-Stent Restenosis Seiji Habara et al Endovascular Aortic Repair and Thoracic Endovascular Aortic Repair TCT-115. Hybrid Endovascular Repair for Aortic Arch Pathology: Intermediate Outcomes and Complications Woong Chol Kang et al 85

88 Tuesday, October 23 TCT-116. A New Concept ostent: The Multilayer Flow Modulator; First-in-Human Study in Thoracoabdominal and Abdominal Aortic Aneurysms Michel C. Henry et al TCT-117. Periprocedural and Follow-up Outcomes After Endovascular Abdominal Aortic Aneurysm Repair by Interventional Cardiologists Abhijeet Basoor et al TCT-118. Successful EVAR for Short-Necked Abdominal Aortic Aneurysms Using Balloon Expandable Stents by Interventional Cardiologists Abhijeet Basoor et al TCT-119. The Clinical Significance of Coronary Angiography in Elderly Patients Undergoing Endovascular Repair for Type B Aortic Dissection Pengcheng He et al TCT-120. The Policy of Total Percutaneous Abdominal Aortic Aneurysm Repair: One-Year Follow-up Juraj Madaric et al TCT-121. Thoracic Aortic Pseudoaneurysm Following Endovascular Stent Graft Placement for Treatment of Type B Dissection: What Causes It? Rolf Alexander Janosi et al TCT-122. Endovascular Stent-Graft Implantation in Patients with Unstable Acute Intramural Hematoma: Is Endovascular Repair for Intramural Hematoma Over- Treatment or Suitable Treatment? Hyunmin Choi et al TCT-123. Initial Experience of Chimney Technique in Case of Aortic Arch Pathologies Involving the Supra-Aortic Branches Renat S. Akchurin et al TCT-124. Endovascular Repair of Abdominal and Iliac Aneurysm Repair with Preservation of Pelvic Flow Patick Kelly et al TCT-125. A Novel Antimicrobial-Bonded Aortic Graft for Aortic Graft Infection Ibrahim Aboshady et al TCT-126. Endurant US Pivotal Trial: Two-Year Outcomes Brij Maini et al TCT-127. The Impact of Later Generation Thoracic Aortic Stent Grafts as Demonstrated in the VALOR II Trial Zvonimir Krajcer et al TCT-128. Disruptive Endovascular Technology with Multilayer Flow Modulator Stents (MFM) as a Therapeutic Option in the Management of Thoracoaortic Aneurysms: Early Results from MFM Registry Sherif Sultan et al TCT-129. Contemporary Comparison of the Paradigm Shift in Rupture AAA Management; 12-Year Experience in a Tertiary Referral Centre of Endovascular Repair of RAAA (REVAR) vs. Open Repair (OR) Sherif Sultan et al TCT-130. Clinical Efficacy and Cost per Quality-Adjusted Life Years with Pararenal Endovascular Aortic Repair (PEVAR) for Pararenal AAA Compared with Open Surgical Repair Niamh Hynes et al TCT-131. Cerebral Ischemia After Thoracic Endovascular Aortic Repair: A Diffusion- Weighted Magnetic Resonance Imaging Study Philipp Kahlert et al Gender, Age, and Other Demographic Considerations TCT-356. Circumferential Therapeutic Ultrasound for the Treatment of Resistant Hypertension: Preliminary Results of Human Feasibility Study (SOUND-ITV) Peter Neuzil et al TCT-357. Trends and Outcomes of Primary Percutaneous Coronary Intervention (PPCI) in Octogenarians Including a Comparison Between Radial and Femoral PPCI Strategies: A Single-Centre Experience Parisha Khan et al TCT-358. Food and Drug Administration Approved Cardiovascular Medical Devices: A 10-Year Review of the Participation of Women and Ethnic Subgroups Beverly Gallauresi et al TCT-359. Percutaneous Coronary Intervention In Octogenarians: Single, High-Volume, United Kingdom Center Experience Refai Showkathali et al TCT-360. Is There a Difference of Management for ST-Elevation Myocardial Infarction Regarding Gender? Myth or Reality? Data from a Prospective Registry of 5,000 Patients Marc Bedossa et al TCT-361. Gender-Based Analysis of Everolimus-Eluting Stent Safety in the Bern-Rotterdam Cohort Giulio G. Stefanini et al TCT-362. Incidence, Background, Treatment Strategies and the Prognosis in Very Elderly Patients with Acute Myocardial Infarction: From Japanese Multicenter Database Takafumi Yamane et al TCT-363. Safety and Long-term Outcomes After Percutaneous Coronary Interventions in Patients with Liver Disease: Report from the National Heart, Lung, and Blood Institute Dynamic Registry Oscar Marroquin et al TCT-364. Gender Related Disparity in Cardiovascular Risk Factors and Treatment Options Keyur Parikh et al TCT-365. Cardiovascular Screening in OB/ GYN Clinics for Early Identification and Referral of Women at Risk: Results from the Women s Heart Health Initiative, an OB/GYN Screening Pilot Program Roxana Mehran et al TCT-366. Impact of Gender on Adverse Cardiac Events in Patients with Large Anterior Myocardial Infarction: Results from the INFUSE-AMI Trial Nilusha Gukathasan et al TCT-367. Gender Impact on Patients Treated with Drug-Eluting Stents: Three-Year Follow-up Data Fazilatum Nesa Malik et al TCT-368. Lower Socioeconomic Status Predicts Major Adverse Cardiac Events (MACE) and Increased Mortality Post- Percutaneous Intervention (PCI): Independent Hazard vs. Intersection of Modifiable Risk Factors? Sandeep Nathan et al TCT-369. Comparison of Target Lesion and Vessel Revascularization in Women of Different Age Groups After Percutaneous Coronary Intervention for Acute Coronary Syndrome Soha Ahmad et al TCT-370. Outcomes According to Sex Following Unprotected Left Main Stenting with Drug-Eluting Stents: The Milan Experience Gill L. Buchanan et al Heart Failure, LV Dysfunction, and Shock TCT-372. Coronary Artery Disease in Patients with Reduced Left Ventricular Systolic Function Treated with Medicine, Surgery, or Percutaneous Coronary Intervention: A Retrospective Review of Outcomes Within a Multicenter Health Care System Matthew LaBarbera et al TCT-373. Impact of Epicardial Fat Volume on Coronary Artery Disease in Symptomatic Patients with a Zero Calcium Score Tsuyoshi Ito et al 86

89 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics TCT-374. Long-term Survival and Neurological Outcome of In-Hospital Cardiac Arrest Patients Rescued by Extracorporeal Cardiopulmonary Resuscitation Jin-Ho Choi et al TCT-375. Optimizing Rotational Atherectomy in High-Risk Percutaneous Coronary Interventions: Insights from the PROTECT Study Mauricio G. Cohen et al TCT-376. SIMPLIPHieDE Study: Single-Center IMPella LVAD Supported PCI in High-Risk Group of Patients: Detroit Medical Center Experience: Clinical Outcomes Haroon Faraz et al TCT-377. Impact of New Onset Acute Heart Failure in Patients with Acute Myocardial infarction Underwent Successful Revascularization Keun-Ho Park et al TCT-378. Interim Analysis of the Reitan Catheter Pump (RCP) Heart Failure Efficacy Study: RCP Improves Cardiovascular and Renal Function in Acute Decompensated Heart Failure (ADHF) Thomas R. Keeble et al TCT-379. Percutaneous Transcatheter Aortic Valve Closure Successfully Treats Left Ventricular Assist Device-Associated Aortic Insufficiency and Improves Cardiac Hemodynamics Kishan S. Parikh et al TCT-380. Hemodynamic Effects of a Catheter-Deployed Intra-Aortic Micro-Axial Entrainment Pump in a Porcine Acute HF Model Joggy George et al TCT-381. First Report of Acute and Short-term Outcomes from a Confirmatory (Cohort B) Study of Percutaneous Ventricular Restoration (PVR) Therapy Using the Parachute Device in Patients with Ischemic Dilated Heart Failure Martyn Thomas et al TCT-382. Percutaneous and Surgical Circulatory Support for Medically Refractory Right Ventricular Failure with a Centrifugal- Flow Pump Navin K. Kapur et al TCT-383. Transcutaneous-Powered Electrohydraulic Counterpulsation System for Ambulatory Nonobligatory Chronic Heart Failure Treatment William E. Cohn et al TCT-384. The Coronary Sinus Reducer: A Device-Based Therapy for Refractory Angina: Interim Safety Results of the Ongoing COSIRA Clinical Trial and Efficacy Results of the CS Reducer Registry Shmuel Banai et al TCT-385. Comparative Economic Outcomes in Cardiogenic Shock Patients Managed with the Minimally Invasive Impella or Extracorporeal Life Support Anson Cheung et al TCT-386. Predictors of In-Hospital Mortality in Patients Undergoing Pericardiocentesis in United States Paul L. Hermany et al TCT-387. Short- and Long-term Outcomes of Coronary Revascularization in Patients with Severe Left Ventricular Dilatation Nie Shaoping et al TCT-388. Multislice Computer Tomography Analysis of Percutaneous Ventricular Restoration (PVR) Using the Parachute Device in Patients with Heart Failure Post Anterior Wall Myocardial Infarction: First-in-Man Experience Hiram Bezerra et al TCT-389. Acute and Six-Month Clinical and Echocardiographic Outcomes of the First-in-Human Experiences with the Implantation of a Novel Catheter-Based Ventricular Partitioning Device in Patients with Ischemic Heart Failure and Dilated Left Ventricle Marco Costa et al TCT-390. Outcome of the Impella Device for Acute Mechanical Circulatory Support Anthony Lemaire et al TCT-391. Selected CD133+ Endothelial Progenitor Cells to Create Angiogenesis in No-Option Patients: Preliminary Results of Safety and Feasibility Pilar Jimenez-Quevedo et al Imaging TCT-241. Value of Optical Coherence Tomography Beyond the Napkin Ring Sign in CT Angiography for Detecting Coronary Lipid-Core Plaques as Determined by Histology: A Multimodality Imaging Study in Human Donor Hearts Christopher L. Schlett et al TCT-242. Accuracy of Optical Coherence Tomography Measurement Compared to Intravascular Ultrasound: OPUS-CLASS Study Takashi Akasaka et al TCT-243. Comparison of Neointimal Coverage of Everolimus-Eluting Stents and Sirolimus- Eluting Stents: Optical Coherence Tomography Subanalysis from the RESET Trial Takashi Akasaka et al TCT-244. Impact of Intensive Statin Therapy on Plaque Characteristics as Assessed by Serial Optical Coherence Tomography Takashi Akasaka et al TCT-245. Impact of Statin Therapy on Plaque Microstructures on Optical Coherence Tomography Yu Kataoka et al TCT-246. Comparison of Intravascular Ultrasound vs. Angiography-Guided Drug-Eluting Stent Implantation: A Meta-analysis of Randomized Trials and Observational Studies Involving 17,570 Patients Yaojun Zhang et al TCT-247. Incidence and Characterization of Stent Dissections in Women vs. Men: A Report from the Massachusetts General Hospital Optical Coherence Tomography Registry Magdalena A. Zeglin-Sawczuk et al TCT-248. Early and Late Stent Thrombosis: Different Clinical Entities? IVUS Findings Leire Unzue et al TCT-249. Different Optical Coherence Tomography Neointimal Tissue Appearance of Drug-Eluting Stent Restenosis After Bifurcation Stenting Satoko Tahara et al TCT-250. Predictors of In-Stent Restenosis by Optical Coherence Tomography Derived Tissue Characterization in the Novel In-Stent Neointimal Hyperplasia Model of Familial Hypercholesterolemic Swine Piotr P. Buszman et al TCT-251. Impact of Plaque Composition Assessed by imap-intravascular Ultrasound on Elevation of High Sensitive Cardiac Troponin T After Percutaneous Coronary Intervention Seiji Koga et al TCT-252. Impact of Prediabetic Status on Coronary Atherosclerosis: A Multivessel Angioscopic Study Osamu Kurihara et al TCT-253. Patient and Lesion Characteristics of Peripheral Artery Disease Concomitant with Coronary Artery Disease: Insights from Virtual Histology Intravascular Ultrasound Analysis Daisuke Ogasawara et al Tuesday - October 23,

90 Tuesday, October 23 TCT-254. Epicardial Fat Volume and Coronary Plaque Characteristics Kennosuke Yamashita et al TCT-255. Peri-Strut Low Intensity Areas Identified by Optical Coherence Correlated with the Degree of Neointimal Formation After Three-Years Following Stent Implantation in Humans Jin-Ho Choi et al TCT-256. Evaluation of Coronary Arterial Calcification Using Ex Vivo Imaging by Optical Frequency Domain Imaging Takeshi Ijichi et al TCT-257. Angioscopy Study from a Large Patient Population Comparing Sirolimus- Eluting Stent with Biodegradable vs. Durable Polymer Shao Liang Chen et al TCT-258. Impact of the Type of the Underlying Plaque on the Neointima Tissue Developed After a Bioresorbable Scaffold Implantation: A Serial Optical Coherence Tomography Study Christos V. Bourantas et al TCT-259. Impact of Stent Edge Plaque Burden on Lumen Preservation After DES Implantation: A 3-D IVUS Analysis from the J-DESsERT Trial Hideki Kitahara et al TCT-260. Coronary Artery Plaque Regression and Change in Plaque Composition Associated with Statin Therapy Extend for a Long-term: Results from the Extended TRUTH Study Tsuyoshi Nozue et al TCT-261. Five-Year Clinical Outcomes of the OLIVUS-Ex (Impact of OLmesartan on progression of coronary atherosclerosis: Evaluation by IntraVascular UltraSound Extension) Trial Atsushi Hirohata et al TCT-262. Effect of Statin Pretreatment on the Morphology of Coronary Culprit Plaques in Patients with Stable Angina Pectoris: An Intravascular ultrasound and Optical Coherence Tomography Study Kenichiro Saka et al TCT-263. Coronary Evaginations Are Caused By Positive Vessel Remodeling and Are Nearly Absent Following Implantation of Newer-Generation Drug-Eluting Stents: An Optical Coherence Tomography and Intravascular Ultrasound Study Maria D. Radu et al TCT-264. Relation Between Peak High Sensitivity CRP Levels Before Coronary Angiography and Culprit Lesion Morphology in Non-ST-Segment Elevation Acute Coronary Syndrome: An Optical Coherence Tomography Study Kenichiro Saka et al TCT-265. Combination of Large Plaque Burden and Low Wall Shear Stress Results in Greater Progression of Coronary Atherosclerosis than Low Wall Shear Stress Alone in Patients with Coronary Artery Disease Michel T. Corban et al TCT-266. Frequency of Spotty Calcification Among Lipid-Core Plaques Using Combined Intracoronary Near-Infrared Spectroscopy and Intravascular Ultrasound Ryan D. Madder et al TCT-267. Comparison of Coronary Plaque Components Between Nonculprit Lesion in Patients with Acute Coronary Syndrome and Target Lesion in Patients with Stable Angina: Virtual Histology-Intravascular Ultrasound Analysis Young Joon Hong et al TCT-268. Incidence and Predictors of Tissue Prolapse After Percutaneous Coronary Intervention for Saphenous Vein Graft Disease: Intravascular Ultrasound Study Young Joon Hong et al TCT-271. Stent Thrombosis After Intravascular Ultrasound-Guided Stent Implantation Yoshihide Fujimoto et al TCT-272. The Role of Macrophage Accumulations on Bare Metal Stent Failure Presenting with Acute Coronary Syndrome: Observation by Optical Coherence Tomography Yuetsu Kikuta et al TCT-273. Serial Evaluation of Peri-Strut Low Intensity Area on Optical Coherence Tomography After Drug-Eluting Stents Implantation Eui Im et al TCT-274. Relationship Between Arterial Remodeling, Fibrous Cap Thinning and Lipid Accumulation: A Serial Integrated Backscatter Intravascular Ultrasound and Optical Coherence Tomography Study Teruyoshi Kume et al TCT-275. The Evolution of Thin-Capped Fibroatheroma in Left Main Coronary Artery As Assessed by Serial Virtual Histology Intravascular Ultrasound Analysis Sang-Wook Kim et al TCT-276. Culprit Lesion Phenotype May Depend on Lesion Location in Patients with ST-Elevation Acute Myocardial Infarction: TAMI-R Study Sang-Wook Kim et al TCT-277. High Level of Copeptin in ST- Elevation Acute Myocardial Infarction Patients Is Associated with In-Hospital Mortality and Plaque Rupture: TAMI-COP Study JeeEun Kwon et al TCT-278. Two-Year Clinical Impact of Postprocedural Incomplete Stent Apposition and Late Acquired Incomplete Stent Apposition After Deployment of Zotarolimus Eluting Stent or Everolimus Eluting Stent Sang-Rok Lee et al TCT-279. Characterization of Plaque Removed by Rotational Atherectomy Paula Mota et al TCT-280. Acute and Long-term Prognostic Impact of Attenuated Plaque in Patients with Acute Coronary Syndrome Hiroyuki Okura et al TCT-281. The Association Between Cholesterol Crystal and Features of Plaque Vulnerability on Optical Coherence Tomography Yu Kataoka et al TCT-282. The REMEDEE OCT Study: A Prospective Randomized Study of the Early Vascular Healing of a Novel Dual Therapy Stent in Comparison with an Everolimus- Eluting Stent Ulf Landmesser et al TCT-283. Intimal Hyperplasia and Vascular Remodeling After Everolimus-Eluting and Sirolimus-Eluting Stent Implantation in Diabetic Patients: The Randomized Diabetes and Drug-Eluting Stent (DiabeDES) IV Intravascular Ultrasound Trial Lisbeth Antonsen et al TCT-284. Significant Correlation Between Coronary and Carotid Atherosclerotic Plaque Components by Intravascular Ultrasound Virtual Histology in Patients with Generalized Atherosclerosis Dace Sondore et al TCT-285. Frequency and Type of Neoatherosclerosis Five Years After Drug-Eluting Stent Implantation: An Optical Coherence Tomography Study Masanori Taniwaki et al TCT-286. Characteristics of OCT Findings for Lesions Avoiding Onset of AMI Hiroshi Ishimori et al 88

91 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics TCT-288. Impact of the Prevalence of Diabetes Mellitus on Coronary Plaque Vulnerability Assessed by Integrated Backscatter Intravascular Ultrasound Iwata Atsushi et al TCT-289. Clinical Feasibility of Higher- Frequency IVUS for Quantitative Measurements of Native Coronary Lesions: First-in-Human Experience with 60 MHz vs. 40 MHz IVUS Imaging Ching-Chang Huang et al TCT-290. Vascular Tissue Reaction to Acute Malapposition in Human Coronary Arteries: Sequential Assessment with Optical Coherence Tomography Juan Luis Gutiérrez-Chico et al TCT-291. Detection of Thin and Thick Fibrous Caps Overlying Lipid Core Coronary Plaques with a Catheter-Based Near-Infrared Spectroscopy System Sean Madden et al TCT-292. Evaluation of Neointimal Healing and Late Luminal Loss of Endothelial Progenitor Cell Capturing Sirolimus-Eluting (COMBO) Stent by Optical Coherence Tomography: The EGO-COMBO Study Stephen Wai Luen Lee et al TCT-293. Neointimal Tissue Characteristics Based on Optical Coherence Tomography Analysis Following Paclitaxel Coated Balloon Treatment in a Porcine Iliofemoral Vascular Territory Maxwell E. Afari et al TCT-294. Temporal Course of Vessel Healing After Everolimus-Eluting Stent Implantation Hiromasa Otake et al TCT-295. Neointimal Growth Pafter Between Biodegradable Polymer Biolimus-Eluting or Permanent Polymer Everolimus-Eluting Stent Implantation Assessed with Newly Developed Spread Out Neointimal Topography: Results from ISAR-TEST 6 OCT Trial Tomohisa Tada et al TCT-296. Comparison of Zotarolimus-Eluting Stents vs. Everolimus-Eluting Stents vs. Sirolimus-Eluting and in Patients with Long Coronary Artery Lesions Assessed by Volumetric Intravascular Ultrasound Analysis Young-Rak Cho et al TCT-297. Stent Edge Dissections Detected by Optical Coherence Tomography, Incidence, Predictors, and 12-Month Outcomes Rasmus D. Christensen et al TCT-300. Differential Prognostic Impact of Intravascular Ultrasound Utilization According to Implanted Stent Length Jeong Yoon Jang et al TCT-301. Feasibility and Results of Novel Side Branch Evaluation by Reconstructed 3-D Optical Coherence Tomography: Matched Analysis of Baseline and 12-Month Follow-up in Native, Jailed, and Opened Side Branches Niels R. Holm et al TCT-302. Evaluation of the Novel DESolve Myolimus-Eluting Bioresorbable Coronary Scaffold System for Treatment of De Novo Coronary Arteries: Six-Month Optical Coherence Tomography Results from the DESolve FIM Trial Daniel Chamié et al TCT-303. Predictors of Acute and Late Persistent Stent Malapposition After Percutaneous Coronary Intervention: A Follow-up Optical Coherence Tomography Study Eui Im et al TCT-304. Neoatherosclerosis and Impaired Vascular Healing Are Associated with Clinical Presentation Late After Coronary Stent Implantation: An Optical Coherence Tomography Study Antonios Karanasos et al TCT-305. Correlation Between Predicted to Observed Coronary Drug-Eluting Stent (DES) Expansion as Determined by Intravascular Ultrasound (IVUS): Variance Between Stent Platforms and Impact of Lesion Characteristics Sandeep Nathan et al TCT-306. Intravascular Ultrasound Findings in Complex Coronary Bifurcation Lesions Treated with Single Stenting vs. Double Stenting Strategies Ricardo A. Costa et al TCT-307. Comparison of Optical Coherence Tomography and Intravascular Ultrasound Imaging for Left Main Stenting Thibault Lhermusier et al TCT-308. Intravascular Ultrasound-Guided Everolimus-Eluting Stent Implantation Resolves the Disadvantage of Thin-Strut Cobalt Chromium Platform in Diabetes: Comparison of Three Different Type Platform Stents Hachidai Takahashi et al TCT-309. Correlation Between Fractional Flow Reserve and Intravascular Ultrasound in Patients with Isolated Ambiguous Left Main Stenosis Jacek Legutko et al TCT-310. Plaque Neovascularization Correlates with Thermal Heterogeneity as Measured by Microwave Radiometry Konstantinos Toutouzas et al TCT-311. Rate of Plaque Negative to Plaque Positive Conversion in Patients by Serial 64-Slice Computed Tomography Coronary Angiography (CTCA) Laurn Contreras et al TCT-312. Coronary Plaque Regression by 64-Slice Computed Tomography Coronary Angiography (CTCA): Pipe Dream or Real Possibility Laurn Contreras et al TCT-313. Incidence and Morphologic Characteristics of Plaques That Evolve into Culprit Lesions: A Coronary CT Angiography Natural History Study James L. Smith et al Left Main Stenting TCT-693. Impact of the Syntax Score on the Outcome of the Left Main After Drug-Eluting Stent Implantation Klaus Tiroch et al TCT-694. Clinical and Angiographical Outcomes of Percutaneous Coronary Intervention with Triple Kissing Balloon Technique After Drug-Eluting Stent Implantation for Left Main Trifurcation Disease Shunsuke Kubo et al TCT-695. Single vs. Double Stenting for the Left Main Coronary Bifurcation: A Systematic Review and Meta-Analysis Wassef Karrowni et al TCT-696. Impact of Bifurcation Angle on Major Cardiac Events After Cross Over Single Stent Strategy In Unprotected Left Main Bifurcation Lesion: 3-D Quantitative Coronary Angiographic Analysis Kisaki Amemiya et al TCT-697. Provisional Side Branch Stenting for Distal Left Main Percutaneous Coronary Intervention Thierry Lefèvre et al TCT-699. Comparison of Transradial Coronary Intervention vs. Coronary Artery Bypass Grafting for Unprotected Left Main Disease in Patients with Acute Coronary Syndrome Yu Jie Zhou et al TCT-700. A Systematic Review and Metaanalysis of Ostial and Trunk vs. Distal Lesions in Unprotected Left Main Coronary Artery Stenting Wassef Karrowni et al TCT-701. Two-Year Outcomes Following Unprotected Left Main Stenting with First- vs. New-Generation Drug-Eluting Stents: The FINE Registry Gill L. Buchanan et al Tuesday - October 23,

92 Tuesday, October 23 TCT-702. The Impact of Pre- and Post- Dilatation on Stent Deformity After Single Stenting and Kissing Balloon Technique in a Large Left Main Bifurcation Model: Insights from In Vitro Bench Testing Takenori Domei et al TCT-703. Comparison of Five-Years Clinical Outcome of Drug-Eluting Stent Implantation in High-Angled Bifurcation and Narrow- Angled Bifurcation Lesion of Unprotected Left Main Coronary Arteries Sunao Nakamura et al TCT-704. Short- and Long-term Clinical Outcomes of Left Main Treatment with a Latest Generation Drug-Eluting Stent Bernard Chevalier et al TCT-705. A Comparison of Clinical Outcomes in Patients with Left Main Disease Treated with CABG vs Drug-Eluting Stents: A Single-Center Experience Daniel A. Zanuttini et al TCT-706. Dedicated Bifurcation Optimization Stent System BiOSS in Distal Left Main Bifurcation Stenosis: First-in-Human Results: Data from BIOSS Registry (Poland and Bulgaria) Alexander Alexandrov et al TCT-707. Drug-Eluting Stents for the Treatment of Left Main Coronary Artery Disease with Bifurcated Lesions: A Comparison with Sirolimus, Paclitaxel, Zotarolimus (Endeavor Resolute), Biolimus A9, EPC Capture, and Everolimus-Eluting Stent: Multicenter Registry in Asia Sunao Nakamura et al TCT-708. Long-term Effectiveness and Safety of Triple vs. Dual Antiplatelet Therapy After Percutaneous Coronary Intervention for Unprotected Left Main Coronary Artery Disease Hyun Jong Lee et al TCT-709. Predictors of Main Branch Restenosis Following Drug-Eluting Stent Implantation in Patients with De Novo Unprotected Distal Left Main Bifurcation Coronary Lesions: The MIlan and New- TOkyo (MITO) Registry Kensuke Takagi et al TCT-710. Prognostic Impact of Left Main Coronary Artery Revascularization in Multivessel Coronary Artery Disease Jung-Min Ahn et al Mitral Valve Disease and Intervention TCT-779. Acute Severe Mitral Regurgitation Following Balloon Mitral Valvotomy: Echocardiographic Features, Operative Findings, and Outcome in 50 Surgical Cases Manjunath C. Nanjappa et al TCT-780. Baseline Systolic Left Ventricular Function Determines Hemodynamic Adaptation Following Percutaneous Mitral Valve Repair: Assessment by Conductance Catheter Volker Rudolph et al TCT-781. Concept of the Central Clip: When to Use One or Two MitraClips Eduardo Alegria et al TCT-782. Immediate Reduction of RT3D Color Doppler Vena Contracta Area After Transcatheter Mitral Leaflet Repair: Influence of the EVEREST Criteria Bjoern Plicht et al TCT-783. Successful MitraClip Therapy in Elderly Patients Not Amenable to Surgery: Serial Assessment of Echocardiographic and Clinical Variables Out to Two Years Michael Schlueter et al TCT-784. Prognostic Implications of Moderate and Severe Mitral Regurgitation in Contemporary Clinical Care Ajay Sinhal et al TCT-785. Single-Center Experience in Transcatheter Paravalvular Leak Closure: Procedural Success and Long-term Follow-up Reda Ibrahim et al TCT-786. Cost-effectiveness of the MitraClip Compared with Mitral Valve Surgery: 12-Month Results from the EVEREST II Randomized Controlled Trial Matthew R. Reynolds et al TCT-787. Effectiveness of Transcatheter Mitral Valve Repair in Degenerative Mitral Regurgitation in High Surgical Risk Patients D. Scott Lim et al TCT-788. The EVEREST II Randomized Controlled Trial (RCT): Three-Year Outcomes Ted Feldman et al TCT-789. Optimizing Plugs Size for Transcatheter Paravalvular Leak Closure with Amplatzer Vascular Plug III Devices Piotr Pysz et al TCT-790. Prediction of Long-term Clinical Outcome According to the Etiology of Mitral Regurgitation in Patients Undergoing MitraClip Therapy Volker Rudolph et al TCT-791. Percutaneous or Surgical Repair for Functional Mitral Regurgitation: Comparison of Patient Characteristics and Clinical Outcomes Lenard Conradi et al TCT-792. Mitral Inflow Patterns at Rest and During Exercise Following MitraClip Implantation Kirsten Boerlage-van Dijk et al TCT-793. Effects of Preoperative Tricuspid Regurgitation on Mitral Regurgitation Treatment with the MitraClip Device in High-Risk Patients Maurizio Taramasso et al TCT-794. Percutaneous Closure of Paravalvular Mitral Prosthetic Regurgitation with AVPIII Device Eulogio J. Garcia et al TCT-795. Procedural Success Is Improved with a Second MitraClip Placement Without Additional Complications Takashi Matsumoto et al TCT-796. The MitraClip Procedure for Functional Mitral Regurgitation Results in a Significant Change in Procedural Hemodynamics Wen Loong Yeow et al TCT-797. Transcatheter Mitral Valve-in-Valve/ Valve-in-Ring Implantations for Degenerative Post-Surgical Valves: Results from the Global Valve-in-Valve Registry Danny Dvir et al TCT-798. The 3C-HF as a New Predictor of Outcomes After MitraClip Francesco Maisano et al TCT-799. MitraClip Feasibility and Efficacy in the Contest of Unfavorable Valve Anatomy Nicola Buzzatti et al Peripheral Vascular Disease and Intervention TCT-151. Endovascular Intervention in Patients with Critical Limb Ischemia in Taiwan: Patient Outcomes in 333 Consecutive Limb Procedures with a Six-Year Follow-up Hsuan Li Huang et al TCT-152. Impact of Body Surface Area on Outcomes in Patients with Lower Extremity Peripheral Arterial Disease Alix J. Tercius et al TCT-153. Renal Artery Aneurysms: First Human Treatment with the Multilayer Flow Modulator Michel C. Henry et al TCT-154. The Multilayer Flow Modulator Stent for the Treatment of Popliteal Aneurysm Michel C. Henry et al 90

93 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics TCT-155. A New Concept of Stent: The Multilayer Flow Modulator: First Human Study In Peripheral and Visceral Aneurysms Michel C. Henry et al TCT-156. Renal Angioplasty and Stenting: Limitations and Role of Embolic Protection Devices Isabelle Henry et al TCT-157. Increased Local Cytokine Production at Culprit Superficial Femoral Artery Plaques Cameron Donaldson et al TCT-158. Impact of Subclinical Peripheral Arterial Disease Severity on Middle and Long-term Outcomes in Patients with ST-Elevation-Myocardial Infarction Daniel E. Monopoli et al TCT-159. Effects of PRT-201, a Recombinant Human Type I Pancreatic Elastase, Treatment on the Elastin Content and Compliance of Atherosclerotic Tibial Arteries Following Ex Vivo Angioplasty Steven K. Burke et al TCT-160. Effects of PRT-201, a Recombinant Human Type I Pancreatic Elastase, Treatment on the Elastin Content and Compliance of Atherosclerotic Tibial Arteries Using a Perfusion Myograph Steven K. Burke et al TCT-161. Long-term Effect of Transcatheter Intraarterial Administration of Bone Marrow Mononuclear Cells in Patients with Critical Limb Ischemia Jean-Claude M. Lubanda et al TCT-162. Distal Embolization and Protective Devices: Mortality, Operating Room Time, Length of Stay, and Costs Eric J. Dippel et al TCT-163. Drug-Eluting Balloon for Below-the- Knee Angioplasty: One-Year Results from a Single-Center DEB-BTK Registry Grigore Popusoi et al TCT-164. Below-the-Knee Drug-Eluting Stents Have Improved Patency, and Symptoms Compared to Bare Metal Stents: A Meta-analysis Alexandre M. Benjo et al TCT-165. Evaluation of Long-term Vascular Responses to Fluorocopolymer coated Self-Expanding Low-Dose Paclitaxel-Eluting Stent in Porcine Iliofemoral Model Dongming Hou et al TCT-166. Association Between Leg Wound Site and Prognosis of Hemodialysis Patients with Critical Limb Ischemia After Isolated Infrapopliteal Balloon Angioplasty Masatsugu Nakano et al TCT-167. Clinical and Angiographic Outcome About External Iliac Artery: Internal Iliac Artery Bifurcation Lesion Which Jailed IIA Comparison Between Crossover Stenting Strategy and Noncrossover Stenting Takuro Takama et al TCT-168. Patency Rates of Intraluminal vs. Device Assisted Subintimal Endovascular Revascularization of the Chronic Total Occlusion in the Superficial Femoral Artery Anvar Babaev et al TCT-169. E-MISAGO: The Largest Ongoing Real Life Registry of Misago SX Nitinol Stent in Daily Use: Clinical Outcome at One Year Johannes Ruef et al TCT-170. Vascular Injury Influences Drug Transfer and Vessel Healing Following Paclitaxel-Coated Balloon Delivery in the Peripheral Arteries of Swine Maxwell E. Afari et al TCT-171. Paclitaxel Balloon Delivery Results in Homogeneous In-Stent Neointimal Distribution and Reduction of Stent Edge Stenosis Progression in the Peripheral Swine Model Maxwell E. Afari et al TCT-172. Drug-Coated Balloon for Peripheral Arteries: Results from Preclinical Experiments Using the Freeway DCB Rembert Pogge Von Strandmann et al TCT-173. Bare-Nitinol Stent vs. Paclitaxel- Coated Balloon for Femoropopliteal Revascularization: An Adjusted Indirect Comparison Meta-analysis of Randomized Trials Salvatore Cassese et al TCT-174. EPIC Nitinol Stent Treatment of Iliac Artery Lesions: 12-Month Outcomes in the ORION Study Daniel Clair et al TCT-175. Optimal Antiplatelet Regimen for Critical Limb Ischemia Due to Pure Isolated Infrapopliteal Lesions Junichi Tazaki et al TCT-176. Recanalization of Infrapopliteal Chronic Total Occlusions in Critical Limb Ischemia Gagan D. Singh et al TCT-177. Controlled Paclitaxel Delivery to the Peripheral Vasculature with the TAPAS Drug Delivery System Mehdi Shishehbor et al TCT-178. Impact of Varying Injury Severity and Multiple Treatments on Arterial Histopathology Early After Paclitaxel-Coated Balloon Treatment of the Iliofemoral Arteries of Domestic Swine Maxwell E. Afari et al TCT-179. Procedural and Clinical Outcomes After Endovascular Intervention for Femoral-Tibial Graft Stenosis Christopher Balwanz et al TCT-180. Mid-term Outcomes Following Endovascular Intervention for Iliac Artery In-Stent Restenosis Usman Javed et al TCT-181. Totally Occluded In-Stent Restenosis After Superficial Femoral Artery Stenting Does Not Worsen the Long-term Outcomes but Tend to Recur Occlusively Sanghoon Shin et al TCT-182. Angioplasty of the Hand Arteries in Critical Hand Ischaemia Zoltán Ruzsa et al TCT-183. Acute Outcomes for a Below-the- Knee Use of a Novel Balloon Catheter: First-in-Man Clinical Study Dierk Scheinert et al TCT-184. Subintimal Angioplasty or Bypass Surgery in CLI Patients with TASC II Type C/D Lesions: Mid- to Long-term Clinical Outcomes Niamh Hynes et al TCT-185. Association Between the Ankle- Brachial Index and the Severity of Coronary Artery Disease Yong Kyu Park et al TCT-186. Relationship Between Improvement of Skin Perfusion Pressure, Clinical Outcomes, and Wound Blush After Successful Endovascular Treatment Makoto Utsunomiya et al TCT-187. Factors of Restenosis After Endovascular Treatment for Iliac Artery Hideyuki Takimura et al TCT-188. Efficacy of the Novel Ultrasonography Vascular Elastography Guided Endovascular Therapy Hideyuki Takimura et al TCT-189. Plaque Excision as a Treatment Option for Popliteal Atherosclerotic Disease: One-Year Results from the DEFINITIVE LE Study James McKinsey et al PFO, ASD, and Congenital Heart Disease TCT-770. Transcatheter Device Closure of Atrial Septal Defect In Infants and Young Children Edwin Francis et al Tuesday - October 23,

94 Tuesday, October 23 TCT-771. Long-term Results of a Comparison of Three Patent Foramen Ovale Closure Devices in a Randomized Trial (Amplatzer vs. CardioSEAL, STARflex vs. Helex Occluder) Marius Hornung et al TCT-772. Role Of Non-ECG Gated Contrast CT in Preventing Percutaneous Pulmonary Valve Implantation-Related Coronary Compromise Oliver J. Monfredi et al TCT-773. Transcatheter Closure of Perimembranous Ventricular Septal Defect with the Amplatzer Membranous VSD Occluder 2 Apostolos Tzikas et al TCT-774. Ten-Year Experience with Transcatheter Closure of Perimembranous Ventricular Septal Defects Using the Amplatzer Asymmetric Perimembranous Ventricular Septal Defect Occluder in Children Vasileios Thanopoulos et al TCT-775. Novel System for Detection of Cardiac Right to Left Shunts Robert Sommer et al TCT-776. UNES (Utah Nickel Elution Studies) Anwar Tandar et al TCT-777. Non-Cerebrovascular Systemic Arterial Embolic Events from Paradoxical Embolization via Patent Foramen Ovale Ronan J. Margey et al TCT-778. Long-term Outcomes After Transcatheter Closure of Patent Foramen Ovale Sammy Elmariah et al Physiologic Assessment TCT-218. Evaluating Ischemia in the Myocardium of a Chronic Total Occlusion to Determine the Value of Percutaneous Recanalization Rajesh Sachdeva et al TCT-219. Evaluating Ischemia of an Intermediate Stenosis in a Donor Artery During Recanalization of a Chronic Total Occlusion Rajesh Sachdeva et al TCT-220. The Impact of the Supply Area on the Fractional Flow Reserve Value in Stable Coronary Artery Disease Yasutsugu Shiono et al TCT-221. Diagnostic Performance of Intracoronary Gradient-Based Methods by Coronary Computed Tomographic Angiography for the Evaluation of Physiologically Significant Coronary Artery Stenoses: A Validation Study with FFR Jin-Ho Choi et al TCT-222. Combining Parameters of Coronary Angiography and Intracoronary Pressure Measurement Predicts More Preciously the Severity of the Ischemia on the Myocardial Perfusion Scintigraphy Than the Fractional Flow Reserve Alone Zsolt Köszegi et al TCT-223. Instantaneous Fractional Flow Reserve: Conceptual Implications for Myocardial Perfusion Imaging David Barmby et al TCT-224. Long-term Clinical Outcomes of Medical Therapy vs. Coronary Revascularisation in Patients with Intermediate Stenoses Guided by Pressure Wire Hongyu Shi et al TCT-225. The Role of Collateral Pressure Index Assessing Collateral Function and Coronary Hemodynamics in Patients with Total or Nearly Total Occluded Coronary Lesions Jang Hoon Lee et al TCT-226. Comparison of Endothelial Function in the Left Main Coronary Artery and Epicardial Arterial Segments Rishi Puri et al TCT-227. Outcomes of Deferred FFR-Negative Stenoses: Real-world Experience in a Community-Based Cardiac Referral Center Michael Ho et al TCT-228. Coronary Endothelial Dysfunction Predicts Long-term Prognosis in Patients With Successful First-Generation Drug- Eluting Stents Implantation Without Residual Stenosis at Chronic Stage Shigenori Ito et al TCT-229. The Safety and Feasibility of Nicorandil Compared to Adenosine Triphosphate as Hyperemic Agents for Fractional Flow Reserve Measurements Daiki Kato et al TCT-230. Instantaneous Wave-Free Ratio (ifr) and Gradient (ifg): New Promising Adenosine-Independent Alternative to Fractional Flow Reserve: Preliminary Results from the FORECAST Study Salvatore De Rosa et al TCT-231. Investigation of Fractional Flow Reserve Correlation with Direct Anatomical Parameters Using a Percutaneous Model of Coronary Artery Stenosis Ricardo Petraco et al TCT-232. Left Ventricular Filling Pressures Affect Measurements of Fractional Flow Reserve Robert A. Leonardi et al TCT-234. Prediction of Fractional Flow Reserve Using Contrast Media Flow Data Under Vasodilatation and the Parameters of 3-D Coronary Angiography Zsolt Köszegi et al TCT-235. Accuracy of 320 Computed Tomography Coronary Angiography in Detection of Functionally Significant Stenoses: Comparison with FFR Brian Ko et al TCT-236. The Diastolic Wave-Free Period Is the Most Suitable Period in the Cardiac Cycle for the Assessment of a Coronary Stenosis: Implications for the Accurate Calculation of the Instantaneous Wave-Free Ratio (ifr) Sayan Sen et al TCT-237. Fractional Flow Reserve vs. Angiographic Guidance of Percutaneous Coronary Intervention: A Systematic Review and Meta-analysis Jung-Min Ahn et al TCT-238. The Instantaneous Wave-Free Ratio (ifr) and Fractional Flow Reserve (FFR) Have Equivalent Diagnostic Categorisation When Compared to Flow Based Indices Sayan Sen et al TCT-239. Does Adenosine Administration Improve Diagnostic Classification of the Instantaneous Wave-Free Ratio (ifr)? Sayan Sen et al TCT-240. Benefits and Costs of Routine Fractional Flow Reserve Assessment in All Major Epicardial Vessels During Elective Invasive Angiography Brian Ko et al Pulmonary Thromboembolism and Hypertension and Tricuspid Disease TCT-754. Efficacy and Safety of Balloon Pulmonary Angioplasty for Peripheral Type Chronic Thromboembolic Pulmonary Hypertension. Yu Taniguchi et al TCT-755. Beneficial Vascular Remodeling and Hemodynamic Improvement following Balloon Pulmonary Angioplasty for Chronic Thromboembolic Pulmonary Hypertension Hiroto Kinutani et al TCT-756. Role of Trellis Catheter in the Treatment of IVC Filter Thrombosis Mohsen Sharifi et al TCT-757. Rapid Resolution of Right Ventricular Dysfunction Using Ultrasonic Thrombolysis in Massive and Submassive Pulmonary Embolism Patients Tod C. Engelhardt et al 92

95 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics TCT-758. Percutaneous Thrombectomy with Right Coronary Judkins 8-Fr Guide Catheter for the Treatment of High-Risk Acute Pulmonary Embolism Jose Luis Ojeda Delgado et al TCT-759. Ultrasound-Accelerated Thrombolysis for the Treatment of Acute Pulmonary Embolism Matthew E. Wiisanen et al Renal Denervation TCT-204. Impact of Temperature, Energy Output and Impedance Drop During Renal Denervation on the Long-term Outcome Klaus Tiroch et al TCT-205. Histologic Analysis of Renal Nerve Injury Following Catheter-Based Renal Denervation in Obese Hypertensive Canines Jeffrey R. Henegar et al TCT-206. A Pilot Study on Renal Sympathetic Denervation for Resistant Hypertension in the West of Ireland Imtiaz A. Kalyar et al TCT-207. Beta Radiation for Renal Nerve Denervation: Initial Feasibility and Safety Ron Waksman et al TCT-208. Catheter-Based Renal Sympathetic Denervation: Results of the Heidelberg Registry Michael Kirchberger et al TCT-209. Durable Reduction in Blood Pressure in the First Cohort of Patients Treated with Renal Sympathetic Denervation Therapy for Resistant Hypertension Sonny Palmer et al TCT-210. Decrease of the Norepinephrine Release from Sympathetic Nerves During Renal Denervation Klaus Tiroch et al TCT-211. Ambulatory Blood Pressure and Dipping-Pattern After Catheter-Based Renal Sympathetic Denervation in Patients with Resistant Hypertension Felix Mahfoud et al TCT-212. First Report of the Six-Month First-in-Human Results of the OneShot Renal Denervation System: The RHAS Study John A. Ormiston et al TCT-213. Safety and Efficacy of a Novel Multielectrode Renal Denervation Catheter in Resistant Hypertension: Three-Month Data from the EnligHTN I Trial Stephen G. Worthley et al TCT-215. Effect of Renal Denervation Therapy on Blood Pressure and Pulse Pressure in Young Compared to Old Patients Tobias Graf et al TCT-216. A Preclinical Comparative Histological Evaluation of the Renal Artery and Nerves in the Human Cadaver and Swine Model Radhika R. Tunstall et al TCT-217. Pathologic Insight into Nerve Injury in Swine Treated with Ultrasound Renal Artery Denervation System Addisalem Taye Makuria et al Statins, Beta-blockers, and Other Pharmacologic Agents TCT-711. Nicorandil Prevents Microvascular Dysfunction Resulting from Percutaneous Coronary Intervention in Patients with Stable Angina Pectoris Atsushi Hirohata et al TCT-712. Can Amelioration of HDL-C Level by Pitavastatin Improve Clinical Outcomes in Acute Myocardial Infarction Patients Undergoing Percutaneous Coronary Intervention? Seung-Woon Rha et al TCT-713. The Benefit of Beta-blocker Therapy in Hospital Survivors Receiving Primary Percutaneous Coronary Intervention After ST-Elevation Myocardial Infarction from the Korea Acute Myocardial Infarction Registry Jang Hoon Lee et al TCT-714. A Meta-Analysis of Randomized Controlled Trials Appraising The Efficacy and Safety of New Oral Antithrombotics in Patients with Acute Coronary Syndrome Kyu-Nam Choi et al TCT-715. First Demonstration of Dose Dependent Effect of Statin Therapy on Urinary 11-Dehydrothromboxane B2 Levels in Patients Undergoing Coronary Angiography Paul A. Gurbel et al TCT-717. Impact of Antianginal Therapy and Rate Pressure Product Control on the Need for Repeat Revascularization Post-PCI Subhash Banerjee et al TCT-718. Statin Is More Effective in Acute Myocardial Infarction Patients in Atrial Fibrillation with High Level of High Sensitivity C-Reactive Protein Than Those with Low Level Hae Chang Jeong et al TCT-719. Effects of Ranolazine in Patients with Acute Coronary Syndrome and Stable Angina According to Whether They Undergo Percutaneous Coronary Intervention: Observations from the MERLIN-TIMI 36 Trial Benjamin M. Scirica et al STEMI and NSTEMI TCT-457. The Use of a Dedicated Coronary Bifurcation Stent in Patients Presenting with Myocardial Infarction Maik J. Grundeken et al TCT-458. Late Outcomes of Patients with Myocardial Infarction Undergoing Drug- Eluting Stent Implantation in Daily Clinical Practice Ricardo A. Costa et al TCT-459. Long-term Outcome in Patients with ST-Elevation Myocardial Infarction and Infarct-Related Coronary Artery Ectasia treated with Primary Percutaneous Coronary Intervention Gian Battista Danzi et al TCT-460. Comparison of Safety and Efficacy Between Transradial Intervention (TRI) and Transfemoral Intervention (TFI) in Acute Myocardial Infarction: Result from KORMI Registry Data Byung-Hyun Joe et al TCT-462. Invasive Strategies and Outcomes for Non-ST-Segment Elevation Acute Coronary Syndromes: A 12-Year Experience from SWEDEHEART Peter Damman et al TCT-463. In-Hospital Mortality Following Primary Angioplasty in the Setting of Cardiac Arrest Is High and Varies Depending on Patient Location at the Time of Arrest: A UK Registry Database Study Vijay Kunadian et al TCT-464. The Killip Classification Is Still Useful in Current Practice? An Analysis of 4,342 Patients in the Regional Acute Myocardial Infarction Registry of Brittany (ORBI) Marc Bedossa et al TCT-465. Prevalence, Correlation, and Clinical Outcome of Intraprocedural Stent Thrombosis in Patients Undergoing Primary Percutaneous Coronary Intervention for Acute Coronary Syndrome Yingjia Xu et al TCT-466. Clinical impact of the Use of Thrombus Aspiration Devices in Primary Angioplasty: Insights from the Multicentric Study ESTROFA-MI Jose M. De La Torre Hernandez et al TCT-467. Clinical Outcomes After Anterior ST-Elevation Myocardial Infarction According to LAD Lesion Location: The INFUSE-AMI Trial Sorin Brener et al Tuesday - October 23,

96 Tuesday, October 23 TCT-468. Impact of Successful Thrombus Retrieval During Primary Percutaneous Coronary Intervention with Thrombus Aspiration on Infarct Size and Microvascular Obstruction: Insight from Contrast-Enhanced Magnetic Resonance Imaging Romain Chopard et al TCT-469. Frequency, Timing, and Implications of Reinfarction After Primary Stenting in ST-Segment Elevation Myocardial Infarction: The HORIZONS-AMI Trial Samantha Stone et al TCT-470. Manual Thrombectomy During Primary Percutaneous Coronary Intervention Can Preserve the Index of Microcirculatory Resistance in Patients with Anterior ST-Segment Elevation Myocardial Infarction Seong Ill Woo et al TCT-471. The Impact of First- vs. Second- Generation Drug-Eluting Stents on Immediate- and Intermediate-term Outcomes in a Complex ST-Segment Elevation Myocardial Infarction Population Joshua P. Loh et al TCT-472. Prognosis of Patients Presenting with Non ST-Segment Elevation Myocardial Infarction and Nonobstructive Coronary Artery Disease: Propensity Score Matched Cohort from the ACUITY Trial David Planer et al TCT-473. Admission at Nights or Weekends Has No Adverse Effect on Mortality for ST-Elevation Myocardial Infarction Patients Treated by Primary Percutaneous Coronary Intervention: Single-Center Study from a Large Tertiary Cardiac Unit In United Kingdom Refai Showkathali et al TCT-474. Paclitaxel-Eluting Balloon in Primary Percutaneous Coronary Intervention in Amsterdam (PAPPA): Sustained Safety and Efficacy at 12-Months Follow-up Nicola S. Vos et al TCT-475. Association of the P53 Codon 72 Polymorphism with Infarct Size and Left Ventricular Ejection Fraction in Patients with ST-Segment Elevation Acute Coronary Syndrome Juan Carlos Rama Merchan et al TCT-476. Relationship Between Reference Vessel Diameter and the Incidence and Impact of Incomplete Coronary Revascularization Following PCI in ACS: The ACUITY Trial Gregg Rosner et al TCT-477. The Reperfused Myocardial Infarct Core Shows Extensive Hemorrhage with Loss of Vascular Integrity: A Comparison of Findings from Cardiovascular Magnetic Resonance Imaging with Histology Lourens Robbers et al TCT-478. Comparison of Leaman Weighing Factor and Individualized Coronary Angiographic Area at Risk Assessment with Autopsy Findings Zsolt Köszegi et al TCT-479. Impact of Left Ventricular Dysfunction and Multi-Vessel Disease After Primary Percutaneous Coronary Intervention: Three-Year Outcomes from the HORIZONS-AMI Trial Benoit Daneault et al TCT-480. Outcomes in Patients with Nonobstructive Coronary Artery Disease With and Without Cardiac Biomarker Elevations: The ACUITY Trial Jonathan D. Newman et al TCT-481. Comparison of Newer Generation Drug-Eluting Stents with Bare Metal Stents in Patients with Acute ST-Segment Elevation Myocardial Infarction: A Pooled Analysis of EXAMINATION and COMFORTABLE AMI Trials Manel Sabate et al TCT-482. Four-Year Follow-up After One- Stage Percutaneous Coronary Intervention of Left Main Stenosis and Infarct-Related Left Anterior Descending or Circumflex Arteries in Patients with Acute Coronary Syndrom with ST-Elevation MI Evgeniy Merkulov et al TCT-483. Impact of Smoking on Outcomes of Acute Myocardial Infarction After Drug-Eluting Stent Implantation: The Smoker s Paradox Yun-Kyeong Cho et al TCT-484. Prognostic Value of Simple Standard 12-Lead Electrocardiographic Parameters for Predicting Clinical Outcomes in Hospital Survivors After Acute Myocardial Infarction Jang Hoon Lee et al TCT-485. A Simple Strategy to Significantly Reduce the Door-to-Balloon Time in Patients with Acute ST-Elevation Myocardial Infarction Alexander Joost et al TCT-486. Relationship Between White Blood Cell Count and Final Infarct Size in Patients with ST-Segment Elevation Acute Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention: Analysis from the INFUSE-AMI Trial Tullio Palmerini et al TCT-487. Door-to-Balloon Time as a Function of Mode of Referral: Results from the Ontario Provincial Cardiac Care Network Database Michel Le May et al TCT-488. Impact of Multivessel Coronary Artery Disease With or Without a Concurrent Chronic Total Occlusion on Survival in Patients Treated with Rescue Angioplasty Francesco De Felice et al TCT-489. Stent Thrombosis After Primary PCI for STEMI in Relation to Nonusage of Dual Antiplatelet Therapy Over Time: Results of the HORIZONS-AMI Trial Bimmer Claessen et al TCT-490. Coronary Artery Disease and Tako-tsubo Cardiomyopathy: A Possible Association Guido Parodi et al TCT-491. Incidence and Predictors of 30-Day Mortality in Elderly Patients with ST-Segment Elevation Acute Myocardial Infarction Undergoing Primary Angioplasty Antonio Alejandro De Miguel Castro et al TCT-492. Impact of Vessel Size on Angiographic and Clinical Outcomes of Revascularization with Drug-Eluting Stent in Patients with Acute Myocardial Infarction Shin Eun Lee et al TCT-493. The Clinical Utility of High-Sensitive Troponin T to Predict Infarct Size, Left Ventricular Function, and Adverse Outcome in Patients with First ST-Elevation Myocardial Infarction Treated with Primary Percutaneous Coronary Intervention. H. Boden et al TCT-494. Impact of Level of Physician Training on Transfer of ST-Segment Elevation Myocardial Infarction Edward O Leary et al TCT-495. Percutaneous, Transendocardial Injection of Bone Marrow Derived Mononuclear Cells Significantly Improves Left Ventricular Ejection Fraction in Patients Following Acute Myocardial Infarction: ALSTER Stem Cell Trial Christian Heeger et al TCT-496. Physician s Procedure Volume and Not Years of Experience, Determine Needle-to-Balloon Time in Primary Percutaneous Coronary Intervention Imdad Ahmed et al TCT-497. ST-Segment Elevation Acute Myocardial Infarctions Diagnosed by the Emergency Department: Impact on False Positive Calls and Door-To-Balloon Time Tudor Vagaonescu et al 94

97 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics TCT-498. Chronic Myocardial Tissue Effects of Intracoronary Supersaturated Oxygen in a Porcine Model of Anterior Myocardial Infarction Greg L. Kaluza et al TCT-499. Prediction of Lesion Type-Related MACE by sflt-1 and GDF-15: Results from The PROSPECT Study Martin Mockel et al TCT-500. Silent Occlusion but Not Restenosis Without Occlusion After Primary Percutaneous Intervention Strongly Predicts Both Deterioration of Cardiac Function and Future Clinical Events Shinichiro Yamada et al TCT-501. Impact of Adjunctive Thrombectomy on Myocardial Perfusion in Patients Undergoing Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction: An Updated Meta-analysis Jae-Sik Jang et al TCT-502. Small vs. Large Culprit Vessel Size in Primary Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction: Incidence, Clinical Characteristics and Outcome Differences Refai Showkathali et al TCT-503. Predictors of Longtime Survival in Acute Myocardial Infarction in Elderly Patients Harald Rittger et al TCT-504. Long-term Outcomes Among Patients with False-Positive STEMI Activations: A Report from the ACTIVATE-SF Registry Tyson Turner et al TCT-505. Prognostic Impact of Anaemia In Patients with ST-Elevation Myocardial Infarction Treated by Primary PCI Vrijraj Rathod et al TCT-506. Out-of-Hours Outcomes in STEMI Patients Treated with Primary Percutaneous Coronary Intervention Krishnaraj S. Rathod et al TCT-507. Left Bundle Branch Block Activations for Primary Percutaneous Coronary Intervention: Nonspecific Finding or a Marker for Increased Mortality? Adam J. Brown et al TCT-508. Optimal Medical Treatment in Patients with Hypertension Undergoing Primary Percutaneous Coronary Intervention for Acute Myocardial Infarction Doo Sun Sim et al TCT-509. Low Overall Rates of Angiographically Visible Distal Embolization in INFUSE-AMI: Possible Explanation for Lack of Efficacy of Manual Aspiration Thrombectomy Magdi El-Omar et al TCT-510. Impact of Insurance Status on the Mortality Outcome of Patients with ST-Elevation Myocardial Infarction Imdad Ahmed et al TCT-511. High Level of Preprocedural High-Sensitivity C-Reactive Protein Predicts Stent Thrombosis After Percutaneous Coronary Intervention in Patients with Acute Myocardial Infarction Hae Chang Jeong et al TCT-512. Echocardiographic Correlates of Persistent ST-Elevation on ECG in STEMI Patients Undergoing Percutaneous Coronary Intervention Manu Kaushik et al TCT-513. Simple Measures of ST-Segment Resolution Predict Infarct Size: The INFUSE-AMI Trial Joe Dizon et al TCT-514. Intracoronary Infusion of Mononuclear Cells Compared with Standard Therapy After Acute Myocardial Infarction: Two-Year Magnetic Resonance Imaging Results of the Randomized Controlled Hebe Trial Ronak Delewi et al TCT-516. Microvascular Obstruction Detected by MRI Is a Predictor of Recovery from Myocardial Stunning: The INFUSE-AMI Trial Akiko Maehara et al TCT-517. Effects of Intravenous Human Atrial Natriuretic Peptide on Left Ventricular Function In Patients with Reperfused Acute Myocardial Infarction: An Assessment by Cardiac Magnetic Resonance Imaging Takayuki Onishi et al TCT-518. Clinical Outcomes of Multiple Stent Implantation in patients with ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention Jun-Hyok Oh et al TCT-519. Randomized Study to Assess the Effect of ThRombus Aspiration on Flow Area in STEMI Patients: An Optical Frequency Domain Imaging Study (TROFI): 2-D and 3-D Analysis of Six-Month OFDI Follow-up Yoshinobu Onuma et al TCT-520. Descriptive Study of Patients with ST-Elevation Myocardial Infarction Presenting with Out-of-Hospital Cardiac Arrest Fizzah Choudry et al TCT-521. Predictors of Outcome in Patients with ST-elevation Myocardial Infarction Presenting with Out-of-Hospital Cardiac Arrest Fizzah Choudry et al TCT-522. National Trends in Case Fatality based on Anatomical Location of ST-Elevation Myocardial Infarction in Hospitalized Patients, 1993 to 2009 Abhishek J. Deshmukh et al TCT-523. Complete Coronary Occlusion of the Infarct-Related Artery in Patients Presenting with Acute Non-ST-Elevation Myocardial Infarction: Role of the GRACE Risk Score Alexander Joost et al TCT-524. Does the Zwolle Percutaneous Coronary Intervention Risk Index Identify Low Risk ST-Elevation Myocardial Infarction Patients for Early Discharge? Craig E. Strauss et al TCT-525. Reduction of Apolipoprotein B/A-I Ratio During Follow-up Predicts Lower Adverse Event Rate at One Year After Percutaneous Coronary Intervention Jae Yeong Cho et al TCT-526. Is There Sufficient Evidence to Discourage the Use of Multivessel Angioplasty During STEMI? An Analysis of 35,008 Patients Sayan Sen et al TCT-527. Contemporary Outcomes of ST-Elevation Myocardial in Patients with Prior Bypass Graft Louis Kohl et al TCT-528. Clinical Syntax Score and Long-term Outcome After Successful Primary PCI Andreas Synetos et al TCT-529. Five Types of Drug-Eluting Stents Including Zotarolimus-Eluting Stent with Biolinx Polymer Show Similar Clinical Outcomes for the Treatment of ST-Segment Elevation Myocardial Infarction Kyounghoon Lee et al TCT-530. Predictors and Clinical Outcomes Related to Door-in Door-out Times Ross Garberich et al TCT-531. Positive Predictive Value Of Clinically Suspected ST-Segment Elevation Myocardial Infarction Using Angiographic Verification Michael Maeng et al TCT-532. The Effect of Northeast Japan Earthquake on Acute Myocardial Infarction Nobuyuki Kuroiwa et al TCT-533. Impact of High-Density Lipoprotein- Cholesterol on One-Year Outcome of Patients with Acute Coronary Syndrome Undergoing PCI Yun-Kyeong Cho et al Tuesday - October 23,

