Intracellular Calcium and Phosphatidylserine Exposure in the red Blood Cells
|
|
- Quentin Thompson
- 7 years ago
- Views:
Transcription
1 Intracellular Calcium and Phosphatidylserine Exposure in the red Blood Cells Biotechnology Seminar 2 Yaser Alkhaled
2 Table of Content 1. Introduction Membrane of red blood cell Exposure of phosphatidylserine and intracellular ca References
3 1. Introduction Erythrocytes differentiated from stem cells in bone marrow through process named erythropoiesis to form mature RBCs. Erythrocytes initiate their formation in the yolk sac (3 to 4 week old human embryo), then transfer into liver. At the end of the pregnancy stage, erythrocytes are formed in the bone marrow (6). The life span of human red blood cells is about days. They are relative simple since they don t have nuclei (7) and flexible biconcave discus with diameter about 8µM. Therefore, they enable to enter the capillaries easily. Afterwards, their membrane becomes more rigid and then they are eliminated from the circulation by the macrophage. The main function of erythrocytes is the gases exchange in the body, they transfer the oxygen from the lung into the tissues and take the generated carbon dioxide, which result from the metabolic process (5). Renal erythropoietin is an important hormone, which plays an important role in the blood formation via stimulation the stem cells in bone marrow. In case of decreasing of the oxygen level (hypoxia), the kidneys sense and secret hormone erythropoietin (EPO) into the blood circulation, which induce the hematopoietic growth factor to produce the erythrocytes into the circulation to correct the tissues hypoxia (8). 3
4 Fig(1). Role of the erythropoietin in the blood formation (8). 2. Membrane of red blood cell The human membrane of red blood cells consists of lipid, protein and carbohydrate. Phospholipid and cholesterol are the main lipid in the cell membrane. The lipids are asymmetrically distributed through the biological cell membrane, where the phosphatidylcholin (PC) and the sphengomyelin (SM) are located predominantly in the outer layer, whereas phosphtidylethanolamin(pe), phosphtidylinositols(pi), and phoshatidylserine(ps) are found mostly in the inner leaflet of bilayer (4). The membrane proteins composed of an external hydrophobic portion attached with carbohydrate, an internal hydrophilic portion. Under the lipids bilayers found several of proteins spectrin, ankyrin and actin, these proteins forms filamentous network know as cytoskeleton. The cytoskeleton interact with the lipids bilayers 4
5 and the integral proteins to maintenance the membrane integrity, also it play an important role in the red blood cells shape and their flexibility (1). Fig(2). Structure of the proteins cytoskeleton (1). The membrane phospholipids are regulated by three different proteins, flippase, floppase and scramblase. As shown in the figure(3), the aminophospholipide translocase (flippase)is responsible for the transferring phosphatidylethanolamine (PE) and phpsphatidylserine (PS) from the outer to the inner leaflet against their concentration gradient, whereas the protein floppase flop the phospholipids from one side of bilayer to the other, especially sphingomyelin(sm) and phoshatidylcholine(pc) from the inner leaflet to the outer surface. Scramlase is responsible for the translocation phospholipids between two layers of cell membrane (flip-flop) (4). 5
6 Fig(3). Phospholipids bilayer of cell membrane (4). 3. Exposure of phosphatidylserine and intracellular ca 2+ In the normal conditions the phosphatidylserine (PS) located in the inner leaflet membrane red blood cells, the exposure of phosphatidylserine(ps) on the outer surface of erythrocytes considers as a marker for eryptosis, while in the nucleated cells serve as a signal for apoptosis. This signal recognized by macrophage to remove these cells from circulation blood, the eryptosis cell characterized by membrane blebbing, phosphatidylserine(ps) exposure and vesicle formation (2). As shown in the figure (4), the activation of the platelets under certain condition leads to release prostaglandin E2 and lysophosphtidic acid (LPA). These substances consider as mediators, which activate a nonselective voltage dependent cation (NSVDC) channel leading to an influx of extracellular Ca 2+. The increase of intracellular Ca 2+ activates the Gardios channel and scramblase, whereas aminophosphlipid translocase (flippase) inhibited the activation of 6
