From the Cover. Contents. May 21, 2013 u vol. 110 u no. 21 u CORE CONCEPTS THIS WEEK IN PNAS QNAS LETTERS (ONLINE ONLY) COMMENTARIES

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1 May 21, 2013 u vol. 110 u no. 21 u Cover image: Pictured are rice farmers in the village of Wongaya Gede in Bali, Indonesia, where the landscape is a rich mosaic of rice terraces and agroforestry crops and has been listed as a UNESCO World Heritage cultural site. These farmers adapt constantly, combining traditional irrigation and agronomic techniques with innovative use of genetic material and locally adapted mechanization. Jeffrey Sayer and Kenneth G. Cassman suggest that agricultural innovations such as those used in Bali are essential to address concerns about the environmental impact of agriculture while producing enough food to support the world s population. See the Introduction to the Agricultural Innovation to Protect the Environment Special Feature by Sayer and Cassman on pages Image courtesy of Agni Klintuni Boedhihartono. From the Cover 8345 Agricultural innovation to protect the environment 8447 Winding patterns of rivers 8597 Glucose uptake in the ocean 8668 Using Listeria against cancer Contents THIS WEEK IN PNAS CORE CONCEPTS 8319 Metamaterials Stephen Ornes 8315 In This Issue LETTERS (ONLINE ONLY) E1877 E1878 The oceanic cadmium cycle: Biological mistake or utilization? François M. M. Morel Reply to Morel: Cadmium as a micronutrient and macrotoxin in the oceans Tristan J. Horner, Renee B. Y. Lee, Gideon M. Henderson, and Rosalind E. M. Rickaby SCIENCE AND CULTURE 8317 Radiated relics Rebecca Horne INNER WORKINGS 8318 Three-dimensional viewing in the deep sea Mark Schrope Free online through the PNAS open access option. QNAS 8320 QnAs with Randolph Blake Beth Azar See Inaugural Article on page 8337 COMMENTARIES 8321 Sinuous rivers Victor R. Baker See companion article on page More mixotrophy in the marine microbial mix Lisa R. Moore See companion article on page Single-agent combinatorial cancer therapy Jochen Stritzker and Aladar A. Szalay See companion article on page Integrating the HIV-1 assembly/maturation pathway Marc Potempa and Ronald Swanstrom See companion article on page 8690 PNAS u May 21, 2013 u vol. 110 u no. 21 u iii ix

2 PNAS PLUS 8329 SIGNIFICANCE STATEMENTS BIOLOGICAL SCIENCES E1889 Dynamic gradients of an intermediate filament-like cytoskeleton are recruited by a polarity landmark during apical growth Katsuya Fuchino, Sonchita Bagchi, Stuart Cantlay, Linda Sandblad, Di Wu, Jessica Bergman, Masood Kamali-Moghaddam, Klas Flärdh, and Nora Ausmees E1898 DEVELOPMENTAL BIOLOGY Kif7 is required for the patterning and differentiation of the diaphragm in a model of syndromic congenital diaphragmatic hernia Garry L. Coles and Kate G. Ackerman AUTHOR SUMMARIES BIOLOGICAL SCIENCES 8331 Structural analysis of Stc1 provides insights into the coupling of RNAi and chromatin modification Chao He, Sreerekha S. Pillai, Francesca Taglini, Fudong Li, Ke Ruan, Jiahai Zhang, Jihui Wu, Yunyu Shi, and Elizabeth H. Bayne See full research article on page E1879 of MICROBIOLOGY 8333 An essential role for γ-herpesvirus latency-associated nuclear