98 Tuesday, October 23 Stent Fracture and Longitudinal Deformation TCT-534. Longitudinal Stent Deformation: Insights on Mechanisms, Treatments, and Outcomes from the Food and Drug Administration Manufacturer and User Facility Device Experience Database Mamas Mamas et al TCT-536. Biomechanical Assessment of the Longitudinal Compression Behavior of Drug-Eluting Coronary Stents: An In Vitro Comparative Study Régis Rieu et al TCT-538. Predictors of Stent Fracture and Impact on Neointimal Proliferation: Experimental Insights into the Mechanisms of Drug-Eluting Stent Failure Seung-Jin Oh et al TCT-539. The Longitudinal Elongation of the Contemporary Drug-Eluting Stent in a Tapered Benchtop Model Masaki Takenaka et al TCT-540. Longitudinal Drug-Eluting Stent Elongation Phenomenon Due to High Pressure Additional Dilatation: Insights from Bench Testing Takenori Domei et al TCT-541. Coronary Computerized Tomography for Systematic Screening of Coronary Stent Fractures in Patients at High Risk Lisa Krenn et al TCT-542. Axial Integrity of Coronary Stents: Evaluation Using Intravascular Ultrasound Danny Dvir et al TCT-543. Partial Strut Fracture in Everolimus- Eluting Stents: An Intravascular Ultrasound study Shinji Inaba et al TCT-544. Case Series of 100 Cases of Longitudinal Stent Deformation Doug Fraser et al TCT-545. The Impact of Sirolimus-Eluting Stent and Evelolimus-Eluting Stent on the In-Stent Restenosis and Stent Fracture: Evaluating Peri-Stent Contrast Staining Lesions After Drug-Eluting Stent Implantation Tahei Ichinohe et al Structural, Nonvalvular Intervention TCT-760. Mid-term Outcomes of Alcohol Septal Ablation for Obstructive Hypertrophic Cardiomyopathy in Patients with Sigmoid vs. Neutral Ventricular Septum Josef Veselka et al TCT-761. Complications of Alcohol Septal Ablation for Hypertrophic Obstructive Cardiomyopathy with Focus on Complete Heart Block: A European Multicenter Study Josef Veselka et al TCT-763. Impact of Left Atrial Appendage Occlusion with Percutaneous Device on Left Atrial Function Pedro M. Almeida et al TCT-764. Safety and Biocompatibility of the Coherex WaveCrest Left Atrial Appendage Occluder in a 30-Day Canine Study Yanping Cheng et al TCT-765. First In Vivo Evaluation of the Ultrasept Left Atrial Appendage Closure Device Yanping Cheng et al TCT-766. Early Safety of the Amplatzer Cardiac Plug for Left Atrial Appendage Occlusion David Meerkin et al TCT-767. Long-term Outcomes Following Percutaneous Left Atrial Appendage Closure with the Amplatzer Cardiac Plug Device in Patients with Nonvalvular Atrial Fibrillation and Contraindications for Anticoagulation Therapy Reda Ibrahim et al TCT-768. Noninvasive Cardiac Arrhythmia Therapy Using High-Intensity Focused Ultrasound (HIFU) Ablation Jing Huang et al TCT-769. Functional Performance and Structural Maturation of Decellularised Pericardial Valves in Central Venous Position: An Experimental Study Alexander Lauten et al Unusual Coronary Pathology: Spasm, Spotaneous Dissection, and Others TCT-429. Synergistic Effects of Hemoglobin, Platelet, and C-Reactive Protein in the Development of Coronary Spasm Ming-Yow Hung et al TCT-430. Myocardial Bridging Increases Diffuse and Focal Chronic Stent Recoil Following Drug-Eluting Stent Implantation Ryotaro Yamada et al TCT-431. High Prevalence of a Coronary Spasm to Ergonovine Testing in Patients with Stable Angina Pectoris and Unobstructed Coronary Arteries. Shigeru Saito et al TCT-432. Angiographic Characteristics according to Acetylcholine Dose Responsible for Significant Coronary Artery Spasm Woong Gil Choi et al TCT-433. Impact of Beta-blocker on Angiographic and Clinical Parameters During Intracoronary Acetylcholine Provocation Test Sung Il Im et al TCT-434. Implantation of Sirolimus-Eluting Stent in Patients with Vasospastic Angina Deteriorates Late Catch-up Phenomenon. Naoki Oka et al TCT-435. Spontaneous Coronary Dissection: 10 Years of Follow-up in Our Cath Lab Simone Muraglia et al TCT-436. Association of Myocardial Bridge and Acetylcholine Dose Response in Patients with Vasospastic Angina Sung Il Im et al TCT-437. The Impact of Gender Difference on Angiographic Characteristics During intracoronary Acetylcholine Provocation Test in Korean Patients Seung-Woon Rha et al TCT-438. Spontaneous Coronary Artery Dissection as a Cause of Acute Coronary Syndrome: A Case Series and Management Options Ankit Garg et al Vascular Access TCT-392. Silent Cerebral Infarcts Following Cardiac Catheterization: A Randomized Comparison of Radial and Femoral Approaches Michele Hamon et al TCT-393. A Randomized Trial Comparing Two Vascular Closure Devices: PROGLIDE and the Novel EXOSEAL After Percutaneous Femoral Procedures Madjid Hattab et al TCT-394. True Arterial Puncture Site (TAPS) Is Different from Perceived Arterial Puncture Site (PAPS) on Femoral Sheath Angiography (FSA) Zeshan Rana et al TCT-395. Ultrasound-Guided Radial Artery Access by a Nonultrasound-Trained Interventional Cardiologist Improved First-Attempt Success Rates and Shortened Time for Successful Radial Artery Cannulation Jonathan Roberts et al TCT-396. Assessment of Early Radial Injury After Transradial Coronary Intervention by High-Resolution Ultrasound Biomicroscopy: Innovative Technology Application Yujie Zhou et al 96

99 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics TCT-397. Coronary Procedures by Left vs. Right Transradial Approach in Diabetic Population Saidur R. Khan et al TCT-398. Anatomy of Femoral and Inferior Epigastric Arteries Relative to the Femoral Head by Angiography: Insights from the Femoral Arterial Access with Ultrasound Trial (FAUST) Arnold Seto et al TCT-399. Increased Radiation Exposure In Transradial Approach: A Real Drawback or a Problem? Jan Skvaril et al TCT-400. Risk of Brain Injury During Diagnostic Coronary Angiography: Comparison Between Single and Double Catheter Strategy During Right Transradial Approach Andrea Pacchioni et al TCT-401. A Comprehensive Easily Applicable Approach to Graduation of Radial Artery Spasm Related to Transradial Interventions Andrea Pacchioni et al TCT-402. Comparison of Procedural and Long-term Outcomes Between Transradial and Transfemoral Approach for Triple Vessel Coronary Artery Disease Intervention Kefei Dou et al TCT-403. Percutaneous Ultrasound-Guided Thrombin Injection as a Safe and Efficacious Primary Treatment of Iatrogenic Femoral Pseudoaneurysms for the Interventional Cardiologist Daniel Chen et al TCT-404. Efficacy and Safety of Total Percutaneous Femoral Closure Following Stent Graft Implantation Using Preclose Technique Donghoon Choi et al TCT-405. Transradial Approach Decreases in-hospital Mortality in Patients with Cardiogenic Shock: A Single- Center Experience Oriol Rodriguez-Leor et al TCT-406. Transradial Balloon Aortic Valvuloplasty Steven L. Goldberg et al TCT-407. Vascular Hemostasis Devices: Food and Drug Administration Perspective on Reported Risks Deborah L. Yoder et al TCT-408. Sheathless Guide Catheters in Complex Transradial PCI: A Single-Center Experience Raul M. Valdesuso et al TCT-409. Radial Access: Is There and Increased Risk of Operator Radiation Exposure During a Right vs. Left Radial Approach? Raul M. Valdesuso et al TCT-410. Arteriotomy Location Guided by Fluoroscopy Plus Real-time Ultrasound: In Defense of the Femoral Approach Raul M. Valdesuso et al TCT-411. Use of Sheathless Guide Catheter with Transradial Percutaneous Coronary Intervention: Single-Center Experience with 7,853 Procedures Mitsuru Kahata et al TCT-412. Diltiazem, Verapamil, or Dinitrate Isosorbid for Prevention of Radial Artery Spasm in Percutaneous Coronary Intervention Olivier Varenne et al TCT-413. Left and Right Heart Catheterizations Utilizing the Radial Artery and Forearm Vein: A Single-Center Experience Simone Muraglia et al TCT-414. Angiographic Predictive Factors of Vascular Complications After Transcatheter Aortic Valve In Patients Treated with Prostar Closure Device Manolis Vavuranakis et al TCT-415. Transradial Catheterization Is Not Associated with Increased Patient Radiation Exposure Compared to Transfemoral Access: A Meta-analysis Imdad Ahmed et al TCT-416. Did the RIVAL Trial Increase Transradial Coronary Intervention in Patients with Acute Myocardial Infarction? Results from Korea Working Group on Myocardial Infarction Registry Hye Won Lee et al TCT-418. Doppler Control of Radial Artery After Use of TR Band Following Coronarography and/or Angioplasty: DRABAND Study Results Jacques Monsegu et al TCT-419. Complete Percutaneous Approach for Arterial Access and Closure for Device Deployment in the Transfemoral Transcatheter Aortic Valve Replacement: A Comparison with Surgical Cut-down Tarun Chakravarty et al TCT-420. Major Vascular Complication and Its Management After Complete Percutaneous Arterial Access and Closure in Transfemoral Transcatheter Aortic Valve Replacement Mamoo Nakamura et al TCT-421. Lower Periprocedural Quality of Life in STEMI Patients Undergoing PCI with Femoral Access Lukasz Koltowski et al TCT-422. Large 22 Fr to 24 Fr Femoral Vein Hemostasis with a Subcutaneous Stitch or a Double Perclose Closure Is Effective and Safe Asma Hussaini et al TCT-423. Profile, Safety, and One-Year Outcome of Patients with Same-Day Discharge After Percutaneous Coronary Intervention Using Different Vascular Access: A High-Volume Single-Center Experience Asma Hussaini et al TCT-424. Trends in Access Site Choice for PCI and Influence on Mortality: Observational Data from the British Cardiovascular Intervention Society PCI Database Karim Ratib et al TCT-425. Repeated Transradial Catheterization: Feasibility, Efficacy, and Safety Marinos Charalambous et al TCT-426. Balloon Angioplasty Tamponade Facilitated Seal of Large Diameter Arteriotomy Vascular Access During Endovascular interventions from the SIMPLIPHIEDE Study (Single-Center Impella LVAD Supported PCI in High-Risk Group of Patients: Detroit Medical Center Experience) Obrad Kokanovic et al TCT-427. Transradial Access for Primary Percutaneous Coronary Interventions in Octogenarian Patients with Acute Myocardial Infarction: The ORA-STEMI (Octogenarians Radial Access in ST-Elevation Myocardial Infarction) Registry Antonio A. De Miguel et al TCT-428. Radial Access Does Not Affect Door-to-Balloon Time in Patients Undergoing Primary PCI Rosario Parisi et al Tuesday - October 23,

100 Tuesday, October 23 Challenging Case Video Presentations This session is not CME/CNE accredited. Session I. Highest Scored Submitted Cases 8:00 am-10:00 am Hall D Moderators: Robbert J. de Winter, Giuseppe M. Sangiorgi Discussants: Amr Abbas, Joseph D. Babb, YunDai Chen, Stéphane Cook, Nicola Corvaja, Henning Kelbaek, Guy LeClerc, Gabor Sutsch TCT Balloon-Expandable Aortic Prosthesis Dysfunction Due to Leaflet Thrombosis Linda Cota TCT A Novel Method of Stent Delivery by Mother-Child-Grandchild Technique Takashi Ashikaga TCT An Unusual Finding Following New Generation Drug-Eluting Stent Implantation Angelo Anzuini TCT Radial Artery Perforation During Transradial Catheterization Successfully Managed with Coil Embolization Hutton Brantley TCT Coronary Stent Retrieved from Lower Limb Rasheed Saadi TCT A Case of Acute Occlusive Dissection of the Right Coronary Artery Happened While Stenting to the Left Anterior Descending Artery Yoshiki Nagata TCT Retrograde Guidewire Trapping Technique Used for Chronic Total Occlusion with Anomalous Origin of Right Coronary Artery Long Hong TCT Successful Percutaneous Endovascular Retrieval of a Coil in Left Ventricle Migrated During Embolization for Pulmonary Arteriovenous Malformation Pyung Chun Oh TCT Giant Coronary Artery Aneurysm: Management of STEMI and Transcatheter Approach to Exclude Aneurysm Frances Wood TCT Successful Percutaneous Treatment of Left Main Coronary Artery Compromised by Extrinsic Compression from an Acquired Aneurysm of Left Sinus of Valsalva Peter Hausinger TCT Stenting of Right Coronary Artery Ostium for Acute Inferior Myocardial Infarction Due to Type A Aortic Dissection Veeran Subramaniam TCT Because Crossing Is Just the Beginning.... Complications of a Retrograde Chronic Total Occlusion Percutaneous Coronary Intervention Vishal Patel TCT Aortic Arch Aneurysm: Antegrade Transapical Stentgraft Placement with Transsupraaortic Chimney Grafts Michael Gawenda TCT Corsair Prolapse Causing Circulatory Collapse Ulf Jensen TCT An Unusual Myocardial Infarction Jacopo Oreglia TCT A New Effective Method Using a Child Catheter for Catching the Retrograde Wire Within the CTO Kensuke Yokoi TCT Pulmonary Venous Atrial Thrombus Leading to Killip IV Inferior and Anterolateral STEMI Complicated by Refractory Ventricular Fibrillation in a Patient with D-Transposition of Great Arteries and Anomalous Circumflex Artery and Prior Senning Atrial Switch Donald Lynch TCT Extensive Dissection of Unprotected Left Main Coronary Artery into Left Anterior Descending and Left Circumflex Arteries and Left Coronary Sinus During Percutaneous Coronary Intervention for Left Anterior Descending Artery: Step-by-Step Out-of-the-Box Solution Uday Khanolkar TCT Acute Coronary Syndrome and Bowel Ischaemia in a Patient with Extensive Fibromuscular Dysplasia Affecting the Coronary Ostia: High-Risk Left Main Coronary Artery PCI as a Last Resort Benjamin Wrigley TCT Guiding Catheter Dissection During Rotational Atherectomy: A Bail-Out Strategy Utilizing a 6-Fr Diagnostic Catheter Nanda Panigrahi TCT A Complicated Rescue PCI Involving a Left Main Trifurcation and Circumflex Rupture on a 38-Year-Old Male Prodromos Anthopoulos TCT Usuful Bifurcation Guidewire Technique: Reverse Wire Technique Taku Iwaki TCT Interventional Treatment of Acute Myocardial Infarction Due to Acute Aortic Dissection with Left Main Coronary Artery Compression Syndrome Kostadin Kichukov TCT The Long and Winding Road: Transcatheter Coiling and Use of a Vascular Plug for Treatment of Progressive Dyspnea and Right Heart Failure Secondary to Coronary Artery Fistulas Maya Kommineni TCT Anteretrograde Approach Technique Performed for CTO Case Tadashi Yamamoto TCT Balloon Aortic Valvuloplasty and Complex Left Main/Multivessel Percutaneous Coronary Intervention in a Patient with Severe Impaired Left Heart Function and High Syntax Score Ka Chun Alan Chan TCT An Enigmatic Vessel: Where and How to Go? Max Woo TCT Cutting the Edge with Cutting Edge Technology Auroa Badin TCT Retrograde CTO Techniques to Perform Left Main Stenting in an 18 Year Old with Previous Kawasaki Disease Elizabeth Holper TCT Successful Double Radial Approach RCA CTO PCI by Reverse CART Technique Through Epicardial Collateral After Two Failed Attempts Pengcheng He TCT Acute Left Main Coronary Infarction with Cardiogenic Shock Treated with Primary Stenting Assisted by Both PCPS and IABP Followed by Stem Cell Therapy Jae-hwan Lee TCT The Occlusive Crush Technique: A Novel Safe Method to Occlude Fistulas or to Stop Bleedings Alessandro Lualdi TCT LAD to LAD Retrograde Chronic Total Occlusion Recanalisation via an Intraseptal Loop Georgios Sianos TCT Percutaneous Coronary Intervention for Abnormal Ostium of Right Coronary Artery by 4-Fr Guiding Catheter via Transulnar Artery Approach Xianghua Fu TCT Left Main Coronary Artery Compression from Enlarged Pulmonary Artery Due to Pulmonary Hypertension Kazuho Kamishima TCT Peripartum Acute ST-Elevation Myocardial Infarction from Spontaneous Coronary Artery Dissection Ankur Kalra 98

101 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics TCT Successful Removal of an Intracoronary Foreign Body Mladen Vidovich TCT A Tail of Two Rings: Sequential Emergency PCI for Haemodynamic and Arrhythmic Complications of Mitral and Tricuspid Valve Repair Niket Patel TCT Unprotected Single Coronary Artery Main Stem Angioplasty Niket Patel TCT Combining CrossBoss, Laser, and Rotational Atherectomy Adjunctive Therapy for the Success in a Resistant Chronic Total Occlusion Nimit Shah TCT Double Crush Technique Using Simultaneous Dual Vascular Access Site to Treat Two Contiguous Bifurcation Lesions of the Left Anterior Descending Artery Karl Isaaz TCT Prior Recanalization of Saphenous Vein Graft Occlusive Lesion for Intravascular Ultrasound Guide Wiring to Select Native Right Coronary Artery Chronic Total Occlusion in Retrograde Approach Shuichi Ishizuka TCT A Case of Quadrification Stenting Prabhu Halkati TCT Primary Angioplasty in a Woman with Left Main Coronary Artery Occlusion and Cardiogenic Shock Ronen Jaffe TCT Successful PCI RCA CTO Requiring Staged Procedures as Well as Both Antegrade and Retrograde Approaches William Wilson TCT A Novel Technique of Controlled Antegrade Subintimal Tracking (CAT) to Cross Chronic Total Occlusion Sandeep Basavarajaiah TCT A Case of Massive Dissection of Left Main Anwar Khan TCT Unprotected Left Main PCI through a Fenestrated Type A Aortic Dissection Flap Alfred Burris Ii TCT Lund University Cardiac Arrest System (LUCAS) Assisted PCI in an Octogenarian Presenting with Cardiogenic Shock Periklis Davlouros TCT A case of FFR-guided coronary intervention to previous myocardial infarct area Issei Ishida TCT Complex Left Main PCI Done Without the Guiding Catheter Support J. Shivkumar Rao TCT Cutdown Carotid Revascularization Scott Schultz TCT A Challanging Case of PCI with Rotablation of the Last Major Patent Vessel Tariq Azeem TCT Severe Aortic Regurgitation Following Percutaneous Coronary Intervention Nimit Shah TCT Anteater Technique: Novel Use of the Guideliner Catheter Michael Luna TCT Primary PCI in Anomalous Coronary: Wire-First Approach Abhijit Kulkarni TCT Big Surprise After Successful Deployment of Two Tryton Stents: The Value of Patience Ricardo Sanz-Ruiz TCT Unusual Case of Left Main Coronary Artery Embolisation Narendra Khanna TCT Retrograde CTO with Single Guiding Catheter Pravin Goel TCT Evolving Applications for Rotational Atherectomy in the Subintimal Space to Facilitate Chronic Total Occlusion (CTO) Percutaneous Coronary Intervention (PCI) Vivek Kodoth TCT Use of the Guideliner Catheter to Implant Covered Stents in a Multistented Saphenous Vein Graft Presenting an Important False-Aneurysm Stephane Noble TCT Interventional Closure of Coronary Fistula in Heart Transplant Patient Markus Ferrari TCT Primary PCI with Mechanical Circulatory Support Andrew Asherson TCT Bridge to Recovery in a Patient with Churg-Strauss Myocarditis by Long-term Percutaneous Support with an Impella 2.5 Markus Ferrari TCT Aorto-Esophageal Fistula Presenting as a Life-threatening Problem Paramdeep Sandhu TCT Radial Percutaneous Transluminal Angioplasty with Stenting to Abdominal Aorta, Celiac Trunk, and Renal Artery in Takayasu Arteritis Keyur Parikh TCT Endovascular Repair of a Left Common Iliac Artery Aneurysm with Anomalous Renal Artery Supply to Crossed Renal Ectopia and its Periprocedural Complications Thomas George TCT Endovascular Repair of Descending Thoracic Aortic Pseudoaneurysm in a Patient with Loeys-Dietz II Syndrome Ankur Kalra TCT Retrograde Percutaneous Digital Artery Access for Challenging Case of Critical Limb Ischemia in Diabetic Patient Luis Palena TCT Acute Limb Ischemia Due to Abdominal Compartment Syndrome Atsuo Maeda TCT Endovascular Repair of Ascending Aortic Aneurysm by Transapical Approach and Chimney Technique Hans Krankenberg TCT Ultrasound Accelerated Thrombolysis: A Novel Approach for the Treatment of Right Atrial Clot in Transit Avichai Eres TCT Bilateral Renal Artery Stenosis of Which Left Renal Artery Is CTO Chandrashekhar Makhale TCT Percutaneous Revascularization of a Chronic Total Occlusion of the Left Lower Pulmonary Vein Dale Murdoch TCT Exclusion of Giant Pseudo Aneurysm with Stent Graft by Double Access Alejandro Goldsmit TCT Recanalization of an Occluded Superficial Artery Stent with Stent Puncture in Patient with Critical Limb Ischemia Roberto Gandini TCT Successful Recanalization of Inferior Vena Cava Obstruction Presenting as Hepatic Venous Outflow Obstruction in a Young Patient Dattatreya Rao TCT Acute Critical Hand Ischaemia Due to Brachial Artery Occlusion After Recanalisation from Left Radial Access Zoltán Ruzsa TCT Solitary Kidney Revascularization with Aortic Near-Occlusion for Renal Preservation Brian Kolski TCT Coeliac Artery Ostial CTO Angioplasty Through Retrograde Technique: So Near, Yet So Far Away Harinder Bali Tuesday - October 23,

102 Tuesday, October 23 TCT Use of a Double Snare Technique to Remove a Trapped Balloon Catheter from the Superior Vena Cava Salman Arain TCT Left Main Compression by a Huge Pulmonary Artery Aneurysm: Intravascular Ultrasound Analysis and Revascularization with a Drug-Eluting Stent Felipe Hernandez TCT A Case of Pressure Wire Fracture and Migration While Crossing a Bjork-Shiley Aortic Valve Monica Jiddou TCT Acute Left Main Occlusion During TAVI Pawel Kleczynski TCT Coronary Fistula to the Left Atrial Appendage Eduardo Infante De Oliveira TCT Transcatheter Aortic Valve Implantation for Pure Aortic Regurgitation as Bridge to Emergent Liver Transplantation Giuseppe Bruschi TCT Transfemoral Pulmonary Valve Implantation for Severe Pulmonary Insufficiency Following Ross Procedure Karl Stangl TCT Percutaneous Closure of a Giant Right Coronary Artery-Left Ventricular Coronary Cameral Fistula with Large Ostium Secundum Atrial Septal Defect Ravindranath Shankarappa TCT Transcatheter Tricuspid Valve-in-Valve Replacement Resulting in Four Different Prosthetic Heart Valves in a Single Patient Jean-Michel Paradis TCT Transcatheter Implantation of Degenerated Tricuspid Bioprosthesis with the 29-mm Edwards XT SAPIEN Valve Patrizia Presbitero TCT Challenging Case of Valve-in-Valve TAVI: The Importance of Attention to Fine Detail Narasimharajapura Rajendra TCT Percutaneous Transapical Closure of a Paravalvular Leak in a St. Jude Mechanical Mitral Valve Prosthesis: An Challenging Complication Karl Poon TCT Left Ventricular Embolization of an Aortic Balloon-Expandable Bioprosthesis: Balloon Capture and Reimpaction as an Alternative to Emergent Conversion to Open-Heart Surgery Nicolas Dumonteil TCT Interrupted Aortic Arch: Successful Endovascular Technique Using a Transseptal Needle Imad Alhaddad TCT The Challenge of Early Surgical and Transcatheter Closure of Post-Infarct Ventricular Septal Defect Frances Wood TCT Emergency Covered Stent Implantation for the Pulmonary Vein Rupture Following Balloon Angioplasty Takashi Matsumoto TCT Successful Antegrade Transfemoral Implantation of an Edwards Sapien Valve Within a Degenerated Mitral Valve Bioprosthesis in a Patient with Prior Surgical ASD Closure Simone Schleger TCT Percutaneous Mitral Valve Repair with the MitraClip Device in Acute Massive Mitral Regurgitation Complicated by Cardiogenic Shock Due to Papillary Muscle Rupture in a Patient with ST-Elevation Acute Myocardial Infarction (STEMI) Marco Barbierato TCT Personalized Medicine for Valvular Heart Disease: First-in-Man Percutaneous Pulmonary Valve-in-Valve Implantation Using 29-mm Edwards Sapien Valve Harsimran Singh TCT Percutaneous Closure of Paravalvular Leak After Transcatheter Aortic Valve Replacement Matthew Price TCT Left Main Coronary Artery Stenosis After Arterial Switch Operation in a 21-Year-Old Woman Treated With Drug-Eluting Stent Implantation Ricardo Sanz-Ruiz Oral Abstract Sessions These sessions are only CME accredited. Access Sites and Their Management 10:30 am-12:30 pm Room C219 Moderators: Ian C. Gilchrist, S. Chiu Wong Discussants: Luis A. Guzman, Christoph K. Naber, Sudhir Rathore, Stéphane Rinfret 10:30 am - TCT-25. Cardiac Catheterization via Ulnar: Deductive Approach After 10 Years of Experience Raul Valdesuso 10:40 am - Discussion 10:45 am - TCT-26. Radial vs. Femoral Access for Primary PCI: Observational Data from the British Cardiovascular Intervention Society Database Karim Ratib 10:55 am - Discussion 11:00 am - TCT-27. Transformation from a Predominant Transfemoral to Transradial Access Site for Percutaneous Coronary Intervention (PCI): Insights into an Achievable Revolution within Five Years Richard Anderson 11:10 am - Discussion 11:15 am - TCT-28. Is the Rate of Femoral Access Site Complications Increased in the Hands of Radialists? Stefano Rigattieri 11:25 am - Discussion 11:30 am - TCT-29. Radial vs. Femoral Access for Coronary Angiography and Intervention in Patients with Acute Coronary Syndromes: Results of the Zwolle Myocardial Infarction Study Group Rik Hermanides 11:40 am - Discussion 11:45 am - TCT-30. Clinical Outcomes Following Radial vs. Femoral Artery Access in Primary or Rescue Percutaneous Coronary Intervention in Scotland: Retrospective Cohort Study of 4,534 Patients Colin Berry 11:55 am - Discussion 12:00 pm - TCT-31. Clinical Benefit of Radial vs. Femoral Approach in Percutaneous Coronary Intervention with Intra-aortic Balloon Pump Support Enrico Romagnoli 12:10 pm - Discussion 12:15 pm - TCT-32. Neurological Complications Following PCI: Incidence and Trends During a Period of Transition from Femoral to Radial Access. Observational Data from the British Cardiovascular Intervention Society PCI Database Karim Ratib 12:25 pm - Discussion 12:30 pm - Adjourn Adjunct Imaging and Physiology 10:30 am-12:30 pm Room D239 Moderators: James A. Goldstein, Habib Samady Discussants: Allen Jeremias, Pedro A. Lemos, Jonathan S. Roberts, Pim A.L. Tonino 100

103 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics 10:30 am - TCT-17. Serial Changes of Everolimus-Eluting Stent Malapposition: An Optical Coherence Tomography Subanalysis from the RESET Trial Kunihiro Shimamura 10:40 am - Discussion 10:45 am - TCT-18. Long-term Outcome of Discordance Between Fractional Flow Reserve and Coronary Flow Velocity Reserve After Deferral of Percutaneous Coronary Intervention Tim P. van de Hoef 10:55 am - Discussion 11:00 am - TCT-19. Fractional Flow Reserved Derived from Computed Tomographic Angiography (FFRCT) for Intermediate Severity Coronary Lesions: Results from the DeFACTO Trial (Determination of Fractional Flow Reserve by Anatomic Computed TOmographic Angiography) James K. Min 11:10 am - Discussion 11:15 am - TCT-20. IVUS Predictors of Stent Thrombosis: Results from the Prospective, Multicenter ADAPT-DES Study Akiko Maehara 11:25 am - Discussion 11:30 am - TCT-21. Use of IVUS Reduces Stent Thrombosis: Results from the Prospective, Multicenter ADAPT-DES Study Bernhard Witzenbichler 11:40 am - Discussion 11:45 am - TCT-22. Combination of High Wall Shear Stress, Plaque Burden, and Plaque Phenotype Has Incremental Value for Prediction of Increased Plaque Vulnerability in Patients with Coronary Artery Disease Michel Corban 11:55 am - Discussion 12:00 pm - TCT-23. Detection by Near-Infrared Spectroscopy of Large Lipid Core Plaques at Culprit Sites in Patients with Acute ST-Segment Elevation Myocardial Infarction Ryan D. Madder 12:10 pm - Discussion 12:15 pm - TCT-24. Combined Near-Infrared Spectroscopic and Intravascular Ultrasound Assessment of Coronary Plaque Burden and Lipid Pools: Validation with Histology Rishi Puri 12:25 pm - Discussion 12:30 pm - Adjourn Bioresorbable Vascular Scaffolds 10:30 am-12:30 pm Room C Moderators: John A. Ormiston, Evelyn S. Regar Discussants: Raimund A. Erbel, Antoine Lafont, Detlef G. Mathey, Miodrag C. Ostojic 10:30 am - TCT-33. Intracoronary Optical Coherence Tomography and Histology of Overlapping Everolimus-Eluting Bioresorbable Vascular Scaffolds in a Porcine Coronary Artery Model: The Potential Implications for Clinical Practice Vasim Farooq 10:40 am - Discussion 10:45 am - TCT-34. ABSORB EXTEND: An Interim Report on the 12-Month Clinical Outcomes from the First 250 Patients Enrolled Antonio L. Bartorelli 10:55 am - Discussion 11:00 am - TCT-35. Evaluation of the Absorb Everolimus Eluting Bioresorbable Vascular Scaffold (Absorb BVS) in the Treatment of Patients with de Novo Native Coronary Artery Lesions: Three-Year Clinical Results of the ABSORB Cohort B1 Trial Peter C. Smits 11:10 am - Discussion 11:15 am - TCT-36. Circumferential Distribution of the Neointima Tissue at Six-Month and Two-Year Follow-up After a Bioresorbable Scaffold Implantation: A Serial Optical Coherence Tomography Study Christos Bourantas 11:25 am - Discussion 11:30 am - TCT-37. Five-year Clinical Outcomes and Noninvasive Angiographic Imaging Results with Functional Assessment After Bioresorbable Everolimus-Eluting Scaffold Implantation in Patients with De Novo Coronary Artery Disease Yoshinobu Onuma 11:40 am - Discussion 11:45 am - TCT-38. Two-Year Clinical Data of Cohort 1 and Multimodality Imaging Results Up to One-Year Follow-up of the BIOSOLVE-I Study with the Paclitaxel- Eluting Bioabsorbable Magnesium Scaffold (DREAMS) Michael Haude 11:55 am - Discussion 12:00 pm - TCT-39. Six-Month Angiographic Follow-up of the Novel DESolve Myolimus- Eluting Bioresorbable Coronary Scaffold for the Treatment of Noncomplex Coronary LesionsL Results from the DESolve I First-in-Man Trial Ricardo A. Costa 12:10 pm - Discussion 12:15 pm - TCT-40. Incidence and Acute Clinical Outcomes of Small Side Branch Occlusion After Implantation of Everolimus- Eluting Bioresorbable Vascular Scaffold in the ABSORB-EXTEND Single-Arm Trial Takashi Muramatsu 12:25 pm - Discussion 12:30 pm - Adjourn Carotid, Neurovascular, and Endovascular Intervention 10:30 am-12:30 pm Room C Moderators: Roger M. Greenhalgh, James D. Joye Discussants: Vivek Gupta, Daniel J. McCormick, Thomas M. Shimshak, Michael H. Wholey 10:30 am - TCT-1. Risk Factors for Cerebral Embolization After Carotid Artery Stenting with Embolic Protection: A DW-MRI Study in 827 Patients Klaudija Bijuklic 10:40 am - Discussion 10:45 am - TCT-2. Periprocedural Outcomes After Carotid Artery Stenting with the First 15,000 Patients Enrolled in the SAPPHIRE Worldwide Study D. Christopher Metzger 10:55 am - Discussion 11:00 am - TCT-3. Early Results of Multicenter, Prospective Trial of TEVAR for Blunt Thoracic Aortic Injury (RESCUE Trial) Ali Khoynezhad 11:10 am - Discussion 11:15 am - TCT-4. Impact of Catheter Fragmentation Followed by Local Intrapulmonary Thrombolysis in Acute High Risk Pulmonary Embolism as Primary Therapy: Acute and Long-term Outcomes Bishav Garg 11:25 am - Discussion 11:30 am - TCT-5. Efficacy of Cardiatis Multilayer Flow Modulator in Peripheral and Visceral Aneurysms Repair: Italian Multicenter Registry Results at One-Year Follow-up Maria Antonella Ruffino 11:40 am - Discussion Tuesday - October 23,

104 Tuesday, October :45 am - TCT-6. Biodegradable Polymerbased Biolimus A9-Eluting Stent for the Treatment of Infrapopliteal Arteries in Critical Limb Ischemia: Long-term Clinical and Angiographic Follow-up Eugenio Stabile 11:55 am - Discussion 12:00 pm - TCT-7. Plaque Excision as a Treatment Option for Critical Limb Ischemia: One-Year Results of the DEFINITIVE LE Study James F. McKinsey 12:10 pm - Discussion 12:30 pm - Adjourn Coronary Intervention I. Complex Lesions and Patient Subsets 10:30 am-12:30 pm Room C Moderators: Lisette Okkels Jensen, Richard A. Schatz Discussants: Adriano Caixeta, Luis Gruberg, Azeem Latib, Graham Nichol 10:30 am - TCT-65. Clinical Impact of IVUS-guided Left Main PCI: Insights from the Multicenter Study ESTROFA-LM Jose M. de la Torre Hernandez 10:40 am - Discussion 10:45 am - TCT-66. Impact of Residual Chronic Total Occlusion of Right Coronary Artery on the Long-term Outcome in Patients Treated for Unprotected Left Main Disease: The Milan and New Tokyo (MITO) Registry Kensuke Takagi 10:55 am - Discussion 11:00 am - TCT-67. Impact of Hemodynamic Support with Impella vs. Intraaortic Balloon Counterpulsation on Prognostically Important Ischemic Endpoints: Results from the PROTECT-II Trial George D. Dangas 11:10 am - Discussion 11:15 am - TCT-68. The Use of Percutaneous Left Ventricular Assist Device vs. Intra-aortic Balloon Pump for Hemodynamic Support During High-Risk PCI William W. O Neill 11:25 am - Discussion 11:30 am - TCT-69. PEPCAD-DES: A Randomized, Multicenter, Single-Blinded Trial Comparing Paclitaxel Coated Balloon Angioplasty with Plain Balloon Angioplasty in Drug-Eluting-stent Restenosis: 12-Month Results Harald Rittger 11:40 am - Discussion 11:45 am - TCT-70. Comparison of Efficacy and Safety Between Sirolimus, Paclitaxel, Everolimus-Eluting Stent and SeQuent Please, a Drug-Eluting Balloon on the Outcome of Patients with Diffuse In-Stent Restenosis after Bare Metal Stent Implantation Sunao Nakamura 11:55 am - Discussion 12:00 pm - TCT-71. Intravascular Ultrasound- Guided Systematic Two-Stent Techniques for Coronary Bifurcation Lesions Reduced Late Stent Thrombosis and ST-Elevation Myocardial Infarction Shao Liang Chen 12:10 pm - Discussion 12:15 pm - TCT-72. Impact of Gender on Adverse Cardiovascular Events Following Percutaneous Coronary Intervention: Pooled Analysis from the SPIRIT II, III, and IV Trials Usman Baber 12:25 pm - Discussion 12:30 pm - Adjourn Coronary Intervention II. Chronic Total Occlusions and Their Treatment 10:30 am-12:30 pm Room C220 Moderators: Mauro Carlino, Jonathan M. Hill Discussants: Kevin J. Beatt, Charles Chan, Masato Nakamura, Simon Walsh Chronic Total Occlusions and Their Treatment 10:30 am - TCT-73. Noninvasive Evaluation of Coronary Artery Collateral Flow Using Computed Tomographic Angiography Jin-Ho Choi 10:40 am - Discussion 10:45 am - TCT-74. Impact of Preprocedural Coronary CT Angiography on the Procedural Success of Percutaneous Coronary Intervention for Chronic Total Occlusion: A Multicenter Study of e-cto Investigators Jin-Ho Choi 10:55 am - Discussion 11:00 am - TCT-75. Lumen Enlargement of the Coronary Segments Located Distal to Chronic Total Occlusions Successfully Treated with Drug-Eluting Stents at Follow-up Josep Gomez-Lara 11:10 am - Discussion 11:15 am - TCT-76. Predictive Value of the J-CTO Score in Percutaneous Coronary Interventions for Chronic Total Occlusions Yves R. Louvard 11:25 am - Discussion 11:30 am - TCT-77. Initial and Midterm Angiographic Outcomes of Septal Channel Perforation Related to Retrograde Recanalization for Chronic Total Occlusions Hiroyuki Tanaka 11:40 am - Discussion 11:45 am - TCT-78. Long-term (Four-Year) Clinical Outcomes of Total Occlusions and Completeness of Revascularisation in the Synergy between Percutaneous Coronary Intervention with Taxus and Cardiac Surgery Trial Vasim Farooq 11:55 am - Discussion 12:00 pm - TCT-79. Chronic Total Occlusions in Sweden: Report from the Swedish Coronary Angiography and Angioplasty Registry (SCAAR) Truls R. Munddal 12:10 pm - Discussion 12:15 pm - TCT-80. Incidence of Periprocedual Myocardial Infarction in Chronic Total Occlusion PCI and Impact on Clinical Outcome Tasuku Hasegawa 12:25 pm - Discussion 12:30 pm - Adjourn Drug-Eluting Stents: Long-term Results 10:30 am-12:30 pm Room C Moderators: Kenneth Chin, Paul Vermeersch Discussants: Larry S. Dean, Daljeet S. Gambhir, Elvin Kedhi, Gervasio A. Lamas 10:30 am - TCT-41. The Impact of Left Main Disease on Long-term Clinical Outcomes Among Patients Treated With the Unrestricted Use of Everolimus-Eluting, Sirolimus-Eluting, and Paclitaxel-Eluting Stents: A Substudy of the Bern- Rotterdam Cohort Giulio Stefanini 10:40 am - Discussion 10:45 am - TCT-42. Long-term Safety and Efficacy of Percutaneous Coronary Intervention with Stenting and Coronary Artery Bypass Surgery for Left Main Disease: Final Five-Year Follow-up of the SYNTAX Trial Patrick W. Serruys 10:55 am - Discussion 11:00 am - TCT-43. Final Five-year Follow-up of the SYNTAX Trial: Optimal Revascularization Strategy in Patients with Three-vessel Disease Friedrich W. Mohr 11:10 am - Discussion

105 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics 11:15 am - TCT-44. LEADERS: Five-Year Follow-up from a Prospective, Randomized Trial of Biolimus A9-Eluting Stents with a Biodegradable Polymer vs. Sirolimus-Eluting Stents with a Durable Polymer: Final Report of the LEADERS study Patrick W. Serruys 11:25 am - Discussion 11:30 am - TCT-45. Long-term Safety and Effectiveness of XIENCE V Everolimus Eluting Coronary Stent System in Real-world Population: Three-Year Clinical Outcomes from the XIENCE V USA Study James B. Hermiller Jr 11:40 am - Discussion 11:45 am - TCT-46. Comparison of Polymer- Free BioFreedom? Stents with Durable Polymer Taxus Liberté Stents: Three-Year Results from the BioFreedom First-in-Man Trial Eberhard Grube 11:55 am - Discussion 12:00 pm - TCT-47. Two-Year Clinical Outcome of the TWENTE Trial, A Randomized Controlled Trial Comparing Second- Generation Zotarolimus-Eluting Resolute Stents vs. Everolimus-Eluting Xience V Stents in Real-world Patients Clemens von Birgelen 12:10 pm - Discussion 12:15 pm - TCT-48. Two-Year Follow-up and Subgroup Analysis of a Polymer-Free Sirolimus- and Probucol-Eluting Stent vs. A New Generation Zotarolimus-Eluting Stent in Coronary Artery Disease Lamin King 12:25 pm - Discussion 12:30 pm - Adjourn Interventional Pharmacology 10:30 am-12:30 pm Room D Moderators: James H. Chesebro, Marc Cohen Discussants: Jorge Gaspar, Christoph A. Kaiser, Norman E. Lepor, Keyur H. Parikh 10:30 am - TCT-49. A Comparison of 5 mg Prasugrel with 75 mg Clopidogrel in Very Elderly Coronary Artery Disease Patients: Pharmacodynamics and Rates of High On-Treatment Reactivity Joseph Jakubowski 10:40 am - Discussion 10:45 am - TCT-50. Influence of Age on Clinical Outcomes in Patients with NSTEMI Undergoing Treatment with Abciximab Plus Unfractionated Heparin vs. Bivalirudin: Analysis of the ISAR React 4 Study Lamin King 10:55 am - Discussion 11:00 am - TCT-51. Comparison of Clopidogrel and Prasugrel in Patients with Unprotected Left Main Disease Treated with Everolimus- Eluting Stents: Insight from the Florence Left Main-PCI Registry Renato Valenti 11:10 am - Discussion 11:15 am - TCT-52. Bivalirudin Reduces Cardiac Mortality in Patients with and Without Major Bleeding: The HORIZONS-AMI Trial Gregg W. Stone 11:25 am - Discussion 11:30 am - TCT-53. Assessment of 30-Day Rehospitalization for Acute Myocardial Infarction in Patients with Acute Coronary Syndrome Who Received Percutaneous Coronary Intervention: A Comparative Effectiveness Study of Clopidogrel And Prasugrel Jay Bae 11:40 am - Discussion 11:45 am - TCT-54. The Influence of Smoking Status on the Pharmacodynamics of Prasugrel and Clopidogrel: The PARADOX Study Paul A. Gurbel 11:55 am - Discussion 12:00 pm - TCT-55. Major Adverse Cardiac Events Associated with Discontinuation of Clopidogrel Treatment Within the First Year After Coronary Stent Implantation in Western Denmark Michael Maeng 12:10 pm - Discussion 12:15 pm - TCT-56. Incremental Value of Platelet Reactivity Over a Risk Score of Clinical and Procedural Variables in Predicting Bleeding Events After Percutaneous Coronary Intervention Fabio Mangiacapra 12:25 pm - Discussion 12:30 pm - Adjourn Renal Denervation and Hypertension 10:30 am-12:30 pm Room D Moderators: Stefan Verheye, Thomas Zeller Discussants: Maurizio Menichelli, Allan Schwartz, Christodoulos I. Stefanadis, Marco V. Wainstein 10:30 am - TCT-9. Morphological Assessment of Renal Arteries After Radiofrequency Catheter-based Sympathetic Denervation in a Porcine Model Michael Joner 10:40 am - Discussion 10:45 am - TCT-10. Efficacy of Renal Denervation is Positively Impacted by Longitudinal Treatments Meital Mazor 10:55 am - Discussion 11:00 am - TCT-11. Renal Sympathetic Denervation: Inducing an Instantaneous and Persisting 24h Ambulatory Blood Pressure Drop in Patients with Resistant Hypertension: Results from the Halle-RDN-Registry Alexander Plehn 11:10 am - Discussion 11:15 am - TCT-12. Long-term Follow-up of Catheter-Based Renal Denervation for Resistant Hypertension Confirms Durable Blood Pressure Reduction Markus R. Schlaich 11:25 am - Discussion 11:30 am - TCT-13. Renal Resistive Indices, Urinary Albumin Excretion and Renal Function in Patients with Resistant Hypertension After Catheter-Based Renal Sympathetic Denervation Felix Mahfoud 11:40 am - Discussion 11:45 am - TCT-14. Effects of Renal Sympathetic Denervation on Heart Rate and Atrioventricular Conduction in Patients with Resistant Hypertension Christian Ukena 11:55 am - Discussion 12:00 pm - TCT-15. Histomorphometric Evaluation of 2-D Characteristics and 3-D Sympathetic Renal Nerve Distribution in Hypertensive vs. Normotensive Patients Giuseppe M. Sangiorgi 12:10 pm - Discussion 12:15 pm - TCT-16. Renal Artery Nerve Distribution and Density in the Porcine Model: Biological Implications for the Development of Radiofrequency Ablation Therapies Armando Tellez 12:25 pm - Discussion 12:30 pm - Adjourn STEMI/NSTEMI and Primary PCI 10:30 am-12:30 pm Room D Moderators: Thomas Aversano, Rajesh M. Dave Discussants: Karel T. Koch, Suhas S. Lele, Massimo Napodano, On Topaz Tuesday - October 23, 2012

106 Tuesday, October 23 10:30 am - TCT-57. Angiographic Reperfusion Indices Predict Infarct Size and Mortality: The INFUSE-AMI Trial Sorin J. Brener 10:40 am - Discussion 10:45 am - TCT-58. Effects of Mechanical Thrombectomy and Intracoronary Abciximab on Coronary Flow and Infarct Size During Primary PCI: Analysis from the INFUSE-AMI Trial Jan-Henk Dambrink 10:55 am - Discussion 11:00 am - TCT-59. Effect of Intracoronary Abciximab and Aspiration Thrombectomy on Microvascular Obstruction in Large Anterior Myocardial Infarction: The INFUSE-AMI MRI Substudy Akiko Maehara 11:10 am - Discussion 11:15 am - TCT-60. CompariSon of Manual Aspiration with Rheolytic Thrombectomy in Acute Myocardial Infarction: The Final Six-Month Results of the SMART Primary PCI Trial Guido Parodi 11:25 am - Discussion 11:30 am - TCT-61. Infarct Size-Determined Uptake of CD34+ Cells in the Peri-Infarct Zone and Left Ventricular Remodeling: Insights from Integration of Labeled Cells Uptake SPECT Visualization with Sequential Cardiac MRI Piotr Musialek 11:40 am - Discussion 11:45 am - TCT-62. Impact of Atrial Fibrillation in Patients with STEMI Before and After Primary PCI: Insights from the HORIZONS-AMI Trial A. Rene 11:55 am - Discussion 12:00 pm - TCT-63. Remote Ischemic Perconditioning Improves Long-term Clinical Outcome in Patients Undergoing Primary Percutaneous Coronary Intervention for ST-Elevation Myocardial Infarction Astrid D. Sloth 12:10 pm - Discussion 12:15 pm - TCT-64. Bypassing the Emergency Department is Associated with Faster Reperfusion in Patients with Pre-hospital ST-segment Elevation: Findings from the Reperfusion of Acute Myocardial Infarction in Carolina Emergency Departments (RACE) Project Akshay Bagai 12:25 pm - Discussion 12:30 pm - Adjourn Structural and Nonvalvular Intervention 10:30 am-12:30 pm Room D Moderators: Steven L. Almany, Gerhard C. Schuler Discussants: Zahid Amin, Mark Goldberger, Randall J. Lee, Matthew J. Price 10:30 am - TCT-371. First Clinical Evaluation of a Novel Percutaneous Right Ventricular Assist Device: The Impella RP Anson Cheung 10:40 am - Discussion 10:45 am - TCT-82. Cost-effectiveness Of Transcatheter Left Atrial Appendage Occlusion Compared with Five Alternative Anticoagulation Strategies for Stroke Prevention in Atrial Fibrillation: A Markov Decision Analysis Bryan Yan 10:55 am - Discussion 11:00 am - TCT-83. Watchman Left Atrial Appendage Closure in Atrial Fibrillation Patients with Contraindication to Oral Anticoagulation: the Aspirin Plavix Registry (ASAP) Horst Sievert 11:10 am - Discussion 11:15 am - TCT-84. Watchman Left Atrial Appendage Closure in Atrial Fibrillation Patients 75 Years or Greater; A Sub-Analysis of the PROTECT AF Study Saibal Kar 11:25 am - Discussion 11:30 am - TCT-85. Efficacy and Safety of Percutaneous Patent Foramen Ovale Closure in Patients with a Hypercoagulable Disorder Ignacio Cruz-Gonz lez 11:40 am - Discussion 11:45 am - TCT-86. Results of the Amplatzer Cardiac Plug European Multicenter Prospective Observational Study Jai-Wun Park 11:55 am - Discussion 12:00 pm - TCT-87. Safety and Efficacy of the MitraClip for the Treatment of Patients with a Dilated Left Ventricle and Functional Mitral Regurgitation Anita Asgar 12:10 pm - Discussion 12:15 pm - TCT-81. Long-term Safety and Efficacy of Percutaneous Left Ventricular Transapical Access and Closure for Structural Heart Disease Interventions Chad Kliger 12:25 pm - Discussion 12:30 pm - Adjourn Transcatheter Aortic Valve Replacement I 10:30 am-12:30 pm Room D Moderators: Wesley R. Pedersen, Leif Thuesen Discussants: Todd M. Dewey, Brij Maini, Oscar A. Mendiz, Vinod H. Thourani 10:30 am - TCT-89. Timing, Predictive Factors and Prognostic Value of Cerebrovascular Events in a Large Cohort of Patients Undergoing Transcatheter Aortic Valve Implantation Luis Nombela-Franco 10:40 am - Discussion 10:45 am - TCT-90. Predictive Factors and Long-Term Clinical Consequences of Persistent Left Bundle Branch Block Following Transcatheter Aortic Valve Implantation with a Balloon- Expandable Valve Maria Urena 10:55 am - Discussion 11:00 am - TCT-91. Perivalvular Aortic Regurgitation in Balloon-Expendable and Self-expendable TAVI Procedures: Predictors and Impact on Clinical Outcome: Insights from the FRANCE2 Registry Eric van Belle 11:10 am - Discussion 11:15 am - TCT-92. Does Mitral Regurgitation Impact the Outcome of TAVI Procedures? Insights from the FRANCE2 Registry Eric van Belle 11:25 am - Discussion 11:30 am - TCT-93. Relationship of Transcatheter and Surgical Aortic Valve Replacement with Left Ventricular Function in High-Risk Patients with Aortic Stenosis Sammy Elmariah 11:40 am - Discussion 11:45 am - TCT-94. Outcomes of Patients with Severe Aortic Stenosis and Chronic Obstructive Pulmonary Disease Treated with Transcatheter vs. Surgical Aortic Valve Replacement vs. Medical Therapy Danny Dvir 11:55 am - Discussion 12:00 pm - TCT-95. Outcomes of Transcatheter vs. Surgical Aortic Valve Replacement in Women: Insights from the Randomized PARTNER Trial Mathew Williams 12:10 pm - Discussion 104

107 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics 12:15 pm - TCT-96. Influence of Gender on Clinical Outcomes Following Transcatheter Aortic Valve Implantation: Results from the UK TAVI Registry on Behalf of the UK TAVI Steering Group and the National Institute for Cardiovascular Outcomes Research Rasha Al-Lamee 12:25 pm - Discussion 12:30 pm - Adjourn Transcatheter Aortic Valve Replacement II 10:30 am-12:30 pm Room D Moderators: Ganesh Manoharan, Brad I. Munt Discussants: Pamela S. Douglas, Chaim S. Lotan, Bernhard Reimers, Alfredo Trento 10:30 am - TCT-97. Three-dimensional Echocardiographic Measurements of the Aortic Annulus Predict Paravavular Regurgitation Following Transcatheter Aortic Valve Replacement Rebecca Tung Hahn 10:40 am - Discussion 10:45 am - TCT-98. The Impact of Effective Aortic Annulus Sizing by 3-D Computed Tomography on Paravalvular Leak Development After Transcatheter Aortic Valve Implantation Fabian Plank 10:55 am - Discussion 11:00 am - TCT-99. The Vancouver Computed Tomography Sizing Guidelines for Transcatheter Aortic Valve Replacement with Balloon-Expandable Valves Alex Wilson 11:10 am - Discussion 11:15 am - TCT-100. Transcatheter Aortic Valve Replacement for Degenerative Bioprosthetic Surgical Valves: Results from the Global Valve-in-Valve Registry Danny Dvir 11:25 am - Discussion 11:30 am - TCT-101. Twelve-Month Results of a Second-Generation Transapical Aortic Bioprosthesis for the Treatment of Patients with Severe Aortic Stenosis Joerg Kempfert 11:40 am - Discussion 11:45 am - TCT-102. Transapical Aortic Valve Implantation: Six- and 12-Month Results from a Multicenter Study Using the JenaValve Second-Generation Transcatheter Aortic Valve Implantation System Hendrik Treede 11:55 am - Discussion 12:00 pm - TCT-103. The Transaortic Approach for Transcatheter Aortic Valve Replacement: Initial Clinical Experience in the United States Joel Lardizabal 12:10 pm - Discussion 12:15 pm - TCT-104. Feasibility Study of the Repositionable Lotus Aortic Valve Replacement System: Three-Month Outcomes in 11 Patients at High Surgical Risk (REPRISE I) Ian T. Meredith 12:25 pm - Discussion 12:30 pm - Adjourn Presentation Theater 12:15 pm-1:15 pm Please see page 165 for the Presentation Theater schedule. Scientific Symposia Endovascular Intervention 2012 (Part 2) 1:00 pm-6:00 pm Room A This session is only CME accredited. Session VI. LINC at TCT: Special Section on Lower Extremity Intervention Moderators: Dierk Scheinert, Andrej Schmidt Discussants: Max Amor, John R. Laird Jr, Craig M. Walker, Thomas Zeller Interventional Techniques for Complex Aortoiliac Occlusions 1:00 pm - Recanalization of Aortoiliac CTOs: Access Strategies and the Value of Occlusion Devices John R. Laird Jr 1:07 pm - Balloon-Expandable vs. Self- Expanding vs. Covered Stents In Iliac Arteries: Insights from Clinical Trials and Clinical Practice Tony Das 1:14 pm - Brachial and Radial Approaches for Iliofemoral Interventions Max Amor 1:21 pm - Discussion with Q&A Recorded Case 1:26 pm - Percutaneous Reconstruction of a Complete Aortoiliac Occlusion (Leriche Syndrome) 1:41 pm - Discussion with Q&A Advanced Approaches for Femoropoliteal Occlusions 1:46 pm - Tips and Tricks for Successful Crossing of Femoropopliteal CTOs Andrej Schmidt 1:53 pm - After CTO Recanalization, What Is the Role of Drug-Eluting Devices, Covered Stents, Etc? Thomas Zeller 2:00 pm - The Last Frontier: Interventional Techniques for Recanalization of the Popliteal Artery Dierk Scheinert 2:07 pm - Discussion with Q&A Recorded Case 2:12 pm - Retrograde SFA Recanalization for In-Stent-Occlusion with Puncture of the Occluded Stents 2:27 pm - Discussion with Q&A Pioneering Techniques for Revascularization in Critical Limb Ischemia 2:32 pm - The Angiosome Concept in Clinical Practice: Implications for Patient-Specific Revascularization Approaches Lindsay S. Machan 2:39 pm - Access and Techniques for Retrograde Tibial Recanalization Craig M. Walker 2:46 pm - Recanalization of Pedal Arteries: Anatomy, Imaging, and Wiring Techniques Marco Manzi 2:53 pm - Discussion with Q&A Recorded Cases 2:58 pm - Retrograde Tibial Recanalization 3:13 pm - Discussion with Q&A Session VII. Infrapopliteal Intervention Moderators: Alex Powell, Krishna J. Rocha-Singh Discussants: William H. Julien, Hugo F. Londero, Robert A. Lookstein, Erich Minar Overview and Latest Developments 3:18 pm - Intervention for Claudication Due to Infrapopliteal Disease: Targets and Techniques Hans Krankenberg Tuesday - October 23,