7 Gardos channel leads to an efflux of intracellular KCL and subsequently lead to shrinking the cell (7). The exposure of phosphatidylserine on the outer leaflet lead to adhesion of the cell into the endothelium in some diseases like malaria, diabetes, thalassemia and sickle cell anemia (2). Fig(4). Signaling cascade for PS exposure in red blood cells (7). Furthermore, the activation of the erythrocytes by various activators leads to elevation in the intracellular calcium content. This elevation differs according to the kind of the activator and rising the intracellular calcium which activates the calcium pump. As shown in the figure(5) the treatment of the RBCs with lysophosphatidic acid(lpa) lead to direct increasing in the intracellular Ca 2+ and reached to 80%, in comparison with the Ca 2+ ionophore A23187 the elevation reached to 99.2%. Whereas, the activation of the cells by phorbol-12 myristate-13 acetate PMA the increasing in the intracellular Ca 2+ is less than the 7
8 lysophosphatidic acid LPA and Ca 2+ ionophore A23187 with percentage about 40% (2). Fig(5). Intracellular Ca 2+ of RBCs activate with 2.5LPA,2 A23187,6 PMA (2). The annexin V used to detect the exposure of phosphatidylserine since its specifically binding to the exposed phosphatidylserine. The erythrocytes are activated by lysophosphatidic acid (LPA), Ca 2+ ionophore A23187 or phorbol-12 myristate-13 acetate(pma) in the presence of 2mM of extracellular Ca2+ which leads to phoshatidylserine exposure in the outer leaflet of RBCs membrane with different values. As shown in the fig (6) the activation of RBCs by LPA, A23187 and PMA in presence and in the absence of extracellular Ca 2+. In case of the presence of Ca 2+ the phoshatidylserine exposure about 35% which were activated by LPA and about 20% with A In addition, the treatment with PMA showed a significant increase of phoshatidylserine exposure (80%) and higher than the stimulation by LPA or A In the absence of extracellular Ca 2+ the results were different, there were no phoshatidylserine exposure during the treatment of RBCs by the activators LPA and A In contrast to that, the activation by PMA there 8
9 was a significant increase in phoshatidylserine exposure in the outer leaflet of RBCs membrane about 50%, but this was lower than in the present of 2+ (2). extracellular a Ca Fig (6) phoshatidylserine exposure in RBCs in the presence and absence extracellular Ca 2+ (2).. 9
10 References 1.J. E. Smith Erythrocyte Membrane: Structure, Function, and Pathophysiology Vet Pathol : Nguyen D,B,., Wagner-Britz, L, Maia S, Steffen P, Wagner C, Kaestner L., 4 and Bernhardt I Regulation of Phosphatidylserine Exposure in Red Blood Cells 3.Kaestner, L., Steffen, P, Nguyen, D.B., Wang, J., Wagner-Britz, L., Jung, A., Wagner. C., Bernhardt, I Lysophosphatidic acid induced red blood cell aggregation in vitro. Bioelectrochemistry 87 (2011), R. F. A. Zwaal*, P. Comfurius and E. M. Bevers Surface exposure of phosphatidylserine in pathological cells 5.S. Peter Klinken Red blood cells 6. K. M. MORITZ,1 GAIK BEE LIM,2 AND E. M. WINTOUR1 Developmental regulation of erythropoietin and erythropoiesis 7. Nguyen, D.B Phosphatidylserine exposure in red blood cells: A suggestion for the active role of red blood cells in blood clot formation. Dissertation, Universität des Saarlandes, Jerry L. Spivak THE ANAEMIA OF CANCER DEATH BY A THOUSAND CUTS 2005 ( ) 10
Cardiovascular System. Blood Components
Cardiovascular System Blood Components 1 Components of Blood Formed elements: erythrocytes, leukocytes, platelets Plasma: water, proteins, other solutes The components of blood can be divided into two
More informationBlood Sticky, opaque fluid with a metallic taste (Fe 2+ ) Varies from scarlet (P O2 = 100) to dark red (P O2 = 40) ph is between 7.35 and 7.45 Average volume in an adult is 5 L (7% of body weight) 2 L
More informationBLOOD-Chp. Chp.. 6 What are the functions of blood? What is the composition of blood? 3 major types of plasma proteins
6.1 Blood: An overview BLOOD-Chp Chp.. 6 What are the functions of blood? Transportation: oxygen, nutrients, wastes, carbon dioxide and hormones Defense: against invasion by pathogens Regulatory functions:
More informationBIOLOGICAL MEMBRANES: FUNCTIONS, STRUCTURES & TRANSPORT
BIOLOGICAL MEMBRANES: FUNCTIONS, STRUCTURES & TRANSPORT UNIVERSITY OF PNG SCHOOL OF MEDICINE AND HEALTH SCIENCES DISCIPLINE OF BIOCHEMISTRY AND MOLECULAR BIOLOGY BMLS II / B Pharm II / BDS II VJ Temple
More informationUnit 2: Cells, Membranes and Signaling CELL MEMBRANE. Chapter 5 Hillis Textbook
Unit 2: Cells, Membranes and Signaling CELL MEMBRANE Chapter 5 Hillis Textbook HOW DOES THE LAB RELATE TO THE NEXT CHAPTER? SURFACE AREA: the entire outer covering of a cell that enables materials pass.