antigen homolog in an acute lymphoproliferative disease of cattle Leonor Palmeira, Océane Sorel, Willem Van Campe, Christel Boudry, Stefan Roels, Françoise Myster, Anca Reschner, Pierre G. Coulie, Pierre Kerkhofs, Alain Vanderplasschen, and Benjamin G. Dewals See full research article on page E1933 of E1906 E1913 E1923 E1953 E1963 GENETICS Robust measurement of telomere length in single cells Fang Wang, Xinghua Pan, Keri Kalmbach, Michelle L. Seth-Smith, Xiaoying Ye, Danielle M. F. Antumes, Yu Yin, Lin Liu, David L. Keefe, and Sherman M. Weissman IMMUNOLOGY Motile invaded neutrophils in the small intestine of Toxoplasma gondii-infected mice reveal a potential mechanism for parasite spread Janine L. Coombes, Brittany A. Charsar, Seong-Ji Han, Joanna Halkias, Shiao Wei Chan, Anita A. Koshy, Boris Striepen, and Ellen A. Robey MEDICAL SCIENCES Farnesylation of lamin B1 is important for retention of nuclear chromatin during neuronal migration Hea-Jin Jung, Chika Nobumori, Chris N. Goulbourne, Yiping Tu, John M. Lee, Angelica Tatar, Daniel Wu, Yuko Yoshinaga, Pieter J. de Jong, Catherine Coffinier, Loren G. Fong, and Stephen G. Young NEUROSCIENCE Human amnesia and the medial temporal lobe illuminated by neuropsychological and neurohistological findings for patient E.P. Ricardo Insausti, Jacopo Annese, David G. Amaral, and Larry R. Squire PLANT BIOLOGY WRKY8 transcription factor functions in the TMV-cg defense response by mediating both abscisic acid and ethylene signaling in Arabidopsis Ligang Chen, Liping Zhang, Daibo Li, Fang Wang, and Diqiu Yu NEUROSCIENCE 8335 Nogo-A is a negative regulator of CNS angiogenesis Thomas Wälchli, Vincent Pernet, Oliver Weinmann, Jau-Ye Shiu, Anna Guzik-Kornacka, Guillaume Decrey, Deniz Yüksel, Hannah Schneider, Johannes Vogel, Donald E. Ingber, Viola Vogel, Karl Frei, and Martin E. Schwab See full research article on page E1943 of INAUGURAL ARTICLE 8337 A monocular contribution to stimulus rivalry Jan Brascamp, Hansem Sohn, Sang-Hun Lee, and Randolph Blake See QnAs on page 8320 AGRICULTURAL INNOVATION TO PROTECT THE ENVIRONMENT SPECIAL FEATURE INTRODUCTION 8345 Agricultural innovation to protect the environment Jeffrey Sayer and Kenneth G. Cassman PERSPECTIVE 8349 Ten principles for a landscape approach to reconciling agriculture, conservation, and other competing land uses Jeffrey Sayer, Terry Sunderland, Jaboury Ghazoul, Jean-Laurent Pfund, Douglas Sheil, Erik Meijaard, Michelle Venter, Agni Klintuni Boedhihartono, Michael Day, Claude Garcia, Cora van Oosten, and Louise E. Buck RESEARCH ARTICLES 8357 Addressing uncertainty in adaptation planning for agriculture Sonja J. Vermeulen, Andrew J. Challinor, Philip K. Thornton, Bruce M. Campbell, Nishadi Eriyagama, Joost M. Vervoort, James Kinyangi, Andy Jarvis, Peter Läderach, Julian Ramirez-Villegas, Kathryn J. Nicklin, Ed Hawkins, and Daniel R. Smith iv u