108 Tuesday, October 23 3:25 pm - Planning Infrapopliteal Intervention for CLI: Approach and Toolbox Options Mahmood K. Razavi 3:32 pm - A Multidisciplinary Approach to CLI Is Essential: Wound Care, Risk Factor Modification, and Endovascular Therapy James P. Zidar 3:39 pm - Blue-Toe Syndrome: Does Thrombolysis Have a Place? Thomas O. McNamara 3:46 pm - Importance of Sustained Patency and the Role of DES for Infrapopliteal Intervention Robert A. Lookstein 3:53 pm - Discussion with Q&A Mini-Debates 4:00 pm - Debate 1: Is Endovascular Intervention the First-line Therapy for CLI? Pro! Tony Das 4:05 pm - Debate 1: Is Endovascular Intervention the First-line Therapy for CLI? Con! Jacques Busquet 4:10 pm - Debate 1: Discussion and Vote 4:15 pm - Debate 2: Is Straight-Line Flow to the Foot Sufficient (And Is the Angiosome Concept Nonsense)? Pro! Mehdi H. Shishehbor 4:20 pm - Debate 2: Is Straight-Line Flow to the Foot Sufficient (And Is the Angiosome Concept Nonsense)? Con! Andrej Schmidt 4:25 pm - Debate 2: Discussion and Vote 4:30 pm - Debate 3: Is Long-term Patency Following Tibial Intervention for Critical Limb Ischemia Necessary? Pro! Thomas Zeller 4:35 pm - Debate 3: Is Long-term Patency Following Tibial Intervention for Critical Limb Ischemia Necessary? Con! Alex Powell 4:40 pm - Debate 3: Discussion and Vote Session VIII. Vascular Complications Moderators: Robert D. Safian, Robert M. Schainfeld Discussants: John A. Bittl, Anthony J. Comerota, Constantino S. Pena, Luigi Salemme Access Site Complications 4:45 pm - Femoral Access Site Complications: Diagnostic and Therapeutic Tips and Tricks Stephen R. Ramee 4:52 pm - Failures and Complications of Closure Devices: Device-Specific Characterization and Management Robert M. Schainfeld 4:59 pm - Radial, Brachial, and Axillary Access: Tips for Success and Traps for Disaster Lindsay S. Machan 5:06 pm - Discussion with Q&A target Vessel Complications 5:11 pm - Vessel Rupture and Perforation: Frequency, Locations, and Management Zvonimir Krajcer 5:18 pm - Selection and Use of Coils for Embolization of Perforations John H. Rundback 5:25 pm - Selection and Use of Stent Grafts for Vessel Rupture James F. Benenati 5:32 pm - Discussion with Q&A Life-Threatening or Fatal vascular Complications: Case Presentations 5:37 pm - Case 1: During a TAVR Susheel Kodali 5:42 pm - Case 2: During an EVAR or TEVAR James F. McKinsey 5:47 pm - Case 3: During an Iliofemoral Intervention D. Christopher Metzger 5:52 pm - Case 4: During Carotid Artery Stenting: Extracerebral or Access Vessel Related Fayaz Shawl 6:00 pm - Adjourn First-in-Human Studies: Global Regulatory and Translational Considerations 1:00 pm-6:00 pm Room B This session is only CME accredited. Session I. Bioabsorbable Vascular Scaffolds Moderators: Jacques J. Koolen, John A. Ormiston Discussants: Syed Hossainy, Greg L. Kaluza, Paul J. Miller, Richard J. Rapoza, Pamela P. Simons, Mitchell Sugarman, Ron Waksman 1:00 pm - State-of-the-Field Keynote: Impact of Emerging Biomaterials on Next- Generation Bioabsorbable Vascular Scaffold Development Syed Hossainy 1:15 pm - Preclinical Review: Update on Emerging Programs and Validation Methods Greg L. Kaluza 1:25 pm - Early Human Clinical Studies: Patient Selection, Technical Considerations, and Endpoints John A. Ormiston 1:35 pm - Highlighted Abstract: TCT-563. Multicenter, First-in-Man Evaluation of the Myolimus-Eluting Bioresorbable Coronary Scaffold: Six-Month Clinical and Imaging Results Stefan Verheye 1:45 pm - Discussion with Q&A Session II. Drug-Coated Balloons Moderators: Elazer R. Edelman, John A. Ormiston Discussants: Juan F. Granada, Greg L. Kaluza, Paul J. Miller, Dierk Scheinert, Bruno Scheller, Pamela P. Simons, Mitchell Sugarman, Gunnar Tepe 2:00 pm - State-of-the-Field Keynote: Technical and Biological Challenges for Future DCB Development Juan F. Granada 2:15 pm - Preclinical Review: Experimental Pathways for Evaluation of Drug Transfer, Tissue Pharmacokinetics, and Vascular Effects Elazer R. Edelman 2:25 pm - Early Human Clinical Studies: Patient Selection, Technical Considerations, and Endpoints Dierk Scheinert 2:35 pm - Highlighted Abstract: TCT-585. Six-Month Results of the BIOLUX PI First-in-Man Study Comparing a Paclitaxel- Releasing Balloon Catheter vs. an Uncoated Balloon Catheter in Femoropopliteal Lesions Dierk Scheinert 2:45 pm - Discussion with Q&A Session III. Transcatheter Aortic Valve Replacement (TAVR) Moderators: Juan F. Granada, Renu Virmani Discussants: Todd M. Dewey, Susheel Kodali, Jean-Claude Laborde, Ian T. Meredith, Paul J. Miller, Stanton J. Rowe, Pamela P. Simons, Mitchell Sugarman 3:00 pm - State-of-the-Field Keynote: Emerging Opportunities for Future TAVR Development: Stroke, Paravalvular Leaks, and Beyond Susheel Kodali 3:15 pm - Preclinical Review: Experimental Considerations and Challenges for TAVR Validation Stanton J. Rowe 3:25 pm - Early Human Clinical Studies: Patient Selection, Technical Considerations, and Endpoints Ian T. Meredith 106

109 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics 3:35 pm - Highlighted Abstract: TCT-800. Transcatheter Aortic Valve Replacement (TAVR) with a New Self-Expanding Percutaneous Heart Valve and Motorized Delivery System Ronald Binder 3:45 pm - Discussion with Q&A Session IV. Interventional Heart Failure Moderators: Marvin J. Slepian, Renu Virmani Discussants: Daniel Burkhoff, JoAnn Lindenfeld, Paul J. Miller, Pamela P. Simons, Mitchell Sugarman 4:00 pm - State-of-the-Field Keynote: Future Perspectives in the Device-Based Treatment for Heart Failure Daniel Burkhoff 4:15 pm - Preclinical Review: Experimental Models and Biological Considerations for the Validation of Heart Failure Devices Juan F. Granada 4:25 pm - Early Human Clinical Studies: Patient Selection, Technical Considerations, and Endpoints William T. Abraham 4:35 pm - Highlighted Abstract: TCT-88. Three-Year Clinical Outcomes of the First-in-Human Experience with Percutaneous Ventricular Restoration Using the Parachute Device in Patients with Ischemic Heart Failure and Dilated Left Ventricle Marco A. Costa 4:45 pm - Discussion with Q&A Session V. Renal Artery Denervation Moderators: Juan F. Granada, Renu Virmani Discussants: Deepak L. Bhatt, Tim A. Fischell, James R. Margolis, Paul J. Miller, Pamela P. Simons, Paul A. Sobotka, Mitchell Sugarman 5:00 pm - State-of-the-Field Keynote: The Next Challenge: Improving Technical Efficiency and Biological Response (Nonresponders) Deepak L. Bhatt 5:15 pm - Preclinical Review: Perirenal Nerve Distribution, Density, and Quantification: Implications for the Evaluation of Device Safety and Efficacy Renu Virmani 5:25 pm - Early Human Clinical Studies: Patient Selection, Technical Considerations, and Endpoints Paul A. Sobotka 5:35 pm - Highlighted Abstract: TCT-356. Circumferential Therapeutic Ultrasound for the Treatment of Resistant Hypertension: Preliminary Results of Human Feasibility Study (SOUND-ITV) Peter Neuzil 5:45 pm - Discussion with Q&A 6:00 pm - Adjourn Hot Topics in Cardiology: ACC.12 with TCT Highlights for the Interventional, Invasive, and General Cardiologist 1:00 pm-6:05 pm Ballroom A Welcome and Introduction to the ACC.12 with TCT HIghlight Session Patrick T. O Gara, E. Murat Tuzcu Session I. Acute Coronary Syndrome Updates Moderators: Ajay J. Kirtane, Sunil V. Rao Discussants: Steven R. Bailey, Jessica L. Mega 1:05 pm - Introduction Ajay J. Kirtane, Sunil V. Rao 1:10 pm - Legends Video: Braunwald: Reducing MI Size 1:13 pm - Late Breaking Trials: BRIDGE-ACS (Multimodality Approach to Adherence), INFUSE-AMI (STEMI), and IMMEDIATE (GIK) Ajay J. Kirtane 1:23 pm - Legends Video: Fuster: Vulnerable Plaque and Thrombosis 1:26 pm - Point-of-Care Platelet and Genetic Testing Jessica L. Mega 1:36 pm - Year in Review: ACS and STEMI Steven R. Bailey 1:52 pm - Legends Video: Colombo: PCI 1:55 pm - State of the Art Sunil V. Rao 2:05 pm - Discussion with Q&A Session II. Stable Ischemic Heart Disease Updates Moderators: Rudiger Lange, David A. Morrow Discussant: Robert D. Simari 2:15 pm - Introduction Rudiger Lange, David A. Morrow 2:20 pm - Late Breaking Trials: CORONARY (On-Pump vs. Off-Pump CABG), CPORT (Nonprimary PCI Without Surgical Backup), ASCERT (CABG vs. PCI), and TRAP2-TIMI 50 (Vorapaxar for SIHD Patients) David A. Morrow 2:36 pm - Stem Cell Therapies: State of the Art (Including the FOCUS Trial) Robert D. Simari 2:52 pm - Innovators Video: Mack 2:55 pm - Discussion with Q&A Session III. Prevention Updates Moderators: Elizabeth A. Jackson, Jeffrey T. Kuvin Discussants: Deepak L. Bhatt, Donna Polk 3:05 pm - Introduction Elizabeth A. Jackson, Jeffrey T. Kuvin 3:08 pm - Legends Video: Fuster (Polypill) 3:11 pm - Late Breaking Trials: STAMPEDE (Bariatric Surgery) and PCSK9 (LDL Reduction) Elizabeth A. Jackson 3:19 pm - Hypertension: Renal Denervation Deepak L. Bhatt 3:25 pm - Legends Video: Yacoub (Africa) 3:28 pm - Late Breaking Trials: Venous Thromboembolic Disease EINSTEIN-PE (Rivaroxaban) Jeffrey T. Kuvin 3:34 pm - Year in Review: Preventative Cardiology Donna Polk 3:40 pm - Discussion with Q&A Session IV. Imaging Updates Moderators: Karthik Ananthasubramaniam, Issam Mikati Discussant: Robert O. Bonow 3:50 pm - Introduction Karthik Ananthasubramaniam 3:55 pm - Late Breaking Trials: ACRIN-PA (CTA in Low-Intermediate Risk Chest Pain) and ROMICAT II (CTA in Low-Intermediate Risk Chest Pain) Issam Mikati 4:04 pm - Viability Testing, Clinical Decision Making TBA 4:13 pm - Year in Review: Cardiovascular Imaging Karthik Ananthasubramaniam 4:22 pm - Innovators Video: Narula (Molecular Imaging) 4:25 pm - Discussion with Q&A Session V. Heart Failure Updates Moderators: Biykem Bozkurt, Dennis M. McNamara Discussants: William T. Abraham, Sharon Hunt, E. Magnus Ohman 4:35 pm - Introduction Biykem Bozkurt, Dennis M. McNamara 4:40 pm - Circulatory Support for Cardiogenic Shock E. Magnus Ohman Tuesday - October 23,

110 Tuesday, October 23 4:46 pm - Contemporary LVAD Therapy: Destination, Recovery, Bridge? Sharon Hunt 4:51 pm - Treatment of Acute Decompensated HF Dennis M. McNamara 4:57 pm - Updated CRT Guidelines William T. Abraham 5:03 pm - Year in Review: Heart Failure Therapies Biykem Bozkurt 5:10 pm - Discussion with Q&A Session VI. Arrhythmia Updates Moderators: Peter A. Brady, Ralph J. Verdino Discussants: Gust Bardy, John Camm 5:20 pm - Introduction Peter A. Brady, Ralph J. Verdino 5:23 pm - Subcutaneous Defibrillators Gust Bardy 5:31 pm - Management of the Device Patient for the Non-EP MD Ralph J. Verdino 5:39 pm - Atrial Fibrillation: (1) CHADS2 vs. CHA2DS2-VASc Risk Assessment, and (2) AHA/ACC vs. ACCP/ESC Approach to Stroke Prevention. Peter A. Brady 5:47 pm - Year in Review: Arrhythmias John Camm 5:55 pm - Discussion with Q&A 6:00 pm - Adjourn Identifying the High-Risk Patient and Lesion: From Vulnerable Plaque to Ischemia 1:00 pm-6:10 pm Room B Session I. Ischemia, Vulnerable Plaque, and the Vulnerable Patient Moderators: Daniel S. Berman, Daniel I. Simon Discussants: Adam J. de Belder, Henricus J. Duckers, Dariusz Dudek, Pedro R. Moreno, Nico H.J. Pijls, Robert L. Wilensky 1:00 pm - Introductory Lecture. A New Paradigm Revisited: From Ischemia to Vulnerable Plaque Gregg W. Stone 1:10 pm - Pathogenesis of Vulnerable Plaque 2012: What s New? Renu Virmani 1:20 pm - Blood, Tissue, and Genetic Markers for Vulnerable Plaque: From Theory to Practice Jozef Bartunek 1:30 pm - Is Ischemia a Marker of Plaque Vulnerability and Future Thrombosis? Bernard De Bruyne The Great Vulnerable Plaque Debate: Is Vulnerable Plaque a Systemic or Focal Disease? 1:40 pm - Vulnerable Plaque Is a Systemic Inflammatory and Vascular Disease Valentin Fuster 1:50 pm - Most Diseases Are Systemic: It s the Focal Manifestations that Count! James E. Muller 2:00 pm - The Vulnerable Mind: Connections Between the Cortex and Coronaries Amir Lerman 2:10 pm - Discussion with Q&A Session II. Noninvasive Imaging to Identify the High-Risk Patient and Plaque Moderators: Jonathon A. Leipsic, Robert S. Schwartz Discussants: Stephen E. Epstein, Roger J. Laham, Konstantinos Toutouzas, Antonius F.W. van der Steen 2:25 pm - CTA Imaging and Prognosis: From Calcium Scoring to Coronary Anatomy Szilard Voros 2:35 pm - Potential Role for Pan-Vascular Imaging: Insights from the HRP Project Valentin Fuster 2:45 pm - The Case for CT-FFR as the Optimal Screening Tool: Latest DEScover and DeFACTO Results Jonathon A. Leipsic 2:55 pm - Reevaluating the Radiation Risk of CT Angiography Andrew J. Einstein 3:05 pm - Statement: Molecular Imaging Will Transform the Evaluation of Atherosclerosis! Farouc Jaffer 3:15 pm - Advanced Imaging for Vulnerable Plaque Detection: The Future Is (Almost) Now! Jagat Narula 3:25 pm - Discussion with Q&A Session III. Invasive Imaging to Identify the High-Risk Patient and Plaque Moderators: James A. Goldstein, Antonius F.W. van der Steen Discussants: Takashi Akasaka, Takashi Kubo, Francesco Prati, Evelyn S. Regar, Habib Samady 3:40 pm - Should VH-IVUS Be Used as a Clinical Tool to Detect and Treat Vulnerable Plaque TODAY: From PROSPECT to VIVA Patrick A. Calvert 3:50 pm - OCT as a Clinical Tool for Vulnerable Plaque Detection: New Insights and Future Studies Shiro Uemura 4:00 pm - NIRS as a Clinical Tool for Vulnerable Plaque Detection: Findings in Patients with Acute STEMI Ryan D. Madder 4:10 pm - Implications of Low- and High-Shear Stress to Atherosclerosis Progression and Rupture: Predictions Beyond PREDICTION Peter H. Stone 4:20 pm - Vignettes on Plaque Stability 1: Insights from the VH Registry and HORIZONS-AMI Akiko Maehara 4:25 pm - Vignettes on Plaque Stability 2: Insights from Serial Imaging in IBIS II Hector M. Garcia-Garcia 4:30 pm - Discussion with Q&A Session IV. Therapeutic Implications of the High-Risk Patient and Plaque Moderators: John A. Ambrose, Robert D. Simari Discussants: Raimund A. Erbel, Sheldon Goldberg, Daniel I. Simon, Christodoulos I. Stefanadis 4:45 pm - Do Statins and Other Therapies Alter Vulnerable Plaque Characteristics? Insights from Imaging Pedro R. Moreno 4:55 pm - Darapladib and STABILITY Update Harvey D. White 5:05 pm - PCSK9 Inhibitors: The Holy Grail? Evan A. Stein 5:15 pm - The HDL Hypothesis: A Critical Reappraisal Robert L. Wilensky 5:25 pm - Therapies Based on ApoA1 and ApoA1 Milano: Overview of the Field Bryan Brewster 5:35 pm - What Will It Take for Focal Therapy of Vulnerable Plaque to Become a Reality? Preclinical and Clinical Insights Patrick W. Serruys 5:45 pm - Nanoparticle-Based Therapies for Atherosclerosis: The NANOM FIM Study Alexander N. Kharlamov 5:55 pm - Discussion with Q&A 6:00 pm - Adjourn 108

111 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics Interventional Heart Failure 1:00 pm-6:10 pm Room B This session is not CME/CNE accredited. Session I. Keynote Address Moderators: William T. Abraham, Stefan Anker 1:00 pm - New Devices in the Old World: A European View of Device Development for Heart Failure Stefan Anker Session II. Electrical Therapies for CHF Moderators: William T. Abraham, Stefan Anker Discussants: Robin E. Germany, Spencer H. Kubo, Kimberly Selzman 1:15 pm - CRT Applicability in Key Subgroups: Earlier (NYHA I/II), Later (NYHA IV), and Female Patients Kimberly Selzman 1:25 pm - BioControl Spencer H. Kubo 1:35 pm - Respicardia Robin E. Germany 1:45 pm - Discussion with Q&A Session III. Progress with Ventricular Assist Devices Moderators: Eric A. Rose, Richard Smalling Discussants: Keith D. Aaronson, William T. Abraham, Henning Rud Andersen, Robert D. Dowling, Robert E. Michler, Leslie W. Miller, John O Connell 1:55 pm - Background Medical and Device Therapies for Patients with VADs Emma Birks 2:05 pm - REVIVE-IT Keith D. Aaronson 2:15 pm - ROADMAP John O Connell 2:25 pm - Counterpulsation for Chronic Heart Failure: Sunshine William T. Abraham 2:35 pm - CircuLite for Patients with INTERMACS 4, 5, and 6 Leslie W. Miller 2:45 pm - Autologous Cardiac Stem Cells in VAD Patients Robert E. Michler 2:55 pm - SynCardia Marvin J. Slepian 3:05 pm - Counterpulsation with SYMPHONY for Chronic Heart Failure Robert D. Dowling 3:15 pm - pvads in Cardiogenic Shock Mark B. Anderson 3:25 pm - Thoratec Percutaneous Heart Pump Juan F. Granada 3:35 pm - Discussion with Q&A Session IV. Anatomic Abnormalities of the Valve and the LV Chamber Moderators: JoAnn Lindenfeld, Robert J. Siegel Discussants: Stephan Baldus, Robert E. Michler, Martyn R. Thomas 3:50 pm - Overview: Addressing Structure in Structural Heart Disease Robert E. Michler 4:00 pm - First Report of a Confirmatory (Cohort B) Study of the Parachute Device in Ischemic Dilated Cardiomyopathy Martyn R. Thomas 4:10 pm - BioVentrix Minimally Invasive Reshaping of the Anterior Infarcted Heart Lon S. Annest 4:20 pm - MitraClip in Patients with CHF Stephan Baldus 4:30 pm - Discussion with Q&A Session V. Heart Failure with Preserved Ejection Fraction (HFPEF) Moderators: Ileana L. Pina, Jay S. Yadav Discussants: Ted E. Feldman, Mitchell W. Krucoff, William C. Little 4:40 pm - HFPEF: Overview of Pathophysiology and Therapies William C. Little 4:50 pm - DC Devices: Interatrial Shunt for HFPEF Ted E. Feldman 5:00 pm - CVRx: Results in Heart Failure William C. Little 5:10 pm - CorAssist Mitchell W. Krucoff 5:20 pm - Discussion with Q&A Session VI. Cellular and Noncellular Implants for Heart Failure Moderators: Daniel Burkhoff, Bernard J. Gersh Discussants: Jozef Bartunek, Timothy D. Henry 5:30 pm - Overview 1: Biological Therapies for Heart Failure: Clinical Perspectives and Progress Timothy D. Henry 5:40 pm - Overview 2: Biological Therapies for Heart Failure: Regulatory Perspectives Steve Winitsky 5:50 pm - Post-MI Alginate to Prevent Remodeling Mitchell W. Krucoff 6:00 pm - Discussion with Q&A 6:00 pm - Adjourn Launching and Sustaining Your Career 1:00 pm-6:00 pm Room A This session is only CME accredited. Session I. Early Success Begets Success Moderator: Pamela S. Douglas Discussants: J. Dawn Abbott, Nirat Beohar, David J. Cohen, Lynn F. Peng, Thomas M. Tu, Howard T. Walpole 1:00 pm - Contracts 101 Thomas M. Tu 1:35 pm - Payment Reform: Prepare for the Changes Pamela S. Douglas 2:00 pm - Lifelong Learning and Staying Abreast of the Literature J. Dawn Abbott 2:15 pm - The CV Service Line: Patients, Products, and Referrals Howard T. Walpole 2:40 pm - Discussion with Q&A Session II. High Career Achievement Moderator: Paul Sorajja Discussants: Navin K. Kapur, Norman E. Lepor, Srihari S. Naidu, Jennifer A. Tremmel, Howard T. Walpole 3:10 pm - Post-Fellowship Skill Training: Proctoring and Beyond Paul Sorajja 3:35 pm - The Physician Executive: Do I Need an MBA or Not? Howard T. Walpole 4:00 pm - Emotional Intelligence and Crucial Conversations Jennifer A. Tremmel 4:25 pm - Leadership Pathways in National Societies Srihari S. Naidu 4:50 pm - Discussion with Q&A 6:00 pm - Adjourn Left Atrial Appendage Closure: Indications, Devices, and Techniques 1:00 pm-6:13 pm Room B Session I. LAA Closure: Emerging Data Moderators: Peter Sick, Horst Sievert Discussants: Peter C. Block, A. Marc Gillinov, Saibal Kar, Jai-Wun Park, Vivek Y. Reddy, Mark Reisman Tuesday - October 23,

112 Tuesday, October 23 1:00 pm - Various Techniques for Surgical LAA Closure (With and Without Thoracoscopy): Acute and Long-term Outcomes A. Marc Gillinov 1:08 pm - Long-term Results from PROTECT AF: Is the Risk-Benefit Ratio Really Uncertain? David R. Holmes Jr 1:16 pm - Prevail Study: Design and Current Status Saibal Kar 1:21 pm - Outcomes and Insights from the European ACP Registry Jai-Wun Park 1:29 pm - The Spectrum of Early Complications of LAA Closure: Have They Been Eliminated? David R. Holmes Jr 1:37 pm - Epicardial LAA Closure with the LARIAT (SentreHEART): Simple, Safe, and Effective? Mark Reisman 1:45 pm - LAA Closure in Anticoagulation Contraindicated Patients: The ASAP Trial and Beyond Horst Sievert 1:53 pm - The Spectrum of Late Complications of LAA Closure: Device-Specific Mechanisms, Incidence, and Prevention Peter C. Block 2:01 pm - Quality-of-Life and Cost- Effectiveness After LAA Closure Vivek Y. Reddy 2:09 pm - Discussion with Q&A Session II. Weighing the Risks and Benefits of Therapeutic Alternatives Moderators: Peter C. Block, Brian K. Whisenant Discussants: Shephal Doshi, Roxana Mehran, Peter Sick, Gregg W. Stone 2:23 pm - Modeling the Risk of Stroke and Bleeding in Atrial Fibrillation: What Are the Optimal Risk Scores? Roxana Mehran 2:33 pm - Synthesis of the New ESC LAA Closure Guidelines Peter Sick 2:43 pm - The New Anticoagulants: A Meaningful Step Forward? Gregg W. Stone 2:53 pm - Acute Success Rates, Complication, and Long-term Stroke Risks After AF Ablation: A Critical Appraisal of a Mixed Literature Shephal Doshi 3:03 pm - Discussion with Q&A Session III. Imaging for LAA Closure Moderators: Saibal Kar, Vivek Y. Reddy Discussants: Rebecca Tung Hahn, Ilona Hoffmann, Carlos E. Ruiz 3:13 pm - A Primer of LAA Closure Imaging: Essential Views and Pattern Recognition Rebecca Tung Hahn 3:23 pm - 2-D TEE, 3-D TEE, and Fluoro-Echo Overlay: What Is Essential and What Is Nice to Have? Ilona Hoffmann 3:33 pm - CT and MRI for Patient Selection and Procedural Guidance Carlos E. Ruiz 3:43 pm - ICE Guidance for LAA Closure: Advantages and Limitations Vivek Y. Reddy 3:53 pm - Discussion with Q&A Session IV. Evolution of LAA Closure Devices Moderators: David R. Holmes Jr, Carlos E. Ruiz Discussants: Alexander J. Javois, Yat-Yin Lam, Vivek Y. Reddy, Peter Sick, Horst Sievert 4:03 pm - Attributes of the Perfect LAA Closure Device: What All the Companies Should Strive For Horst Sievert 4:13 pm - The New Fourth-Generation WATCHMAN (BSC-Atritech): Device Design and Results of the EVOLVE Trial Vivek Y. Reddy 4:23 pm - WaveCrest (Coherex Medical): Device Iteration, Human Outcomes, and Clinical Trial Directions Saibal Kar 4:33 pm - PFM Medical: Device Description and Preclinical Results Alexander J. Javois 4:38 pm - Lifetech LAA Closure Device: Description and Preclinical Results Yat-Yin Lam 4:43 pm - Cardia LAA Closure Device: Description and Preclinical Results Juan F. Granada 4:48 pm - Discussion with Q&A Session V. LAA Closure Tips and Tricks Moderators: Josep Rodes-Cabau, Robert J. Sommer Discussants: Steven L. Almany, Maurice Buchbinder, Brij Maini, David W.M. Muller, Matthew J. Price, Ramon Quesada, Gerhard C. Schuler, Zoltan G. Turi 4:58 pm - WATCHMAN Tips and Tricks Peter Sick 5:08 pm - Case Presentation: A Complicated WATCHMAN Case Horst Sievert 5:18 pm - ACP Tips and Tricks David W.M. Muller 5:28 pm - Case Presentation: A Complicated ACP Case Jai-Wun Park 5:38 pm - LARIAT Tips and Tricks Steven J. Yakubov 5:48 pm - Case Presentation: A Complicated LARIAT Case Randall J. Lee 5:58 pm - How to Become Trained and Start a LAA Closure Program Brian K. Whisenant 6:13 pm - Adjourn Next-Generation DES and Bioabsorbable Scaffolds 1:00 pm-6:07 pm Hall A-Coronary Theater This session is only CME accredited. Session I. The Potential for Novel Technologies Moderators: Juan F. Granada, Robert S. Schwartz Discussants: Nicolas A.F. Chronos, Joost Daemen, Keith D. Dawkins, Michael Joner, Charles A. Simonton, Josiah N. Wilcox 1:00 pm - Current Perspectives on DES Outcomes: Is There a Clinical Need for Development of Next Generation DES Systems? Stephan Windecker 1:08 pm - Balancing Device Polymeric Load and Long-term Absorption Will Result in the Ideal DES Platform: Bioresorbable Vascular Scaffolds Are the Future! Jean-François Tanguay 1:16 pm - Strut Architecture and Polymer Configuration Modulates Device Outcomes: Current Nonabsorbable DES Systems Will Be Difficult to Improve Upon! Elazer R. Edelman 1:24 pm - Early Cellular Interaction and Biomaterials: Bioabsorbable Polymers and Advanced Metallic Surfaces Are the Next Logical Step! Juan F. Granada 1:32 pm - Vascular Healing and the Evolution of DES Technologies: Pathology Insights from Human Specimens Renu Virmani 1:40 pm - Discussion with Q&A 110

113 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics Session II. Metallic Drug-Eluting Stents with Bioabsorbable Polymers Moderators: Dean J. Kereiakes, Alan C. Yeung Discussants: Marco A. Costa, Yaling Han, Chaim S. Lotan, Simon Walsh, Bo Xu 1:52 pm - Synergy (Boston Scientific) Program Update Ian T. Meredith 2:02 pm - TARGET I: A Prospective, Randomized Trial of a Biodegradable Polymer-based Sirolimus-Eluting Stent vs an Everolimus-Eluting Stent (MicroPort) Run-Lin Gao 2:09 pm - DESSOLVE II: A Prospective, Randomized Trial of a Biodegradable Polymer-based Sirolimus-Eluting Stent vs a Zotarolimus-Eluting Stent (Micell) David E. Kandzari 2:16 pm - Orsiro (BIOTRONIK) Program Update Stephan Windecker 2:23 pm - BioMime (Meril Life Sciences) Program Update Ashok Seth 2:30 pm - Abluminus (Envision Scientific) Program Update Sameer I. Dani 2:37 pm - REMEDEE Combo (OrbusNeich) Program Update Michael Haude 2:44 pm - DESyneBD (Elixir Medical) Program Update Ricardo A. Costa 2:51 pm - Inspiron (Scitech) Program Update Pedro A. Lemos 2:58 pm - Sirolimus-Eluting Stent (Svelte Medical) Program Update Mark W.I. Webster 3:05 pm - Discussion with Q&A Session III. Polymer-Free Metallic Drug-Eluting Stents Moderators: Raimund A. Erbel, Philip M. Urban Discussants: Vinay K. Bahl, Graham A. Cassel, Ricardo A. Costa, Giulio Guagliumi, John M. Lasala, Daniel I. Simon 3:20 pm - Yukon (Translumina) Program Update Julinda Mehilli 3:30 pm - Cre8 (CID) Program Update Didier Carrié 3:37 pm - BioFreedom (Biosensors International) Program Update Philip M. Urban 3:44 pm - Amazonia Pax (MINVASYS) Program Update Jean Fajadet 3:51 pm - VESTAsync (MIV Therapeutics) Program Update Ricardo A. Costa 3:56 pm - Nanoparticle-Based Stents 1: Mitsui (Meril Life Sciences) Program Update Ricardo A. Costa 4:01 pm - Nanoparticle-Based Stents 2: FOCUS np (Envision Scientific) Program Update Ashok Seth 4:06 pm - Progress with a Hollow-Core Zotarolimus-Filled Stent (Medtronic) Josiah N. Wilcox 4:11 pm - Discussion with Q&A Session IV. Bioresorbable Vascular Scaffolds: Latest Designs and Clinical Study Evidence Moderators: Dean J. Kereiakes, Ron Waksman Discussants: Adrian P. Banning, Stephen G. Ellis, Jacques J. Koolen, Detlef G. Mathey, Yoshinobu Onuma, Jean-François Tanguay 4:26 pm - ABSORB (Abbott Vascular) Program to Date: Integrated Insights from Multimodality Imaging Patrick W. Serruys 4:38 pm - Vasomotion After Metallic and Bioabsorbable Implants: Evaluation and Clinical Relevance Ian T. Meredith 4:45 pm - ABSORB (Abbott Vascular) Clinical Program to Date (Including the Six-Month EXTEND Results): Strengths, Limitations, and Unknowns of the ABSORB Stent Antonio L. Bartorelli 4:57 pm - Can BVS Be Used in Complex Coronary Anatomy? A Series of Case Presentations Antonio Colombo 5:07 pm - ABSORB III and IV (Abbott Vascular) Pivotal Clinical Trial Program Gregg W. Stone 5:12 pm - ReZolve (REVA Medical) Clinical Program Update Ricardo A. Costa 5:22 pm - First-in-Man Results with a Myolimus-Eluting Bioabsorbable PLLA- Based Vascular Scaffold (Elixir DESolve) Stefan Verheye 5:32 pm - Progress with Drug-Eluting Magnesium Resorbing Stents (BIOTRONIK): DREAMS 2-Year Results Michael Haude 5:42 pm - The ART Stent: Design and Early First-in-Man Experiences Jean Fajadet 5:47 pm - The Amaranth Stent: Design and Future Directions Juan F. Granada 5:52 pm - Design of a Fully Drug-Eluting Bioabsorbable Scaffold with EPC-Capture Technology Robert J. Cottone 5:57 pm - Discussion with Q&A 6:07 pm - Adjourn The Valvular Heart Disease Summit (Part 2): Mitral Valve Therapies 1:00 pm-6:21 pm Hall A-Structural and Endovascular Theater Session I. Standards and Global Practices Moderators: Blase A. Carabello, Francesco Maisano Discussants: James S. Gammie, Robert A. Guyton, Gregg W. Stone 1:00 pm - The 2012 ESC Mitral Valve Guidelines: What s New, and How Should They Affect Practice? Francesco Maisano 1:10 pm - Practice Trends in the United States: Nonadherence to the Mitral Valve Guidelines James S. Gammie 1:20 pm - The Mitral VARC Initiative Gregg W. Stone 1:25 pm - Discussion with Q&A Session II. Mitral Valve Anatomy and Imaging Moderators: Rebecca Tung Hahn, Neil J. Weissman Discussants: David H. Adams, Jeroen J. Bax, Paul A. Grayburn, Maurice E. Sarano, Robert J. Siegel, Nina C. Wunderlich 1:35 pm - New Insights into Normal and Diseased Mitral Valve Anatomy David H. Adams 1:45 pm - Essentials of 2-D and 3-D Mitral Valve Imaging Nina C. Wunderlich 1:55 pm - Rationale for Quantitative Echocardiography to Grade MR Severity and a Critical Appraisal of Its Accuracy and Utility Paul A. Grayburn 2:05 pm - Imaging the Mitral Valve: Beyond Echo Jeroen J. Bax 2:15 pm - Discussion with Q&A Tuesday - October 23,

114 Tuesday, October 23 Instructive Debate 1. Should the Definition of Severe MR Be Different for Functional and Degenerative MR? 2:25 pm - Yes: The Quantitative Threshold Should Be Lowered! Maurice E. Sarano 2:33 pm - No: Changing Standards Would Be Premature! Robert J. Siegel 2:41 pm - Case Example: How Severe Is the MR in this Patient? Rebecca Tung Hahn 2:49 pm - Discussion with Q&A Session III. Functional Mitral Regurgitation: Diagnosis and Treatment Moderators: Michael J. Mack, Mark Reisman Discussants: Stefan Anker, Michael Argenziano, Steven F. Bolling, Ted E. Feldman, Karl-Heinz Kuck, D. Craig Miller, Patrick T. O Gara, Sonna M. Patel-Raman, Jason H. Rogers, Allan Schwartz, Gregg W. Stone 2:57 pm - Functional MR Due to Idiopathic vs. Ischemic Cardiomyopathy (and Due to Anterior vs. Posterior Infarction): Similarities and Differences Blase A. Carabello 3:05 pm - Do Beta Blockade, Afterload Reduction, and Other Medical Therapies Improve Prognosis in Functional MR? Review of the Literature and Practical Recommendations Jason H. Rogers 3:13 pm - CRT in the Management of the Patient with Heart Failure and Severe MR William T. Abraham 3:23 pm - MR with Normal Left Ventricular Ejection Fraction: What Is It and How Should It Be Treated? Patrick T. O Gara 3:31 pm - Varying Annuloplasty Rings and Nonannuloplasty Surgical Approaches for Ischemic MR: Do They Make a Difference? D. Craig Miller 3:41 pm - Discussion with Q&A Instructive Debate 2: What Is Standard of Care for the Treatment of Severe Functional MR? 3:51 pm - Follow the (Lack of) Evidence: Medical Therapy and CRT! Allan Schwartz 3:56 pm - Few Patients with Functional MR Are Treated Surgically: Duke Database Results Mitchell W. Krucoff 4:01 pm - Surgery Is the Obvious Choice! Steven F. Bolling 4:06 pm - The MitraClip Has an Important Role to Play! Ted E. Feldman 4:11 pm - FDA View on Standard of Care for Functional MR Sonna M. Patel-Raman 4:16 pm - Discussion with Q&A New Trials in Functional MR 4:25 pm - CTSN Trials: Rationale and Status Michael Argenziano 4:33 pm - COAPT Gregg W. Stone 4:38 pm - RESHAPE Karl-Heinz Kuck 4:43 pm - Discussion with Q&A Session IV. When Mitral Surgery Fails Moderators: Scott Lim, Jason H. Rogers Discussant: Francesco Maisano 4:51 pm - Valve-in-Valve and Valve-in-Ring Experiences Francesco Maisano 5:06 pm - Discussion with Q&A Session V. Additional MitraClip Considerations Moderators: Stephan Baldus, Ted E. Feldman, Saibal Kar Discussants: Paul A. Grayburn, Francesco Maisano, Michael J. Rinaldi, Hendrik Treede 5:12 pm - MitraClip Registries: ACCESS-EU, GERMAN Registry, ESC Registry, High-Risk Registry, and REALISM: What Have We Learned Recently? Francesco Maisano 5:27 pm - When Should the MitraClip Be Considered for Front-Line Therapy of Degenerative MR? Michael J. Rinaldi 5:37 pm - Imaging Guidance for MitraClip Eligibility and Implantation: Top 10 Tips and Tricks Paul A. Grayburn 5:47 pm - Two MitraClip Case Surprises: One in Whom It Worked and One in Whom It Didn t Stephan Baldus 5:59 pm - Surgical Perspectives of the MitraClip and Its Role in the Treatment of Severe Degenerative and Functional MR Hendrik Treede 6:09 pm - Discussion with Q&A 6:21 pm - Adjourn Transradial Angiography and Intervention: From Basic to Advanced 1:00 pm-6:00 pm Room A Session I. Transradial Basics Moderators: Martial Hamon, Varinder P. Singh Discussants: Douglas G. Fraser, Samir B. Pancholy, Tejas Patel, Kimberly A. Skelding, Jennifer A. Tremmel 1:00 pm - From Access to the Coronaries: Strategies for Success and Troubleshooting Douglas G. Fraser 1:15 pm - Diagnostic and Guide Catheter Selection and Manipulation Varinder P. Singh 1:25 pm - Radial Artery Hemostasis and Occlusion Samir B. Pancholy 1:35 pm - Complications of the Radial Approach: Frequency, Prevention, and Management Tejas Patel 1:50 pm - Radial Artery Patency After Transradial Angiography and Intervention: The Next Open Artery Hypothesis? Zoltan G. Turi 2:00 pm - Discussion with Q&A Session II. Acute Coronary Syndromes, Antithrombotic Therapy, and Radial Access Moderators: Olivier F. Bertrand, Shamir R. Mehta Discussants: Robert J. Applegate, Ivo Bernat, Philippe Garot, Luis A. Guzman, James B. Hermiller Jr 2:15 pm - Radial Approach and Reduced Mortality: Causal or Confounding? Olivier F. Bertrand Transradial Primary PCI Debate 2:25 pm - Believe the Data! Radial Approach for Primary PCI Is Preferred! Shamir R. Mehta 2:35 pm - Radial Approach Offers No Benefit Over Femoral Plus Bivalirudin! James B. Hermiller Jr 2:45 pm - Radial Approach for NSTEMI: Case Closed or Worth Changing Practice? Robert J. Applegate 3:00 pm - Discussion with Q&A Session III. Transradial Science Moderators: Yves R. Louvard, Tejas Patel Discussants: Olivier F. Bertrand, Ian C. Gilchrist, Martial Hamon, Yuji Ikari, Shamir R. Mehta, James Nolan, Christopher Pyne, Ramon Quesada 112

115 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics 3:15 pm - Highlights of the Radial Literature from the Past Year Olivier F. Bertrand 3:30 pm - Antithrombotic Strategies in Patients on Chronic Oral Anticoagulation Ramon Quesada 3:45 pm - Radial Circulation: Do We Need to Check for Dual Circulation of the Hand Before Accessing the Radial Artery? Ian C. Gilchrist 4:00 pm - Is There a Higher Risk of Stroke With the Radial Approach? Reasons and Results Martial Hamon 4:15 pm - Miniaturization: The Future of Transradial? Yuji Ikari 4:30 pm - Discussion with Q&A Tuesday - October 23, 2012 Session IV. Transradial Intervention: Operational and Policy Issues Moderators: Olivier F. Bertrand, Sunil V. Rao Discussants: Sanjit S. Jolly, Jose L. Leiva-Pons, Yves R. Louvard, Duane S. Pinto, Adhir Shroff 4:45 pm - Transradial Learning Curve: What Does It Take to Become Proficient? Yves R. Louvard 5:00 pm - Economics of the Radial Approach: Do the Older Data Still Apply Today? Duane S. Pinto 5:15 pm - Vascular Access Choice and Radiation Exposure Sanjit S. Jolly 5:30 pm - Same-Day Discharge After Radial PCI: Protocols and Practice Sunil V. Rao 5:45 pm - Discussion with Q&A 6:00 pm - Adjourn Evening Programs 7:00 pm-8:30 pm Please see page 166 for the Evening Programs schedule

116 CARDIOVASCULAR RESEARCH FOUNDATION Skirball Research Center Redefining Preclinical Cardiovascular Translational Research The CRF Skirball Research Center is a state-of-the-art facility dedicated to the investigation of novel concepts, treatments, and devices. Our team of interventionalists, surgeons, and pathologists guide early ideas and inventions through comprehensive research programs in order to introduce practical clinical therapies to patients. The CRF Skirball Research Center is the starting point for technological advances that will ultimately improve the lives of those suffering from cardiovascular disease and is defined by innovative thinking. Research Cores Contact us: Tel: [email protected] Interventional vascular biology Applied cardiovascular imaging Regenerative interventional therapies Structural heart disease Interventional pharmalogy Visit us at booth 596 located in the Exhibit Hall. CARDIOVASCULAR RESEARCH FOUNDATION a passion for innovation

117 Breakfast Meetings Main Arena How to Treat Theater: Coronary Artery Disease How to Treat Theater: Structural Heart and Endovascular Disease International Multiplex Theater Challenging Case Theater Challenging Case Theater Maintenance of Certification (MOC) Course Special Sessions Japan-US Synergies in Global Medical Device Innovation: Harmonization by Doing (HBD) at TCT Edited Taped Case Presentations Challenging Case Video Presentations Presentation Theater TCT: An Integrated Course for Surgeons and Interventionalists , 132 Morning Spotlight Sessions Deep Dive: Stroke Prevention Therapies From Clinical Trial Evidence to Clinical Practice: Unraveling the Issues Innovative Surgical Techniques and Technologies Next-Generation Transcatheter Mitral Valve Therapies The Use and Abuse of Appropriate Use Criteria (AUC): A Case-Based Tutorial Lunchtime Activities Hot Topics Learn the Technique Challenging Case Video Presentations Afternoon Spotlight Sessions Wednesday October 24, 2012 Miami Beach Convention Center miami, FL Deep Dive: Hypertension and Renal Artery Denervation Next-Generation Transcatheter Aortic Valve Therapies Optimizing Use of Today s Antithrombotic and Antiplatelet Drugs in ACS and PCI Surgical, Interventional, and Hybrid Procedures (Part 2): Valvular and Structural Heart Disease The Skeptic s Corner: Controversies in Interventional Cardiology Evening Programs The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics

118 Wednesday, October Breakfast Meetings 7:00 am-8:00 am Please see page 168 for the Breakfast Meeting schedule. Main Arena 8:00 am-6:00 pm Hall D Plenary Session I. Live Cases I Live Case Moderator: Gregg W. Stone Live Case Co-Moderators: Martin B. Leon, Martyn R. Thomas Live Case Discussants: Rafael Beyar, Bernard R. Chevalier, Alaide Chieffo, Carlo Di Mario, Anthony H. Gershlick, Carey D. Kimmelstiel, Michael J. Mack, Nicolo Piazza, Simon Redwood, Charanjit S. Rihal, Ron Waksman, Patrick L. Whitlow 8:00 am - NewYork-Presbyterian Hospital/ Columbia University Medical Center 8:45 am - Shaare Zedek Medical Center Jerusalem, Israel Plenary Session II. Welcome and Introduction to TCT 2012 Moderators: Martin B. Leon, Gregg W. Stone 9:30 am - Welcome to TCT 2012! Plenary Session III. A Memorial to Geoffrey O. Hartzler, MD Moderators: Martin B. Leon, Gregg W. Stone Discussants: Bonnie Brown, Howard A. Cohen, Antonio Colombo, Gary Curtis, Lee Giorgi, David R. Holmes Jr, Bob Jackson, Warren L. Johnson, Joel Kahn, Martin B. Leon, Barry D. Rutherford, Shigeru Saito, Patrick W. Serruys, William N. Starling, Dave Strelow 9:35 am - Introduction to an Extraordinary Life Gregg W. Stone 9:40 am - Geoff Hartzler... in His Own Words: A Video Tribute 9:58 am - Discussion: Personal Remembrances Moderator: Gregg W. Stone Plenary Session IV. TCT 2012 Geoffrey O. Hartzler Master Operator Award Moderators: Martin B. Leon, Gregg W. Stone 10:20 am - Presentation of the Geoffrey O. Hartzler Master Operator Award Award Presenter: Gregg W. Stone Award Recipient: Barry D. Rutherford Plenary Session V. TCT 2012 Game-Changing Therapies I. The Hottest New Interventional Therapy: Renal Denervation for Refractory Hypertension Moderators: William W. O Neill, Krishna J. Rocha-Singh Discussants: Andreas Baumbach, Deepak L. Bhatt, Michael Böhm, Justin E. Davies, Felix Mahfoud, James R. Margolis, Klaus D. Mathias, C. Venkata S. Ram, Horst Sievert, Paul A. Sobotka 10:30 am - Renal Sympathetic Denervation as the Ideal Target for Refractory Hypertension: Anatomy and Pathophysiology Michael Böhm 10:40 am - What s Known and Not Known About Renal Denervation for Hypertension: Critical Appraisal of the Clinical Data Deepak L. Bhatt 10:50 am - Catheter-Based Technology Alternatives for Renal Denervation Horst Sievert 11:00 am - Beyond Hypertension: Future Prospects for Renal Denervation Therapy Paul A. Sobotka 11:10 am - Discussion Plenary Session VI. Late Breaking Trials I Moderator: Martin B. Leon Co-Moderator: Antonio Colombo Discussants: David J. Cohen, Cindy L. Grines, Jose P.S. Henriques, Spencer B. King III, Jacques J. Koolen, Simon Redwood, Habib Samady, Philippe Gabriel Steg, Holger Thiele, Harvey D. White, Stephan Windecker 11:20 am - FAME 2 Cost-effectiveness: A Prospective, Randomized Trial Evaluating the Cost-effectiveness of FFR-Guided PCI in Patients with Stable Coronary Artery Disease William F. Fearon 11:32 am - Discussion 11:40 am - MASTER: A Prospective, Randomized Trial of a PET Micronet Mesh-Covered Stent vs. Standard Stents in Patients with ST- Segment Elevation Myocardial Infarction Gregg W. Stone 11:52 am - Discussion 12:00 pm - ISAR-LEFT MAIN 2: A Prospective, Randomized Trial of Everolimus-Eluting vs. Zotarolimus-Eluting Stents in Patients with Unprotected Left Main Disease Julinda Mehilli 12:12 pm - Discussion Plenary Session VII. First Report Investigations I Moderator: Stephan Windecker Discussants: Sheldon Goldberg, Karel T. Koch, Karl-Heinz Kuck, Roger J. Laham, Jan J. Piek, Manel Sabate, Peter C. Smits, Gerald S. Werner 12:20 pm - PARTNER Cohort B Three Year: Clinical and Echocardiographic Outcomes from a Prospective, Randomized Trial of Transcatheter Aortic Valve Replacement in Inoperable Patients Samir R. Kapadia 12:30 pm - Discussion 12:35 pm - TRILOGY ACS Angiographic Cohort: A Prospective, Randomized Trial of Prasugrel vs. Clopidogrel in Patients with Non-ST-Segment Elevation ACS Who Are Medically Managed After Coronary Angiography Stephen D. Wiviott 12:45 pm - Discussion 12:50 pm - A Prospective, Randomized Trial of Nitinol Stents vs. Balloon Angioplasty in Obstructive Popliteal Lesions Thomas Zeller 1:00 pm - Discussion Plenary Session VIII. Live Cases II Live Case Moderator: Martin B. Leon Live Case Co-Moderator: Eberhard Grube Live Case Discussants: Deepak L. Bhatt, Giancarlo Biamino, Edoardo Camenzind, Roger M. Greenhalgh, Kishore J. Harjai, Zvonimir Krajcer, John R. Laird Jr, Azeem Latib, Bernhard Reimers, Bruno Scheller, Craig M. Walker 1:00 pm - Baptist Cardiac and Vascular Institute Miami, FL 1:45 pm - Instituto Dante Pazzanese de Cardiologia São Paulo, Brazil

119 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics Plenary Session IX. Coronary Revascularization Highlights Moderators: David R. Holmes Jr, A. Pieter Kappetein Discussants: Rory Hachamovitch, David J. Maron, Laura Mauri, Manesh R. Patel, Patrick W. Serruys, Gregg W. Stone, David Taggart, William S. Weintraub, Robert L. Wilensky 2:30 pm - The Forgotten Art of Advanced Medical Therapy: The Case for a Conservative Approach in Managing Coronary Disease William S. Weintraub 2:45 pm - Advanced Directive: Treat Only Ischemia-Producing Lesions! The Mandate for Functional Guidance Before or During PCI Rory Hachamovitch 3:00 pm - Evolutionary Revascularization Strategies for Coronary Artery Disease: From Anatomy to Ischemia to Vulnerable Plaque Gregg W. Stone 3:15 pm - Discussion Plenary Session X. Live Cases III Live Case Moderator: Martin B. Leon Live Case Co-Moderator: James B. Hermiller Jr Live Case Discussants: Charles J. Davidson, Adam J. de Belder, Petr Kala, Ran Kornowski, Gary S. Mintz, Michael Mooney, Massimo Napodano, Barry D. Rutherford, Joachim Schofer, Vinod H. Thourani, Jochen Wöhrle 3:30 pm - St. Paul s Hospital/University of British Columbia Vancouver, Canada 4:15 pm - Scripps Green Hospital La Jolla, CA Plenary Session XI. Endovascular Horizons Moderators: Jeffrey W. Olin, Christopher J. White Discussants: Gary M. Ansel, L. Nelson Hopkins, John R. Laird Jr, Reginald I. Low, Philip M. Meyers, Jacques Moret, Stephen R. Ramee, Jason H. Rogers, James P. Zidar 5:00 pm - Interventional Stroke Therapy: Unraveling the Gordian Knot Jacques Moret 5:15 pm - Endovascular Management of Erectile Dysfunction: Overview and Future Potential Jason H. Rogers 5:30 pm - A Visionary Roadmap for Endovascular Intervention: Growth Opportunities and Probing the Known and the Unknown Barry T. Katzen 5:45 pm - Discussion 6:00 pm - Adjourn How to Treat Theater: Coronary Artery Disease 7:50 am-6:00 pm Hall A-Coronary Theater This session is only CME accredited. Left Main and Bifurcation Intervention I Moderator: Yves R. Louvard Co-Moderator: David G. Rizik 8:00 am - Left Main PCI vs. CABG Today: A Guide to Clinical Decision Making Patrick W. Serruys 8:15 am - Technical Considerations for Left Main Intervention: From Stent Strategies to Imaging Guidance to Staging and Hemodynamic Support David J. Hildick-Smith Live Cases: Left Main and Bifurcation Intervention I Live Case Moderator: Yves R. Louvard Live Case Co-Moderator: David G. Rizik Live Case Discussants: Amr Abbas, Takashi Akasaka, David Antoniucci, James C. Blankenship, Francesco Burzotta, Charles Chan, Marco A. Costa, Andrejs Erglis, Dietmar H. Glogar, Masato Nakamura 8:30 am - Ferrarotto Hospital Catania, Italy 9:30 am - Mount Sinai Medical Center Miami, FL Left Main and Bifurcation Intervention II Moderator: George D. Dangas Co-Moderator: Seung-Jung Park 10:30 am - Bifurcation Lesion Stenting: Impact of Stent Geometry and Technique on Outcomes (and Potential of Dedicated Bifurcation Stents) John A. Ormiston 10:45 am - An Algorithmic Approach for (Non-Left Main) Bifurcation Stenting Based on Lesion Anatomy Issam D. Moussa Live Cases: Left Main and Bifurcation Intervention II Live Case Moderator: Roxana Mehran Live Case Co-Moderator: Seung-Jung Park Live Case Discussants: Adrian P. Banning, Antonio L. Bartorelli, Davide Capodanno, Shao Liang Chen, Fernando Cura, Nicolas Foin, Liliana R. Grinfeld, Michael S. Lee, Julinda Mehilli 11:00 am - Shaare Zedek Medical Center Jerusalem, Israel 12:00 pm - Instituto Dante Pazzanese de Cardiologia São Paulo, Brazil CTO Intervention I Moderator: J. Aaron Grantham Co-Moderator: Etsuo Tsuchikane 1:00 pm - CTO Antegrade Intraluminal and Reentry Techniques: Didactic Review William L. Lombardi 1:15 pm - CTO Antegrade Intraluminal and Reentry Techniques: A Series of Illustrative Cases J. Aaron Grantham Live Cases: CTO Intervention I Live Case Moderator: J. Aaron Grantham Live Case Co-Moderator: Etsuo Tsuchikane Live Case Discussants: Yasushi Asakura, Ronald Caputo, Richard R. Heuser, Jonathan M. Hill, Angela Hoye, Kazuaki Mitsudo, Sudhir Rathore, Jonathan S. Roberts, Shigeru Saito, Georgios Sianos 1:30 pm - Scripps Green Hospital La Jolla, CA 2:30 pm - Scripps Green Hospital La Jolla, CA CTO Intervention II Moderator: William L. Lombardi Co-Moderator: Osamu Katoh 3:30 pm - CTO Retrograde Techniques: Didactic Review Masahiko Ochiai 3:45 pm - CTO Retrograde Techniques: A Series of Illustrative Cases Osamu Katoh Wednesday - October 24,

120 Wednesday, October Live Cases: CTO Intervention II Live Case Moderator: William L. Lombardi Live Case Co-Moderator: Osamu Katoh Live Case Discussants: Carlo Briguori, Mauro Carlino, Kenneth Chin, Yasuhiro Honda, Keiichi Igarashi, Manish A. Parikh, Satoru Sumitsuji, R. Michael Wyman, Masahisa Yamane 4:00 pm - Piedmont Heart Institute Atlanta, GA 5:00 pm - Piedmont Heart Institute Atlanta, GA 6:00 pm - Adjourn How to Treat Theater: Structural Heart and Endovascular Disease 8:00 am-6:00 pm Hall A-Structural and Endovascular Theater This session is only CME accredited. Transcatheter Valve Therapies I Moderator: Josep Rodes-Cabau Co-Moderator: Victor Guetta 8:00 am - Patient Selection for TAVR: Risk Stratification, Important Patient Subgroups, and the Heart Team Scott Lim 8:15 am - Patient Selection for the MitraClip: Clinical vs. Anatomic Considerations, and Diagnosis of Severe MR Robert J. Siegel Live Cases: Transcatheter Valve Therapies I Live Case Moderator: Josep Rodes-Cabau Live Case Co-Moderator: Victor Guetta Live Case Discussants: Bruce Bowers, Raimund A. Erbel, Philippe Généreux, Brad I. Munt, Amit Segev, Kimberly A. Skelding, Terje K. Steigen, Konstantinos Toutouzas, George W. Vetrovec 8:30 am - Instituto Dante Pazzanese de Cardiologia São Paulo, Brazil 9:30 am - NewYork-Presbyterian Hospital/ Columbia University Medical Center Transcatheter Valve Therapies II Moderator: Martyn R. Thomas Co-Moderator: Raoul Bonan 10:30 am - Clinical Outcomes After TAVR: Risks vs. Benefits Martyn R. Thomas 10:45 am - Clinical Outcomes After MitraClip: Risks vs. Benefits (in FMR vs. DMR) Howard C. Herrmann Live Cases: Transcatheter Valve Therapies II Live Case Moderator: Martyn R. Thomas Live Case Co-Moderator: Raoul Bonan Live Case Discussants: Lutz Buellesfeld, Haim Danenberg, Jan Harnek, Neil E. Moat, Augusto D. Pichard, Michael J. Reardon, Konstantinos Spargias, Pieter R. Stella, Peter Wenaweser 11:00 am - St. Paul s Hospital/University of British Columbia Vancouver, Canada 12:00 pm - Ferrarotto Hospital Catania, Italy Iliac and SFA Intervention Moderator: Lawrence A. Garcia Co-Moderator: Erich Minar 1:00 pm - SFA Intervention: State of the Art Today and in 2020 Gary M. Ansel 1:15 pm - Femoropopliteal Atherectomy: A Critical Appraisal Lawrence A. Garcia Live Cases: Iliac and SFA Intervention Live Case Moderator: Lawrence A. Garcia Live Case Co-Moderator: Erich Minar Live Case Discussants: Mark C. Bates, Mark W. Burket, Frank J. Criado, Eric J. Dippel, James D. Joye, R. Stefan Kiesz, Hans Krankenberg, Robert D. Safian, Luigi Salemme 1:30 pm - Park-Krankenhaus Leipzig Leipzig, Germany Renal, Aortic, and Mesenteric Intervention Moderator: Frank J. Criado Co-Moderator: J. Michael Bacharach 3:30 pm - Evolution in Endograft Technology and Applications Eric E. Roselli 3:45 pm - Renal Artery Stenting: What Are the Indications for Intervention in 2012? Christopher J. White Live Cases: Renal, Aortic, and Mesenteric Intervention Live Case Moderator: Frank J. Criado Live Case Co-Moderator: J. Michael Bacharach Live Case Discussants: Max Amor, Jacques Busquet, Tyrone J. Collins, Adrian Ebner, Michel Camille Henry, Thosaphol Limpijankit, Robert A. Lookstein, Mahmood K. Razavi, Mehdi H. Shishehbor 4:00 pm - Baptist Cardiac and Vascular Institute Miami, FL 5:00 pm - Baptist Cardiac and Vascular Institute Miami, FL 6:00 pm - Adjourn International Multiplex Theater These sessions are not CME/CNE accredited. Challenging Case Theater 1 8:00 am-5:00 pm Hall A-IMT 1 TAVR 2012: Unanswered Questions Sponsored by the German Society of Cardiology Working Group on Interventional Cardiology Moderators: Michael Haude, Christoph K. Naber Discussants: Andreas Baumbach, Stephan M. Ensminger, Rudiger Lange, Axel Linke 8:00 am - Case 1: Why I Chose CoreValve for This TAVR Procedure Huseyin Ince 8:15 am - Case 2: Why I Chose Sapien for This TAVR Procedure Axel Linke 8:30 am - Case 3: TAVR for a Degenerated Aortic Bioprosthesis Peter Boekstegers 8:45 am - Case 4: Complication Management During TAVR Ulrich J. Gerckens Complex Approach to Multivessel Disease and Left Main STEMI Sponsored by the Czech Society of Cardiology Working Group on Interventional Cardiology Moderators: Petr Kala, Josef Stasek Discussants: Pavel Cervinka, Martin Mates, Roman Stipal, Josef Veselka, Michael Zelizko 9:00 am - Case 1 Ivo Bernat 9:15 am - Case 2 Marian Branny 9:30 am - Case 3 Ladislav Groch 9:45 am - Case 4 David Horak

