Italian Pisa, 20 February 1961

Transcription

1 C U R R I C U L U M V I T A E F O R M A T O E U R O P E O / E U R O P E A N F O R M A T INFORMAZIONI PERSONALI/ PERSONAL INFORMATION Nome, Cognome/Name, Surname Indirizzo/Address Via, numero civico, c.a.p., città, nazione/ House number, street name, postcode, city, country Andrea Natali Via Brodolini, Pisa Italy Telefono/Telephone Sito web/website Nazionalità/Nationality Luogo e data di nascita/ Place and Date of birth Fax [email protected] Italian Pisa, 20 February 1961 ESPERIENZA PROFESSIONALE /WORK EXPERIENCE In ordine di data /Dates (from to) [Iniziare con le più recenti ed elencare separatamente ciascun incarico ricoperto/ Add separate entries for each relevant post occupied, starting with the most recent. ] 2007-Today Associate professor of Internal Medicine Research Investigator University of Pisa Research Investigator CNR Institute of Clinical Physiology Nome e indirizzo del datore di lavoro / Name and address of employer Tipo o settore di attività / Type of business or sector Funzione o posto occupato / Occupation or position held Principali mansion e responsabilità / Main activities and responsibilities Università di Pisa, Lungarno Pacinotti 43, Pisa Teaching, clinical activities and clinical investigation Associate professor Responsible for inpatient and outpatient clinic for metabolic diseases. Page 1 - Curriculum vitae

2 ISTRUZIONE E FORMAZIONE / EDUCATION AND TRAINING In ordine di data /Dates (from to) [Iniziare con le più recenti ed elencare separatamente ciascun corso frequentato con successo/ Add separate entries for each relevant course you have completed, starting with the most recent. ] Nome e tipo d istituto di istruzione o formazione / Name and type of organisation providing education and training Principali materie e competenze professionali apprese / Principal subjects occupational skills covered Certificato o diploma ottenuto /Title of qualification awarded Livello nella classificazione nazionale o internazionale / Level in National classification 1995 Specialty in Internal medicine 1990 Specialty in Nuclear medicine 1987 Degree in Medicine University of Pisa Clinical investigation and teaching in metabolic diseases ATTIVITA DI RICERCA / RESEARCH ACTIVITIES Attuali campi di ricerca / Research sectors Recenti attività scientifiche/ Recent Scientific Activities. 1) epidemiology and pathophysiology of vascular complications in diabetes and hypertension. 2) pathophysiology of insulin resistance in relation to cardiovascular risk factors and endothelial dysfunction. 3) pathophysiology of ß cell dysfunction. Participation to collaborative projects funded by EU agencies (FP5 EU project RISC and the ongoing IMI initiative sponsored SUMMIT project). Page 2 - Curriculum vitae

