A23: Oncologic Disease- Tumor Markers

Transcription

1 A23: Oncologic Disease- Tumor Markers Diagnosis Tumor Markers and Genetic Markers Use for Specific Malignancy The following information is from multiple guideline sources as recommendations for use of tumor markers and genetic markers. Gastrointestinal Tumor Type Marker Recommended Use Recommending Organizations* Hepatic AFP Monitoring ACS,, ESMO, NACB Early detection in ACS,, ESMO, NACB high-risk patients Helicobacter Environmental risk pylori factor E-Cadherin Risk factor in mutations hereditary forms Pancreatic CA19-9 Monitoring, ESMO, NACB (ductal Diagnosis, NACB adenocarcinoma) Colorectal CEA Monitoring ASCO, NACB, ESMO, Monitoring advanced ASCO, NACB disease Prognosis ASCO, ACS, ESMO,, NACB (if used with other prognostic features) ACS = American Cancer Society, = National Comprehensive Cancer Network, ESMO = European Society of Medical Oncology, ASCO = American Society of Clinical Oncology, NACB = National Academy of Clinical Biochemistry *Organization also searched: American Gastroenterological Association Neuroendocrine Tumor Type Marker Recommended Use All neuroendocrine Chromogranin A Diagnosis tumors (IHC) Recurrence Monitoring Recommending Organizations, ESMO, NACB NACB NACB

2 Synaptophysin Diagnosis (IHC) Prolactin Diagnosis Ki-67 (MIB-1) Diagnosis (IHC) Carcinoid 5-HIAA (urine) Diagnosis, ESMO, NACB Monitoring for, ESMO, NACB specific tumor Serotonin Diagnosis NACB Chromogranin A Diagnosis and (serum, IHC) Gastrin Diagnosis and Pancreatic Diagnosis and polypeptide Gastrinoma Gastrin Diagnosis and, ESMO, NACB Glucagonoma Glucagon Diagnosis and, ESMO, NACB Pheochromocytoma Metanephrines Diagnosis and, ESMO, NACB (plasma, urine) Catecholamines Diagnosis and, ESMO, NACB (urine) Insulinoma Proinsulin Diagnosis and, ESMO, NACB Insulin Diagnosis and C-peptide Diagnosis and Pituitary Growth hormone Diagnosis and, ESMO, NACB IGF-1 Diagnosis and Prolactin Diagnosis and LH/FSH Diagnosis and TSH Diagnosis and Alpha subunit Diagnosis and ACTH Diagnosis and VIPoma VIP Diagnosis and, ESMO, NACB Pancreatic Pancreatic Diagnosis and, ESMO, NACB neuroendocrine polypeptide

3 carcinoma Calcitonin Diagnosis and PTH-related peptide Diagnosis and Somatostatin Diagnosis and = National Comprehensive Cancer Network, ESMO = European Society of Medical Oncology, NACB = National Academy of Clinical Biochemistry Lung Tumor Type Marker Recommended Use Recommending Organizations* Small cell NSE (serum, IHC) Monitoring ACS, NACB (SCLC) Prognosis NACB Chromogranin A Prognosis NACB Non-small cell CEA, SCC Ag Monitoring, NACB, ASCO (NSCLC) prognosis, detecting relapse Mesothelioma Soluble mesothelin Monitoring IMIG, NACB, related peptides (Mesomark ) CK 5,6 Diagnosis CEA Diagnosis WT-1 Diagnosis TTF-1 Diagnosis ACS = American Cancer Society, ASCO = American Society of Clinical Oncology, IMIG = International Mesothelioma Interest Group, NACB = National Academy of Clinical Biochemistry, = National Comprehensive Cancer Network *Organizations also searched: American Thoracic Society (ATS), British Thoracic Society (BTS), American College of Chest Surgeons (ACCP)