3 8363 Green Revolution research saved an estimated 18 to 27 million hectares from being brought into agricultural production James R. Stevenson, Nelson Villoria, Derek Byerlee, Timothy Kelley, and Mywish Maredia 8369 Innovative grassland management systems for environmental and livelihood benefits David R. Kemp, Han Guodong, Hou Xiangyang, David L. Michalk, Hou Fujiang, Wu Jianping, and Zhang Yingjun 8375 New technologies reduce greenhouse gas emissions from nitrogenous fertilizer in China Wei-feng Zhang, Zheng-xia Dou, Pan He, Xiao-Tang Ju, David Powlson, Dave Chadwick, David Norse, Yue-Lai Lu, Ying Zhang, Liang Wu, Xin-Ping Chen, Kenneth G. Cassman, and Fu-Suo Zhang 8381 Scope for improved eco-efficiency varies among diverse cropping systems Peter S. Carberry, Wei-li Liang, Stephen Twomlow, Dean P. Holzworth, John P. Dimes, Tim McClelland, Neil I. Huth, Fu Chen, Zvi Hochman, and Brian A. Keating 8387 Interactive effects among ecosystem services and management practices on crop production: Pollination in coffee agroforestry systems Virginie Boreux, Cheppudira G. Kushalappa, Philippe Vaast, and Jaboury Ghazoul 8393 Innovations in capture fisheries are an imperative for nutrition security in the developing world Stephen J. Hall, Ray Hilborn, Neil L. Andrew, and Edward H. Allison 8399 Zoonosis emergence linked to agricultural intensification and environmental change Bryony A. Jones, Delia Grace, Richard Kock, Silvia Alonso, Jonathan Rushton, Mohammed Y. Said, Declan McKeever, Florence Mutua, Jarrah Young, John McDermott, and Dirk Udo Pfeiffer PHYSICAL SCIENCES APPLIED MATHEMATICS 8405 The phase transition of matrix recovery from Gaussian measurements matches the minimax MSE of matrix denoising David L. Donoho, Matan Gavish, and Andrea Montanari 8411 A Huygens principle for diffusion and anomalous diffusion in spatially extended systems Georg A. Gottwald and Ian Melbourne CHEMISTRY 8427 Study of the fluoro- and chlorodimethylbutyl cations George A. Olah, G. K. Surya Prakash, and Golam Rasul 8431 Direct observation of intermediates formed during steady-state electrocatalytic O 2 reduction by iron porphyrins Kushal Sengupta, Sudipta Chatterjee, Subhra Samanta, and Abhishek Dey 8437 Methanol incorporation in clathrate hydrates and the implications for oil and gas pipeline flow assurance and icy planetary bodies Kyuchul Shin, Konstantin A. Udachin, Igor L. Moudrakovski, Donald M. Leek, Saman Alavi, Christopher I. Ratcliffe, and John A. Ripmeester 8537 Optimal fold symmetry of LH2 rings on a photosynthetic membrane Liam Cleary, Hang Chen, Chern Chuang, Robert J. Silbey, and Jianshu Cao 8543 Salts drive controllable multilayered upright assembly of amyloid-like peptides at mica/water interface Bin Dai, Seung-gu Kang, Tien Huynh, Haozhi Lei, Matteo Castelli, Jun Hu, Yi Zhang, and Ruhong Zhou EARTH, ATMOSPHERIC, AND PLANETARY SCIENCES 8443 Sulfur isotopes in coal constrain the evolution of the Phanerozoic sulfur cycle Donald E. Canfield 8447 Generic theory for channel sinuosity Eli D. Lazarus and José Antonio Constantine See Commentary on page Persistence and origin of the lunar core dynamo Clément Suavet, Benjamin P. Weiss, William S. Cassata, David L. Shuster, Jérôme Gattacceca, Lindsey Chan, Ian Garrick-Bethell, James W. Head, Timothy L. Grove, and Michael D. Fuller ENGINEERING 8459 Biopolymer-reinforced synthetic granular nanocomposites for affordable point-of-use water purification Mohan Udhaya Sankar, Sahaja Aigal, Shihabudheen M. Maliyekkal, Amrita