3 Pubblicazioni/ Books and Articles last 7 years Page 3 - Curriculum vitae 1. Caraccio N, Natali A, Sironi A, Baldi S, Frascerra S, Dardano A, Monzani F, Ferrannini E: Muscle metabolism and exercise tolerance in subclinical hypothyroidism: a controlled trial of levothyroxine. J Clin Endocrinol Metab 90: , Mari A, Gastaldelli A, Natali A, Ostergard T, Schmitz O, Ferrannini E: Characterization of beta cell function impairment in first degree relatives of type 2 diabetic subjects: modeling analysis of 24 h triple meal tests. Am J Physiol Endocrinol Metab 288:E , Natali A, Toschi E, Baldeweg S, Casolaro A, Baldi S, Sironi AM, Yudkin JS, Ferrannini E: Haematocrit, type 2 diabetes, and endothelium dependent vasodilatation of resistance vessels. Eur Heart J 26: , Basta G, Sironi AM, Lazzerini G, Del Turco S, Buzzigoli E, Casolaro A, Natali A, Ferrannini E, Gastaldelli A: Circulating soluble receptor for advanced glycation end products is inversely associated with glycemic control and S100A12 protein. J Clin Endocrinol Metab 91: , Femia R, Natali A, L'Abbate A, Ferrannini E: Coronary Atherosclerosis and Alcohol Consumption. Angiographic and Mortality Data. Arterioscler Thromb Vasc Biol, Manco M, Nolfe G, Calvani M, Natali A, Nolan J, Ferrannini E, Mingrone G: Menopause, insulin resistance, and risk factors for cardiovascular disease. Menopause 13: , Muscelli E, Mari A, Natali A, Astiarraga BD, Camastra S, Frascerra SD, Holst JJ, Ferrannini E: Impact of incretin hormones on {beta} cell function in subjects with normal or impaired glucose tolerance. Am J Physiol Endocrinol Metab, Natali A, Ferrannini E: Effects of metformin and thiazolidinediones on suppression of hepatic glucose production and stimulation of glucose uptake in type 2 diabetes: a systematic review. Diabetologia 49: , Natali A, Toschi E, Baldeweg S, Ciociaro D, Favilla S, Sacca L, Ferrannini E: Clustering of insulin resistance with vascular dysfunction and low grade inflammation in type 2 diabetes. Diabetes 55: , Baldi S, Frascerra S, Ferrannini E, Natali A: LDL resistance to oxidation: Effects of lipid phenotype, autologous HDL and alanine. Clin Chim Acta 379:95 100, Ferrannini E, Balkau B, Coppack SW, Dekker JM, Mari A, Nolan J, Walker M, Natali A, Beck Nielsen H: Insulin resistance, insulin response, and obesity as indicators of metabolic risk. J Clin Endocrinol Metab 92: , Ferrannini E, Muscelli E, Natali A, Gabriel R, Mitrakou A, Flyvbjerg A, Golay A, Hojlund K: Association of fasting glucagon and proinsulin concentrations with insulin resistance. Diabetologia 50: , Neglia D, De Caterina A, Marraccini P, Natali A, Ciardetti M, Vecoli C, Gastaldelli A, Ciociaro D, Pellegrini P, Testa R, Menichetti L, L'Abbate A, Stanley WC, Recchia FA: Impaired myocardial metabolic reserve and substrate selection flexibility during stress

4 Page 4 - Curriculum vitae in patients with idiopathic dilated cardiomyopathy. Am J Physiol Heart Circ Physiol 293:H , Lubrano V, Baldi S, Ferrannini E, L'Abbate A, Natali A: Role of thromboxane A2 receptor on the effects of oxidized LDL on microvascular endothelium nitric oxide, endothelin 1, and IL 6 production. Microcirculation 15: , Bonora E, Capaldo B, Perin PC, Del Prato S, De Mattia G, Frittitta L, Frontoni S, Leonetti F, Luzi L, Marchesini G, Marini MA, Natali A, Paolisso G, Piatti PM, Pujia A, Solini A, Vettor R, Bonadonna RC: Hyperinsulinemia and insulin resistance are independently associated with plasma lipids, uric acid and blood pressure in nondiabetic subjects. The GISIR database. Nutr Metab Cardiovasc Dis 18: , Natali A, Baldi S, Vittone F, Muscelli E, Casolaro A, Morgantini C, Palombo C, Ferrannini E: Effects of glucose tolerance on the changes provoked by glucose ingestion in microvascular function. Diabetologia 51: , Sesti G, Andreozzi F, Bonadonna RC, De Mattia G, Leonetti F, Luzi L, Marini MA, Natali A, Vettor R, Bonora E: Impact of lowering the criterion for impaired fasting glucose on identification of individuals with insulin resistance. The GISIR database. Diabetes Metab Res Rev 24: , Gastaldelli A, Natali A, Vettor R, Corradini SG: Insulin resistance, adipose depots and gut: interactions and pathological implications. Dig Liver Dis 42: , Ferrannini E, Massari M, Nannipieri M, Natali A, Ridaura RL, Gonzales Villalpando C: Plasma glucose levels as predictors of diabetes: the Mexico City diabetes study. Diabetologia 52: , Natali A, Muscelli E, Casolaro A, Nilsson P, Melander O, Lalic N, Ferrannini E, Petrie JR: Metabolic characteristics of prehypertension: role of classification criteria and gender. J Hypertens, Gall WE, Beebe K, Lawton KA, Adam KP, Mitchell MW, Nakhle PJ, Ryals JA, Milburn MV, Nannipieri M, Camastra S, Natali A, Ferrannini E: alpha hydroxybutyrate is an early biomarker of insulin resistance and glucose intolerance in a nondiabetic population. PLoS One 5:e10883, Di Marco S, Boldrini B, Conti U, Marcucci G, Morgantini C, Ferrannini E, Natali A: Effects of GIK (glucose insulin potassium) on stress induced myocardial ischaemia. Clin Sci (Lond) 119:37 44, Mari A, Tura A, Natali A, Laville M, Laakso M, Gabriel R, Beck Nielsen H, Ferrannini E: Impaired beta cell glucose sensitivity rather than inadequate compensation for insulin resistance is the dominant defect in glucose intolerance. Diabetologia 53: , Ferrannini E, Natali A, Muscelli E, Nilsson PM, Golay A, Laakso M, Beck Nielsen H, Mari A: Natural history and physiological determinants of changes in glucose tolerance in a non diabetic population: the RISC Study. Diabetologia 54: , 2011

