Søgeprotokol for Nationale Kliniske Retningslinjer

Transcription

1 Søgeprotokol for Nationale Kliniske Retningslinjer Projekttitel/aspekt NKR for urininkontinens hos kvinder - sekundær litteratur Fagkonsulent / Jimmi Elers / Christina Debes Helm projektleder Søgespecialist Jette Frost Jepsen Senest opdateret 12. juni 2015 Baggrund PICO 1: Bør kvinder med urininkontinens tilbydes superviseret bækkenbundstræning? PICO 2: Bør kvinder med urgency urininkontinens tilbydes blæretræning? PICO 3: Bør kvinder med urininkontinens tilbydes behandling med vaginalt hjælpemiddel? PICO 4: Bør kvinder med urininkontinens og påvirkede mentale funktioner tilbydes aktiv urininkontinensudredning og behandling? PICO 5: Bør kvinder med svær overvægt og stress urininkontinens tilbydes superviseret vægttabsprogram? PICO 6: Bør kvinder med stress urininkontinens tilbydes bækkenbundstræning frem for operation med midturethral slynge? PICO 7: Bør kvinder med svær overvægt og stress urininkontinens tilbydes primær operation med midturethral slynge? PICO 8: Bør kvinder med stress urininkontinens tilbydes MUS-RT frem for MUS-TO? PICO 9: Bør postmenopausale kvinder med urgency urininkontinens behandles med vaginal østrogentilskud som add-on til antimuskarinergika/beta-3 agonist? PICO 10: Bør kvinder med urgency urininkontinens behandles med beta3-agonist frem for antimuskarinergika? Søgetermer Inklusions- og eksklusionskriterier Se søgestrategierne under de enkelte PICOs Sprog: Engelsk, dansk, norsk og svensk År: Se de enkelte PICOs Population: Kvinder med urininkontinens Publikationstyper: Sekundær litteratur / Systematic reviews, metaanalyser 1

2 Informationskilder Database Interface Dato for søgning The Cochrane library Internettet Medline OVID EMBASE OVID CINAHL EBSCO PEDro Internettet Note Søgetermer og inklusions- og eksklusionskriterier er tilpasset de enkelte databaser. Dubletter er så vidt muligt frasorteret ved hjælp af RefWorks. De fundne referencer overføres til Covidence (referenceværktøj) Fuldtekster præsenteres i Covidence i pdf-format Søgestrategi for hver enkelt database præsenteres hvis muligt vises det eksplicit hvor mange referencer den enkelte søgestreng genererer 2

3 Søgestrategi PICO 1 (324 poster efter dubletsøgning) Medline 1 exp Exercise Therapy/ exp Muscle Contraction/ Muscle Strength/ exp Physical Therapy Modalities/ (pelvic floor muscle training or PFMT).mp (pelvic floor adj3 (train* or exercis*)).mp (pelvic muscle adj3 (train* or exercis*)).mp (physical therap* or physioterap*).mp (kegel or kegels).mp or/ exp Urinary Incontinence/ Urinary Incontinence, Urge/ Urinary Incontinence, Stress/ ((stress or urge* or mix* or urin* or bladder) adj incontinence).mp incontinence, urine.mp incontinence, urinary.mp incontinentia urinae.mp urinary leak*.mp urine leak*.mp Urinary Bladder, Overactive/ overactive bladder.mp OAB.mp or/ not prosta*.mp and limit 25 to (meta analysis or systematic reviews) meta-analysis/ or meta-analysis as topic/ (meta analys* or metaanalys* or systematic review*).mp or and or limit 31 to (yr="2005 -Current" and (danish or english or norwegian or swedish)) 130 Embase 1 pelvic floor muscle training/ exp kinesiotherapy/ exp muscle contraction/ muscle strength/ exp physiotherapy/ (pelvic floor muscle training or PFMT).mp

4 7 (pelvic floor adj3 (train* or excercis*)).mp (pelvic muscle adj3 (train* or exercis*)).mp exercise therapy.mp (physical therap* or physioterap*).mp (kegel or kegels).mp or/ exp urine incontinence/ urge incontinence/ stress incontinence/ ((stress or urge* or mix* or urin* or bladder) adj incontinence).mp incontinence, urine.mp incontinence, urinary.mp incontinentia urinae.mp urinary leak*.mp urine leak*.mp overactive bladder/ overactive bladder.mp OAB.mp or/ not prosta*.mp and limit 27 to (meta analysis or "systematic review") meta-analysis/ or meta-analysis as topic/ (meta analys* or metaanalys* or systematic review*).mp or and or limit 33 to ((danish or english or norwegian or swedish) and yr="2005 -Current") 179 Cinahl S34 S27 OR S32 Limiters - Published Date: ; Language: Danish, English, 66 Norwegian, Swedish S33 S27 OR S32 83 S32 S26 AND S31 67 S31 S28 OR S29 OR S30 48,059 S30 meta analys* or metaanalys* or systematic review* 48,059 S29 (MH "Meta Analysis") 15,996 S28 (MH "Systematic Review") 22,397 S27 S12 AND S25 61 S26 S12 AND S25 1,320 S25 S24 NOT prosta* 7,837 S24 S13 OR S14 OR S15 OR S16 OR S17 OR S18 OR S19 OR S20 OR S21 OR S22 OR S23 8,334 S23 overactive bladder OR OAB 998 S22 (MH "Overactive Bladder") 735 S21 urine leak* 88 S20 urinary leak* 51 S19 incontinentia urinae 0 4

