Europass Curriculum Vitae

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1 Europass Curriculum Vitae Personal information First name(s) / Surname(s) Address Via Moruzzi,1, Pisa (Italy) Telephone(s) Mobile Fax(es) (s) [email protected] Nationality italian Date of birth 06/02/1963 Gender Desired employment / Occupational field Female clinical research Work experience Dates Dates 2009 associated research investigator Cardiometabolic Risk Unit- Institute of Clinical PhysiologyCardiometabolic Risk Unit Via Moruzzi 1, Pisa (Italy) National Reasearch Council 2008 Medical doctor Metabolic specialistic outpatient Clinic Via del Brennero 344/g, Lucca (Italy) Professional (Medical Doctor) Dates full staff in the Magnetic Resonance Laboratory in Institute of Clinical Physiology Anesthesiologist Institute of Clinical Physiology Via Moruzzi,1, Pisa (Italy) Dates Full Staff Internist: metabolic outpatient Clinic the Institute of Clinical Physiology Via Moruzzi,1, Pisa (Italy) Dates clinical researcher Page 1 / 5 - Curriculum vitae of

2 Research Fellow Metabolism Unit-Institute of Clinical Physiology Via Moruzzi 1, Pisa (Italy) Education and training Personal skills and competences Dates 08/ /1995 Visiting Scientist Research Fellow Department of Endocrinoly and Metabolism Prf Sherwin, Yale University, Connecticut, USA University Dates Postgraduate: Internal Medicine Metabolism, Energy expenditure, Insulin resistance, Diabetes Obesity Department of Internal Medicine (University) Dates Dates 1989 Postgraduate: Anesthesia and Resuscitation, Surgery Intensive Care Unit Clinica Chirurgica (University) Laurea in Medicine and Surgery Pharmacolgy Medical School (University) Mother tongue(s) Italian Other language(s) Self-assessment Understanding Speaking W r i t i n g European level (*) Listening Reading Spoken interaction Spoken production English C1 Proficient user C1 Proficient user B2 Independent user B2 Independent user B2 Independent user French B1 Independent user B1 Independent user A2 Basic User A2 Basic User A2 Basic User (*) Common European Framework of Reference (CEF) level Driving licence(s) Annexes B List of publications PUBLICATIONS: Page 2 / 5 - Curriculum vitae of