121 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics Challenging Case Reviews in Modern Interventional Cardiology Sponsored by the Korean Society of Cardiology Moderators: Yang-Soo Jang, Joo-Young Yang Discussants: Taehoon Ahn, Inho Chae, Wook Sung Chung, Kyoo-Rok Han 10:00 am - Case 1: TAVR by Transaortic Approach in a Patient with Severe Aortic Stenosis and Peripheral Arterial Disease Young-Guk Ko 10:15 am - Case 2: FFR-Guided Decision Making for Anomalous Origin of RCA Bon-Kwon Koo 10:30 am - Case 3: Resuscitated Cardiac Arrest in a Patient with PCI-Related Acute Left Main Thrombosis: A PCPS Case Hyeon-Cheol Gwon 10:45 am - Case 4: Complex PCI Through the Transradial Approach Kook-Jin Chun Unexpected PCI Complications Sponsored by the Finnish Cardiac Society Moderators: Matti Jaakko Niemela, Hannu Romppanen Discussants: Pasi Karjalainen, Mikko Pietila, Antti Ylitalo 11:00 am - Case 1: Subacute Intramyocardial Hemorrhage and Tamponade After Elective PCI of a CTO Matti Jaakko Niemela 11:15 am - Case 2: Severe Clinical Instability After Elective Stenting of the LCX and LAD: What Went Wrong? Mikko Pietila 11:30 am - Case 3: Elective PCI of Triple Vessel Disease with Coronary Perforation and Emergency CABG Olli A. Kajander 11:45 am - Case 4: Late Bare Metal Stent Thrombosis in the Light of OCT: Management Options? Pasi Karjalainen 12:00 pm - Break STEMI Intervention: Canadian Perspectives Sponsored by the Canadian Association of Interventional Cardiology Moderators: Eric A. Cohen, Michael P. Love Discussants: Erick Schampaert, Jean-François Tanguay, Robert C. Welsh 2:00 pm - Case 1: Go Radial or Go Home? Sanjit S. Jolly 2:15 pm - Case 2: STEMI Cocktails Shamir R. Mehta 2:30 pm - Case 3: Drip Ship and Fix, or Drip Ship and Wait? Christopher Buller 2:45 pm - Case 4: To Stage or Not to Stage? Philippe Généreux Complex PCI: Problem Solving Sponsored by the Chinese Society of Cardiology Moderators: Run-Lin Gao, Yuejin Yang Discussants: Xianghua Fu, Yaling Han, Jian an Wang, Yujie Zhou 3:00 pm - Case 1: A Left Main Bifurcation Treated with a Two-Stent Technique Wenyi Guo 3:15 pm - Case 2: Retrograde Approach to a Complex Chronic Total Occlusion Bin Zhang 3:30 pm - Case 3: Left Main PCI in a Patient with Cardiogenic Shock Xuebo Liu 3:45 pm - Case 4: A Severely Calcified Lesion Treated with Rotational Atherectomy Yongjian Wu Unusual Solutions for Unusual Problems Sponsored by the Belgian Working Group on Interventional Cardiology Moderators: Walter Desmet, Claude Hanet Discussants: Kristoff Cornelis, Suzanne Marie Pourbaix, Paul Vermeersch 4:00 pm - Case 1: Late Complication After Rotational Atherectomy Edouard R. Benit 4:15 pm - Case 2: An Unexpected Outcome After PCI Tom Adriaenssens 4:30 pm - Case 3: When Kissing Goes Wrong Philippe Selleslagh 4:45 pm - Case 4: A Severely Stenosed Tricuspid Bioprostheses Antoine Guédès 5:00 pm - Adjourn Challenging Case Theater 2 8:00 am-5:00 pm Hall A-IMT 2 PCI Complications Usually Begin with a Simple Case Sponsored by the Croatian Cardiac Society Working Group of Interventional Cardiology Moderators: George D. Dangas, Aleksander Ernst, Maja Strozzi Discussants: Zdravko Babic, Robert Bernat, Edvard Galic, Hrvoje Pintaric 8:00 am - Case 1: Percutaneous Treatment of Catheter-Induced Dissection of the LMCA and Aortic Root Tomislav Sipic 8:15 am - Case 2: Broken Tip of a Diagnostic Right Coronary Artery Catheter Tomislav Krcmar 8:30 am - Case 3: From Simple to Nightmare Jozica Sikic 8:45 am - Case 4: Treatment of Multiple Huge SVG Aneurysms: Stent or Surgery? Kristina Maric Swiss Complication Pearls Sponsored by the Swiss Society of Cardiology Working Group on Interventional Cardiology and Acute Coronary Syndrome Moderators: Christoph A. Kaiser, Peter Wenaweser Discussants: Gabor Sutsch, Daniel Weilenmann, Stephan Windecker 9:00 am - Case 1: A Fatal Retrograde Left Main Dissection Daniel Suerder 9:15 am - Case 2: Left Ventricular Perforation by a Pigtail Catheter Stéphane Cook 9:30 am - Case 3: A Spectacularly Errant TAVR Post Dilatation Stephane Noble 9:45 am - Case 4: Disastrous Complication of a Transapical Paravalvular Mitral Leak Closure Roberto Corti Difficult Decisions During Primary PCI for STEMI Sponsored by the Polish Cardiac Society Moderators: Dariusz Dudek, Robert J. Gil Discussants: Maciej Lesiak, Andrzej J. Ochala, Adam Witkowski 10:00 am - Case 1: Patient with STEMI and Cardiogenic Shock with Acute Left Main Coronary Artery Occlusion Stanislaw Bartus 10:15 am - Case 2: Patient with STEMI and Acute Saphenous Vein Graft Occlusion Krzysztof W. Reczuch 10:30 am - Case 3: Patient with STEMI, Skull Base Fracture, and Aspirin Allergy: How to Treat? Wojciech Wojakowski 10:45 am - Case 4: Patient with STEMI, Proximal LAD Occlusion, and Complex Left Main/Multivessel Disease: How to Treat? Jacek Legutko Wednesday - October 24,

122 Wednesday, October 24 Taiwanese Complex Cardiovascular Interventions Sponsored by the Taiwan Society of Cardiovascular Intervention Moderators: Jun-Jack Cheng, Roxana Mehran Discussants: Paul Hsien-Li Kao, Wen-Lieng Lee, Chuen-Den Tseng 11:00 am - Case 1: Multiple CTOs and a Calcified Critical Lesion After Failed CABG Wen-Lieng Lee 11:15 am - Case 2: Recanalization of Bilateral Carotid Artery Occlusion Paul Hsien-Li Kao 11:30 am - Case 3: The Balloon-Cushion Stenting Technique in Left Main Primary PCI Po-Ming Ku 11:45 am - Case 4: Multiple Access Approaches for a Long Iliofemoral Occlusion Hsuan-Li Huang 12:00 pm - Break Revascularization Strategies for Complex Left Main Disease and Left Coronary Ostial Disease Sponsored by the Colegio Argentino de Cardioangiólogos Intervencionistas Moderators: Liliana R. Grinfeld, Alfredo Rodriguez, Ernesto M. Torresani Discussants: Jose A. Alvarez, Jorge Bluguermann, Mauricio G. Cohen, Anibal A. Damonte, Victor P. Moles, Jose Gomez Moreno 2:00 pm - Introduction and Objectives Ernesto M. Torresani Ostial LCX: Culotte Always 2:05 pm - Clinical Case Presentation Ruben A. Piraino 2:15 pm - Expert Case Review and Discussion Ostial LCX: Reverse T or Mini-Crush are the Strategies of Choice 2:25 pm - Clinical Case Presentation Jorge A. Baccaro 2:35 pm - Expert Case Review and Discussion Ostial LAD: Single-Stent Approach Is the Best 2:45 pm - Clinical Case Presentation Antonio Pocovi 2:55 pm - Expert Case Review and Discussion Debulking Strategies During Left Main and Bifurcations Techniques 3:05 pm - Clinical Case Presentation Jorge H. Leguizamon 3:15 pm - Expert Case Review and Discussion 3:25 pm - Discussion with Q&A 3:40 pm - Take-home Message Alfredo Rodriguez 3:45 pm - Closing Remarks Liliana R. Grinfeld PCI: The Good, the Bad, and the Ugly Sponsored by the Cardiological Society of India Moderators: Vinay K. Bahl, Ashok Seth Discussants: Amal Kumar Banerjee, Upendra Kaul, Saumitra Ray 4:00 pm - Case 1: Thankfully, the Nightmare Is Over! (My Worst Complication) Samuel K. Mathew 4:15 pm - Case 2: How Clever of Me! (My Most Innovative Solution) Sundeep Mishra 4:30 pm - Case 3: This I Will Never Forget! (My Most Educational Case) Vishal Rastogi 4:45 pm - Case 4: Case Exotica Ajit Mullasari 5:00 pm - Adjourn Maintenance of Certification (MOC) Course 8:00 am-2:00 pm Junior Ballroom C This session is only CME accredited. 8:00 am - Welcome and Introduction George D. Dangas 8:02 am - Interventional Cardiology 2012 Update Module Review Moderators: Tayo A. Addo, Emmanouil S. Brilakis Discussants: Nicola Corvaja, Kishore J. Harjai 10:00 am - Break 10:15 am - Interventional Cardiology 2011 Update Module Review Moderators: Duane S. Pinto, Kishore J. Harjai Discussants: Tayo A. Addo, Emmanouil S. Brilakis 12:00 pm - Interventional Cardiology 2010 Update Module Review Moderators: Charles E. Chambers, Nicola Corvaja Discussants: Tayo A. Addo, Emmanouil S. Brilakis 2:00 pm - Adjourn Special Sessions Japan-US Synergies in Global Medical Device Innovation: Harmonization by Doing (HBD) at TCT 8:00 am-12:30 pm Room C219 Session I. Keynote: The Japan-US Medical Device Landscape 2012 Moderators: Mitchell W. Krucoff, Shigeru Saito 8:00 am - Japan First: Speeding Device Introduction in Japan Akihiro Koide 8:20 am - Pragmatic Pre- and Post-Market Global Harmonization: Lessons from Japan and the United States Andrew Farb 8:40 am - Japan-US Synergies in the Global Marketplace: An Industry View Neal Fearnot Session II. Critical Limb Ischemia (CLI) in Japan and the United States Moderator: Kazuo Kawahara Discussants: Kenneth J. Cavanaugh Jr, William A. Gray, Akihiro Koide, Mitchell W. Krucoff, Robert Thatcher, Christopher J. White, Hiroyoshi Yokoi Neal Fearnot 9:00 am - CLI and Device Intervention in Japan Hiroyoshi Yokoi 9:10 am - CLI Definitions: Can We Speak the Same Language? Update on the Peripheral Academic Research Consortium (PARC) Christopher J. White 9:20 am - CLI and Device Intervention Across the Pacific: An FDA View Kenneth J. Cavanaugh Jr 9:30 am - Discussion 10:00 am - Break Session III. Percutaneous Valves in Japan and the United States Moderators: John Laschinger, Taka Uchida Discussants: Jodi Akin, Koji Ikeda, Fumiaki Ikeno, Michael J. Mack, Manuela Negoita, David Reuter, Stanton J. Rowe, Huay Cheem Tan, Kim Trautman 10:30 am - TAVR in Japan and the United States Jodi Akin 10:40 am - Percutaneous Mitral Valve: Where It Fits in Japan-US Today David Reuter 120

123 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics 10:50 am - Pre- and Post-Market Application of International Registries: The TVT Registry Example Michael J. Mack 11:00 am - Discussion Session IV. Japan-US Synergies in Coronary Intervention Moderators: Kazuhiro Sase, Gary Thompson Discussants: Masayuki Kawahara, Akihiro Koide, Mitchell W. Krucoff, Stephen Rowland, Shigeru Saito, Kazuaki Sekiguchi, Huay Cheem Tan, Robert Thatcher, Takahiro Uchida 11:30 am - Bioabsorbable Stent Components and Stents Shigeru Saito 11:40 am - Intervention in Calcific Coronary Arteries: A PMDA View Masayuki Kawahara 11:50 am - Biological Enhancement for Endothelial Capture Mitchell W. Krucoff 12:00 pm - Discussion 12:30 pm - Adjourn Edited Taped Case Presentations 9:30 am-5:30 pm This session is not CME/CNE accredited. Unusual Interventions Presentation Theater 1 Moderators: Massoud A. Leesar, Brij Maini, Eric E. Roselli 9:30 am - The Body Floss Technique for Treatment of a Challenging Total Femoral Artery Occlusion Thomas M Todoran 10:00 am - Superior Vena Cava Total Occlusion Sunil Pisharody 10:30 am - Radial Percutaneous Transluminal Angioplasty with Stenting of Celiac Artery and Suprarenal Abdominal Aorta in Ventilated Patient with Takayasu Arteritis and Severe Heart Failure Keyur H. Parikh 11:00 am - Break 3-D Theater Exhibit Hall 3-D Edited Taped Case Presentation 1:30 pm - 3-D Interventional Cardiovascular Procedure Silvio Bezerra Imaging and Physiology Presentation Theater 1 Moderators: Marco A. Costa, Javier Escaned, Petr Kala 2:00 pm - STEMI in Thrombotic, Vasoconstricted RCA with OCT Analysis Robert-Jan van Geuns 2:30 pm - Effect of Side Branch Stenosis on FFR of Proximal Main Vessel Stenosis Madhavpeddi Sai Aditya 3:00 pm - Break TAVR Presentation Theater 1 Moderators: Peter C. Block, Rainer Hoffmann, Augusto D. Pichard 4:00 pm - Transcatheter Aortic Valve and Valve-in-Valve Implantation in a Beating Porcine Heart: Intracardiac Endoscopic View Guido Gelpi 4:30 pm - Control of Acute Kidney Injury in TAVR by Extremely Low Contrast Multimodality Imaging Including Intracardiac Echocardiography Thomas Bartel 5:00 pm - Cutting Balloon Valvuloplasty Ramesh K. Adiraju 5:30 pm - Adjourn Challenging Case Video Presentations Session II. Coronary 10:00 am-11:00 am Hall D This session is not CME/CNE accredited. TCT A Simple Angioplasty of a Straightforward Lesion Vivek Mehan TCT Retrograde Dissection of the Aortic Sinus of Valsalva During Percutaneous Coronary Intervention Ming-yow Hung TCT Acute Myocardial Infarction in a Postpartum Patient: Is This a Coronary Dissection? Kamal Kotak TCT Campylobacter Jejuni Colitis and Cardiogenic Shock Ashish Shah TCT Combined Retrograde and Antegrade Approach with Rotablation for Treating Saphenous Vein Graft to the Obtuse Marginal and Right Coronary Artery Chronic Total Occlusions Miha Cercek TCT Stentboost Subtract Assistance in Coronary Bifurcation Angioplasty Using a Capella Stent Gerardo Nau TCT Ventricular Fibrillation Coinciding with Phentermine Initiation Patrick Tobbia TCT Extrinsic Compression of an Anomalous Left Circumflex Coronary Artery, Causing Ischemia Early After Aortic Valve Replacement: Percutaneous Treatment with Intravascular Ultrasound Guidance Guglielmo Bernardi TCT Successful Percutaneous Recanalization of a Chronic Total Coronary Occlusion Using a Retrograde Approach Through an Occluded Bypass Graft Karl Isaaz TCT Use of LASER in Treatment of Under-Expanded Stent Ashish Shah TCT Corsair Microcatheter-Induced Spiral Dissection in a Patient While Attempting PCI of a Chronic Total Occlusion Tahir Hamid TCT Rotablation in a Patient with Cardiogenic Shock and Acute ST-Elevation Myocardial Infarction Refai Showkathali TCT A Case of Successful Removal of IVUS Catheter Tip Cutoff and Trapped in Right Coronary Artery Pyung Chun Oh TCT Thrombus-Laden Right Coronary Lesion: A Novel Therapeutic Option Yean Lim TCT Retrograde Approach to a Chronic Total Occlusion in Patient on ECMO Support After Recent Myocardial Infarction Omar Hassan TCT A Complication Highlighting the Importance of IVUS Use in Left Main PCI William Wilson TCT Complicated PTCA of Left Main Total Occlusion in NSTEMI Dram Thirugnanam TCT Percutaneous Coronary Intervention (PCI) in a Lady with Immune Thrombocytopenic Purpura (ITP): Complicated by Stent Thrombosis Ashish Shah TCT A Rare Complication of Mycotic Aneurysm of Coronary After DES Implantation of LM Lesion: A Case Report Wei-chun Chang Wednesday - October 24,

124 Wednesday, October 24 TCT Retrograde Brachiocephalic Artery Recanalization with Carotid Artery Distal Protection from Dual Access (Radial and Femoral) Zoltán Ruzsa TCT Large Thrombus Burden After Primary Angioplasty Felipe Maia TCT A Sting in the Tail: Compassionate Coronary Stenting in an Elderly Patient with a Mechanical Aortic Valve and Eminent Noncardiac Surgery Tom Hyde TCT Limitations of Dissection and Reentry Techniques in the Treatment of In-Stent Restenosis Chronic Total Occlusions Shantu Bundhoo TCT Contrast Limitation by the Use of the TwinPass Microcatheter in the Treatment of Chronic Total Occlusions via the Retrograde Approach Shantu Bundhoo TCT Tale of Two Ruptured Plaques: A Case of Multivessel Acute Coronary Thrombosis Behnam Tehrani TCT Chronic Total Occlusoin Treated with Retrograde CrossBoss Sarah Johnson TCT Risks and Consequences: A Case of Very Late Stent Thrombosis Behnam Tehrani TCT Retrograde Left Main CTO PCI via OM Venous Graft Levente Molnár TCT Successful Treat LAD CTO by Transconus Branch Retrograde 300-cm Wire Externalization Technique in the Occluded Three-Vessel Patient Tien-yu Wu TCT CT-Guided Retrograde Dissection Reentry Recanalization of a Chronic Total Occlusion with a Large Proximal Cap Aneurysm in Adult Kawasaki Disease Sean Gallagher TCT Management of Left Main Stem Disease in a Patient with Previous Emergency Cardiac Surgery for Aortic Dissection Ganesh Nallur Shivu TCT A Case of Longitudinal Stent Elongation with Unique 3-D OCT Images Takehiro Yamashita TCT The Pilgrim Stent Jose Diaz Fernandez TCT Post-Stenotic Aneurysm Revealed by STEMI Nicolas Boudou TCT Functional LIMA Graft Recover After CTO PCI in LAD with Rotablator Nicolas Boudou TCT Percutaneous Recanalization of a Chronically Occluded Saphenous Vein Graft Inge Wijnbergen TCT Heavily Thrombotic Lesion During Primary PTCA: New Insight with New Device Nagendra Chouhan TCT Lost and Found: A Novel Approach to Recrossing a Coronary Dissection Eric Fuh TCT Cardiogenic Shock in Left Main and Three Vessels Coronary Artery Disease Amr Hassan TCT A Case of Myocardial Ischemia Due to Compression of the Left Main Trunk by a Large Unruptured Thoracic Aortic Aneurysm Takayuki Mitsuda TCT Successful Retrieval of a Wire Missing in the Brachial Artery by Means of a Snare Device and Guiding Catheter Li Shen TCT Retrieval of Jailed and Broken Guidewire in a Primary Angioplasty Louie Fischer TCT A Successful Stent Delivery with the 4-Fr Guide Catheter Instead of 5-Fr Guide Catheter at Mother-Child Technique Taku Iwaki TCT Need for Guideliner in Left Main Stem Percutaneous Coronary Intervention: Game Changer Nikesh Malik TCT Application of New Tips, Techniques, and Guidelines Lead to a Successful Distal Left Main Angioplasty with Two Stents Grigorios Tsigkas TCT Treatment of LM with Dedicated Bifurcation Stent in AMI Patient Indulis Kumsars TCT Trifurcation Stenting in Cardiogenic Shock: All at Once Gianluca Caiazzo TCT Ostial LMCA and Ostial RCA Stenting in a Patient with Aortoarteritis and Unusual Anatomy Sai Nvbk TCT Closing Subclavian Aneurysm in Right Aortic Arch by Covered Stent Rishi Gupta TCT Iatrogenic Stent Deformation in the Left Main Coronary Artery Elucidated by IVUS and (3-D) OCT Images Maarten Van Leeuwen TCT No-Reflow Following Carotid Artery Stenting Angelo Anzuini TCT The Successful Left Main Recanalization in a Patient with Anterior Myocardial Infarction and Cardiac Arrest Lukasz Lewicki TCT D Optical Coherence Tomography for Guidance of Complex Percutaneous Coronary Interventions Roberto Diletti TCT A Case of Stent Deformity Using Taxus Element Stent at Primary PCI for AMI Wataru Nagamatsu TCT Successful Treatment of Peristent Aneurysm Using Microcoils Secondary to Prior Percutaneous Coronary Intervention Due to Old Myocardial Infarction Sho Torii TCT Intracoronary Rendezvous Technique to Avoid Redundant Stenting Within Pseudolumen Hidetsugu Sakai TCT Transient Crush to Rescue Side-Branch Occlusion in Bifurcation Treated with the Provisional Stenting Strategy Jérôme Van Rothem TCT Management of a Heavy Calcified Lesion of the Left Main Nicolas Boudou TCT PCI to Anomalous LAD in the Presence of True LAD Prabhu Halkati TCT Thrombectomy with Novel Mother in Child Technique via Radial Approach Gabriel Maluenda 122

125 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics Presentation Theater 10:00 am-1:15 pm Please see page 170 for the Presentation Theater schedule. Morning Spotlight Sessions Deep Dive: Stroke Prevention Therapies 8:00 am-12:00 pm Room A Session I. The Noninterventional Management of Cardioembolic Stroke Moderators: Michael D. Ezekowitz, Freek W.A. Verheugt Discussant: Paul H. Kramer 8:00 am - The Heart as a Source of Stroke: Etiologies and Risk Amplifiers Paul H. Kramer 8:10 am - Anticoagulation Choices for Atrial Fibrillation: Which Drug for Which Patient? Michael D. Ezekowitz 8:25 am - Rationale for Medical Therapy to Prevent Systemic Embolization in Patients with PFO David E. Thaler 8:35 am - Indications for and Duration of Pharmacologic Therapy in Patients with Left Ventricular Aneurysm and Thrombus Freek W.A. Verheugt 8:45 am - Discussion with Q&A Session II. Interventional Approaches to Cardioembolic Stroke Moderators: William A. Gray, Vivek Y. Reddy Discussants: David W.M. Muller, Horst Sievert, Robert J. Sommer, Steven J. Yakubov 9:00 am - Surgical LAA Exclusion: Is It Effective? A. Marc Gillinov 9:10 am - Does Atrial Fibrillation Ablation Reduce Cardioembolic Stroke? Vivek Y. Reddy 9:20 am - Transcatheter LAA Occlusion: The Watchman Experience as Proof of Principle David W.M. Muller 9:35 am - Next-Generation LAA Occlusion Devices: AMPLATZER (St. Jude Medical) and WAVECREST (Coherex Medical) Horst Sievert 9:47 am - The SentreHeart Transpericardial Approach to LAA Occlusion Steven J. Yakubov 9:59 am - PFO Closure to Prevent Venous-to- Systemic Embolism: Intuitive, Yes but Where Are the Data? Robert J. Sommer 10:12 am - Discussion with Q&A Session III. Interventional Approaches to Arterial-to-Arterial Stroke Moderators: Lee R. Guterman, Jeffrey W. Olin Discussants: Tyrone J. Collins, William A. Gray 10:27 am - Atherosclerotic Carotid Bifurcation Stenosis: Primary and Secondary Prevention Strategies William A. Gray 10:39 am - Indications and Timing for Intervention in Carotid Artery Dissection Lee R. Guterman 10:51 am - Management of Fibromuscular Dysplasia of the Carotid Artery Jeffrey W. Olin 11:03 am - When Does Brachiocephalic and Vertebral Disease Warrant Intervention for Stroke Prevention, and What Are the Expected Outcomes? Tyrone J. Collins 11:15 am - Discussion with Q&A Session IV. Flash Debates in Cardioembolic Therapies Moderators: Robert S. Schwartz, Robert J. Sommer, Gregg W. Stone Discussants: Eric R. Bates, Michael D. Ezekowitz, James D. Joye, Brian K. Whisenant Improvements in Anticoagulation Therapy Obviate the Need for LAA Occlusion Therapies 11:30 am - Pro! Michael D. Ezekowitz 11:35 am - Con! Brian K. Whisenant 11:40 am - Discussion and Vote Is Renal Artery Denervation a Stroke Prevention Therapy? 11:45 am - Pro! James D. Joye 11:50 am - Con! Eric R. Bates 11:55 am - Discussion and Vote 12:00 pm - Adjourn From Clinical Trial Evidence to Clinical Practice: Unraveling the Issues 8:00 am-11:30 am Room A :00 am - Welcome and Introduction Roxana Mehran 8:03 am - Keynote Address: Translating Clinical Evidence into Clinical Practice: A Critical Appraisal (with Case Examples) Sanjay Kaul Session I. Acute MI Therapies Moderators: Roxana Mehran, Stuart J. Pocock Discussants: Christopher B. Granger, Henning Kelbaek, Helen Parise, Matthew T. Roe, Philippe Gabriel Steg 8:23 am - Lessons from the HORIZONS-AMI and INFUSE-AMI Trials Helen Parise 8:38 am - A View to Future Trials: HORIZONS-AMI II and Others Roxana Mehran 8:48 am - Discussion with Q&A Session II. Value of Functional Ischemia in Clinical Practice Moderators: Roxana Mehran, Stuart J. Pocock Discussants: Christopher B. Granger, David J. Maron, Bonnie H. Weiner, Stephen G. Worthley 9:03 am - Lessons from FAME II Stuart J. Pocock 9:15 am - Design and Rationale of ISCHEMIA David J. Maron 9:27 am - Discussion with Q&A Session III. Valvular Heart Disease: Focus on Patient Selection/Composite Endpoints Moderators: David J. Cohen, Stuart J. Pocock Discussants: Somjot S. Brar, Ted E. Feldman, Karl-Heinz Kuck, Michael J. Mack, Jeffrey J. Popma 9:42 am - Lessons from EVEREST II Ted E. Feldman 9:57 am - Design and Rationale of COAPT Michael J. Mack 10:07 am - Lessons from the PARTNER Trials Stuart J. Pocock 10:22 am - Design and Rationale of the CoreValve Trials Jeffrey J. Popma 10:32 am - Discussion with Q&A Wednesday - October 24,

126 Wednesday, October Session IV. Debate: Observational Registries vs. RCTs Moderators: Kevin J. Beatt, Stuart J. Pocock Discussants: Somjot S. Brar, Charles J. Davidson, Sheldon Goldberg, Robert A. Harrington, William S. Weintraub 10:52 am - Registries Get at Reality: ASCERT and Others! William S. Weintraub 11:04 am - If You Want the Truth, Randomize! Robert A. Harrington 11:16 am - Discussion with Q&A 11:30 am - Adjourn Innovative Surgical Techniques and Technologies Co-sponsored by the American Association for Thoracic Surgery 8:00 am-12:05 pm Junior Ballroom D This session is only CME accredited. Session I. Coronary Artery Disease Moderators: A. Marc Gillinov, Neil E. Moat Discussants: Stephanie Lynn Mick, Craig R. Smith, David X. Zhao 8:00 am - Is Off-Pump Ever the Right Choice? Craig R. Smith 8:10 am - Intraoperative Graft Assessment: Flow Analysis vs. Angiogram? David X. Zhao 8:20 am - All Arterial Revascularization: Is It Really Worth the Effort? Stephanie Lynn Mick 8:30 am - Discussion with Q&A Session II. Valvular Heart Disease Moderators: Neil E. Moat, Vinod H. Thourani Discussants: Isaac George, A. Marc Gillinov, Wilson Y. Szeto 8:40 am - Transcatheter Mitral Technology on the Horizon Francesco Maisano 8:50 am - Surgery After Failed MitraClip Procedures: How Often Is Repair Feasible? Michael J. Davidson 9:00 am - Sutureless Surgical Aortic Valve Replacement: Is There a Role in the TAVR Era? Vinod H. Thourani 9:10 am - Transapical Closure of Paravalvular Leaks Isaac George 9:20 am - LV Apical Closure Devices Wilson Y. Szeto 9:30 am - Robotic Mitral Repair: Gimmick or Major Advance? A. Marc Gillinov 9:40 am - Discussion with Q&A Session III. Atrial Fibrillation Moderator: Husam H. Balkhy Discussants: William E. Cohn, A. Marc Gillinov, Randall J. Lee 9:55 am - Lone Surgical Treatment of Atrial Fibrillation: Meaningful Progress in the Past 15 Years? William E. Cohn 10:05 am - Hybrid Surgical and Percutaneous AF Ablation Husam H. Balkhy 10:15 am - Concomitant Surgical Ablation: What Is the Right Procedure? A. Marc Gillinov 10:25 am - Closure of the Left Atrial Appendage: Surgical Approaches and Results A. Marc Gillinov 10:33 am - Closure of the Left Atrial Appendage: Transcatheter Approaches and Results Randall J. Lee 10:41 am - Discussion with Q&A Session IV. Heart Failure Moderators: William E. Cohn, Stephanie Lynn Mick Discussants: Robert E. Michler, Amit Patel 10:51 am - The Future of Surgical VADs William E. Cohn 11:05 am - Is SVR for CHF DOA? Robert E. Michler 11:15 am - Stem Cell Therapy: The Hype and the Hope Amit Patel 11:25 am - Discussion with Q&A Session V. Surgical Innovations Moderators: Emile Bacha, William E. Cohn Discussants: Husam H. Balkhy, Michael J. Davidson, Isaac George, A. Marc Gillinov, A. Pieter Kappetein, Wilson Y. Szeto, Vinod H. Thourani 11:35 pm - Past Successes and Future Needs: A Roundtable Discussion 12:05 pm - Adjourn Next-Generation Transcatheter Mitral Valve Therapies 8:00 am-12:06 pm Room A This session is only CME accredited. Session I. Past Revisited and Future Predicted Moderators: Maurice Buchbinder, Horst Sievert Discussants: David H. Adams, Jan Harnek, Howard C. Herrmann, Samir R. Kapadia, D. Craig Miller, Nicolas M. van Mieghem 8:00 am - A Retrospective Analysis of a Decade of (Mostly) Failed Device Approaches for Mitral Regurgitation (MR): Why Has Progress Been So Agonizingly Slow? Samir R. Kapadia Instructive Debate: Will Transcatheter Therapies Ever Match the Surgical Standard for MR? 8:10 am - No: In This Case Even the Most Ingenious Percutaneous Approaches Are Doomed to Fall Short! Patrick M. McCarthy 8:18 am - Yes: Like PCI and CABG, It s Only a Matter of Time (and Money)! Jan Harnek 8:26 am - Discussion with Q&A Session II. Coronary Sinus Mitral Annuloplasty Moderators: Ted E. Feldman, Samir R. Kapadia Discussants: Steven L. Goldberg, Jan Harnek, Robert J. Lederman, Robert J. Lederman, Ahmed Magdy, Wesley R. Pedersen, Joachim Schofer 8:36 am - The Carillon: Device Iteration, New Data, New Trials Steven L. Goldberg 8:46 am - Two Instructive Carillon Cases: One That Worked and One That Didn t Joachim Schofer 8:58 am - Mitral Valve Cerclage: Concept and Practicality Robert J. Lederman 9:06 am - Discussion with Q&A Session III. Direct Mitral Annuloplasty Moderators: Eberhard Grube, Karl-Heinz Kuck Discussants: Lutz Buellesfeld, Robert A. Guyton, Richard R. Heuser, Franz X. Kleber, Francesco Maisano, Konstantinos Spargias, Zoltan G. Turi 9:16 am - Challenges for Percutaneous Suture and Band Annuloplasty: Surgical Perspectives Robert A. Guyton 9:26 am - Mitralign Bident Program Update Lutz Buellesfeld 9:36 am - Accucinch (Guided Delivery Systems) Program Update Franz X. Kleber 9:46 am - Cardioband (Valtech Cardio) Program Update Francesco Maisano 9:56 am - Perspectives on Direct Annuloplasty: Who Are the Right and Wrong Patients (with Case Examples)? Eberhard Grube 10:04 am - Discussion with Q&A

127 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics Session IV. Transcatheter Mitral Valve Replacement Moderators: Francesco Maisano, Jason H. Rogers Discussants: Shmuel Banai, Jose A. Condado, Michael J. Davidson, Adrian Ebner, George Lutter, Nicolo Piazza, Lars Sondergaard 10:16 am - Position Statement from a Surgeon: Transcatheter MV Replacement Is a Step Backward and Unlikely to Work! Michael J. Davidson 10:26 am - Featured Lecture: CardiAQ Program Update: Featuring the World s First Successful Transcatheter Mitral Valve Implant Lars Sondergaard 10:38 am - Tiara (Neovasc) Program Update Shmuel Banai 10:46 am - Lutter Valve Update George Lutter 10:56 am - Discussion with Q&A Session V. Other Transcatheter Mitral Approaches Moderators: Scott Lim, Michael J. Mack Discussants: Richard C. Daly, D. Craig Miller, Alfredo Trento, Nicolas M. van Mieghem, Francis C. Wells, Jian Ye 11:08 am - First Report: St. Jude Medical Percutaneous Mitral Repair Device: Device Description, Preclinical, and First-in-Human Results Francis C. Wells 11:20 am - CardioSolutions MitraSpacer: Temporary Use and Permanent Implant Jian Ye 11:30 am - Do Adjustable Mitral Annuloplasty Rings Address an Unmet Clinical Need? Patrick M. McCarthy 11:38 am - Micardia Update: Surgical and Percutaneous Device Progress Maurice Buchbinder 11:46 am - Neocord Update: From Surgical TACT Trial Update to Percutaneous Chords Richard C. Daly 11:54 pm - Discussion with Q&A 12:06 pm - Adjourn The Use and Abuse of Appropriate Use Criteria (AUC): A Case-Based Tutorial 8:00 am-12:00 pm Room A Session I. Current Options for Ensuring PCI Quality Performance Moderators: Ajay J. Kirtane, Manesh R. Patel Discussants: Joseph D. Babb, Kurt Huber, Spencer B. King III, J. Jeffrey Marshall, Steven P. Marso 8:00 am - AUC: We Must Be Knights, Not Knaves, for the Profession Spencer B. King III 8:15 am - Good Intentions Gone Bad: Problems with AUC Steven P. Marso 8:30 am - The Hippocratic Oath as a Guide Rather Than the AUC J. Jeffrey Marshall 8:40 am - ESC Guidelines: No Need for AUC for PCI: A European Perspective Kurt Huber 8:50 am - Discussion with Q&A Session II. Case-Based Debates on the AUC (for Diagnostic Catheterization and Revascularization) Moderators: J. Jeffrey Marshall, Steven P. Marso Discussants: Joseph D. Babb, Sorin J. Brener, Larry S. Dean, Kurt Huber, Ajay J. Kirtane, Manesh R. Patel, Samin K. Sharma 9:10 am - Case Presentation 1: How to Use the AUC as Part of Routine Morbidity and Mortality Conference Review Samin K. Sharma 9:25 am - Discussion with Q&A 9:30 am - Case Presentation 2: Example of Abuse of AUC Ajay J. Kirtane 9:45 am - Discussion with Q&A 9:50 am - Case Presentation 3: Uncovered AUC Scenarios: How Should These Types of Cases Be Handled? Srihari S. Naidu 10:05 am - Discussion with Q&A 10:10 am - Case Presentation 4: AUC and the Elephant in the Room: Unnecessary Stents Larry S. Dean 10:25 am - Discussion with Q&A Session III. AUC Moving Forward: Obstacles and Goals Moderator: Manesh R. Patel Discussants: Steven R. Bailey, Hitinder S. Gurm, Christopher J. White 10:30 am - Tools for Everyday Use of AUC Steven R. Bailey 10:45 am - Peer Review and Incorporation of AUC Christopher J. White 11:00 am - AUC and State PCI Registries: The Michigan State PCI Registry Example Hitinder S. Gurm 11:15 am - Face the Facts, AUC Are Here to Stay: 2012 Update on the Current Use and Future Directions of AUC Manesh R. Patel 11:30 am - Discussion with Q&A 12:00 pm - Adjourn Lunchtime Activities Hot Topics ACC Special Fellows Session I. Valvular Heart Disease: Year in Review :15 pm-1:48 pm Room C This session is only CME accredited. Moderators: Josep Rodes-Cabau, E. Murat Tuzcu 12:15 pm - Percutaneous Mitral Valve Repair: Insights on Patient Selection and Results in Degenerative and Functional Mitral Regurgitation Ted E. Feldman 12:27 pm - Discussion with Q&A 12:30 pm - Evaluation and Treatment of Right-Sided Valve Disease (Pulmonary and Tricuspid) Michael J. Landzberg 12:42 pm - Discussion with Q&A 12:45 pm - Low Gradient Aortic Stenosis in Patients with Low and Preserved Left Ventricular Ejection Fraction: From Evaluation to Treatment Philippe Pibarot 12:57 pm - Discussion with Q&A 1:00 pm - Role of Multimodality Imaging in the Evaluation of Aortic Valve Disease Maurice E. Sarano 1:12 pm - Discussion with Q&A 1:15 pm - Patient Selection for TAVR: Which Patients Should and Should Not Undergo a TAVR Procedure? Samir R. Kapadia 1:27 pm - Discussion with Q&A 1:30 pm - TAVR in 2012: Clinical Evidence and Unresolved Issues Raj Makkar 1:45 pm - Discussion with Q&A 1:48 pm - Adjourn Difficult Patients in Interventional Cardiology 12:15 pm-1:50 pm Room C Moderators: Alexandra J. Lansky, John A. McPherson, Manish A. Parikh Discussants: Herbert D. Aronow, Michael J. Rinaldi, Fayaz Shawl 12:15 pm - Approach to the Patient with Renal Failure and Multivessel CAD Harry R. Phillips Wednesday - October 24, 2012

128 Wednesday, October 24 12:30 pm - Discussion with Q&A 12:35 pm - Management of Diffuse Restenosis After DES Alaide Chieffo 12:45 pm - Discussion with Q&A 12:50 pm - Strategies for the ACS Patient with Chronic Atrial Fibrillation C. Michael Gibson 1:00 pm - Discussion with Q&A 1:05 pm - Revascularization in the Patient with Severe Aortic Stenosis James B. Hermiller Jr 1:15 pm - Discussion with Q&A 1:20 pm - Approach to Threatened, Imminent, and Actual Cardiac Arrest in the Cath Lab John M. Lasala 1:30 pm - Discussion with Q&A 1:35 pm - Options for Patients with ACS and No Palpable Pulses Alexander Grigorievich Osiev 1:45 pm - Discussion with Q&A 1:50 pm - Adjourn Dual Antiplatelet Therapy Controversies 12:15 pm-1:45 pm Room D Controversy I. Debate: Which ADP Antagonist in ACS? Moderators: A. Michael Lincoff, Freek W.A. Verheugt Discussants: Dimitrios Alexopoulos, Joost Daemen, Walter Desmet, David Erlinge, Lisa K. Jennings, Shamir R. Mehta, Michelle O Donoghue, Matthew J. Price 12:15 pm - Prasugrel Is the Gold Standard! Matthew J. Price 12:25 pm - Ticagrelor Is the Right Choice: More Potent, Better Data! Dimitrios Alexopoulos 12:35 pm - Clopidogrel Is Still the Choice for Most! Shamir R. Mehta 12:45 pm - A Representative Case with a Complication: Stent Thrombosis or Major Bleed? David Erlinge 12:55 pm - Discussion with Q&A Controversy II. Debate: Duration of DAPT Post DES Moderators: Dean J. Kereiakes, Marco Valgimigli Discussants: Joost Daemen, Germano Di Sciascio, Myeong-Ki Hong, Laura Mauri, Wojciech Wojakowski 1:05 pm - Longer Is Better Is Old School Thinking! Marco Valgimigli 1:15 pm - The Longer the Better Is Still the Way to Go, at Least for Now! Laura Mauri 1:25 pm - A Representative Case with a Complication: Stent Thrombosis or Major Bleed? Wojciech Wojakowski 1:35 pm - Discussion with Q&A 1:45 pm - Adjourn Guideline Directions and Controversies (Part 1): STEMI and NSTEMI 12:15 pm-1:45 pm Room C Moderators: Neal S. Kleiman, Frederick Kushner 12:15 pm - Should All Patients with STEMI Be Transferred to a PCI-Capable Hospital? Jacqueline E. Tamis-Holland 12:25 pm - Discussion with Q&A 12:30 pm - Medical Therapy During Interhospital Transport: Fibrinolytic and/or Anticoagulant? Frans Van de Werf 12:40 pm - Discussion with Q&A 12:45 pm - Should Aspiration Thrombectomy Be First-line Therapy? Sameer Mehta 12:55 pm - Discussion with Q&A 1:00 pm - PCI of the Non-Infarct Vessel: Go or No-Go? John A. Bittl 1:10 pm - Discussion with Q&A 1:15 pm - Should P2Y12 Antagonists Be Continued Through CABG in Patients with ACS? Adnan Kastrati 1:25 pm - Discussion with Q&A 1:30 pm - Systemic Hypothermia: For Hospital Arrest and Myocardial Infarction? Goran K. Olivecrona 1:40 pm - Discussion with Q&A 1:45 pm - Adjourn Novel Findings from Randomized and Nonrandomized Studies 12:15 pm-1:45 pm Room D This session is only CME accredited. Moderators: James H. Chesebro, Michael J. Cowley Discussants: Donald Cutlip, Hitinder S. Gurm, Luis A. Guzman, Michalis Hamilos, Eric Horlick, Norman E. Lepor 12:15 pm - PARTNER: Early and Late Outcomes of Transcatheter Valve-in-Valves for Failed Balloon Expandable Transcatheter Aortic Valves Raj Makkar 12:25 pm - Discussion 12:30 pm - PARTNER: Prognostic Value of Low Flow in Patients with Severe Aortic Stenosis Howard C. Herrmann 12:40 pm - Discussion 12:45 pm - ADAPT-DES IVUS Substudy: Utility of IVUS in Delineating the Mechanism of and Preventing Stent Thrombosis Akiko Maehara 12:55 pm - Discussion 1:00 pm - Stent Thrombosis Results from a Registry in 18,334 Patients Tomohisa Tada 1:10 pm - Discussion 1:15 pm - DESERT: Final Analysis of the Clinical and Angiographic Predictors of Stent Thrombosis from a Large, Multicenter Registry Ron Waksman 1:25 pm - Discussion 1:30 pm - ATLAS ACS-2 TIMI 51: Stent Thrombosis in Patients with Acute Coronary Syndromes Treated with Rivaroxaban C. Michael Gibson 1:40 pm - Discussion 1:45 pm - Adjourn So You Think You Have a Great Idea? An Inventor s Workshop Sponsored by Stanford Biodesign 12:15 pm-1:45 pm Room C This session is only CME accredited. Moderator: Paul G. Yock Discussants: Maurice Buchbinder, Thomas J. Fogarty, Julio C. Palmaz, Richard S. Stack 12:15 pm - Introduction and Goals Paul G. Yock 12:18 pm - Secret Sauce: The Right Clinical Need Todd J. Brinton 12:26 pm - Assessing the Market (Without Hiring an MBA) Jay Watkins 12:34 pm - IP 101: Is Your Device Patentable? James R. Shay 12:42 pm - Mapping out FDA and CE Strategy Aaron V. Kaplan 12:50 pm - Getting Real: Practical Next Steps Peter J. Fitzgerald 126

129 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics 12:58 pm - Q&A with the Master Inventors 1:45 pm - Adjourn Special Circulation Journal Session: The Most Important Papers from the Last Year 12:15 pm-1:45 pm Room D This session is only CME accredited. 12:15 pm - Introduction David P. Faxon Rethinking the Duration of Dual Antiplatelet Therapy Moderator: Theodore A. Bass Discussants: J. Dawn Abbott, Dominick J. Angiolillo, Hyeon-Cheol Gwon, Mitchell W. Krucoff, Marco Valgimigli 12:16 pm - Six-Month vs. 12-Month Dual Antiplatelet Therapy After Implantation of Drug-Eluting Stents: The Efficacy of Xience/ Promus vs. Cypher to Reduce Late Loss After Stenting (EXCELLENT) Randomized, Multicenter Study. Circulation. 2012;125: Hyeon-Cheol Gwon 12:23 pm - Short- vs. Long-term Duration of Dual Antiplatelet Therapy After Coronary Stenting: A Randomized Multicentre Trial. Circulation. 2012;125: Marco Valgimigli 12:30 pm - Discussion with Q&A Expanding Indications for TAVR Moderator: David O. Williams Discussants: Peter Boekstegers, Antonio Colombo, Michael J. Davidson, Sachin S. Goel 12:46 pm - Percutaneous Coronary Intervention in Patients with Severe Aortic Stenosis: Implications for Transcatheter Aortic Valve Replacement. Circulation. 2012;125: Sachin S. Goel 12:55 pm - Transcatheter Aortic Valve Implantation in Patients With Severe Left Ventricular Dysfunction: Immediate and Mid-term Results: A Multicenter Study. Circ Cardiovasc Interv. 2012;5: Antonio Colombo 1:02 pm - Discussion with Q&A Who Needs Complete Revascularization? Moderator: David P. Faxon Discussants: Sripal Bangalore, Donald Cutlip, Jane A. Leopold, Gregg Rosner, Gary L. Schaer, Stephan Windecker 1:15 pm - Impact of Completeness of Revascularization on Long-term Cardiovascular Outcomes in Patients with Type 2 Diabetes Mellitus: Results from the Bypass Angioplasty Revascularization Investigation 2 Diabetes (BARI 2D). Circ Cardiovasc Interv. 2012;5: Sripal Bangalore 1:22 pm - Impact of the Presence and Extent of Incomplete Angiographic Revascularization After Percutaneous Coronary Intervention in Acute Coronary Syndromes: The ACUITY Trial. Circulation. 2012;125: Gregg Rosner 1:29 pm - Discussion with Q&A 1:44 pm - Concluding Remarks David O. Williams 1:45 pm - Adjourn Tough Calls in the Cath Lab: What Is This, and What Do We Do Now? 12:15 pm-1:45 pm Room D This session is only CME accredited. Case Presentations Moderators: Carlo Di Mario, Zoltan G. Turi 12:15 pm - Tough Call During a TAVR Raj Makkar 12:35 pm - Tough Call Using MitraClip Ted E. Feldman 12:55 pm - Tough Call During Cardiac Support Navin K. Kapur 1:05 pm - Tough Call During a LAA Occlusion Vivek Y. Reddy 1:25 pm - Tough Call During a HOCM Ablation Carey D. Kimmelstiel 1:45 pm - Adjourn Learn the Technique These sessions are only CME accredited. Acute Stroke Intervention 12:15 pm-1:45 pm Room A209 Moderators: L. Nelson Hopkins, Philip M. Meyers Discussants: Mohammad Ali Aziz-Sultan, Italo Linfante, Stephen R. Ramee Case I 12:15 pm - Anatomy for Stroke Intervention Philip M. Meyers 12:21 pm - Concentric Merci Case Philip M. Meyers Case II 12:30 pm - Patient Selection: Clinical Imaging Italo Linfante 12:36 pm - Penumbra Case Italo Linfante Case III 12:45 pm - Successful Stent-Retriever Case: Current Technical Options for Successful Revascularization Mohammad Ali Aziz-Sultan 12:51 pm - Stent-Retriever Case Mohammad Ali Aziz-Sultan Case IV 1:00 pm - Complication Avoidance and Management L. Nelson Hopkins 1:06 pm - Hemorrhage Post Revascularization L. Nelson Hopkins Case V 1:15 pm - How to Train Non- Neurointerventionalists to Treat Acute Ischemic Stroke Stephen R. Ramee 1:21 pm - Perforation and Management Stephen R. Ramee 1:30 pm - Discussion with Q&A 1:45 pm - Adjourn Complex Congenital Intervention 12:15 pm-1:45 pm Room B211 Moderators: Ziyad M. Hijazi, John F. Rhodes Discussants: Elchanan Bruckheimer, Huseyin Ince, Doff B. McElhinney, Horst Sievert, Robert J. Sommer 12:15 pm - Coarctation of the Aorta: Techniques for Stent Implantation Elchanan Bruckheimer 12:25 pm - Two Illustrative Cases of Coarctation Stent Placement: One Uncomplicated, One Complex Horst Sievert 12:40 pm - Discussion with Q&A 12:45 pm - Coronary AV Fistulas: Treatment Techniques John F. Rhodes 12:55 pm - Two Illustrative Cases of Fistula Occlusion: One Uncomplicated, One Complex Christoph A. Nienaber 1:10 pm - Discussion with Q&A 1:15 pm - Percutaneous Pulmonary Valve Replacement: Indications and Technique Doff B. McElhinney 1:25 pm - Two Illustrative Cases: One Melody, One Edwards Robert J. Sommer 1:40 pm - Discussion with Q&A 1:45 pm - Adjourn CTO Antegrade Reentry Techniques 12:15 pm-1:45 pm Room B210 Moderators: Stéphane Rinfret, R. Michael Wyman Discussants: Tony J. DeMartini, Ashish Pershad, James Spratt Wednesday - October 24, 2012

130 Wednesday, October 24 12:15 pm - History and Evolution of Antegrade Dissection Reentry Techniques for Coronary Chronic Total Occlusion PCI J. Aaron Grantham 12:28 pm - Utilization of Intravascular Ultrasound for Intralesional Rewiring in CTO: A Step-by-Step Approach Satoru Sumitsuji 12:41 pm - The Stingray Reentry Technology Ashish Pershad 12:54 pm - How to Manage the Dissection Space: Knuckle Wires, CrossBoss, Catheter Exchanges, and More Stéphane Rinfret 1:07 pm - Troubleshooting Loss of Visualization During Dissection Reentry James Spratt 1:20 pm - Putting It All Together: Tips and Tricks to Optimize Technical Success Using Dissection Reentry in the Antegrade Direction R. Michael Wyman 1:32 pm - Discussion with Q&A 1:45 pm - Adjourn Interventional Rich Emotional Experiences 12:15 pm-1:45 pm Room B214 Moderators: Sorin J. Brener, David R. Holmes Jr, Jeffrey J. Popma Coronary Perforations 12:15 pm - Case Presentation: Massive Coronary Perforation Jeffrey J. Popma 12:22 pm - Why It Happens and How to Prevent It Jeffrey J. Popma Slow and No Reflow After PCI 12:35 pm - Case Presentation: No Reflow Sorin J. Brener 12:42 pm - Predictors and Therapies for Abrupt Vessel Closure and No Reflow Sorin J. Brener Left Main Bifurcation Stenting with Complications 12:55 pm - Case Presentation: Distal Left Main Stenting with Complications Kenneth Chin 1:02 pm - One or Two Stents and How to Avoid Complications Kenneth Chin vascular Access Complications 1:15 pm - Case Presentation: A Terrible Vascular Complication David R. Holmes Jr 1:22 pm - How to Screen for Femoral TAVR Compatibility Plus Avoid and Treat Access Site Complications David R. Holmes Jr 1:35 pm - Discussion with Q&A 1:45 pm - Adjourn Nuts and Bolts of IVUS 12:15 pm-1:45 pm Room B212 Moderators: John McB. Hodgson, Clemens von Birgelen Discussants: Stéphane Cook, Danny Dvir, Rainer Hoffmann, Erick Schampaert, Jose M. de la Torre Hernandez 12:15 pm - Fundamentals of IVUS Acquisition and Analysis John McB. Hodgson 12:23 pm - Case 1: Standard IVUS Guided Pre- and Post-Stent Implantation John McB. Hodgson 12:33 pm - Case 2: IVUS Guided Diagnosis and Therapy of In-Stent Restenosis Ricardo A. Costa 12:43 pm - Case 3: IVUS Guided Stenting in Calcified Disease Rainer Hoffmann 12:53 pm - Case 4: IVUS for Intermediate Left Main Lesions Jose M. de la Torre Hernandez 1:03 pm - Using IVUS for Assessment and Treatment Guidance of PCI Complications Clemens von Birgelen 1:11 pm - Case 5: Malapposition or Strut Deformation Resulting in Thrombosis Danny Dvir 1:21 pm - Case 6: Geographic Miss (or The Ultimate Miss: Lost Stent) Akiko Maehara 1:31 pm - VH-IVUS: Cath Lab Basics Clemens von Birgelen 1:39 pm - Case 7: Potential Clinical Use of VH-IVUS in the Cath Lab Akiko Maehara 1:45 pm - Adjourn Transseptal Puncture 12:15 pm-1:45 pm Room A208 Moderators: William A. Gray, Morton J. Kern Discussants: Saibal Kar, Igor F. Palacios, Ramon Quesada, Brian K. Whisenant Session I. Didactic Overview 12:15 pm - Anatomy of the Interatrial Septum for the Interventionalist Carlos E. Ruiz 12:25 pm - Discussion with Q&A 12:30 pm - Transseptal Puncture: Step-by- Step With and Without Echo Guidance William A. Gray 12:40 pm - Discussion with Q&A Session II. Transseptal Cases 12:45 pm - Case 1: Complication of Transseptal Puncture Igor F. Palacios 12:57 pm - Case 2: Optimal Transseptal Puncture for the MitraClip Saibal Kar 1:09 pm - Case 3: Optimal Transseptal Puncture for LAA Occlusion Brian K. Whisenant 1:21 pm - Case 4: Transseptal Puncture for Hemodynamic Assessment Morton J. Kern 1:33 pm - Case 5: Transseptal Puncture for Paravalvular Leak Closure Ramon Quesada 1:45 pm - Adjourn Venous Disease Intervention 12:15 pm-1:45 pm Room B213 Session I. Deep Venous Disease Moderators: Raghu Kolluri, Mahmood K. Razavi 12:15 pm - The Deep Vein Thrombosis Problem: How Strong Is the CAVENT Study Evidence? Anthony J. Comerota 12:22 pm - Is There Any Benefit in Recanalizing Chronic Central Venous Occlusions? Mahmood K. Razavi 12:29 pm - Catheter Intervention in Pulmonary Embolism: When and How Nilesh Goswami 12:36 pm - Case 1: A Patient with Bilateral Deep Vein Thrombosis Anthony J. Comerota 12:43 pm - Case 2: Management of Clotted Inferior Vena Cava Filter Mahmood K. Razavi 12:50 pm - Case 3: Single Session Treatment of Iliofemoral Deep Vein Thrombosis Greg Mishkel Session II. Superficial Venous System Moderators: Raghu Kolluri, Mahmood K. Razavi 12:57 pm - Update in the Management of Superficial Venous Disease Lowell Kabnick 128