5 S18 incontinence, urinary 25 S17 incontinence, urine 7 S16 (stress or urge* or mix* or urin* or bladder) incontinence 7,708 S15 (MH "Stress Incontinence") 1,513 S14 (MH "Urge Incontinence") 444 S13 (MH "Urinary Incontinence+") 6,989 S12 S1 OR S2 OR S3 OR S4 OR S5 OR S6 OR S7 OR S8 OR S9 OR S10 OR S11 99,295 S11 exercise therap* 670 S10 kegel or kegels 956 S9 physical therap* or physioterap* 39,586 S8 pelvic floor muscle exercis* 126 S7 pelvic muscle (train* or exercis*) 57 S6 pelvic floor (train* or exercis*) 160 S5 pelvic floor muscle training or PFMT 169 S4 (MH "Physical Therapy+") 73,086 S3 (MH "Muscle Contraction+") 6,824 S2 (MH "Muscle Strength+") OR (MH "Muscle Strengthening+") 21,334 S1 (MH "Kegel Exercises") 930 Cochrane (25 Cochrane Reviews og 38 Other Reviews) #1 MeSH descriptor: [Exercise Therapy] explode all trees 7439 #2 MeSH descriptor: [Muscle Contraction] explode all trees 5916 #3 MeSH descriptor: [Muscle Strength] explode all trees 2703 #4 MeSH descriptor: [Physical Therapy Modalities] explode all trees #5 pelvic floor muscle training or PFMT:ti,ab,kw (Word variations have been searched) 487 #6 pelvic floor (train* or exercis*):ti,ab,kw (Word variations have been searched) 818 #7 pelvic muscle (train* or exercis*):ti,ab,kw (Word variations have been searched) 715 #8 pelvic floor muscle exercis*:ti,ab,kw (Word variations have been searched) 399 #9 physical therap* or physioterap*:ti,ab,kw (Word variations have been searched) #10 kegel or kegels:ti,ab,kw (Word variations have been searched) 46 #11 exercise therap*:ti,ab,kw (Word variations have been searched) #12 #1 or #2 or #3 or #4 or #5 or #6 or #7 or #8 or #9 or #10 or # #13 MeSH descriptor: [Urinary Incontinence] explode all trees 1615 #14 MeSH descriptor: [Urinary Incontinence, Urge] explode all trees 84 #15 MeSH descriptor: [Urinary Incontinence, Stress] explode all trees 696 #16 (stress or urge* or mix* or urin* or bladder) incontinence:ti,ab,kw (Word variations 4168 have been searched) #17 incontinence, urine:ti,ab,kw (Word variations have been searched) 861 #18 incontinence, urinary:ti,ab,kw (Word variations have been searched) 3551 #9 incontinentia urinae:ti,ab,kw (Word variations have been searched) 0 #20 urinary leak*:ti,ab,kw (Word variations have been searched) 489 #21 urine leak*:ti,ab,kw (Word variations have been searched) 267 #22 MeSH descriptor: [Urinary Bladder, Overactive] explode all trees 337 #23 overactive bladder or OAB:ti,ab,kw (Word variations have been searched) 1287 #24 #13 or #14 or #15 or #16 or #17 or #18 or #19 or #20 or #21 or #22 or # #25 #24 not prosta* 4514 #26 #12 and #

6 PEDro (61 hits) Therapy: Strength training OR Fitness training Problem: Incontinence Method: Systematic review Published Since: 2005 PICO 2 (213 poster efter dubletsøgning) Medline 1 Urinary Incontinence, Urge/ Urinary Bladder, Overactive/ Urinary Incontinence/ overactive detrusor function.mp overactive bladder.mp OAB.mp Urge* incontinence.mp Urin* incontinence.mp or/ exp Behavior Therapy/ (bladder adj2 (train* or retrain*)).mp BT.mp (void* adj2 (time* or program* or schedul* or train* or retrain* or prompt* or 662 interval*)).mp. 14 (behavio* adj2 (intervention* or therap* or manage*)).mp or/ and limit 16 to (meta analysis or systematic reviews) meta-analysis/ or meta-analysis as topic/ (meta analys* or metaanalys* or systematic review*).mp or and or (comment or letter or newspaper article or conference).pt not limit 24 to (yr="2005 -Current" and (danish or english or norwegian or swedish)) 91 Embase 1 urge incontinence/ overactive bladder/ urine incontinence/ overactive detrusor function.mp overactive bladder.mp OAB.mp Urge* incontinence.mp

7 8 Urin* incontinence.mp or/ bladder training/ behavior therapy/ (bladder adj2 (train* or retrain*)).mp BT.mp (void* adj2 (time* or program* or schedul* or train* or retrain* or prompt* or 1046 interval*)).mp. 15 (behavio* adj2 (intervention* or therap* or manage*)).mp or/ and meta analysis/ or "systematic review (topic)"/ or "systematic review"/ (meta analys* or metaanalys* or systematic review*).mp or and (comment or letter or newspaper article or conference).pt not limit 23 to ((danish or english or norwegian or swedish) and yr="2005 -Current") 86 Cinahl S24 S21 OR S22 Limiters - Published Date: ; Language: Danish, English, Norwegian, Swedish 56 S23 S21 OR S22 68 Limiters - Publication Type: Meta Analysis, Meta Synthesis, Systematic Review 54 S22 S9 AND S16 S21 S17 AND S20 60 S20 S18 OR S19 48,273 S19 meta analys* or metaanalys* or systematic review* 48,273 S18 (MH "Systematic Review") OR (MH "Meta Analysis") 33,229 S17 S9 AND S16 1,113 S16 S10 OR S11 OR S12 OR S13 OR S14 24,583 S15 behavio* (intervention* or therap* or manage*) 10,068 void* AND ( time* or program* or schedul* or train* or retrain* or prompt* or interval* ) 678 S14 S13 BT 406 S12 bladder (train* or retrain*) 126 S11 (MH "Behavior Modification+") 21,893 S10 (MH "Bowel and Bladder Management+") 1,861 S9 S1 OR S2 OR S3 OR S4 OR S5 OR S6 OR S7 OR S8 8,241 S8 Urin* incontinence 6,754 S7 Urge* incontinence 624 S6 OAB 257 S5 overactive bladder 986 S4 overactive destrusor function 0 S3 (MH "Urinary Incontinence+") 7,003 S2 (MH "Overactive Bladder") 736 7

