Marital Status: Married to Kathleen Cole in 1965 Children: Christopher 1966 Elizabeth 1968

Transcription

1 1 CURRICULUM VITAE March 2013 Name: Citizenship: R. John Solaro United States Marital Status: Married to Kathleen Cole in 1965 Children: Christopher 1966 Elizabeth 1968 Home Address and Phone: 1100 North Lake Shore Dr., #35B Chicago, IL (312) Office Address and Phone: Dept. of Physiology & Biophysics (M/C 901) University of Illinois at Chicago College of Medicine 835 S. Wolcott Avenue, Room E-202 MSB Chicago, IL (312) TEL (312) FAX Education: Ph.D., 1971 University of Pittsburgh, School of Medicine Department of Physiology Academic Appointments: 1998-present 1988-present B.Sc., June 1965 University of Cincinnati, College of Pharmacy Distinguished University Professor, University of Illinois Professor and Head, Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine Co-Director UIC Center for Cardiovascular Research Professor, Department of Physiology and Biophysics, University of Cincinnati, College of Medicine Vice-Chairman, Dept. of Physiology and Biophysics, University of Cincinnati, College of Medicine Jan-July 1986 Senior International Fellow of the Fogarty Foundation, Dept. of Physiology, University College, London Professor (Joint Appointment) Department of Pharmacology and Cell Biophysics, University of Cincinnati, College of Medicine Associate Professor, (Joint Appointment) Department of Physiology and Department of Pharmacology and Cell Biophysics, University of Cincinnati, College of Medicine Assistant Professor, Dept Physiology, Medical College of Virginia Instructor, Dept of Physiology, Medical College of Virginia Honorary Research Fellow, Department of Biochemistry, University Birmingham, England (on educational leave from MCV)

2 Honors: Appointed Distinguished University Professor, 1998 Winner of the Annual UIC Graduate Mentoring Award, 2008 MERIT Award, National Heart, Lung and Blood Institute, The 1994 Distinguished Faculty Award, University of Illinois at Chicago, College of Medicine 2006 Nagano Award of the International Academy of Cardiovascular Sciences Philip Hawley Distinguished Faculty Award give by Dept. Students; 1999, 2006, 2010 Inducted into Wadsworth High School Alumni Hall of Fame, 11/2005 Gold Service Award, American Heart Association of Metropolitan Chicago (1994) University Scholar Award, University of Illinois at Chicago ( ) Biophysical Society Chair Public Affairs Committee ( ) Biophysical Society Council ( ) Assoc. of Chairs of Departments of Physiology (Pres-Elect & President ) Assoc. of Chairs of Departments of Physiology (Secretary/Treasurer ) Secretary-General, International Society for Heart Research ( ) Secretary, International Society for Heart Research - American Section (1994) Cardiac Muscle Society (Secretary/Treasurer, ; President, ) Listed in Who s Who in the World 2002 Chair Gordon Research Conference: Cardiac Regulatory Mechanisms. Founding Fellow of the International Society for Heart Research Fellow of the American Heart Association Inaugural Fellow of the AHA Council on Basic Cardiovascular Sciences Member at Large, Executive Committee of the Basic Cardiovascular Sciences Council of the American Heart Association ( ) Executive Committee of the Basic Science Council, American Heart Association ( ) Elected to the Council, Intern. Soc. Heart Research, American Section ( ; ) Fellow of the Council on Circulation, American Heart Association Amer. Physiol. Society, Chairman of Cardiac Muscle Steering Committee of the Myo-Bio Group ( ); Member ( ) Senior International Fellowship of the Fogarty Foundation (Jan.-July, 1986) Biophysical Society, Chairman, Contractility Subgroup ( ) Research Career Development Award of the NIH, Established Investigator Grant of the American Heart Association, 1977 (Declined) British-American Heart Fellowship of the American and British Heart Foundations,

3 3 CURRENT SUPPORT: RO1 HL (33-36) (Multiple PI 08/01/11-07/31/ cal Solaro/Gupta) NIH/NHLBI $250,000/yr Modulation of Calcium Control of Cardiac Myofibrils Major Goals: The proposal focuses on the micro-rna control mechanisms in isoform switching of troponin I in the heart. PO1 HL (11-15) (Solaro) 06/01/10-05/31/ cal NIH/NHLBI $1,730,101/yr Integrated Mechanisms of Cardiac Maladaptation Major goals: This program project addresses the mechanisms of processes triggered by stresses on the heart that are adaptive and offset the sress or maladaptive and exacerbate the stressor leading to decompensation. There are 4 projects and 3 cores. NIH R01 HL64035 (11-14) (Multi PI: 01/01/10-12/31/ cal Solaro/Wolska) NIH/NHLBI $250,000/yr Troponin Modulation in Heart Failure Major goals: This project investigates the role of p21 activated kinase in control of contractility and explores the hypothesis that altered myofilament response to Ca 2+ is a therapeutic approach to dialted and hypertrophic cardiomyopathies NIH T32 HL07692 (20-25) (PI: Solaro) 07/01/10-06/30/15 NIH/NHLBI $664,942/yr Cellular Signaling in the Cardiovascular System Failure Major goals: Training program with 7 pre-doc and 7 post-doc slots to provide investigators with the background training and skills to advance knowledge related to the understanding, prevention, and treatment of cardiovascular disease. Medical Research Council Great Britain G (Ming Lei, MD, PhD PI; Co-PI Solaro) Cardiac electrical function, Ca 2+ sensitivity and arrhythmogenesis in mice with genetic modifications of PAK1 $135, NIH RO1HL (01-04) (PI: Lewandowski $531,478/yr Co-PI: R. J. Solaro Gender Effects on Remodeling of Lipid and Sarcomere Dynamics in Hypertrophy

4 4 Editorial Boards/Advisory Committees: Associate Editor, J Mol Cell Cardiology (2007-present) Consulting Editor, Am J Physiology: Heart and Circulatory Physiology ( ) Guest Editor: J Mol Cell Cardiol Special issue on the Cardiac Sarcomere (2010) Guest Editor. J Biol Chem Focused Minireview: Signaling in Cardiac Sarcomeres (2010) Guest Editor, Cardiovascular Research, Special issue on the Cardiac Sarcomere, (2008) Guest Editor: Circulation Research Special Series: Reg Signaling by Thin Filament Proteins (2004) Guest Editor: Basic Research in Cardiology Review Focus Series on the Sarcomere (2008) Co-Editor (with H. Fozzard and E. Page), Handbook of Physiology, The Heart Board of Directors, Proteomics and Informatics Section: Chicago Biomedical Consortium Editorial Board, Circulation Research ( ; 1994-present) Editorial Board, J. Biological Chemistry ( ; ) Editorial Board, J. Molecular and Cellular Cardiology ( ) Editorial Board, Science Magazine, inscight (1998-present) Associate Editor, American J. Physiol. Heart and Circulatory Physiology ( ; ) Editorial Board, J. Pharmacology and Therapeutics (1988-present) Editorial Board, Molecular and Cellular Biochemistry ( ) Editorial Board, Current Cardiology Reviews (2004-present) Associate Editor, News in Physiological Sciences ( ) Editorial Board, J. Clinical Investigation ( ) Editorial Board, International Society for Heart Research, Heart News and Views ( ) Editorial Board, Doody's Health Sciences Review Journal ( ) Editorial Board, American Journal of Physiology: Cell ( ) Full Member and Chair Skeletal Muscle/Exercise Physiology Study Section ( ) NHLBI Board of Scientific Counselors (ad hoc member 2001) Chair, NHLBI, NRSA Institutional Training Grant Review Committee (2000, 2001) Chair, NHLBI, Special Review Panel on Cardiac Resuscitation (2002) Scientific Advisory Board, Cytokinetics, Inc. APS Joint Program Committee ( ) Review Panel Texas Advanced Technology Program (1997; 2003) Public Affairs Committee, American Physiological Society ( ) Full Member, VA Merit Review Committee ( ) Ad Hoc Committee on Local APS Organizations, American Physiological Society (1993) Full Member, National AHA Review Committee ( ) Chair Research Council, AHA-Metropolitan Chicago ( ) Chairman, NIH Experimental Cardiovascular Sciences Study Section ( ) Vice-Chair Research Council, AHA-Metropolitan Chicago ( ) Council Member and Chair, Program Committee, International Society for Heart Research - North American Section ( ) AHA Metropolitan Chicago Review Committee ( ) New York Heart Association Grant Review Committee (1989) Full Member, NIH, Experimental Cardiology Study Section ( ) Full Member, NIH, Physiology Study Section ( ) Full Member, NSF, Cellular Physiology Study Section (12/82-6/83) Full Member, NIH, Clinical Sciences Study Section ( ) Ad Hoc NIH, Cardiopulmonary B Study Section Ad Hoc NIH, Research Manpower Review Committee Ad Hoc Committee, American Physiological Society, Review of Educational Films

5 5 Membership in Scientific, Honorary and Professional Societies: American Physiological Society American Society for Biochemistry and Molecular Biology International Society for Heart Research (Secretary General; Council Member) American Association for the Advancement of Science Biophysical Society (Council Member ; Chair Public Affairs Committee ) Cardiac Muscle Society (Past President) Association of Chairs of Departments of Physiology (Past President) American Heart Association Council on Basic Cardiovascular Sciences Phi Eta Sigma (Freshman Honor Society) Rho Chi (National Pharmacy Honor Society) College of Medicine/University Committees: Chair Search Committee Regional Dean, UIC College of Medicine at Urbana Champaign Search Committee for Section Head, Division of Cardiology ( ) Chair Search Committee for UIC Provost & Vice-Chancellor for Academic Affairs ( ) M.D./Ph.D. Executive Committee/Steering Committee (1996-present) College of Medicine Executive Committee Full Member ( ) Alternate (l988-89; ) Chair, Chancellor s Committee on Organization of the Health Sciences Center (2004-5) Search Committee, Vice-Dean for Research, College of Medicine (2004-5) Chair, Provost Search Committee, Univ. of Illinois at Chicago ( ) Chair, Distinguished University Professor Review Panel (2000; 2001) Chair, College of Medicine, Committee on Faculty Awards ( ) Distinguished Faculty Award Subcommittee ( ) Chair, College of Medicine, IRB Priorities Committees ( ) Chair, Search Committee for Head of Pathology ( ) Search Committee, Section Chief, Division of Cardiology (1996) Chair, Chancellor Search Committee, Univ. of Illinois at Chicago ( ) Radiation Safety Committee (1995-present) Search Committee, Head of Bioengineering (1995) Search Committee, Dean, College of Pharmacy ( ) Search Committee, Head of Biological Sciences ( ) Search Committee, Vice-Chancellor for Research/Dean of the Graduate College ( ) Research Resources Center Advisory Committee ( ) Chair, Facilities Committee, LCME Report (1994) College of Medicine Strategic Planning Committee (1993) College of Medicine Medical Student Processional and Convocation Committee ( ) Task Force on Hospital Affiliations ( ) College of Medicine, Committee on Committees ( ); ( ); ( ); ( ) Chair, Search Committee for Head, Department of Pharmacology ( ) Search Committee, Chancellor, University of Illinois at Chicago (1991) Search Committee, Vice Chancellor for Academic Affairs (1991) Chair, Search Committee, Head of Oral Biology, College of Dentistry ( ) University Senate, College of Medicine Delegate (1990) Chair, Search Committee, Chief, Hematology/Oncology ( ) Search Committee for Head of the Department of Medicine (1989) Search Committee for the Executive Associate Dean of the Graduate College (1989) Hospital Rebuilding Committee (l989) Task Force for Master Affiliation Agreements (l989)

6 6 Post-Docs, Research Faculty and Visiting Scientists: Current: Paul Mungai, PhD, Post-Doctoral Fellow (2012-Present) Niambe Scruggs, MD Post-Doctoral Fellow (2011-present) Michelle Monasky, PhD, Post-Doctoral Fellow (2010-present) F32 Awardee Marcus Henze, PhD, Post-Doctoral Fellow (2009-present) Yunbo Ke, PhD, Post-Doctoral Fellow; Research Assistant Professor, 2001-present, MRC Grant Awardee, CCTS Grant Awardee. Tomoyoshi Kobayashi, PhD Research Associate Professor, 2001-Present, AHA Scientist Development Grant Awardee ( ); RO1 Awardee ( ). Madhu Gupta, PhD. Research Associate Professor 2010-Present. MPI RO1 HL22231 Past: Ivana Knesevic, PhD, Post-Doctoral Fellow ( ) Mariam Farjah, PhD, Research Assistant Professor Katherine Sheehan, PhD, Post-Doctoral Fellow ( ) NRSA Awardee; Research Assistant Professor (2008). Brandon Biesiadecki, PhD, Post-Doctoral Fellow ( ) NRSA Awardee, K99/ROO Awardee; Research Assistant Professor Aaron Hinken, PhD, :Post Doctoral Fellow; Research Assistant Professor ( ) NRSA Awardee Chao Yuan, PhD, Post Doctoral Fellow, ( ) Dalia Urbonene, MD, PhD, Post Doctoral Fellow, Res Assistant Prof Amelia Sumandea, PhD, Post-Doctoral Fellow ( ) NRSA Awardee Aicha Bouhel, PhD, Post-Doctoral Fellow ( ) Marius Sumandea, Ph.D., Post-Doctoral Fellow, ; Research Assistant Professor NRSA Award ;AHA Scientist Development Grant Awardee ( ). Grace Arteaga, M.D., Assistant Professor; MIRS Fellow, , Clinician Scientist Awardee 2001-present Huashan Huang, PhD, Post-Doctoral Fellow Lynn Wang (Formerly Lin Huang), MD, PhD, Post-Doctoral Fellow, ; Research Assistant Professor ( ) Temanas Bupha-Inter DVM, Thailand Golden Jubilee Visiting Scientist, Stephen Smith, PhD., Post-Doctoral Fellow, NRSA Awardee Glen Pyle, Ph.D., Post-Doctoral Fellow, AHA Post-Doc Fellowship Jose Puglisi, Ph.D., Post-Doctoral Fellow, ; AHA Awardee Murali Chandra, Ph.D., Post-doctoral Fellow, ; Res Asst Professor, AHA Post-Doc Fellowship Ronald Phillips, Ph.D., Post-doctoral Fellow, NRSA Award Helen Rarick, Ph.D., Post-doctoral Fellow, ; Res Assistant Professor, NRSA Award Rebecca Keller, Ph.D., Post-doctoral Fellow, Jenifer Van Eyk, PhD Post-Doctoral Fellow Beata Wolska, Ph.D., Post-doctoral fellow, ; Research Assistant Professor, AHA Post-Doc Fellowship; AHA Grant in Aid Hiroaki Minami, M.D., Ph.D., Post-doctoral Fellow, Lesa Fraker, M.D., Ph.D. (Assistant Professor), Yoshimi Kitada, Ph.D., Post-doctoral Fellow, Vera Averyhart-Fullard, Ph.D. (Research Assistant Professor), MIRS Award