More informationThe Lipid Bilayer Is a Two-Dimensional Fluid
The Lipid Bilayer Is a Two-Dimensional Fluid The aqueous environment inside and outside a cell prevents membrane lipids from escaping from bilayer, but nothing stops these molecules from moving about and
More informationFunctions of Blood. Collects O 2 from lungs, nutrients from digestive tract, and waste products from tissues Helps maintain homeostasis
Blood Objectives Describe the functions of blood Describe blood plasma Explain the functions of red blood cells, white blood cells, and platelets Summarize the process of blood clotting What is Blood?
More informationKEY CHAPTER 14: BLOOD OBJECTIVES. 1. Describe blood according to its tissue type and major functions.
KEY CHAPTER 14: BLOOD OBJECTIVES 1. Describe blood according to its tissue type and major functions. TISSUE TYPE? MAJOR FUNCTIONS connective Transport Maintenance of body temperature 2. Define the term
More informationBSC 2010 - Exam I Lectures and Text Pages. The Plasma Membrane Structure and Function. Phospholipids. I. Intro to Biology (2-29) II.
BSC 2010 - Exam I Lectures and Text Pages I. Intro to Biology (2-29) II. Chemistry of Life Chemistry review (30-46) Water (47-57) Carbon (58-67) Macromolecules (68-91) III. Cells and Membranes Cell structure
More informationA.L. Wafa a sameer 2014 Circulatory system / Physiology. Physiology of blood
Red Blood Cells (Erythrocytes) Physiology of blood E rythrocytes : are the most abundant cells of the blood and are necessary for the delivery of oxygen to the tissues. The major function of red blood
More informationFIGURE 2.18. A. The phosphate end of the molecule is polar (charged) and hydrophilic (attracted to water).
PLASMA MEMBRANE 1. The plasma membrane is the outermost part of a cell. 2. The main component of the plasma membrane is phospholipids. FIGURE 2.18 A. The phosphate end of the molecule is polar (charged)
More informationCell Membrane Structure (and How to Get Through One)
Cell Membrane Structure (and How to Get Through One) A cell s membrane is a wall of sorts that defines the boundaries of a cell. The membrane provides protection and structure for the cell and acts as
More informationCell Membranes Part 1: Review of Membrane Structure and Changes with Aging By Dan Carter, ND
Introduction Does cell membrane physiology degrade over time? Can the physiologic function of cell membranes be improved? If cell membrane functionality can be improved, is there clinical benefit to patients?
More information1.1.2. thebiotutor. AS Biology OCR. Unit F211: Cells, Exchange & Transport. Module 1.2 Cell Membranes. Notes & Questions.
thebiotutor AS Biology OCR Unit F211: Cells, Exchange & Transport Module 1.2 Cell Membranes Notes & Questions Andy Todd 1 Outline the roles of membranes within cells and at the surface of cells. The main
More information4. Biology of the Cell
4. Biology of the Cell Our primary focus in this chapter will be the plasma membrane and movement of materials across the plasma membrane. You should already be familiar with the basic structures and roles
More informationSix major functions of membrane proteins: Transport Enzymatic activity
CH 7 Membranes Cellular Membranes Phospholipids are the most abundant lipid in the plasma membrane. Phospholipids are amphipathic molecules, containing hydrophobic and hydrophilic regions. The fluid mosaic
More informationBiological cell membranes
Unit 14: Cell biology. 14 2 Biological cell membranes The cell surface membrane surrounds the cell and acts as a barrier between the cell s contents and the environment. The cell membrane has multiple
More informationchemicals > transported from outside to in > waste products created > they need to be removed
1 Transport systems chemicals > transported from outside to in > waste products created > they need to be removed Simple organisms Diffusion the free movement of particles in a liquid or a gas down a concentration
More informationMembrane Structure and Function
Membrane Structure and Function -plasma membrane acts as a barrier between cells and the surrounding. -plasma membrane is selective permeable -consist of lipids, proteins and carbohydrates -major lipids
More informationCh. 8 - The Cell Membrane
Ch. 8 - The Cell Membrane 2007-2008 Phospholipids Phosphate head hydrophilic Fatty acid tails hydrophobic Arranged as a bilayer Phosphate attracted to water Fatty acid repelled by water Aaaah, one of those
More informationKeystone Review Practice Test Module A Cells and Cell Processes. 1. Which characteristic is shared by all prokaryotes and eukaryotes?
