CURRICULUM VITAE/December, 2013

Transcription

1 CURRICULUM VITAE/December, 2013 NAME KNIP, Jan Mikael DATE AND PLACE OF BIRTH September 28, 1950, Kvevlax, Finland CITIZENSHIP Finland CURRENT RESIDENCE EDUCATION AND TRAINING M.D., University of Oulu, Oulu, Finland M.Sc.D. (Ph.D.), University of Oulu, Oulu, Finland Title of doctoral dissertation: Endocrine pancreatic function and its regulation in infants and children in normal and pathological conditions Speciality in Pediatrics, National Board of Health,, Finland Subspeciality in Pediatric Endocrinology, National Board of Health,, Finland Special competence in diabetology, Finnish Medical Association Docent in Pediatrics, University of Oulu LINGUISTIC SKILLS Mother tongue Other languages: CURRENT POSITIONS Professor of Pediatrics, Children s Hospital, University of Chief Physician, Children s Hospital, University Central Hospital Project Director, Department of Pediatrics, Tampere University Hospital October 10, 1976 May 24, 1983 September 30, 1985 November 20, 1989 May 15, 1995 April 1, 1989 Swedish Finnish (excellent) English (excellent) August 1, 2000August 1, 2000June 1, ESSENTIAL PREVIOUS PROFESSIONAL AND RESEARCH EXPERIENCE Research Associate, Medical Research Council, Academy of Finland, total 52 months House Officer, Department of Pediatrics, Oulu University Hospital, total 36months Postdoctoral Research Fellow, Division of Endocrinology, Research Institute of the Hospital for Sick Children, Toronto, Ontario, Canada, total 16 months Lecturer in Pediatrics, University of Oulu, total 22 months 1988 Secretary General/Scientist, Nordic Council for Arctic Medical Research, total 60 months Senior Scientist s Career Grant, Medical Research Council, Academy of Finland, Acting Professor of Pediatrics, Medical School, University of Tampere, Senior Scientist, Medical Research Council, Academy of Finland; Professor of Pediatrics, Medical School, University of Tampere, total 24 months Chair, Children s Hospital, University of, total 19 months total 91 months Senior Scientist, Medical Research Council, Academy of Finland; Dean, National Graduate School of Clinical Investigation, total 61 months MAJOR RESEARCH FUNDING OVER THE LAST 5 YEARS Medical Research Council, Academy of Finland - Nutritional prevention of childhood type 1 diabetes, 93,750 - Multidisciplinary approach for the control of gene-environment interactions causing allergy epidemic, 140,

2 - Nutritional prevention of childhood type 1 diabetes, 400, Center of Excellence (CoE) for Molecular Systems Immunology and Physiology, 360,000/year Tampere University Hospital - Prediction and prevention of type 1 diabetes, approximately ,000/year University Central Hospital - Pathogenesis of type 1 diabetes: From genetic susceptibility to clinical disease and its prevention, 60,000/year -Pathogenesis of type 1 diabetes: From genetic susceptibility to clinical disease and its prevention, 60,000/year - Pathogenesis of type 1 diabetes: From genetic susceptibility to clinical disease and its prevention, 38,300/year Novo Nordisk Foundation - Molecular pathogenesis of type 1 diabetes: From genetic susceptibility to clinical disease, 30,000-40,000/year Juvenile Diabetes Research Foundation (JDRF) - Characterization of beta-cell autoimmunity in preclinical type diabetes, USD 165,000/year - Validation of a metabolic signature protecting against type 1 diabetes, USD 110,000 Sigrid Juselius Foundation - Characterization of beta-cell autoimmunity in preclinical type diabetes, 80,000/year National Institute of Diabetes, Digestive and Kidney Diseases (NIDDK) - Early dietary intervention and later signs of beta-cell autoimmunity: Potential mechanisms, USD 1,851,860 National Institute of Child Health and Human Development (NICHD) - Trial to reduce IDDM in the genetically at risk (TRIGR), USD ,200,000/year EU, 7 th Framework - Pathogenesis of type 1 diabetes: Testing the hygiene hypothesis (DIABIMMUNE), 5,999,901 - Persistent virus infection as a cause of pathogenic inflammation in type diabetes (PEVNET), 362,400 MERITS IN TEACHING AND PEDAGOGICAL COMPETENCE - Responsible for the undergraduate course in pediatrics, University of Responsible for the specialist training in pediatrics, University of Dean, National Graduate School of Clinical Investigation, total 61 months Responsible for the undergraduate course in pediatrics, University of Tampere - Responsible for the specialist training in pediatrics, University of Tampere Pedagogic course in problem-based learning, University of Tampere 1996 Doctoral dissertations Supervisor for completed doctoral dissertations - Jukka Karjalainen, University of Oulu (together with Hans K. Åkerblom) Päivi Tapanainen, University of Oulu Outi Nuutinen, Universities of Kuopio and Oulu (together with 1992 Matti Uusitupa) - Kimmo Talvensaari, University of Oulu (together with Marjatta Lanning) Paula Vähäsalo, University of Oulu Riitta Veijola, University of Oulu (together with Jorma Ilonen) Tuija Löppönen, University of Oulu Johanna Rättyä, University of Oulu (together with Jouko Isojärvi) Jorma Komulainen, University of Kuopio (together with Hans K Åkerblom) - Emad Sabbah, University of Oulu Petri Kulmala, University of Oulu