131 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics Debate: In Patients with Chronic Venous Insufficiency, Must the Obstructive Lesions in the Deep Venous System Be Stented Before Treating the Superficial System? 1:07 pm - Pro! Mahmood K. Razavi 1:14 pm - Con! Raghu Kolluri 1:21 pm - Case 4: Ambulatory Phlebectomy (Office-Based) Raghu Kolluri 1:28 pm - Case 5: Perforator Ablation Step by Step Lowell Kabnick 1:35 pm - Update on Interventions for Dialysis Fistulas John A. Bittl 1:45 pm - Adjourn Challenging Case Video Presentations Session III. Coronary 2:00 pm-3:00 pm Hall D This session is not CME/CNE accredited. TCT Acute Myocardial Infarction and Thrombus in Ascendant Aorta: Approach, Diagnosis, and Outcome: The Treatment of a Nonstenotic Cause of Acute Myocardial Infarction Felix Damas De Los Santos TCT Rotational Ablation for a Protruding Stent from the Ramus Branch Which Compromised the Ostium of LCX Max Woo TCT Left Main Stem Thrombotic Closure as a Presentation of Acute Myocardial Infarction Complicated by Cardiogenic Shock Marco Wainstein TCT Pot and Tap in Left Main Stenting Where Two Stents Were Used Sivakumar Rathinavel TCT Successful Treatment of Prolonged Out-of-Hospital Cardiac Arrest with Automatic Mechanical Chest Compression Enabling Performance of Primary PCI Petr Hajek TCT PCI in Left Circumflex Artery with Important Angulation Nicolas Boudou TCT Complex Coronary Intervention Using Percutaneous Left Ventricular Assist Device Harit Desai TCT Hidden Micro-Channel Tracking by Reverse Wire Technique in Percutaneous Coronary Intervention for Semioccluded Lesion Keita Okayama TCT A Retrieval of Polytetrafluoroethylene-Covered Stent After Unsuccessful Delivery to Coronary Perforation Kentaro Meguro TCT Successful Two Steps Antegrade Recanalization of a Complex Chronic Total Coronary Occlusion With 5-Fr Guiding Catheter For Guidewire Crossing at Second Attempt and Switch to a 7-Fr Guiding Catheter Using an Antegrade Guidewire Anchoring Technique Karl Isaaz TCT PCI of Giant Aneurysm Lesions on STEMI by Radial Approach Mauricio Vanegas TCT Intravascular Ultrasound Guided Antegrade Wiring of Stumpless Chronic Total Coronary Occlusion Patrick Siegrist TCT Collapse of the Stent in RCA: Challenges Faced Ganesh Kumar TCT From STEMI to Pulmonary Embolism: Intrapulmonary Fibrinolysis Application During Cardiopulmonary Resuscitation Dejan Jovic TCT TAVI Is Not the End of the Story: A Case Report of Percutaneous Coronary Intervention After Transcatheter Aortic Valve Implantation Slim Mehdi TCT An Unusual Case of Coronary Artery Dissection: Semicompliant Balloon Rupture at Low Pressure Resulting in Barotrauma and Distant Proximal Extensive Dissection of an Uninvolved Bifurcation Rupert Williams TCT Coronary Artery Rupture During Left Main Intervention in a Patient with Severe Aortic Stenosis Niket Patel TCT Treatment of Late Incomplete Stent Apposition after Subintimal Sirolimus and Everolimus Eluting Stent Implantation Shimpei Nakatani TCT A Successful Team Treatment for Left Main Shock Syndrome Cheng Yutong TCT Retrograde CTO via RV Marginal John Forrest TCT Bypass Graft Angiogram Guided Left Main and Right Coronary Artery Total Occlusion Percutaneous Coronary Intervention in Single Sitting Vijayakumar Subban TCT Anchor Technique for Stent Deployment Yusuf Kumble TCT Visualization of Kissing Balloon Dilation Induced Stent Deformation by Optical Coherence Tomography Antonios Karanasos TCT Stent Slippage or Breakage Balijepalli Sudhakar TCT Iatrogenic Migration of Carotid Stent Sandeep Basavarajaiah TCT Left Main Stenting in a Nine-Year- Old Child with Hypercholesteroleamia Nireen Okasha TCT The LIMA Is Not Enough: PCI to Left Main Stem CTO to Improve Flow in the Circumflex Benjamin Wrigley TCT Retrograde CTO PCI Complicated by Wire Knot Formation Involving Antegrade and Retrograde Wires William Wilson TCT Antegrade Approach for Three Vessel CTO Lesions Euihong Ko TCT How Do I Treat RCA Perforation When Only Transradial 5-Fr Sheath Available? Hsiu-yu Fang TCT Rotational Atherectomy for Stent Ablation of Severe Recent Underexpanded Stent Implantation Roberto Garbo TCT Primary Angioplasty: How Extreme Can It Be? Sandeep Basavarajaiah TCT Coronary Vasospasm Associated with Thyrotoxicosis Wook Bum Pyun TCT Successful Removal of Entrapped Intravascular Ultrasound Catheter Due to Longitudinal Deformation of Recent Generation Drug-Eluting Stent Yoshiyuki Suzuki TCT Anchoring Balloon to Assist Access to a Jailed LAD During Primary PCI Enrique Gutierrez Ibañes TCT When One Stent Is Not Enough: Using a Dedicated Stent for Bifurcation Disease Peter O kane Wednesday - October 24, 2012

132 Wednesday, October 24 TCT Longitudinal Deformation of Promus Element Stent by Passive Deep Engagement of Guiding Catheter During Retrograde Recanalization of Chronic Total Occlusion Jung-kyu Han TCT More Than Just Muscle Bridging Sunita Avinash TCT Longitudinal Stent Deformation in Complex Left Main Bifurcation Stenting with TRYTON and PROMUS ELEMENT Stents Jose Diaz Fernandez TCT Rotational Atherectomy and Stent Implantation on Right Coronary Artery in a Patient with a History of Previous Ineffective Attempts of PCI on the Same Artery Cinzia Moncalvo TCT Management of Life Threatening Left Anterior Descending Artery Perforation with Double Guide Intubation Nimit Shah TCT Mechanical Thrombectomy Using Fogarty s Technique in Occlusion of the Left Main Coronary Artery in Acute Myocardial Infarction and Cardiogenic Shock Maria Antonieta De Medeiros TCT Use of Rotational Atherectomy in a Distal Undilatable Lesion After Proximal Stent Deployment in Chronic Total Occclusion Divyesh Sharma TCT Usefulness of Noncontrast Coronary Computed Tomography for Percutaneous Coronary Intervention of Chronic Total Occlusion Teppei Sugaya TCT Successful PCI for LAD Total Occlusion to Control Electrical Storm Mikio Kishi TCT Non-ST-Elevation Myocardial Infarction with Totally Occluded LAD with Lt. Main Bifurcated Lesion Hyunsu Kim TCT PCI to Distal Left Main Critical Stenosis Amr Hassan TCT A Hole New Experience Peter Haworth TCT Left Main Chronic Total Occlusion Treated with Single Stent: Simplifying the Complex Sarita Rao TCT Modified T-Stenting of a Bifurcation Lesion in LCX in a Patient with Severe Two Vessel CAD Balijepalli Sudhakar TCT A Forced Rotablator During Primary PCI Massimo Mancone TCT PCI with Multiple Complications: Impact of New Technologies in Successful Management Paramdeep Sandhu TCT IVUS-Guided Antegrade and Retrograde Complex Right Coronary Artery CTO-PCI Roberto Garbo TCT IVUS-Guided Retrograde Ostial LAD CTO-PCI Through Tortuous Epicardial Collateral Roberto Garbo TCT Common Complication with Uncommon Solution Wirash Kehasukcharoen TCT LMCA Stenting: Reverse Minicrush Technique Ashwin Tumkur TCT Antegrade Approach to 14-Year- Old Long and Calcified CTO Complicated by Stent/Balloon Perforation Ashwin Mehta TCT Successful Antegrade PCI for LAD-CTO Using Reverse Wire Technique Hiroki Watanabe TCT First-in-Human Experience in the Dilatation, Capture, and Removal of Atheromatous Plaque, from the Lesion Site, Post-Directional Atherectomy with the New 0.14 Below-the-Knee Proteus Balloon in the Treatment of High-Risk Critical Limb Ischemia Patient Prakash Makam TCT Huge Thrombus Burden in a STEMI: When Aspiration Catheters Do Not Help! Narasimharajapura Rajendra Afternoon Spotlight Sessions Deep Dive: Hypertension and Renal Artery Denervation 2:00 pm-6:26 pm Room A Session I. Renal Denervation: Rationale and Preclinical Science Moderators: Justin E. Davies, Krishna J. Rocha-Singh Discussants: Juan F. Granada, Markus P. Schlaich, Robert S. Schwartz 2:00 pm - Resistant Hypertension: Prevalence and Global Impact Stefan C. Bertog 2:10 pm - Physiologic Rationale for Interventional Therapies in Hypertension C. Venkata S. Ram 2:20 pm - Translational Medicine and Renal Denervation: Preclinical Animal Models and Histoanatomy Renu Virmani 2:30 pm - Discussion with Q&A Session II. Clinical Endpoints and Trial Design in Renal Denervation Moderators: Deepak L. Bhatt, Justin E. Davies Discussants: Herbert D. Aronow, Paul A. Sobotka, Thomas Zeller 2:40 pm - Measuring the Clinical Effects of Renal Denervation: Are Office Blood Pressure and 24-Hour Ambulatory Blood Pressure Monitoring the Best Surrogates? Paul A. Sobotka 2:50 pm - Three-Year Results from SYMPLICITY HTN-1 and SYMPLICITY HTN-2: What the Data Do (and Don t) Tell Us Michael Böhm Debate: Is a Sham Trial Really Necessary? 3:05 pm - SYMPLICITY Results Are Too Good to Be True: That s Why We Need a Sham Trial Design! Darrel P. Francis 3:13 pm - Sham Trials Are Burdensome and Introduce Their Own Errors! Deepak L. Bhatt 3:21 pm - Discussion with Q&A Session III. Real-world Experiences with Renal Denervation Moderators: Felix Mahfoud, Horst Sievert Discussants: Klaus D. Mathias, Dierk Scheinert, Terje K. Steigen 3:31 pm - Lessons Learned Using the Symplicity Catheter 1: Procedural Do s and Don ts Andreas Baumbach 3:41 pm - Lessons Learned Using the Symplicity Catheter 2: Complex Anatomy and Case Selection Erwin Blessing 3:51 pm - The Clinical Use of Renal Denervation Is Already Expanding Beyond Trial Indications: Insights from the German GREAT Registry Felix Mahfoud 3:59 pm - Discussion with Q&A Session IV. Emerging Technologies for Renal Denervation Moderators: Erwin Blessing, Horst Sievert Discussants: Todd J. Brinton, John M. Flack, Krishna J. Rocha-Singh 130

133 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics 4:09 pm - Properties of My Dream Device Horst Sievert 4:14 pm - Sympathetic Renal Denervation: Results of the EnligHTN I Study (St. Jude Medical) Vasilios Papademetriou 4:21 pm - Paradise (ReCor) Karl-Heinz Kuck 4:28 pm - V2 (Vessix Vascular) James R. Margolis 4:35 pm - Sound Intervention Vivek Y. Reddy 4:42 pm - TIVUS (CardioSonic) Dierk Scheinert 4:47 pm - OneShot (Maya Medical) John A. Ormiston 4:52 pm - External Focused Ultrasound (Kona) Todd J. Brinton 4:59 pm - Extravascular Renal Denervation (Ablative Solutions) Tim A. Fischell 5:04 pm - Vincristine Local Delivery for Renal Artery Denervation Christodoulos I. Stefanadis 5:09 pm - Discussion with Q&A Session V. Future Targets and Trials for Renal Sympathetic Denervation Moderators: Felix Mahfoud, Paul A. Sobotka Discussant: Darrel P. Francis 5:19 pm - Systolic and Diastolic Heart Failure Justin E. Davies 5:29 pm - Moderate Hypertension and ESRD Markus P. Schlaich 5:39 pm - Diabetes/Metabolic Syndrome Felix Mahfoud 5:49 pm - Obstructive Sleep Apnea Adam Witkowski 5:59 pm - Beyond Renal Denervation Paul A. Sobotka 6:09 pm - Hypertension Therapies: A Word of Caution Peter J. Fitzgerald 6:21 pm - Discussion with Q&A 6:26 pm - Adjourn Next-Generation Transcatheter Aortic Valve Therapies 2:00 pm-6:15 pm Room A This session is only CME accredited. New TAVR Systems I. New and Iterative Creations from the TAVR Industry Leaders Moderators: Josep Rodes-Cabau, Stephan Windecker Discussants: Vasilis Babaliaros, Todd M. Dewey, Gregory P. Fontana, Eberhard Grube, Jean-Claude Laborde, Augusto D. Pichard, E. Murat Tuzcu, Nicolas M. van Mieghem 2:00 pm - Do We Need New and Evolutionary TAVR Systems? Rationale and Critical Design Features Nicolo Piazza 2:08 pm - Discussion Edwards Lifesciences 2:10 pm - Next-Generation Balloon- Expandable Technology: SAPIEN 3 Josep Rodes-Cabau 2:20 pm - A Novel Self-Expanding TAVR System: CENTERA Karl-Heinz Kuck 2:30 pm - A Novel Balloon-Expandable TAVR System for Aortic Regurgitation Jian Ye 2:35 pm - New Expandable Sheaths and TA Systems Isaac George 2:40 pm - Discussion Medtronic 2:45 pm - Next-Generation Self-Expanding Technology: CoreValve Evolut and Beyond Eberhard Grube 2:55 pm - The Next-Generation Engager TAVR System Hendrik Treede 3:05 pm - New TAVR Accessory Devices Lutz Buellesfeld 3:10 pm - Discussion New TAVR Systems II. Newcomers With Significant Clinical Experiences Moderators: Raj Makkar, Ganesh Manoharan Discussants: Stephan M. Ensminger, Isaac George, Reginald I. Low, Ian T. Meredith, Helge Moellmann, Martyn R. Thomas, Hendrik Treede 3:15 pm - Direct Flow Medical TAVR System Joachim Schofer 3:25 pm - Discussion Symetis Acurate TAVR System 3:30 pm - Updates from the Transapical Program Hendrik Treede 3:38 pm - Updates from the Transfemoral Program Helge Moellmann 3:46 pm - Discussion JenaValve and St. Jude Medical 3:51 pm - JenaValve TAVR System Stephan M. Ensminger 4:01 pm - Discussion 4:06 pm - St. Jude Medical Portico TAVR System Raj Makkar 4:16 pm - Discussion 4:21 pm - Boston Scientific Sadra Lotus TAVR System Ian T. Meredith 4:31 pm - Discussion New TAVR Systems III. Newcomers Without Significant Clinical Experiences Moderators: Raj Makkar, Ganesh Manoharan Discussants: Maurice Buchbinder, Lutz Buellesfeld, Michael J. Davidson, Hans R. Figulla, Nicolo Piazza, Gerhard C. Schuler, Nicolas M. van Mieghem 4:36 pm - Heart Leaflet Technologies TAVR System Gerhard C. Schuler 4:41 pm - Colibri Heart Valve System Ziyad M. Hijazi 4:46 pm - Valve Medical TAVR System Martin B. Leon 4:51 pm - Endoluminal Sciences: A New Concept for Eliminating Paravalvular Regurgitation Raj Makkar 4:56 pm - Discussion Cerebral Protection Devices and Vascular Access and Closure Moderators: Eberhard Grube, Samir R. Kapadia Discussants: Philippe Généreux, Joerg Kempfert, Christoph K. Naber, Josep Rodes-Cabau, Eric E. Roselli, Pieter R. Stella Cerebral Protection 5:02 pm - Will Cerebral Embolic Protection Devices Reduce Strokes After TAVR? Samir R. Kapadia 5:10 pm - Embrella Embolic Deflector: Clinical Experiences and PROTAVI Update Josep Rodes-Cabau Wednesday - October 24,

134 Wednesday, October 24 5:18 pm - Claret Medical Montage Cerebral Filter: Clinical Experiences Eberhard Grube 5:26 pm - Keystone Heart Embolic Deflector: Clinical Experiences Pieter R. Stella 5:34 pm - Discussion vascular Access and Closure 5:39 pm - The Landscape of Transarterial Large Hole Vascular Closure Devices Peter J. Fitzgerald 5:49 pm - Novel Transapical Left Ventricular Access and Closure Devices Martin B. Leon 5:55 pm - Early First-in-Human Use Experiences with the Apica Transapical Access and Closure System Joerg Kempfert 6:01 pm - Early First-in-Human Use Experiences with the Entourage Transapical Access and Closure System Gregory P. Fontana 6:05 pm - Discussion 6:15 pm - Adjourn Optimizing Use of Today s Antithrombotic and Antiplatelet Drugs in ACS and PCI 2:00 pm-6:10 pm Room A Session I. Trial and Drug Update Moderators: David J. Moliterno, E. Magnus Ohman Discussants: C. Michael Gibson, Robert A. Harrington, Roxana Mehran, Harvey D. White 2:00 pm - Bivalirudin: New Analyses, New Studies Gregg W. Stone 2:10 pm - The Potential of Otamixaban as a Procedural Anticoagulant Philippe Gabriel Steg 2:20 pm - Prasugrel Update: TRILOGY E. Magnus Ohman 2:30 pm - Ticagrelor Update: PLATO: Recent Analyses Robert A. Harrington 2:40 pm - Cangrelor Update: CHAMPION PHOENIX Harvey D. White 2:50 pm - Rivaroxaban Update: ATLAS-ACS-2 TIMI-51: Recent Analyses and FDA Redux C. Michael Gibson 3:00 pm - Factor IXa Inhibition (Aptamer) Update Roxana Mehran 3:10 pm - GP IIb/IIIa Inhibition: New Studies, New Insights David J. Moliterno 3:20 pm - Discussion with Q&A Session II. Pharmacology Debates Moderators: Sorin J. Brener, George D. Dangas Discussants: Michael Kim, Steven P. Marso, Jessica L. Mega, Franz-Josef Neumann, Michelle O Donoghue, Duk-Woo Park, Dirk Sibbing Debate I. At Least 12 Months of Dual Antiplatelet Therapy for All DES Patients 3:40 pm - Pro! Duane S. Pinto 3:50 pm - Con! Hyeon-Cheol Gwon 4:00 pm - Rebuttal and Discussion with Q&A Debate II. Utility of Genetic Testing in Picking Antiplatelet Therapy 4:10 pm - Pro! Jessica L. Mega 4:20 pm - Con! Franz-Josef Neumann 4:30 pm - Rebuttal and Discussion with Q&A Debate III. Utility of Point-of-Care Platelet Function Testing 4:40 pm - Pro! Matthew J. Price 4:50 pm - Con! Duk-Woo Park 5:00 pm - Rebuttal and Discussion with Q&A Session III. Great Cases Moderators: Neal S. Kleiman, A. Michael Lincoff Discussants: Dominick J. Angiolillo, Lisa K. Jennings, David F. Kong, Issam D. Moussa, Harvey D. White 5:10 pm - Case 1: Peri-PCI Management of the Recently Placed Stent George D. Dangas 5:25 pm - Case 2: Peri- and Post-Procedural Management of the Patient with Stent Thrombosis Sorin J. Brener 5:40 pm - Case 3: The Patient with a Recently Placed DES in Need of Emergent Major Surgery Harold L. Dauerman 5:55 pm - Case 4: The Patient with Atrial Fibrillation Presenting with an Acute Coronary Syndrome Michael D. Ezekowitz 6:10 pm - Adjourn Surgical, Interventional, and Hybrid Procedures (Part 2): Valvular and Structural Heart Disease Co-sponsored by the American Association for Thoracic Surgery 2:00 pm-6:15 pm Junior Ballroom D This session is only CME accredited. Session I. Transfemoral and Alternate Access for TAVR Moderators: Wilson Y. Szeto, Martyn R. Thomas Discussant: Michael J. Reardon 2:00 pm - As Transfemoral Devices Become Smaller, Will There Be a Role for Alternative Access? Martyn R. Thomas 2:10 pm - Statement: Transaortic Access Is Preferable to Transapical Access! Michael J. Reardon 2:20 pm - Percutaneous Femoral Artery Closure During TAVR Philippe Généreux 2:30 pm - Non-TAVR Procedures Performed via a Transapical Approach Wilson Y. Szeto 2:40 pm - Discussion with Q&A Session II. TAVR Potpourri Moderators: Ian T. Meredith, Wilson Y. Szeto Discussants: Vinayak Bapat, Eberhard Grube, Charanjit S. Rihal, Rhonda Robb 2:50 pm - Valve-in-Valve for Failed Bioprosthetic Valves Vinayak Bapat 3:00 pm - Percutaneous Closure of TAVR Paravalvular Leaks Charanjit S. Rihal 3:10 pm - Off-Label Use of the Edwards Sapien RF3 System in the United States Wilson Y. Szeto 3:20 pm - TAVR Trends in Europe and What to Expect in the Future Rhonda Robb 3:30 pm - TAVR: Next-Generation Devices Josep Rodes-Cabau 3:40 pm - Discussion with Q&A 132

135 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics Session III. Transcatheter Mitral Valve Procedures Moderators: A. Marc Gillinov, Saibal Kar Discussants: Stephan Baldus, A. Pieter Kappetein, Francesco Maisano, Neil E. Moat, Jason H. Rogers 3:50 pm - Multidisciplinary Approach to Mitral Valve Disease Neil E. Moat 4:00 pm - A Surgeon s Candid Experience with the MitraClip Francesco Maisano 4:10 pm - MitraClip for Functional MR: COAPT: Update and Expectations Gregg W. Stone 4:15 pm - MitraClip for Functional MR: RESHAPE Update and Expectations A. Pieter Kappetein 4:20 pm - Atypical Pathology Treated with the MitraClip Stephan Baldus 4:30 pm - Transcatheter Mitral Valve Devices on the Horizon Jason H. Rogers 4:40 pm - Discussion with Q&A Session IV. Valve Surgery Updates Moderators: A. Marc Gillinov, A. Pieter Kappetein Discussants: David H. Adams, Emile Bacha, Steven F. Bolling, James S. Gammie, Allan Stewart 4:50 pm - Is Aortic Valve Repair Superior to Replacement? Allan Stewart 5:00 pm - The Role of Hybrid Procedures in Congenital Heart Surgery Emile Bacha 5:10 pm - Minimally Invasive Mitral Repair: Is It for Everyone (Surgeon and Patient)? A. Marc Gillinov 5:20 pm - Artificial Chords: When and How? James S. Gammie 5:30 pm - Who Should Have a Mitral Valve Replacement? Steven F. Bolling 5:40 pm - Tricuspid Valve Repair: When and How? David H. Adams 5:50 pm - The Impact of a TAVR Program on Surgical Volume A. Pieter Kappetein 6:00 pm - Discussion with Q&A 6:15 pm - Adjourn The Skeptic s Corner: Controversies in Interventional Cardiology 2:00 pm-5:40 pm Room A This session is only CME accredited. Panel I. Interventional Cardiology and Surgery at the Crossroads Moderators: Eric R. Bates, Craig R. Smith Discussants: David Brown, Maurice Buchbinder, James S. Gammie, Philippe Garot, Robert A. Guyton, Sanjay Kaul, Ajay J. Kirtane, Vincent On-Hing Kwok, Harold L. Lazar, Daniel I. Simon Commonly Held View 1: ASCERT is Right! CABG Provides Optimal Revascularization for Stable Multivessel CAD 2:00 pm - Contrarian Position: ASCERT Is Hopelessly Confounded. PCI Outcomes Are No Worse, and PCI Is More Widely Acceptable and Applicable! Christopher J. White 2:10 pm - Discussion with Q&A Commonly Held View 2: PCI for Left Main Disease Is Skating on Thin Ice! 2:22 pm - Contrarian Position: Left Main PCI Will Make CABG Obsolete! Sheldon Goldberg 2:32 pm - Discussion with Q&A Commonly Held View 3: Mitral Regurgitation Is a Surgical Disease 2:44 pm - Contrarian Position: Interventional Devices Will Soon Be Able to Manage the Spectrum of Mitral Pathology! Howard C. Herrmann 2:54 pm - Discussion with Q&A Commonly Held View 4: TAVR Will Change the Treatment Landscape for Aortic Stenosis 3:06 pm - Contrarian Position: More Strokes, Vascular Complications, Unknown Durability: Not So Fast! Lawrence H. Cohn 3:16 pm - Discussion with Q&A Commonly Held View 5: Carotid Artery Stenting Should Not Be the Standard of Care for Asymptomatic Carotid Artery Disease 3:28 pm - Contrarian Position: Evidence- Based Nonsense! Max Amor 3:38 pm - Discussion with Q&A Panel II. Interventional Cardiology and Pharmacotherapy Controversies Moderators: Sanjay Kaul, Daniel I. Simon Discussants: Eric R. Bates, Donald Cutlip, James A. Goldstein, Ajay J. Kirtane, Guy LeClerc, Chaim S. Lotan, Roxana Mehran, Tabassome Simon, Mohamed Sobhy Commonly Held View 6: There Is Insufficient Evidence to Recommend Genetic and Platelet Function Testing Post Coronary Stenting 3:50 pm - Contrarian Position: Get Your Heads Out of the Sand! Genomics and Platelet Function Testing Will Revolutionize Tailored Antiplatelet Therapy! Matthew J. Price 4:00 pm - Discussion with Q&A Commonly Held View 7: Left Atrial Appendage Occlusion Devices Can Never Match Up to Oral Anticoagulants 4:12 pm - Contrarian Position: Oral Anticoagulants Introduce More Problems Than They Solve! Greg Mishkel 4:22 pm - Discussion with Q&A Commonly Held View 8: FFR Should Replace Clinical Judgment and Noninvasive Stress Testing Pre-PCI in Stable CAD 4:34 pm - Contrarian Position: People Who Make These Statements Don t Take Care of Patients (or Read the Literature Carefully)! Jeffrey W. Moses 4:44 pm - Discussion with Q&A Commonly Held View 9: Rivaroxaban Plus Dual Antiplatelet Therapy Will Optimize Pharmacotherapy for ACS 4:56 pm - Contrarian Position: A Case of Enthusiasm Exceeding the Evidence! Matthew T. Roe 5:06 pm - Discussion with Q&A Commonly Held View 10: Dual Antiplatelet Therapy Post Stenting Should Be Given for at Least One Year if Not Longer 5:18 pm - Contrarian Position: Evidence Is Leaning Towards Shorter Treatment Duration Tullio Palmerini 5:28 pm - Discussion with Q&A 5:40 pm - Adjourn Evening Programs 7:00 pm-8:30 pm Please see page 171 for the Evening Programs schedule. Wednesday - October 24,

136 CardiovasC ular r esearc h Foundation Clinical Trials Center Experts in Design, Core Laboratories, and Regulatory Support Medical research is a continuum that begins with a promising concept and concludes with proving the safety and efficacy of a new therapy in a controlled clinical trial. CRF s Clinical Trials Center provides comprehensive and complete trial design, evaluation, and analysis services. The Clinical Trials Center (CTC) sets the standard for conducting clinical research, offering a full spectrum of interventional and pharmacological evaluations with unmatched expertise. The CTC combines the comprehensive knowledge of leading physicians and technologists to streamline the research process from Phase I through Phase IV trials. The CTC provides the full spectrum of services needed for successful clinical research, including clinical and regulatory strategy, protocol and database development, statistical analysis, safety surveillance, and core laboratory capabilities. This full portfolio of abilities means our clients can have a tailored research plan that meets their needs. Contact us: Business Development CRF Clinical Trials Center Tel: [email protected] Visit us at booth 595 located in Exhibit Hall. CARDIOVASCULAR RESEARCH FOUNDATION a passion for innovation

137 Breakfast Meetings Main Arena How to Treat Theater: Coronary Artery Disease How to Treat Theater: Structural Heart and Endovascular Disease International Multiplex Theater Challenging Case Theater Challenging Case Theater Maintenance of Certification (MOC) Course Special Sessions FDA Town Hall Meeting TCT: An Integrated Course for Surgeons and Interventionalists Morning Spotlight Sessions Alcohol Septal Ablation Symposium Aortic Aneurysm Repair and Stent-Graft Devices Integrating IVUS and FFR into Clinical Practice Primary PCI for STEMI: Drugs, Devices, and Technique Controversies Edited Taped Case Presentations Challenging Case Video Presentations Presentation Theater Lunchtime Sessions Hot Topics Learn the Technique Challenging Case Video Presentations Thursday October 25, 2012 Miami Beach Convention Center miami, FL Afternoon Spotlight Sessions Drug-Coated Balloons (DCB): Clinical Data and Applications International Debating Chamber: Interventional Cardiology on Trial Next-Generation Intravascular Imaging and Physiology: RF-IVUS, OCT, NIR Spectroscopy, ifr, and CT-FFR Evening Programs The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics

138 Thursday, October 25 Breakfast Meetings 7:00 am-8:00 am Please see page 173 for the Breakfast Meeting schedule. Main Arena 8:00 am-6:00 pm Hall D Plenary Session XII. Live Cases IV Live Case Moderator: Gregg W. Stone Live Case Co-Moderator: Antonio Colombo Live Case Discussants: Steven L. Almany, Simon R. Dixon, Dariusz Dudek, David P. Faxon, Run-Lin Gao, Christian W. Hamm, Marie-Claude Morice, John A. Ormiston, Ashok Seth, Gerald S. Werner, Stephan Windecker 8:00 am - Cardiovascular Centre, ZNA Middelheim Hospital Antwerp, Belgium 8:45 am - Cardiovascular Center Aalst Aalst, Belgium Plenary Session XIII. Clinical Trial Design and Interpretation Moderators: Stuart J. Pocock, Gregg W. Stone Discussants: John D. Carroll, Donald Cutlip, Pamela S. Douglas, David R. Holmes Jr, Stefan K. James, Neal S. Kleiman, Sunil V. Rao, Patrick W. Serruys, William S. Weintraub, Stephan Windecker 9:30 am - The Misinterpretation of Clinical Trials: Common Errors and Case Examples Sanjay Kaul Increased Importance of Large Registries 9:45 am - Part 1: Evolving Lessons from the Swedish National SCARR Registry Stefan K. James 9:55 am - Part 2: Will the Transcatheter Valve Therapy Registry Transform US Regulatory Strategies? David R. Holmes Jr 10:05 am - Discussion Plenary Session XIV. TCT 2012 Game-Changing Therapies II. Is Interventional Heart Failure the Next Big Breakthrough? Moderators: William T. Abraham, Robert D. Dowling Discussants: Daniel Burkhoff, Neal L. Eigler, Francisco Fernandez-Aviles, Timothy D. Henry, Navin K. Kapur, Joseph G. Rogers, Warren Sherman, Marvin J. Slepian, Jochen W öhrle, Andreas M. Zeiher 10:15 am - Novel Device-Based Therapies for Advanced Heart Failure Daniel Burkhoff 10:25 am - Does Chronic Indwelling Pressure Monitoring in Heart Failure Represent a True Paradigm Shift? William T. Abraham 10:35 am - Stem Cell Strategies for Myocardial Repair: Predicting the Future Francisco Fernandez-Aviles 10:45 am - Discussion Plenary Session XV. TCT 2012 Career Achievement Award Moderator: Martin B. Leon 11:00 am - TCT 2012 Career Achievement Award Award Presenter: Martin B. Leon Award Recipient: Renu Virmani Plenary Session XVI. Late Breaking Trials II Moderator: Gregg W. Stone Co-Moderator: David R. Holmes Jr Discussants: David P. Faxon, Christian W. Hamm, Robert A. Harrington, William W. O Neill, John F. Rhodes, David E. Thaler, Pascal Vranckx, Brian K. Whisenant 11:15 am - RESPECT: A Prospective, Randomized Trial of PFO Closure vs. Medical Therapy in Patients with Cryptogenic Stroke John D. Carroll 11:27 am - The PC Trial: A Prospective, Randomized Trial of PFO Closure vs. Medical Therapy in Patients with Cryptogenic Embolism Stephan Windecker 11:39 am - Discussion 11:55 am - A Prospective, Randomized Trial of Sliding-Scale Hydration for Prevention of Contrast Nephropathy Somjot S. Brar 12:07 pm - Discussion Plenary Session XVII. First Report Investigations II Moderator: Antonio Colombo Co-Moderator: Daniel I. Simon Discussants: Upendra Kaul, Neal S. Kleiman, Mitchell W. Krucoff, Frederick Kushner, Steven V. Manoukian, Julinda Mehilli, Philip M. Urban, Alan C. Yeung 12:15 pm - ADAPT-DES One Year: A Large-Scale, Multicenter, Prospective, Observational Study of the Impact of Clopidogrel and Aspirin Hyporesponsiveness on Patient Outcomes Gregg W. Stone 12:25 pm - Discussion 12:30 pm - AIDA STEMI MRI: Cardiac MRI Substudy from a Prospective, Randomized Trial of Intracoronary Abciximab in Patients with ST-Segment Elevation Myocardial Infarction Holger Thiele 12:40 pm - Discussion 12:45 pm - A Prospective, Randomized Trial of Post-Conditioning in Patients with ST-Segment Elevation Myocardial Infarction Joo-Yong Hahn 12:55 pm - Discussion Plenary Session XVIII. Live Cases V Live Case Moderator: Martin B. Leon Live Case Co-Moderator: Ted E. Feldman Live Case Discussants: Jorge A. Belardi, Donald Cutlip, Mark A. de Belder, John S. Douglas Jr, Stephen G. Ellis, Jacques J. Koolen, Paul H. Kramer, John M. Lasala, Francesco Maisano, Doff B. McElhinney, Sigmund Silber 1:00 pm - Nationwide Children s Hospital Columbus, OH 1:45 pm - Swedish Health Services Seattle, WA 136

139 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics Plenary Session XIX. Adjunctive Pharmacology Spotlight Moderators: E. Magnus Ohman, Harvey D. White Discussants: Dominick J. Angiolillo, Laurent Bonello, C. Michael Gibson, Christopher B. Granger, Robert A. Harrington, Dean J. Kereiakes, Ajay J. Kirtane, David J. Moliterno, Matthew J. Price, Daniel I. Simon, Stephen D. Wiviott A Plethora of New Drugs: Meaningful Differences and Clinical Use Recommendations 2:30 pm - Part 1: Oral Anticoagulants Christopher B. Granger 2:40 pm - Part 2: Antiplatelet Agents Robert A. Harrington 2:50 pm - Discussion Platelet Resistance and Genetic Testing: Shifting Tides 3:00 pm - Part 1: Justifying My Guidelines: Selective but Important Value Matthew J. Price 3:10 pm - Part 2: Only a Research Tool Ajay J. Kirtane 3:20 pm - Discussion Plenary Session XX. Live Cases VI Live Case Moderator: Gregg W. Stone Live Case Co-Moderator: Patrick W. Serruys Live Case Discussants: Steven R. Bailey, John D. Carroll, Howard C. Herrmann, Saibal Kar, Dean J. Kereiakes, Christoph A. Nienaber, Manish A. Parikh, Jason H. Rogers, Carlos E. Ruiz, Leif Thuesen, Jonathan M. Tobis 3:30 pm - Rush University Medical Center Chicago, IL 4:15 pm - NewYork-Presbyterian Hospital/ Columbia University Medical Center Plenary Session XXI. Structural Heart Disease Controversies Moderators: Howard C. Herrmann, John F. Rhodes Discussants: David H. Adams, Stephen J.D. Brecker, Ted E. Feldman, James B. Hermiller Jr, Eric Horlick, Saibal Kar, Carlos Pedra, Vivek Y. Reddy, Charanjit S. Rihal, Peter Sick, Horst Sievert, Brian K. Whisenant 5:00 pm - The Complex Landscape of Interventional Mitral Valve Therapies: Present Status and Future Directions Ted E. Feldman 5:15 pm - Has PFO Closure for Stroke Prevention Finally Gotten Enough RESPECT? Jonathan M. Tobis 5:30 pm - Will Transcatheter Left Atrial Appendage Closure Transform Management of Atrial Fibrillation? Vivek Y. Reddy 5:45 pm - Discussion 6:00 pm - Adjourn How to Treat Theater: Coronary Artery Disease 7:50 am-6:00 pm Hall A-Coronary Theater This session is only CME accredited. Multivessel and Diffuse Disease Intervention I Moderator: David J. Cohen Co-Moderator: David O. Williams 8:00 am - When Is PCI Justified in Complex (Non-Left Main) Multivessel Disease with Current Drug-Eluting Stents? Dean J. Kereiakes 8:15 am - Ischemic vs. Anatomical Revascularization: How to Improve PCI Outcomes Pim A.L. Tonino Live Cases: Multivessel and Diffuse Disease Intervention I Live Case Moderator: David J. Cohen Live Case Co-Moderator: David O. Williams Live Case Discussants: Fernando Alfonso, Didier Carrié, Michael J. Cowley, David A. Cox, Debabrata Dash, Karel T. Koch, Jacek Legutko, Sunao Nakamura, Duk-Woo Park 8:30 am - CARE Hospitals Hyderabad, India 9:30 am - Cardiovascular Centre, ZNA Middelheim Hospital Antwerp, Belgium Multivessel and Diffuse Disease Intervention II Moderator: Patrick W. Serruys Co-Moderator: Nico H.J. Pijls 10:30 am - Ten Practical Tips and Tricks to Enhance PCI Outcomes in Complex Coronary Disease Antonio Colombo 10:45 am - Optimizing Adjunct Pharmacotherapy Before, During, and After PCI: An Evidence-Based Tutorial C. Michael Gibson Live Cases: Multivessel and Diffuse Disease Intervention II Live Case Moderator: Patrick W. Serruys Live Case Co-Moderator: Nico H.J. Pijls Live Case Discussants: Vinay K. Bahl, Sripal Bangalore, Erwin Blessing, Mauricio G. Cohen, Pedro A. Lemos, Ahmed Magdy, Expedito E. Ribeiro, Alfredo Rodriguez, Simon Walsh 11:00 am - Cardiovascular Center Aalst Aalst, Belgium 12:00 pm - Royal Sussex County Hospital Brighton, United Kingdom Complex and Unusual Coronary Intervention I Moderator: Ian T. Meredith Co-Moderator: David R. Holmes Jr 1:00 pm - Frequency, Prevention, and Management of DES Thrombosis Ajay J. Kirtane 1:15 pm - Evaluation and Treatment of In-Stent Restenosis Christoph A. Kaiser Live Cases: Complex and Unusual Coronary Intervention I Live Case Moderator: Ian T. Meredith Live Case Co-Moderator: David R. Holmes Jr Live Case Discussants: Sorin J. Brener, Louis A. Cannon, Pavel Cervinka, Eric A. Cohen, Ozgen Dogan, Vladimír Džavík, Thomas A. Ischinger, Samuel K. Mathew, Samin K. Sharma 1:30 pm - Royal Sussex County Hospital Brighton, United Kingdom 2:30 pm - Fundación Favaloro Buenos Aires, Argentina Complex and Unusual Coronary Intervention II Moderator: George D. Dangas Co-Moderator: Ulrich Sigwart 3:30 pm - Primary PCI: Current Procedural Controversies and Decision-Making Michel R. Le May 3:45 pm - The Spectrum of Hemodynamic Support (from IABP to ECMO): How to Choose and Use Holger Thiele Thursday - October 25,

140 Thursday, October Live Cases: Complex and Unusual Coronary Intervention II Live Case Moderator: George D. Dangas Live Case Co-Moderator: Ulrich Sigwart Live Case Discussants: Ziad A. Ali, Olivier F. Bertrand, John A. Bittl, Joseph P. Carrozza Jr, Graham A. Cassel, Harold L. Dauerman, Gennaro Sardella, Bradley H. Strauss, Jose M. de la Torre Hernandez 4:00 pm - Mount Sinai Medical Center Miami, FL 5:00 pm - Fundación Favaloro Buenos Aires, Argentina 6:00 pm - Adjourn How to Treat Theater: Structural Heart and Endovascular Disease 8:00 am-6:00 am Hall A-Structural and Endovascular Theater This session is only CME accredited. Carotid and Neurointervention Moderator: Jay S. Yadav Co-Moderator: Klaus D. Mathias 8:00 am - Carotid Artery Stenting 2012: An Analytical Look at the Therapy and Its Place in the Management of Severe Carotid Stenosis Peter A. Schneider 8:15 am - Interventional Therapy of Acute Stroke: Current Indications, Tools, and Outcomes Alex Abou-Chebl Live Cases: Carotid and Neurointervention Live Case Moderator: Jay S. Yadav Live Case Co-Moderator: Klaus D. Mathias Live Case Discussants: Alex Abou-Chebl, Herbert D. Aronow, Tony Das, Carmelo Grasso, Zaza Kavteladze, D. Christopher Metzger, Juan C. Parodi, Fayaz Shawl, Eugenio Stabile 8:30 am - Baptist Cardiac and Vascular Institute Miami, FL 9:30 am - NewYork-Presbyterian Hospital/ Columbia University Medical Center Adult Congenital Intervention I Moderator: Eric Horlick Co-Moderator: Peter C. Block 10:30 am - Role of ICE and 3-D Echo for Interventional Procedures Frank E. Silvestry 10:45 am - Patient Selection for PFO Closure: Who Should Be Treated Always, Sometimes, and Never? Jonathan M. Tobis Live Cases: Adult Congenital Intervention I LIve Case Moderator: Eric Horlick LIve Case Co-Moderator: Peter C. Block Live Case Discussants: Stephen J.D. Brecker, Patrick A. Calvert, Marc D. Feldman, Frank F. Ing, Saibal Kar, Eustaquio Maria Onorato, Marlon Rosenbaum, On Topaz, Nicolas M. van Mieghem 11:00 am - CARE Hospitals Hyderabad, India 12:00 pm - NewYork-Presbyterian Hospital/ Columbia University Medical Center Adult Congenital Intervention II Moderator: John F. Rhodes Co-Moderator: Horst Sievert 1:00 pm - Outcomes of ASD Closure with a Deficient Rim Frank F. Ing 1:10 pm - Has Progress Been Made with Post-MI VSD Closure? Eustaquio Maria Onorato 1:20 pm - Acute and Late Outcomes of Stenting for Coarctation (Covered and Uncovered) Lee N. Benson Live Cases: Adult Congenital Intervention II Live Case Moderator: John F. Rhodes Live Case Co-Moderator: Horst Sievert Live Case Discussants: Zahid Amin, Emile Bacha, Lee N. Benson, Steven L. Goldberg, David W.M. Muller, Igor F. Palacios, Peter Sick, Maarten J. Suttorp, Steven J. Yakubov 1:30 pm - Rush University Medical Center Chicago, IL 2:30 pm - Children s Hospital Columbus, OH Adult Congenital Intervention III Moderator: Doff B. McElhinney Co-Moderator: Bagrat Alekyan 3:30 pm - Coronary AV Fistula Closure: Indications, Techniques, and Outcomes Elchanan Bruckheimer 3:45 pm - Transcatheter Pulmonary Valve Replacement: Clinical Trials and Real-world Experiences William E. Hellenbrand Live Cases: Adult Congenital Intervention III Live Case Moderator: Doff B. McElhinney Live Case Co-Moderator: Bagrat Alekyan Live Case Discussants: Vasilis Babaliaros, William E. Hellenbrand, Michael Kim, Daniel J. McCormick, Srihari S. Naidu, Christopher D. Nielsen, Lynn F. Peng, Matthew J. Price, Negar Salehi, Daniel Soffer 4:00 pm - Swedish Health Services Seattle, WA 5:00 pm - Rush University Medical Center Chicago, IL 6:00 pm - Adjourn International Multiplex Theater These sessions are not CME/CNE accredited. Challenging Case Theater 1 8:00 am-5:00 pm Hall A-IMT 1 Treating Difficult Cases in the Cath Lab Co-sponsored by the Hellenic Cardiological Society and Cyprus Society of Cardiology 8:00 am-9:00 am Moderators: Panayiotis Avraamides, George Parcharidis Discussants: Georgios Georgiou, Themis Komodromos, Georgios Sianos, Konstantinos Toutouzas 8:00 am - Case 1: A 42-Year-Old Female with True Severe Resistant Hypertension Konstantinos P. Tsioufis 8:15 am - Case 2: Functional Assessment of Coronary Artery Stenosis After Coronary Artery Bypass Graft Ioannis (John) Kanakakis 8:30 am - Case 3: Complex Thrombus Management Panayiotis Avraamides 8:45 am - Case 4: Concominant Carotid and Coronary Disease Christos Christou

141 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics Hypothermia for Treatment of ST-Segment Elevation Myocardial Infarction Sponsored by the Swedish Society of Cardiology Working Group on Interventional Cardiology Moderators: Rikard B.A. Linder, Goran K. Olivecrona Discussants: Ole Frobert, Jens R. Jensen, Anders Jonsson, Elmir Omerovic 9:00 am - Case 1: Being Coldhearted Is Good When Taking Care of a Heart Attack! David Erlinge 9:15 am - Case 2: A Chilled Triple Dissection, It s Not a Drink! Ulf Jens Jensen 9:30 am - Case 3: Hypothermia Treatment in a Patient with Stress-Induced Cardiomyopathy and Cardiogenic Shock Petur Petursson 9:45 am - Case 4: Cardiac Arrest at an Outside Hospital, Management in Stockholm Risto Jussila Challenging Case Presentations in Interventional Cardiology Sponsored by the Iranian Society of Interventional Cardiology Moderators: Virendrasinh C. Chauhan, Mahmoud Hashemian Discussants: Seyed Mohammad Hassan Adel, Javad Kojuri, Majid Naghibzadeh Mashayekh 10:00 am - Case 1: PDA Closure in a Patient with Severe Pulmonary Hypertension Negar Salehi 10:15 am - Case 2: Complex CTO Intervention with the Crusade Device Seyed Ebrahim Kassaian 10:30 am - Case 3: ASD Closure with an IAS Aneurysm and Lack of Aortic Rim TBA 10:45 am - Case 4: Complicated LCA Bi-Ostial Lesion Intervention Iraj Firouzy Challenges in the Cath Lab Sponsored by the Sociedad de Cardiología Intervencionista de México Moderators: Joel Estrada Gallegos, Jos Alfredo Merino Rajme Discussants: Marco Alcantara, Felipe De Jesus Gonzalez Camid, Adrian Davila Bortoni, Fernando Huerta Liceaga 11:00 am - Case 1: Complex Coronary Intervention Arturo Abundes Velasco 11:15 am - Case 2: Carotid Intervention in a Complex Aortic Arch Felix Damas de los Santos 11:30 am - Case 3: Transhepatic Approach for Atrial Septal Defect Closure Homero A. Ramirez 11:45 am - Case 4: Endovascular Treatment of a Thoracoabdominal Aneurysm Luis R. Virgen Carrillo 12:00 pm - Break Interventional Challenges in Structural Heart Disease Sponsored by the Italian Society of Invasive Cardiology Moderators: Alberto Cremonesi, Angelo Ramondo Discussants: Mario Carminati, Arturo Giordano, Giovanni Sorropago, Gian Paolo Ussia 2:00 pm - Case 1: TAVI for Aortic Insufficiency: A Beneficial Spread Francesco Bedogni 2:15 pm - Case 2: Mitral Valve Bioprosthesis Degeneration with Perivalvular Leak: When One Door Closes, Another Opens Sergio Berti 2:30 pm - Case 3: How Can You Mend a Broken Heart? Francesco Meucci 2:45 pm - Case 4: Percutaneous Mitral Valve Repair: Clipping the Wings to Make Them Fly Carmelo Grasso PCI in Acute Coronary Syndromes: Interesting Cases from Malaysia Live Sponsored by the Interventional Cardiovascular Society of Malaysia Moderators: Kenneth Chin, Mohd Ali Rosli Discussants: G.H. Choo, Muda Nasir, Kui-Hian Sim, Robaayah Zambahari 3:00 pm - Case 1: PCI in a Thrombotic Lesion Kui-Hian Sim 3:15 pm - Case 2: Double Balloon Nightmare: Percutaneous Transseptal Mitral Commissurotomy and PCI Robaayah Zambahari 3:30 pm - Case 3: STEMI with Cardiogenic Shock in a Young Man Mohd Ali Rosli 3:45 pm - Case 4: Primary PCI for Left Main STEMI With Cardiogenic Shock G.H. Choo TAVR Nightmares Sponsored by the Cardiac Society of Australia and New Zealand Moderators: David W.M. Muller, Darren L. Walters Discussants: Ian T. Meredith, John A. Ormiston 4:00 pm - Case 1: Late Prosthesis Embolization David Smyth 4:15 pm - Case 2: Valve-in-Valve Implantation for Annular Rupture Martin Ng 4:30 pm - Case 3: Device Embolization During Direct Aortic Valve Implantation Darren L. Walters 4:45 pm - Case 4: Thoracic Aortic Dissection During Aortic Valve Implantation Ajay Radheshyam Sinhal 5:00 pm - Adjourn Challenging Case Theater 2 8:00 am-5:00 pm Hall A-IMT 2 High-Risk Patients and High-Risk Lesions: How to Treat Sponsored by the Egyptian Society of Cardiology Moderators: Khairy Abdel Dayem, Mohamed Sobhy Discussants: Ihab Attia, Adel El Etriby, Ayman Magd, Ashraf Reda 8:00 am - Case 1: Primary PCI for AMI: Which Is the Infarct Artery? Sherif El Beltagy 8:15 am - Case 2: A Complex Rescue PCI Amr Mahmoud Zaki 8:30 am - Case 3: CTO: Should I Stay or Should I Go? El Sayed Farag 8:45 am - Case 4: Same Patient, Same Artery, Same Doctor, What s New? Hany Ragy Complex Coronary Intervention: Case Presentations Sponsored by the Japanese Association of Cardiovascular Intervention and Therapeutics Moderators: Takeshi Kimura, Masato Nakamura Discussants: Yutaka Hikichi, Shunichi Miyazaki, Koichi Nakao, Takafumi Ueno 9:00 am - Case 1: FFR Decision-Making in a Patient with Left Main Disease and Atrial Septal Defect Naoto Inoue 9:15 am - Case 2: IVUS-Guided Reverse CART Yasushi Asakura 9:30 am - Case 3: Transradial Retrograde Approach for a Chronic Total Occlusion Yuji Ikari Thursday - October 25,

142 Thursday, October 25 9:45 am - Case 4: Culotte Stenting of a Left Main Distal Bifurcation Lesion Kazushige Kadota Complex Management Options in TAVR Sponsored by the Israel Heart Society Working Group on Interventional Cardiology Moderators: Yaron Almagor, Ran Kornowski Discussants: Ronen Jaffe, Eli I. Lev, Eugenia Nikolsky, Amit Segev, Michael Yonash 10:00 am - Case 1: TAVR in a Very Large Aortic Valve Annulus Victor Guetta 10:15 am - Case 2: TAVI for a Failed Bioprosthetic Valve Ariel Finkelstein 10:30 am - Case 3: TAVR in a Patient with Severe CAD Haim Danenberg 10:45 am - Case 4: TAVR in a Patient with Severely Depressed Left Ventricular Ejection Fraction Ariel Roguin The Spectrum of Cardiovascular Intervention Sponsored by the Dutch Working Group of Interventional Cardiology Moderators: Jacques J. Koolen, Jan J. Piek Discussants: Gillian A. Jessurun, T. Oude Ophuis, Martin G. Stoel, Maarten J. Suttorp 11:00 am - Case 1: Thrombectomy in Primary PCI Using a Trevo-Device Robbert J. de Winter 11:15 am - Case 2: A Complication from the Retrograde Approach for CTO Ren J. van der Schaaf 11:30 am - Case 3: An Unusual Cause of LIMA Dysfunction Jeroen Vos 11:45 am - Case 4: Managing a Peripheral Coronary Perforation Koen Teeuwen 12:00 pm - Break Gi2 and SBHCI in Partnership with TCT Session I. New Generation DES and DAPT Controversies Moderators: Alexandre Abizaid, Pedro A. Lemos Discussants: Jamil Abdalla Saad, Rogerio Sarmento-Leite 2:00 pm - Relevant New DES Features to Enhance Safety Alexandre Abizaid 2:10 pm - Will Polymer-Free DES Be Safer Than Bare Metal Stents? Philip M. Urban 2:20 pm - What Evidence Is Necessary to Shorten DAPT After DES? Fausto Feres 2:30 pm - Are Bioabsorbable Vascular Scaffolds Really a Breakthrough? Ron Waksman 2:40 pm - Discussion with Q&A Session II. What New Technologies Will Be Incorporated into My Cath Lab in the Next Five Years? Moderators: Carlos Pedra, Augusto D. Pichard Discussants: Dimytri Siqueira, Marco V. Wainstein 3:00 pm - Futuristic TAVR Devices and Cerebral Protection Eberhard Grube 3:10 pm - Initiating a Renal Denervation Program George D. Dangas 3:20 pm - Promising LAA Closure Devices and the Structural Heart Team Approach Carlos Pedra 3:30 pm - The Future of Interventional Cardiology Is Telemedicine Roberto Botelho 3:40 pm - Discussion with Q&A PCI in 2012 and Beyond Sponsored by Advanced Cardiovascular Solutions Moderators: B.K. Goyal, Susheel Kodali Discussants: Praveer Agarwal, Balram Bhargava, Ali Faizal, P.K. Goel, Girish Kawthekar, Sundeep Mishra, Lekha R.A. Pathak, Gokul M. Reddy 4:00 pm - How I Use Adjunctive Imaging/ Physiology (IVUS, FFR, OCT) to Help Me Do PCI Manish A. Parikh 4:15 pm - Complex Bifurcation PCI Case P.K. Goel 4:25 pm - Discussion 4:30 pm - PCI with an Endovascular Twist! Balram Bhargava 4:40 pm - Discussion 4:45 pm - My Worst (but Salvaged) Complication in the Last Year Ali Faizal 5:00 pm - Adjourn Maintenance of Certification (MOC) Course 8:00 am-2:00 pm Junior Ballroom C This session is only CME accredited. 8:00 am - Welcome and Introduction George D. Dangas 8:05 am - Interventional Cardiology 2012 Update Module Review Moderators: Tayo A. Addo, Emmanouil S. Brilakis Discussants: Nicola Corvaja, Kishore J. Harjai 10:00 am - Break 10:15 am - Interventional Cardiology 2011 Update Module Review Moderators: Duane S. Pinto, Daniel Soffer Discussants: Tayo A. Addo, Emmanouil S. Brilakis 12:00 pm - Interventional Cardiology 2010 Update Module Review Moderators: Charles E. Chambers, Nicola Corvaja Discussants: Tayo A. Addo, Emmanouil S. Brilakis 2:00 pm - Adjourn Special SessionS FDA Town Hall Meeting 8:00 am-5:00 pm Ballroom A This session is only CME accredited. Part I. Cardiovascular Medical Device Innovation: Barriers and Solutions: Session I. The FDA s Safety and Innovation Act: Medical Device User Fees: Implications for New Device Applications Moderators: Tony Blank, Matthew G. Hillebrenner Discussants: Ashley B. Boam, Andrew Farb, Thomas J. Fogarty, Michal Geva, Robert A. Hopkins, Aaron V. Kaplan, Bray Patrick-Lake, Glenn Reicin, Stephen Rowland, Michael Weinstein, Giora Weisz 8:00 am - Opening Remarks Matthew G. Hillebrenner 8:05 am - Impact of FDASIA on Clinical Trials Ashley B. Boam 8:15 am - Large Medical Device Company Perspectives Tony Blank 140

143 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics 8:23 am - A View from a Small Medical Device Company Stephen Rowland 8:31 am - Perspectives from the VC Community Michal Geva 8:39 am - Moderated Discussion with Audience Participation: A View to the Future: New Guidance and Leadership from the FDA Part I. Session II. Cardiovascular Device Innovation: A Blueprint for Solutions Moderators: Ashley B. Boam, Mitchell W. Krucoff Discussants: Kevin Ballinger, Michael Buck, Daniel Canos, Elazer R. Edelman, Andrew Farb, Peter J. Fitzgerald, Louis B. Jacques, Aaron V. Kaplan, John Laschinger, Sonna M. Patel-Raman, Bray Patrick-Lake, Glenn Reicin, Martin T. Rothman, Stanton J. Rowe, Richard S. Stack, Tamara Syrek Jensen 9:10 am - Barriers for Device Development: What s Broke and How to Fix It Aaron V. Kaplan 9:18 am - From Barriers to Solutions: Creating a Sound Ecosystem for Innovation in the United States Mitchell W. Krucoff 9:28 am - FDA s Stimulus Plan: Benefit-Risk Principles, Innovation Initiatives, and Early Feasibility Studies Guidance Andrew Farb 9:38 am - Continuity Equation: Streamlining Processes from Pre-Market Approval to Post-Market Surveillance Roxana Mehran 9:46 am - Global Registry Models to Stimulate International Collaboration and Innovation Daniel Canos 9:54 am - The Reimbursement Factor: Alignment Between Federal Agencies and Societies Tamara Syrek Jensen 10:02 am - Moderated Discussion with Audience Participation: Facilitating Innovation in the United Staets Topic 1: An OPC Model for Standard DES Approval 10:45 am - Justifying an OPC Model for DES Approval: General Principals Laura Mauri 10:53 am - A Clinician s Perspective David E. Kandzari 11:01 am - FDA Perspectives Ashwani Sastry 11:06 am - Moderated Discussion with Audience Participation: OPCs for Standard DES Topic 2: New DES and Expanded Clinical Indications 11:30 am - What s Needed for... Bioabsorbable Polymer Delivery and Bioabsorbable Scaffolds? Ron Waksman 11:37 am - What s Needed for... Label Expansion (Bifurcations, Left Main, AMI, CTO, etc)? Donald Cutlip 11:44 am - FDA Perspectives Ashwani Sastry 11:49 am - Moderated Discussion with Audience Participation: New DES and Expanded Indications Topic 3: Long-term and Short-term DAPT Use After DES 12:15 pm - Completed and Ongoing Clinical Trials Laura Mauri 12:23 pm - Proposals for New Short-term DAPT Use Trials After DES Roxana Mehran 12:31 pm - FDA Perspectives Andrew Farb 12:36 pm - Moderated Discussion with Audience Participation: DAPT Use After DES 1:00 pm - Lunch Break Part II. Interventional Hot Topics: Session IV. Should Novel Therapies Be Reserved Only for Refractory Patients? Moderators: Sonna M. Patel-Raman, Gregg W. Stone Case Example 1: Device Therapies for Mitral Regurgitation Moderators: Sonna M. Patel-Raman, Gregg W. Stone Discussants: Deepak L. Bhatt, Steven F. Bolling, Keith D. Dawkins, Jamey Jacobs, Saibal Kar, John Laschinger, Martin T. Rothman, Joachim Schofer, Charles A. Simonton, Paul A. Sobotka, Niel F. Starksen, Mark A. Turco 1:45 pm - Why Clinical Research in Mitral Valve Disease Has Been Challenging: Rationale for MVARC David H. Adams 1:53 pm - COAPT Trial: Lessons and Perspectives from the Design Phase Gregg W. Stone 2:01 pm - Moderated Discussion with Audience Participation: Devices for Mitral Regurgitation Case Example 2: Renal Denervation for Refractory Hypertension Moderator: Deepak L. Bhatt Discussants: Steven F. Bolling, Steven S. Brooks, Kenneth J. Cavanaugh Jr, Todd D. Courtney, Saibal Kar, Francesco Maisano, Martin T. Rothman, Joachim Schofer, Charles A. Simonton, Paul A. Sobotka, Niel F. Starksen, Mark A. Turco 2:25 pm - Is This the Next Breakthrough Therapy? Technology and Data Overview Joachim Schofer 2:33 pm - SIMPLICITY 3 Update: Issues with Enrolling Refractory Patients Deepak L. Bhatt 2:41 pm - Moderated Discussion with Audience Participation: Renal Denervation for Hypertension Thursday - October 25, 2012 Part I. Session III. New DES and DES New Issues Moderators: Donald Cutlip, Roxana Mehran Discussants: David A. Cox, Keith D. Dawkins, Dennis J. Donohoe, Andrew Farb, Tim A. Fischell, Anthony H. Gershlick, David E. Kandzari, Laura Mauri, Semih Oktay, Stephen Rowland, Sean Salmon, Ashwani Sastry, Charles A. Simonton, Sara Toyloy, Ron Waksman 141