Keystone Review Practice Test Module A Cells and Cell Processes 1. Which characteristic is shared by all prokaryotes and eukaryotes? a. Ability to store hereditary information b. Use of organelles to control
More informationHuman Anatomy & Physiology I with Dr. Hubley. Practice Exam 1
Human Anatomy & Physiology I with Dr. Hubley Practice Exam 1 1. Which definition is the best definition of the term gross anatomy? a. The study of cells. b. The study of tissues. c. The study of structures
More informationThibodeau: Anatomy and Physiology, 5/e. Chapter 17: Blood
Thibodeau: Anatomy and Physiology, 5/e Chapter 17: Blood This chapter begins a new unit. In this unit, the first four chapters deal with transportation one of the body's vital functions. It is important
More informationBlood. Blood. Blood Composition. Blood Composition. Fractionation & Hemopoesis
Blood Blood Chapter 19 Blood is a specialized fluid connective tissue that contains cells suspended in a fluid matrix Functions of blood include: Transport of dissolved gases, nutrients, hormones and metabolic
More informationCyclooxygenase and NSAIDs
Cyclooxygenase and NSAIDs Cyclooxygenase An enzyme responsible for the production of prostaglandins Two forms, COX1 and COX2 Contains two separate active sites for prostaglandin synthase One side contains
More informationHomeostasis and Transport Module A Anchor 4
Homeostasis and Transport Module A Anchor 4 Key Concepts: - Buffers play an important role in maintaining homeostasis in organisms. - To maintain homeostasis, unicellular organisms grow, respond to the
More information2161-1 - Page 1. Name: 1) Choose the disease that is most closely related to the given phrase. Questions 10 and 11 refer to the following:
Name: 2161-1 - Page 1 1) Choose the disease that is most closely related to the given phrase. a disease of the bone marrow characterized by uncontrolled production of white blood cells A) meningitis B)
More informationCirculatory System Review
Circulatory System Review 1. Draw a table to describe the similarities and differences between arteries and veins? Anatomy Direction of blood flow: Oxygen concentration: Arteries Thick, elastic smooth
More informationExercise 9: Blood. Readings: Silverthorn 5 th ed, 547 558, 804 805; 6 th ed, 545 557, 825 826.
Exercise 9: Blood Readings: Silverthorn 5 th ed, 547 558, 804 805; 6 th ed, 545 557, 825 826. Blood Typing The membranes of human red blood cells (RBCs) contain a variety of cell surface proteins called
More informationBlood. Functions of Blood. Components of Blood. Transporting. Distributing body heat. A type of connective tissue. Formed elements.
Blood Functions of Blood Transporting nutrients respiratory gases waste products Distributing body heat Components of Blood A type of connective tissue Formed elements Living blood cells Plasma Nonliving
More informationUNIT 3 : MAINTAINING DYNAMIC EQUILIBRIUM
BIOLOGY - 2201 UNIT 3 : MAINTAINING DYNAMIC EQUILIBRIUM What happens to your body as you run? Breathing, heart rate, temperature, muscle pain, thirsty... Homeotasis Homeostasis is the process of maintaining
More informationPlasma Membrane hydrophilic polar heads
The Parts of the Cell 3 main parts in ALL cells: plasma membrane, cytoplasm, genetic material this is about the parts of a generic eukaryotic cell Plasma Membrane -is a fluid mosaic model membrane is fluid
More informationHow To Understand The Chemistry Of Organic Molecules
CHAPTER 3 THE CHEMISTRY OF ORGANIC MOLECULES 3.1 Organic Molecules The chemistry of carbon accounts for the diversity of organic molecules found in living things. Carbon has six electrons, four of which
More informationVisual Acuity. Hearing. Height and Weight. Blood Pressure MEASURED VALUE
TEST ITEM DESCRIPTION STANDARD LEVEL Standard level varies among different examination methods. Please check with your medical facility about normal level. MEASURED VALUE Visual Acuity You look at rings
More informationCELL MEMBRANES, TRANSPORT, and COMMUNICATION. Teacher Packet
AP * BIOLOGY CELL MEMBRANES, TRANSPORT, and COMMUNICATION Teacher Packet AP* is a trademark of the College Entrance Examination Board. The College Entrance Examination Board was not involved in the production
More informationActions of Hormones on Target Cells Page 1. Actions of Hormones on Target Cells Page 2. Goals/ What You Need to Know Goals What You Need to Know
Actions of Hormones on Target Cells Graphics are used with permission of: Pearson Education Inc., publishing as Benjamin Cummings (http://www.aw-bc.com) Page 1. Actions of Hormones on Target Cells Hormones
More information3. The Circulatory System
3. The Circulatory System A. Introduction B. Blood 1. Circulatory system transports water, electrolytes, hormones, enzymes, antibodies, cell, gases and nutrients to all cells and carries away metabolic
More informationCHAPTER 14: CARDIOVASCULAR SYSTEM: BLOOD. 1. Describe blood according to its tissue type and major functions.