7 7 Frances Powers, Ph.D., Post-doctoral Fellow, NRSA Award Xiaodu Guo, M.D., Ph.D., Post-doctoral Fellow, NRSA Award Kenneth Bizovi, M.D. (Research Fellow), Abid Mahmood, M.D., Research Fellow, Margaret Westfall, Ph.D., Post-doctoral Fellow, NRSA Award Atsushi Kawamura, M.D., Ph.D., Post-doctoral Fellow, Tetsuo Takayasu, M.D., Ph.D., Post-doctoral Fellow, Saleh El-Saleh, Ph.D., Post-doctoral Fellow, Ann Murphy, M.D., Post-doctoral Fellow, Kazuya Fujino, M.D., Ph.D. Post-Doctoral Fellow, Deborah Lieberman, Ph.D., Research Associate, Stephan Rapundalo, Ph.D., Post-doctoral Fellow, NRSA Award Pankaj Kumar, M.D., Post-doctoral Fellow, Ullrich Quast, Ph.D., Visiting Scientist, 1984 Michael Holroyde, Ph.D., Post-doctoral Fellow, R.D. Srivastava, M.D., Post-doctoral Fellow, Pascal Bousquet, M.D., Visiting Scientist, 1983 Takako Fujiwara, M.D., Ph.D., Visiting Scientist, 1982 Joachim W. Herzig, Ph.D., Visiting Scientist, 1982 Grant Pierce, Ph.D., Visiting Scientist, 1982 Advisor to following Graduate Students: Current: Sumeyye Yar, MSc, PhD Candidate, Department of Biochemistry and Molecular Genetics, University of Illinois at Chicago, College of Medicine (AHA Pre-Doctoral Felllowship) Jillian Simon, PhD Candidate, Co-Advisor with Beata Wolska, PhD; Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine (AHA Pre-Doctoral Felllowship) Tanganyika Wilder, Ph.D. Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine (APS Porter Fellowship) Past: Domenico Taglieri, MD. Ph.D. PhD 2011 Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine (University Fellowship; Deans Dissertation Award) Benjamin Avner, MD, PhD Candidate, Ph.D Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine (AHA Pre-Doctoral Fellowship) Chehade (Eddie) Karam Ph.D Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine (AHA Pre-Doctoral Fellowship) Rmeileh, Amin M., MSc, Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine. Sarah Scruggs, PhD., 2009 Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine (AHA Pre-Doctoral Fellowship) Steven Wu, Ph.D. (2007), Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine (Dean s Dissertation Award) (AHA PreDoc Fellowship Award)

8 8 Theressia Washington, MD, MSc, Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine (MIRS Award to RO1 HL 22231) Patti Engel, Ph.D., Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine (AHA PreDoc Fellowship Award) Susan Vahebi, MSc. Ph.D. 2005, Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine (AHA PreDoc Fellowship Award) UIC Outstanding Thesis Award. Eileen Burkart,, Ph.D. 2003, Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine (AHA Pre Doc Fellowship Award) Andrew Germanovich, MSc 2003, Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine. Ge Li, MD. PhD 2001, Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine. John P. Konhilas, Ph.D. 2001, Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine (Co-Advisor with Pieter detombe, PhD) David E. Montgomery, Ph.D. 2001, Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine (Abraham Lincoln Fellowship) Christian Evans, Ph.D. 2000, Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine UIC Outstanding Thesis Award. Miroslav Stojanovic, MD, Ph.D. Candidate, Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine (Deceased) Haiping Tang, M.S. 1998, Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine Kimberly Palmiter, Ph.D. 1996, Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine. UIC Outstanding Thesis Award. Jonggonnee Wattanapermpool, Ph.D. 1994, Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine Karen Ball, Ph.D. 1994, Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine Lizhu Gao, Ph.D. 1993, Department of Physiology and Biophysics, University of Illinois at Chicago, College of Medicine (Co-Advisor with John Kennedy, PhD) Lynda Dieckman, Ph.D. 1990, Department of Physiology, University of Cincinnati College of Medicine Bo Sheng Pan, Ph.D. 1987, Department of Physiology, University of Cincinnati College of Medicine Edward Blanchard, Ph.D. 1983, Department of Physiology, University of Cincinnati College of Medicine Edward Pagani, PhD, 1982, Department of Physiology, Ph.D., University of Cincinnati College of Medicine John S. Shiner, Ph.D. 1978, Department of Physiology, Medical College of Virginia

9 9 Publications of R. John Solaro: Papers: Buckley, J.P., Solaro, R.J. and H. Barry. (1969) Effects of Phenformin HCl on rats subjected to simulated high altitude. J. Pharm. Sci. 58: Solaro, R.J., Pang, D.C., and F.N. Briggs. (1971) The purification of cardiac myofibrils with Triton X-100. Biochim. Biophys. Acta 245: Briggs, F.M., Solaro, R.J. and E.W. Gertz. (1971) Estimation of the amount of sarcoplasmic reticulum in cardiac muscle. In: Cardiac Hypertrophy. N.R. Albert, ed., Academic Press, New York pp Solaro, R.J., Gertz, E.W. and F.N. Briggs. (1972) Sucrose antagonism of drug and temperature effects on cardiac sarcoplasmic reticulum. Biochim. Biophys. Acta 255: Solaro, R.J. and F.N. Briggs. (1974) Calcium conservation and E-C coupling in the heart. In: Myocardial Biology: Recent Advances in Studies on Cardiac Structure and Metabolism. Vol. 4, University Park, Baltimore pp Hess, M.L., Solaro, R.J. and F.N. Briggs. (1974) Polyhydroxyl and temperature antagonism of the inhibitory effects of gram negative endotoxin on the calcium uptake activity of cardiac sarcoplasmic reticulum. In: Myocardial Biology: Recent Advances in Studies on Cardiac Structure and Metabolism. Vol. 4, University Park, Baltimore pp Solaro, R.J. and F.N. Briggs. (1974) Calcium and control of enzymatic and mechanical activity in muscle. In: Calcium Binding Proteins. W. Drabikowski, ed., Elsevier Publishing Co., Amsterdam pp Solaro, R.J., Wise, R.M., Shiner, J.S. and F.N. Briggs. (1974) Calcium requirements for cardiac myofibrillar activation. Circ. Res. 34: Solaro, R.J. and F.N. Briggs. (1974) Estimating the functional capabilities of sarcoplasmic reticulum in cardiac muscle: Calcium binding. Circ. Res. 34: Solaro, R.J. (1974) Calcium regulation of cardiac myofibrillar activation: Effects of MgATP. J. Supramol. Struct. 3: Briggs, F.N. and R.J. Solaro. (1976) The role of calcium and magnesium in contraction of muscle fibers. In: Metal Ions in Biological Systems. Vol. 6, Helmut Sigel, ed., Marcel Dekker, Inc., New York pp Solaro, R.J. and J.S. Shiner. (1976) Modulation of Ca ++ control of dog and rabbit cardiac myofibrils by Mg ++ : Comparison with rabbit skeletal myofibrils. Circ. Res. 39: Frearson, N., Solaro, R.J. and S.V. Perry. (1976) Changes in phosphorylation of the P light chain of myosin in the perfused rabbit heart. Nature 264: Solaro, R.J., Moir, A.J.G. and S.V. Perry. (1976) Phosphorylation of troponin I and the inotropic effect of adrenalin in the perfused rabbit heart. Nature 262: Solaro, R.J., Bruni, F.D. and E.N. Gleason. (1976) Effects of ionic strength on calcium binding to rabbit skeletal myofibrils, thin filaments and myosin. Biochim. Biophys. Acta 449: Solaro, R.J. and F.N. Briggs. (1977) Calcium oxalate transport as a measure of sarcoplasmic reticulum function. In: Methodological Surveys in Biochemistry, Vol. 6. Membranous Elements and Movement of Molecules. Eric Reid, ed., Wiley Ltd., Chichester, U.K. pp

10 Briggs, F.N., Shiner, J.S., Gleason, E.N., Bruni, F. and R.J. Solaro. (1977) Calcium binding and cardiac myofibril activation. In: Myocardial Failure. G. Riecker et al., eds., Springer-Velag, Berlinpp. pp Briggs, F.N., Poland, J.L. and R.J. Solaro. (1977) Relative capabilities of sarcoplasmic reticulum in fast and slow mammalian skeletal muscle. J. Physiol. (Lond.) 266: Litten, R.Z., Solaro, R.J. and G.D. Ford. (1977) Properties of the calcium sensitive components of bovine arterial actomyosin. Arch. Biochem. Biophys. 182: Perry, S.V., Cole, H.A., Frearson, N., Moir, A.J.G., Nairn, A.C. and R.J. Solaro. (1978) Phosphorylation of the myofibrillar proteins. In: Cyclic Nucleotides in Cell Regulation. A. Wollenberger, E.G. Krause and L. Pinna, eds., Vol. 54, Pergamon Press, New York pp Cole, H.A., Frearson, N., Moir, A.J.G., Perry, S.V. and R.J. Solaro. (1978) Phosphorylation of the cardiac myofibrillar proteins. In: Myocardial Biology: Recent Advances in Studies on Cardiac Structure and Metabolism. University Park, Baltimore 11 pp Litten, R.Z., Solaro, R.J. and G.D. Ford. (1979) Nature of the calcium regulatory system of bovine arterial actomyosin. Blood Vessels 16: Holroyde, M.J., Potter, J.D. and R.J. Solaro. (1979) The calcium binding properties of phosphorylated and unphosphorylated cardiac and skeletal myosins. J. Biol. Chem. 254: Holroyde, M.J., Howe, E. and R.J. Solaro. (1979) Modification of calcium requirements for activation of cardiac myofibrillar ATPase by camp dependent phosphorylation. Biochim. Biophys. Acta 586: Holroyde, M.J., Small, D.A.P., Howe, E. and R.J. Solaro. (1979) Isolation of cardiac myofibrils and myosin light chains with in vivo levels of light chain phosphorylation. Biochim. Biophys. Acta 587: Wang, T., Tsai, L.I., Solaro, R.J., Grassi de Gende, A.O. and A. Schwartz. (1979) Effects of potassium on vanadate inhibition of sarcoplasmic reticulum Ca 2+ - ATPase from dog cardiac and rabbit skeletal muscle. Biochem. Biophys. Res. Commun. 91: Solaro, R.J., Holroyde, M.J., Wang, T., Matlib, A., Grupp, G. and A. Schwartz. (1980) Effects of vanadate on biochemical and contractile properties of rabbit hearts. J. Cardiovasc. Pharm. 2: Solaro, R.J., Holroyde, M.J., Herzig, J.W. and J. Peterson. (1980) Cardiac relaxation and myofibrillar interactions with phosphate and vanadate. Eur. Heart J. 1: Moir, A.J.G., Solaro, R.J. and S.V. Perry. (1980) The site of phosphorylation of TnI in the perfused rabbit heart: The effect of adrenaline. Biochem. J. 185: Schwartz, A., Adams, R.J., Grupp, I., Grupp, G., Holroyde, M.J., Millard, R.W., Solaro, R.J. and E.T. Wallick. (1980) Effects of Vanadate on myocardial function. Basic Res. Cardiol. 75: Holroyde, M.J., Roberston, S.P., Johnson, J.D., Solaro, R.J. and J.D. Potter. (1980) The Ca 2+ and Mg 2+ binding sites on cardiac troponin and their role in the regulation of adenosine triphosphatase. J. Biol. Chem. 255: Solaro, R.J., Robertson, S.P., Johnson, J.D., Holroyde, M.J. and J.D. Potter. (1981) TnI Phosphorylation: A unique regulator of the amounts of Ca 2+ required to regulated cardiac myofibrils. Cold Spring Harbor Symp. Protein Phosphorylation 8:

11 Shiner, J.S. and R.J. Solaro. (1981) The effects of modifiers on enzyme catalysis. A non-classical nearest neighbor approach. Biophys. Chem. 13: Herzig, J.W., Peterson, J.W., Ruegg, J.C. and R.J. Solaro. (1981) Vanadate and phosphate ions reduce tension and increase cross-bridge kinetics in chemically skinned heart muscle. Biochem. Biophys. Acta 672: Litten, R.Z., Martin, B.J., Alpert, N., Howe, E.R. and R.J. Solaro. (1981) Phosphorylation and ATPase of myofibrils from thyrotoxic rabbit hearts. Circ. Res. 48: Silver, P.J., Holroyde, M.J., Solaro, R.J. and J. Disalvo. (1981) Calmodulin, calcium and cyclic AMP dependent modulation of aortic actin-myosin interactions. Biochim. Biophys. Acta 674: Johnson, J.D., Crouch, T.C., Holroyde, M.J., Solaro, R.J. and J.D. Potter. (1981) Fluorescence studies on calmodulin-myosin light chain kinase interactions. J. Biol. Chem. 256: Crouch, T.C., Holroyde, M.J., Johnson, J.D., Collins, J., Solaro, R.J. and J.D. Potter. (1981) Interactions between calmodulin and myosin light chain kinase of skeletal muscle. Biochemistry 20: Potter, J.D., Holroyde, M.J., Robertson, S.P., Solaro, R.J. and J.D. Johnson. (1982) The regulation of cardiac muscle contraction by troponin. In: Cell and Muscle Motility, Vol. 2, R.M. Dowben and J.W. Shay, eds., Plenum Publ. Co., New York, pp Robertson, S.P., Johnson, J.D., Holroyde, M.J., Kranias, E., Potter, J.D. and R.J. Solaro. (1982) The effect of TnI phosphorylation on static and kinetic Ca binding by cardiac TnC. J. Biol. Chem. 257: Martin, A., Pagani, E.D. and R.J. Solaro. (1982) Thyroxine induced redistribution of isoenzymes of rabbit ventricular myosin. Circ. Res. 50: Shiner, J.S. and R.J. Solaro. (1982) The activation of thin filament regulated muscle by calcium ion: Considerations based on nearest neighbor lattice statistics. Proc. Nat. Acad. Sci., U.S.A. 79: Solaro, R.J. and J.C. Ruegg. (1982) Stimulation of Ca 2+ binding and ATPase activity of dog cardiac myofibrils by ARL 115BS, a novel cardiotonic agent. Circ. Res. 51: Kranias, E.G. and R.J. Solaro. (1982) Phosphorylation of TnI and phospholamban during catecholamine stimulation of rabbit hearts. Nature 298: Solaro, R.J. (1982) The role of calcium in the contraction of the heart. In: Calcium Blockers: Mechanism of action and clinical applications, (Flaim, S.F. and Zelis, R. eds.,) Urban and Schwartzenberg. pp Herzig, J.W., Peterson, J.W., Solaro, R.J. and J.C. Ruegg. (1982) Phosphate and vanadate reduce the efficiency of the chemo-mechanical energy transformation in cardiac muscle. In: Regulation of Phosphate and Mineral Metabolism. pp , (Massey, Letteri and Ritz, eds.) Plenum Pub. Corp. New York. 47. Solaro, R.J., Disalvo, J. and R.J. Paul. (1983) Coordination of metabolism and contractility by phosphorylation in cardiac, skeletal and smooth muscle. Introduction Fed. Proc. 42: Kranias, E.G. and R.J. Solaro. (1983) Coordination of cardiac SR and myofibrillar function by protein phosphorylation. Fed. Proc. 42: Litten, R.Z., Martin, B.J., Low, R.B., Solaro, R.J. and N.R. Alpert. (1983) Structural alterations in contractile proteins from thyrotoxic and pressure overloaded hypertrophied rabbit heart. In: Myocardial Hypertrophy and Failure, N. Alpert ed., Raven Press, N.Y. pp Solaro, R.J., Martin, A.F. and E.D. Pagani. (1983) The activity and regulation of myofibrils during long term stresses on the heart. In: Myocardial Hypertrophy and Heart Failure, N. Alpert, ed., Raven Press, N.Y. pp

12 Kranias, E.G. and R.J. Solaro. camp dependent phosphorylation and beta- adrenergic stimulation of hearts. Biomedicine and Pharmacotherapy NEWS. 2 Feb., Pagani, E.D. and R.J. Solaro. (1983) Thyroid state, cardiac myosin isoenzymes and swimming exercise in rat. Am. J. Physiol. 245 (Heart, Circ. Physiol.) :H713-H Imai, K., Wang, T., Millard, R.W., Ashraf, M., Kranias, E.G., Asana, G., Solaro, R.J. and A. Schwartz. (1983) Ischemia induced changes in canine sarcoplasmic reticulum. Cardiovasc. Res. 17: Herzig, J.W., Bothelo, L.H. and R.J. Solaro. (1983) Modification of the Ca 2+ requirement for cardiac myofibrillar activation - a cardiotonic principle? Proceed. Internat. Symposium on Contractile Proteins. Sardinia Italy Pagani, E.D. and R.J. Solaro. (1984) Methods for measuring functional properties of sarcoplasmic reticulum and myofibrils in small samples of myocardium. Methods in Pharmacology (A. Schwartz, ed.) Vol. 5, Plenum Publishing Corp., N.Y. pp Blanchard, E.M., Pan, B.-S. and R.J. Solaro. (1984) The effect of acidic ph on the ATPase activity and troponin Ca 2+ binding of rabbit skeletal myofilaments. J. Biol. Chem. 259: Blanchard, E.M. and R.J. Solaro. (1984) Inhibition of the activation and troponin Ca 2+ binding of dog cardiac myofibrils by acidic ph. Circ. Res. 55: Shiner, J.S. and R.J. Solaro. (1984) The Hill coeffecient for the Ca 2+ activation of striated muscle contraction. Biophys. J. 46: Pagani, E.D. and R.J. Solaro. (1984) Co-ordination of cardiac myofibrillar and sarcotubular activities in rats exercised by swimming. Am J. Physiol. 247: Kranias, E.G., Garvey, J.L., Srivastava, R.D. and R.J. Solaro. (1985) Phosphorylation and functional modifications of sarcoplasmic reticulum and myofibrils in isolated rabbit hearts stimulated with isoproterenol. Biochem. J. 226: Li, T., Sperelakis, N., TenEick, R.E. and R.J. Solaro. (1985) Effects of diacetyl monoxime (DAM) on cardiac excitation-contraction coupling. J. Pharm. Exp. Ther. 232:

13 Solaro, R.J. and J.L. Garvey. (1985) Myofilament protein phosphorylation and neural regulation of cardiac contractility. Pathobiology of Cardiovascular Injury (Stone, H.L. and Veglicki, W.B., eds.), M. Nijhoff Pub., Boston, pp Solaro, R.J., Kumar, P., Blanchard, E.M. and A.M. Martin. (1986) Differential effects of ph on Ca 2+ activation of myofilaments of adult and perinatal dog hearts: Evidence for developmental differences in thin filament regulation. Circ. Res. 58: Solaro, R.J. (1986) Overview of the role of Ca 2+ and protein phosphorylation in contraction of the heart. In: Protein Phosphorylation in Heart (Solaro, R.J. ed.) CRC Press, Inc., Boca Raton, pp Solaro, R.J. (1986) Protein phosphorylation and the cardiac myofilaments. In: Protein Phosphorylation in Heart (Solaro, R.J., ed.) CRC Press, Inc., Boca Raton, pp Rouslin, W.R., Erickson, J.L. and R.J. Solaro. (1986) Effects of oligomyosin and acidosis on rates of ATP depletion in ischemic heart muscle. Am. J. Physiol. 250:H503-H Williams, J.S., Solaro, R.J. and A. Schwartz. (1986) The role of calcium in cardiovascular diseases. In: Treatment of Cardiovascular Diseases by Adalat (Krebs, R., ed.) Schattauer, Stuttgart, New York, pp. 3-23,. 68. Rapundalo, S.T., Grupp, I., Grupp, G., Matlib, M.A., Solaro, R.J. and A. Schwartz. (1986) Myocardial actions of milrinone: characterization of its mechanism of action. Circulation 73(Suppl.III): Solaro, R.J., Bousquet, P. and J.D. Johnson. (1986) Stimulation of cardiac myofilament force, ATPase activity and troponin C Ca 2+ -binding by bepridil. J. Pharm. Exp. Ther. 238: El-Saleh, S., Potter, J.D. and R.J. Solaro. (1986) Alteration of actin-troponin interaction in 2,4-pentanedione treated rabbit skeletal myofibrils. J. Biol. Chem. 261: Solaro, R.J., Rapundalo, S.T., Garvey, J.L. and E.G. Kranias. (1987) Mechanics of cardiac contraction and the phosphorylation of sarcotubular and myofilament proteins. In: Mechanics of the Circulation (H.E.D.J. terkeurs and J.V. Tyberg, eds.), Martinus Nijhoff Publishers, Boston, Lancanster, Dordrecht, pp Pan, B.-S. and R.J. Solaro. (1987) Calcium binding properties of troponin C in detergent skinned heart muscle fibers. J. Biol. Chem. 262: El-Saleh, S. and R.J. Solaro. (1987) Calmidazolium, A calmodulin antagonist, stimulates Ca-calmodulin and Ca-troponin C dependent activation of striated myofilaments. J. Biol. Chem. 262: Whitmer, J., Kumar, P. and R.J. Solaro. (1988) Calcium transport properties of cardiac sarcoplasmic reticulum from cardiomyopathic syrian hamsters (Bio and 14.6): Evidence for a quantitative defect in dilated myopathic hearts not evident in the hypertrophic hearts. Circ. Research 62: Garvey, J.L., Kranias, E.G. and R.J. Solaro. (1988) Phosphorylation of C- proteins, troponin I and phospholamban in isolated rabbit hearts. Biochem. J. 249: El-Saleh, S. and R.J. Solaro. (1988) Troponin I enhances acidic ph induced depression of Ca-binding to the regulatory sites in skeletal troponin C. J. Biol. Chem. 263: Jakab, G., Rapundalo, S.T., Solaro, R.J. and E.G. Kranias. (1988) Phosphorylation of phospholipids in isolated guinea pig hearts stimulated with isoprenaline. Biochem. J. 251: Solaro, R.J. Lee, J., Kentish, J. and D.A. Allen. (1988) Differences in the response of adult and neonatal heart muscle to acidosis. Circ. Res. 63:

14 Fujino, K., Sperelakis, N. and R.J. Solaro. (1988) Sensitization of dog and guinea pig cardiac myofilaments to Ca 2+ -activation and inotropic effect of pimobendan: Comparison with milrinone. Circ. Research. 63: Solaro, R.J. and B-S. Pan. (1988) Control and modulation of contractile activity of cardiac myofilaments. In: Physiology and Pathophysiology of the Heart. Second Edition. (N. Sperelakis, ed.) Kluwer Academic Publishers, pp Fujino, K., Sperelakis, N. and R.J. Solaro. (1988) Differential effects of d- and l-pimobendan on cardiac myofilament calcium sensitivity. J. Pharm. Exp. Ther. 247: Rapundalo, S.T., Solaro, R.J. and E.G. Kranias. (1989). Positive inotropic effects of isoproternol and phosphodiesterase inhibitors on guinea pig hearts: Comparison of camp levels and sarcoplasmic reticulum and myofibrillar phosphorylation. Circ. Research 64: Solaro, R.J., S.C. El-Saleh, J. Kentish, A. Meyer and A. Martin. (1989) Transitions in isoform populations of thick and thin filament proteins and calcium activation of force and ATP hydrolysis by cardiac myofilaments. In: Muscle Energetics (R.J. Paul, G. Elzinga, K. Yamada, eds.) Alan R. Liss, Inc, New York, Solaro, R.J., S.C. El-Saleh, J.C. Kentish (1989) Ca 2+, ph and the regulation of cardiac myofilament force and ATPase activity. Molecular and Cellular Biochemistry 89: Herzig, J.W., L.H. Bothelho and R.J. Solaro. (1989) Myofibrillar Ca 2+ -activation and heart failure - Ca 2+ sensitization by the cardiotonic agent APP Basic Research Cardiol. 84 (Suppl. 1) Solaro, R.J., K. Fujino, and N. Sperelakis. (1989) The positive inotropic effect of pimobendan involves stereospecific increases in the calcium sensitivity of cardiac myofilaments. J. Cardiovasc. Pharm. 14 (Suppl. 2) S7-S Fujino K, Sperelakis N, Solaro RJ. (1989) Direct effects of pimobendan on cardiac myofilaments. Prog Clin Biol Res.;315: Just, H. and Solaro, R.J. (1989) Pharmacotherapy of congestive heart failure: A new approach in inotropic stimulation. Introduction. J. Cardiovasc. Pharm. 14 (Suppl. 2) S Edes, I., Solaro, R.J. and E.G. Kranias. (1989) Changes in phosphoinositide turnover in isolated guinea pig hearts stimulated with isoproterenol. Circ. Research 65: McAuliffe, J.J., Gao, L, and Solaro, R.J. (1990) Changes in myofibrillar activation and troponin C Ca 2+ -binding associated with troponin T isoform switching in developing rabbit heart. Circ. Research 66: Dieckman, L.J. and Solaro, R.J. (1990) The effects of thyroid status on thin filament Ca 2+ - regulation and expression of troponin I isoforms in perinatal and adult rat hearts. Circ. Research 67: Murphy, A.M. and R.J. Solaro. (1990) Developmental difference in the stimulation of myofibrillar Mg-ATPase activity by calmidazolium. Pediatr. Res. 28: Pan, B.S., Palmiter, K.M., Plonczynski, M. and R.J. Solaro. (1990) Slowly exchanging calcium binding sites unique to cardiac/slow muscle troponin C. J. Mol. Cell. Cardiol. 22: Solaro, R.J. (1991) Molecular aspects of cardiac muscle contraction. Proc. Conf. Adv. Sci. Tech. 7: Herzig, J.W., Rüegg, J.C. and R.J. Solaro. (1991) Myocardial excitation-contraction coupling influenced by modulation of the calcium sensitivity of the contractile protein. Heart Failure 6: Martin, A.M., Ball, K., Gao, L., Kumar, P.K. and R.J. Solaro. (1991) Identification and functional significance of troponin I isoforms in neonatal rat heart myofibrils. Circ. Res. 69:

15 Gwathmey, J.K., Hajjar, R.J. and R.J. Solaro. (1991) Contractile deactivation and uncoupling of cross-bridges: Effects of 2,3-butanedione monoxime on mammalian myocardium. Circ. Res. 69: Solaro, R.J. (1991) Regulation of Ca 2+ -signalling in cardiac myofilaments. Med. Sci. Sports and Exercise. 23: Westfall, M. and R.J. Solaro. (1992) Alterations in myofibrillar function and protein profiles following global ischemia in rat hearts. Circ. Res. 70: Westfall, M.V., Wahler, G.M., Fujino, K. and R.J. Solaro. (1992) Electrophysiological actions of the pimobendan metabolite UDCG212 CL in guinea pig myocardium. J. Pharm. Exp. Ther. 260: Solaro, R.J. (1992) Myosin and why hearts fail. Circulation 85: Paul, R.J., Heiny, J., Ferguson, D.G. and R.J. Solaro. (1993) Diversity of Muscle. In: Essentials of Basic Science: Physiology (R.O. Banks and N. Sperelakis, eds.) Little, Brown, New York, pp Rüegg, J.C. and R.J. Solaro. (1993) Calcium sensitizing positive inotropic drugs. In: Heart Failure Basic and Clinical Aspects (eds. J.K. Gwathmey, G.M. Briggs, P.D. Allen) Marcel Dekker, Inc., New York., pp Solaro, R.J. (1993) Modulation of activation of cardiac myofilaments by beta-adrenergic agonists. In: The Modulation of Cardiac Calcium Sensitivity (Allen, D.A.P. and Lee, J.L. eds.) Oxford University Press, Oxford, pp Solaro, R.J., Gao, L., Powers, F. and J.K. Gwathmey. (1993) Control of myofilament activation in heart failure. Circulation 87(VII): Westfall, M.V., Wahler, G.M. and Solaro, R.J. (1993) A highly specific benzimidazole pyridazinone reverses phosphate induced changes in cardiac myofilament activation. Biochemistry 32: Kawamura, A., Wahler, G.M. and Solaro R.J. (1993) RWJ-24517, a positive inotropic agent has novel effects on action potentials in guinea pig myocardium. J. Card. Pharmacology 22: Solaro, R.J., Gambassi, G., Warshaw, D.M., Keller, M.R., Spurgeon, H.A., Beier, N. and Lakatta, E.G. (1993) Steroselective actions of thiadiazinones on dog cardiac myocytes and myofilaments. Circ. Res. 73: Solaro, R.J., Wolska, B.M. and Westfall, M.V. (1994) Regulatory proteins and diastolic relaxation. In: Diastolic Relaxation of the Heart. (ed. by B.H. Lorell and W. Grossman) pp Ball, K.L. and Solaro, R.J. (1994) Discoordinate regulation of contractile protein gene expression in the senescent rat myocardium. J. Mol. Cell. Cardiol. 26: Averyhart-Fullard, V., Fraker, L.D., Murphy, A.M. and Solaro, R.J. (1994) Differential regulation of slow skeletal and cardiac troponin I mrna during development and by thyroid hormone treatment. J. Mol. Cell. Cardiol. 26: Guo, X., Wattanapermpool, J., Palmiter, K.A., Murphy, A.M. and Solaro, R.J. (1994) Mutagenesis of Cardiac Troponin I: Role of the Unique NH 2 -Terminal Peptide in Myofilament Activation. J. Biol. Chem. 269: Ball, K.A., Johnson, M.A., Solaro, R.J. (1994) Isoform specific interactions of troponin I and troponin C determine ph sensitivity of myofibrillar Ca 2+ -activation. Biochemistry 33:

16 Solaro, R.J. (1994) Heart failure and the response of cardiac myofilaments to Ca 2+. Heart Failure 10: Krudy, G., Kleerkoper, Q., Guo, X., Howarth, J.W., Solaro, R.J. and Rosevear, P.R. (1994) NMR studies delineating spatial relationships within the cardiac troponin I-troponin C complex. J. Biol. Chem. 269: Reiser, P.J., Westfall, M.V., Schiaffino, S. and Solaro, R.J. (1994) Tension production and thin filament protein isoforms in developing rat myocardium. Am. J. Physiol. (Cell) 267:H1589-H Solaro, R.J. (1995) Control mechanisms regulating contractile activity of cardiac myofilaments. In: Physiology and Pathophysiology of the Heart. Third Edition. (N. Sperelakis, ed.) Kluwer Academic Publishers, Boston, pp Gao, L., Kennedy, J.M. and Solaro, R.J. (1995) Differential expression of TnI and TnT isoforms in rabbit heart during the perinatal period and during cardiovascular stress. J. Mol. Cell. Cardiol. 27: Wattanapermpool, J., Reiser, P.J. and Solaro, R.J. (1995) Troponin I isoforms and differential effects of acidic ph on soleus and cardiac myofilaments. Am. J. Physiol (Cell) 268:C323-C Powers, F. and Solaro, R.J. (1995) Caffeine alters cardiac myofilament activity and regulation independent of Ca 2+ -binding to Troponin C. Am. J. Physiol. (Cell Physiol. 37) 268:C1348-C Edes, I., Kiss, E., Kitada, Y., Powers, F., Papp, J.G., Kranias, E.G. and Solaro, R.J. (1995) Effects of levosimendan, a cardiotonic agent targeted to troponin C, on cardiac function and on phophorylation and Ca 2+ -sensitivity of cardiac myofibrils and sarcoplasmic reticulum in guinea pig heart. Circ. Res. 77: Wattanapermpool, J., Guo, X. and Solaro, R.J. (1995) The unique amino-terminal peptide of cardiac troponin I regulates myofibrillar ATPase activity only when it is phosphorylated. J. Mol. Cell. Cardiol. 27: Solaro, R.J. (1995) Troponin I- Troponin C interactions and molecular signalling in cardiac myofilaments. In: Molecular and Subcellular Cardiology (S. Sideman and R. Beyar eds.) Plenum Press, New York, pp Solaro, R. John. (1995) Thin filament regulation and cardiac energetics. In: Cardiac Energetics: From EMAX to Pressure-Volume Area, (Martin M. LeWinter, Hiroyuki Suga and Matthew W. Watkins, Eds.) Kluwer Academic Publishers, pp Solaro, R.J. (1995) Molecular signalling in cardiac myofilaments. In: The Failing Heart (N.S. Dhalla, R.E. Beamish, N. Takeda, and M. Nagano, eds.) Lippincott-Raven Publishers, Philadelphia, Pennsylvania, pp Noland, T.A., Guo, X., Raynor, R.L., Averyhart-Fullard, V., Jideama, N.M., Solaro, R.J. and Kuo, J.F. (1995) Cardiac troponin I mutants: Phosphorylation by protein kinases C and A and regulation of Ca 2+ -stimulated MgATPase of reconstituted actomyosin S-1. J. Biol. Chem. 43: Kleerekoper, Q., Howarth, J.W., Guo, X., Solaro, R.J. and Rosevear, P.R. (1995) Cardiac Troponin I induced conformational changes in cardiac troponin C as monitored by NMR using site-directed spin and isotope labeling. Biochemistry 34: Rice, C.L. and Solaro, R.J. (1995) Support of the failing heart. In: Scientific American Medicine II Care in the ICU, pp Solaro, R.J. (1996) Calcium sensitizers and molecular mechanisms of altered response of cardiac myofilaments to calcium. In: Molecular and Cellular Mechanisms of Cardiovascular Regulation (M. Endoh, T. Iijima, M. Morad and H. Scholz, eds.), Springer-Verlag, Tokyo, pp

17 Wolska, B.M., Kitada, Y., Palmiter, K.A., Westfall, M.A., Johnson, M.D. and Solaro, R.J. (1996) CGP48506, a novel benzodiazocine derivative, increases contractility of ventricular myocytes and myofilaments by direct effects on the actin-myosin reaction. Am. J. Physiol. (Heart) 270:H24-H Luo, W., Wolska, B.M., Grupp, I.L., Harrer, J.M., Haghighi, K., Ferguson, D.G., Slack, J.P., Grupp, G., Doetschman, T., Solaro, R.J. and Kranias, E.G. (1996) Phospholamban gene dosage effects in the mammalian heart. Circ. Res. 78: Solaro, R.J. and Van Eyk, J. (1996) Altered interactions among thin filament proteins modulate cardiac function. J. Mol. Cell. Cardiol. 28: Response to Letter to Editor. J. Mol. Cell. Cardiol. 28: Palmiter, KA, Kitada Y, Muthuchamy M, Wieczorek DF, Solaro RJ. (1996) Exchange of - Tropomyosin for -Tropomyosin in Hearts of Transgenic Mice Induces Changes in Thin Filament Response to Ca 2+, Strong Cross-Bridge Binding, and Protein Phosphorylation. J Biol Chem 271: Wolska, B.M., Stojanovic, M.O., Luo, W., Kranias, E.G. and Solaro, R.J. (1996) Effect of ablation of phospholamban on dynamics of cardiac myocyte contraction and intracellular Ca 2+. Am. J. Physiol:Cell 271:C391-C Wolska, B.M. and Solaro, R.J. (1996) Method for isolation of adult cardiac mouse myocytes for studies of contraction and microfluorimetry. Am. J. Physiol:Heart 271:H1250-H Powers, F., Palmiter, K.A. and Solaro, R.J. (1996) E1020, a water soluble imidazopyridine, has direct effects on Ca 2+ -dependent force and ATP hydrolysis of canine and bovine cardiac myofilaments. Mol. Cell. Biochem. 160/161: Rarick, Helen M., Opgenorth, T.J., von Geldern, T.W. and Solaro, R.J. (1996) An essential myosin light chain peptide stimulates cardiac myofibrillar ATPase activity. J. Biol. Chem. 271: Noland, T.A, Raynor, R.J., Jedeama, N, Guo, X, Kazanietz, M.G., Blumberg, P.M. Solaro, R. J., Kuo, J. F. (1996) Differential Regulation of Cardiac Actomyosin S-1 MgATPase by Protein Kinase C Isozyme-Specific Phosphorylation of Specific Sites in Cardiac Troponin I and Its Phosphorylation Mutants. Biochemistry 47: Wernberg, G., Gentry, J.M., Solaro, R.J. (1996) Association of Chairmen of Departments of Physiology 1995 Survey Results. The Physiologist 39: Gentry, J.M. and Solaro, R.J. (1997) Association of Chairmen of Departments of Physiology 1995 Survey Results. The Physiologist 40: Palmiter, K.A. and Solaro, R.J. (1997) Molecular mechanisms regulating the myofilament response to Ca 2+ : Implications of mutations causal for familial hypertrophic cardiomyopathy. Basic Res. Cardiol. 92(Suppl 1) Dong, W-J., Chandra, M., Xing, J., Solaro, R.J. and Cheung, H.C. (1997) Conformation of the N-terminal segment of a monocysteine mutant of Troponin I from cardiac muscle. Biochemistry. 36: Dong, W-J., Chandra, M., Xing, J., She, M., Solaro, R.J. and Cheung, H.C. (1997) Phosphorylation-induced distance change in a cardiac muscle Troponin I mutant. Biochemistry. Biochemistry 36: Wolska, B.M., Averyhart-Fullard, V., Stojanovic, M.O., Kallen, R.G., Solaro, R.J. (1997) Changes in thyroid state affect ph i and Na i homeostasis in rat ventricular myocytes. J. Mol. Cell. Cardiol. 29: Spyracoupoulos, L., Li, M.X., Sia, S.K., Gagne, S.M., Chandra, M., Solaro, R.J., Sykes, B.D. (1997) Calcium-induced structural transition in the regulatory domain of human cardiac troponin C. Biochemistry 36: Rarick, H.M., Tu, X., Solaro, R.J., Martin, A.M. (1997) The C-terminus of cardiac troponin I is essential for full inhibitory activity and Ca 2+ -sensitivity of rat myofibrils. J Biol Chem 272:

18 Li, M.X., Gagne, S.M., Spyracoupoulos, L., Kloks, C.P.A.M., Audette, G., Chandra, M., Solaro, R.J., Smillie, L.B., Sykes, B.D. (1997) NMR Studies of Ca 2+ -binding to the Regulatory Domains of Cardiac and an E41A Skeletal Muscle Troponin C Reveal Importance of Site 1 to Energetics of the Induced Structural Changes. Biochemistry 36: Chandra M., Dong, W.-J., Pan, B.-S., Cheung, H.C., Solaro R.J. (1997) Effects of protein kinase A phosphorylation on signaling between cardiac troponin I and the N-terminal domain of cardiac troponin C. Biochemistry 36: Fraker, L., Van Eyk, J., Solaro, R.J. (1997) Reversal of phosphate induced decreases in force by the benzimidazole pyridazinone, UD-Cg 212 CL, in myofilaments from human ventricle. Molecular and Cellular Biochemistry 176: Rethinasamy, P., Muthuchamy, M., Hewett, T., Evans, C., Wolska, B.M., Solaro, R.J., Wieczorek, D.F. (1998) Molecular and physiological effects of -Tropomyosin ablation in the mouse. Circ. Res. 82: VanEyk, J.E., Powers, F.M., Law, W.R. Larue, C., Hodges, R.S., Solaro, R.J. (1998) Breakdown and Release of Myofilament Proteins during Ischemia/Reperfusion in Rat Hearts: Identification of Degradation Products and Effects on the pca-force Relation. Circ. Res. 82: Powers, F.M., Farias, S., Minami, H., Solaro, R.J., Law, W.R. (1998) Cardiac myofilament protein function is altered during sepsis. J. Mol. Cell. Cardiol. 30: Solaro, R.J., Rarick, H.M. (1998) Troponin and Tropomyosin: Proteins That Switch On and Tune In the Activity of Cardiac Myofilaments. Circ Res 83: Powers, F.M., Fogelson, Sturgeon, C., Solaro, R.J., Law, W.R. (1998) Depressed myofilament cooperativity associated with postcardioplegic myocardial depression. J. Mol. Cell. Cardiol. 30: Solaro, R.J. (1999) Invited Editorial: Troponin I, Stunning, Hypertrophy, and Failure of the Heart. Circ. Res. 84: Rarick, H.M., Tang, H-P., Guo, X-D., Martin, A.F., Solaro, R.J. (1999) Interactions at the NH 2 -terminal interface of cardiac troponin I modulate myofilament activation. J. Mol. Cell. Cardiol. 31: Piano, M.R, Rosenblum, C., Solaro, R.J., Schwertz, D. (1999) Calcium sensitivity and the effect of the calcium sensitizing drug pimobendan in the alcoholic isolated rat atrium. J. Card. Pharmacol. 33: Wolska, B.M., Keller, R.S., Evans, C.C., Palmiter, K.A., Phillips, R.M., Muthuchamy, M., Oehlenschlager, J., Wieczorek, D.F., de Tombe, P., Solaro, R.J. (1999) Correlation between myofilament response to Ca 2+ and altered dynamics of contraction and relaxation in transgenic cardiac cells that express -tropomyosin. Circ. Res. 84: Chandra, M., Montgomery, D.E., Kim, J.J., Solaro, R.J. (1999) The N-terminal region of troponin T is essential for the maximal activation of rat cardiac myofilaments. J. Mol. Cell. Cardiol. 31: Fentzke, R.C., Buck, S.H., Patel, J.R., Lin, H., Wolska, B.M., Stojanovic, M.O., Martin, A.M., Solaro, R.J., Moss, R.L., Leiden, J.M. (1999) Impaired cardiomycyte relaxation and diastolic function in transgenic mice expressing slow skeletal troponin I in the heart. J. Physiol. (London) 517: Gaponenko, V., Abusamhadneh, E., Abbott B., Finley, N., Gasmi-Seabrook, G., Solaro, R.J., Rance, M., Rosevear, P.R. (1999) Effects of TnI phosphorylation on conformational exchange in the regulatory domain of cardiac troponin C. J. Biol. Chem.(Rapid Communication) 274:

19 Schwertz, D.W., Vizgirda, V., Solaro, R.J., Piano, M.R., Ryjewski, C. (1999) Sexual dimorphism in rat left atrial function and response to adrenergic stimulation. Mol. Cell. Biochem.200: Muthuchamy, M., Pieples, K. Rethinsamy, P., Hoit, B., Grupp, I., Boivin, G., Wolska, B.M., Evans C.C., Solaro, R.J., Wieczorek, D.F. (1999) A mouse model of familial hypertrophic cardiomyopathy mutation in -tropomyosin manifest cardiac dysfunction. Circ. Res.85: Gasmi-Seabrook, G., Howarth J.W., Finley, N., Abusamhadneh, E., Gaponenko, V., Brito, R.M.M., Solaro, R.J., Rosevear, P.J. (1999) Solution structure of the C-terminal domain of cardiac troponin C complexed with the N-terminal domain of cardiac troponin I. Biochemistry 38: Finley N, Abbott MB, Abusamhadneh E, Gaponenko V, Gasmi-Seabrook G, Howarth JW, Rance M, Solaro RJ, Cheung HC, Rosevear PR. (1999) NMR anaylsis of cardaic troponin C- troponin I complexes: Effects of phosphorylation. FEBS Lett. 453: Chandra, M., Kim, J.J., Solaro, R.J. (1999) An improved method for exchanging troponin subunits in detergent skinned rat cardiac fiber bundles. Biochem. Biophys. Res. Commun.263: Solaro RJ._ Integration of myofilament response to Ca 2+ with cardiac pump regulation and pump dynamics. (1999) Adv. Physiol. Education 22: S155-S _Meehan, J., Piano, M.R., Solaro, R.J., Kennedy, J.M. (1999) Heavy long term consumption of alcohol induces an alpha-to beta-myosin heavy chain isoform transition in the rat heart. Basic. Res. Cardiovasc. 94: Dong, W-Ji, Xing, J., Villain, M., Hellinger, M., Robinson, J.M., Chandra, M., Solaro, R.J., Umeda, P.K., Cheung, H.C. (1999) Conformation of the regulatory domain of cardiac muscle troponin C in its complex with cardiac troponin I. J. Biol. Chem. 274: Solaro, R. J. (1999). Is Ca 2+ the cure for dilated cardiomyopathy? Nature Medicine 5: Solaro, RJ (2000). Mechanisms Regulating Cardiac Myofilament Response to Ca 2+. In:Heart Physiology and Pathophysiology, 4 th Edition (Sperelakis, N, Kurachi, Y, Terzik, A, and MV. Cohen, eds) pp Arteaga, GM., Palmiter KA, Leiden, JM, Solaro RJ. (2000) Attenuation of length-dependent activation in myofilaments of transgenic mouse hearts expressing slow skeletal troponin I. J Physiol (London) 526.3: Abbott MB, Dvoretsky A, Gaponenko, V, Li, G, Finley N, Rance M, Solaro, RJ, Rosevear, PJ. (2000) Regulatory domain conformational exchange and linker region flexibility in cardiac troponin C bound to cardiac troponin I. J. Biol. Chem. 275: Evans C, Pena JR, Muthuchamy M, Wieczorek DF, Solaro RJ, Wolska BM. (2000) Altered hemodynamics and response to alpha-adrenergic stimulation in transgenic mice harboring a mutant tropomyosin linked to hypertrophic cardiomyopathy. Am.J. Physiol. (Heart and Circulatory Physiology) 279:H2414-H Solaro RJ. (2000) Invited Editorial: Myosin light Chain Phosphatase: A Cinderella of Cellular Signaling. Circ Res. 87: Dong WJ, Xing J, Chandra M, Solaro RJ, Cheung HC. (2000) Structural mapping of single cysteine mutants of cardiac troponin I. Proteins 41: de Tombe PP, Solaro RJ. (2000) Integration of Cardiac Myofilament Activity and Regulation with Pathways Signaling Hypertrophy and Failure. Annals of Biomed Eng. 28: Chandra M, McManus-Rundell V, Tardiff JC, Leinwand LA, detombe PP, Solaro RJ. (2001) Ca 2+ activation of myofilaments containing a R92Q mutation in cardiac troponin T linked to hypertrophic cardiomyopathy. Am J Physiol (Heart) 280:H705-H713.

20 MacGowan GA, Du C-W, Cowan DB, Stamm C, McGowan FX, Solaro RJ, Koretsky AP, del Nido PJ (2001) Ischemic Dysfunction in transgenic mice expressing troponin I lacking protein kinase C phosphorylation sites. Am J Physiol (Heart); 280:H835-H Montgomery DE, Chandra M, Huang Q-Q, Jin J-P, Solaro RJ. (2001) Transgenic incorporation of fast skeletal troponin T into cardiac myofilaments blunts PKC-mediated depression of force. Am J Physiol (Heart) 280:H1011-H Keller RS, Shai S-Y, Babbitt C, Pham CG, Solaro RJ, Valencik ML, Loftus JC, Ross RS. (2001) Disruption of integrin signaling leads to abnormal cardiac function, fibrosis, and perinatal lethality. Am J Pathology 158: Huang L, Wolska BM, Montgomery DE, Burkart E, Buttrick PM, Solaro RJ. (2001) Increased contractility and altered Ca 2+ -transients of mouse heart myocytes conditionally expressing PKC-b Am J Physiol (Cell); 280:C1114-C Kentish JC, McCloskey DT, Layland J, Palmer S, Leiden JM, Martin AF, and Solaro RJ. (2001) Phosphorylation of troponin I by protein kinase A accelerates relaxation and crossbridge cycle kinetics in mouse ventricular muscle. Circ Res 88: Wang X, Li M, Spyracopoulos L, Beier N, Chandra M, Solaro RJ, and Sykes BD. (2001) Structure of the C-domain of human cardiac troponin C in complex with the Ca 2+ -sensitizing drug EMD J Biol Chem 276: Li G, Martin AF, Solaro RJ. (2001) Localization of regions of troponin I important in deactivation of cardiac myofilaments by acidic ph. J Mol Cell Cardiol 33: Solaro, R.J. (2001) Modulation of cardiac myofilament activity by protein phosphorylation. Handbook of Physiology: Section 2: The Cardiovascular System. Volume 1 The Heart (E. Page, H. Fozzard, R. J. Solaro, Eds.) Oxford University Press, New York, pp Wolska BM, Vijayan K, Arteaga GM, Konhilas J, Phillips RM, Kim R, Naya T, Leiden, JM,Martin AF, de Tombe PP, and Solaro RJ. (2001) Expression of slow skeletal troponin I in adult heart muscle prevents force decline during acidic conditions. J Physiol (London) 536.3: Prabhakar R, Boivin GP, Grupp IL, Hoit B, Arteaga G, Solaro RJ, Wieczorek DF. (2001) A familial hypertrophic cardiomyopathy alpha-tropomyosin mutation causes severe cardiac hypertrophy and death in mice. (2001) J Mol Cell Cardiol 33: Solaro RJ. (2001) Troponins In: Encyclopedia of Molecular Medicine (Creighton TE, ed) John Wiley and Sons, Inc., New York. pp Rice CL, Solaro RJ (2001) Support of the failing heart. In: ACS Surgery (Wilmore DW et al eds) WebMD Corp, New York, pp Montgomery DM, Wolska BM, Pyle WG, Roman BB, Dowell JC, Buttrick PM, Koretsky AP, del Nido P, Solaro RJ. (2002) Alpha-Adrenergic Response and Myofilament Activity in Mouse Hearts Lacking PKC-specific Phosphorylation Sites on Troponin I. Am J Physiol (Heart) 282:H Communal C, Sumandea M, de Tombe P, Narula J, Solaro RJ, Hajjar RJ. (2002) Functional Consequences of Caspase Activation in Cardiac Myocytes. Proc Natl Acad Sci (USA) 30:99: Solaro RJ, Wolska, BM, Arteaga G, Martin AF, Buttrick P, detombe, P. (2002) Modulation of Thin Filament Activity in Long and Short Term Regulation of Cardiac Function. In: Molecular Control Mechanisms in Striated Muscle Contraction, (RJ Solaro and RL Moss, eds), Kluwer Academic Publishers, Netherlands pp Wolska BM, Arteaga GM, Pena JM, Phillips RM, Sahai S, de Tombe PP, Martin AF, Leiden JM, Kranias EG, Solaro RJ. (2002) Expression of Slow Skeletal Troponin I in Phospholamban Knockout Mice Alters the Relaxant Effect of -Adrenergic Stimulation. Circ Res 90: PPG, Merit, RO1