144 Thursday, October 25 Part II. Session V. Managing a Breakthrough New Technology: TAVR Regulatory Conundrums Moderators: Matthew G. Hillebrenner, Martin B. Leon Topic 1: Approval Pathways for Iterative and New TAVR Devices Moderators: Matthew G. Hillebrenner, Martin B. Leon Discussants: Jodi Akin, Charles J. Davidson, Keith D. Dawkins, Jacques Essinger, Peter J. Fitzgerald, Gregory P. Fontana, John Laschinger, Randall T. Lashinski, Frank Litvack, Bernard Lyons, Raj Makkar, Sonna M. Patel-Raman, Nicolo Piazza, Rhonda Robb, Joachim Schofer, E. Murat Tuzcu, Larry L. Wood 3:05 pm - Registry Data Should Be Sufficient to Approve My Next Version TAVR System! Jodi Akin 3:13 pm - Can We be More Creative Than Device vs. Device Trials for New TAVR Systems? Raj Makkar 3:21 pm - Moderated Discussion with Audience Participation: Iterative and New TAVR Devices Topic 2: How to Expand TAVR Clinical Indications Moderators: Matthew G. Hillebrenner, Martin B. Leon Discussants: Jodi Akin, Charles J. Davidson, Keith D. Dawkins, Jacques Essinger, Peter J. Fitzgerald, Gregory P. Fontana, John Laschinger, Randall T. Lashinski, Frank Litvack, Bernard Lyons, Raj Makkar, Sonna M. Patel-Raman, Nicolo Piazza, Rhonda Robb, Joachim Schofer, E. Murat Tuzcu, Larry L. Wood 3:45 pm - The European TAVR Test Track: After Five Years, Have TAVR Use Patterns Drifted out of Control? Nicolo Piazza 3:53 pm - Defending the TVT Registry as a Mechanism to Facilitate Expansion of TAVR Clinical Indications E. Murat Tuzcu 4:01 pm - Moderated Discussion with Audience Participation: TAVR Clinical Indications Topic 3: Accessory TAVR Devices: Clinical Trial Requirements Moderators: Matthew G. Hillebrenner, Martin B. Leon Discussants: Jodi Akin, Charles J. Davidson, Keith D. Dawkins, Jacques Essinger, Peter J. Fitzgerald, Gregory P. Fontana, John Laschinger, Randall T. Lashinski, Frank Litvack, Bernard Lyons, Raj Makkar, Sonna M. Patel-Raman, Nicolo Piazza, Rhonda Robb, Joachim Schofer, Martyn R. Thomas, Sadaf Toor, Hendrik Treede, E. Murat Tuzcu, Larry L. Wood 4:22 pm - Cerebral Embolic Protection During TAVR: Metrics for Evaluating Safety and Efficacy Martyn R. Thomas 4:30 pm - What s the Fuss! Large Hole Vascular Closure Devices (Transfemoral and Transapical) Should Only Require a Simple Safety Registry Peter J. Fitzgerald 4:38 pm - Moderated Discussion with Audience Participation: Accessory TAVR Devices 5:00 pm - Adjourn Morning Spotlight Sessions Alcohol Septal Ablation Symposium 8:00 am-12:00 pm Room A Session I. Hypertrophic Cardiomyopathy (HCM): Diagnosis and Management Moderators: Bernard J. Gersh, Sherif F. Nagueh Discussants: John S. Douglas Jr, Carey D. Kimmelstiel 8:00 am - Epidemiology and Natural History of HCM John S. Douglas Jr 8:15 am - HCM and Sudden Cardiac Death: When to Consider an ICD Bernard J. Gersh 8:30 am - Dynamic Obstruction: Mechanisms and Implications for Treatment Carey D. Kimmelstiel 8:45 am - HCM Management: What Do the Guidelines Say? Bernard J. Gersh 9:05 am - Discussion with Q&A Session II. Alcohol Septal Ablation: Today and Tomorrow Moderators: Michael A. Fifer, Ulrich Sigwart Discussants: Richard G. Bach, Sherif F. Nagueh, Srihari S. Naidu, Christopher D. Nielsen, Rod H. Stables 9:20 am - Historical Perspective on Alcohol Septal Ablation Ulrich Sigwart 9:30 am - Case Selection for Alcohol Septal Ablation Sherif F. Nagueh 9:45 am - Alcohol Septal Ablation: The Procedure Step by Step Christopher D. Nielsen 10:00 am - Complications: How to Avoid, How to Treat Srihari S. Naidu 10:15 am - Inpatient and Outpatient Management After Alcohol Septal Ablation Michael A. Fifer 10:30 am - Long-term Outcomes of Alcohol Septal Ablation Richard G. Bach 10:45 am - The Future? Radiofrequency Catheter Septal Ablation for HCM Rod H. Stables 10:55 am - Discussion with Q&A Session III. Alcohol Septal Ablation: The Great Cases Moderators: Srihari S. Naidu, Ulrich Sigwart Discussants: Valerian Fernandes, Carey D. Kimmelstiel, Rod H. Stables 11:10 am - Great Case 1 Valerian Fernandes 11:20 am - Great Case 2 Carey D. Kimmelstiel 11:30 am - Great Case 3 Rod H. Stables 11:40 am - Roundtable Discussion: Training and Demonstration of Competence, Building a Center of Excellence, and Future Directions 12:00 pm - Adjourn 142

145 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics Aortic Aneurysm Repair and Stent-Graft Devices Sponsored by the International Society of Endovascular Specialists 8:00 am-12:00 pm Room A This session is only CME accredited. Session I. Abdominal (EVAR) Part I Moderators: Jacques Busquet, Christopher K. Zarins Discussants: Frank J. Criado, Barry T. Katzen, Zvonimir Krajcer 8:00 am - The Changing Nature of AAA Disease in the 21st Century Frank J. Criado 8:10 am - The Changing Pattern of AAA Repair in the United States: Is There Still a Role for Elective Open Repair? Zvonimir Krajcer 8:20 am - Review of Current AAA Endografts and Future Devices to Address Unmet Needs Barry T. Katzen 8:30 am - Post-EVAR Follow-up and Imaging Surveillance: Current and Future Trends Robert A. Lookstein 8:40 am - Type II Endoleaks: Implications, Treatment, and Prevention Christopher K. Zarins 8:50 am - Treatment of Type I Endoleaks: Techniques and Results Frank J. Criado 9:00 am - Low-Profile Stent-Graft Delivery Systems Are Coming: What Do They Mean for the Field? Zvonimir Krajcer 9:10 am - Discussion with Q&A 9:55 am - EVAR for Ruptured AAA: Still Controversial? W. Anthony Lee 10:05 am - Discussion with Q&A Session III. Thoracic (TEVAR) Moderators: Frank J. Criado, Wilson Y. Szeto Discussants: Ali Azizzadeh, Edward B. Diethrich, Christoph A. Nienaber, Joseph J. Ricotta II 10:20 am - Thoracic Aortic Repair in the Endovascular Era: Current and Future Perspectives Edward B. Diethrich 10:30 am - Long-Term Outcomes with TEVAR: Impact of Indication and Case Selection Ali Azizzadeh 10:40 am - Forget Treating Chronic Dissections: The Opportunity to Maximize Impact Is in the Acute Phase Christoph A. Nienaber 10:50 am - No Man s Land: Managing Zone 0 and the Aortic Arch Wilson Y. Szeto 11:00 am - Endovascular, Hybrid, and Open Approaches: Decision-making in Paravisceral and Thoracoabdominal Aneurysms Joseph J. Ricotta II 11:10 am - TEVAR-Related Type A Dissection: Causes and Prevention Strategies Wilson Y. Szeto 11:20 am - Traumatic Aortic Injury: Will TEVAR Ever Replace Open Surgery as the Standard of Care? Ali Azizzadeh 11:30 am - Neurological Complications of TEVAR: Prevention and Management Frank J. Criado 11:40 am - Discussion with Q&A 12:00 pm - Adjourn 8:22 am - FAME II: Results and Implications Nico H.J. Pijls 8:34 am - Discussion with Q&A Session II. FFR Case Presentations Moderators: Nils Johnson, Morton J. Kern Discussants: Valerian Fernandes, Robert J. Gil, Allen Jeremias, Habib Samady 8:45 am - Case 1: FFR in Bifurcations Bon-Kwon Koo 8:55 am - Case 2: FFR and Multivessel Disease Pim A.L. Tonino 9:05 am - Case 3: FFR and Left Main Disease Michalis Hamilos 9:15 am - Case 4: FFR in ACS Petr Kala 9:25 am - Case 5: FFR in Tandem Lesions Nico H.J. Pijls Session III. IVUS: The Basics Moderators: Hector M. Garcia-Garcia, Neil J. Weissman Discussants: Yasuhiro Honda, Soo-Jin Kang, Akiko Maehara, Gary S. Mintz, Clemens von Birgelen 9:35 am - Practical Aspects of IVUS: How to Recognize Artifacts and Avoid Mistakes Akiko Maehara 9:45 am - Preintervention IVUS: From Intermediate Lesion Assessment to High-Risk Plaques Clemens von Birgelen 9:57 am - Can IVUS Be Used to Assess Intermediate Lesions? Final FIRST Results Ron Waksman 10:07 am - IVUS-Guided PCI: From Stent Sizing to Predicting Thrombosis and Restenosis Gary S. Mintz 10:19 am - IVUS Assessment of Stent Thrombosis and Restenosis Soo-Jin Kang 10:31 am - Discussion with Q&A Thursday - October 25, 2012 Session II. Abdominal (EVAR) Part II Moderators: Zvonimir Krajcer, Christopher K. Zarins Discussants: Jacques Busquet, Barry T. Katzen, W. Anthony Lee, Robert A. Lookstein 9:25 am - Anatomic Assessment and On-Label vs. Off-Label Device Use: Are There Implications for Long-term Outcomes? Barry T. Katzen 9:35 am - Aortoiliac Aneurysmal Disease: Optimal Repair Techniques Using Available Devices Jacques Busquet 9:45 am - Treatment of Juxtarenal AAA: What Are the Endovascular Options in 2012? W. Anthony Lee Integrating IVUS and FFR into Clinical Practice 8:00 am-12:05 pm Room A Session I. FFR: The Basics Moderators: John McB. Hodgson, Michael J. Lim Discussants: William F. Fearon, Morton J. Kern, Nico H.J. Pijls 8:00 am - What Is FFR, and How Is It Different from Other Indices? William F. Fearon 8:10 am - Practical Aspects of FFR: Tips to Avoid Making Mistakes Morton J. Kern Session IV. IVUS: Case Presentations Moderators: Soo-Jin Kang, Akiko Maehara Discussants: Hector M. Garcia-Garcia, John McB. Hodgson, Gary S. Mintz 10:45 am - IVUS in Acute Coronary Syndromes Jerzy Pregowski 10:55 am - IVUS During CTO Intervention Yasushi Asakura 11:05 am - IVUS and Acute Stent Complications Fernando Alfonso 11:15 am - IVUS and Late Stent Complications Jose de Ribamar Costa Jr 143

146 Thursday, October 25 Session V. Clinical Strategies Moderators: Massoud A. Leesar, Gary S. Mintz Discussant: Kenneth Chin 11:25 am - How I Integrate FFR and IVUS in the Cath Lab and Why Seung-Jung Park 11:35 am - Integrated IVUS and FFR Case 1: A Left Main Intervention Case Presenter: Jose M. de la Torre Hernandez 11:45 am - Integrated IVUS and FFR Case 2: A Non-Left Main Intervention Allen Jeremias 11:55 am - The Final Word: Neither IVUS nor FFR Explain It All Use Common Sense! Jeffrey W. Moses 12:00 pm - Adjourn Primary PCI for STEMI: Drugs, Devices, and Technique Controversies 8:00 am-12:10 pm Room A Session I. Primary PCI in the Era of New Antiplatelet and Anticoagulant Agents Moderators: Cindy L. Grines, Harvey D. White 8:00 am - Debate: Prasugrel or Ticagrelor Should be Used in Nearly All Cases! Dominick J. Angiolillo 8:10 am - Debate: Clopidogrel is Enough and Still Plays a Role for Most! Michael P. Love 8:18 am - Glycoprotein IIb/IIIa Inhibitors in the Era of Bivalirudin and New Oral Antiplatelet Agents: Is Intracoronary Application the Standard of Choice? Rajesh M. Dave 8:26 am - Discussion with Q&A 8:41 am - Debate: Bivalirudin Is the Preferred Anticoagulant Strategy During STEMI! Roxana Mehran 8:49 am - Debate: Enoxaparin or Unfractionated Heparin Plus/Minus Glycoprotein IIb/IIIa Inhibitors Is the Preferred Anticoagulant Strategy During STEMI! Gilles Montalescot 8:57 am - Should Rivaroxaban Be Used in STEMI Patients, and Does Choice of ADP Antagonist (with Rivaroxaban) Matter? C. Michael Gibson 9:07 am - Discussion with Q&A 9:22 am - Debate: Pharmacoinvasive Therapy Is the Method of Choice for Long and Intermediate Transfer Times! Sorin J. Brener 9:30 am - Debate: Primary PCI Is the Default Reperfusion Method Irrespective of Time to Transfer! Cindy L. Grines 9:38 am - Discussion with Q&A Session II. Procedural Management Choices During Primary PCI for STEMI Moderators: Sorin J. Brener, Manel Sabate Discussants: Michael Haude, Harald G.W. Mudra, Graham Nichol, Jennifer A. Tremmel, Marco Valgimigli 9:48 am - Statement: Second Generation DES Are Safer Than BMS and Should Be Used in All Patients Marco Valgimigli 9:58 am - Might a Self-Expanding Stent Have a Role in STEMI? Interim Results from APPOSITION III Harald G.W. Mudra 10:06 am - Should Emergent Catheterization Be Performed in All Patients Resuscitated from Out-of-Hospital Cardiac Arrest? Graham Nichol 10:14 am - Debate: Transradial Access Should Be the Default Access Site in STEMI Patients! Jennifer A. Tremmel 10:22 am - Debate: Transfemoral Access Should Be the Default Access Site in STEMI Patients! Michael Haude 10:30 am - Discussion with Q&A Procedural Management Choices for Infarct Size Reduction Moderators: Anne K. Kaltoft, Holger Thiele 10:45 am - Debate: Yes to Routine Thrombectomy in STEMI: New Trials Are Not Needed! Giuseppe De Luca 10:53 am - Debate: No to Routine Thrombectomy in STEMI: Still Yet to Be Demonstrated! Sanjit S. Jolly 11:01 am - Discussion with Q&A Discussants: Giuseppe De Luca, Sanjit S. Jolly 11:13 am - Should Left Ventricular Mechanical Support Be Used Routinely in Patients with LV Dysfunction and Cardiogenic Shock? Jeffrey J. Popma 11:23 am - Is Intraaortic Balloon Counterpulsation Really Useful in Cardiogenic Shock? Results of the IABP-SHOCK II Trial Holger Thiele 11:33 am - Hypothermia in STEMI: When, to Whom, and How? (Cardiac Arrest, Cardiogenic Shock, Stable STEMI) Michael Mooney 11:48 am - Discussion with Q&A 12:00 pm - Adjourn Edited Taped Case Presentations 9:30 am-5:00 pm Presentation Theater 1 This session is not CME/CNE accredited. Endovascular Interventions Moderators: Richard R. Heuser, David Planer, Mark A. Turco 9:30 am - Peripheral Intervention with Enhanced Efficiency Using Novel, Multifunctional GPSCath Balloon Catheter Gregory Sampognaro 10:00 am - New Technique to Reach Superficial Femoral Artery in Descending Puncture Alejandro Goldsmit 10:30 am - RF Balloon Catheter Renal Denervation Treatment of a Patient with Uncontrolled Hypertension Meital Mazor 11:00 am - Break Nonvalvular Structural Heart Interventions Moderators: Ulf Jens Jensen, Scott Lim, Charanjit S. Rihal 2:00 pm - Alcohol Septal Ablation in HOCM with CT and ICE Guidance Rod H. Stables 2:30 pm - PSOV Closure with MVSD Occluder Giuseppe Gioia 3:00 pm - IVUS-Guided Percutaneous Paravalvular Leakage Closure Peter den Heijer 3:30 pm - Break Coronary Interventions Moderators: Maurice Buchbinder, J. Aaron Grantham, Satoru Sumitsuji 4:00 pm - Subintimal Transcatheter Withdrawal (STRAW) of Hematoma Compressing the Distal True Lumen: A Novel Technique to Facilitate Distal Reentry During Recanalization of Chronic Total Occlusions Elliot Smith 4:30 pm - Orbital Atherectomy Jeffrey Chambers 5:00 pm - Adjourn 144

147 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics Challenging Case Video Presentations Session IV. Coronary and Endovascular 10:00 am-11:00 am Hall D This session is not CME/CNE accredited. TCT Unexpected Occlusion, Unexpected Recanalization Evgeniy Merkulov et al TCT Floating Coronary Stent M.reza Habibzadeh et al TCT Retrograde Recanlize LM Ostium CTO Without Stump in a Twice CABG Patient Hsiu-yu Fang et al TCT A Successful Case with Severe Calcified Chronic Total Occlusion Without Stamp Using Retrograde Approach Yuji Sakanoue et al TCT Catheter-Directed Thrombolysis for Subacute Stent Thrombosis After Failure of Conventional Treatment Strategies Jon George et al TCT A Novel Percutaneous Implant for the Treatment of Resistant Hypertension Benjamin Scott et al TCT Excimer Laser Ablation for Intracoronary Organic Huge Thrombus in a Case of Recent Myocardial Infarction: Angioscopic Evidence of Effectiveness Masak Awata et al TCT Percutaneus Coronary Intervention in Chronic Total Occlusion: Finding Micro Channel and Crushing the Rock Sodiqur Rifqi et al TCT Acute Coronary Syndrome in Patient with Severe Pulmonary Hypertension and Left Main Coronary Artery Compression: Role of Intravascular Ultrasound in Diagnosis and Optimization of PCI Arkadiusz Pietrasik et al TCT A Case of Sheathless Transradial Coronary Intervention for Complex Coronary Lesions Using a Standard Guiding Catheter Jaehuk Choi et al TCT Bridging a Long Coronary Aneurysm with Overlapping Stentgrafts Inside a Long Length Drug-Eluting Stent as Scaffold in Acute MI Case Srikant Shetty et al TCT Severe Longitudinal Stent Deformation David Roy et al TCT Transradial PCI-Successful Stent Retrieval Surya Prakasa Rao Vithala et al TCT Left Atrial Inflow and Outflow Obstruction from Epicardial Hematoma Complicating a Retrograde Approach Joji Varghese et al TCT Left Main Bifurcation Stenting with Mini Crush Viveka Kumar et al TCT Entrappment of Side Branch Guide Wire Vikrant Vijan et al TCT Myocardial Infarction with Persistent Shock Due to Right Heart Failure Despite Percutaneous Left Ventricular Support Patrick Hunziker et al TCT Three-Year Follow-up After PCI of a 54-Year-Old Patient with Three-Vessel Disease Including Two Chronic Total Occlusions by Optical Coherence Tomography Martin Bergmann et al TCT Optical Coherence Tomography (OCT) Helping with Culprit Lesion Identification Ashish Shah et al TCT A Case of Successful Bailing Out from Coronary Perforation Complicated with PCI for RCA-CTO Hiroyuki Kunii et al TCT Use of Chimney Stent in the Left Subclavian Artery for Blunt Thoracic Aortic Injury Won Ho Kim et al TCT Optimal Treatment of Massive Bilateral Deep Venous Thrombosis of Lower Extremities, Iliac Veins, and IVC Filter Mohsen Sharifi et al TCT Multilevel Endovascular Access Successful Treat Long Total Occlusion: From Iliac Ostium to Distal Femopopliteal Artery Tien-yu Wu et al TCT Unusual Case of Spontaneous Thrombosis of Lower Abdominal Aorta in a Patient with Idiopathic Thrombocytopenic Purpura: Successful Endovascular Treatment Abdul Basit et al TCT Less Than Common: Retrograde Popliteal to Common Femoral Revascularization Eric Fuh et al TCT Brachio-Femoral Parallel Wiring After Abdominal Aortic Dissection in an Aortoiliac Bifurcating Osteal Stenosis Treated with Final Kissing Stenting Nanda Panigrahi et al TCT Ipsilateral 300 cm Wire Externalization Technique in the Infrapopliteal CTO Lesion (Transplantar Loop) Tien-yu Wu et al TCT Left Subclavian Intervention Complicated by Acute Anterior Wall Myocardial Infarction Kintur Sanghvi et al TCT Middle Aortic Syndrome with Renal Involvement an uncommon Presentation of Takayasu Arteritis Treated with Stenting Madahavpeddi Aditya et al TCT Endovascular Management of Chronic Iliac Vein Occlusion in May-Thurner Syndrome Jon George et al TCT A Technically Challenging Case of Renal Artery Bifurcation Stenting Requiring Dual Access (Brachial and Femoral) Approach Rajiv Ananthakrishna et al TCT Successful True Lumen Restenting Through Folse Lumen Stent Strut for In-Stent Occlusion in the Superficial Femoral Artery Yoshimitsu Soga et al TCT Celiac Artery and Superior Mesenteric Artery Angioplasty in a Young Female Deepak Davidson et al TCT Endovascular Treatment in Challenging Case of Charcot Ischemic and Infected Foot Luis Palena et al TCT Four Cases to Revascularize Difficult and Long 20 cm BTK CTO Lesions by the SSD (Super Speed Drilling) Technique Shinichiro Sakota et al TCT Concurrent Endovascular Repair of Extensive Thoracic Aortic and Infrarenal Aorto-Iliac Aneurysms Ezhilan Janakiraman et al TCT Successful Angioplasty with Retrograde Direct Superficial Femoral Artery Puncture After Failed Bidirectional Approach in Chronic Femoral Artery Occlusion Taku Iwaki et al TCT IVUS-Assisted Recanalization of Long SFA Total Occlusion from Its Ostium Jae-hwan Lee et al TCT Static Contrast Technique for Creating Transpedal Arterial Access in Patients with Tibioperoneal Occlusions John Chien-hwa Chang et al Thursday - October 25,

148 Thursday, October 25 TCT Endovascular Management of Total Aortic Occlusion in Hypoplastic Aortic Syndrome Hossam Mansour et al TCT Subintimal Angioplasty for Severe Calcified Total Occlusion of Iliac Artery with Confluent Two-Balloon Technique After PTA Failure with Outback Reentry Device Woong Chol Kang et al TCT Intramural Hematoma William Mcmillan et al TCT A Case of Successful Penetration of Superficial Femoral Artery Chronic Total Occlusion Lesion with Bidirectional Approach via Bridging Collateral Branch Saving the Collateral Branch from Deep Femoral Artery Nobuhiro Hara et al TCT Intrahepatic Budd Chiari Syndrome: Transhepatic Percutaneous Stenting of Right Hepatic Vein Raja Mantri et al TCT Subintimal Antegrade Stenting (Reverse Stent CART Technique) to Facilitate Retrograde Wire Reentry in Successful Treatment of BT? Occlusion with CLI Valeri Gelev et al TCT Percutaneous Stenting for IVC Obstructioon Raja Mantri et al TCT A Neocarena Reconstruction Technique: A New Practice Tool to Manage Side Branch Occlusion After Covered Stent Implantation in Vascular Injuries Chiara Bernelli et al TCT Using Amplatzer Plug for Neck Remodeling in Challenging Endovascular Aortic Repair for Contained Rupture Abdominal Aortic Aneurysm Roberto Gandini et al TCT Successful Stenting of Anastomotic Stenosis of the Left Pulmonary Artery After Bilateral Lung Transplantation Thomas Konorza et al TCT Unique Application of Percutaneous Mitral Valvotomy Balloon for Post Liver Transplant Inferior Vena Cava Occlusion Vipil Roy et al TCT Coeliac and Mesenteric Artery Occlusion: Newer Endovascular Approach to Vascular Emergency Ashraf Manzil et al TCT Endovascular Repair of Giant Ruptured Aneurysm of Coeliac/ Hepatic Artery Harinder Bali et al TCT Endovascular treatment of an Abdominal Aortic Stenosis After AAA Surgery Felix Damas De Los Santos et al TCT Percutaneous Repair of a Large Sacular Infra-Renal Abdominal Aortic Aneurysm by Making Aorto Uni-Iliac Device on the Table Using Atrium Stents and Vascular Plug Narendra Khanna et al Presentation Theater 12:15 pm-1:15 pm Please see page 175 for the Breakfast Meeting schedule. Lunchtime Sessions Hot Topics ACC Special Fellows Session II. Oral Anticoagulation 2012 for VTE, Atrial Fibrillation, and Valvular Heart Disease 12:15 pm-1:45 pm Room D This session is only CME accredited. Moderators: C. Michael Gibson, Jonathan L. Halperin 12:15 pm - Novel Anticoagulants for Stroke Prevention in Patients with Atrial Fibrillation Jonathan L. Halperin 12:50 pm - Novel Anticoagulants in Patients with Acute Coronary Syndromes C. Michael Gibson 1:25 pm - Discussion with Q&A 1:45 pm - Adjourn Cath Lab Directors Lunch: Managing the Present, Preparing for the Future 12:15 pm-1:45 pm Room C This session is only CME accredited. 12:15 pm - Introductory Remarks Kishore J. Harjai Session I. Appropriateness and Advocacy Moderator: Jeffrey W. Moses Discussants: Steven R. Bailey, Kishore J. Harjai 12:18 pm - Are Appropriate Use Criteria Ready for Clinical Practice? Cath Lab Director s View Kishore J. Harjai 12:26 pm - The Misrepresentation of Interventional Cardiology in the Lay Media Jeffrey W. Moses 12:33 pm - Advocacy for Interventional Cardiology: Time for a Wake-up Call Steven R. Bailey 12:40 pm - Discussion with Q&A Session II. Focus on the Young Interventionalist Moderator: David J. Cohen Discussants: Tony Das, Brij Maini 12:45 pm - Navigating Local Politics: A Career Guide for Young Interventionalists Brij Maini 12:54 pm - Managing Your Reputation as an Interventional Cardiologist Brij Maini 1:02 pm - A Stepwise Approach to Building a Career in Interventional Cardiology Research David J. Cohen 1:10 pm - Discussion with Q&A Session III. Innovation, Invention, and Research Moderator: Neal L. Eigler Discussants: Adnan Kastrati, Giora Weisz 1:15 pm - The Dos and Don ts of Initiating Prospective Randomized Clinical Trials Adnan Kastrati 1:23 pm - The Future Cath Lab: Focus on Innovation, Interspecialty Collaboration, and Lifelong Learning Giora Weisz 1:31 pm - The Interventionalist as Inventor/ Entrepreneur: A Personal Journey Neal L. Eigler 1:39 pm - Discussion with Q&A 1:40 pm - Closing Remarks Kishore J. Harjai 1:45 pm - Adjourn CT Planning for Transcatheter Aortic Valve Replacement 12:15 pm-1:45 pm Room D This session is only CME accredited. Moderator: James K. Min Discussants: Gudrun Feuchtner, Jonathon A. Leipsic, Robert J. Siegel, David A. Wood 12:15 pm - CT for Aortoiliofemoral and Aortic Valve Assessment Gudrun Feuchtner 12:30 pm - Discussion with Q&A 12:33 pm - CT for Aortic Annulus Sizing and Angle Prediction of TAVR Deployment Jonathon A. Leipsic 12:48 pm - Discussion with Q&A 146

149 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics 12:51 pm - CT for Preventing and Predicting TAVR-Associated Complications James K. Min 1:06 pm - Discussion with Q&A 1:09 pm - Reconciling Discordance Between Echo and CT in TAVR Robert J. Siegel 1:24 pm - Discussion with Q&A 1:27 pm - Imaging for TAVR: An Interventionalist s Perspective David A. Wood 1:42 pm - Discussion with Q&A 1:45 pm - Adjourn Disparities in Interventional Cardiology: Taking a Broader View 12:15 pm-1:45 pm Room D Moderators: Yele Aluko, A.J. Conrad Smith Discussants: Alexandre Abizaid, Christian W. Hamm, Manesh R. Patel, Christopher J. White 12:15 pm - Geographic Disparities in the Management of ACS in the United States: Making the Case for Standardization of Care Yele Aluko 12:25 pm - Variations in the Management of ACS in South America: A Viewpoint from South of the Border Alexandre Abizaid 12:35 pm - Variations in Management of ACS in Europe: Implications for Health Care Reform in the United States Christian W. Hamm 12:45 pm - Discussion with Q&A 1:00 pm - Racial Disparities in Interventional Cardiology in the United States: Behavior, Biology, or Bias? A.J. Conrad Smith 1:10 pm - Discussion with Q&A Point Counterpoint: Appropriate Use Criteria: In Search of Institutional and Individual Accountability 1:15 pm - Pro: Tracking and Aiming for Appropriate Use Criteria Goals Will Optimize Physician Performance and Patient Outcomes! Manesh R. Patel 1:25 pm - Con: A Strict Reliance on Appropriate Use Criteria Is Misguided Policy! Christopher J. White 1:35 pm - Discussion and Closing Comments 1:45 pm - Adjourn Extended Results from Important Drug-Eluting Stent Trials 12:15 pm-2:00 pm Room D Moderators: Joost Daemen, Stephen G. Worthley Discussants: James C. Blankenship, Robbert J. de Winter, Daljeet S. Gambhir, Antoine Lafont, Erick Schampaert, Bonnie H. Weiner 12:15 pm - EXAMINATION Two-Year: A Prospective, Randomized Trial of Everolimus-Eluting vs. Bare Metal Stents in Patients with ST-Segment Elevation Myocardial Infarction Manel Sabate 12:25 pm - Discussion 12:30 pm - RESET Two-Year: A Prospective, Randomized Trial of Everolimus-Eluting vs. Sirolimus-Eluting Stents Ken Kozuma 12:40 pm - Discussion 12:45 pm - TWENTE Two-Year: A Prospective, Randomized Trial of Everolimus-Eluting vs. Zotarolimus-Eluting Stents Clemens von Birgelen 12:55 pm - Discussion 1:00 pm - SORT OUT IV Three-Year: A Prospective, Randomized Trial of Everolimus-Eluting vs. Sirolimus-Eluting Stents Lisette Okkels Jensen 1:10 pm - Discussion 1:15 pm - LEADERS Five-Year: A Prospective, Randomized Trial of Bioabsorbable Polymer-based Biolimus-Eluting vs. Sirolimus-Eluting Stents Patrick W. Serruys 1:25 pm - Discussion 1:30 pm - SYNTAX SCORE II: An Improved Risk Score Based on Clinical and Angiographic Variables Vasim Farooq 1:40 pm - Discussion 1:45 pm - Long-Term Results of Bifurcation Stenting with Everolimus- Eluting vs. Sirolimus-Eluting Stents: The SEA-CORP BC Trials Francesco Burzotta 1:55 pm - Discussion 2:00 pm - Adjourn Interventional Cardiology, Cardiovascular Genetics, and the Era of Personalized Medicine 12:15 pm-1:45 pm Room D Moderators: Christopher B. Granger, W. Craig Hooper, H. Robert Superko Discussant: Paddy Barrett 12:15 pm - 2C19 and Warfarin: Clinical Utility or Do New Medications Make It Obsolete? Christopher B. Granger 12:35 pm - Case Study Christopher B. Granger, W. Craig Hooper, H. Robert Superko 12:45 pm - Genetic Testing for 9p21: The Case for Health Care Insurance Reimbursement H. Robert Superko 1:05 pm - Case Study Christopher B. Granger, W. Craig Hooper, H. Robert Superko 1:15 pm - 4q25 and Prediction of Atrial Fibrillation: How Can This Information Help the Clinician? Paddy Barrett 1:35 pm - Case Study Christopher B. Granger, W. Craig Hooper, H. Robert Superko 1:45 pm - Adjourn Minimizing and Managing Cath Lab Complications 12:15 pm-1:45 pm Room C This session is only CME accredited. Moderators: Cindy L. Grines, Thomas D. Stuckey Discussants: Fernando Alfonso, Stephen Balter, Ronald Caputo, Charles E. Chambers, Anne K. Kaltoft, Roger J. Laham, Greg Mishkel, Massimo Napodano, Theodore L. Schreiber, Molly Szerlip, Mark W. I. Webster Management of Large Thrombus Burden (and Embolization) 12:15 pm - Topic Essentials Anne K. Kaltoft 12:20 pm - Case Presentation with Discussion Thomas D. Stuckey Use of Impella for High-Risk PCI 12:30 pm - Topic Essentials Theodore L. Schreiber 12:35 pm - Case Presentation with Discussion Molly Szerlip Thursday - October 25, 2012 Spontaneous Coronary Dissection 12:45 pm - Topic Essentials Greg Mishkel 147

150 Thursday, October 25 12:50 pm - Case Presentation with Discussion Fernando Alfonso Radiation Management in Complex Coronary Interventions 1:00 pm - Topic Essentials Stephen Balter 1:05 pm - Case Presentation with Discussion Mark W.I. Webster Challenges in Guiding Catheter Support and Stent Delivery 1:15 pm - Topic Essentials Clemens von Birgelen 1:20 pm - Case Presentation with Discussion Ronald Caputo Longitudinal Stent Deformation 1:30 pm - Topic Essentials John A. Ormiston 1:35 pm - Case Presentation with Discussion Thomas D. Stuckey 1:45 pm - Adjourn Optimizing Care for Women with Cardiovascular Disease 12:15 pm-1:45 pm Room C This session is only CME accredited. Moderators: Alexandra J. Lansky, Anna Sonia Petronio, Jennifer A. Tremmel Discussant: Eugenia Nikolsky 12:15 pm - Introduction and Session Goals Alexandra J. Lansky 12:20 pm - Gender Variation in Plaque Characteristics and Vulnerability: Lessons from PROSPECT Akiko Maehara 12:30 pm - Discussion with Q&A 12:35 pm - Diagnostic Considerations in Women with Intermediate Coronary Lesions: Insights from FAME Jennifer A. Tremmel 12:45 pm - Discussion with Q&A 12:50 pm - Gene Expression in the Diagnosis of Coronary Artery Disease: Is There a Role in Women? John A. McPherson 1:00 pm - Discussion with Q&A 1:05 pm - TAVR Outcomes in Women: The European Experience Anna Sonia Petronio 1:15 pm - Discussion with Q&A 1:20 pm - Bleeding Complications in Women Undergoing Revascularization: Implications for Adjunctive Pharmacology and Prevention Eugenia Nikolsky 1:30 pm - Discussion with Q&A 1:35 pm - Case Presentation: Spontaneous Coronary Disection, an Under-Recognized Cause of ACS in Women Greg Mishkel 1:45 pm - Adjourn Special JACC Session: How to Write and Evaluate Medical Journal Articles 12:15 pm-1:45 pm Room C This session is only CME accredited. Moderators: Anthony N. DeMaria, Spencer B. King III, Jagat Narula 12:15 pm - How to Write Publishable Papers (with Examples of Dos and Don ts Anthony N. DeMaria 12:30 pm - Discussion with Q&A 12:45 pm - How to Revise Your Manuscript Jagat Narula 1:00 pm - Discussion with Q&A 1:15 pm - Evaluating a Research Paper: What Constitutes a Good Review Spencer B. King III 1:30 pm - Discussion with Q&A 1:45 pm - Adjourn Learn the Technique These sessions are only CME accredited. Complex Bifurcation Lesions 12:15 pm-1:45 pm Room B211 Moderators: Thierry Lefevre, Issam D. Moussa, David G. Rizik Discussants: Francesco Burzotta, Alaide Chieffo, Evald H. Christiansen 12:15 pm - Introduction Issam D. Moussa 12:18 pm - When Is a Two-Stent Technique Needed? Alaide Chieffo 12:28 pm - Case 1: A Complex Bifurcation with One Stent Thierry Lefevre 12:38 pm - Discussion 12:43 pm - Case 2: A Complex Bifurcation with Two Stents (T-Stenting) David G. Rizik 12:53 pm - Discussion 12:58 pm - Case 3: A Complex Bifurcation with Two or More Stents (Culotte Stenting) John A. Ormiston 1:08 pm - Discussion 1:13 pm - How to Solve Difficult Side Branch Access Issues Francesco Burzotta 1:23 pm - Case 4: Difficult Side Branch Access Evald H. Christiansen 1:33 pm - Discussion 1:38 pm - Conclusions David G. Rizik 1:45 pm - Adjourn Nuts and Bolts of FFR 12:15 pm-1:45 pm Room B212 This session is only CME accredited. Session I. The Basics Moderators: William F. Fearon, Bon-Kwon Koo 12:15 pm - Coronary Physiology and FFR William F. Fearon 12:25 pm - Can Any IVUS/OCT Parameters Replace FFR? Bon-Kwon Koo Session II. The Cases Moderators: William F. Fearon, Bon-Kwon Koo 12:30 pm - Cases 1 and 2: FFR in Acute Coronary Syndromes Habib Samady 12:45 pm - Cases 3 and 4: FFR in Multiple and Serial Stenoses Pim A.L. Tonino 1:00 pm - Cases 5 and 6: FFR in Left Main Disease: From Simple Ostial to Complex Soo-Jin Kang 1:15 pm - Cases 7 and 8: FFR in Non-Left Main Bifurcation Lesions Nick Curzen 1:30 pm - Cases 9 and 10: FFR Cases with Possible Pitfalls Peter C. Smits 1:45 pm - Adjourn Paravalvular Leak Closure 12:15 pm-1:45 pm Room A208 Moderators: Eulogio J. Garcia, Charanjit S. Rihal Discussants: Miguel A. Garcia-Fernandez, Vuyisile T. Nkomo, Carlos E. Ruiz 12:15 pm - Echocardiographic Diagnosis and Guidance of Aortic Paravalvular Leak Closure Vuyisile T. Nkomo 12:25 pm - Tips and Tricks for Percutaneous Closure of Aortic Paravalvular Leaks Charanjit S. Rihal 148

151 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics 12:35 pm - Percutaneous Closure of an Aortic Paravalvular Leak: Step by Step Case Eulogio J. Garcia 12:45 pm - Echocardiographic Diagnosis and Guidance of Mitral Paravalvular Leak Closure Miguel A. Garcia-Fernandez 12:55 pm - Other Imaging Techniques for Paravalvular Leaks Carlos E. Ruiz 1:05 pm - Step-by-Step Case: Percutaneous Closure of Mitral Paravalvular Leak: Anterograde Approach Charanjit S. Rihal 1:15 pm - Step-by-Step Case: Percutaneous Closure of Mitral Paravalvular Leak: Retrograde Approach Eulogio J. Garcia 1:25 pm - Step-by-Step Case: Closure of Mitral Paravalvular Leak: Transapical Approach Carlos E. Ruiz 1:35 pm - Discussion with Q&A 1:45 pm - Adjourn Percutaneous Edge-to-Edge Mitral Valve Repair: Tips and Tricks 12:15 pm-1:45 pm Room A209 Moderators: Karl-Heinz Kuck, Scott Lim 12:15 pm - Patient Selection for MitraClip Procedures Gorav Ailawadi 12:30 pm - Imaging: 2-D and 3-D TEE by and for the Interventionalist Scott Lim 12:45 pm - Case Review 1: How to Do the Transseptal for MitraClip Richard Smalling 1:00 pm - Case Review 2: How to Do Multiple Clip Implants for Functional MR Huseyin Ince 1:15 pm - Case Review 3: How to Decide About a Second Clip for DMR Richard Smalling 1:30 pm - Case Review 4: How to Deal with Valve Complications Karl-Heinz Kuck 1:45 pm - Adjourn The Retrograde Approach to CTOs Presented in Association with Complex Cardiovascular Therapeutics 12:15 pm-1:45 pm Room B213 Moderators: Osamu Katoh, Etsuo Tsuchikane 12:15 pm - Collateral Channel Navigation: What s the Key of Success? Osamu Katoh 12:25 pm - Crossing CTO Lesions: How to Ensure and Facilitate Masahisa Yamane 12:35 pm - Case 1: My Own Complex Retrograde Approach J. Aaron Grantham 12:50 pm - Case 2: My Own Complex Retrograde Approach Craig A. Thompson 1:05 pm - Case 3: My Own Complex Retrograde Approach Etsuo Tsuchikane 1:20 pm - Case 4: My Own Complex Retrograde Approach R. Michael Wyman 1:35 pm - Discussion with Q&A 1:45 pm - Adjourn Transradial Intervention 12:15 pm-1:45 pm Room B210 Moderators: Philippe Généreux, Sanjit S. Jolly, Margaret B. McEntegart Discussants: Olivier F. Bertrand, James Nolan, Samir B. Pancholy 12:15 pm - The Basics of Transradial Access Olivier F. Bertrand 12:27 pm - Discussion 12:30 pm - Complications of Transradial Access Philippe Généreux 12:42 pm - Discussion 12:45 pm - Radial Sheath Removal and Prevention of Radial Occlusion Samir B. Pancholy 12:57 pm - Discussion 1:00 pm - Radial Angiography and PCI in Patients with Prior CABG Margaret B. McEntegart 1:12 pm - Discussion 1:15 pm - Radial Access and Primary PCI in STEMI Sanjit S. Jolly 1:27 pm - Discussion 1:30 pm - The Radial Learning Curve James Nolan 1:40 pm - Wrap-up and Final Comments 1:45 pm - Adjourn Challenging Case Video Presentations Session V. Imaging and Physiologic Lesion Assessment and Structural 2:00 pm-3:00 pm Hall D This session is not CME/CNE accredited. TCT Follow-up of Spontaneous Coronary Artery Dissection: Detection of Intramural Hematoma and Serial Findings of Non-Contrast T1-Weighted Magnetic Resonance Imaging Takahiro Nakashima et al TCT A Case of Stent Ablation in Left Anterior Descending Coronary Artery Observed by Optical Coherence Tomography Yuzo Kagawa et al TCT Longitudinal Stent Elongation Kensuke Matsushita et al TCT Can 64-Slice Computed Tomography Coronary Angiography Help You Assess Caliber and Length of the Stent in a Long Small Distal Subtotal Occlusion in 36-Year-Old Male with CABG? Hesham Naiem et al TCT Instantaneous wave-free ratio (ifr) to guide coronary revascularisation following acute severe reaction to intravenous adenosine Sukhjinder Nijjer et al TCT The First Clinical Application of the Instantaneous Wave-Free Ratio (ifr) to Guide Coronary Intervention Sukhjinder Nijjer et al TCT A Filling Defect in the Coronary Artery Accompanied by ST-Segment Elevation Is Not Always a Thrombus Ioannis Iakovou et al TCT Multiple Stent Fractures After Retrograde Chronic Total Occlusion Percutaneous Intervention Felipe Hernandez et al TCT Optical Coherence Tomographic Findings of In-Stent Neoatherosclerosis After Xience V Stent Implantation Setsuo Kumazaki et al TCT Rescue Management of Spontaneous Coronary Artery Dissection Guided by Optical Coherence Tomography (OCT) Nicolas Combaret et al Thursday - October 25,

152 Thursday, October 25 TCT Multiple Recanalized Images of Thrombotic Occlusion after Coronary Artery Dissection Insights from Optical Coherence Tomography Hiroaki Takashima et al TCT A Case of Very Late Stent Thrombosis: Five Years After Sirolimus- Eluting Stent Implantation Observed by OCT and Angioscope Takayuki Ishihara et al TCT Is It a Really Easy Case? Only IVUS Tells the Truth Seiko Ide et al TCT Fractional Flow Reserve Can Predict an Unusual Complication During Percutaneous Coronary Intervention Which Was Difficult to Recognize with Other Modalities Hideto Yano et al TCT Hemodynamic Significance of Coronary Cameral Fistula Assessed by Fractional Flow Reserve Jun-hyok Oh et al TCT Stent Thrombosis: The Value of OCT to Elaborate the Mechanism Richard Anderson et al TCT Slow Flow and Neoatherosclerosis in a Patient with Very Late Instent Restenosis After Sirolimus-Eluting Stent Implantation: Insight from Optical Coherence Tomography Analysis Kenji Sakata et al TCT Yellow Means Trouble David Erlinge et al TCT Mulimodality Imaging Reveals Necessity of Embolization Protection Devices During Intervention of Vulnerable Plaque in Native Coronary Arteries Heike Hildebrandt et al TCT Double Device Failure During TAVI Pawel Kleczynski et al TCT Direct Aortic Transcatheter Aortic Valve Implantation in a Patient with Porcelain Aorta Giuseppe Bruschi et al TCT Percutaneous Closure of Acquired Gerbode-Type Membranous Septum Defect Grzegorz Smolka et al TCT Late Embolization of a Vascular Plug III Device After Mitral Paravalvular Leak Closure Dabit Arzamendi et al TCT Late Complication After Percutaneous ASD Closure Pawel Kleczynski et al TCT Successful Treatment by Transcatheter Aortic Valve Implantation of Severe Aortic Regurgitation in Patient with Ascending Aorta Prosthesis Marco Luciano Rossi et al TCT Retrograde Percutaneous Closure of a Ventricular Septal Defect After Myectomy for Hypertrophic Obstructive Cardiomyopathy Apurva Badheka et al TCT Simultaneous Antegrade and Retrograde Approach During PTMC in a Case of Severe Rheumatic Mitral Stenosis with Significant Submitral Fusion Dattatreya Rao et al TCT Percutaneous Closure of a Left Ventricular Pseudoaneurysm After Sapien XT Transapical Transcatheter Aortic Valve Replacement Anna Bortnick et al TCT Simultaneous Stenting of Systemic and Pulmonary Venous Baffle Obstruction After a Mustard Procedure Dhaval Parekh et al TCT Plugging the Hole: Successful Percutaneous VSD Closure and Initiation of Veno-Arterial Extracorporeal Membrane Oxygenation as a Bridge to Recovery Maya Kommineni et al TCT A Challenging Left Atrial Appendage Closure Pedro Carrilho-ferreira et al TCT Strut Fractures of CoreValve Frames Chen Mao et al TCT Use of 3-D MRA Overlay to Guide Transcatheter Pulmonary Valve Replacement in an Adult with Tetralogy of Fallot Jamil Aboulhosn et al TCT Trancatheter Treatment of Lutembacher Syndrome: A Case Report Suresh Patted et al TCT Catastrophic Simultaneous Severe Aortic and Mitral Regurgitation Due to a Low CoreValve Implantation Resolved with a Valve-in-Valve Maneuver Yigal Piña-reyna et al TCT Complex Percutaneous Repair of Ascending to Descending Aorta Graft and Descending Aortic Pseudoaneurysm in a Patient with Congenital Interrupted Aorta and Recurrent Obstruction Dominik Wiktor et al TCT Partial Closure of Largest (Ever Made) Secundum Atrial Septal Defect Using a Fenestrated Occlutech Figulla Flex II ASD 48-mm Device in a Patient with Near Systemic Pulmonary Artery Pressure: Case Report Eustaquio Maria Onorato et al TCT Ventricular Septum Defect and Complete AV Block After TAVI Marco Agrusta et al TCT Successful Percutaneous Double Valve Treatment for Severe Mitral Regurgitation and Severe Aortic Stenosis with MitraClip Followed by Transcutaneous Aortic Valve Replacement (TAVR) with a Edwards Sapien Valve in an Extreme Risk Surgical Patient Gian-carlo Giove et al TCT Percutaneous Brock Procedure Balram Bhargava et al TCT Combined Percutaneous Balloon Mitral Valvuloplasty and Left Atrial Appendage Occlusion Device Implantation for Rheumatic Mitral Stenosis and Atrial Fibrillation Dale Murdoch et al TCT Hybrid Transapical Device Closure of Left Ventricular Pseudoaneurysm Under Transoesophageal Echocardiographic Guidance Vijayakumar Subban et al TCT Rise of the Machines: Cutting-Edge Interventional Heart Failure Therapies for Patients on the Brink Christian Nagy et al TCT Closure of an ASD in a Patient with Pulmonary Hypertension Geoffrey Crimmins et al TCT Snaring a Embolized Coil at Intracerebral Artery During Coronary Artery Fistula Embolization Hsiu-yu Fang et al TCT Transcatheter Mitral Valve Repair Early After Primary Percutaneous Coronary Angioplasty of Left Main Claudia Fiorina et al TCT Transcatheter Closure of a Large Postinfarction Ventricular Septum Defect with an Amplatzer Septal Occluder Grzegorz Smolka et al TCT Transfemoral TAVI Complicated by Left Main Occlusion Fadi Al-rashid et al TCT Transcatheter Aortic Valve Implantation in a 26-Year-Old Nonoperable Patient with Aortic Stenosis Ricardo Sanz-ruiz et al 150

153 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics TCT Balloon Jailed in to the CoreValve Frame Maciej Dabrowski et al TCT Apical Hypertrophic Cardiomyopathy: A Preliminary Attempt at Palliation Using Subselective Alcohol Ablation Jorge Escobar et al TCT Closure of Psuedoaneurysm of the Ascending Aorta via a Percutaneous Left Ventricular Apical Approach James Slater et al TCT Is It Safe to Stretch a SAPIEN Valve? A Case of Successful Valve-in-Valve TAVR to Correct Severe Paravalvular Leak in a Patient with Undersized Aortic Valve Mihir Kanitkar et al Afternoon Spotlight Sessions Drug-Coated Balloons (DCB): Clinical Data and Applications 2:00 pm-5:56 pm Room A This session is only CME accredited. Session I. Paclitaxel-Coated Balloon Technology Moderators: Juan F. Granada, Bruno Scheller 2:00 pm - Impact of Paclitaxel Formulation on Drug Transfer, Tissue Pharmacokinetics, and Biological Activity Juan F. Granada 2:10 pm - Paclitaxel Delivery and Tissue Effects: Similarities and Critical Differences with DES Renu Virmani Session II. Coronary DCB Program Update Moderators: Detlef G. Mathey, Pieter R. Stella 2:20 pm - The Big Picture: Potential Role of DCB in a Mature Coronary DES Market (SeQuent Please Worldwide Registry) Jochen Wöhrle 2:30 pm - Coronary ISR: An Accepted Clinical Indication in the DES World? Huay Cheem Tan 2:40 pm - The PEPCAD Coronary Program: Iopromide-Based PCB Coating (B. Braun Medical) Bruno Scheller 2:50 pm - SEDUCE: A Prospective, Randomized Trial of Drug Coated Balloon vs. Everolimus-Eluting Stent in for BMS Restenosis: Optical Coherence Tomography Assessment Tom Adriaenssens 2:58 pm - DES-Type Results with a DCB Plus BMS in Native Coronary Arteries? INDICOR Results (B. Braun Medical) Upendra Kaul 3:06 pm - From IMPACT-ISR to BELLO: Urea-Based PCB Coating (Invatec) Antonio Colombo 3:16 pm - The VALENTINE Trials: Shellac-Based PCB Coating (Eurocor) Giuseppe M. Sangiorgi 3:26 pm - From PEPPER to DELUX Registry: BTHC-Based PCB Coating (BIOTRONIK) Christoph K. Naber 3:36 pm - First-in-Man Results with a Novel Nanoparticle-Based Sirolimus-Coated Balloon in Coronary In-Stent Restenosis Lesions (Concept Medical) Suhas S. Lele 3:44 pm - Development of a Drug-Coated Scoring Balloon: Preliminary Results from the PATENT-C First-in-Human Study Gary Gershony 3:52 pm - Discussion with Q&A Session III. Peripheral Programs Update Moderators: Christoph K. Naber, Dierk Scheinert 4:07 pm - Role of DCB in SFA Intervention: Predictions Five Years into the Future Thomas Zeller 4:15 pm - DEBATE-BTK: A Prospective, Randomized Trial of Paclitaxel Coated Balloon Angioplasty in Diabetic Patients with Critical Limb Ischemia Undergoing Angioplasty of Below-the-Knee Vessels Francesco Liistro 4:23 pm - The DEFINITIVE-AR Trial: Clinical Update Gunnar Tepe 4:31 pm - The Invatec-Medtronic Peripheral PCB Program William A. Gray 4:39 pm - The BIOLUX-P-I Trial: Clinical and Angiographic Results Dierk Scheinert 4:49 pm - The LEVANT II US-Pivotal Study Update Dierk Scheinert 4:54 pm - Discussion with Q&A Session IV. Research and Development Perspectives Moderators: Juan F. Granada, William A. Gray 5:11 pm - Regulatory Requirements for DCB Development and Approval in the United States Kenneth J. Cavanaugh Jr 5:21 pm - DCB Cost-Effectiveness Analysis: What Results Must Be Seen for Success in the United Statee? Duane S. Pinto 5:31 pm - Future DCB Technologies: Challenges and Opportunities Juan F. Granada 5:41 pm - Discussion with Q&A 5:56 pm - Adjourn International Debating Chamber: Interventional Cardiology on Trial Sponsored by the British Cardiovascular Intervention Society This session is only CME accredited. 2:00 pm-6:00 pm Room A :00 pm - Introduction, Session Outline, and Goals Anthony H. Gershlick Conflagration I. Revascularization in Patients with Diabetes Mellitus and Multivessel Disease Moderators: Nick Curzen, Anthony H. Gershlick Discussants: Andreas Baumbach, Robert A. Henderson, A. Pieter Kappetein, D. Craig Miller, William S. Weintraub 2:03 pm - Session and Participant Introduction Anthony H. Gershlick 2:06 pm - Case Presentation Introduction: A Young Diabetic Patient with Multivessel Disease Referred for PCI Daniel J. Blackman Motion: PCI Is the Optimum Revascularization Strategy for Most Diabetics with Multivessel Disease 2:09 pm - Pro: All Diabetic Patients with Multivessel Disease Should Be Offered PCI! Carlo Di Mario 2:19 pm - Con: CABG Is a Superior Revascularization Strategy for Most Patients with Multivessel Disease! D. Craig Miller 2:29 pm - Discussion: Jury Deliberations (Issue in General and Patient Specific) 2:49 pm - Panel and Audience Vote 2:52 pm - Case Presentation Conclusion: Procedural and Late Patient Outcomes Daniel J. Blackman Thursday - October 25,

154 Thursday, October 25 2:55 pm - Final Judicial Sentence and Take-home Messages Anthony H. Gershlick Conflagration II. TAVR with Diseased Femoral Arteries Moderators: Martin B. Leon, Martyn R. Thomas Discussants: Daniel J. Blackman, Joseph P. Carrozza Jr, Robert A. Henderson, Philip A. MacCarthy, Zoltan G. Turi 3:00 pm - Session and Participant Introduction Martyn R. Thomas 3:03 pm - Case Presentation Introduction: Patient with Severe AS and Diseased Femoral Arteries Offered Transapical TAVR Mark A. de Belder Motion: The Transaortic Approach Should Move the Transapical Approach to the History Books 3:06 pm - Pro: The Transaortic Approach Has Clear Benefits Over the Transapical Approach! Vinayak Bapat 3:16 pm - Con: There Are No Good Data for the Transaortic Approach, and Transapical Results Are Improving! Todd M. Dewey 3:26 pm - Discussion: Jury Deliberations (Issue in General and Patient Specific) 3:46 pm - Panel and Audience Vote 3:49 pm - Case Presentation Conclusion: Procedural and Patient Outcomes Mark A. de Belder 3:52 pm - Final Judicial Sentence and Take-home Messages Martin B. Leon Conflagration III. Timing of Revascularization in Non-ST-Segment Elevation Acute Coronary Syndrome Moderators: Mark A. de Belder, Stefan K. James Discussants: Daniel J. Blackman, Miles C. Dalby, William S. Weintraub 3:57 pm - Session and Participant Introduction Mark A. de Belder 4:00 pm - Case Presentation Introduction: A Patient with Acute Coronary Syndrome Undergoing Immediate PCI Miles C. Dalby Motion: High-Risk Non-ST-Segment Elevation ACS Should Be Treated Like Primary Angioplasty 4:03 pm - Pro: Delaying Is of No Benefit and Only Increases Health Costs: Why Wait?! Gilles Montalescot 4:13 pm - Con: Patients Benefit from Cooling Off with Pharmacological Stabilization! Anthony H. Gershlick 4:25 pm - Discussion: Jury Deliberations (Issue in General and Patient Specific) 4:45 pm - Panel and Audience Vote 4:48 pm - Case Presentation Conclusion: Procedural and Late Patient Outcomes Miles C. Dalby 4:51 pm - Final Judicial Sentence and Take-home Messages Stefan K. James Conflagration IV. Timing of Complete Revascularization in Acute Myocardial Infarction Moderators: Adnan Kastrati, Philip A. MacCarthy Discussants: Daniel J. Blackman, David J. Cohen, Nick Curzen, Anthony H. Gershlick, Ronen Jaffe 4:56 pm - Session and Participant Introduction Philip A. MacCarthy 4:59 pm - Case Presentation Introduction: Patient Undergoes Primary Angioplasty and Is Found to Have Lesions in Two Non- Infarct-Related Arteries Andreas Baumbach Motion: The Goal of Primary Angioplasty Is to Recanalize the Infarct Related Artery Only 5:02 pm - Pro: Treating Bystander Disease in the Primary PCI Setting Increases Risk! Ran Kornowski 5:12 pm - Con: Patients Should Undergo Complete Revascularization in One Sitting: Longer Term Outcomes Will Be Superior! Sanjit S. Jolly 5:22 pm - Discussion: Jury Deliberations (Issue in General and Patient Specific) 5:42 pm - Panel and Audience Vote 5:45 pm - Case Presentation Conclusion: Procedural and Patient Outcomes Andreas Baumbach 5:48 pm - Final Judicial Sentence and Take-home Messages Adnan Kastrati 6:00 pm - Adjourn Next-Generation Intravascular Imaging and Physiology: RF-IVUS, OCT, NIR Spectroscopy, ifr, and CT-FFR 2:00 pm-6:08 pm Room A This session is only CME accredited. Session I. Determining Lesion Significance Moderators: Allen Jeremias, Morton J. Kern Discussants: Joseph D. Babb, Jozef Bartunek, Michalis Hamilos, Michael J. Lim 2:00 pm - Foundation Talk: New Modalities to Assess Lesion Significance: How Should They Be Evaluated? Bon-Kwon Koo 2:10 pm - CT-FFR: Background and Clinical Data James K. Min 2:22 pm - ifr: Background and Clinical Data Justin E. Davies 2:34 pm - Correlation Between FFR and ifr: An Independent Validation Study Nils Johnson 2:44 pm - Basal Stenosis Resistance Index: Background and Clinical Data Tim P. van de Hoef 2:54 pm - A Challenge to All Basal Modalities: Why They Can Never Be as Good as Hyperemic Indices Nico H.J. Pijls 3:04 pm - OCT/FFR Correlation: Do the Combined Technologies Have a Role in Assessing Lesion Severity? Javier Escaned 3:14 pm - Discussion with Q&A Session II. Guiding Percutaneous Coronary Interventions: IVUS, RF-IVUS, OCT, and NIR Spectroscopy Moderators: Giulio Guagliumi, Guillermo Tearney Discussants: Marco A. Costa, Hector M. Garcia-Garcia, Massoud A. Leesar, Evelyn S. Regar 3:29 pm - OCT to Risk Stratify and Guide PCI Procedures 1: Preintervention Assessment Takashi Kubo 3:39 pm - OCT to Risk Stratify and Guide PCI Procedures 2: Postintervention Assessment Francesco Prati 3:49 pm - Beyond OFDI: Next-Generation OCT Systems Brett E. Bouma 3:59 pm - Identifying and Managing Embolic-Prone Lesions: IVUS, RF-IVUS, OCT, and NIRS Emmanouil S. Brilakis 152

155 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics 4:09 pm - New VH-IVUS Insights from PROSPECT and HORIZONS-AMI Akiko Maehara 4:19 pm - Discussion with Q&A Session III. Case Presentations Moderators: Akiko Maehara, Evelyn S. Regar Discussants: Carlo Di Mario, Marc D. Feldman, James A. Goldstein, Robert L. Wilensky 4:31 pm - Case 1: OCT Case Jingbo Hou 4:41 pm - Case 2: VH-IVUS Case Dariusz Dudek 4:51 pm - Case 3: NIRS Case Ryan D. Madder 5:01 pm - Case 4: IFR Case Sayan Sen Thursday - October 25, 2012 Session IV. Early and Late Stent Outcomes: Insights from New Imaging Modalities Moderators: Emmanouil S. Brilakis, Gary S. Mintz Discussants: Fernando Alfonso, Giulio Guagliumi, Yasuhiro Honda 5:11 pm - Mechanisms and Predictors of Stent Thrombosis and Restenosis: Insights from Grayscale and VH-IVUS Akiko Maehara 5:21 pm - Mechanisms and Predictors of Stent Thrombosis and Restenosis: Insights from OCT Evelyn S. Regar 5:31 pm - Mechanisms and Predictors of Stent Thrombosis and Restenosis: Insights from NIRS James A. Goldstein 5:41 pm - BVS Follow-up Using Multiple Imaging Modalities: Research Implications vs. Clinical Utility Yoshinobu Onuma 5:53 pm - Discussion with Q&A 6:08 pm - Adjourn Evening Programs 7:00 pm-8:30 pm Please see page 176 for the Evening Programs schedule

156 CARDIOVASCULAR RESEARCH FOUNDATION A Passion for Innovation Pioneering New Therapies for the Treatment of Heart Disease More than 81 million people live with heart disease worldwide. Many of them will benefit from interventional procedures developed or refined by the Cardiovascular Research Foundation (CRF).... WE INVESTIGATE Early Stage Technologies During Preclinical Research WE EVALUATE Promising New Therapies by Designing and Implementing Multiple Phases of Human Clinical Trials WE EDUCATE Medical Professionals and the Public to Enhance Patient Outcomes Visit us at the Partnership Pavilion located in Hall D, Level 1.