OBJECTIVES: 1. Describe blood according to its tissue type and major functions. 2. Define the term hematology. 3. Name the average volume of blood in a human. 4. Name the two major components of blood
More informationWhat Does My Bone Marrow Do?
What Does My Bone Marrow Do? the myelodysplastic syndromes foundation, inc. Illustrations by Kirk Moldoff Published by The Myelodysplastic Syndromes Foundation, Inc. First Edition, 2009. 2012. Table of
More informationMammalian Physiology. Cellular Membranes Membrane Transport UNLV. PHYSIOLOGY, Chapter 1 Berne, Levy, Koeppen, Stanton UNIVERSITY OF NEVADA LAS VEGAS
Mammalian Physiology Cellular Membranes Membrane Transport UNLV 1 UNIVERSITY OF NEVADA LAS VEGAS PHYSIOLOGY, Chapter 1 Berne, Levy, Koeppen, Stanton Objectives Describe the structure of the cell membrane
More informationCHAPTER 2: BLOOD CIRCULATION AND TRANSPORT
CHAPTER 2: BLOOD CIRCULATION AND TRANSPORT BLOOD CIRCULATION AND TRANSPORT HUMAN BEING PLANTS Function of heart Wilting Structure of heart Blood vessels: characteristics and functions Transpiration: function
More informationBiotechnology. Srivatsan Kidambi, Ph.D.
Stem Stem Cell Cell Engineering-What, Biology and it Application Why, How?? to Biotechnology Srivatsan Kidambi, Ph.D. Assistant Professor Department of Chemical & Biomolecular Engineering University of
More informationRAD 223. Radiography physiology. Lecture Notes. First lecture: Cell and Tissue
RAD 223 Radiography physiology Lecture Notes First lecture: Cell and Tissue Physiology: the word physiology derived from a Greek word for study of nature. It is the study of how the body and its part work
More informationLaboratory 12 Blood Cells
Laboratory 12 Blood Cells Objectives: Identify microscopically each of the following: erythrocytes (red blood cells or RBCs), the five types of leukocytes (white blood cells or WBCs), and thrombocytes
More informationCHAPTER 5.1 5.2: Plasma Membrane Structure
CHAPTER 5.1 5.2: Plasma Membrane Structure 1. Describe the structure of a phospholipid molecule. Be sure to describe their behavior in relationship to water. 2. What happens when a collection of phospholipids
More informationIB104 - Lecture 9 - Membranes
There have been many magnificent boats built to try to reach 50 knots. This was the creation of an Australian team that held the record for more than a decade, from 1993 till 2005, at 46.5 knots with their
More informationCompartmentalization of the Cell. Objectives. Recommended Reading. Professor Alfred Cuschieri. Department of Anatomy University of Malta
Compartmentalization of the Cell Professor Alfred Cuschieri Department of Anatomy University of Malta Objectives By the end of this session the student should be able to: 1. Identify the different organelles
More information37 2 Blood and the Lymphatic System Slide 1 of 34
1 of 34 Blood is a connective tissue that contains both dissolved substances and specialized cells. 2 of 34 The functions of blood include: collecting oxygen from the lungs, nutrients from the digestive
More informationChapter 3. Cellular Structure and Function Worksheets. 39 www.ck12.org
Chapter 3 Cellular Structure and Function Worksheets (Opening image copyright by Sebastian Kaulitzki, 2010. Used under license from Shutterstock.com.) Lesson 3.1: Introduction to Cells Lesson 3.2: Cell
More informationAnatomy and Physiology Placement Exam 2 Practice with Answers at End!
Anatomy and Physiology Placement Exam 2 Practice with Answers at End! General Chemical Principles 1. bonds are characterized by the sharing of electrons between the participating atoms. a. hydrogen b.
More informationCells, tissues and organs
Chapter 8: Cells, tissues and organs Cells: building blocks of life Living things are made of cells. Many of the chemical reactions that keep organisms alive (metabolic functions) take place in cells.