8 S1 (MH "Urge Incontinence") 444 Cochrane (44 Cochrane Reviews, 9 Other Reviews) #1 MeSH descriptor: [Urinary Incontinence, Urge] explode all trees 85 #2 MeSH descriptor: [Urinary Bladder, Overactive] explode all trees 337 #3 MeSH descriptor: [Urinary Incontinence] explode all trees 1617 #4 Overactive Detrusor Function 56 #5 Overactive bladder 1360 #6 OAB 538 #7 Urge* incontinence 1358 #8 Urin* incontinence 4154 #9 #1 or #2 or #3 or #4 or #5 or #6 or #7 or # #10 MeSH descriptor: [Behavior Therapy] explode all trees #11 bladder (train* or retrain*):ti,ab,kw (Word variations have been searched) 307 #12 BT:ti,ab,kw (Word variations have been searched) 574 #13 void* and (time* or program* or schedul* or train* or retrain* or prompt* or 1040 interval*):ti,ab,kw (Word variations have been searched) #14 behavio* (intervention* or therap* or manage*):ti,ab,kw (Word variations have been searched) #15 #10 or #11 or #12 or #13 or # #16 #9 and # #17 #16 not prosta* 637 PEDro (18 poster) Therapy: Behaviour modification Problem: Incontinence Method: Systematic review Published Since: 2005 PICO 3 (79 poster efter dubletsøgning) Medline 1 exp Urinary Incontinence/ Urinary Incontinence, Urge/ Urinary Incontinence, Stress/ ((stress or urge* or mix* or urin* or bladder) adj incontinence).mp incontinence, urine.mp incontinence, urinary.mp incontinentia urinae.mp. 37 8

9 8 urinary leak*.mp urine leak*.mp Urinary Bladder, Overactive/ overactive bladder.mp OAB.mp or/ not prosta*.mp Pessaries/ Disposable Equipment/ Equipment Design/ (continence adj (guard* or tampon*)).mp ((vaginal or intravaginal or mechanical) adj device*).mp pessar*.mp ((continence or incontinence) adj aid*).mp or/ and limit 23 to (meta analysis or systematic reviews) meta-analysis/ or meta-analysis as topic/ (meta analys* or metaanalys* or systematic review*).mp or and or (comment or letter or newspaper article or conference).pt not limit 31 to (yr="2005 -Current" and (danish or english or norwegian or swedish)) 29 Embase 1 exp urine incontinence/ urge incontinence/ stress incontinence/ ((stress or urge* or mix* or urin* or bladder) adj incontinence).mp incontinence, urine.mp incontinence, urinary.mp incontinentia urinae.mp urinary leak*.mp urine leak*.mp overactive bladder/ overactive bladder.mp OAB.mp or/ not prosta*.mp vagina pessary/ disposable equipment/ equipment design/ incontinence aid/ (continence adj (guard* or tampon*)).mp ((vaginal or intravaginal or mechanical) adj device*).mp pessar*.mp ((continence or incontinence) adj aid*).mp or/ and

10 25 meta analysis/ or "systematic review (topic)"/ or "systematic review"/ (meta analys* or metaanalys* or systematic review*).mp or and (comment or letter or newspaper article or conference).pt not limit 30 to ((danish or english or norwegian or swedish) and yr="2005 -Current") 18 Cinahl S31 S28 OR S29 Limiters - Published Date: ; Language: Danish, English, 16 Norwegian, Swedish S30 S28 OR S29 21 S29 S22 AND S23 Limiters - Publication Type: Meta Analysis, Meta Synthesis, Systematic 18 Review S28 S24 AND S27 18 S27 S25 OR S26 48,269 S26 meta analys* or metaanalys* or systematic review* 48,269 S25 (MH "Systematic Review") OR (MH "Meta Analysis") 33,229 S24 S22 AND S S23 s12 not prosta* 7,847 S22 S14 OR S15 OR S16 OR S17 OR S18 OR S19 OR S20 OR S21 24,152 S21 (continence or incontinence) aid* 787 S20 pessar* 242 S19 (vaginal or intravaginal or mechanical) device* 167 S18 continence (guard* or tampon*) 0 S17 (MH "Incontinence Aids") 772 S16 (MH "Equipment Design+") 21,858 S15 (MH "Disposable Equipment") 1,327 S14 (MH "Pessaries") 200 S13 S12 NOT prosta* 7,847 S12 S1 OR S2 OR S3 OR S4 OR S5 OR S6 OR S7 OR S8 OR S9 OR S10 OR S11 8,345 S11 overactive bladder OR OAB 1,000 S10 (MH "Overactive Bladder") 736 S9 urine leak* 88 S8 urinary leak* 51 S7 incontinentia urinae 0 S6 incontinence, urinary 25 S5 incontinence, urine 7 S4 (stress or urge* or mix* or urin* or bladder) incontinence 7,718 S3 (MH "Stress Incontinence") 1,517 S2 (MH "Urge Incontinence") 444 S1 (MH "Urinary Incontinence+") 7,003 10