3 - Kaisa Savola, University of Oulu Anu-Maaria Hämäläinen, University of Oulu Teija Kimpimäki, University of Tampere Päivi Riihimaa, University of Oulu (together with Päivi Tapanainen) Anna Toivonen, University of Tampere Sanna Hoppu, University of Tampere Matti Ronkainen, University of Oulu Virpi Pylvänen, University of Oulu (together with Jouko Isojärvi) Samy Mrena, University of Marika Kukko, University of Tampere (together with Päivi Keskinen) Liisa Uusitalo, University of Tampere (together with Suvi Virtanen) Anita Kondrashova, University of Tampere (together with Heikki Hyöty) Heli Siljander, University of Janne Nieminen, University of (together with Outi Vaarala) 2013 Supervisor for doctoral dissertations under preparation - Susanna Aspholm, University of - Anne Hekkala, University of Oulu (together with Riitta Veijola) - Eeva Jason, University of Tampere - Anna Parkkola, University of - Petra Pöllänen, University of - Kirsi Salonen, University of RESEARCH AWARDS AND HONORS Scholarship from the Medical Research Council of Canada Dissertation Award, Alma and K.A. Snellman Foundation, Oulu, Finland 1987 Knud Lundbaek Award, Scandinavian Society for the Study of Diabetes 1999 Maud Kuistila Award for Scientific Achievement 2004 The Medica Award for high quality and clinically important research 2006 within the field of pediatric internal medicine, Finska Läkaresällskapet Novo Nordisk Lecture, Scandinavian Society for the Study of Diabetes 2006 Research Award, European Society for Paediatric Endocrinology (ESPE) 2006 The Johnny Ludvigsson Award, the Swedish Child Diabetes Foundation 2010 Honorary Doctor, Medical Faculty, University of Tartu 2012 OTHER ACADEMIC AND PROFESSIONAL ACTIVITIES Pre-examiner of doctoral dissertations - Anna-Maija Haavisto, University of Turku Raija Anttila, University of Samu Sarna, University of Elina Hermanson, University of Helsnki Kaisa Karjalainen, University of Oulu Taina Härkönen, University of Eeva Löflund, University of Oulu Sini Laakso, University of k 2012 Opponent for doctoral dissertations - Ritva Sorri, University of Outi Mäkitie, University of Ekaterine Bakhtadze, Lund University, Sweden Marit Bjørnvold, University of Oslo, Norway Ilse Vermeulen, Free University Brussels, Belgium 2012 Reviewer of docent application - Leo Dunkel, University of Annelie Carlsson, Lund University, Sweden 2009 Reviewer of guest professor application - Stefano Cianfarani, Karolinska Institute 2012 Activities in scientific societies Scandinavian Society for the Study of Diabetes (SSSD) Member of the Board, President (1995) European Association for the Study of Diabetes (EASD) Council Member International Society for Pediatric and Adolescent Diabetes (ISPAD) Member, Advisory Council Immunology Diabetes Society (IDS)