More informationD. Vitamin D. 1. Two main forms; vitamin D2 and D3
D. Vitamin D. Two main forms; vitamin D2 and D3 H H D3 - Cholecalciferol D2 - Ergocalciferol Technically, vitamin D is not a vitamin. It is the name given to a group of fat-soluble prohormones (substances
More informationINTRODUCTION TO HORMONES
INTRODUCTION TO HORMONES UNIVERSITY OF PNG SCHOOL OF MEDICINE AND HEALTH SCIENCES DISCIPLINE OF BIOCHEMISTRY & MOLECULAR BIOLOGY PBL MBBS II SEMINAR VJ Temple What are hormones? Cells in multi-cellular
More informationCell Membrane & Tonicity Worksheet
NAME ANSWER KEY DATE PERIOD Cell Membrane & Tonicity Worksheet Composition of the Cell Membrane & Functions The cell membrane is also called the PLASMA membrane and is made of a phospholipid BI-LAYER.
More informationDate: Student Name: Teacher Name: Jared George. Score: 1) A cell with 1% solute concentration is placed in a beaker with a 5% solute concentration.
Biology Keystone (PA Core) Quiz Homeostasis and Transport - (BIO.A.4.1.1 ) Plasma Membrane, (BIO.A.4.1.2 ) Transport Mechanisms, (BIO.A.4.1.3 ) Transport Facilitation Student Name: Teacher Name: Jared
More informationChapter 16: Innate Immunity
Chapter 16: Innate Immunity 1. Overview of Innate Immunity 2. Inflammation & Phagocytosis 3. Antimicrobial Substances 1. Overview of Innate Immunity The Body s Defenses The body has 2 types of defense
More informationGround substance is the component of connective tissue between the cells and the fibers
Connective Tissues Directions: Insert and install your Interactions: Foundations CD. a. Click the "Contents" button. b. Open the Tissue Level of Organization file. c. Click on Anatomy Overviews. d. Work
More informationAbsorption of Drugs. Transport of a drug from the GI tract
Absorption of Drugs Absorption is the transfer of a drug from its site of administration to the bloodstream. The rate and efficiency of absorption depend on the route of administration. For IV delivery,
More informationUses of Flow Cytometry
Uses of Flow Cytometry 1. Multicolour analysis... 2 2. Cell Cycle and Proliferation... 3 a. Analysis of Cellular DNA Content... 4 b. Cell Proliferation Assays... 5 3. Immunology... 6 4. Apoptosis... 7
More informationCell membranes and transport. Learning Objective:
Cell membranes and transport Content Fluid mosaic model of membrane structure Movement of substances into and out of cells Learning Objective: a. Describe and explain the fluid mosaic model of membrane
More informationChapter 8. Movement across the Cell Membrane. AP Biology
Chapter 8. Movement across the Cell Membrane More than just a barrier Expanding our view of cell membrane beyond just a phospholipid bilayer barrier phospholipids plus Fluid Mosaic Model In 1972, S.J.
More informationQuick Hit Activity Using UIL Science Contests For Formative and Summative Assessments of Pre-AP and AP Biology Students
Quick Hit Activity Using UIL Science Contests For Formative and Summative Assessments of Pre-AP and AP Biology Students Activity Title: Quick Hit Goal of Activity: To perform formative and summative assessments
More informationCell Membrane Coloring Worksheet
Cell Membrane Coloring Worksheet Composition of the Cell Membrane & Functions The cell membrane is also called the plasma membrane and is made of a phospholipid bilayer. The phospholipids have a hydrophilic
More informationCell Transport and Plasma Membrane Structure
Cell Transport and Plasma Membrane Structure POGIL Guided Inquiry Learning Targets Explain the importance of the plasma membrane. Compare and contrast different types of passive transport. Explain how
More informationPART I: Neurons and the Nerve Impulse
PART I: Neurons and the Nerve Impulse Identify each of the labeled structures of the neuron below. A. B. C. D. E. F. G. Identify each of the labeled structures of the neuron below. A. dendrites B. nucleus
More informationStimulated Nonspecific Transport of Phospholipids Results in Elevated External Appearance of Phosphatidylserine in ras-transformed Fibroblasts
Archives of Biochemistry and Biophysics Vol. 381, No. 2, September 15, pp. 295 301, 2000 doi:10.1006/abbi.2000.1986, available online at http://www.idealibrary.com on Stimulated Nonspecific Transport of
More informationCELL MEMBRANE & CELL TRANSPORT (PASSIVE and ACTIVE) Webquest
Name: Period: CELL MEMBRANE & CELL TRANSPORT (PASSIVE and ACTIVE) Webquest PART I: CELL MEMBRANES WEBSITE #1: http://www.wisc-online.com/objects/index_tj.asp?objid=ap1101 1. What is the BASIC UNIT of LIFE?