Chaudhary, Anshup, Avula Anil Kumar, Kamalesh Chaudhari, and Thalappil Pradeep 8621 Lymphatic abnormalities are associated with RASA1 gene mutations in mouse and man Patricia E. Burrows, Manuel L. Gonzalez-Garay, John C. Rasmussen, Melissa B. Aldrich, Renie Guilliod, Erik A. Maus, Caroline E. Fife, Sunkuk Kwon, Philip E. Lapinski, Philip D. King, and Eva M. Sevick-Muraca APPLIED PHYSICAL SCIENCES 8417 Fluorescence thermometry enhanced by the quantum coherence of single spins in diamond David M. Toyli, Charles F. de las Casas, David J. Christle, Viatcheslav V. Dobrovitski, and David D. Awschalom 8422 Control of slippage with tunable bubble mattresses Elif Karatay, A. Sander Haase, Claas Willem Visser, Chao Sun, Detlef Lohse, Peichun Amy Tsai, and Rob G. H. Lammertink SOCIAL SCIENCES ECONOMIC SCIENCES 8363 Green Revolution research saved an estimated 18 to 27 million hectares from being brought into agricultural production James R. Stevenson, Nelson Villoria, Derek Byerlee, Timothy Kelley, and Mywish Maredia PNAS u May 21, 2013 u vol. 110 u no. 21 u v

4 ENVIRONMENTAL SCIENCES 8357 Addressing uncertainty in adaptation planning for agriculture Sonja J. Vermeulen, Andrew J. Challinor, Philip K. Thornton, Bruce M. Campbell, Nishadi Eriyagama, Joost M. Vervoort, James Kinyangi, Andy Jarvis, Peter Läderach, Julian Ramirez-Villegas, Kathryn J. Nicklin, Ed Hawkins, and Daniel R. Smith PSYCHOLOGICAL AND COGNITIVE SCIENCES 8337 A monocular contribution to stimulus rivalry Jan Brascamp, Hansem Sohn, Sang-Hun Lee, and Randolph Blake See QnAs on page 8320 SUSTAINABILITY SCIENCE 8369 Innovative grassland management systems for environmental and livelihood benefits David R. Kemp, Han Guodong, Hou Xiangyang, David L. Michalk, Hou Fujiang, Wu Jianping, and Zhang Yingjun 8375 New technologies reduce greenhouse gas emissions from nitrogenous fertilizer in China Wei-feng Zhang, Zheng-xia Dou, Pan He, Xiao-Tang Ju, David Powlson, Dave Chadwick, David Norse, Yue-Lai Lu, Ying Zhang, Liang Wu, Xin-Ping Chen, Kenneth G. Cassman, and Fu-Suo Zhang 8387 Interactive effects among ecosystem services and management practices on crop production: Pollination in coffee agroforestry systems Virginie Boreux, Cheppudira G. Kushalappa, Philippe Vaast, and Jaboury Ghazoul BIOLOGICAL SCIENCES AGRICULTURAL SCIENCES 8369 Innovative grassland management systems for environmental and livelihood benefits David R. Kemp, Han Guodong, Hou Xiangyang, David L. Michalk, Hou Fujiang, Wu Jianping, and Zhang Yingjun 8375 New technologies reduce greenhouse gas emissions from nitrogenous fertilizer in China Wei-feng Zhang, Zheng-xia Dou, Pan He, Xiao-Tang Ju, David Powlson, Dave Chadwick, David Norse, Yue-Lai Lu, Ying Zhang, Liang Wu, Xin-Ping Chen, Kenneth G. Cassman, and Fu-Suo Zhang 8381 Scope for improved eco-efficiency varies among diverse cropping systems Peter S. Carberry, Wei-li Liang, Stephen Twomlow, Dean P. Holzworth, John P. Dimes, Tim McClelland, Neil I. Huth, Fu Chen, Zvi Hochman, and Brian A. Keating 8465 Retargeting of the Bacillus thuringiensis toxin Cyt2Aa against hemipteran insect pests Nanasaheb P. Chougule, Huarong Li, Sijun Liu, Lucas B. Linz, Kenneth E. Narva, Thomas Meade, and