3 1. Agen C, Sironi AM, Danesi R, Costa M, Bernardini N, Paparelli A, Della Torre P, Del Tacca M Characterization of the toxicity distamycin derivatives on cancer cell lines and rat heart. Toxicology 1992, 75: Quinones Galvan A, Brandi LS, Sironi AM, Ciociaro D, Frascerra S, Buzzigoli G, Ferrannini E Effect of insulin and total parenteral nutrition on circulating amino acids in the postoperative period. Diabetes, Nutrition and Metabolism 1992, 6: Oleggini M, Consani G, Fossati N, Sironi AM Influenza del brivido postoperatorio sul ph gastrico intramucoso e sull acidosi lattica. Acta Anaesthesiologica Italica 1992, 43: Brandi LS, Sironi AM, Baldassari R, Benati F, Giunta F. Effetti emodinamici e metabolici della infusione di noradrenalina in un caso di shock iperdinamico. Minerva Anestesiologica 1994, 60: Brandi LS, Giunta F, Sironi AM, Natali E, and Ferrannini E Lung fluxes of lactate, pyruvate and other energy blood-borne substrates during surgical stress. Applied Cardiopulmonary Pathophysiology 1995, 5: Brandi LS, Giunta F, Pieri M, Sironi AM, Mazzanti T Venous-arterial pco2 and ph gradients in acutely ill post-surgical patients. Minerva Anestesiologica 1995, 61: Baldi S, Natali A, Buzzigoli G, Quiñones Galvan A, Sironi AM, and Ferrannini E In vivo effect of insulin on intracellular calcium concentrations: relation to insulin resistance. Metabolism 1996, 45(11): Muscelli E, Natali A, Bianchi S, Bigazzi R, Quiñones Galvan A, Sironi AM, Frascerra S, Ciociaro D, and Ferrannini E Effect of insulin on renal sodium and uric acid handling in patients with essential hypertension. American Journal of Hypertension 1996, 9: Muscelli E, Camastra S, Baldi S, Masoni A, Sironi AM, Natali A, and Ferrannini E Acute insulin administration does not affect plasma leptin levels in lean or obese subjects. European Journal of Clinical Investigation 1996, 26: Sironi AM, Vichi S, Gastaldelli A, Pecori N, Anichini R, Foot EA, Seghieri G and Ferrannini E Effects of Troglitazone on Insulin Action and Cardiovascular Risk Factors in NIDDM patients. Clinical Pharmacology and Therapeutics 1997, 62: Masini M, Sironi AM La cardiomiopatia diabetica. Medicina e Cultura 1997, 22: Seghieri G, Sani S, Breschi MC, Sironi AM, Mohamed-Ali V, Andres C, Yudkin JS, Ferrannini E Relation of birthweight to markers of foeto-maternal beta-cell function. Diabetes Nutrition and Metabolism, 1997, 10: Sironi AM, and Ferrannini E. Pathophysiology of heart failure in diabetic patients. Medicographia 1997, 55(19): Cominacini L, Garbin U, Fratta Pasini A, Campagnola M, Davoli A, Foot E, Seghieri G, Sironi AM, Lo Cascio V, Ferrannini E Troglitazone reduces LDL oxidation and lowers plasma E-selectin concentration in NIDDM patients. Diabetes 1998, 47: Natali A, Gastaldelli A Quiñones Galvan A, Sironi AM,, Ciociaro D, Sanna G, Rosenzweig P, Ferrannini E Effects of acute alpha-2 blockade on insulin secretion, glucose metabolism, and thermogenesis in humans. American Journal of Physiology 1998, Quiñones Galvan A, Sironi AM, Baldi S, Galetta F, Garbin U, Fratta-Pasini A, Cominacini L, Ferrannini E. Evidence that acute insulin administration enhances LDL-cholesterol susceptibility to oxidation in healthy humans. Arterioscl Thromb Vasc Biol 1999, 19: Ferrannini E, Galvan AQ, Gastaldelli A, Camastra S, Sironi AM, Toschi E, Baldi S, Frascerra S, Monzani F, Antonelli A, Nannipieri M, Mari A, Seghieri G, Natali A, Insulin: new roles for an ancient hormone. Eur J Clin Invest Oct; 29 (10) : Review 17. Natali A, Sironi AM, Toschi E, Camastra S, Sanna G, Perissinotto A, Taddei S, Ferrannini E Effect of vitamin C on forearm blood flow and glucose metabolism in insulin resistant essential hypertensives. Arterioscl Thromb Vasc Biol 2000, 20: Natali A, Gastaldelli A, Camastra S, Sironi AM, Toschi E, Masoni A, Ferrannini E, Mari A Doseresponse characteristics of insulin action on glucose metabolism: a non-steady-state approach. Am J Physiol Endocrinol Metab. 2000, 278:E Quiñones Galvan A, Galetta F, Natali A, Muscelli E, Sironi AM, Cini G, Camastra S, Ferrannini E Insulin Resistance and Hyperinsulinemia. No independent relation to left ventricular mass in humans. Circulation 2000, 102: Gastaldelli A, Toschi E, Pettiti M, Frascerra S, Quiñones Galvan A, Sironi AM, Natali A, Ferrannini Page 3 / 5 - Curriculum vitae of