More informationBiological Membranes. Impermeable lipid bilayer membrane. Protein Channels and Pores
Biological Membranes Impermeable lipid bilayer membrane Protein Channels and Pores 1 Biological Membranes Are Barriers for Ions and Large Polar Molecules The Cell. A Molecular Approach. G.M. Cooper, R.E.
More informationChapter 16: Circulation
Section 1 (The Body s Transport System) Chapter 16: Circulation 7 th Grade Cardiovascular system (the circulatory system) includes the heart, blood vessels, and blood carries needed substances to the cells
More informationHow To Expand Hematopoietic Stem Cells
Purification and Expansion of Hematopoietic Stem Cells Based on Proteins Expressed by a Novel Stromal Cell Population Our bodies are constantly killing old, nonfunctional, and unneeded cells and making
More informationReproductive System & Development: Practice Questions #1
Reproductive System & Development: Practice Questions #1 1. Which two glands in the diagram produce gametes? A. glands A and B B. glands B and E C. glands C and F D. glands E and F 2. Base your answer
More informationFunctions of Blood System. Blood Cells
Functions of Blood System Transport: to and from tissue cells Nutrients to cells: amino acids, glucose, vitamins, minerals, lipids (as lipoproteins). Oxygen: by red blood corpuscles (oxyhaemoglobin - 4
More informationThe diagram below summarizes the effects of the compounds that cells use to regulate their own metabolism.
Regulation of carbohydrate metabolism Intracellular metabolic regulators Each of the control point steps in the carbohydrate metabolic pathways in effect regulates itself by responding to molecules that
More informationModes of Membrane Transport
Modes of Membrane Transport Transmembrane Transport movement of small substances through a cellular membrane (plasma, ER, mitochondrial..) ions, fatty acids, H 2 O, monosaccharides, steroids, amino acids
More informationguides BIOLOGY OF AGING STEM CELLS An introduction to aging science brought to you by the American Federation for Aging Research
infoaging guides BIOLOGY OF AGING STEM CELLS An introduction to aging science brought to you by the American Federation for Aging Research WHAT ARE STEM CELLS? Stem cells are cells that, in cell cultures
More informationBio 20 Chapter 11 Workbook Blood and the Immune System Ms. Nyboer
Bio 20 Chapter 11 Workbook Blood and the Immune System Ms. Nyboer Name: Part A: Components of Blood 1. List the 3 plasma proteins and describe the function of each Albumins osmotic balance Globulins antibodies,
More information10. T and B cells are types of a. endocrine cells. c. lymphocytes. b. platelets. d. complement cells.
Virus and Immune System Review Directions: Write your answers on a separate piece of paper. 1. Why does a cut in the skin threaten the body s nonspecific defenses against disease? a. If a cut bleeds, disease-fighting
More informationREVIEW for BIOLOGY UNIT TEST
REVIEW for BIOLOGY UNIT TEST NOTE: The Unit Test will cover everything we have learned in the Biology Unit, starting from cell structures, cell division, various organ systems, disorders, organ donation,
More informationIons cannot cross membranes. Ions move through pores
Ions cannot cross membranes Membranes are lipid bilayers Nonpolar tails Polar head Fig 3-1 Because of the charged nature of ions, they cannot cross a lipid bilayer. The ion and its cloud of polarized water
More informationTHE LIVING CELL. Cells also have variety of shapes. Plant cells are often rectangular or polygonal, while egg cells are usually spherical.
THE LIVING CELL A Tour of the cell The cell is the smallest and the basic unit of structure of all organisms. There are two main types or categories of cells: prokaryotic cells and eukaryotic cells. Prokaryotic
More informationQuestions on The Nervous System and Gas Exchange
Name: Questions on The Nervous System and Gas Exchange Directions: The following questions are taken from previous IB Final Papers on Topics 6.4 (Gas Exchange) and 6.5 (Nerves, hormones and homeostasis).
