Big Data and Real World Evidence
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1 Big Data and Real World Evidence Healthcare s most powerful currency: RWE as a patient-centric approach to Big-data Dr. Benjamin Hughes 8/26/2014
2 Today s take-aways RWE a focused approach to unlock Big Value from Big Data Big Data is necessary but not sufficient - Big Data becomes valuable when organizations ask strategic and focused questions, and use information to derive insights Big Data is different from RWD and RWE RWE is a focused and patient-centric approach to Big Data Pharma underutilizes RWE- RWE s patient centric view can unlock up to $1bn of sustained value for pharma, and contribute to health system value RWE Platforms need to address systematic value capture capability builds include innovative information sourcing, technology platforms and consolidated analytical CoEs HEOR has a stake RWE can challenge HEOR & Epi norms, but can also deliver more publications at high impact factor! 2
3 Big Data means a lot of things to different people Word buzz for Real World Evidence Definitions for today Big Data: a large or complex amount of data that meets four criteria volume, velocity, variety, and veracity Real-World Data (RWD): a subset of big data, data relevant to healthcare use and generated from healthcare systems (e.g., EMRs, Claims) Real-World Evidence (RWE): use of cleaned and validated RWD linked by the patient journey to answer questions structured in a scientifically meaningful way to influence R&D, clinical, and commercial decisions 3
4 Big Data is about enabling connectivity between ever-increasing healthcare data sources Driven by the evolution of healthcare technology Wholesale Medical Audit Rxs Longitudinal Patient Records Medical Claims EMR Records Global Data Models, Cross-data integration Genomic Data / Social Media Global Census Zip code level Diagnosis Patient demographics Global Census Physicianlevel Market dynamics Switch, repeat Treatment patterns Quality metrics Pathway cost and performance Genome impact Social media influences Specialty, Outcomes oncology 1954 Now 4
5 Creating value from a patient s point of view RWE turns Big Data into healthcare s most powerful currency via an objective understanding of health outcomes, costs and quality Payer Patient Provider Pharma 5
6 Big Data & RWE value at stake $ Bn 1 US health system Pathway re - design Target disease prevention Coordinated care across providers Payment innovation Clinical decision support Quality measures & performance transparency Re-admissions reduction R&D acceleration Data-driven adherence $1Bn 2 RWE value for major pharmaco 6 1. Centre of US healthcare Reform. McKinsey & Company 2. Breaking new ground with RWE : How Some Pharmacos are Poised to Realize a $1 Billion Opportunity. IMS Health White Paper
7 Practical questions 1. Which RWE applications create $1bn value for life science? 2. What RWE capabilities do companies need to build? 3. How do company RWE transformations happen? 4. What innovations does RWE need to embrace, to give back to overall healthcare system? 7
8 1. RWE applications creating $1bn Development Launch In-market Clinical development* $ m Initial pricing & market access* $100m Launch planning & tracking $150m Safety & value demonstration $ m Commercial spend effectiveness $ m Productivity and cost savings $100m Selected companies already capturing $ m *Selected operational opportunities only; excludes increased R&D pipeline throughput and better pricing 8
9 2. Platform capabilities are required to capture Channels for Dissemination & Engagement RWE capabilities stack CoEs for Scientific & Commercial Analytics Technology-enabled Tools and Analytics Information, Networks, and Data Linkage Business specific setup/build Partially consolidated capabilities/build Consolidated capabilities/buy 9
10 4. RWE innovations and health system contributions Making RWE happen Tech-enabled analytics platforms (beyond SaS & Excel!) Privacy preserving technologies Federated access models / Remote analytics Convergence in research methods: prcts, hybrid prospective-retrospective methods (EMR-eCRF) Predictive analytics RWE contributions to healthcare system Real time Medicines usage (Uptake metrics / utilization) Payment by use / outcomes Adherence programs Commissioning / benefits design: & Patient segmentation Stratified pathways algorithms Expert diagnostic algorithms Expert treatment algorithms 10
11 Today s take-aways RWE a focused approach to unlock Big Value from Big Data Big Data is necessary but not sufficient - Big Data becomes valuable when organizations ask strategic and focused questions, and use information to derive insights Big Data is different from RWD and RWE RWE is a focused and patient-centric approach to Big Data Pharma underutilizes RWE- RWE s patient centric view can unlock up to $1bn of sustained value for pharma, and contribute to health system value RWE Platforms need to address systematic value capture capability builds include innovative information sourcing, technology platforms and consolidated analytical CoEs HEOR has a stake RWE can challenge HEOR & Epi norms, but can also deliver more publications at high impact factor! 11
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