21 Arteaga, GA, Kobayashi T, Solaro RJ. (2002) Molecular Actions of Drugs that Sensitize Cardiac Myofilaments to Ca 2+. Annals of Medicine 34: Solaro RJ, Varghese J, Marian AJ, Chandra M. Molecular mechanisms of cardiac myofilament activation: Modulation by ph and a troponin T mutant R92Q. (2002) Basic Res Cardiol 97:7, I102-I Martin AF, Phillips RM, Kumar A, Crawford K, Abbas Z, Lessard JL, de Tombe P and Solaro RJ. Ca 2+ -activation and Tension Cost in Myofilaments from Mouse Hearts Ectopically Expressing Enteric -actin. (2002) Am J Physiology (Heart Circ Physiol) 283:H Solaro RJ, Burkart EM. (2002) Functional defects in troponin and the systems biology of heart failure. Invited Editorial. J Mol Cell Cardiol 34: Pyle WG, Hart MC, Cooper JA, Sumandea MP, detombe PP, Solaro RJ. (2002) Actin capping protein: an essential element in protein kinase signaling to the myofilaments. Circ Res 90: Li X, Misik AJ, Rieder CV, Solaro RJ, Lowen A, Fliegel L. (2002) Thyroid hormone receptor alpha 1 regulates expression of the Na+/H+ exchanger (NHE1).J Biol Chem. ;277: Pyle WG, Sumandea MP, Solaro RJ, detombe PP. (2002) Troponin I serines 43/45 and regulation of cardiac myofilament function. Am J Physiol (Heart Circ Physiol) 283:H Pieples K, Arteaga G, Solaro RJ, Grupp I, Lorena JN, Boivin GP, Ganapathy J, Labitzke E, detombe PP, Konhilas JP, Irving TC, Wieczorek DF. (2002) Expression of tropomyosin 3 in murine hearts leads to hyper-contractility and attenuates myofilament length dependent Ca 2+ activation. Am J Physiol (Heart Circ Physiol) 283:H1344- H Solaro RJ, Montgomery DE, Wang Lynn, Burkart EM, Ke Y, Vahebi S, Buttrick P. (2002) Integration of pathways that signal cardiac growth with modulation of myofilament activity. J Nuc Cardiol 9: Konhilas JP, Irving TC, Wolska BM, Martin AF, Jweid E, Solaro RJ, detombe PP. (2003) Troponin I in the heart: Influence on length-dependent activation and interfilament spacing. J Physiol (London) 547.3: Burkart EM, Sumandea, MP, Kobayashi T, Nili M, Homsher E, Solaro RJ. (2003)Phosphorylation or glutamic acid substitution at protein kinase C sites on cardiac troponin I differentially depress myofilament tension and shortening velocity. J Biol Chem 278: Jagatheesan G, Rajan S, Petrashevskaya N, Schwartz A, Boivin G, Vahebi S, Solaro RJ, detombe PP, Labitzke E, Hilliard G, Wieczorek DF.(2003) Functional importance of the C-terminal region of striated muscle tropomyosin. J Biol Chem 278: Sumandea MP, Pyle WG, Kobayashi T, de Tombe PP, Solaro RJ. (2003) Identification of a functionally critical PKC phosphorylation residue of cardiac troponin. J Biol Chem 278: Burkart EM, Arteaga GM, Sumandea, MP, Prabhakar R, Wieczorek DF, Solaro RJ. (2003) Altered Signaling Surrounding The C-Lobe of Cardiac Troponin C in Myofilaments Containing an -Tropomyosin Mutation Linked to Familial Hypertrophic Cardiomyopathy. J Mol Cell Cardiol 35:

22 Ke Y, Wang L, Pyle WG, de Tombe PP, and Solaro RJ. (2004) Intracellular Localization and Functional Effects of P 21 activated kinase-1 (Pak1) in Cardiac Myocytes. Circ Res 94: Opie LH, Solaro RJ. Chapter 8. Myocardial Contraction and Relaxation. In: Heart Physiology, From Cell to Circulation, 4 th Edition (LH Opie Ed). Lippincott, Williams, and Wilkins, Philadelphia pp , Pyle WG, Solaro RJ. At the crossroads of myocardial signaling: The Role of Z-discs in Intracellular Signaling and Cardiac Function. (2004) Circ Res 94: Sumandea MP, Burkart EM, Kobayashi T, de Tombe PP, Solaro RJ. (2004) Molecular and Integrated Biology of Thin Filament Protein Phosphorylation in Heart Muscle. Ann NY Acad Sci 1015: Yang X, Wu H, Kobayashi T, Solaro RJ, van Breemen RB. (2004) Enhanced Ionization of Phosphorylated Peptides During MALDI-TOF Mass Spectrometry. Analytical Chemistry 76: Solaro RJ. The special structure and function of troponin I in regulation of cardiac contraction and relaxation. (2004) Adv Exp Biol Med 2004; 538: Roman BB, Goldspink PH, Spaite E, Urboniene D, McKinney R, Geenen DL, Solaro RJ, Buttrick PM. (2004) Inhibition of PKC phosphorylation of ctni improves cardiac performance in vivo. Am J Physiol Heart Circ Physiol. 286:H Layland J, Grieve DJ, Cave AC, Sparks E, SolaroRJ, Shah AM. Essential role of troponin I in the positive inotropic response to isoprenaline in mouse hearts contracting auxotonically. J Physiol (London). 2004; 556.3: Kobayashi T, Dong W-J, Burkart EM, Cheung HC, and Solaro RJ. (2004) Effects of protein kinase C dependent phosphorylation and a familial hypertrophic cardiomyopathy-related mutation of cardiac troponin I on structural transition of troponin C and myofilament activation. Biochemistry; 43: Jagatheesan G, Rajan S, Petrashevskaya N, Schwartz A, Boivin A, Arteaga G, De Tombe PP, SolaroRJ, Wieczorek DF. (2004) Physiological significance of troponin T binding domains in striated muscle tropomyosin. Am J Physiol (Heart) ;287:H Goldspink PH, Montgomery DE, Walker LA, Urboniene D, McKinney RD, Geenen DL, Solaro RJ, Buttrick PM. (2004) Protein Kinase C{epsilon} Overexpression Alters Myofilament Properties and Composition During the Progression of Heart Failure.Circ Res 95: Towbin JA, Solaro RJ. (2004) Genetics of dilated cardiomyopathy: More genes that kill. J Am Coll Cardiol 44: Gomes AV, Venkatraman GV, Davis J, Tikunova S, Engel P, Solaro RJ, Potter JD. (2004) Cardiac troponin T isoforms affect the Ca 2+ sensitivity of force development in the presence of slow skeletal troponin I: Insights into the role of troponin T isoforms in the fetal heart. J Biol Chem. Nov 26;279(48): Epub 2004 Nov Sorsa T, Pollesello P, Solaro RJ. (2004) The contractile apparatus as a target for drugs against heart failure: interaction of levosimendan, a calcium sensitizer, with cardiac troponin C. Mol Cell Biochem.266: Kobayashi T, Yang X, Walker LA, Van Breemen RB, Solaro RJ. A non-equilibrium isoelectric focusing method to determine states of phosphorylation of cardiac troponin I: Identification of Ser-23 and Ser-24 as significant sites of phosphorylation by protein kinase C. J Mol Cell Cardiol Jan;38(1): Epub 2004 Dec Solaro RJ, Westfall MV. (2005) Physiology of the Myocardium. In:Surgery of the Chest (Sellke FW, del Nido PJ, Swanson SJ eds) Elsevier Sanders (Philadelphia, PA) pp Parmacek MS, Solaro RJ. (2005) Biology of the Troponin Complex in Cardiac Myocytes. Prog. Card. Dis. 47:

23 Kobayashi T, Solaro RJ. Calcium, (2005) Thin Filaments, and Integrative Biology of Cardiac Contractility. Annu Rev Physiol. 67: [Jul 21, 2004; Epub ahead of print] 227. Layland J, Solaro RJ, Shah AM. (2005) Regulation of cardiac contractile function by troponin I phosphorylation. Cardiovasc Res. 66: Layland J, Cave AC, Grieve DJ, Sparks E, Kentish JC, Warren C, Solaro RJ, Shah AM. (2005) Protection against endotoxaemia induced contractile dysfunction in mice with cardiac-specific expression of slow skeletal troponin I. FASEB J. 19: (EPub Apr 26, 2005) Vahebi S, Kobayashi T, Warren CM, de Tombe PP, R. Solaro RJ. (2005) Functional Effects of Rho-kinase (ROCK-II) Dependent Phosphorylation of Specific Sites on Cardiac Troponin. Circ Res. 96: Urboniene D, Dias F, Peña JR, Walker LA, Solaro RJ, Wolska BM. Expression of Slow Skeletal Troponin I in Adult Mouse Heart Helps to Maintain the Left Ventricular Systolic Function During Respiratory Hypercapnia. Circ Res. 2005;97: Solaro RJ, Hasenfuss G. (2005) Control of cardiac function in health and disease by mechanisms at the level of the sarcomere. In: Molecular Mechanism of Cardiac Hypertrophy and Failure (Walsh RA, ed) Taylor and Francis Group (London) pp Arteaga GM,, Warren CM, Milutinovic S, Martin AF, Solaro RJ. (2005) Specific Enhancement of Sarcomeric Response to Ca2+ Protects Murine Myocardium Against Ischemia/Reperfusion Dysfunction. Am J Physiol Heart Circ Physiol. 2005; 289:H Jul 15; [Epub ahead of print] PMID: Vahebi S, Solaro RJ. (2005) Cardiac Sarcomeric Function, Small G-protein Signaling, and Heart Failure. Panminerva Medica 47: PMID: Solaro RJ. Remote control of A-band cardiac thin filament by the I-Z-I network of cardiac sarcomeres. (2005) Trends in Cardiovasc Med. 15: Kass D, Solaro RJ. (2006) Mechanisms and Use of Calcium Sensitizing Agents. Circulation. 113: PMID: Scruggs SB, Walker LA, Lyu T, Geenen DL, Solaro RJ, Buttrick PM, Goldspink PH. (2006) Partial Replacement of Cardiac Troponin I with a Non-Phosphorylatable Mutant at Serines 43/45 Attenuates the Contractile Dysfunction Associated with PKC epsilon Phosphorylation. J Mol Cell Cardiol. 40: Kobayashi T, Solaro RJ. Increased Ca 2+ -affinity of cardiac thin filaments reconstituted with cardiomyopathy related mutant troponin I. J Biol Chem 2006;281: Epub 2006 Mar Biesiadecki BJ, Solaro RJ. Invited Editorial. When hearts fail so does skeletal muscle: breaking a vicious cycle. Circ Res 2006; 98: PMID: McCall SJ, Nassar R, Malouf NN, Saunders AJ, Oakeley AE, Henderson PM, Solaro RJ, Pielak GJ, Alexander KA, Anderson PAW. Development and contractility: cardiac troponin T isoforms and cytosolic calcium. Pediatric Res 2006; 60: PMID: Pyle WG, de Tombe PP, Sumandea MP, Solaro RJ. Control of cardiac myofilaemt activation and PKC-β II signaling through the actin capping protein, CapZ. J Mol Cell Cardiol 2006; 41: PMID: Belin RJ, Sumandea MP, Kobayashi T, Walker LA, Rundell VL, Yukahakova M, Ruch SH, Geenen DL, Solaro RJ, de Tombe PP. Molecular mechanism of depressed left ventricular myofilament function in experimental left ventricular hypertrophy and

24 24 congestive heart failure. Am J Physiol Heart Circ Physiol. 2006; 291:H Epub 2006 Jun 30.) PMID: Solaro RJ, Arteaga GM. (2007) Heart failure, ischemia/reperfusion injury and cardiac troponin. In: Regulatory mechanisms of Striated Muscle Contraction (Ebashi S, Ohtsuki I, eds.) Adv Exp Med Biology 592: Springer (Tokyo) PMID: Bupha-Intr T, Wattanapermpool J, Pena JR, Wolska BM, Solaro RJ. (2007) Myofilament response to Ca 2+ and Na + /H + exchanger activity in sex hormone elated protection of cardiac myocytes from deactivation in hypercapnic acidosis. Am J Physiol (Reg Integ). 292 :R Epub 2006 Oct 12. PMID: Engel PL, Kobayashi T, Biesiadecki B, Davis J, Tikunova S, Wu S, Solaro RJ. (2007) Identification of a region of troponin I important in signaling cross-bridge dependent activation of cardiac myofilaments. J Biol Chem. 282: Epub 2006 Nov 12. PMID: Vahebi S, Ota A, Li M, Warren CM, de Tombe PP, Want Y, Solaro RJ. (2007) p38- MAPK Induced Dephosphorylation of Alpha-Tropomyosin is Associated with Depression of Myocardial Sarcomeric Tension and ATPase Activity. Circ Res 100: PMID: Solaro RJ. (2007) Nitroxyl (HNO) Effects on Myocardium Provides New Insights into the Significance of Altered Myofilament Response to Calcium in Regulation of Contractility. J Physiol. 580: 697. PMID: Hinken A, Solaro RJ. (2007) A Dominant Role of Intrinsic Regulation of Cardiac Molecular Motors in the Control of Ventricular Ejection and Relaxation. Physiology 22: PMID: Davis JP, Alionte C, Kobayashi T, Solaro RJ, Swartz DR, Tikunova SB. (2007) Effects of thin and thick filament proteins on calcium binding and exchange with cardiac troponin C. Biophysical J 92: PMID: Ke Y, Lum H, Solaro, RJ. (2007) Dephosphorylation of Myosin regulatory Light Chain and Inhibition of Barrier Dysfunction Induced by P 21 Activated Kinase-1 in Endothelial Cells. Canadian J Physiol and Pharm ;85: PMID: (HL 64035; T32 HL 07692) 250. Ke Y, Lei M, Collins TP, Rakovic S, Mattick PAD, Yamasaki M, Brodie MS, Terrar DA, Solaro RJ. (2007) Regulation of L-type calcium channel and delayed rectifier potassium channel activity by P 21 activated kinase-1 in guinea-pig sino-atrial node pacemaker cells. Circ Res. 100: PMID: (HL22231 and 64035) 251. Jagatheesan G, Rajan S, Petrashevskaya N, Schwartz A, Boivin G, Arteaga GM, Solaro RJ, Liggett SB, Wieczorek DF. (2007) Rescue of tropomyosin-induced familial hypertrophic cardiomyopathy mice by transgenesis. Am J Physiol Heart Circ Physiol. 293: H949-H958. PMID: Biesiadecki BJ, Kobayashi T, Walker JS, Solaro RJ, de Tombe PP. Troponin C G159D Mutation Blunts Myofilament Desensitization induced by Troponin I PKA Phosphorylation. Circ Res 2007; 100: Apr 19; [Epub ahead of print] PMID: Xiao L, Zhao Q, Du Y, Chao Y, Solaro RJ, Buttrick PM. (2007) PKC increases phosphorylation of the cardiac myosin binding protein C at Serine 302 both in vitro and in vivo. Biochemistry 2007; 46: May 16; [Epub ahead of print] PMID: ( PO1 HL 62426) Rajan S, Ahmed RPH, Jagatheesan G, Petrashevskaya N, Boivin GP, Urboniene D, Arteaga GM, Wolska BM, Solaro RJ, Liggett SB, Wieczorek DF. Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with