11 Cochrane (34 Cochrane Reviews, 5 Other Reviews) #1 MeSH descriptor: [Urinary Incontinence] explode all trees 1617 #2 MeSH descriptor: [Urinary Incontinence, Urge] explode all trees 85 #3 MeSH descriptor: [Urinary Incontinence, Stress] explode all trees 697 #4 (stress or urge* or mix* or urin* or bladder) incontinence:ti,ab,kw (Word variations 4302 have been searched) #5 incontinence, urine:ti,ab,kw (Word variations have been searched) 962 #6 incontinence, urinary:ti,ab,kw (Word variations have been searched) 3643 #7 incontinentia urinae:ti,ab,kw (Word variations have been searched) 0 #8 urinary leak*:ti,ab,kw (Word variations have been searched) 512 #9 urine leak*:ti,ab,kw (Word variations have been searched) 292 #10 MeSH descriptor: [Urinary Bladder, Overactive] explode all trees 337 #11 overactive bladder or OAB:ti,ab,kw (Word variations have been searched) 1360 #12 #1 or #2 or #3 or #4 or #5 or #6 or #7 or #8 or #9 or #10 or # #13 #12 not prosta* 4650 #14 MeSH descriptor: [Pessaries] explode all trees 145 #15 MeSH descriptor: [Disposable Equipment] explode all trees 306 #16 MeSH descriptor: [Equipment Design] explode all trees 6332 #17 continence (guard* or tampon*) 23 #18 (vaginal or intravaginal or mechanical) device* 2271 #19 pessar* 431 #20 (continence or incontinence) aid* 294 #21 #14 or #15 or #16 or #17 or #18 or #19 or # #22 #13 and # PICO 4 (122 poster efter dubletsøgning) Medline 1 exp Dementia/ exp Memory Disorders/ Alzheimer Disease/ exp Neurodegenerative Diseases/ dementia.mp alzheimer*.mp cognitive deficit*.mp senile.mp mental deterioration.mp cognitive deterioration.mp brain deterioration.mp mental regression*.mp cognitive regression*.mp

12 14 brain regression*.mp neurodegenerative disease*.mp or/ exp Urinary Incontinence/ Urinary Incontinence, Urge/ Urinary Incontinence, Stress/ ((stress or urge* or mix* or urin* or bladder) adj incontinence).mp incontinence, urine.mp incontinence, urinary.mp incontinentia urinae.mp urinary leak*.mp urine leak*.mp Urinary Bladder, Overactive/ overactive bladder.mp OAB.mp or/ not prosta*.mp and limit 31 to (meta analysis or systematic reviews) meta-analysis/ or meta-analysis as topic/ (meta analys* or metaanalys* or systematic review*).mp or and or limit 37 to (yr="2005 -Current" and (danish or english or norwegian or swedish)) 26 Embase 1 exp cognitive defect/ exp dementia/ Alzheimer disease/ mental deterioration/ exp degenerative disease/ dementia.mp alzheimer*.mp cognitive deficit.mp senile.mp mental deterioration.mp cognitive deterioration.mp brain deterioration.mp mental regression*.mp cognitive regression*.mp brain regression*.mp neurodegenerative disease*.mp or/ exp urine incontinence/ urge incontinence/ stress incontinence/ ((stress or urge* or mix* or urin* or bladder) adj incontinence).mp incontinence, urine.mp incontinence, urinary.mp incontinentia urinae.mp

13 25 urinary leak*.mp urine leak*.mp overactive bladder/ overactive bladder.mp OAB.mp or/ not prosta*.mp and meta analysis/ or "systematic review (topic)"/ or "systematic review"/ (meta analys* or metaanalys* or systematic review*).mp or and (comment or letter or newspaper article or conference).pt not limit 38 to ((danish or english or norwegian or swedish) and yr="2005 -Current") 104 Cinahl S33 S30 OR S31 Limiters - Published Date: ; Language: Danish, English, Norwegian, Swedish 5 S32 S30 OR S31 7 Limiters - Publication Type: Meta Analysis, Meta S31 S11 AND S24 Synthesis, Systematic 6 Review S30 S25 AND S29 7 S29 S26 OR S27 OR S28 48,067 meta analys* or metaanalys* or systematic S28 review* 48,067 S27 (MH "Meta Analysis") 15,996 S26 (MH "Systematic Review") 22,397 S25 S11 AND S S24 S23 NOT prosta* 7,837 S12 OR S13 OR S14 OR S15 OR S16 OR S17 S23 OR S18 OR S19 OR S20 OR S21 OR S22 8,334 S22 overactive bladder OR OAB 998 S21 (MH "Overactive Bladder") 735 S20 urine leak* 88 S19 urinary leak* 51 S18 incontinentia urinae 0 S17 incontinence, urinary 25 S16 incontinence, urine 7 (stress or urge* or mix* or urin* or bladder) S15 incontinence 7,708 S14 (MH "Stress Incontinence") 1,513 13

14 S13 (MH "Urge Incontinence") 444 S12 (MH "Urinary Incontinence+") 6,989 S1 OR S2 OR S3 OR S4 OR S5 OR S6 OR S7 S11 OR S8 OR S9 OR S10 56,962 S10 neurodegenerative disease* 1,573 S9 (mental or cognitive or brain) regression* 11 S8 (mental or cognitive or brain) deterioration 215 S7 senile 802 S6 cognitive deficit 152 S5 alzheimer* 17,714 S4 dementia 28,896 S3 (MH "Neurodegenerative Diseases+") 31,972 S2 (MH "Alzheimer's Disease") 15,281 S1 (MH "Dementia+") 36,458 Cochrane (1 Cochrane Review, 1 Other Review) #1 MeSH descriptor: [Dementia] explode all trees #2 MeSH descriptor: [Memory Disorders] explode all trees #3 MeSH descriptor: [Alzheimer Disease] explode all trees #4 MeSH descriptor: [Neurodegenerative Diseases] explode all trees #5 dementia:ti,ab,kw (Word variations have been searched) #6 alzheimer*:ti,ab,kw (Word variations have been searched) #7 cognitive deficit*:ti,ab,kw (Word variations have been searched) #8 senile:ti,ab,kw (Word variations have been searched) #9 (mental or cognitive or brain) deterioration*:ti,ab,kw (Word variations have been searched) #10 (mental or cognitive or brain) regression*:ti,ab,kw (Word variations have been searched) #11 neurodegenerative disease*:ti,ab,kw (Word variations have been searched) #12 #1 or #2 or #3 or #4 or #5 or #5 or #6 or #7 or #8 or #9 or #10 or #11 #13 MeSH descriptor: [Urinary Incontinence] explode all trees #14 MeSH descriptor: [Urinary Incontinence, Urge] explode all trees #15 MeSH descriptor: [Urinary Incontinence, Stress] explode all trees #16 (stress or urge* or mix* or urin* or bladder) incontinence:ti,ab,kw (Word variations have been searched) #17 incontinence, urine:ti,ab,kw (Word variations have been searched) #18 incontinence, urinary:ti,ab,kw (Word variations have been searched) #19 incontinentia urinae:ti,ab,kw (Word variations have been searched) #20 urinary leak*:ti,ab,kw (Word variations have been searched) #21 urine leak*:ti,ab,kw (Word variations have been searched) #22 MeSH descriptor: [Urinary Bladder, Overactive] explode all trees #23 overactive bladder or OAB:ti,ab,kw (Word variations have been searched) #24 #13 or #14 or #15 or #16 or #17 or #18 or #19 or #20 or #21 or #22 or #23 #25 #24 not prosta* #26 #12 and #25 PEDro (8 hits) Problem: Subdiscipline: Incontinence Gerontology 14