Bryony C. Bonning ANTHROPOLOGY 8471 Ultraconserved words point to deep language ancestry across Eurasia Mark Pagel, Quentin D. Atkinson, Andreea S. Calude, and Andrew Meade BIOCHEMISTRY 8477 Structural snapshots reveal distinct mechanisms of procaspase-3 and -7 activation Nathan D. Thomsen, James T. Koerber, and James A. Wells 8483 The posttranslational modification cascade to the thiopeptide berninamycin generates linear forms and altered macrocyclic scaffolds Steven J. Malcolmson, Travis S. Young, J. Graham Ruby, Peter Skewes-Cox, and Christopher T. Walsh 8489 Chloride binding site of neurotransmitter sodium symporters Adriana K. Kantcheva, Matthias Quick, Lei Shi, Anne-Marie Lund Winther, Sebastian Stolzenberg, Harel Weinstein, Jonathan A. Javitch, and Poul Nissen 8495 Heterochromatin protein Sir3 induces contacts between the amino terminus of histone H4 and nucleosomal DNA Feng Wang, Geng Li, Mohammed Altaf, Chenning Lu, Mark A. Currie, Aaron Johnson, and Danesh Moazed 8501 Mycobacterial toxin MazF-mt6 inhibits translation through cleavage of 23S rrna at the ribosomal A site Jason M. Schifano, Regina Edifor, Jared D. Sharp, Ming Ouyang, Arvind Konkimalla, Robert N. Husson, and Nancy A. Woychik 8507 CaBP1, a neuronal Ca 2+ sensor protein, inhibits inositol trisphosphate receptors by clamping intersubunit interactions Congmin Li, Masahiro Enomoto, Ana M. Rossi, Min-Duk Seo, Taufiq Rahman, Peter B. Stathopulos, Colin W. Taylor, Mitsuhiko Ikura, and James B. Ames 8513 Heat shock protein (Hsp) 70 is an activator of the Hsp104 motor Jungsoon Lee, Ji-Hyun Kim, Amadeo B. Biter, Bernhard Sielaff, Sukyeong Lee, and Francis T. F. Tsai 8519 X-ray structure of an AdoMet radical activase reveals an anaerobic solution for formylglycine posttranslational modification Peter J. Goldman, Tyler L. Grove, Lauren A. Sites, Martin I. McLaughlin, Squire J. Booker, and Catherine L. Drennan 8525 Phosphorylation-dependent conformational changes and domain rearrangements in Staphylococcus aureus VraR activation Paul G. Leonard, Dasantila Golemi-Kotra, and Ann M. Stock 8531 Reciprocal regulation of PKA and Rac signaling Verena A. Bachmann, Anna Riml, Roland G. Huber, George S. Baillie, Klaus R. Liedl, Taras Valovka, and Eduard Stefan BIOPHYSICS AND COMPUTATIONAL BIOLOGY 8537 Optimal fold symmetry of LH2 rings on a photosynthetic membrane Liam Cleary, Hang Chen, Chern Chuang, Robert J. Silbey, and Jianshu Cao vi u

5 8543 Salts drive controllable multilayered upright assembly of amyloid-like peptides at mica/water interface Bin Dai, Seung-gu Kang, Tien Huynh, Haozhi Lei, Matteo Castelli, Jun Hu, Yi Zhang, and Ruhong Zhou 8549 Structural plasticity of the cellular prion protein and implications in health and disease Barbara Christen, Fred F. Damberger, Daniel R. Pérez, Simone Hornemann, and Kurt Wüthrich 8555 Evidence for orphan nuclear receptor TR4 in the etiology of Cushing disease Li Du, Marvin Bergsneider, Leili Mirsadraei, Steven H. Young, Johan W. Jonker, Michael Downes, William H. Yong, Ronald M. Evans, and Anthony P. Heaney 8561 Structural basis of the relaxed state of a Ca 2+ -regulated myosin filament and its evolutionary implications John L. Woodhead, Fa-Qing