25 25 significantly deceased fractional shortening and myofilaments calcium sensitivity. Circ Res 2007;101: June 7 [Epub ahead of print] PMID: (HL and PO1 HL 62426) Belin RJ, Sumandea MP, Allen EA, Schoenfelt K, Wang H, Solaro RJ, de Tombe PP. Augmented protein kinase C-alpha induced myofilament protein phosphorylation contributes to myofilaments dysfunction in experimental congestive heart failure. Circ Res 2007; 101: June [Epub ahead of print]. PMID: ( PO1 HL and HL 64035) Solaro RJ. Translational medicine with a capital T, troponin T, that is. Circ Res. 2007; 101: PMID: NIH PO1, RO1s 257. Sheehan KA, Ke Y, Solaro RJ. P 21 Activated kinase-1 and its role in integrated regulation of cardiac contractility. Am J Physiol. Am J Physiol Regul Integr Comp Physiol :R PMID: Lei M, Ke Y, Solaro RJ. Pak1: steps towards understanding the regulatory mechanisms of pacemaker function of the heart. Future Medicine (Invited Editorial). 2007;3 (In Press) Howarth JW, Meller J, Solaro RJ, Trewhella J, Rosevear PR. Phosphorylation - dependent conformational transition of the cardiac specific n-extension of troponin I in cardiac troponin. J Mol Biol. 2007; 373: PMID: Wu SC, Solaro RJ. (2007)Protein Kinase C Zeta: A Novel Regulator Controlling Both Phosphorylation and De-Phosphorylation of Cardiac Sarcomeric Proteins. J Biol Chem 2007; 282: Aug 27; [Epub ahead of print].pmid: Solaro RJ. New and Notable: Mechanisms of the Frank-Starling Law of the Heart: The beat goes on. Biophys J. 2007; 93: Epub 2007 Aug 31.Aug 31; [Epub ahead of print]. PMID: Warren CM, Arteaga GM, Rajan S, Ahmed RPH, Wieczorek DF, Solaro RJ. (2008) Use of 2D-DIGE analysis reveals altered phosphorylation in tropomyosin mutant (Glu54Lys) linked to dilated cardiomyopathy. Proteomics. 8: PMID: Solaro RJ, Rosevear, Kobayashi T. (2008) The unique functions of cardiac troponin I in the control of cardiac muscle contraction and relaxation. Biochem Biophys Res Commun. 369: Dec 24; [Epub ahead of print] PMID: Solaro RJ, detombe PP. (2008) Review focus series: sarcomeric proteins as key elements in integrated control of cardiac function. Cardiovasc Res Mar 1;77(4): Epub 2008 Jan 10. PMID: doi: /cvr/cvn Minami H, Wolska BM, Stojanovic MO, Solaro RJ. (2008) Reversal of effects of acidosis on contraction of rat heart myocytes by CGP Frontiers in Biosciences. 13: PMID: Ke Y, Solaro RJ. Use of a decoy peptide to purify p21 activated kinase-1 in cardiac muscle and identification of ceramide-related activation. Biologics Dec;2(4): PubMed PMID: ; PubMed Central PMCID: PMC Nowak G, Pena JR, Urboniene D, Geenen DL, Solaro RJ, Wolska BM. (2008) Correlations Between Alterations in Length-Dependent Ca 2+ Activation of Cardiac Myofilaments and the End-Systolic Pressure-Volume Relation. J Mus Res Cell Motility 28: Epub 2008 Mar 26. PMID: Tachampa K, Kobayashi T, Wang H, Martin A, Biesiadecki B, Solaro RJ, de Tombe PP. (2008) Increased crossbridge cycling kinetics after exchange of C-terminal

26 26 truncated troponin-i in skinned rat cardiac muscle. J Biol Chem 283: Epub 2008 Mar 31.PMID: Yuan C, Solaro RJ. (2008) Myofilament proteins: From cardiac disorders to proteomic changes. Proteomics Clin Appl 2: Yuan C, Sheng Q, Tang H, Li Y, Zeng R, Solaro RJ. Quantitative Comparison of Sarcomeric Phospho-Proteomes of Neonatal and Adult Rat Hearts. Am J Physiol Heart Circ Physiol Aug;295(2):H Epub 2008 Jun 13. PMID: Sumandea MP, Rybin VO, Hinken AC, Wang C, Kobayashi T, Harleton E, Sievert G, Balke CW, Feinmark SJ, Solaro RJ, Steinberg SF. Tyrosine phosphorylation modifies PKCdelta -dependent phosphorylation of cardiac troponin I. J Biol Chem Jun 12. [Epub ahead of print] PMID: Solaro RJ. (2008) Multiplex Kinase Signaling Modifies Cardiac Function at the level of Sarcomeric proteins. J Biol Chem Oct 3;283(40): Epub 2008 Jun Rudy Y, Ackerman MJ, Bers DM, Clancy C, Houser SR, London B, McCulloch A, Przywara DA, Rasmusson R, Solaro RJ, Trayanova NA, Van Wagoner D, Varró A, Weiss JN, Lathrop DA. (2008) Systems Approach to Understanding Electromechanical activity in the human heart: A National Heart, Lung, and Blood Institute Workshop Summary. Circulation 118: PMID: PPG, Merit, RO Sheehan KA, Ke Y, Wolska BM, Solaro RJ. Expression of Active p21-activated Kinase-1 (Pak1) Induces Ca2+-flux Modification with Altered Regulatory Protein Phosphorylation in Cardiac Myocytes. Am J Physiol Cell Physiol. 2009; 296:C47-C58. Oct 15. [Epub ahead of print] PMID: 275. Baudenbacher F, Schober T, Pinto JR, Sidorov VY, Hilliard F, Solaro RJ, Potter JD, Knollmann BC. (2008) Myofilament calcium sensitization causes susceptibility to cardiac arrhythmia. J Clin Invest. 2008; Nov 20. [Epub ahead of print] PMID: Solaro RJ. (2009) Maintaining cooperation among cardiac myofilament proteins through thick and thin. J. Physiol (London) 587.1: 3. PMID: Scruggs SB, Hinken AC, Thawornkaiwong A, Robbins J, Walker LA, de Tombe PP, Geenen DL, Buttrick PM, Solaro RJ. (2009) Ablation of ventricular myosin regulatory light chain phosphorylation in mice causes cardiac dysfunction in situ and affects neighboring myofilament protein phosphorylation. J Biol Chem. 284: Dec 23. [Epub ahead of print] PMID: PPG, 278. Abraham SJ, Kobayashi T, Solaro RJ, Gaponenko V. (2009) Differences in lysine pka values may be used to improve NMR signal dispersion in reductively methylated proteins. J Biomol NMR Apr;43(4): Epub 2009 Mar Hartman TJ, Martin JL, Solaro RJ, Samarel AM, Russell B. CapZ dynamics are altered by endothelin-1 and phenylephrine via PIP2 and PKC-dependent mechanisms. Am J Physiol Cell Physiol Mar 18. [Epub ahead of print] PMID: Warren CM, Kobayashi T, Solaro RJ. (2009) Sites of Intra and Inter-Molecular Cross- Linking of the N-Terminal Extension of Troponin I in Human Cardiac Whole Troponin Complex. J Biol Chem. 2009; 284: Mar 24. [Epub ahead of print] PMID: Solaro RJ. (2009) CK , a sarcomere-directed cardiac myosin activator for acute and chronic heart disease. IDrugs 12: Apr;12(4): PubMed PMID: Ke Y, Lei M, Solaro RJ. Regulation of cardiac excitation and contraction by p21 activated kinase-1. Prog Biophys Mol Biol Oct-Nov;98(2-3): PubMed PMID: ; PubMed Central PMCID: PMC Engel PL, Hinken A, Solaro RJ. Differential effects of phosphorylation of regions of

27 27 troponin I in modifying cooperative activation of cardiac thin filaments. J Mol Cell Cardiol Sep;47(3): Epub 2009 May 5. PubMed PMID: ; PubMed Central PMCID: PMC Jagatheesan G, Rajan S, Schulz EM, Ahmed RP, Petrashevskaya N, Schwartz A, Boivin GP, Arteaga GM, Wang T, Wang YG, Ashraf M, Liggett SB, Lorenz J, Solaro RJ, Wieczorek DF. An internal domain of beta-tropomyosin increases myofilament Ca(2+) sensitivity. Am J Physiol Heart Circ Physiol Jul;297(1):H Epub 2009 May 8. PubMed PMID: ; PubMed Central PMCID: PMC Kirk JA, MacGowan GA, Evans C, Smith SH, Warren CM, Mamidi R, Chandra M, Stewart AF, Solaro RJ, Shroff SG. Left ventricular and myocardial function in mice expressing constitutively pseudophosphorylated cardiac troponin I. Circ Res Dec 4;105(12): Epub 2009 Oct 22. PubMed PMID: PMCID: PMC Egom EE, Ke Y, Musa H, Mohamed TM, Wang T, Cartwright E, Solaro RJ, Lei M. FTY720 prevents ischemia/reperfusion injury-associated arrhythmias in an ex vivo rat heart model via activation of Pak1/Akt signaling. J Mol Cell Cardiol Feb;48(2): Epub 2009 Oct 21. PubMed PMID: NIHMS PPG MPI 287. Rajan S, Jagatheesan G, Karam CN, Alves ML, Bodi I, Schwartz A, Bulcao CF, D'Souza KM, Akhter SA, Boivin GP, Dube DK, Petrashevskaya N, Herr AB, Hullin R, Liggett SB, Wolska BM, Solaro RJ, Wieczorek DF. Molecular and functional characterization of a novel cardiac-specific human tropomyosin isoform. Circulation Jan 26;121(3): Epub 2010 Jan 11. PubMed PMID: ; PubMed Central PMCID: PMC MERIT and PPG 288. Egom EE, Ke Y, Solaro RJ, Lei M. Cardioprotection in ischemia/reperfusion injury: Spotlight on sphingosine-1-phosphate and bradykinin signalling. Prog Biophys Mol Biol Sep;103(1): Epub 2010 Jan 18. PubMed PMID: : 289. Lee DI, Vahebi S, Tocchetti CG, Barouch LA, Solaro RJ, Takimoto E, Kass DA.PDE5A suppression of acute beta-adrenergic activation requires modulation of myocyte beta-3 signaling coupled to PKG-mediated troponin I phosphorylation.basic Res Cardiol May;105(3): Epub 2010 Jan 27.PMID: PMCID: PMC PPG, MERIT 290. Solaro RJ. Guest editor's introduction. The activity of cardiac myocytes reflects a confluence of a multitude of electrical and chemical signals that promote and control the ability of the myocytes to shorten and develop force. J Mol Cell Cardiol. 2010; 48:809 Feb 10. [Epub ahead of print] PubMed PMID: Ke Y, Sheehan KA, Egom EE, Lei M, Solaro RJ. Novel bradykinin signaling in adult rat cardiac myocytes through activation of p21 activated kinase. Am J Physiol Heart Circ Physiol Apr;298(4):H Epub 2010 Feb 12. PMID: PMCID: PMC MERIT MPI 292. Lu QW, Hinken AC, Patrick SE, Solaro RJ, Kobayashi T. Phosphorylation of cardiac troponin I at protein kinase C site threonine-144 depresses cooperative activation of thin filaments. J Biol Chem Apr 16;285(16): Epub 2010 Feb 17.PMID: PMCID: PMC MERIT, PPG 293. Solaro RJ, van der Velden J.(2010) Why does troponin I have so many phosphorylation sites? Fact and Fancy. J Mol Cell Cardiol. 2010; 48: Feb 25. [Epub ahead of print] PMID: PMCID: PMC