15 Method: Systematic review Published Since: 2005 PICO 5 (68 poster efter dubletsøgning) Medline 1 Urinary Incontinence, Stress/ stress incontinence.mp (stress adj2 incontinence).mp SUI.mp Urinary Incontinence/ or/ exp Obesity/ exp Obesity, Morbid/ body mass index/ Body Weight/ (obesity or obese).mp (BMI or body mass index).mp overweight.mp or/ exp Weight Loss/ (weight adj3 (loss or reduction or decrease)).mp or and 14 and limit 18 to (meta analysis or systematic reviews) 9 20 meta-analysis/ or meta-analysis as topic/ (meta analys* or metaanalys* or systematic review*).mp or and or (comment or letter or newspaper article or conference).pt not limit 26 to (yr="2005 -Current" and (danish or english or norwegian or swedish)) 8 Embase 1 stress incontinence/ stress incontinence.mp (stress adj2 incontinence).mp SUI.mp urine incontinence/ or/ exp obesity/ morbid obesity/ body mass/ body weight/ (obesity or obese).mp

16 12 (BMI or body mass index).mp overweight.mp or/ exp weight reduction/ (weight adj3 (loss or reduction or decrease)).mp or and 14 and meta analysis/ or "systematic review (topic)"/ or "systematic review"/ (meta analys* or metaanalys* or systematic review*).mp or and (comment or letter or newspaper article or conference).pt not limit 24 to ((danish or english or norwegian or swedish) and yr="2005 -Current") 14 Cinahl S27 S24 OR S25 Limiters - Published Date: ; Language: Danish, English, 3 Norwegian, Swedish S26 S24 OR S25 3 S25 S7 AND S15 AND S19 Limiters - Publication Type: Meta Analysis, Meta Synthesis, Systematic 2 Review S24 S20 AND S23 3 S23 S21 OR S22 48,269 S22 meta analys* or metaanalys* or systematic review* 48,269 S21 (MH "Systematic Review") OR (MH "Meta Analysis") 33,229 S20 S7 AND S15 AND S19 51 S19 S16 OR S17 OR S18 15,488 S18 (loss of or reduction of or decrease of) weight 440 S17 (weight (loss or reduction or decrease) 15,346 S16 (MH "Weight Loss") 9,771 S15 S8 OR S9 OR S10 OR S11 OR S12 OR S13 OR S14 95,843 S14 overweight 9,451 S13 BMI or body mass index 45,282 S12 obesity or obese 47,579 S11 (MH "Body Weight+") 60,675 S10 (MH "Body Mass Index") 34,599 S9 (MH "Obesity, Morbid") 1,586 S8 (MH "Obesity+") 38,767 S7 S1 OR S2 OR S3 OR S4 OR S5 OR S6 6,911 S6 (MH "Urinary Incontinence") 5,625 S5 SUI 211 S4 urin* stress incontinence 62 S3 stress urin* incontinence 556 S2 stress incontinence 1,671 S1 (MH "Stress Incontinence") 1,517 16

17 Cochrane (48 Cochrane Reviews, 2 Other Reviews) #1 MeSH descriptor: [Urinary Incontinence, Stress] explode all trees 697 #2 stress incontinence 1968 #3 stress urin* incontinence 1718 #4 urin* stress incontinence 1718 #5 SUI 578 #6 MeSH descriptor: [Urinary Incontinence] explode all trees 1617 #7 #1 or #2 or #3 or #4 or #5 or # #8 MeSH descriptor: [Obesity] explode all trees 7887 #9 MeSH descriptor: [Obesity, Morbid] explode all trees 668 #10 MeSH descriptor: [Body Mass Index] explode all trees 6220 #11 MeSH descriptor: [Body Weight] explode all trees #12 obesity or obese #13 BMI or body mass index #14 overweight 6111 #15 #8 or #9 or #10 or #11 or #12 or #13 or # #16 MeSH descriptor: [Weight Loss] explode all trees 3713 #17 weight loss #18 weight reduction #19 weight decrease 7703 #20 #16 or #17 or #18 or # #21 #7 and #15 and #20 79 PICO 6 (35 poster efter dubletsøgning) Medline 1 Urinary Incontinence, Stress/ stress incontinence.mp (stress adj2 incontinence).mp SUI.mp or/ exp Exercise Therapy/ exp Muscle Contraction/ Muscle Strength/ exp Physical Therapy Modalities/ (pelvic floor muscle training or PFMT).mp (pelvic floor adj3 (train* or exercis*)).mp (pelvic muscle adj3 (train* or exercis*)).mp (physical therap* or physioterap*).mp (kegel or kegels).mp exp Biofeedback, Psychology/