157 Breakfast Meetings Main Arena How to Treat Theater: Coronary Artery Disease Morning Spotlight Sessions RESPECT and PC Trial Deep Dive: Implications for PFO Closure to Prevent Cryptogenic Stroke TAVR Site Readiness: Starting a Program and Achieving Optimal Outcomes The STEMI Center of Excellence: Strategies to Optimize Outcomes in AMI Lunchtime Sessions Hot Topics Learn the Technique FRiday October 26, 2012 Miami Beach Convention Center miami, FL The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics

158 friday, October 26 Breakfast Meetings 7:00 am-8:00 am Please see page 179 for the Breakfast Meeting schedule. Main Arena 8:00 am-3:15 pm Hall D Plenary Session XXII. Live Cases VII Live Case Moderator: Martin B. Leon Live Case Co-Moderator: Ganesh Manoharan Live Case Discussants: Jeroen J. Bax, Daniel J. Blackman, Roberto Corti, Larry S. Dean, Ulrich J. Gerckens, Victor Guetta, Rainer Hoffmann, Paul Hsien-Li Kao, Karl-Heinz Kuck, Reginald I. Low, Raj Makkar 8:00 am - University Hospital Bonn Bonn, Germany 8:45 am - Hôpital Charles Nicolle Rouen, France Plenary Session XXIII. Transcatheter Aortic Valve Replacement 2012 Moderators: Ian T. Meredith, Martyn R. Thomas Discussants: David H. Adams, Martin B. Leon, Reginald I. Low, D. Craig Miller, Neil E. Moat, Patrick T. O Gara, Nicolo Piazza, Jeffrey J. Popma, Allan Schwartz, Wilson Y. Szeto 9:30 am - State of TAVR in 2012: Appropriate Clinical Indications and Ongoing Controversies Martyn R. Thomas 9:45 am - A Surgeon s Perspective on TAVR Clinical Use Patterns in Europe Neil E. Moat 9:55 am - Update on the Commercial Launch of TAVR in the United States: Site Selection, Training, Clinical Indications, Case Volumes, and Clinical Outcomes Martin B. Leon 10:05 am - Discussion Plenary Session XXIV. Vascular Drug Delivery Breakthroughs Moderators: Andrea Abizaid, Juan F. Granada Discussants: David J. Cohen, Antonio Colombo, Stephen G. Ellis, Run-Lin Gao, Adnan Kastrati, Pedro A. Lemos, John A. Ormiston, Sahil A. Parikh, Gregg W. Stone, Renu Virmani, Ron Waksman, Alan C. Yeung 10:20 am - Bioabsorbable Drug-Eluting Scaffolds Are the Future! The Science Behind the Dream Patrick W. Serruys 10:35 am - Current and Future Clinical Applications of Drug-Coated Balloons: From Bench to Bedside Bruno Scheller 10:50 am - Discussion Plenary Session XXV. TCT 2012 Thomas J. Linnemeier Spirit of Interventional Cardiology Young Investigator Award Moderator: Gregg W. Stone 11:00 am - TCT 2012 Thomas J. Linnemeier Spirit of Interventional Cardiology Young Investigator Award Award Presenter: Gregg W. Stone, Howard C. Herrmann Award Finalists: Ehrin J. Armstrong, Philippe Généreux, Giulio Stefanini Plenary Session XXVI. Late Breaking Trials III Moderator: Gregg W. Stone Co-Moderator: Patrick W. Serruys Discussants: Olivier F. Bertrand, Michael J. Cowley, Donald Cutlip, Frederick Feit, Martial Hamon, Adnan Kastrati, Ian T. Meredith, Graham Nichol, Matthew J. Price, St phane Rinfret, Sigmund Silber, Zoltan G. Turi, Stephen D. Wiviott 11:15 am - XIMA: A Prospective, Randomized Trial of Everolimus-Eluting Stents vs. Bare-Metal Stents in Octogenarians Adam J. de Belder 11:27 am - Discussion 11:35 am - ISAR-DESIRE 3: A Prospective, Randomized Trial of Paclitaxel-Eluting Balloons vs. Paclitaxel- Eluting Stents vs. Balloon Angioplasty for Restenosis of Limus -Eluting Coronary Stents Robert A. Byrne 11:47 am - Discussion 11:55 am - STEMI-RADIAL: A Prospective, Randomized Trial of Radial vs. Femoral Access in Patients with ST-Segment Elevation Myocardial Infarction Ivo Bernat 12:07 pm - Discussion Plenary Session XXVII. TCT 2012 Late Breaking Trials Critique and Interpretation Moderator: Gregg W. Stone Discussants: Andrea Abizaid, David J. Cohen, Antonio Colombo, Donald Cutlip, Carlo Di Mario, William F. Fearon, William A. Gray, Spencer B. King III, Ajay J. Kirtane, Franz-Josef Neumann, Seung-Jung Park, Patrick W. Serruys, William S. Weintraub, Giora Weisz 12:07 pm - TCT 2012 Late Breaking Trials Critique and Interpretation Plenary Session XXVIII. TCT 2012 Masters Series Moderators: Martin B. Leon, Gary S. Mintz, Gregg W. Stone Discussants: Andrea Abizaid, John A. Ambrose, George D. Dangas, Juan F. Granada, William A. Gray, Cindy L. Grines, Ajay J. Kirtane, Marie-Claude Morice, Wesley R. Pedersen, Patrick W. Serruys, Giora Weisz 1:00 pm - Seminal Pathobiologic Insights Which Have Shaped and Guided Interventional Cardiovascular Medicine Renu Virmani 1:15 pm - Discussion 1:20 pm - The Odyssey of Transcatheter Aortic Valve Replacement (TAVR): From Concept to Clinical Reality: A 10-Year Anniversary Celebration Martin B. Leon 1:35 pm - Discussion 1:40 pm - Reflections on Coronary Stents: From Bare Metal to Drug-Eluting to Bioabsorbable: My Personal Delights and Dilemmas Antonio Colombo 1:55 pm - Discussion 2:00 pm - The Revolutionary Impact of Interventional Imaging and Physiologic Assessment: Milestones Met and a Future Vision Gary S. Mintz 156

159 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics 2:15 pm - Discussion 2:20 pm - The Interventional Pharmacotherapy Legacy: Facilitating and Transforming Clinical Outcomes Gregg W. Stone 2:35 pm - Discussion 2:40 pm - The Future of Clinical Research: Migrating to an Era of Informatics and Personalized Medicine Robert M. Califf 2:55 pm - A Subspecialty at the Crossroads: Financial Constraints, the Affordable Care Act, Resource Allocations, Physician Training, and Medical Education: Bold Predictions for the Next 10 Years! John C. Lewin 3:10 pm - Discussion 3:15 pm - Adjourn How to Treat Theater: Coronary Artery Disease 7:50 am-1:00 pm Hall A-Coronary Theater This session is only CME accredited. Complex and Unusual Coronary Intervention III Moderator: Ajay J. Kirtane Co-Moderator: Maurice Buchbinder 8:00 am - Coronary Complication Spectacle: From Air Emboli to Dislodged Stents to No Reflow, Perforations, and More John S. Douglas Jr 8:15 am - Coronary Aneurysms and AV Fistulae: When and How to Treat Charanjit S. Rihal Live Cases: Complex and Unusual Coronary Intervention III Live Case Moderator: Ajay J. Kirtane Live Case Co-Moderator: Maurice Buchbinder Live Case Discussants: Kevin J. Beatt, Charles E. Chambers, Giulio Guagliumi, Allen Jeremias, Vincent On-Hing Kwok, Roger J. Laham, Henry H. Ting, Robert L. Wilensky, Bernhard Witzenbichler 8:30 am - Mount Sinai Medical Center Miami, FL 9:30 am - University Hospital Bonn Bonn, Germany Transcatheter Valve Therapies III Moderator: Jeffrey J. Popma Co-Moderator: Gerhard C. Schuler 10:30 am - TAVR Technology and Techniques: Transcatheter Valve Systems, Accessory Devices, and Alternative Access Sites Nicolo Piazza 10:45 am - The Expert MitraClip Procedure: From Transseptal Puncture to Echocardiographic Guidance and Procedural Tips and Tricks Saibal Kar Live Cases: Transcatheter Valve Therapies III Live Case Moderator: Jeffrey J. Popma Live Case Co-Moderator: Gerhard C. Schuler Live Case Discussants: Shmuel Banai, Andreas Baumbach, David L. Brown, Jose A. Condado, Eulogio J. Garcia, Isaac George, Vivek Gupta, Jean-Claude Laborde, David Planer 11:00 am - Hôpital Charles Nicolle Rouen, France 12:00 pm - University Hospital Bonn Bonn, Germany 1:00 pm - Adjourn Morning Spotlight Sessions RESPECT and PC Trial Deep Dive: Implications for PFO Closure to Prevent Cryptogenic Stroke 8:00 am-12:00 pm Room A This session is only CME accredited. Part I Moderators: Horst Sievert, Robert J. Sommer, David E. Thaler Discussants: John D. Carroll, Sanjay Kaul, Jeffrey L. Saver, Richard Smalling, Stephan Windecker 8:00 am - PC Trial Recap Stephan Windecker 8:15 am - PC Trial: Additional Findings Stephan Windecker 8:30 am - RESPECT: Primary Results and More New Data John D. Carroll 8:45 am - RESPECT: Insights into Ischemic Stroke and Its Treatment Jeffrey L. Saver 9:00 am - The PFO Closure Procedure: Safety and Effectiveness Lessons from RESPECT Richard Smalling 9:15 am - Study Design Issues with RESPECT and the PC Trial Sanjay Kaul 9:30 am - Discussion Part II Moderators: John D. Carroll, Shunichi Homma, Bray Patrick-Lake Discussants: David E. Thaler, Brian K. Whisenant 10:15 am - Best Echo Practices and Identifying the Pathogenic PFO Shunichi Homma 10:30 am - Paradoxical Embolism and Stroke: Insights from RESPECT David E. Thaler 10:45 am - With These Randomized Data: What s Next for Clinical Practice, Device Development, and Future Research? Brian K. Whisenant 11:00 am - With These Randomized Data: The Patient s Perspective Bray Patrick-Lake 11:15 am - Discussion 12:00 pm - Adjourn TAVR Site Readiness: Starting a Program and Achieving Optimal Outcomes 8:00 am-12:00 pm Room A The Multidisciplinary TAVR Heart Team: Core Concepts and Cultural Transformation Moderators: Nicolo Piazza, Mathew Williams Discussants: Henning Rud Andersen, Russell A. Brandwein, Benoit Daneault, Philippe Généreux, Marian C. Hawkey, Hasan Jilaihawi, Scott Lim, Tamim Nazif, Jean-Michel Paradis, Wilson Y. Szeto, Brian K. Whisenant, David A. Wood, Steven J. Yakubov 8:00 am - Keynote Lecture 1: What Is a Heart Team, and Why Is it Essential for a Successful TAVR Program? Nicolo Piazza 8:12 am - Discussion 8:15 am - The Surgeon as Gatekeeper and Engaged Partner in TAVR Wilson Y. Szeto Friday - October 26,

160 friday, October 26 8:23 am - Discussion 8:25 am - The TAVR Interventionalist: Specialized Skill Requirements Scott Lim 8:33 am - Discussion 8:35 am - Tips and Tricks for a Facilitated Early Discharge Plan After TAVR Procedures David A. Wood 8:43 am - Discussion 8:45 am - The Crucial and Complementary Roles of Advanced Imaging (Echo and CT) in TAVR Hasan Jilaihawi 8:53 am - Discussion 8:55 am - Non-Physician Experts Are the Soul of the TAVR Heart Team Marian C. Hawkey 9:03 am - Discussion 9:05 am - A Live Multidisciplinary TAVR Heart Team Case Presentation Tamim Nazif, Jean-Michel Paradis 9:11 am - Discussion Discussants: Russell A. Brandwein, Marian C. Hawkey, Scott Lim, Mathew Williams Patient Screening Is the Key to TAVR Success Moderators: Susheel Kodali, Augusto D. Pichard Discussants: Vasilis Babaliaros, Bruce Bowers, David L. Brown, Mauricio G. Cohen, Haim Danenberg, Isaac George, Philip Green, Ran Kornowski, Susan J. Schnell, Nicolas M. van Mieghem 9:25 am - Keynote Lecture 2: Essentials of Risk Stratification for TAVR: Moderate, High, and Extreme Risk, Futility, and More... Jeffrey J. Popma 9:37 am - Discussion 9:40 am - The Importance of Frailty Assessments in TAVR Patient Screening Philip Green 9:48 am - Discussion 9:50 am - Developing an Efficient and Effective TAVR Patient Screening Process: Outreach Programs, Valve Clinics, Screening Workups, and Case Scheduling Bruce Bowers 9:58 am - Discussion 10:00 am - Managing Expectations in the Real World: Communication with Referring Physicians, Families, and Patients Susan J. Schnell 10:08 am - Discussion TAVR Site Evaluations, Training, and Logistics Moderators: Susheel Kodali, Mathew Williams Discussants: Vasilis Babaliaros, Michael J. Davidson, Ulrich J. Gerckens, James B. Hermiller Jr, Jean-Claude Laborde, Alan B. Lumsden, Michael J. Reardon, Rhonda Robb, Kristen Skelton 10:10 am - Guidelines for Selecting a TAVR Site in the United States Kristen Skelton 10:18 am - Discussion 10:20 am - Criteria for TAVR Site Selection Outside the United States Jean-Claude Laborde 10:28 am - Discussion 10:30 am - Creating the Optimal TAVR Procedural Venue: Hybrid Cath Lab/ORs, Staffing, Stocking, and Other Logistics Alan B. Lumsden 10:38 am - Discussion 10:40 am - TAVR Training Programs and Case Proctoring Vasilis Babaliaros 10:52 am - Discussion 10:55 am - Keynote Lecture 3: The US Commercial TAVR Site Activation Program: Update, Analysis, Report Card, and Future Expectations Susheel Kodali 11:07 am - Discussion Managing a Successful TAVR Program Moderators: Nicolo Piazza, Martyn R. Thomas Discussants: Perry Bridger, Maurice Buchbinder, Patricia E. Knipper, Jean-Michel Paradis, Anna Sonia Petronio 11:10 am - The In-Patient Heart Valve Clinical Service: Optimizing Care for TAVR and Non-TAVR Patients Jean-Michel Paradis 11:18 am - Discussion 11:20 am - Introducing the TVT Registry: Concept, Current Status, and Future Directions Susheel Kodali 11:28 am - Discussion Reimbursement for TAVR Procedures in the United States 11:30 am - Understanding and Complying with the CMS National Coverage Determination Perry Bridger 11:35 am - Realities and Recommendations from a Commercial TAVR Site Perspective Patricia E. Knipper 11:40 am - Discussion 11:45 am - Open Roundtable Discussion: Among New TAVR Commercial Sites in the United States, the Secrets of a Successful Program Moderators: Susheel Kodali, Mathew Williams Discussants: Frank Bowen, George D. Dangas, Augustin Delago, John Goncalves, David M. Mego, Michael Nolen, Joshua Rovin, Richard Keith Schwartz, Douglas Spriggs 12:00 pm - Adjourn The STEMI Center of Excellence: Strategies to Optimize Outcomes in AMI 8:00 am-12:00 pm Room A Controversies in STEMI Systems of Care Moderators: Christian W. Hamm, Ivan C. Rokos Discussants: Eric R. Bates, Holger Thiele 8:00 am - The New European STEMI Guidelines: What Are the Differences from US Guidelines and Why? Christian W. Hamm 8:15 am - New Guideline Door-to-Balloon Time of 120 Minutes for Transferred STEMI Patients: Taking a Knee or Evidence- Based Decision? Eric R. Bates 8:30 am - Pharmacoinvasive Approach vs. Primary PCI for Transferred STEMI Patients Holger Thiele 8:45 am - Discussion with Q&A Mission Lifeline Moderators: Alice K. Jacobs, Gary L. Schaer Discussants: Sameer Mehta, Ivan C. Rokos 9:00 am - Mission Accomplished and Saving Lives? Alice K. Jacobs 9:12 am - Why Are Some Hospital Networks More Successful? Sameer Mehta 9:24 am - False Activations of the Cath Lab: New Insights and Recommendations Gary L. Schaer 9:36 am - Do We Need Payment Incentives to Optimize STEMI Networks? Ivan C. Rokos 9:48 am - Discussion with Q&A Strategies to Shorten Reperfusion Times Moderators: William J. French, Sameer Mehta Discussants: Eric A. Cohen, Michel R. Le May 10:00 am - Potential and Pitfalls of Ambulance Triage and STEMI Transfer Networks Eric A. Cohen 158

161 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics 10:15 am - Old and New Strategies to Reduce D2B Times Sameer Mehta 10:30 am - Prehospital ECG Transmission and the Call 911 Protocol for STEMI Referral Centers William J. French 10:40 am - Is it Time for Regional Cardiac Arrest Programs? Code ROSC in Ottawa Michel R. Le May 10:50 am - Discussion with Q&A Performance Measures for STEMI and PCI Moderators: Brahmajee K. Nallamothu, Henry H. Ting Discussant: Jeptha P. Curtis 11:00 am - Performance Measures in PCI and STEMI: Do They Improve Care or Restrict Decision-Making? Brahmajee K. Nallamothu 11:15 am - Volume-Outcome Relationships for STEMI: Is More Better? Jeptha P. Curtis 11:30 am - Risk-Standardized 30-Day Mortality Rates: What Are They and How Do We Improve Them? Henry H. Ting 11:45 am - Discussion with Q&A 12:00 pm - Adjourn Lunchtime Sessions Hot Topics ACC Special Practitioners Session at TCT: How to Manage, Maintain, and Expand Your Clinical Practice 12:15 pm-1:45 pm Room C This session is only CME accredited. Moderators: Tony Das, D. Christopher Metzger, Lowell F. Satler Discussants: Eric J. Dippel, Roger Gammon 12:15 pm - Using Data ( Cloud ) Integration to Improve Your Practice s Responsiveness and Regional Outreach Lowell F. Satler 12:27 pm - Discussion with Q&A 12:30 pm - Should Clinical Research Be an Important (or Profitable) Part of Your Practice? How to Succeed D. Christopher Metzger 12:42 pm - Discussion with Q&A 12:45 pm - Reinventing Yourself: How to Add New Procedures (eg, Peripheral, Carotid, TAVR, Structural) Tony Das 12:57 pm - Discussion with Q&A 1:00 pm - How to Maximize Practice Performance in Large Practices: Independent or Hospital Integrated? Generalist or Subspecialization? Equal Split or Productivity Based? And More Eric J. Dippel 1:12 pm - Discussion with Q&A 1:15 pm - How to Maximize Referrals to Your Practice: Is the Spoke and Hub Model Dead? Roger Gammon 1:27 pm - Discussion with Q&A 1:30 pm - Roundtable Discussion 1:45 pm - Adjourn Career Development for the New Interventionalist 12:15 pm-1:45 pm Room C This session is only CME accredited. Moderators: Sahil A. Parikh, Manish A. Parikh 12:15 pm - Introduction Manish A. Parikh 12:20 pm - Getting Started in an Academic Group Practice: What to Do and What Not to Do Michael J. Rinaldi 12:30 pm - Getting Started in a University Practice: What to Do and What Not to Do Robert W. Yeh 12:40 pm - Building a Niche: How to Transition from the New Interventionalist to the Expert James P. Zidar 12:50 pm - Balancing Multiple Skills: Coronary and Peripheral Sahil A. Parikh 1:00 pm - Balancing Multiple Skills: Coronary and Structural Susheel Kodali 1:10 pm - Balancing Multiple Skills: Avoiding Getting Spread Too Thin Jennifer A. Tremmel 1:20 pm - Juggling Clinical Practice and Clinical Research Matthew J. Price 1:30 pm - Things to Do in Your First Five Years to Grow Your Career Manish A. Parikh 1:40 pm - Discussion: Tips, Tricks, and Rookie Mistakes When Starting as an Interventionalist 1:45 pm - Adjourn Diabetes and Cardiovascular Disease: Treating the Whole Patient 12:15 pm-1:45 pm Room C Moderators: Michael E. Farkouh, Frederick Feit, Steven P. Marso 12:15 pm - Introduction and Session Goals Frederick Feit 12:17 pm - Diabetes Mellitus, Multivessel, and Left Main Disease: CABG for All! Joseph F. Sabik 12:27 pm - Diabetes Mellitus, Multivessel, and Left Main Disease: Not So Fast, PCI for Many! Kevin J. Beatt 12:37 pm - Discussion: Diabetes Multivessel and Left Main Disease: CABG vs. PCI Discussants: Kevin J. Beatt, Francesco Burzotta, Upendra Kaul, Joseph F. Sabik 12:47 pm - Introducing Disruptive DES Technology into BARI 2D: Lessons Learned, Insights Gained Frederick Feit 12:57 pm - Optimizing the Diabetic Formulary: Managing the Triad of Glycemic Control, Blood Pressure, and Hyperlipidemia Michael E. Farkouh 1:07 pm - Evaluating the Safety of Emerging Diabetic Therapies Steven P. Marso 1:17 pm - Discussion: Optimizing Medical Therapy for Diabetic Patients in 2012 Discussants: Michael E. Farkouh, Frederick Feit, Steven P. Marso, Verghese Mathew 1:27 pm - Case: A 62-Year-Old Diabetic Patient with ACS and Moderate Renal Failure Verghese Mathew 1:42 pm - Concluding Remarks Frederick Feit 1:45 pm - Adjourn Guideline Directions and Controversies (Part 2): Decision Making with the Heart Team Approach 12:15 pm-1:45 pm Room D This session is only CME accredited. Moderators: Brahmajee K. Nallamothu, Henry H. Ting Discussants: Joseph D. Babb, Eric R. Bates, Megan Coylewright, Isaac George, Thomas D. Stuckey Friday - October 26,

162 friday, October 26 Case Presentations: Introduction 12:15 pm - Case 1: Patient with Stable Class 1 Angina Treated with Aspirin and Statin and a Mid LAD 70% Stenosis Megan Coylewright 12:20 pm - Case 2: Patient with Stable Class 3 Angina, Triple-Vessel CAD, and Intermediate Syntax and STS Scores Megan Coylewright 12:25 pm - What Do the Guidelines and Appropriate Use Criteria Recommend? Eric R. Bates The Heart Team Panel: How Do We Decide on Alternative Treatments? 12:35 pm - Referring Cardiologist Perspective Joseph D. Babb 12:40 pm - Interventional Cardiologist Perspective Thomas D. Stuckey 12:45 pm - Cardiac Surgeon Perspective Isaac George 12:50 pm - What Is the Role for Shared Decision Making? Henry H. Ting 1:00 pm - Controversies and Bringing It All Together Brahmajee K. Nallamothu 1:10 pm - Discussion with Q&A Case Presentations: Discussion and Resolution 1:25 pm - Case 1: Patient with Stable Class I Angina Treated with Aspirin and Statin and a Mid LAD 70% Stenosis Megan Coylewright 1:35 pm - Case 2: Patient with Stable Class III Angina, Triple-Vessel CAD, and Intermediate Syntax and STS Scores Megan Coylewright 1:45 pm - Adjourn Prevention of Contrast-Induced Acute Kidney Injury: Focus on Hydration and New Frontiers 12:15 pm-1:45 pm Room C Moderators: Antonio L. Bartorelli, Roxana Mehran, Richard Solomon Discussants: Somjot S. Brar, Carlo Briguori, Fikret Er, Eugenia Nikolsky 12:15 pm - Welcome, Introduction, and Session Goals Antonio L. Bartorelli 12:20 pm - Contrast-Induced Acute Kidney Injury: Have We Reached a Ceiling in Prevention? Roxana Mehran 12:30 pm - Balancing Diuresis and Hydration to Prevent CI-AKI Richard Solomon 12:40 pm - Alternative Approaches for Hydration: MYTHOS, REMEDIAL II, and Others Antonio L. Bartorelli 12:50 pm - A Well Calculated Hydration Scheme: The Role of Heart Pressure to Gauge Hydration Somjot S. Brar 1:00 pm - A Guide to Hydration Modalities: Normal Saline vs. Bicarbonate, Timing, and Duration Carlo Briguori 1:10 pm - Ischemic Preconditioning to Prevent CIN: Hype or Hope? Fikret Er 1:20 pm - A Case-Based Discussion: Take-home Messages and Clinical Practice Implications Eugenia Nikolsky 1:25 pm - Discussion with Q&A 1:45 pm - Adjourn Learn the Technique These sessions are only CME accredited. Acute Infarct Angioplasty and Cardiogenic Shock 12:15 pm-1:45 pm Room B211 Moderators: Simon R. Dixon, Bernhard Witzenbichler Discussants: David A. Cox, James A. Goldstein, Jose P.S. Henriques, John C. Messenger 12:15 pm - Cases 1 and 2: When and How to Use Aspiration and Mechanical Thrombectomy David A. Cox 12:30 pm - Cases 3 and 4: What to Consider When Treating Acute Stent Thrombosis Bernhard Witzenbichler 12:45 pm - Cases 5 and 6: How to Intervene in Acute Saphenous Vein Graft Occlusion Simon R. Dixon 1:00 pm - Cases 7 and 8: When and How to Use LV Support Devices in Acute MI Jose P.S. Henriques 1:15 pm - Cases 9 and 10: How to Manage Acute MI with Right Ventricular Shock James A. Goldstein 1:30 pm - Cases 11 and 12: Complications of Acute Infarct Angioplasty John C. Messenger 1:45 pm - Adjourn Left Main Intervention 12:15 pm-1:45 pm Room A208 Moderators: Andrejs Erglis, Raj Makkar Discussants: James B. Hermiller Jr, William W. O Neill, Stéphane Rinfret 12:15 pm - Important Facts from the Literature Relevant for Day-to-Day Left Main PCI Raj Makkar 12:25 pm - Step-by-Step Approach to Two-Stent Techniques for Left Main Bifurcation PCI: Coulette, Mini-Crush, Double Barrel, and More Andrejs Erglis 12:35 pm - Discussion with Q&A 12:45 pm - How to Perform Left Main PCI via the Radial Approach Stéphane Rinfret 12:55 pm - How to Use FFR and IVUS During Left Main PCI James B. Hermiller Jr 1:05 pm - When and What to Use for LV Support in Left Main PCI William W. O Neill 1:15 pm - Debulking and Plaque Modification in Left Main PCI: When and How Antonio Colombo 1:25 pm - My Most Important Lessons from Two Decades of Left Main PCI Seung-Jung Park 1:35 pm - Discussion with Q&A 1:45 pm - Adjourn Management of DES Thrombosis and Restenosis 12:15 pm-1:45 pm Room B210 12:15 pm - Welcome and Introduction Fernando Alfonso Stent Thrombosis Moderators: Fernando Alfonso, Christoph A. Kaiser 12:17 pm - Update: Everything You Need to Know About Stent Thrombosis Management in 2012 Alaide Chieffo 12:29 pm - Case 1: Subacute DES Thrombosis After Elective PCI (with Imaging) Francesco Prati 12:39 pm - Case 2: DES Thrombosis After STEMI Tamim Nazif 12:49 pm - Case 3: Very Late Stent Thrombosis: The Role of Adjunctive Imaging During Treatment Giulio Guagliumi 160

163 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics Restenosis Moderators: Fernando Alfonso, Philip M. Urban 12:59 pm - Update: Everything You Need to Know about Treatment of Restenosis in 2012 Alan C. Yeung 1:11 pm - Case 1: Management of Focal DES ISR Ioannis Iakovou 1:21 pm - Case 2: Management of DES ISR with Drug-Coated Balloon Andrzej J. Ochala 1:31 pm - Case 3: Management of Late Restenosis Due to Neoatherosclerosis with Plaque Rupture Robert A. Byrne 1:41 pm - Take-home Lessons Fernando Alfonso 1:45 pm - Adjourn Transcatheter Aortic Valve Replacement: Tips and Tricks 12:15 pm-1:45 pm Room A209 Moderators: Corrado Tamburino, Martyn R. Thomas Discussants: Raoul Bonan, Lutz Buellesfeld, Haim Danenberg, Michael J. Reardon, Stefan Sack, Gerhard C. Schuler, Nicolas M. van Mieghem 12:15 pm - Introduction to the TAVR Procedure Martyn R. Thomas 12:20 pm - Case 1: Paravalvular Leak Augusto D. Pichard 12:28 pm - How to Minimize Paravalvular Leak Corrado Tamburino 12:35 pm - Discussion with Q&A 12:40 pm - Case 2: Alternative (Nonfemoral) Vascular Access Nicolas M. van Mieghem 1:08 pm - Strategies for Accurate Valve Placement Martyn R. Thomas 1:15 pm - Discussion with Q&A 1:20 pm - Case 4: TAVR-Related Stroke Gerhard C. Schuler 1:28 pm - Minimizing Stroke During TAVR Samir R. Kapadia 1:35 pm - Discussion with Q&A 1:40 pm - Conclusions and Take-home Messages Corrado Tamburino 1:45 pm - Adjourn Friday - October 26, :48 pm - What Are the Preferred Access Options in Nontransfemoral Cases? Daniel J. Blackman 12:55 pm - Discussion with Q&A 1:00 pm - Case 3: Incorrect Valve Placement Corrado Tamburino 161

164 transcatheter cardiovascular therapeutics twenty-fifth AnniversAry Save the date Oct 28-NOv 1, 2013 SaN FraNciScO the MOScONe center

165 Tuesday Breakfast Meetings Presentation Theater Programs Evening Programs Wednesday Breakfast Meetings Presentation Theater Programs Evening Programs Thursday Breakfast Meetings Presentation Theater Programs Evening Programs Friday Breakfast Meetings October 23-26, 2012 Miami Beach Convention Center miami, FL Satellites The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics

166 Satellite Symposia Tuesday, October 23 Breakfast Meetings Contemporary CTO PCI: BridgePoint Medical and the Hybrid Approach Miami Beach Convention Center, C Sponsored by BridgePoint Medical Chairs J. Aaron Grantham, MD University of Missouri Kansas City and Mid America Heart Institute Kansas City, MO Craig A. Thompson, MD, MMSc Yale New Haven Hospital New Haven, CT faculty Dimitri Karmpaliotis, MD Piedmont Heart Institute Atlanta, GA James Spratt, BSc, MD Forth Valley Royal Hospital Larbert, United Kingdom Simon Walsh, MD, MRCP Belfast Trust Belfast, United Kingdom Agenda 6:30 am - Breakfast 7:00 am - Hybrid Algorithm: US and EU Training/Proctoring Experience J. Aaron Grantham 7:15 am - Angiographic Evaluation and Procedural Approach Dimitri Karmpaliotis 7:30 am - BridgePoint Case Presentation 1 Simon Walsh 7:40 am - BridgePoint Case Presentation 2 James Spratt 7:50 am - Wrap-up Discussion with Q&A 8:00 am - Adjourn Innovative Hybrid Therapy for Complex Cardiovascular Problems: Collaborative Care Case Reviews Miami Beach Convention Center, D Sponsored by Cardiovascular Research Foundation Supported through an educational grant from Medtronic CardioVascular Chairs Susheel Kodali, MD NewYork-Presbyterian Hospital/ Columbia University Medical Center Mathew Williams, MD NewYork-Presbyterian Hospital/ Columbia University Medical Center faculty Harit Desai, MD DEBORAH Heart and Lung Center Browns Mills, NJ Jeffrey Lee, MD University of Maryland Baltimore, MD Gustavo Olivotti, MD Beneficencia Portuguesa de São Paulo São Paulo, Brazil Carlos Sada, MD Beneficencia Portuguesa de São Paulo São Paulo, Brazil Mukta Srivastava, MD University of Maryland Medical Center Baltimore, MD Ulrich Uluft, MD DEBORAH Heart and Lung Center Browns Mills, NJ Agenda 6:30 am - Breakfast 7:00 am - Welcome and Introductions Mathew Williams 7:03 am - Rare Evidence of Extrinsic Dynamic Compression in the Middle Third-Distal Left Anterior Descending Artery by Cartilaginous Part of the Penultimate Left Rib Arc Gustavo Olivotti, Carlos Sada 7:18 am - Discussion with Q&A 7:22 am - Hybrid Coronary Intervention Mukta Srivastava 7:37 am - Discussion with Q&A 7:41 am - Mitral Perivalvular Leak Repair via Transapical Approach Harit Desai, Ulrich Uluft 7:56 am - Discussion with Q&A 8:00 am - Adjourn Incorporating the Treatment of Chronic Venous Insufficiency into Your Practice Miami Beach Convention Center, D Sponsored by Covidien Chair William A. Gray, MD NewYork-Presbyterian Hospital/ Columbia University Medical Center faculty Jose I. Almeida, MD Miami Vein Center Miami, FL Michelle Sloan, APN Eastlake Cardiovascular St. Clair Shores, MI Agenda 6:30 am - Breakfast 7:00 am - Welcome William A. Gray 7:05 am - Disease State and Prevalence of Chronic Venous Insufficiency William A. Gray 7:20 am - CVI Treatment with Radiofrequency: Getting Started in Treating Veins Jose I. Almeida 7:35 am - Practice Development Techniques Michelle Sloan 7:50 am - Discussion with Q&A 8:00 am - Adjourn Rethinking EVAR: Disruptive Technologies for Aortic Interventions Miami Beach Convention Center, D Sponsored by Endologix, Inc. Chair Gary M. Ansel, MD MidOhio Cardiology and Vascular Columbus, OH faculty Edward B. Diethrich, MD Arizona Heart Foundation Phoenix, AZ Barry T. Katzen, MD Baptist Cardiac and Vascular Institute Miami, FL Zvonimir Krajcer, MD Texas Heart Institute Houston, TX 164

167 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics Agenda 6:30 am - Breakfast 7:00 am - Welcome and Introductions 7:05 am - Unresolved Challenges in AAA Repair Gary M. Ansel 7:15 am - Ventana Fenestrated System: Expanding the Number of Patients Eligible for EVAR Edward B. Diethrich 7:25 am - The Next Frontier in EVAR: Percutaneous Access and Closure Zvonimir Krajcer 7:35 am - From EVAR to EVAS: Revolutionary Polymer Sealing Technology Barry T. Katzen 7:45 am - Discussion with Q&A 8:00 am - Adjourn Tryton Growing Clinical Data Displacing Provisional Stenting? Miami Beach Convention Center, C Sponsored by Tryton Medical, Inc. Chairs Martin B. Leon, MD NewYork-Presbyterian Hospital/ Columbia University Medical Center Patrick W. Serruys, MD, PhD Thoraxcenter Rotterdam, The Netherlands faculty D. Christopher Metzger, MD Wellmont CVA Heart Institute Kingsport, TN David G. Rizik, MD Scottsdale Heart Group Scottsdale, AZ Giuseppe Tarantini, MD, PhD University of Padova Padova, Italy Mladen Vidovich, MD University of Illinois at Chicago Medical Center Chicago, IL Joanna Wykrzykowska, MD, PhD Amsterdam Medical Center Amsterdam, The Netherlands Agenda 6:30 am - Breakfast 7:00 am - The Tryton Pivotal IDE Study: Overview, Update, and Next Steps Martin B. Leon 7:10 am - Tryton Pooled Analysis Shows Excellent TVF Rates Compared with Historical Data Joanna Wykrzykowska 7:20 am - Case Presentations Moderators: D. Christopher Metzger, David G. Rizik, Giuseppe Tarantini, Mladen Vidovich 7:50 am - Discussion and Key Messages Patrick W. Serruys 8:00 am - Adjourn Expanding Your Interventional Practice with Peripheral Procedures Miami Beach Convention Center, D Sponsored by Volcano Corporation faculty Julian Javier, MD Physicians Regional Naples, FL Prakash Krishnan, MD Mount Sinai Medical Center Greg Mishkel, MD St. John s Hospital Springfield, IL Agenda 6:30 am - Breakfast 7:00 am - What Does It Take to Overcome the Obstacles and Establish a Successful and Growing EVAR and TEVAR Practice Greg Mishkel 7:15 am - Cardiologists and Veins: Why? Julian Javier 7:30 am - How to Build a Peripheral Vascular Disease Practice Prakash Krishnan 7:45 am - Adjourn Presentation Theater Programs LEVANT I: 24-Month Data and Lutonix Drug-Coated Balloon Miami Beach Convention Center, Presentation Theater 1 Sponsored by Bard Peripheral Vascular/Lutonix Chair Dierk Scheinert, MD Park-Krankenhaus Leipzig Leipzig, Germany Agenda 12:15 pm - The LEVANT I 24-Month Data Dierk Scheinert 1:15 pm - Adjourn SYMPLICITY HTN-3 Trial: Evaluating Renal Denervation for Treatment-Resistant Hypertension Miami Beach Convention Center, Presentation Theater 3 Sponsored by Medtronic, Inc. Chairs George L. Bakris, MD, DMSc University of Chicago Pritzker School of Medicine Chicago, IL David E. Kandzari, MD Piedmont Heart Institute Atlanta, GA faculty Murray D. Esler, MB, BS, PhD Baker IDI Heart and Diabetes Institute Melbourne, Australia Krishna Rocha-Singh, MD Prairie Heart Institute, St. John s Hospital Springfield, IL Agenda 12:15 pm - Introduction George L. Bakris 12:20 pm - Resistant Hypertension: The Prevalence and Burden George L. Bakris 12:30 pm - Introduction to Renal Denervation and Sympathetic Nervous System Murray D. Esler 12:45 pm - SYMPLICITY Clinical Trial Program Krishna Rocha-Singh 1:00 pm - SYMPLICITY HTN-3 Trial Design and Current Status David E. Kandzari 1:10 pm - Discussion with Q&A David E. Kandzari 1:15 pm - Adjourn Satellite Symposia - October 23-26, 2012

168 F O U N D AT I O N F O U N D AT I O N Satellite Symposia 166 Evolving Antiplatelet Strategies for ACS: An Evidence-Based Expert Panel Debate Miami Beach Convention Center, Presentation Theater 2 Sponsored by North American Center for Continuing Medical Education Supported through an educational grant from AstraZeneca This activity has been approved for 1 AMA PRA Category 1 Credit Chair Deepak L. Bhatt, MD, MPH VA Boston Healthcare System and Brigham and Women s Hospital Boston, MA faculty David J. Cohen, MD, MSc Saint Luke s Mid America Heart Institute Kansas City, MO E. Magnus Ohman, MD Duke University Medical Center Durham, NC Philippe Gabriel Steg, MD Groupe Hospitalier Bichat - Claude Bernard Paris, France Agenda 12:15 pm - What Is Your Periprocedural Antiplatelet Strategy for ACS Patients Undergoing PCI? David J. Cohen, E. Magnus Ohman, Philippe Gabriel Steg Moderator: Deepak L. Bhatt 12:30 pm - What Is Your Interpretation of Recent Guidelines and Clinical Data on Available Antiplatelets? David J. Cohen, E. Magnus Ohman, Philippe Gabriel Steg Moderator: Deepak L. Bhatt 12:45 pm - What Considerations Are Factored into Your Postprocedural Antiplatelet Strategy for Patients Who Have Undergone PCI? David J. Cohen, E. Magnus Ohman, Philippe Gabriel Steg Moderator: Deepak L. Bhatt 1:00 pm - What Is Your Position on the Value of Platelet Reactivity Testing in the Interventional Setting? David J. Cohen, E. Magnus Ohman, Philippe Gabriel Steg Moderator: Deepak L. Bhatt 1:15 pm - Adjourn Evening Programs C A R D I O VA S C U L A R R E S E A R C H Issues with DAPT: A Case-Based Roundtable with Experts The Perry South Beach Hotel, Ballroom Sponsored by Cardiovascular Research Foundation Supported through educational grants from Abbott Vascular and Boston Scientific Corporation This activity has been approved for 1.5 AMA PRA Category 1 Credits Chairs Roxana Mehran, MD Mount Sinai Medical Center Stephan Windecker, MD Swiss Cardiovascular Center Bern Bern, Switzerland faculty Fausto Feres, MD Instituto Dante Pazzanese de Cardiologia São Paulo, Brazil Philippe Généreux, MD NewYork-Presbyterian Hospital/ Columbia University Medical Center Ajay J. Kirtane, MD, SM NewYork-Presbyterian Hospital/ Columbia University Medical Center Laura Mauri, MD, MSc Brigham and Women s Hospital Boston, MA Tullio Palmerini, MD Dipartimento Cardiovascolare, Policlinico S. Orsola Bologna, Italy Daniel I. Simon, MD University Hospitals, Case Medical Center Cleveland, OH Agenda 6:30 pm - Dinner Reception 7:00 pm - Welcome, Introductions, and Session Goals Stephan Windecker 7:05 pm - A Mini-Review of the Latest ACC, AHA, and ESC Guidelines on DAPT and PCI Stephan Windecker Real-World Cases 7:15 pm - Case 1: Patient with STEMI and DES Tullio Palmerini Moderator: Stephan Windecker Discussants: Fausto Feres, Laura Mauri, Daniel I. Simon 7:20 pm - Panel and Synthesis 7:27 pm - Case 2: Patient Post-DES Requiring Noncardiac Surgery Ajay J. Kirtane Moderator: Stephan Windecker Discussants: Fausto Feres, Laura Mauri, Daniel I. Simon 7:32 pm - Panel and Synthesis 7:39 pm - Case 3: A Bleeding Patient Post-DES TBA 7:44 pm - Panel and Synthesis 7:51 pm - Case IV: Patient with Atrial Fibrillation and DES Daniel I. Simon 7:56 pm - Panel and Synthesis Review of Current Data on DAPT Duration with Next Generation DES 8:01 pm - EES: SPIRIT and More Philippe Généreux Moderator: Roxana Mehran 8:06 pm - RESOLUTE: The Latest Data Laura Mauri Moderator: Roxana Mehran 8:11 pm - Endeavor: PROTECT, OPTIMIZE Fausto Feres Moderator: Roxana Mehran 8:16 pm - BES: Leaders Program Stephan Windecker Moderator: Roxana Mehran 8:21 pm - Synthesis: Final Words and Take Home Messages 8:30 pm - Adjourn C A R D I O VA S C U L A R R E S E A R C H The Challenge of Coronary Calcification: From Yesterday to Tomorrow Ritz Carlton South Beach Hotel, Salon 1-2 Sponsored by Cardiovascular Research Foundation Supported through an educational grant from Cardiovascular Systems, Inc. This activity has been approved for 1.75 AMA PRA Category 1 Credits Chairs Gary S. Mintz, MD Cardiovascular Research Foundation Washington, DC

169 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics Gregg W. Stone, MD NewYork-Presbyterian Hospital/ Columbia University Medical Center faculty David C. Auth, PhD, NAE University of Washington Seattle, WA Maurice Buchbinder, MD Foundation for Cardiovascular Medicine San Diego, CA Jeffrey Chambers, MD Metropolitan Heart and Vascular Institute Minneapolis, MN Philippe Généreux, MD NewYork-Presbyterian Hospital/ Columbia University Medical Center Mark Reisman, MD Swedish Heart and Vascular Institute Seattle, WA Gert Richardt, MD, PhD Segeberger Kliniken Bad Segeberg, Germany Richard A. Shlofmitz, MD St. Francis Hospital Roslyn, NY Agenda 6:30 pm - Dinner Reception 7:00 pm - Prevalence and Impact of Coronary Calcification: Insights from Intravascular Imaging Gary S. Mintz 7:10 pm - Impact of Coronary Calcification in the DES Era: Problem Solved? Philippe Généreux 7:22 pm - Featured Lecture: PTCA and Rotational Atherectomy for Calcified Lesions: A No-Holds-Barred Historical Perspective David C. Auth 7:37 pm - Lessons Learned from Rotational Atherectomy in Heavily Calcified Lesions Mark Reisman 7:49 pm - Case 1: Complex Rotational Atherectomy: What I Learned the Hard Way Maurice Buchbinder 7:59 pm - ROTAXUS Revisited: Results, Implications, and Future Directions for Plaque Decalcification Gert Richardt 8:21 pm - Case 2: Orbital Atherectomy Vignettes Richard A. Shlofmitz 8:31 pm - Discussion and Closing Comments 8:45 pm - Adjourn Vascular Restoration: The Bioabsorbable DESolve Scaffold Platform Loews Miami Beach Hotel, Americana Ballroom-Salon 4 Sponsored by Elixir Medical Corporation Chair Martin B. Leon, MD New York-Presbyterian Hospital/ Columbia University Medical Center faculty John A. Ormiston, MB, ChB Mercy and Auckland City Hospitals Auckland, New Zealand Joachim Schofer, MD Hamburg University Cardiovascular Center Hamburg, Germany Stefan Verheye, MD, PhD Antwerp Cardiovascular Institute, ZNA Middleheim Hospital Antwerp, Belgium Bernard Witzenbichler, MD Charité University of Medicine Berlin Berlin, Germany Agenda 6:30 pm - Dinner Reception 7:00 pm - Elixir Medical Program Overview Martin B. Leon 7:12 pm - DESyne Clinical Data Bernard Witzenbichler 7:24 pm - DESyne BD Clinical Data Joachim Schofer 7:36 pm - DESolve Scaffold Preclinical Testing John A. Ormiston 7:48 pm - DESolve Scaffold Clinical Data Stefan Verheye 8:00 pm - Discussion 8:20 pm - Closing Remarks Martin B. Leon 8:30 pm - Adjourn High-Risk ACS: Overcoming the Limitations of Current Anticoagulant Therapy Dialogue with the Experts Loews Miami Beach Hotel, Americana Ballroom-Salon 1-2 Jointly sponsored by Beth Israel Medical Center and St. Luke s and Roosevelt Hospitals and Health Education Alliance, Inc. This CME activity is supported by an educational grant from sanofi-aventis U.S. Inc., A SANOFI COMPANY This activity has been approved for 1.5 AMA PRA Category 1 Credits Chair Deepak L. Bhatt, MD, MPH VA Boston Healthcare System and Brigham and Women s Hospital Boston, MA faculty Roxana Mehran, MD Mount Sinai School of Medicine Philippe Gabriel Steg, MD Groupe Hospitalier Bichat - Claude Bernard Paris, France Agenda 6:30 pm - Dinner Reception 7:00 pm - The Evolving Landscape of Anticoagulation in High-Risk ACS: Where Are We and Where Are We Going? Deepak L. Bhatt Discussants: Roxana Mehran, Philippe Gabriel Steg 7:30 pm - The Balance Between Ischemic Events and Bleeding: Can It Be Optimized? Roxana Mehran Discussants: Deepak L. Bhatt, Philippe Gabriel Steg 8:00 pm - Novel Anticoagulants: Exploring the Data to Reveal the Promise Philippe Gabriel Steg Discussants: Deepak L. Bhatt, Roxana Mehran 8:30 pm - Adjourn Twenty Years of FFR: From Experimental Index to Standard of Care Loews Miami Beach Hotel, Poinciana Ballroom Sponsored by St. Jude Medical Satellite Symposia - October 23-26, :09 pm - Orbital Atherectomy: Technology Description, Technique, and the ORBIT Studies Jeffrey Chambers Chair Morton J. Kern, MD University of California, Irvine Irvine, CA 167

170 F O U N D AT I O N Satellite Symposia Faculty Bernard De Bruyne, MD, PhD Cardiovascular Center Aalst Aalst, Belgium William F. Fearon, MD Stanford University Medical Center Stanford, CA Nico H.J. Pijls, MD, PhD Catharina Hospital Eindhoven, The Netherlands Peter N. Ver Lee, MD Eastern Maine Medical Center Bangor, ME Agenda 6:30 pm - Dinner Reception 7:00 pm - Course Welcome, Overview, Objectives Morton J. Kern 7:05 pm - Discovery, Evolution, and Validation of FFR Nico H.J. Pijls 7:30 pm - From Intermediate Lesions to Complex Coronary Disease Bernard De Bruyne 7:45 pm - FFR and Clinical Outcomes: DEFER, FAME, FAME II, and More William F. Fearon 8:00 pm - FFR in Everyday Use Peter N. Ver Lee 8:10 pm - What Makes FFR Unique? Did We Make Gruentzig s Dream Come Alive? Morton J. Kern 8:20 pm - Closing Comments Morton J. Kern 8:30 pm - Adjourn Wednesday, October 24 Breakfast Meetings Evolution of the AngioSculpt Technology: Preliminary Clinical Results with a Drug-Coated Scoring Balloon and a Valvuloplasty Device Miami Beach Convention Center, D Sponsored by AngioScore Chair Martin B. Leon, MD NewYork-Presbyterian Hospital/ Columbia University Medical Center faculty Ronald K. Binder, MD St. Paul s Hospital/University of British Columbia Vancouver, Canada Gary Gershony, MD John Muir Cardiovascular Institute Piedmont, CA Bruno Scheller, MD Universität des Saarlandes Homburg, Germany Patrick L. Whitlow, MD Cleveland Clinic Foundation Cleveland, OH Agenda 6:30 am - Breakfast 7:00 am - Welcome and Opening Remarks Martin B. Leon 7:03 am - Evolution of the AngioSculpt Technology Platform for Coronary and Peripheral Vascular Disease: Next Generation Devices Martin B. Leon 7:15 am - Role of the AngioSculpt Device in Complex Coronary Lesions and Bifurcations Patrick L. Whitlow 7:25 am - Early Results from PATENT-C: A Randomized FIM Trial Evaluating a Drug-Coated AngioSculpt Scoring Balloon in Coronary ISR Bruno Scheller 7:35 am - Early Clinical Experience with a Valvuloplasty Scoring Balloon in the Treatment of Critical Aortic Valve Stenosis Ronald K. Binder 7:45 am - Panel Discussion Ronald K. Binder, Martin B. Leon, Bruno Scheller, Patrick L. Whitlow 7:55 am - Closing Remarks Gary Gershony 8:00 am - Adjourn C A R D I O VA S C U L A R R E S E A R C H Hemodynamics: There s an App for That! Session I. Basic Concepts and Understanding Medical Management of Critical Patients Miami Beach Convention Center, C Sponsored by Cardiovascular Research Foundation Supported through an educational grant from ABIOMED, Inc. This activity has been approved for 1 AMA PRA Category 1 Credit Chair John M. Lasala, MD, PhD Washington University School of Medicine St. Louis, MO faculty Mark B. Anderson, MD Albert Einstein Healthcare Network Philadelphia, PA Daniel Burkhoff, MD, PhD Columbia University Agenda 6:30 am - Breakfast 7:00 am - Welcome and Overview John M. Lasala 7:05 am - Lecture Daniel Burkhoff 7:35 am - Case Presentation John M. Lasala 7:40 am - Case Discussion Mark B. Anderson, Daniel Burkhoff, John A. Lasala 8:00 am - Adjourn Expand Your Access Options: Retrograde Tibiopedal Access for Treatment of Total Occlusions Miami Beach Convention Center, D Sponsored by Cook Medical faculty Yazan Khatib, MD First Coast Cardiovascular Institute Jacksonville, FL Jihad A. Mustapha, MD Metro Health Heart and Vascular Grand Rapids, MI Aravinda Nanjundappa, MD West Virginia University Charleston, WV 168

171 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics Agenda 6:30 am - Breakfast 7:00 am - Retrograde Tibiopedal Access: How to Cross Lesions You Thought You Couldn t Yazan Khatib 7:15 am - The Angiosome Approach to Tibiopedal Access Jihad A. Mustapha 7:30 am - Choosing the Right Imaging Modality for Tibiopedal Access Aravinda Nanjundappa 7:45 am - Questions and Answers 8:00 am - Adjourn The Next Generation of Intervention: Renal Denervation, Lower Limb Revascularization, and Stroke Treatment Miami Beach Convention Center, D Sponsored by Covidien Chair William A. Gray, MD NewYork-Presbyterian Hospital/ Columbia University Medical Center faculty L. Nelson Hopkins, MD Buffalo General Medical Center Buffalo, NY John R. Laird Jr, MD UC Davis Medical Center Sacramento, CA John A. Ormiston, MB, ChB Mercy and Auckland City Hospitals Auckland, New Zealand Agenda 6:30 am - Breakfast 7:00 am - Welcome and Opening Remarks William A. Gray 7:05 am - Renal Denervation: Evidence for Resistant Hypertension and Perspectives on Current Technologies John A. Ormiston 7:19 am - The Data Delivered for Lower Limb Revascularization: Directional Atherectomy and CTO Options John R. Laird Jr 7:33 am - Stroke Treatment: The Next Generation L. Nelson Hopkins 7:47 am - Discussion with Q&A 8:00 am - Adjourn Provisional Treatment Approach of a Medina Bifurcation Lesion: When and How to Treat the Side Branch? Miami Beach Convention Center, D Sponsored by Minvasys Chair Roxana Mehran, MD Mount Sinai School of Medicine faculty Jacques Berland, MD Clinique Saint Hilaire Rouen, France Bruno Gracia del Blanco, MD Val d Hebron Hospital Barcelona, Spain Antoine Lafont, MD Hospital European Georges Pompidou Paris, France Marco A. Perin, MD, PhD Hospital Albert Einstein São Paulo, Brazil Agenda 6:30 am - Breakfast 7:00 am - Introduction Roxana Mehran 7:05 am - Provisional Approach with the Nile PAX and My Strategy for the Side Branch Bruno Gracia del Blanco 7:30 am - Provisional Approach with the Nile PAX and My Strategy for the Side Branch Jacques Berland 7:55 am - Conclusion and Take-home Messages Roxana Mehran 8:00 am - Adjourn The Science of Left Atrial Appendage Closure: Clinical Experience of the LARIAT Suture Delivery Device Miami Beach Convention Center, D Sponsored by SentreHEART, Inc. Chair William W. O Neill, MD University of Miami Miami, FL faculty Matthew J. Price, MD Scripps Green Hospital La Jolla, CA Ramon Quesada, MD Baptist Cardiac and Vascular Institute of Miami Miami, FL Miguel Valderrábano, MD, FACC The Methodist Hospital Houston, TX Agenda 6:30 am - Breakfast 7:00 am - Evolution of LAA Closure: The Innovation of Tradition William W. O Neill 7:10 am - Overview of LARIAT Clinical Data Matthew J. Price 7:20 am - The Electrophysiologist s Perspective Miguel Valderrábano 7:30 am - Lessons Learned from the Baptist Experience Ramon Quesada 7:40 am - Moderated Q&A Moderator: William W. O Neill Discussants: Matthew J. Price, Ramon Quesada, Miguel Valderrábano 8:00 am - Adjourn OCT to Guide Daily PCI Decision Making Miami Beach Convention Center, C Sponsored by St. Jude Medical Chair Steven P. Marso, MD Saint Luke s Health System Kansas City, MO faculty Jagat Narula, MD, PhD Mount Sinai School of Medicine Francisco Prati, MD San Giovanni Hospital Rome, Italy Agenda 6:30 am - Breakfast 7:00 am - Welcome and Course Objectives Steven P. Marso 7:05 am - Angiography Alone vs. Angiography and OCT to Guide Decision Making During PCI: The CLI-OPCI Study Francisco Prati 7:20 am - PCI Optimization Using Optical Coherence Tomography: A Representative Case Example Steven P. Marso 7:35 am - OCT Assessment of Plaque Erosion and Use to Guide Treatment Strategy in the AMI Patient Jagat Narula 7:50 am - Question and Answer Steven P. Marso, Jagat Narula, Francisco Prati Satellite Symposia - October 23-26, :00 am - Adjourn 169