More informationLAB: Blood Exploration
Name: Period: Date: LAB: Blood Exploration Introduction A liquid called plasma makes up about half (55%) of the content of blood. Plasma contains proteins that help blood to clot, transport substances
More informationHydroxyurea Treatment for Sickle Cell Disease
Hydroxyurea Treatment for Sickle Cell Disease Before hydroxyurea After hydroxyurea Hydroxyurea Treatment for Sickle Cell Disease 1 This document is not intended to take the place of the care and attention
More information2006 7.012 Problem Set 6 KEY
2006 7.012 Problem Set 6 KEY ** Due before 5 PM on WEDNESDAY, November 22, 2006. ** Turn answers in to the box outside of 68-120. PLEASE WRITE YOUR ANSWERS ON THIS PRINTOUT. 1. You create an artificial
More information12.1: The Function of Circulation page 478
12.1: The Function of Circulation page 478 Key Terms: Circulatory system, heart, blood vessel, blood, open circulatory system, closed circulatory system, pulmonary artery, pulmonary vein, aorta, atrioventricular
More information1 The diagram shows blood as seen under a microscope. Which identifies parts P, Q, R and S of the blood?
1 1 The diagram shows blood as seen under a microscope. Which identifies parts P, Q, R and S of the blood? 2 The plan shows the blood system of a mammal. What does the part labelled X represent? A heart
More informationBIO 137: CHAPTER 1 OBJECTIVES
BIO 137: CHAPTER 1 OBJECTIVES 1. Define the terms anatomy and physiology, and explain their relationship using an example of a human structure with its corresponding function. A. ANATOMY = the study of
More informationWhite Blood Cells (WBCs) or Leukocytes
Lec.5 Z.H.Al-Zubaydi Medical Physiology White Blood Cells (WBCs) or Leukocytes Although leukocytes are far less numerous than red blood cells, they are important to body defense against disease. On average,
More informationThe Immune System. 2 Types of Defense Mechanisms. Lines of Defense. Line of Defense. Lines of Defense
The Immune System 2 Types of Defense Mechanisms Immune System the system that fights infection by producing cells to inactivate foreign substances to avoid infection and disease. Immunity the body s ability
More informationVertebrate Body Organization
Vertebrate Body Organization Digestive tube suspended in coelom from mouth to anus Body supported by internal skeleton of jointed bones Vertebrae and Cranium protects nervous system Diaphragm divides coelom
More informationPaper 1 Answer all questions. Each question is followed by four options, A, B, C and D. For each question, choose one answer only
hapter 19 lood irculation and Transport Paper 1 nswer all questions. Each question is followed by four options,,, and. For each question, choose one answer only 1. Type of blood cell P Q R Function Protects
More informationChapter 18. Blood Types
Chapter 18 Blood Types Blood Types blood types and transfusion compatibility are a matter of interactions between plasma proteins and erythrocytes Karl Landsteiner discovered blood types A, B and O in
More informationCell Biology - Part 2 Membranes
Cell Biology - Part 2 Membranes The organization of cells is made possible by membranes. Membranes isolate, partition, and compartmentalize cells. 1 Membranes isolate the inside of the cell from the outside
More informationCells and Their Housekeeping Functions Cell Membrane & Membrane Potential
Cells and Their Housekeeping Functions Cell Membrane & Membrane Potential Shu-Ping Lin, Ph.D. Institute of Biomedical Engineering E-mail: splin@dragon.nchu.edu.tw Website: http://web.nchu.edu.tw/pweb/users/splin/
More informationSupport Program for Improving Graduate School Education Advanced Education Program for Integrated Clinical, Basic and Social Medicine
Support Program for Improving Graduate School Education Advanced Education Program for Integrated Clinical, Basic and Social Medicine January 27, 2009 Dear Professors (representative) of departments, Subject:
More informationBlood Questions. 8. A reduced ability to produce thrombin would cause the time required for blood clot formation to:
Answer the first 40 items with: a. Increase b. Decrease c. Stay the same 1. An increase in plasma levels of erythropoietin will cause blood viscosity to: 2. The activation of plasminogen will cause the
More informationwhole blood consists of two main elements: the formed elements
bloodc components TERI JUNGE, CST/CFA whole blood consists of two main elements: the formed elements and the liquid element. The formed elements are cell fragments and cells, known as corpuscles, which
More informationAn Overview of Cells and Cell Research
An Overview of Cells and Cell Research 1 An Overview of Cells and Cell Research Chapter Outline Model Species and Cell types Cell components Tools of Cell Biology Model Species E. Coli: simplest organism
More informationThe Molecules of Cells
The Molecules of Cells I. Introduction A. Most of the world s population cannot digest milk-based foods. 1. These people are lactose intolerant because they lack the enzyme lactase. 2. This illustrates
More informationLecture 4 Cell Membranes & Organelles
Lecture 4 Cell Membranes & Organelles Structure of Animal Cells The Phospholipid Structure Phospholipid structure Encases all living cells Its basic structure is represented by the fluidmosaic model Phospholipid
More information