18 16 biofeedback.mp or/ Suburethral Slings/ TVT.mp TVT-O.mp (tension* adj3 (tape* or sling*)).mp (transobturator adj3 (tape* or sling*)).mp (midurethral adj (sling* or tape*)).mp (mid-urethral adj (sling* or tape*)).mp (suburethral adj (sling* or tape*)).mp retropubic tension free sling*.mp ((sling* or tape*) adj3 (surg* or operat*)).mp MUS.mp or/ and 17 and limit 30 to (meta analysis or systematic reviews) meta-analysis/ or meta-analysis as topic/ (meta analys* or metaanalys* or systematic review*).mp or and or limit 36 to (yr="2005 -Current" and (danish or english or norwegian or swedish)) 10 Embase 1 stress incontinence/ stress incontinence.mp (stress adj2 incontinence).mp SUI.mp or/ pelvic floor muscle training/ exp kinesiotherapy/ exp muscle contraction/ muscle strength/ exp physiotherapy/ (pelvic floor muscle training or PFMT).mp (pelvic floor adj3 (train* or excercis*)).mp (pelvic muscle adj3 (train* or exercis*)).mp exercise therapy.mp (physical therap* or physioterap*).mp (kegel or kegels).mp exp feedback system/ biofeedback.mp or/ exp suburethral sling/ tension free vaginal tape/ transobturator tape/ TVT.mp TVT-O.mp (tension* adj3 (tape* or sling*)).mp (transobturator adj3 (tape* or sling*)).mp

19 27 (midurethral adj (sling* or tape*)).mp (mid-urethral adj (sling* or tape*)).mp (suburethral adj (sling* or tape*)).mp retropubic tension free sling*.mp ((sling* or tape*) adj3 (surg* or operat*)).mp MUS.mp or/ and 19 and meta analysis/ or "systematic review (topic)"/ or "systematic review"/ (meta analys* or metaanalys* or systematic review*).mp or and (comment or letter or newspaper article or conference).pt not limit 40 to ((danish or english or norwegian or swedish) and yr="2005 -Current") 12 Cinahl S45 S42 OR S43 Limiters - Published Date: ; Language: 2 Danish, English, Norwegian, Swedish S44 S42 OR S43 3 S43 S5 AND S19 AND S37 Limiters - Publication Type: Meta Analysis, Meta Synthesis, 3 Systematic Review S42 S38 AND S41 3 S41 S39 OR S40 48,119 S40 meta analys* or metaanalys* or systematic review* 48,119 S39 (MH "Systematic Review") OR (MH "Meta Analysis") 33,143 S38 S5 AND S19 AND S37 19 S37 S20 OR S21 OR S22 OR S23 OR S24 OR S25 OR S26 OR S27 OR S28 OR S29 OR S30 OR S31 OR 502 S32 OR S33 OR S34 OR S35 OR S36 S36 MUS 117 S35 sub-urethral (sling* OR tape*) 2 S34 suburethral (sling* OR tape*) 260 S33 tension free transvaginal tape* 0 S32 retropubic tension free sling* 0 S31 mid-urethral (sling* OR tape*) 18 S30 midurethral (sling* OR tape*) 69 S29 midurethral sling* 68 S28 transobturator suburethral tape 4 S27 transobturator sling* 18 S26 transobturator tape* 39 S25 tension free vaginal sling* 0 S24 tensionless vaginal tape* 0 S23 tension free vaginal tape* 122 S22 TVT-O 6 19

20 S21 TVT 75 S20 (MH "Suburethral Slings") 235 S19 S6 OR S7 OR S8 OR S9 OR S10 OR S11 OR S12 OR S13 OR S14 OR S15 OR S16 OR S17 OR S18 100,852 S18 biofeedback 2,493 S17 (MH "Biofeedback") 2,133 S16 exercise therap* Display S15 kegel or kegels Display S14 physical therap* or physioterap* Display S13 pelvic floor muscle exercis* Display S12 pelvic muscle (train* or exercis*) Display S11 pelvic floor (train* or exercis*) Display S10 ( pelvic floor muscle training or PFMT ) OR PFMT Display S9 (MH "Physical Therapy+") Display S8 (MH "Muscle Contraction+") Display S7 (MH "Muscle Strength+") OR (MH "Muscle Strengthening+") Display S6 (MH "Kegel Exercises") Display S5 S1 OR S2 OR S3 OR S4 1,791 S4 SUI 211 S3 stress urin* incontinence 555 S2 stress incontinence 1,671 S1 (MH "Stress Incontinence") 1,517 Cochrane (16 Cochrane Reviews, 3 Other Reviews) #1 MeSH descriptor: [Urinary Incontinence, Stress] explode all trees #2 stress incontinence #3 stress urin* incontinence #4 SUI #5 #1 or #2 or #3 or #4 #6 MeSH descriptor: [Exercise Therapy] explode all trees #7 MeSH descriptor: [Muscle Contraction] explode all trees #8 MeSH descriptor: [Muscle Strength] explode all trees #9 MeSH descriptor: [Physical Therapy Modalities] explode all trees #10 pelvic floor muscle training or PFMT:ti,ab,kw (Word variations have been searched) #11 pelvic floor (train* or exercis*):ti,ab,kw (Word variations have been searched) #12 pelvic muscle (train* or exercis*):ti,ab,kw (Word variations have been searched) #13 pelvic floor muscle exercis*:ti,ab,kw (Word variations have been searched) #14 physical therap* or physioterap*:ti,ab,kw (Word variations have been searched) #15 kegel or kegels:ti,ab,kw (Word variations have been searched) #16 exercise therap*:ti,ab,kw (Word variations have been searched) #17 MeSH descriptor: [Biofeedback, Psychology] explode all trees #18 biofeedback #19 #6 or #7 or #8 or #9 or #10 or #11 or #12 or #13 or #14 or #15 or #16 or #17 or #18 #20 MeSH descriptor: [Suburethral Slings] explode all trees #21 TVT #22 TVT-O #23 tension free vaginal tape* #24 tensionless vaginal tape* #25 tension free vaginal sling* #26 transobturator tape* 20