172 Satellite Symposia Radial Access PCI: A Positive Economic Impact! Miami Beach Convention Center, C Sponsored by Terumo Interventional Systems Chair Adhir Shroff, MD, MPH University of Illinois Hospital and Health Sciences System Chicago, IL faculty Daniel H. Steinberg, MD Medical University of South Carolina Charleston, SC David Wohns, MD, FACC, FSCAI West Michigan Heart Grand Rapids, MI Agenda 6:30 am - Breakfast 7:00 am - Radial Access PCI: Clinical Impact and Cath Lab Economics Adhir Shroff 7:15 am - Radial Access PCI Economics in a Teaching Institute Daniel H. Steinberg 7:30 am - Radial vs. Femoral: Economic and Clinical Data from a Large Tertiary Care Facility David Wohns 7:45 am - Discussion with Q&A 8:00 am - Adjourn The Crucial Role of FFR in the Post- SYNTAX Era Miami Beach Convention Center, C Sponsored by Volcano Corporation Chair Morton J. Kern, MD University of California, Irvine Irvine, CA faculty Justin E. Davies, MBBS, MRCP, PhD Imperial College London Trust London, United Kingdom Agenda 6:30 am - Breakfast 7:00 am - How FFR Makes Complex PCI Less Complex: The Importance of a Functional SYNTAX Score 7:25 am - Simplifying Decisions in Serial Lesions 7:40 am - A Glimpse into the Future of MVD with New Wire Technology and ifr Functionality 8:00 am - Adjourn Presentation Theater Programs How Should I Treat Hemodynamically Unstable Patients Undergoing PCI? Miami Beach Convention Center, Presentation Theater 3 Sponsored by MAQUET Cardiovascular Chair Simon Redwood, MD St. Thomas Hospital London, United Kingdom faculty Henry Cusnir, MD Florida Medical Center Fort Lauderdale, FL Navin K. Kapur, MD Tufts Medical Center Boston, MA Atman P. Shah, MD The University of Chicago Hospital Chicago, IL Holger Thiele, MD University of Leipzig Heart Center Leipzig, Germany Agenda 10:00 am - Introduction Simon Redwood 10:05 am - Complex Case Presentation 1 Henry Cusnir 10:10 am - Case Review Navin K. Kapur 10:20 am - How Did I Treat? Henry Cusnir 10:25 am - Discussion 10:30 am - Complex Case Presentation 2 Atman P. Shah 10:35 am - Case Review Holger Thiele 10:45 am - How Did I Treat? Atman P. Shah 10:50 am - Discussion Henry Cusnir, Navin K. Kapur, Simon Redwood, Atman P. Shah, Holger Thiele 10:55 am - Take-home Messages Simon Redwood 11:00 am - Adjourn Interventional Cardiovascular Medicine in Asia: Current Approaches and Challenges Miami Beach Convention Center, Presentation Theater 1 Sponsored by Medtronic CardioVascular Chairs Fang Chen, MD Beijing Anzhen Hospital Beijing, China Ian T. Meredith, MBBS, PhD Monash Medical Centre Clayton Melbourne, Australia faculty Chi-Hung Huang, MD Cathay General Hospital Taipei, Taiwan Yang-Soo Jang, PhD Yonsei University Health System Seoul, South Korea Michael K. Lee, MD, MBBS Queen Elizabeth Hospital Kowloon, China J. Shiv Kumar Rao, MBBS, MD Apollo Hospital Secunderabad, India Mohd Ali Rosli, MD National Heart Institute Kuala Lumpur, Malaysia Ajay R. Sinhal, MBBS, MD, DM Flinders Medical Centre Adelaide, Australia Huay Cheem Tan, MD National University Heart Centre Singapore, Malaysia Masahisa Yamane, MD Sayama Hospital Sayama City, Japan Agenda 12:15 pm - Objectives and Introduction Moderator: Ian T. Meredith 12:19 pm - Complex PCI in a Diabetic Patient J. Shiv Kumar Rao 12:22 pm - How Would I Treat Masahisa Yamane 12:25 pm - How Would I Treat Chi-Hung Huang 170

173 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics 12:28 pm - How Did I Treat J. Shiv Kumar Rao 12:33 pm - Discussion Moderator: Ian T. Meredith 12:35 pm - Consensus Moderator: Ian T. Meredith 12:36 pm - Structural Heart Case Presentation Mohad Ali Rosli 12:39 pm - How Would I Treat Ajay R. Sinhal 12:42 pm - How Would I Treat Ian T. Meredith 12:45 pm - How Did I Treat Mohad Ali Rosli 12:50 pm - Discussion Moderator: Ian T. Meredith 12:52 pm - Consensus Moderator: Ian T. Meredith 12:53 pm - Complex Case Presentation: Resistent Hypertension Michael K. Lee 12:56 pm - How Would I Treat Huay Cheem Tan 12:59 pm - How Would I Treat Yang-Soo Jang 1:02 pm - How Did I Treat Michael K. Lee 1:07 pm - Discussion Moderator: Ian T. Meredith 1:09 pm - Consensus Moderator: Ian T. Meredith 1:10 pm - Take-home Message Moderator: Fang Chen 1:15 pm - Adjourn New Frontiers in Interventional Cardiology: A Luncheon Symposium with Experts Miami Beach Convention Center, Presentation Theater 3 Sponsored by Meril Life Sciences Pvt. Ltd. Chair Upendra Kaul, MD, PhD Fortis Escorts Hospital New Delhi, India faculty Pawel E. Buszman, MD, PhD American Heart of Poland Katowice, Poland Karl-Heinz Kuck, MD, PhD Asklepios Hospital St. Georg Hamburg, Germany Roberto Botelho, MD, PhD Triangulo Heart Institute Uberlandia, Brazil Ali Faizal, MD, DM Malabar Institute of Medical Science Calicut, India M.S. Hiremath, MD, DM, MNAMS Ruby Hall Clinic Pune, India Zaza Kavteladze, MD The Centre of Endosurgery and Lithotripsy Moscow, Russia Martin B. Leon, MD NewYork-Presbyterian Hospital/ Columbia University Medical Center C.N. Manjunath, MD, DM Sri Jayadeva Institute of Cardiovascular Sciences and Research Bangalore, India Christoph K. Naber, MD, PhD Contilia Heart and Vascular Center Essen, Germany Teguh Santoso, MD, FACC, FESC Medistra Hospital, Indonesia Jakarta, Indonesia Ashok Seth, DSc Escorts Heart Institute and Research Centre New Delhi, India Adam Witkowski, MD, PhD Institute of Cardiology Warsaw, Poland Agenda 12:15 pm - Next Generation of Stent Designs: NexGen and the Polish ACS Experience Pawel E. Buszman 12:23 pm - BioMimicry in DES: BioMime and merit Clinical Update Ashok Seth 12:31 pm - The Evolving Interventional Landscape: Futuristic DES, Valves, and Beyond Martin B. Leon 12:41 pm - Leapfrogging to Bioresorbable Scaffolds: MeRes Christoph K. Naber 12:49 pm - BioMime Indian Experience M. S. Hiremath 12:57 pm - BioMime Brazil Experience Roberto Botelho 1:05 pm - Discussion 1:15 pm - Adjourn STENTYS IDE Trial in STEMI: The Self- Apposing Stent Revolution Is Coming to the United States Miami Beach Convention Center, Presentation Theater 2 Sponsored by STENTYS Chair Maurice Buchbinder, MD Foundation of Cardiovascular Medicine San Diego, CA faculty Donald Cutlip, MD Beth Israel Deaconess Medical Center Boston, MA Roxana Mehran, MD Mount Sinai School of Medicine Harald G. W. Mudra, MD, PhD Klinikum Neuperlach Munich, Austria Robert-Jan van Geuns, MD, PhD Erasmus Medical Center Rotterdam, The Netherlands Agenda 12:15 pm - Better Stent Sizing Leads to Better Outcomes: The Self-Apposing Stent Technology Maurice Buchbinder 12:25 pm - Real-world Use in 1000 STEMI Patients: APPOSITION III One-Year Interim Results Harald G. W. Mudra 12:45 pm - Routine Clinical Practice and Experience with a Self-Apposing Stent Robert-Jan van Geuns 1:00 pm - STENTYS Randomized IDE Trial in STEMI: The APPOSITION V Study in the United States and Worldwide Roxana Mehran 1:15 pm - Adjourn Evening Programs Emerging Technology and Trial Designs: Challenging Conventional Strategies Loews Miami Beach Hotel, Poinciana Ballroom Sponsored by Biosensors International Chairs Teguh Santoso, MD, PhD Medistra Hospital Jakarta, Indonesia Patrick W. Serruys, MD, PhD Thoraxcenter Rotterdam, The Netherlands Satellite Symposia - October 23-26,

174 F O U N D AT I O N Satellite Symposia Faculty Christoph K. Naber, MD, PhD Contilia Heart and Vascular Center Essen, Germany Gennaro Sardella, MD Policlinico Umberto I University Rome, Italy Philip M. Urban, MD Hôpital de la Tour Geneva, Switzerland Stephan Windecker, MD Swiss Cardiovascular Center Bern Bern, Switzerland Agenda 6:30 pm - Dinner Reception 7:00 pm - Introduction and Objectives Teguh Santoso 7:05 pm - Five Years Ahead: Final Report on LEADERS, the First All-Comers DES Trial Patrick W. Serruys 7:20 pm - Biolimus-Eluting Stents in STEMI Patients: Update from the COMFORTABLE AMI Trial Stephan Windecker 7:35 pm - Can Stent Design Impact the Treatment of Bifurcation Lesions? Gennaro Sardella 7:50 pm - Are Current DES the Final Answer? Christoph K. Naber 8:05 pm - DES, Bleeding Risk, and the Non-Comers Population Philip M. Urban Discussion 8:20 pm - Take-home Message Patrick W. Serruys 8:30 pm - Adjourn The Future of Stents, TAVR, Left Atrial Appendage Closure, and Renal Denervation: A Case-Based Review The Perry South Beach Hotel, Ballroom Sponsored by Boston Scientific Corporation Chairs Ted M. Feldman, MD Evanston Hospital Evanston, IL Jeffrey M. Moses, MD New York-Presbyterian Hospital/ Columbia University Medical Center faculty Maurice Buchbinder, MD Foundation for Cardiovascular Medicine San Diego, CA Dean Kereiakes, MD The Christ Hospital Cincinnati, OH Ian T. Meredith, MBBS, PhD Monash Medical Centre Clayton, Australia Krishna J. Rocha-Singh, MD Prairie Heart Institute, St. John s Hospital Springfield, IL Agenda 6:30 pm - Dinner Reception 7:00 pm - Welcome Ted M. Feldman, Jeffrey M. Moses 7:15 pm - Drug-Eluting Stent Advancements Dean Kereiakes 7:30 pm - Transcatheter Aortic Valve Replacement Ian T. Meredith 7:45 pm - Left Atrial Appendage Closure Maurice Buchbinder 8:00 pm - Renal Denervation for Resistant Hypertension Krishna J. Rocha-Singh 8:15 pm - Wrap Up Jeffrey M. Moses 8:30 pm - Adjourn C A R D I O VA S C U L A R R E S E A R C H TAVR 2012: A Year to Remember! Loews Miami Beach Hotel, Americana Ballroom-Salon 4 Sponsored by Cardiovascular Research Foundation Supported through an educational grant from Edwards Lifesciences This activity has been approved for 1.5 AMA PRA Category 1 Credits Chairs Martin B. Leon, MD NewYork-Presbyterian Hospital/ Columbia University Medical Center Martyn R. Thomas, MD St. Thomas Hospital London, United Kingdom faculty John D. Carroll, MD University of Colorado Denver, CO Raj Makkar, MD Cedars-Sinai Medical Center Los Angeles, CA Josep Rodés-Cabau, MD Québec Heart and Lung Institute/ Laval University Québec, Canada Wilson Y. Szeto, MD University of Pennsylvania Medical Center Philadelphia, PA Vinod H. Thourani, MD Emory University Hospital Midtown Atlanta, GA E. Murat Tuzcu, MD Cleveland Clinic Foundation Cleveland, OH Agenda 6:30 pm - Dinner Reception Section I 7:00 pm - New Clinical Research: The Year in Review Martin B. Leon 7:15 pm - Panel Discussion Section II 7:18 pm - New Techniques: Annulus Measurements and Alternative Access Sites Raj Makkar 7:33 pm - Panel Discussion Section III 7:36 pm - New Technology: Next- Generation Devices Josep Rodés-Cabau 7:51 pm - Panel Discussion Section IV 7:54 pm - New National Registry and Reimbursement John D. Carroll 8:09 pm - Panel Discussion Section V 8:12 pm - New TAVR Sites: A Roundtable Discussion with New TAVR Commercial Sites Vinod H. Thourani, E. Murat Tuzcu 8:30 pm - Adjourn 172

175 F O U N D AT I O N F O U N D AT I O N The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics C A R D I O VA S C U L A R R E S E A R C H Myth Busters: Is Complete Coronary Revascularization Really Essential? Loews Miami Beach Hotel, Americana Ballroom-Salon 3 Sponsored by Cardiovascular Research Foundation Supported through an educational grant from Gilead Sciences This activity has been approved for 1.5 AMA PRA Category 1 Credits Chairs Gregg W. Stone, MD NewYork-Presbyterian Hospital/ Columbia University Medical Center Giora Weisz, MD NewYork-Presbyterian Hospital/ Columbia University Medical Center faculty Michael Argenziano, MD NewYork-Presbyterian Hospital/ Columbia University Medical Center Bernard J. Gersh, MB, ChB, DPhil Mayo Clinic Rochester, MN Agenda 6:30 pm - Dinner Reception 7:00 pm - Introduction and Session Goals Giora Weisz 7:05 pm - The Positive and Negative Impact of Incomplete Revascularization After PCI Gregg W. Stone 7:20 pm - Discussion 7:25 pm - Incomplete Revascularization After Surgery: Knowns and Unknowns Bernard J. Gersh 7:40 pm - Discussion 7:45 pm - Pathways to Reduced Ischemia 1: Hybrid PCI-CABG Michael Argenziano 8:00 pm - Discussion 8:05 pm - Pathways to Reduced Ischemia 2: Adjuvant Pharmacotherapies Giora Weisz MGuard Embolic Protection Stent: A New Era in STEMI Treatment Ritz Carlton South Beach Hotel, Salon 1-2 Sponsored by InspireMD Chairs Sigmund Silber, MD Heart Center at the Isar Munich, Germany Gregg W. Stone, MD NewYork-Presbyterian Hospital/ Columbia University Medical Center faculty Antonio Colombo, MD Columbus Hospital/San Raffaele Hospital Milan, Italy Carlo Di Mario, MD Royal Brompton Hospital London, United Kingdom Dariusz Dudek, MD, PhD Jagiellonian University Krakow, Poland Eberhard Grube, MD University Hospital Bonn Bonn, Germany Martin B. Leon, MD NewYork-Presbyterian Hospital/ Columbia University Medical Center Chaim S. Lotan, MD Hadassah University Hospital Jerusalem, Israel Agenda 6:30 pm - Dinner Reception 7:00 pm - The Unmet Need in STEMI Sigmund Silber 7:10 pm - The MGuard Embolic Protection Stent Technology Chaim S. Lotan 7:20 pm - MGuard World Experience: What Did We Learn? Dariusz Dudek 7:35 pm - Challenging Cases 7:55 pm - Master Trial Design and Results Gregg W. Stone 8:15 pm - Conclusions and Takeaway Messages Martin B. Leon 8:30 pm - Adjourn Thursday, October 25 Breakfast Meetings C A R D I O VA S C U L A R R E S E A R C H Hemodynamics: There s an App for That! Session II. Understanding the Effects of Mechanical Support Devices Miami Beach Convention Center, C Sponsored by Cardiovascular Research Foundation Supported through an educational grant from ABIOMED, Inc. This activity has been approved for 1 AMA PRA Category 1 Credit Chair John M. Lasala, MD, PhD Washington University School of Medicine St. Louis, MO faculty Mark B. Anderson, MD Albert Einstein Healthcare Network Philadelphia, PA Daniel Burkhoff, MD, PhD Columbia University Morton J. Kern, MD University of California Irvine Irvine, CA Agenda 6:30 am - Breakfast 7:00 am - Welcome and Overview John M. Lasala 7:05 am - Lecture Daniel Burkhoff 7:35 am - Case Presentaiton Mark B. Anderson 7:45 am - Case Discussion Mark B. Anderson, Daniel Burkhoff, Morton J. Kern, John M. Lasala 8:00 am - Adjourn Satellite Symposia - October 23-26, :20 pm - Discussion 8:30 pm - Adjourn 173

176 F O U N D AT I O N Satellite Symposia C A R D I O VA S C U L A R R E S E A R C H Renal Denervation for Treatment-Resistant Hypertension: A Focused Update Miami Beach Convention Center, D Sponsored by Cardiovascular Research Foundation Supported through an educational grant from Medtronic CardioVascular This activity has been approved for 1 AMA PRA Category 1 Credit Chairs David E. Kandzari, MD Piedmont Heart Institute Atlanta, GA Ajay J. Kirtane, MD, SM NewYork-Presbyterian Hospital/ Columbia University Medical Center faculty Deepak L. Bhatt, MD, MPH VA Boston Healthcare System and Brigham and Women s Hospital Boston, MA Justin E. Davies, MBBS, MRCP, PhD Imperial College London NHS Trust London, United Kingdom Horst Sievert, MD, PhD CardioVascular Center Frankfurt, Sankt Katharinen Frankfurt, Germany Paul A. Sobotka, MD Hennepin County Medical Center Minneapolis, MN Agenda 6:30 am - Breakfast 7:00 am - A Primer on the Science Behind Renal Denervation Paul A. Sobotka 7:15 am - The Symplicity Clinical Trial Program Deepak L. Bhatt 7:30 am - Selected Case Studies Horst Sievert 7:45 am - Renal Denervation: Present/Future Applications Justin E. Davies 7:55 am - Discussion and Q&A 8:00 am - Adjourn Introducing Robotic-Assisted PCI into Your Daily Cath Lab Practice Miami Beach Convention Center, D Sponsored by Corindus Vascular Robotics and Philips Healthcare Chairs Peter J. Fitzgerald, MD, PhD Stanford University Medical Center Stanford, CA Giora Weisz, MD NewYork-Presbyterian Hospital/ Columbia University Medical Center faculty Joseph P. Carrozza Jr, MD Steward St. Elizabeth s Medical Center Boston, MA J. Jeffrey Marshall, MD Northeast Georgia Heart Center Gainesville, GA George W. Vetrovec, MD VCU Medical Center Richmond, VA Agenda 6:30 am - Breakfast 7:00 am - Opening Remarks Peter J. Fitzgerald 7:05 am - CorPath 200 System Overview: Robotic-Assisted PCI George W. Vetrovec 7:15 am - The PRECISE Trial Results Giora Weisz 7:25 am - A Day in a CorPath Lab: Treating Different Patients with a Robotic System J. Jeffrey Marshall 7:40 am - Robotics in the Cath Lab: Hospital s Perspective Joseph P. Carrozza Jr 7:50 am - Roundtable Discussion Moderator: Peter J. Fitzgerald Discussants: Joseph P. Carrozza Jr, J. Jeffrey Marshall, George W. Vetrovec, Giora Weisz 8:00 am - Adjourn Direct Flow Medical Transcatheter Aortic Valve System Miami Beach Convention Center, C Sponsored by Direct Flow Medical, Inc. Chairs Reginald I. Low, MD UC Davis Heart Center Sacramento, CA E. Murat Tuzcu, MD Cleveland Clinic Cleveland, OH faculty Antonio Colombo, MD Columbus Hospital/San Raffaele Hospital Milan, Italy Charles J. Davidson, MD Northwestern Memorial Hospital Chicago, IL Thierry Lefevre, MD Institut Hospitalier Jacques Cartier Massy, France William W. O Neill, MD Henry Ford Hospital Detroit, MI Joachim Schofer, MD Hamburg University Cardiovascular Center Hamburg, Germany Agenda 6:30 am - Breakfast 7:00 am - Introduction Reginald I. Low 7:05 am - Direct Flow Medical Transcatheter Aortic Valve: Technical Overview Charles J. Davidson 7:15 am - DISCOVER Trial Clinical Results Thierry Lefevre, Joachim Schofer 7:30 am - Improving Outcomes: Clinical Case Review of DFM Technology Antonio Colombo 7:45 am - Future Clinical Trials: Assessment and Implications of Aortic Regurgitation William W. O Neill 7:55 am - Questions and Answers E. Murat Tuzcu 8:00 am - Adjourn Titanium Nitride Oxide Bioactive Stent: The Evidence-Based Choice in Acute Coronary Syndrome Miami Beach Convention Center, D Sponsored by Hexacath SAS Chair Pasi Karjalainen, MD, PhD Satakunta Central Hospital Pori, Finland faculty Michaël Angioi, MD University Hospital Nancy Nancy, France Joan A. Gomez-Hospital, MD Bellvitge Hospital Universitari Barcelona, Spain 174

177 The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics Agenda 6:30 am - Breakfast 7:00 am - CATS-AMI Study New Insights Michaël Angioi 7:15 am - Discussion 7:20 am - TiTAN AMI Spanish Registry Joan A. Gomez-Hospital 7:35 am - Discussion 7:40 am - The BASE-ACS Study Follow-up Pasi Karjalainen 7:55 am - Discussion 8:00 am - Adjourn Imaging STEMI Culprit Plaques with Near IR Spectroscopy: Clinical Implications Miami Beach Convention Center, C Sponsored by InfraReDx, Inc. Chair James A. Goldstein, MD William Beaumont Hospital Royal Oak, MI faculty David Erlinge, MD, PhD Lund University Hospital Lund, Sweden Ryan D. Madder, MD Frederik Meijer Heart and Vascular Institute, Spectrum Health System Grand Rapids, MI Agenda 6:30 am - Breakfast 7:00 am - Introductions and Symposium Objectives James A. Goldstein 7:05 am - The NIRS Signature of STEMI Culprit Plaques Ryan D. Madder 7:20 am - Yellow Means Trouble: The Early Swedish Experience with TVC-Guided PCI David Erlinge 7:35 am - TVC-Guided PCI and Its Role in Your Interventional Practice James A. Goldstein 7:50 am - Discussion with Q&A 8:00 am - Adjourn OrbusNeich s COMBO Dual Therapy Stent : Addressing the Limitations of Drug-Eluting Stents Miami Beach Convention Center, C Sponsored by OrbusNeich Chairs Stephen W.L. Lee, MD Queen Mary Hospital Hong Kong, China Roxana Mehran, MD Mount Sinai School of Medicine faculty Michael Haude, MD Lukaskrankenhaus Neuss Neuss, Germany Jonathan M. Hill, MD, MRCP King s College Hospital London, United Kingdom Ulf Landmesser, MD, PhD University Hospital of Zurich Zurich, Switzerland Agenda 6:30 am - Breakfast 7:00 am - Addressing the Unmet Needs of Balancing Bleeding and Ischemic Events: A Real-world Daily Dilemma for the Practicing Cardiologist Roxana Mehran 7:10 am - COMBO Dual Therapy Stent Technology: The Results from the REMEDEE Study Michael Haude 7:25 am - Assessing EPC Capture Effects on Vascular Healing Jonathan M. Hill 7:35 am - Early Healing and Endothelial Response with COMBO Stent: REMEDEE OCT Study Design and Preliminary Results Ulf Landmesser 7:50 am - Focus on the Future: Discussion with Q&A Stephen W.L. Lee 8:00 am - Adjourn Strategies to Address Guidelines, Necessity and Improve PCI Outcomes Miami Beach Convention Center, D Sponsored by Volcano Corporation Jasvindar Singh, MD, FACC Washington University School of Medicine St. Louis, MO Bernard Witzenbichler, MD Charité University of Medicine Berlin Berlin, Germany Agenda 6:30 am - Breakfast 7:00 am - FFR-Guided PCI in Practice Today: Meeting Necessity and Quality Demands David G. Rizik 7:20 am - Intravascular Imaging in Complex PCIs: Improving Outcomes to Reduce Readmissions Jasvindar Singh 7:40 am - Translating the Newest ADAPT Data into Today s Routine Clinical Practice Bernard Witzenbichler 8:00 am - Adjourn Presentation Theater Programs Why Drug-Eluting SFA Stents Will Replace Bare Metal Stents Miami Beach Convention Center, Presentation Theater 1 Sponsored by Cook Medical Chair Gary M. Ansel, MD Riverside Methodist Hospital Columbus, OH faculty Mark W. Burket, MD University of Toledo Medical Center Toledo, OH Dierk Scheinert, MD Park-Krankenhaus Leipzig Leipzig, Germany Agenda 12:15 pm - Your Life on Drugs: Will We Ever Go Back to Bare Metal Stents in the SFA? Gary M. Ansel 12:30 pm - What Are the True Costs of Treating In-Stent Restenosis? Mark W. Burket 12:45 pm - How Drug-Eluting Stents Have Affected My Practice Dierk Scheinert Satellite Symposia - October 23-26, 2012 faculty David G. Rizik, MD Scottsdale Heart Group Scottsdale, AZ 1:00 pm - Discussion Discussants: Gary M. Ansel, Mark W. Burket, Dierk Scheinert 1:15 pm - Adjourn 175

178 F O U N D AT I O N Satellite Symposia Emerging Regions Interventional Cardiology Symposium: India Miami Beach Convention Center, Presentation Theater 2 Sponsored by India Medtronic Pvt. Ltd. Chairs A.B. Mehta, MD Jaslok Hospital and Research Centre Mumbai, India Vinay K. Bahl, MD, DM All India Institute of Medical Sciences New Delhi, India Manish A. Parikh, MD NewYork-Presbyterian Hospital/ Columbia University Medical Center faculty Thomas Alexander, MD KMCH Hospital Coimbatore, India Shirish Hiremath, MD Ruby Hall Clinic Pune, India Fazila T. Malik, MD NHFH and RI Dhaka, India Sundeep Mishra, MD, DM All India Institute of Medical Sciences New Delhi, India Keyur H. Parikh, MD Care Institute Medical Sciences Ahmedabad, India Ashok Seth, DSc Escorts Heart Institute and Research Centre New Delhi, India Nakul Sinha, MD Sahara Hospital Lucknow, India Agenda 12:15 pm - Introductions Fazila T. Malik, Nakul Sinha 12:18 pm - Opening Remarks A.B. Mehta, Vinay K. Bahl, Manish A. Parikh 12:20 pm - Emergence of Interventional Cardiology in India Sundeep Mishra 12:30 pm - Initiating Innovative Therapies Ashok Seth 12:40 pm - Resistant Hypertension: Patient Pathways to Treatment Keyur H. Parikh 12:50 pm - Making Complex Coronary Lesions Simple Shirish Hiremath 1:00 pm - Establishing a System of Care for STEMI Thomas Alexander 1:10 pm - Discussions A.B. Mehta, Manish A. Parikh 1:15 pm - Adjourn From Short Stay to Same Day: Optimizing Outpatient PCI Pathways Miami Beach Convention Center, Presentation Theater 3 Sponsored by The Medicines Company Chairs Harold L. Dauerman, MD Saint Luke s Mid America Heart Institute Kansas City, MO Sunil V. Rao, MD Duke University Medical Center Durham, NC faculty Ehtisham Mahmud, MD University of California San Diego, CA Duane S. Pinto, MD, MPH Beth Israel Deaconess Medical Center Boston, MA Agenda 12:15 pm - What Is the Rationale and the Expected Benefits of Early Discharge? Ehtisham Mahmud Moderator: Harold L. Dauerman 12:27 pm - What Are the Economic Implications? Duane S. Pinto Moderator: Harold L. Dauerman 12:39 pm - Is Same Day Discharge Safe? Harold L. Dauerman 12:51 pm - How to Organize the Clinical Pathway? Harold L. Dauerman 1:03 pm - Discussion Discussants: Harold L. Dauerman, Ehtisham Mahmud, Duane S. Pinto, Sunil V. Rao 1:15 pm - Adjourn Evening Programs C A R D I O VA S C U L A R R E S E A R C H Drug-Coated Balloon Technologies: Today and Tomorrow Loews Miami Beach Hotel, Americana Ballroom-Salon 3 Sponsored by Cardiovascular Research Foundation Supported through an educational grant from AngioScore, BIOTRONIK, Boston Scientific Corporation, Cook Medical, EuroCOR GmbH, Lutonix/Bard, Medtronic CardioVascular This activity has been approved for 1.5 AMA PRA Category 1 Credits Chairs Juan F. Granada, MD CRF Skirball Research Center Orangeburg, NY Bruno Scheller, MD Universitätsklinikum des Saarlandes Homburg, Germany faculty Antonio Colombo, MD Columbus Hospital/San Raffaele Hospital Milan, Italy Duane S. Pinto, MD, MPH Beth Israel Deaconess Medical Center Renu Virmani, MD CVPath Institute, Inc. Gaithersburg, MD Thomas Zeller, MD Herzzentrum Freiburg-Bad Krozingen Bad Krozingen, Germany Agenda 6:30 pm - Dinner Reception 7:00 pm - SFA and Below-the-Knee DCB Applications: Update on the Data and Competitive Technologies Thomas Zeller 7:10 pm - Coronary DCB Applications: Current Uses and Future Applications Antonio Colombo 7:20 pm - Discussion 7:30 pm - Experimental Evaluation of Device Success: Local Tissue Effects, Distal Embolization, and Beyond Renu Virmani 176

179 F O U N D AT I O N The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics 7:40 pm - Sirolimus Analogues and DCB Development: Emerging Concepts, Biological Considerations, and Technical Challenges Juan F. Granada 7:50 pm - Technological Challenges for DCB Development: Where Is Future Innovation Needed? Bruno Scheller 8:00 pm - Discussion 8:15 pm - Economic Issues in PAD: Implications for DCB Technology Duane S. Pinto 8:25 pm - Discussion 8:30 pm - Adjourn C A R D I O VA S C U L A R R E S E A R C H Knights of the Roundtable 2012: Defending and Challenging AMI Therapies Ritz Carlton South Beach Hotel, Salon 1-2 Sponsored by Cardiovascular Research Foundation Supported through an educational grant from AstraZeneca and through an independent grant from The Medicines Company This activity has been approved for 1.75 AMA PRA Category 1 Credits Chairs Cindy L. Grines, MD Detroit Medical Center Detroit, MI Ajay J. Kirtane, MD, SM NewYork-Presbyterian Hospital/ Columbia University Medical Center Gregg W. Stone, MD NewYork-Presbyterian Hospital/ Columbia University Medical Center faculty Dimitrios Alexopoulos, MD Patras University Hospital Patras, Greece Dominick J. Angiolillo, MD, PhD University of Florida-Shands Jacksonville, FL Laurent Bonello, MD Hôpital Universitaire Nord Marseille, France David A. Cox, MD Lehigh Valley Hospital Bethlehem, PA Nick Curzen, BM, PhD Southampton University Hospitals Southampton, United Kingdom Giuseppe De Luca, MD Eastern Piedmont University Novara, Italy Frederick Feit, MD New York University Medical Center Kishore J. Harjai, MD Guthrie Clinic Sayre, PA Jose P.S. Henriques, MD, PhD, MBA Academic Medical Center Amsterdam, The Netherlands Stefan K. James, MD Uppsala Clinical Research Center Uppsala, Sweden Sanjit S. Jolly, MD McMaster University Hamilton, Canada Michael R. Le May, MD University of Ottawa Heart Institute Ottawa, Canada Chaim S. Lotan, MD Hadassah University Hospital Jerusalem, Israel Massimo Napodano, MD Padova University Hospital Padova, Italy Holger Thiele, MD University of Leipzig Heart Center Leipzig, Germany Harvey D. White, DSc Green Lane Cardiovascular Service, Auckland City Hospital Auckland, New Zealand Bernhard Witzenbichler, MD Charité University of Medicine Berlin Berlin, Germany Stephen D. Wiviott, MD Brigham and Women s Hospital Boston, MA Jochen Wöhrle, MD University Hospital Ulm Ulm, Germany Agenda 6:30 pm - Dinner Reception Unsettled Issues in STEMI I. Prasugrel vs. Ticagrelor? 7:00 pm - The Case for Prasugrel Stephen D. Wiviott Moderator: Gregg W. Stone Discussants: Dimitrios Alexopoulos, Laurent Bonello, Frederick Feit, Harvey D. White 7:08 pm - The Case for Ticagrelor Stefan K. James Moderator: Gregg W. Stone Discussants: Dimitrios Alexopoulos, Laurent Bonello, Frederick Feit 7:16 pm - The Case for Cangrelor Dominick J. Angiolillo Moderator: Gregg W. Stone Discussants: Dimitrios Alexopoulos, Laurent Bonello, Frederick Feit 7:24 pm - The Case for Selective Use of Clopidogrel Nick Curzen Moderator: Gregg W. Stone Discussants: Dimitrios Alexopoulos, Laurent Bonello, Frederick Feit 7:32 pm - Discussion with Q&A Unsettled Issues in STEMI II. DES and Prasugrel Duration 7:44 pm - How Beneficial are Best-in-Class DES and Potent ADP Antagonists? Anticipating HORIZONS AMI II Gregg W. Stone Moderator: Cindy L. Grines Discussants: Giuseppe De Luca, Kishore J. Harjai, Michael R. Le May 7:54 pm - Discussion with Q&A Unsettled Issues in STEMI III. Dealing with Thrombus, I Prefer... 8:04 pm - Aspiration Thrombectomy Sanjit S. Jolly Moderator: Ajay J. Kirtane Discussants: David A. Cox, Jose P.S. Henriques, Massimo Napodano, Bernhard Witzenbichler 8:12 pm - Intracoronary Abciximab Jochen Wöhrle Moderator: Ajay J. Kirtane Discussants: David A. Cox, Jose P.S. Henriques, Massimo Napodano, Bernhard Witzenbichler 8:20 pm - A Mesh-Covered Stent Chaim S. Lotan Moderator: Ajay J. Kirtane Discussants: David A. Cox, Jose P.S. Henriques, Massimo Napodano, Bernhard Witzenbichler 8:28 pm - Do Whatever You Want: In Most Cases, it Doesn t Matter Holger Thiele Moderator: Ajay J. Kirtane Discussants: David A. Cox, Jose P.S. Henriques, Massimo Napodano, Bernhard Witzenbichler 8:36 pm - Discussion with Q&A 8:48 pm - Adjourn Satellite Symposia - October 23-26,

180 F O U N D AT I O N Satellite Symposia C A R D I O VA S C U L A R R E S E A R C H Emerging Technologies for Peripheral Interventions: Device Selection, Technical Approach, and Clinical Outcomes Loews Miami Beach Hotel, Americana Ballroom-Salon 4 Sponsored by Cardiovascular Research Foundation and Baptist Health South Florida Supported through an educational grant from Cardiovascular Systems, Inc. This activity has been approved for 1.5 AMA PRA Category 1 Credits Chairs Juan F. Granada, MD The CRF Skirball Research Center Orangeburg, NY Barry T. Katzen, MD Baptist Cardiac and Vascular Institute Miami, FL faculty David J. Cohen, MD Saint Luke s Mid-America Heart Institute Kansas City, MO Tony Das, MD Presbyterian Heart Institute-Dallas Dallas, TX D. Christopher Metzger, MD Wellmont CVA Heart Institute Kingsport, TN Jihad A. Mustapha, MD Metro Heart and Vascular Institute Wyoming, MI Alex Powell, MD Baptist Cardiac and Vascular Institute Miami, FL Dierk Scheinert, MD Park-Krankenhaus Leipzig Leipzig, Germany Renu Virmani, MD CVPath Institute, Inc Gaithersburg, MD Agenda 6:30 pm - Dinner Reception 7:00 pm - Opening Remarks Barry T. Katzen 7:05 pm - Pathological Features of Peripheral Atherosclerotic Disease: Implications for Device Selection Renu Virmani 7:15 pm - Impact of SFA Lesion Complexity on Device Selection and Clinical Outcomes (Case-Based Presentation) D. Christopher Metzger 7:25 pm - Technical Approaches to BTK Intervention: Device Selection and Anatomical Considerations (Case-Based Presentation) Jihad A. Mustapha 7:35 pm - Discussion 7:45 pm - Reentry Devices: A Necessary Interventional Tool! (Case-based Presentation) Alex Powell 7:55 pm - Calcium Ablation in the Periphery: A Critical Review of Available Technologies and Clinical Data (Case-based Presentation) Tony Das 8:05 pm - DCB, Atherectomy, and Stents: Technical and Biological Considerations for Device Selection Juan F. Granada 8:15 pm - Cost-Benefit Analysis and Multiple Device Use for Peripheral Interventions David J. Cohen 8:25 pm - Wrap-up Discussion 8:30 pm - Adjourn The Novel FIREHAWK DES Platform: Targeting the Future The Perry South Beach Hotel, Ballroom Sponsored by MicroPort Medical Chairs Alexandre Abizaid, MD, PhD Instituto Dante Pazzanese de Cardiologia São Paulo, Brazil Jiyan Chen, MD Guangdong Provincial People s Hospital Guangzhou, China Martin B. Leon, MD NewYork-Presbyterian Hospital/ Columbia University Medical Center Bo Xu, MD Fu Wai Hospital, National Center for Cardiovascular Diseases Beijing, China faculty Shaoliang Chen, MD Affiliated Nanjing First Hospital of Nanjing Medical University Nanjing, China Run-Lin Gao, MD Fu Wai Hospital, National Center for Cardiovascular Diseases Beijing, China Yaling Han, MD Shenyang Northern Hospital Shenyang, China Alexandra J. Lansky, MD Yale School of Medicine New Haven, CT Weifeng Shen, MD Affiliated Ruijin Hospital of Shanghai Jiao Tong University School of Medicine Shanghai, China Haichang Wang, MD Xijing Hospital, the Fourth Military Medical University Xi an, China Yuejin Yang, MD Fu Wai Hospital, National Center for Cardiovascular Diseases Beijing, China Agenda 6:30 pm - Dinner Reception 7:00 pm - Opening: Ideal DES Platform for the Future Martin B. Leon 7:10 pm - FIREHAWK Abluminal Groove Filled Biodegradable Polymer Sirolimus-Eluting Stent: Angiographic and Clinical Results Run-Lin Gao 7:30 pm - Discussion with Q&A 7:40 pm - IVUS Findings of FIREHAWK from TARGET I Trial Weifeng Shen 7:50 pm - Angioscopic Findings of FIREHAWK vs. XIENCE V from TARGET I Trial Shaoliang Chen 8:00 pm - Case Presentation with FIREHAWK: IVUS and FFR Guided PCI for Complex Left Main with Multivessel Disease Yuejin Yang 8:10 pm - Discussion with Q&A 8:30 pm - Adjourn RESPECT PFO Closure Trial: The Investigator Perspective Loews Miami Beach Hotel, Poinciana Ballroom Sponsored by St. Jude Medical Chairs Jeffrey L. Saver, MD University of California Los Angeles, CA John D. Carroll, MD University of Colorado Denver Denver, CO faculty Lee A. MacDonald, MD South Denver Cardiology Littleton, CO 178

181 F O U N D AT I O N The World s Premier Interventional Experience TCT2012 Transcatheter Cardiovascular Therapeutics Richard Smalling, MD, PhD Memorial Hermann Heart and Vascular Institute Houston, TX David E. Thaler, MD, PhD Tufts Medical Center Boston, MA Agenda 6:30 pm - Dinner Reception CAUTION: AMPLATZER PFO Occluder is an investigational device. Limited by Federal (or U.S.) law to investigational use. Not available for sale in the U.S. 7:00 pm - Introduction 7:05 pm - RESPECT Trial: Design Review and Primary Outcomes John D. Carroll 7:20 pm - How RESPECT Differs from Closure I Richard Smalling 7:30 pm - RESPECT and Recent Pharmacological Trials David E. Thaler 7:40 pm - RESPECT from the Neuro Perspective Jeffrey L. Saver 7:50 pm - RESPECT: A Single-Center Experience in IC and Neuro Partnership Lee A. MacDonald 8:00 pm - RESPECT Results: Impact on International Practice 8:10 pm - Panel Discussion: Collaborating for Optimal Patient Care Moderator: John D. Carroll 8:35 pm - Q&A 8:45 pm - Adjourn Friday, October 26 Breakfast Meetings C A R D I O VA S C U L A R R E S E A R C H Guidewire Design and Selection: A User s Guide Miami Beach Convention Center, C Sponsored by Cardiovascular Research Foundation Supported through an educational grant from Abbott Vascular This activity has been approved for 1 AMA PRA Category 1 Credit Chairs Ajay J. Kirtane, MD, SM NewYork-Presbyterian Hospital/ Columbia University Medical Center Martin B. Leon, MD NewYork-Presbyterian Hospital/ Columbia University Medical Center faculty Christopher E. Buller, MD St. Michael s Hospital Toronto, Canada David E. Kandzari, MD Piedmont Heart Institute Atlanta, GA Agenda 6:30 am - Breakfast 7:00 am - Welcome and Introductions Ajay J. Kirtane 7:05 am - Anatomy and Design of Coronary Guidewires 101: Engineering for the Interventionalist Christopher E. Buller 7:15 am - Applied Use of Coronary Guidewires: Basic Principles Martin B. Leon Management of Complex PCI Patients: Award-Winning Case Presentations Miami Beach Convention Center, C Sponsored by Cardiovascular Research Foundation Supported through an educational grant from ABIOMED, Inc. Chairs Mauricio Cohen, MD Miller School of Medicine, University of Miami Miami, FL Sean Pinney, MD Mount Sinai Medical Center faculty Maya Kommineni, MD University of Chicago Chicago, IL Aung Myat, MD King s College London London, United Kingdom Sibin Zacharius, MD Beaumont Hospital Royal Oak, MI Agenda 6:30 am - Breakfast 7:00 am - Impella-Supported LMCA/ Multivessel Coronary Intervention: Case Selection, Technical Considerations, and Interventional Strategy Maya Kommineni 7:15 am - Discussion with Q&A 7:20 am - Impella-Assisted Unprotected Left Main Stenting Requiring Preemptive Iliac Revascularization Sibin Zacharius 7:35 am - Discussion with Q&A 7:40 am - The Impella 2.5 Percutaneous LVAD: Essential Hemodynamic Support During Emergency High-Risk Multivessel Percutaneous Coronary Intervention Aung Myat 7:55 am - Discussion with Q&A 8:00 am - Adjourn Satellite Symposia - October 23-26, 2012 Case Presentations 7:30 am - CTO Wires: Antegrade and Retrograde Approaches David E. Kandzari 7:40 am - Hydrophilic and Support Wires Ajay J. Kirtane 7:50 am - Discussion with Q&A 8:00 am - Adjourn 179

182 Satellite Symposia Intraaortic Balloon Counterpulsation for Percutaneous Aortic Valve or Complex PCI Procedures: Award Winning Case Presentations Miami Beach Convention Center, C Sponsored by Cardiovascular Research Foundation Supported through an educational grant from MAQUET Cardiovascular Chairs Tayo A. Addo, MD UT Southwestern Medical Center Dallas, TX Vijayalakshmi Kunadian, MBBS, MD Freeman Hospital Newcastle upon Tyne, United Kingdom faculty Teeranan Angkananard, MD Srinakharinwiroth University Nakorn-nayok, Thailand Chiara Bernelli, MD San Raffaele Hospital, Milan Milan, Italy Ankur Kalra, MD Minneapolis Heart Institute at Abbott Northwestern Hospital Minneapolis, MN Agenda 6:30 am - Breakfast 7:00 am - Peripartum Acute ST-Elevation Myocardial Infarction from Spontaneous Coronary Artery Dissection Ankur Kalra 7:15 am - Discussion with Q&A 7:20 am - Salvage Percutaneous Mitral Valve Repair with MitraClip in a Patient with Cardiogenic Shock: The Essential Role of the IABP Chiara Bernelli 7:35 am - Discussion with Q&A 7:40 am - Thai Athlete with Sudden VF Cardiac Arrest Teeranan Angkananard 7:55 am - Discussion with Q&A 8:00 am - Adjourn 180

183 The World s Premier Interventional Experience TCT2012 Save the Date Transcatheter Cardiovascular Therapeutics Celebrating Partnerships in Improving Patient Care Satellite Symposia - October 23-26, 2012 HONORING THE AMERICAN COLLEGE OF CARDIOLOGY AND SPECIAL GUESTS Friday, December 14, :30 PM Mandarin Oriental Time Warner Center 80 Columbus Circle Cocktails, Dinner, and Dancing For more information, please visit or contact Irma Damhuis at or [email protected]

184 35 w x 48 t 35 w x 48 t 35 w x 48 t 35 w x 48 t Poster Abstract Map Cath Lab Advances 23 faces Diabetic Patients (19 faces) Unusual Coronary Pathology: Spasm, Spotaneous Dissection, and Others (10 faces) Gender, Age, and Other Demographic Considerations (15 faces) Vascular Access (37 faces) Statins, Beta-blockers, and Other Pharmacologic Agents (9 faces) Chronic Total Occlusions (18 faces) LM Stenting (18 faces) Bifurcation Stenting (18 faces) Structural Non-Valvular, HOCM & Congenital Heart Disease (10 faces) Mitral Valve Disease and Intervention (21 faces) Antithrombin and Antiplatelet Agents (34 faces) Pulmonary Thromboembolism and Hypertension and Tricuspid Disease (6 faces) PFO,ASD,and Congenital Heart Disease(9 faces) Aortic Valve Disease and TAVR (111 faces) Chronic Kidney Disease and Acute Renal Insufficiency ( ) 18 faces EVAR and TEVAR ( ) 18 faces Peripheral Vascular Disease and Intervention ( ) faces Carotid and Neurovascular Disease and Intervention ( ) 14 faces Renal Denervation ( ) 14 faces IMAGING (73 faces) Physiologic Assessment ( ) 23 faces Stent Fracture and Longitudinal Deformation (12 faces) Heart Failure, LV Dysfunction, and Shock (21 faces) BVS and Bioabsorbable Polymers (22 Faces) STEMI/NSTEMI 77 faces ( ) Heart Failure, LV Dysfunction, and Shock (21 faces) Bleeding, Thrombosis, Embolization, and Other Complications (17 faces) BVS and Bioabsorbable Polymers (22 faces) BMS and DES Studies (74 faces) Drug-Coated Balloon (16 faces) ENTRANCE Entrance 182

185 The World s Premier Interventional Experience TCT2012 Transcatheter cardiovascular Therapeutics Catagories # Abstracts Coronary Antithrombin and Antiplatelet Agents Statins, Beta-blockers, and Other Pharmacologic Agents lm Stenting bifurcation Stenting bms and DES Studies Drug-Coated Balloon bvs and Bioabsorbable Polymers bleeding, Thrombosis, Embolization, and Other Complications Stent Fracture and Longitudinal Deformation STEMI/NSTEMI Chronic Total Occlusions Unusual Coronary Pathology: Spasm, Spotaneous Dissection, and Others Vascular Access Heart Failure, LV Dysfunction, and Shock Gender, Age, and Other Demographic Considerations Diabetic Patients Cath Lab Advances Other Pulmonary Thromboembolism and Hypertension and Tricuspid Disease Endovascular Carotid and Neurovascular Disease and Intervention Peripheral Vascular Disease and Intervention renal Denervation Chronic Kidney Disease and Acute Renal Insufficiency EVAR and TEVAR Imaging Imaging Physiologic Assessment Structural Aortic Valve Disease and TAVR mitral Valve Disease and Intervention PFO, ASD, and Congenital Heart Disease Structural Non-Valvular, HOCM, and Congenital Heart Disease Satellite Symposia - october 23-26,

186 Miami Beach convention Center Washington Avenue Coronary Theater International Multiplex Theater 1-2 Hands on Heart Structural Heart / Endovascular Theater Main Arena CRF Partnership Pavilion Booth Challenging Case Videos 184 Convention Center Drive

187 The World s Premier Interventional Experience TCT2012 Transcatheter cardiovascular Therapeutics Washington Avenue CRF Skirball Booth CRF / CTC Booth Presentation Theater 3 Satellite Symposia - october 23-26, 2012 TCT Global Educational Partnerships Booth Physician Training Center 3-D Theater Presentation Theater 1 Presentation Theater 2 Convention Center Drive 185

188 The people that constantly bitch about old age. Well, if you bitch about old age, what choice have you got? If you re not old, you re dead. 93-year-old Eugenie Kaye is quite a character. As a young woman, she was a member of the Czech national swim team and qualified for the 1936 Berlin Olympics with the fastest time only to be barred from competing by the Nazis because her swim club was a Jewish organization. She escaped Czechoslovakia just before Hitler occupied her country. Sadly, her family was not so fortunate. They all perished in Auschwitz. Years later, Eugenie developed serious health problems due to her failing heart valve. She knew she wouldn t survive open heart surgery. Fortunately, she was accepted into the PARTNER trial pioneered at NewYork-Presbyterian / Columbia University Medical Center, where over 500 TAVR procedures have been performed since the trial s inception the most in America. Eugenie is living a full and active life once again. She says, I thank God for NewYork-Presbyterian Hospital and the surgeon s golden hands. Here I am in full bloom! We are proud to be part of the TCT conference and look forward to our continued collaboration to advance the field of cardiovascular medicine and improve care for patients everywhere. Visit NewYork-Presbyterian s booth outside the main arena.

189

190 Embolic Protection Coronary Stent MicroNet Mesh-Based Stent Designed to: s s Trap Thrombus Seal Ruptured Plague s s Prevent Distal Embolization Optimize Reflow Join the InspireMD Evening Symposium: October 24th, 6:30PM, Ritz Carlton Hotel, Salon 1&2 MGuard Embolic Protection Stent: A New Era in STEMI Treatment Chairman: Gregg W. Stone > Visit us at Booth #867 Not available for sale in the USA MAL berlinerdesign THE ONLY EMBOLIC PROTECTION STENT for AMI PATIENTS

191

192 Evolutionary Change. Revolutionary Device. Visit Gore at Booth 362 Available in 6 Fr Introducing the newest evolution of the GORE VIABAHN Endoprosthesis with Heparin Bioactive Surface Now with an even lower delivery profile, GORE VIABAHN Device offers more options for endoluminal bypass. 6 Fr delivery profile for 5 and 6 mm, 7 Fr delivery profile for 7 and 8 mm devices 0.018" / 0.014" guidewire compatibility Intended to provide thromboresistant surface 120 cm catheter length INTENDED USE / INDICATIONS The GORE VIABAHN Endoprosthesis is indicated for improving blood flow in patients with symptomatic peripheral arterial disease in superficial femoral artery lesions with reference vessel diameters ranging from mm. The GORE VIABAHN Endoprosthesis is indicated for improving blood flow in patients with symptomatic peripheral arterial disease in iliac artery lesions with reference vessel diameters ranging from mm. CONTRAINDICATIONS The GORE VIABAHN Endoprosthesis is contraindicated for non-compliant lesions where full expansion of an angioplasty balloon catheter was not achieved during predilatation, or where lesions cannot be dilated sufficiently to allow passage of the delivery system. Do not use the GORE VIABAHN Endoprosthesis with Heparin Bioactive Surface in patients with known hypersensitivity to heparin, including those patients who have had a previous incidence of Heparin-Induced Thrombocytopenia (HIT) type II. Refer to Instructions for Use at goremedical.com for a complete description of all warnings, precautions and adverse events. PERFORMANCE by design Products listed may not be available in all markets. GORE, PERFORMANCE BY DESIGN, VIABAHN, and designs are trademarks of W. L. Gore & Associates W. L. Gore & Associates, Inc. AR0374-EN1 JULY 2012

193

194 The XIENCE V, XIENCE nano, XIENCE PRIME and XIENCE PRIME LL (XIENCE Family) of Everolimus Eluting Coronary Stents on the MULTI- LINK VISION or MULTI-LINK MINI VISION Delivery Systems INDICATIONS The XIENCE Family of Everolimus Eluting Coronary Stent Systems are indicated for improving coronary luminal diameter in patients with symptomatic heart disease due to de novo native coronary artery lesions (XIENCE V and XIENCE nano length 28 mm and XIENCE PRIME and XIENCE PRIME LL length 32 mm) with reference vessel diameters of 2.25 mm to 4.25 mm. CONTRAINDICATIONS The XIENCE Family of stents is contraindicated for use in patients: coagulant therapy balloon inflation or proper placement of the stent or stent delivery system everolimus or structurally-related compounds, cobalt, chromium, nickel, tungsten, acrylic and/ or fluoropolymers. WARNINGS not been opened or damaged prior to use. because device use has been associated with stent thrombosis, vascular complications and/ or bleeding events. who are not likely to comply with the recommended antiplatelet therapy. PRECAUTIONS by physicians who have received appropriate training. hospitals where emergency coronary artery bypass graft surgery is accessible. dilatation of the arterial segment containing the stent. Long-term outcomes following repeat dilatation of the stent are presently unknown. patients with severe contrast agent allergies. catheter tip during stent delivery, deployment and balloon withdrawal. Before withdrawing the balloon deflation by fluoroscopy to avoid guiding catheter movement into the vessel and infarction (MI) or death. Indications for Use, patient outcomes may differ from the results observed in the SPIRIT family of trials. and lesions outside of the labeled indications may have an increased risk of adverse events, including stent thrombosis, stent embolization, MI or death. cyclosporine is associated with increased serum cholesterol and triglycerides levels. proportional to the number and total length of implanted stents. See Instructions for Use for current data on multiple stent implantation. of stents have not been established for subject populations with the following clinical settings: Patients with prior target lesion or in-stent restenosis related brachytherapy, patients in whom mechanical atherectomy devices or laser angioplasty devices are used simultaneously, women who are pregnant or lactating, men intending to father children, pediatric patients, unresolved vessel thrombus at the lesion site, coronary artery reference vessel diameters < 2.25 mm or > 4.25 mm or lesion length > 32 mm, lesions located in saphenous vein grafts, unprotected left main coronary artery, ostial lesions, chronic total occlusions, lesions located at a bifurcation or previously stented lesions, diffuse disease or poor flow (TIMI < 1) distal myocardial infarction (AMI) or evidence of thrombus in target vessel, moderate or severe stent restenosis. clearance of some prescription medications when it was administered orally along with cyclosporine (CsA). Formal drug interaction studies have not been performed with the XIENCE Family of stents because of limited the stent. Consideration should be given to patients taking other immunosuppressive agents or who are at risk for immune suppression. patients and advanced renal cell carcinoma patients was associated with increased serum cholesterol and triglycerides, which in some the XIENCE Family of stents, in single and in length for XIENCE V and XIENCE nano and up to 71 mm in length for XIENCE PRIME and XIENCE PRIME LL, are MR Conditional. They can be scanned safely under the conditions in the Instructions for Use. handled, placed, implanted and removed according to the Instructions for Use. POTENTIAL ADVERSE EVENTS Adverse events (in alphabetical order) which may be associated with coronary stent use in native coronary arteries include but are not limited to: or hemorrhage, Acute myocardial infarction, Allergic reaction or hypersensitivity to contrast agent or cobalt, chromium, nickel, tungsten, acrylic and fluoropolymers; and drug reactions to antiplatelet drugs or contrast agent, Aneurysm, Arterial perforation and injury to the coronary artery, Arterial rupture, ventricular, Bleeding complications, which Coronary artery spasm, Coronary or stent embolism, Coronary or stent thrombosis, emboli (air, tissue or thrombotic), Emergent or non-emergent coronary artery bypass graft surgery, Fever, Hypotension and/or hypertension, Infection and pain at insertion site, Injury to the coronary artery, Ischemia (myocardial), Myocardial infarction (MI), Nausea and vomiting, Palpitations, Peripheral ischemia (due to vascular injury), Pseudoaneurysm, Renal Failure, Restenosis of the stented segment of the artery, Shock/pulmonary edema, Stroke/ cerebrovascular accident (CVA), Total occlusion of coronary artery, Unstable or stable angina pectoris, Vascular complications including at Vessel dissection. Adverse events associated with daily oral administration of everolimus to organ transplant patients include but are not limited to: Hematuria; Hyperglycemia (may include new onset of diabetes); Hyperlipidemia; Hyperkalemia; Hypertension; Hypokalemia; Hypomagnesemia; Hypophosphatemia; Increased serum creatinine; Infections and serious infections: bacterial, viral, fungal, and protozoal infections (may include herpes virus infection, polyoma virus infection which may be associated with BK virus associated nephropathy, and/or other opportunistic infections); Insomnia; Interaction with strong inhibitors and inducers of CY3PA4; Leukopenia; Lymphoma and other malignancies (including skin cancer); Male infertility (azospermia and/or oligospermia); Mucosal inflammation (including oral ulceration and oral mucositis); Nausea; Neutropenia; Non-infectious procedural, and back; Proteinuria; Pruritus; Thrombotic microangiopathy (TMA)/Thrombotic thrombocytopenic purpura (TTP)/Hemolytic uremic syndrome (HUS); Tremor; Urinary tract infection; Upper respiratory tract infection; Vomiting. contact with those that have had live vaccines should be avoided. Fetal harm can occur when administered to a pregnant woman. There may be other potential adverse events that are unforeseen at this time. Prior to use, please reference the Instructions for Use at for more information on indications, contraindications, warnings, precautions and adverse events. XIENCE V, XIENCE nano, XIENCE PRIME, XIENCE PRIME LL, MULTI-LINK VISION and MULTI-LINK MINI VISION are trademarks of the Abbott Group of Companies Abbott. All rights reserved. AP US Rev. B 08/12

195 La Innovación Importa Technologies that transform. Products that perform. TAVR LAA Closure Coronary Stents Renal Denervation Imaging & Specialty 2012 Boston Scientific Corporation or its affiliates. All rights reserved. IC AA AUG2012

196 TCT2012 program 192