28 Warren CM, Geenen DL, Helseth DL, Xu H, Solaro RJ. Sub-Proteomic fractionation, itraq, and OFFGEL-LC-MS/MS approaches to cardiac proteomics. J Proteomics Jun 16;73(8): Epub 2010 Apr 12. PMID: PMCID: PMC MERIT, PPG 295. Biesiadecki. BK. Tachampa K, Yuan C, Jin J-P, de Tombe PP, Solaro RJ. (2010) Removal of the N-terminal extension of cardiac troponin I improves cardiac function during aging. J Biol Chem Jun 18;285(25): Epub 2010 Apr 21.PMID: PMCID: PMC PPG MERIT 296. Scruggs SC, Reisdorph R, Armstrong ML, Warren CM, Reisdorph N, Solaro RJ, Buttrick PM. (2010) A novel, in solution separation of endogenous cardiac sarcomeric proteins and identification of distinct charged variants of regulatory light chain. Mol Cell Prot 2010 Sep;9(9): Epub 2010 May 5.PMID: PMCID: PMC Solaro RJ, (2010) J Biomed Biotech. Special Issue on Muscle Physiology and Pathophysiology: Sarcomere Control Mechanisms and the Dynamics of the Cardiac Cycle. 2010;2010: Epub 2010 May 10.PMID: PMCID: PMC Solaro RJ, Warren CM, Scruggs SB. (2010) Why is it important to analyze the caraic sarcomere subproteome? Expert Rev Proteomics Jun;7(3): PMID: Avner BS, Hinken AC, Yuan C, Solaro RJ. (2010) Hydrogen peroxide alters rat cardiac sarcomere function and protein phosphorylation through redox signaling. Am J Physiol Heart Circ Physiol 2010 Sep;299(3):H Epub 2010 Jun PMID: PMCID: PMC MERIT, PPG 300. Solaro RJ, detombe PP. Reply to Smith Letter. Controversy persists after over 100 years of the Frank-Starling mechanism. J Mol Cell Cardiol 2010 PMCID: PMC Solaro RJ, Sheehan KA, Lei M, Ke Y. (2010) The curious role of sarcomeric proteins in control of diverse processes in cardiac myocytes. J Gen Physiol 136:3-9. PMID: PMCID: PMC Jagatheesan G, Rajan S, Ahmed RP, Petrashevskaya N, Boivin G, Arteaga GM, Tae HJ, Liggett SB, Solaro RJ, Wieczorek DF. Striated muscle tropomyosin isoforms differentially regulate cardiac performance and myofilament calcium sensitivity. J Muscle Res Cell Motil. J Muscle Res Cell Motil Sep;31(3): Epub 2010 Aug 28. PMID: PMCID: PMC Force T, Bonow RO, Houser SR, Solaro RJ, Hershberger RE, Adhikari B, Anderson ME, Boineau R, Byrne BJ, Cappola TP, Kalluri R, LeWinter MM, Maron MS, Molkentin JD, Ommen SR, Regnier M, Tang WH, Tian R, Konstam MA, Maron BJ, Seidman CE. Research priorities in hypertrophic cardiomyopathy: report of a Working Group of the National Heart, Lung, and Blood Institute. Circulation Sep 14;122(11): PMID: Peña JR, Szkudlarek, AC, Warren CM, Gaffin RD, Heinrich LS, Jagathessen G, del Monte F, Hajjar RJ, Goldspink PH, Solaro RJ, Wieczorek DF, Wolska BM. (2010) Neonatal Gene Transfer of Serca2a Delays Onset of Hypertrophic Remodeling and Improves Function in Familial Hypertrophic Cardiomyopathy. J Mol Cell Cardiol Dec;49(6): Epub 2010 Sep 18.PMID: PMCID: PMC All Grants 305. Sheehan KA, Arteaga GM, Hinken AC, Dias FA, Ribeiro C, Wieczorek DF, Solaro RJ, Wolska BM. Functional effects of a tropomyosin mutation linked to FHC contrtibute to maladaptation during acidosis. J Mol Cell Cardiol Mar;50(3): Epub 2010 Nov 1 PMID: PMCID: PMC MERIT, MPI 306. Shioura K, Farjah M, Geenen D, Solaro RJ, and Paul Goldspink P. Myofilament

29 29 calcium sensitization delays decompensated hypertrophy differently between the sexes following myocardial infarction. Am J Physiol Regul Integr Comp Physiol Feb;300(2):R Epub 2010 Nov PMID: PMCID: PMC PPG 307. Karam CN, Warren CM, de Tombe PP, Rajan S, Wieczorek DF, Solaro RJ. Expression of a novel tropomyosin isoform, tropomyosin-kappa, induces dilated cardiomyopathy and depresses cardiac myofilament tension by mechanisms involving cross bridge dependent activation and altered tropomyosin phosphorylation. J Muscle Res Cell Motil Mar;31 (5-6): Epub 2011 Jan 9. PMID: NIHMS Solaro RJ, Stull JT Thematic minireview series: Signaling in cardiac sarcomeres in health and disease. J Biol Chem Mar 25;286(12):9895. Epub 2011 Jan 21 PMID: PMCID: PMC Solaro RJ, Kobayashi T. Protein phosphorylation and signal transduction in cardiac thin filaments. J Biol Chem Mar 25;286(12): Epub 2011 Jan 21. PMID: PMCID: PMC Scruggs SC, Solaro RJ. The significance of regulatory light chain phosphorylation in cardiac physiology. Arch Biochem Biophys Jun 15;510(2): Epub 2011 Feb 21.PMID: PMCID: PMC All grants Solaro RJ. Regulation of Cardiac Contractility (J. Granger and N. Granger eds) Morgan & San Rafael (CA): Morgan & Claypool Life Sciences; 2011.PMID: Pound KM, Arteaga GM, Fasano M, Wilder T, Fischer SK, Warren CM, Wende AR, Farjah M, Abel AD, Solaro RJ, Lewandowski ED. Expression of slow skeletal TnI in adult mouse hearts convers metabolic protection to ischemia. J Mol Cell Cardiol 2011 Aug;51(2): Epub 2011 May 26.PMID: PMCID: PMC PPG, Merit 313. Egom EEA, Mohamed TMA, Mamas MA Shi Y, Liu W, Chirico D, Stringer SE, Ke Y, Shaheen M, Wang T, Chacko S, Wang X, Solaro RJ, Fath-Ordoubadi F, Cartwright EJ, Lei M. Activation of Pak1/Akt/eNOS signaling following sphingosine-1-release as part of a mechanism protecting cardiomyocytes against ischemic cell injury. Am J Physiol Heart Circ Physiol2011 Oct;301(4):H Epub 2011 Jun 24.PMID: Ai X, Jiang A, Ke Y, Solaro RJ, Pogwizd SM. Enhanced activation of p21-activated kinase 1 in heart failure contributes to dephosphorylation of connexin 43. Cardiovascular Research 2011 Oct 1;92(1): Epub 2011 Jul 3.. [Epub ahead of print] PMID: Belin RJ, Sumandea MP, Sievert GA, Harvey LA, Geenen DL, Solaro RJ, de Tombe PP. Interventricular differences in myofilament function in experimental congestive heart failure. Pflugers Arch Dec;462(6): Epub 2011 Sep 17. PMID: PMCID:PMC Taglieri DM, Monasky MM, Knezevic I, Sheehan KA, Lei M, Wang X, Chernoff J, Wolska BM, Ke Y, Solaro RJ. Ablation of p21-activated kinase-1 promotes isoproterenolinduced hypertrophy in associate with activation of ERK ½ and inhibition of protein phosphatase 2A. J Mol Cell Cardiol. 2011; 51: Sep 24. [Epub ahead of print] PMID: PMCID: PMC Liu W, Zi M, Naumann R, Ulm S, Jin J, Taglieri DM, Prehar S, Gui J, Tsui H, Xiao RP, Neyses L, Solaro RJ, Ke Y, Cartwright EJ, Lei M, Wang X. Pak1 as a Novel Therapeutic Target for Anti-Hypertrophic Treatment in the Heart. Circulation. 2011;124: Nov 14. [Epub ahead of print] PMID: PMCID:PMC

30 Avner BS, Shioura KM, Scruggs SB, Grachoff M, Geenen DL, Helseth, Jr. DL, Farjah M, Gopldspink PH, Solaro RJ. Myocardial Infarction in Mice Alters Sarcomeric Function Via Post-Translational Protein Modification. Mol Cell Biochem 2012 Apr;363 (1-2): doi: /s z. Epub 2011 Dec 8.PMID: Monasky MM, Taglieri DM, Patel BG, Chernoff J, Wolska BM, Ke Y, Solaro RJ. P21- activated kinase improves cardiac contractility during Ischemia-reperfusion concomitant with changes in Troponin-T and Myosin Light Chain 2 Phosphorylation. Am J Physiol Heart Circ Physiol. 2012; 302: H Oct 28. [Epub ahead of print] PMID: PMCID:PMC Solaro RJ, Leinwand L. Role of Sarcomeres in Cellular Tension, Shortening and Muscle: Fundamental Biology and Mechanisms of Disease; Vol 1, Chapter 13 (J. A. Hill, E. N. Olson, eds) Elsevier, Amsterdam 2012; pp Knezevic I, Patel A, Sundaresan NR, Gupta MP, Solaro RJ, Sundaresan RN, Gupta M. A novel cardiomyocyte enriched microrna, mir-378, targets IGF1R: implications in post natal cardiac remodeling and cell survival. J Biol Chem Apr 13;287(16): Epub 2012 Feb 24 PMID: PMCID: PMC [Available on 2013/4/13] 322. Lovelock JD, Monasky MM, Jeong E-M, Lardin HA, Liu H, Patel BG, Taglieri DM, Gu L, Kumar P, Pokhrel N, Zeng D, Belardinelli L, Sorescu D, Solaro RJ, Dudley Jr. SC. Ranolazine improves cardiac diastolic dysfunction through modulation of myofilament calcium sensitivity. Circ Res : Feb 16. [Epub ahead of print] PMID: PMIC: NIHMSID# PMID: PMIC: Nixon BR, Thawornkaiwong A, Jin J, Brundage EA, Little SC, Davis JP, Solaro RJ, Biesiadecki BJ. AMP-activated kinaseamp activated protein kinase phosphorylates cardiac troponin I at Ser-150 to increase myofilament calcium sensitivity and blunt PKA dependent function. J Biol Chem Jun 1: 287 (23) : Epub 2012 Apr Apr 6. [Epub ahead of print] PMID: PMID: PMCID:PMC Hinken AC Hanft LM, Scruggs SB, Sadayappan S, Robbins J, Solaro RJ, McDonald KS. Protein kinase C depresses cardiac myocyte power output and attenuates myofilament responses induced by protein kinase A. J Muscle Res Cell Motility2012 Apr 22. [Epub ahead of print] PMID: PMCID: PMC Solaro RJ, Rao MC. Kate Bárány: A life of science, teaching, and service. J Muscle Res Cell Motility 2012 May 22. [Epub ahead of print] PMID: Lai H-L, Grachoff M, Marion AL, Khan FF, Warren CM, Chowdhury SAK, Wolska BM, Solaro RJ, Geenen DL, Wang QT. Maintenance of adult cardiac function requires the chromatin factor Asxl2. J Mol Cell Cardiol Aug 27. pii: S (12) doi: /j.yjmcc [Epub ahead of print] PMID: PMIC NIHMSID# Henze M, Patrick SE, Hinken A, Scruggs SB, Goldspink P, de Tombe PP, Kobayashi M, Ping P, Kobayashi, Solaro RJ. New Insights Into the Functional Significance of the Acidic Region of the Unique N-Terminal Extension of Cardiac Troponin I. Biochimica Biophys Acta Mol 2012 Aug 25. pii: S (12) doi: /j.bbamcr [Epub ahead of print] PMID: Ke Y, Lei M, Wang X, Solaro RJ. Novel roles of Pak1 in the heart. Cell Logist Apr 1;2(2): PMID: PMCID:PMC

31 Monasky MM, Taglieri DM, Jacobson AK, Haizlip KM, Solaro RJ, and L. Janssen PML. Post-Translational Modifications of Myofilament Proteins Involved in Length- Dependent Prolongation of Relaxation in Rabbit Right Ventricular Myocardium. Arch Biochem Biophys 2012 Oct 18. pii: S (12) doi: /j.abb [Epub ahead of print] PMID: Jeong, E-M, Monasky MM, Gu L, Taglieri DM, Patel BG Liu H, Wang Q, Greener I, Dudley SC, Solaro RJ. Tetrahydrobiopterin Improves Diastolic Dysfunction by Reversing Changes in Myofilament Properties J Mol Cell Cardiol 2012 Dec 13. doi:pii: S (12) /j.yjmcc [Epub ahead of print] PMID: Schulz EM, Correll RN, Sheikh HN, Lofrano-Alves MS, Engel PL, Newman G, Schultz J J, Molkentin JD, Wolska BM, Solaro RJ, Wieczorek DF. Tropomyosin Dephosphorylation Results in Compensated Cardiac Hypertrophy. J Biol Chem Nov 12. [Epub ahead of print] PMID: Nixon BR, Liu B, Scellini B, Tesi C, Ogut O, Fishel R, Ziolo MT, Janssen PML, Solaro RJ, Davis JP, Poggesi C, Biesiadecki BJ. Tropomyosin Ser-283 pseudophosphorylation slows myofibril relaxation. Arch Biochem Biophys 2012 Dec 8. doi:pii: S (12) /j.abb [Epub ahead of print] PMID: Solaro RJ, Henze M, Kobayashi T. Integration of Troponin I Phosphorylation with Cardiac Regulatory Networks. Circ Res Circ Res Jan 18;112(2): doi: /CIRCRESAHA PMID: PubMed # NIHMSID # Publ.ID:RES Warren CM, Solaro RJ. Proteomics for Insights into Ventricular Arrhythmias. In: Chapter VI, Ventricular Arrhythmia From Principles to Patients (Editors: SC Dudley, Jr. A. A. Sovari, A.G. Kocheril) Nova Science Publishers pp Nagalingam RS, Sundaresan NR, Gupta MP, Geenen D, Solaro RJ, Gupta M. A cardiac enriched MicroRNA, mir-378, blocks cardiac hypertrophy by targeting Ras signaling. J Biol Chem Feb 27. [Epub ahead of print] PMID: Extramural Lectures: Over 300 invited extramural seminars and named distinguished lectures.