21 #27 transobturator sling* #28 transobturator suburethral tape #29 midurethral (sling* or tape*) #30 mid-urethral (sling* or tape*) #31 retropubic tension free sling* #32 tension free transvaginal tape* #33 suburethral (sling* or tape*) #34 sub-urethral (sling* or tape*) #35 MUS #36 #20 or #21 or #22 or #23 or #24 or #25 or #26 or #27 or #28 or #29 or #30 or #31 or #32 or #33 or #34 or #35 #37 #5 and #19 and #36 PICO 7 (32 poster efter dubletsøgning) Medline 1 Urinary Incontinence, Stress/ stress incontinence.mp (stress adj2 incontinence).mp SUI.mp Urinary Incontinence/ or/ exp Obesity/ exp Obesity, Morbid/ body mass index/ Body Weight/ (obesity or obese).mp (BMI or body mass index).mp overweight.mp or/ exp suburethral sling/ TVT.mp TVT-O.mp (tension* adj3 (tape* or sling*)).mp (transobturator adj3 (tape* or sling*)).mp TOT.mp (midurethral adj (sling* or tape*)).mp (mid-urethral adj (sling* or tape*)).mp (suburethral adj (sling* or tape*)).mp retropubic tension free sling*.mp ((sling* or tape*) adj3 (surg* or operat*)).mp MUS.mp or/ and 14 and limit 28 to (meta analysis or systematic reviews) meta-analysis/ or meta-analysis as topic/ (meta analys* or metaanalys* or systematic review*).mp or and

22 34 29 or limit 34 to (yr="2005 -Current" and (danish or english or norwegian or swedish)) 7 Embase 1 stress incontinence/ stress incontinence.mp (stress adj2 incontinence).mp SUI.mp urine incontinence/ or/ exp obesity/ morbid obesity/ body mass/ body weight/ (obesity or obese).mp (BMI or body mass index).mp overweight.mp or/ exp suburethral sling/ tension free vaginal tape/ transobturator tape/ TVT.mp TVT-O.mp (tension* adj3 (tape* or sling*)).mp (transobturator adj3 (tape* or sling*)).mp TOT.mp (midurethral adj (sling* or tape*)).mp (mid-urethral adj (sling* or tape*)).mp (suburethral adj (sling* or tape*)).mp retropubic tension free sling*.mp ((sling* or tape*) adj3 (surg* or operat*)).mp MUS.mp or/ and 14 and meta analysis/ or "systematic review (topic)"/ or "systematic review"/ (meta analys* or metaanalys* or systematic review*).mp or and (comment or letter or newspaper article or conference).pt not limit 36 to ((danish or english or norwegian or swedish) and yr="2005 -Current") 8 22

23 Cinahl S40 S37 OR S38 Limiters - Published Date: ; Language: Danish, English, Norwegian, Swedish 1 S39 S37 OR S38 1 Limiters - Publication Type: Meta Analysis, Meta Synthesis, Systematic Review 1 S38 S7 AND S15 AND S32 S37 S33 AND S36 1 S36 S34 OR S35 48,269 S35 meta analys* or metaanalys* or systematic review* 48,269 S34 (MH "Systematic Review") OR (MH "Meta Analysis") 33,229 S33 S7 AND S15 AND S32 19 S16 OR S17 OR S18 OR S19 OR S20 OR S21 OR S22 OR S23 OR S24 OR S25 OR S26 OR S27 OR S28 OR S29 OR S30 OR S S32 S31 MUS 117 S30 sub-urethral (sling* OR tape*) 2 S29 suburethral (sling* OR tape*) 260 S28 TOT 159 S27 tension free transvaginal tape* 0 S26 retropubic tension free sling* 0 S25 mid-urethral (sling* OR tape*) 18 S24 midurethral (sling* OR tape*) 70 S23 transobturator suburethral tape* 5 S22 transobturator (tape* OR sling*) 57 S21 tension free vaginal sling* 0 S20 tensionless vaginal tape* 0 S19 tension free vaginal tape* 122 S18 TVT-O 6 S17 TVT 75 S16 (MH "Suburethral Slings") 235 S15 S8 OR S9 OR S10 OR S11 OR S12 OR S13 OR S14 95,843 S14 overweight 9,451 S13 BMI or body mass index 45,282 S12 obesity or obese 47,579 S11 (MH "Body Weight+") 60,675 S10 (MH "Body Mass Index") 34,599 S9 (MH "Obesity, Morbid") 1,586 S8 (MH "Obesity+") 38,767 S7 S1 OR S2 OR S3 OR S4 OR S5 OR S6 6,911 S6 (MH "Urinary Incontinence") 5,625 S5 SUI 211 S4 urin* stress incontinence 62 S3 stress urin* incontinence 556 S2 stress incontinence 1,671 S1 (MH "Stress Incontinence") 1,517 23