4 Female Gynecologic/Genitourinary Tumor Type Marker Recommended Use Recommending Organizations Breast Estrogen, Predict hormone ASCO, ESMO,, NACB progesterone receptor (tissue) response Prognosis ASCO (do not use alone),, NACB (do not use alone), ACS HER, HER2, Predict response to ASCO, ESMO, ACS,, HER-2/neu Herceptin NACB (tissue) Prognosis, NACB Predict response to ASCO,, NACB anthracyclines CA 15-3, CA 27- Monitoring ASCO, ESMO, NACB, ACS 29 advanced disease CEA Monitoring ASCO, NACB advanced disease HER-2/neu Monitoring, NACB prognosis p53 Prognosis NACB Cervical HPV Risk assessment, NACB SCC Ag Monitoring NACB Ovarian CA 125 Monitoring ESMO, NACB, Differential NACB, diagnosis is suspicious pelvic mass Detection of ESMO, NACB, recurrence Prognosis ESMO, NACB βhcg Diagnosis, recurrence Gestational βhcg Monitoring ACS, NACB, trophoblastic Diagnosis ACS, NACB, ASCO = American Society of Clinical Oncology, ESMO = European Society of Medical Oncology, = National Comprehensive Cancer Network, NACB = National Academy of Clinical Biochemistry, ACS = American Cancer Society Male Genitourinary Tumor Type Marker Recommended Use Recommending Organizations* Prostate PSA Screening ACS, AUA, EAU, ESMO, NACB, Staging and prognosis AUA, EAU, ESMO,, NACB Monitoring AUA, EAU, ESMO,, NACB Follow-up and negative, NACB biopsy Germ cell βhcg and Diagnosis and differential ASCO, EAU, ESMO, NACB,

5 (testicular) AFP diagnosis of nonseminomatous germ cell cancer of the testes Staging and prognosis ASCO, EAU, ESMO, NACB, Monitoring ASCO, EAU, ESMO, NACB, Detecting recurrence ASCO, EAU, ESMO, NACB, ACS = American Cancer Society, ASCO = American Society of Clinical Oncology, AUA = American Urological Association, EAU = European Association of Urologists, ESMO = European Society of Medical Oncology, NACB = National Academy of Clinical Biochemistry, = National Comprehensive Cancer Network B-cell and T/NK-cell Lymphoma Tumor Type Marker Recommended Use Recommending Organizations CD3, CD4, CD5, CD10, (BCL-6), Diagnosis and, NACB CD20, CD45 (LCA), CD56CD79a, differentiation CD117 (c-kit), CD138 Cyclin D1, SP4 t(11;14) Diagnosis of MCL and multiple myeloma Ki-67 (MIB-1) Diagnosis HTLV Diagnosis and differentiation = National Comprehensive Cancer Network, ESMO = European Society of Medical Oncology, NACB = National Academy of Clinical Biochemistry Leukemia Tumor Type Marker Recommended Use Recommending Organizations AML c-kit (CD117) Prognosis ESMO = European Society of Medical Oncology, = National Comprehensive Cancer Network, NACB = National Academy of Clinical Biochemistry, WHO = World Health Organization Childhood Tumors Tumor Type Marker Recommended Use Neuroblastoma NSE Prognosis NACB HVA, VMA, Diagnosis, NACB catecholamines Skin Recommending Organizations Tumor Type Marker Recommended Use Recommending Organizations S-100, Diagnosis, usually used ACS, NACB Melanoma HMB45 in combination

6 (gp100) c-kit Response to therapy ACS ACS = American Cancer Society, NACB = National Academy of Clinical Biochemistry Thyroid/Parathyroid Tumor Type Marker Recommended Use Recommending Organizations Thyroglobulin Diagnosis,, AACE, NACB Well-differentiated Thyroglobulin (IHC) Diagnosis NACB Medullary thyroid Calcitonin Monitoring,, AACE, NACB carcinoma diagnosis CEA Diagnosis,, NACB = National Comprehensive Cancer Network, AACE = American Association of Clinical Endocrinologists, NACB = National Academy of Clinical Biochemistry