4 Effect of physiological hyperinsulenimia on gluconeogensis in non diabetic subjects and in type 2 diabetic patients. Diabetes 2001, 50: Toschi E, Camastra S, Sironi AM, Masoni A, Gastaldelli A, Mari A, Ferrannini E, Natali A, Effect of acute hyperglycemia on insulin secretion in humans. Diabetes 2002, 51:S130-S Sironi AM, Gastaldelli A, Mari A, Ciociaro D, Buzzigoli E, Pettiti M, Positano V, Lombardi M, Ferrannini E, Visceral fat accumulation in nondiabetic subjects is associated with reduced insulin sensitivity but normal beta cell function. Hypertension 2004 Aug; 44 (2): Positano V, Gastaldelli A, Sironi AM, Santarelli MF, Lombardi M, Landini L, An accurate and robust method for unsupervised assessment of abdominal fat by MRI. J Magn Reson Imaging 2004 Oct; 20 (4) : Ferrannini E, Camastra S, Gastaldelli A, Sironi AM, Natali A, Muscelli E, Mingrone G, Mari A, Beta- Cell function in Obesity. Effect of Weight loss. Diabetes, Dec 2004, vol. 53, suppl. 3 (26 33) 25. Natali A, Toschi E, Baldeweg S, Casolaro A, Baldi S, Sironi AM, Yudkin JS, Ferrannini E, Haematocrit, type 2 diabetes, and endothelium-dependent vasodilatation of resistance vessels. Eur Heart J Mar; 26(5): epub 2005 feb Caraccio N, Natali A, Sironi AM, Baldi S, Frascerra S, Dardano A, Monzani F, Ferrannini E, Muscle metabolism and exercise tolerance in subclinical hypothyroidism: a controlled trial of levothyroxine. J Clin Endocrinol Metab Apr 26, 27. Gastaldelli A, Sironi AM, Ciociaro D, Positano V, Buzzigoli E, Giannessi D, Lombardi M, Mari A and Ferrannini E, Visceral fat and beta-cell function in non diabetic humans. Diabetologia, 2005; 48(10): Passino C, Sironi AM, Favilli B, Poletti R, Prontera C, Ripoli A, Lombardi M, Emdin M, Right heart overload contributes to cardiac natriuretic hormone elevation in patients with heart failure. International Journal of Cardiology, 2005 Sep 15;104(1): Basta G, Sironi AM, Lazzerini G, Del Turco S, Buzzigoli E, Casolaro A, Natali A, Ferrannini E, Gastaldelli A, Circulating soluble receptor for advanced glycation end products is inversely associated with glycemic control and S100A12 protein. J Clin Endocrinol Metab Nov;91(11): Gastaldelli A, Cusi K, Pettiti M, Hardies J, Miyazaki Y, Berria R, Buzzigoli E, Sironi AM, Cersosimo E, Ferrannini E, Defronzo RA, Relationship between hepatic/visceral fat and hepatic insulin resistance in nondiabetic and type 2 diabeticsubjects. Gastroenterology Aug;133(2): Ferrannini E, Sironi AM, Iozzo P, Gastaldelli A: "Intra-abdominal adiposity, abdominal obesity and cardiometabolic risk." (Eur Heart J Suppl 10:B4-B10, 2008) IF= Positano V, Cusi K, Santarelli MF, Sironi A, Petz R, Defronzo R, Landini L, Gastaldelli A: "Automatic correction of intensity inhomogeneities improves unsupervised assessment of abdominal fat by MRI." (J Magn Reson Imaging 28: , 2008) IF= Sironi AM, Pingitore A, Ghione S, De Marchi D, Scattini B, Positano V, Muscelli E, Ciociaro D, Lombardi M, Ferrannini E, Gastaldelli A: "Early hypertension is associated with reduced regional cardiac function, insulin resistance, epicardial, and visceral fat." (Hypertension 51: , 2008) IF= Sicari R, Sironi AM, Petz R, Frassi F, Chubuchny V, De Marchi D, Positano V, Lombardi M, Picano E, Gastaldelli A. Pericardial Rather Than Epicardial Fat Is a Cardiometabolic Risk Marker: An MRI vs Echo Study. J Am Soc Echocardiogr (10): Sironi AM, Sicari R, Folli F, Gastaldelli A. Ectopic fat storage, insulin resistance, and hypertension. Curr Pharm Des. 2011;17(28): Sironi AM, Petz R, De Marchi D, Buzzigoli E, Ciociaro D, Positano V, Lombardi M, Ferrannini E, Gastaldelli A. Impact of increased visceral and cardiac fat on cardiometabolic risk and disease. Diabet Med Oct 24. doi: /j x. [Epub ahead of print] PubMed PMID: Page 4 / 5 - Curriculum vitae of BOOK CHAPTERS 1. Sironi AM. "Prognosi del Diabete Mellito" in Il Diabete, Collana I Quaderni del C.N.R. Primula editrice, Pisa, Sironi A.M. e Masini M. "La Cardiomiopatia Diabetica in Cuore e Diabete, Collana I Quaderni del C.N.R. Primula editrice, Pisa, Quiñones AG., Iascone M.R., Sironi A.M. Recenti acquisizioni di genetica, fisiopatologia e terapia

5 in Cuore e Diabete, Collana I Quaderni del C.N.R. Primula editrice, Pisa, Lombardi M, Sironi AM, Monti L, Deiana M, Ghedin P. Heart morphology in MRI of the Heart and Vessels, Springer- Verlag Italia Editori, Milano Sironi AM, Lombardi M, Pepe A, De Marchi D. Study of heart function in MRI of the Heart and Vessels, Springer- Verlag Italia Editori, Milano 2005 Page 5 / 5 - Curriculum vitae of

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