4 - Treasurer Finnish Diabetes Research Society Member of the Board Finnish Society of Sciences and Letters, member Other scientific activities European Nicotinamide Diabetes Intervention Trial (ENDIT) Deputy Coordinator Medical Advisory Board, Finnish Diabetes Association - Member Vice-Chairman Chairman Scientific Committee, European Society for the Study of Diabetes - 31 st Annual Meeting, Stockholm nd Annual Meeting, Vienna nd Annual Meeting, Copenhagen 2006 Scientific Program Committee, 16 th International Diabetes Federation Congress,, Finland, July 20-25, Vice-Chairman Biomed 2 - Scientific evaluator 1995 JDRF Medical Science Review Committee - Member Research Council, University of - Member Research Council, Faculty of Medicine, University of - Member Diabetes Prediction and Prevention Study (DIPP) - Principal Investigator (PI), one of three PIs Trial to Reduce IDDM in the Genetically at Risk (TRIGR) - Deputy PI PI Finnish Pediatric Diabetes Register and Biobank - PI The Environmental Determinants of Diabetes in the Young (TEDDY) - Local PI Research Council for Health, Academy of Finland - Member Vice Chair DIAMAP Road Map for Diabetes Research in Europe, Focused Sub-Group on Genetics and Epidemiology - Member DIABIMMUNE Collaborative Project - PI Data Safety Monitoring Board (DSMB), European and North American Trials with the diabetes vaccine Diamyd - Member Finnish Centre of Excellence in in Molecular Systems Immunology and Physiology Research - Deputy Director Novo Nordisk Foundation - Member of Nordisk forskningskomite Diabetes and Obesity Research Program, Medical Faculty, University of - Director Editorial Board membership Arctic Medical Research, Managing Editor International Growth Monitor, Review Editor European Journal of Endocrinology, Editor Journal of Clinical Endocrinology and Metabolism, Editorial Board Member Pediatric Diabetes, Editorial Board Member Lancet Diabetes & Endocrinology, Editorial Board Member

5 Referee for scientific journals Acta Paediatrica, Autoimmunity, British Medical Journal, Clinical Endocrinology, Diabetes, Diabetes Care, Diabetes/Metabolism Research and Reviews, Diabetic Medicine, Diabetologia, European Journal of Clinical Investigation, European Journal of Clinical Nutrition, European Journal of Endocrinology, European Journal of Pediatrics, FASEB Journal, Human Immunology, Journal of the American Medical Association (JAMA), Journal of Clinical Endocrinology and Metabolism, Journal of Clinical Investigation, Journal of Pediatrics, Lancet, Nature Reviews Endocrinology, Pediatric Diabetes, Pediatric Research, Pediatrics, PLoS One, Trends in Molecular Medicine SCIENTIFIC AND SOCIAL IMPACT OF RESEARCH Publications 490 original papers, 34 manuscripts, 72 reviews and editorials, 71 other publications, and 509 abstracts (please see separate list) H-index: 63 Citations: 14,734 Patents or patent applications Hyöty M, Knip M. Prevention of type 1 diabetes and other non-polio enterovirus diseases. European patent Viskari H, Knip M, Seiskari T, Hyöty H, Kummola L, Kondrashova A. Prevention of allergic sensitization. PCT WO2008/ Hyöty H, Knip M, Laitinen O, Tolonen O, Pulkki M, Oikarinen S, Honkanen H-R, Lecouturier V, Almond J. Enterovirus vaccines for preventing or treating type 1 diabetes (I). European patent application Hyöty H, Knip M, Laitinen O, Tolonen O, Pulkki M, Oikarinen S, Honkanen H-R, Lecouturier V, Almond J. Diagnostic assay for type 1 diabetes. PCT application PCT/EP2011/ Spin-off company Vactech Ltd, aims at developing picornavirus vaccines, an antidiabetogenic enterovirus vaccine,in particular - Board member POSITIONS OF TRUST IN SOCIETY AND OTHER SOCIAL MERITS - Vasa nation, Inspector The Association of Friends of the University Children's Hospitals, board member - UNICEF Finland, board member