INVITATION. INTERNATIONAL CONFERENCE TO CELEBRATE THE 50 th ANNIVERSARY OF HUNGARIAN SOCIETY FOR EXPERIMENTAL AND CLINICAL PHARMACOLOGY PROGRAM

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1 INVITATION INTERNATIONAL CONFERENCE TO CELEBRATE THE 50 th ANNIVERSARY OF HUNGARIAN SOCIETY FOR EXPERIMENTAL AND CLINICAL PHARMACOLOGY PROGRAM September 19 21, 2012 Hungarian Academy of Sciences, Budapest, Hungary

2 Venues September 19: The Main Building of the Hungarian Academy of Sciences, Budapest, 1051 Budapest, Széchenyi István tér 9. web site: September 20 21: Hotel Sofitel Budapest Chain Bridge, 1051 Budapest, Széchenyi István tér 2. web site: budapest.com Main Patrons József Pálinkás, President, Hungarian Academy of Sciences Zoltán Balog, Minister of Human Resources Patron László Vécsei, President, Section of Medical Sciences of the Hungarian Academy of Sciences Ágoston Szél, rector, Semmelweis University Organization Committee Zsuzsanna Fürst chair Beáta Sperlágh Kornélia Tekes Ádám Vas Valéria Kecskeméti Klára Gyires Hungarian Society for Experimental and Clinical Pharmacology Conference website: 2

3 PROGRAM Wednesday Lecture Hall of the Main Building of Hungarian Academy of Sciences Opening ceremony Lectures Welcome addresses Ingolf Cascorbi, representative of IUPHAR Thomas Griesbacher, General Secretary of EPHAR Folke Sjöquist, representative of EACPT László Vécsei, President, Section of Medical Sciences of the Hungarian Academy of Sciences Tibor Ertl, President, Association of Hungarian Medical Society MOTESZ Zoltán Vincze, President, Hungarian Society for Pharmaceutical Sciences László Hunyady, President, Hungarian Physiological Society Péter Gaszner, President, Hungarian Association for Psychopharmacologists László Fésüs, President, Hungarian Biochemical Society Béla Merkely, President, Hungarian Society of Cardiology István Kiss, President, Hungarian Society of Hypertension Honorary member ceremonies Thomas Griesbacher, Dirk van Helden, Pál Pacher, Patrizia Romualdi, Vinod P. Shah, Sándor Szabó József Knoll Member of the Hungarian Academy of Sciences founder and honorary president for life of the Hungarian Society for Experimental and Clinical Pharmacology 3

4 The enhancer regulation in the mammalian brain. Synthetic enhancer substances: deprenyl/selegiline and R ( ) 1 (benzofuran 2 yl) 2 propylaminopentane / ( ) BPAP E. Sylvester Vizi Former president of the Hungarian Academy of Sciences former president of the Hungarian Society for Experimental and Clinical Pharmacology From the bioassay of acetylcholine to the two photon laser scanning microscopy Ingolf Cascorbi Chair of the Pharmacogenetics Section of IUPHAR Pharmacogenomics and Epigenomics of Drug Resistance Music performance Semmelweis Chamber Orchestra Opera arias by pupils of Éva Marton Hotel Sofitel, Terrasse Restaurant Reception 4

5 Thursday Hotel Sofitel, Vaszary Hall I. EPHAR Symposium: Neurodegeneration Organizer/Chair: Kálmán Magyar and Peter Riederer Peter Riederer Clinic and Policlinic for Psychiatry, Psychosomatic and Psychotherapy, University of Würzburg, Würzburg, Germany Unilateral onset of Parkinson s disease triggered by developmental disturbances? Moussa Youdim Technion Rappaport Family Faculty of Medicine, Eve Topf and US National Parkinson Foundation Centers of Excellence for Neurodegenerative Diseases, Haifa, Israel Why neuroprotective neurorestorative multi target for neurodegenerative disorders? Heinz Reichmann Department of Neurology, University of Dresden, Dresden, Germany Where does Parkinson's Disease start? László Vécsei Department of Neurology, University of Szeged, Szeged, Hungary Kynurenines: possible drug development strategies for the treatment of CNS disorders 5