Zhao, and Roger Craig 8567 Visualizing cellular interactions with a generalized proximity reporter Mark A. Sellmyer, Laura Bronsart, Hiroshi Imoto, Christopher H. Contag, Thomas J. Wandless, and Jennifer A. Prescher 8573 Cross-talk between MET and EGFR in non-small cell lung cancer involves mir-27a and Sprouty2 Mario Acunzo, Giulia Romano, Dario Palmieri, Alessandro Laganá, Michela Garofalo, Veronica Balatti, Alessandra Drusco, Mario Chiariello, Patrick Nana-Sinkam, and Carlo M. Croce 8579 Phosphorylation of the CENP-A amino-terminus in mitotic centromeric chromatin is required for kinetochore function Damien Goutte-Gattat, Muhammad Shuaib, Khalid Ouararhni, Thierry Gautier, Dimitrios A. Skoufias, Ali Hamiche, and Stefan Dimitrov DEVELOPMENTAL BIOLOGY 8585 Female mice lack adult germ-line stem cells but sustain oogenesis using stable primordial follicles Lei Lei and Allan C. Spradling 8591 Gene regulatory network for neurogenesis in a sea star embryo connects broad neural specification and localized patterning Kristen A. Yankura, Claire S. Koechlein, Abigail F. Cryan, Alys Cheatle, and Veronica F. Hinman ENVIRONMENTAL SCIENCES 8387 Interactive effects among ecosystem services and management practices on crop production: Pollination in coffee agroforestry systems Virginie Boreux, Cheppudira G. Kushalappa, Philippe Vaast, and Jaboury Ghazoul 8609 Evolution of the plankton paleome in the Black Sea from the Deglacial to Anthropocene Marco J. L. Coolen, William D. Orsi, Cherel Balkema, Christopher Quince, Keith Harris, Sean P. Sylva, Mariana Filipova-Marinova, and Liviu Giosan EVOLUTION 8615 Frequent adaptation and the McDonald Kreitman test Philipp W. Messer and Dmitri A. Petrov GENETICS 8621 Lymphatic abnormalities are associated with RASA1 gene mutations in mouse and man Patricia E. Burrows, Manuel L. Gonzalez-Garay, John C. Rasmussen, Melissa B. Aldrich, Renie Guilliod, Erik A. Maus, Caroline E. Fife, Sunkuk Kwon, Philip E. Lapinski, Philip D. King, and Eva M. Sevick-Muraca 8627 Dnmt2-dependent methylomes lack defined DNA methylation patterns Günter Raddatz, Paloma M. Guzzardo, Nelly Olova, Marcelo Rosado Fantappié, Markus Rampp, Matthias Schaefer, Wolf Reik, Gregory J. Hannon, and Frank Lyko 8632 Palb2 synergizes with Trp53 to suppress mammary tumor formation in a model of inherited breast cancer Christian Bowman-Colin, Bing Xia, Samuel Bunting, Christiaan Klijn, Rinske Drost, Peter Bouwman, Laura Fineman, Xixi Chen, Aedin C. Culhane, Hong Cai, Scott J. Rodig, Roderick T. Bronson, Jos Jonkers, Andre Nussenzweig, Chryssa Kanellopoulou, and David M. Livingston 8638 Parkin overexpression during aging reduces proteotoxicity, alters mitochondrial dynamics, and extends lifespan Anil Rana, Michael Rera, and David W. Walker 8644 Mesenchymal glioma stem cells are maintained by activated glycolytic metabolism involving aldehyde dehydrogenase 1A3 Ping Mao, Kaushal Joshi, Jianfeng Li, Sung-Hak Kim, Peipei Li, Lucas Santana-Santos, Soumya Luthra, Uma R. Chandran, Panayiotis V. Benos, Luke Smith, Maode Wang, Bo Hu, Shi-Yuan Cheng, Robert W. Sobol, and Ichiro Nakano ECOLOGY 8597 Prochlorococcus can use the Pro1404 transporter to take up glucose at