5 25. Rebelos E, Muscelli E, Natali A, Balkau B, Mingrone G, Piatti P, Konrad T, Mari A, Ferrannini E: Body Weight, Not Insulin Sensitivity or Secretion, May Predict Spontaneous Weight Changes in Nondiabetic and Prediabetic Subjects: The RISC Study. Diabetes 60: , Mari A, Tura A, Natali A, Anderwald C, Balkau B, Lalic N, Walker M, Ferrannini E: Influence of Hyperinsulinemia and Insulin Resistance on In Vivo beta Cell Function: Their Role in Human beta Cell Dysfunction. Diabetes, 2011 (in press) 27. Morgantini C, Natali A, Boldrini B, Imaizumi S, Navab M, Fogelman AM, Ferrannini E, Reddy ST: Anti inflammatory and antioxidant properties of HDLs are impaired in type 2 diabetes. Diabetes 60: , Morgantini C, Stea F, Boldrini B, Duranti E, Ghiadoni L, Natali A: Effect of mild hyperisulinemia on conduit vessel endothelial function: role of noradrenergic activation. Journal of hypertension 30: , Natali A, Santini E, Delbarba A, Baldi S, Venturi E, Tulipani A, Nisoli E, Ferrannini E: Effects of short and prolonged mild intracellular nitric oxide manipulations on various aspects of insulin secretion in INS 1E beta cells. Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association 120: , 2012 ULTERIORI INFORMAZIONI / ADDITIONAL INFORMATION Page 5 - Curriculum vitae

6 TRATTAMENTO DEI DATI PERSONALI, INFORMATIVA E CONSENSO Il D.Lgs. 30/6/2003, n. 196 Codice in materia di protezione dei dati personali regola il trattamento dei dati personali, con particolare riferimento alla riservatezza, all identità personale e al diritto di protezione dei dati personali; l interessato deve essere previamente informato del trattamento. La norma in considerazione intende come trattamento qualunque operazione o complesso di operazioni concernenti la raccolta, la registrazione, l organizzazione, la conservazione, la consultazione, l elaborazione, la modifica, la selezione, l estrazione, il raffronto, l utilizzo, l interconnessione, il blocco, la comunicazione, la diffusione, la cancellazione e la distruzione di dati, anche se non registrati in una banca dati. In relazione a quanto riportato, autorizzo il CNR al trattamento dei dati contenuti nel presente curriculum vitae e nella documentazione della quale fa parte integrante ( barrare la casella) x Si, acconsento Page 6 - Curriculum vitae