6 Coffee break II. New trends in antinociceptive therapy Organizer/Chair: Zsuzsanna Fürst and János Szolcsányi Patrizia Romualdi Department of Pharmacology, University of Bologna, Bologna, Italy Does addiction occur in opiate pain treatment? Zsuzsanna Fürst Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary My way: Opioid Research János Szolcsányi Department of Pharmacology and Pharmacotherapy, University of Pécs, Pécs, Hungary Advent of a new chapter of analgesics Lunch break III. New drug targets in CNS disorders Organizer/Chair: Beáta Sperlágh and Peter Illes 6

7 Maria Pia Abbracchio Department of Pharmacological Sciences, University of Milan, Milan, Italy The dual purinergic/cysteinyl leukotriene receptor GPR17 as a new therapeutic target for demyelinating diseases Peter Illes Rudolf Boehm Institut für Pharmakologie und Toxikologie der Universität Leipzig, Leipzig, Germany P2X3 receptors; a new pharmacological target for the treatment of inflammatory and neuropathic pain Beáta Sperlágh Institute of Experimental Medicine, Hungarian Academy of Sciences, Budapest, Hungary P2Y12 receptor antagonists: new potential CNS indications beyond the antithrombotic effect Coffee break IV. Cardiovascular pharmacology Organizer/Chair: András Varró and Peter Ferdinandy Pál Pacher National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Rockville, Maryland, USA Role of the endocannabinoid system and natural nonpsychoactive cannabinoids in diabetic cardiovascular complications 7

8 András Varró Department of Pharmacology and Pharmacotherapy, University of Szeged, Szeged, Hungary Possible new mechanisms of arrhythmia therapy Peter Ferdinandy Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary Cardioprotection in hyperlipidemia: role of inhibition of matrix metalloproteinase activity V. Gastrointestinal/smooth muscle pharmacology Organizer/Chair: Klára Gyires and Loránd Barthó Sándor Szabó School of Medicine, University of California, Irvine, VA Long Beach Healthcare System, Long Beach, CA, USA Novel pharmacologic approaches to treat gastrointestinal ulcers Dirk F. van Helden The Neuroscience Group, School of Biomedical Sciences and Pharmacy, The University of Newcastle, Callaghan, New South Wales 2308, Australia Slow wave rhythmicity and propagation in gastric smooth muscle 8

9 Klára Gyires Department of Pharmacology and Pharmacotherapy, Semmelweis University, Budapest, Hungary Gastric mucosal defense: from periphery to CNS Loránd Barthó Department of Pharmacology and Pharmacotherapy, University of Pécs, Pécs, Hungary In vitro smooth muscle effects of compounds acting at TRP channels Friday Hotel Sofitel, Vaszary Hall VI. Pharmacokinetics and drug metabolism Organizer/Chair: Imre Klebovich and Huba Kalász Vinod P. Shah International Pharmaceutical Federation, SIG, Chair of Regulatory Sciences Pharmacokinetics in Drug Development and Regulations Georg Petroianu Department of Cellular Biology & Pharmacology, Herbert Wertheim College of Medicine, Florida International University, Miami, FL, USA 9

10 Pyridinium Oximes for Reactivation of Phosphylated Cholinesterases: Is [clinical] disappointment rooted in pharmacokinetics? Huba Kalász Department of Pharmacology and Pharmacotherapy and Department of Pharmacodynamics, Semmelweis University, Budapest, Hungary Regulation of Blood Brain Barrier penetration of polar organic compounds: Rules and Facts Coffee break VII. Clinical pharmacology Organizer/Chair: Csaba Farsang and Ádám Vas Folke Sjöquist Department of Laboratory Medicine, Division of Clinical Pharmacology, Karolinska Institutet, Karolinska University Hospital, Stockholm, Sweden Forty years with clinical pharmacology in research, teaching and health care Gonzalo Calvo Rojas Department of Clinical Pharmacology, Hospital Clinic, University of Barcelona (UB), Barcelona, Spain The new EU regulatory framework. Practical implications for drug evaluation 10

11 Csaba Farsang Cardiometabolic Center, Department of Internal Medicine, St Imre Hospital, Budapest, Hungary What we have learned and what we did not from clinical trials? Closing remarks TECHNICAL INFORMATION Lectures will be held in the Lecture Hall on the 2 nd floor of the Main Building of the Hungarian Academy of Sciences, and in the Vaszary Hall on the Basement of the Hotel Sofitel. For speakers, LCD projector and a laptop with Windows XP Professional will be provided. 11

12 SPONSORS 12