nanomolar concentrations in the Atlantic Ocean María del Carmen Muñoz-Marín, Ignacio Luque, Mikhail V. Zubkov, Polly G. Hill, Jesús Diez, and José Manuel García-Fernández See Commentary on page Consumers mediate the effects of experimental ocean acidification and warming on primary producers Christian Alsterberg, Johan S. Eklöf, Lars Gamfeldt, Jonathan N. Havenhand, and Kristina Sundbäck IMMUNOLOGY 8650 Expression of recombinant human complement C1q allows identification of the C1r/C1s-binding sites Isabelle Bally, Sarah Ancelet, Christine Moriscot, Florence Gonnet, Alberto Mantovani, Régis Daniel, Guy Schoehn, Gérard J. Arlaud, and Nicole M. Thielens 8656 Stat2 loss leads to cytokine-independent, cell-mediated lethality in LPS-induced sepsis William Alazawi, Helen Heath, Jennifer A. Waters, Abigail Woodfin, Alastair J. O Brien, Anthony J. Scarzello, Bin Ma, Yolanda Lopez-Otalora, Michael Jacobs, Gemma Petts, Robert D. Goldin, Sussan Nourshargh, Ana M. Gamero, and Graham R. Foster PNAS u May 21, 2013 u vol. 110 u no. 21 u vii

6 MEDICAL SCIENCES 8399 Zoonosis emergence linked to agricultural intensification and environmental change Bryony A. Jones, Delia Grace, Richard Kock, Silvia Alonso, Jonathan Rushton, Mohammed Y. Said, Declan McKeever, Florence Mutua, Jarrah Young, John McDermott, and Dirk Udo Pfeiffer 8662 Transcytosis and brain uptake of transferrin-containing nanoparticles by tuning avidity to transferrin receptor Devin T. Wiley, Paul Webster, Aaron Gale, and Mark E. Davis 8668 Nontoxic radioactive Listeria at is a highly effective therapy against metastatic pancreatic cancer Wilber Quispe-Tintaya, Dinesh Chandra, Arthee Jahangir, Matthew Harris, Arturo Casadevall, Ekaterina Dadachova, and Claudia Gravekamp See Commentary on page Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice Kimberly Martinod, Melanie Demers, Tobias A. Fuchs, Siu Ling Wong, Alexander Brill, Maureen Gallant, Jing Hu, Yanming Wang, and Denisa D. Wagner 8680 Engineering bone tissue substitutes from human induced pluripotent stem cells Giuseppe Maria de Peppo, Iván Marcos-Campos, David John Kahler, Dana Alsalman, Linshan Shang, Gordana Vunjak-Novakovic, and Darja Marolt MICROBIOLOGY 8686 Combined effect of a peptide morpholino oligonucleotide conjugate and a cell-penetrating peptide as an antibiotic Donna Wesolowski, Dulce Alonso, and Sidney Altman 8690 Allosteric integrase inhibitor potency is determined through the inhibition of HIV-1 particle maturation Kellie A. Jurado, Hao Wang, Alison Slaughter, Lei Feng, Jacques J. Kessl, Yasuhiro Koh, Weifeng Wang, Allison Ballandras-Colas, Pratiq A. Patel, James R. Fuchs, Mamuka Kvaratskhelia, and Alan Engelman See Commentary on page Mechanism for nitrogen isotope fractionation during ammonium assimilation by Escherichia coli K12 Jason Vo, William Inwood, John M. Hayes, and Sydney Kustu NEUROSCIENCE 8337 A monocular contribution to stimulus rivalry Jan Brascamp, Hansem Sohn, Sang-Hun Lee, and Randolph Blake See QnAs on page Global view of the evolution and diversity of metazoan neuropeptide signaling Gáspár Jékely 8708 Role for the kinase SGK1 in stress, depression, and glucocorticoid effects on hippocampal neurogenesis Christoph Anacker, Annamaria Cattaneo, Ksenia Musaelyan, Patricia A. Zunszain, Mark Horowitz, Raffaella Molteni, Alessia Luoni, Francesca Calabrese, Katherine Tansey, Massimo Gennarelli, Sandrine Thuret, Jack Price, Rudolf Uher, Marco A. Riva, and Carmine M. Pariante 8714 Activated microglia enhance neurogenesis via trypsinogen secretion Angeliki M. Nikolakopoulou, Ranjan Dutta, Zhihong Chen, Robert H. Miller, and Bruce D. Trapp 8720 Presynaptic maturation in auditory hair cells requires a critical period of sensory-independent spiking activity Stuart L. Johnson, Stephanie Kuhn, Christoph Franz, Neil Ingham, David N. Furness, Marlies Knipper, Karen P. Steel, John P. Adelman, Matthew C. Holley, and Walter Marcotti PHARMACOLOGY 8726 Phosphatidylinositol 4,5-bisphosphate alters pharmacological selectivity for epilepsy-causing KCNQ potassium channels Pingzheng Zhou, Haibo Yu, Min Gu, Fa-jun Nan, Zhaobing Gao, and Min Li 8732 Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels Haibo Yu, Zhihong Lin, Margrith E. Mattmann, Beiyan Zou, Cecile Terrenoire, Hongkang Zhang, Meng Wu, Owen B. McManus, Robert S. Kass, Craig W. Lindsley, Corey R. Hopkins, and Min Li PHYSIOLOGY 8738 Skeletal muscle PGC-1α controls whole-body lactate homeostasis through estrogen-related receptor α-dependent activation of LDH B and repression of LDH A Serge Summermatter, Gesa Santos, Joaquín Pérez-Schindler, and Christoph Handschin PLANT BIOLOGY 8744 Calcium-dependent protein kinase/nadph oxidase activation circuit is required for rapid defense signal propagation Ullrich Dubiella, Heike Seybold, Guido Durian, Eileen Komander, Roman Lassig, Claus-Peter Witte, Waltraud X. Schulze, and Tina Romeis SUSTAINABILITY SCIENCE 8363 Green Revolution research saved an estimated 18 to 27 million hectares from being brought into agricultural production James R. Stevenson, Nelson Villoria, Derek Byerlee, Timothy Kelley, and Mywish Maredia 8393 Innovations in capture fisheries are an imperative for nutrition security in the developing world Stephen J. Hall, Ray Hilborn, Neil L. Andrew, and Edward H. Allison CORRECTIONS 8750 Paradoxical activation and RAF inhibitor resistance of BRAF protein kinase fusions characterizing pediatric astrocytomas Angela J. Sievert, Shih-Shan Lang, Katie L. Boucher, Peter J. Madsen, Erin Slaunwhite, Namrata Choudhari, Meghan Kellet, Phillip B. Storm, and Adam C. Resnick viii u

7 IMMUNOLOGY 8750 Previously undescribed grass pollen antigens are the major inducers of T helper 2 cytokine-producing T cells in allergic individuals Véronique Schulten, Jason A. Greenbaum, Michael Hauser, Denise M. McKinney, John Sidney, Ravi Kolla, Cecilia S. Lindestam Arlehamn, Carla Oseroff, Rapheul Alam, David H. Broide, Fatima Ferreira, Howard M. Grey, Alessandro Sette, and Bjoern Peters POPULATION BIOLOGY, ECONOMIC SCIENCES 8750 Cost-effectiveness of a community-based intervention for reducing the transmission of Schistosoma haematobium and HIV in Africa Martial L. Ndeffo Mbah, Eyrun F. Kjetland, Katherine E. Atkins,EricM.Poolman,EvanW.Orenstein,LaurenAncel Meyers, Jeffrey P. Townsend, and Alison P. Galvani xi Subscription Form PNAS u May 21, 2013 u vol. 110 u no. 21 u ix