24 Cochrane (15 Cochrane Reviews, 2 Other Reviews) #1 MeSH descriptor: [Urinary Incontinence, Stress] explode all trees 697 #2 stress incontinence 1968 #3 stress urin* incontinence 1718 #4 urin* stress incontinence 1718 #5 SUI 578 #6 MeSH descriptor: [Urinary Incontinence] explode all trees 1617 #7 #1 or #2 or #3 or #4 or #5 or # #8 MeSH descriptor: [Obesity] explode all trees 7887 #9 MeSH descriptor: [Obesity, Morbid] explode all trees 668 #10 MeSH descriptor: [Body Mass Index] explode all trees 6220 #11 MeSH descriptor: [Body Weight] explode all trees #12 obesity or obese #13 BMI or body mass index #14 overweight 6111 #15 #8 or #9 or #10 or #11 or #12 or #13 or # #16 TVT 432 #17 TVT-O 154 #18 tension free vaginal tape* 369 #19 tensionless vaginal tape* 2 #20 tension free vaginal sling* 193 #21 transobturator (tape* or sling*) 275 #22 transobturator suburethral tape* 103 #23 midurethral (sling* or tape*) 106 #24 mid-urethral (sling* or tape*) 89 #25 retropubic tension free sling* 62 #26 tension free transvaginal tape* 18 #27 TOT 364 #28 suburethral (sling* or tape*) 349 #29 sub-urethral (sling* or tape*) 15 #30 MUS 253 #31 #16 or #17 or #18 or #19 or #20 or #21 or #22 or #23 or #24 or #25 or #26 or # or #28 or #29 or #30 #32 #7 and #15 and #31 49 PICO 8 (90 poster efter dubletsøgning) Medline 1 Urinary Incontinence, Stress/ stress incontinence.mp (stress adj2 incontinence).mp SUI.mp Urinary Incontinence/ or/

25 7 exp Suburethral Slings/ TVT.mp TVT-O.mp (tension* adj3 (tape* or sling*)).mp (transobturator adj3 (tape* or sling*)).mp TOT.mp (midurethral adj (sling* or tape*)).mp (mid-urethral adj (sling* or tape*)).mp (suburethral adj (sling* or tape*)).mp retropubic tension free sling*.mp ((sling* or tape*) adj3 (surg* or operat*)).mp MUS.mp or/ and limit 20 to (meta analysis or systematic reviews) meta analysis/ or "systematic review (topic)"/ or "systematic review"/ (meta analys* or metaanalys* or systematic review*).mp or and or (comment or letter or newspaper article or conference).pt not limit 28 to (yr="2012 -Current" and (danish or english or norwegian or swedish)) 44 Embase 1 stress incontinence/ stress incontinence.mp (stress adj2 incontinence).mp SUI.mp urine incontinence/ or/ exp suburethral sling/ tension free vaginal tape/ transobturator tape/ TVT.mp TVT-O.mp (tension* adj3 (tape* or sling*)).mp (transobturator adj3 (tape* or sling*)).mp TOT.mp (midurethral adj (sling* or tape*)).mp (mid-urethral adj (sling* or tape*)).mp (suburethral adj (sling* or tape*)).mp retropubic tension free sling*.mp ((sling* or tape*) adj3 (surg* or operat*)).mp MUS.mp or/ and meta analysis/ or "systematic review (topic)"/ or "systematic review"/ (meta analys* or metaanalys* or systematic review*).mp or and

26 27 (comment or letter or newspaper article or conference).pt not limit 28 to ((danish or english or norwegian or swedish) and yr="2012 -Current") 61 Cinahl S32 S29 OR S30 Limiters - Published Date: ; Language: 6 Danish, English, Norwegian, Swedish S31 S29 OR S30 17 S30 S17 AND S24 Limiters - Publication Type: Meta Analysis, Meta Synthesis, 15 Systematic Review S29 S25 AND S28 17 S28 S26 OR S27 48,121 S27 meta analys* or metaanalys* or systematic review* 48,121 S26 (MH "Systematic Review") OR (MH "Meta Analysis") 33,143 S25 S17 AND S S24 S18 OR S19 OR S20 OR S21 OR S22 OR S23 7,100 S23 (MH "Urinary Incontinence+") 7,001 S22 SUI 211 S21 Urin* stress incontinence 62 S20 Stress urin* incontinence 555 S19 stress incontinence 1,671 S18 (MH "Stress Incontinence") 1,517 S17 S1 OR S2 OR S3 OR S4 OR S5 OR S6 OR S7 OR S8 OR S9 OR S10 OR S11 OR S12 OR S13 OR S14 OR 647 S15 OR S16 S16 MUS 117 S15 sub-urethral (sling* OR tape*) 2 S14 suburethral (sling* OR tape*) 260 S13 TOT 159 S12 tension free transvaginal tape* 0 S11 retropubic tension free sling* 0 S10 mid-urethral (sling* OR tape*) 18 S9 midurethral (sling* OR tape*) 69 S8 transobturator suburethral tape* 5 S7 transobturator (tape* OR sling*) 57 S6 tension free vaginal sling* 0 S5 tensionless vaginal tape* 0 S4 tension free vaginal tape* 122 S3 TVT-O 6 S2 TVT 75 S1 (MH "Suburethral Slings")

27 Cochrane (13 Cochrane Reviews, 16 Other Reviews) #1 MeSH descriptor: [Urinary Incontinence, Stress] explode all trees 697 #2 stress incontinence 1968 #3 stress urin* incontinence 1718 #4 urin* stress incontinence 1718 #5 SUI 578 #6 MeSH descriptor: [Urinary Incontinence] explode all trees 1617 #7 #1 or #2 or #3 or #4 or #5 or # #8 TVT 432 #9 TVT-O 154 #10 tension free vaginal tape* 369 #11 tensionless vaginal tape* 2 #12 tension free vaginal sling* 193 #13 transobturator (tape* or sling*) 275 #14 transobturator suburethral tape* 103 #15 midurethral (sling* or tape*) 106 #16 mid-urethral (sling* or tape*) 89 #17 retropubic tension free sling* 62 #18 tension free transvaginal tape* 18 #19 TOT 364 #20 suburethral (sling* or tape*) 349 #21 sub-urethral (sling* or tape*) 15 #22 MUS 253 #23 #8 or #9 or #10 or #11 or #12 or #13 or #14 or #15 or #16 or #17 or #18 or # or #20 or #21 or #22 #24 #7 and # PICO 9 (49 poster efter dubletsøgning) Medline 1 Urinary Incontinence, Urge/ Urinary Bladder, Overactive/ Urinary Incontinence/ overactive detrusor function.mp overactive bladder.mp OAB.mp Urge* incontinence.mp Urin* incontinence.mp or/ Postmenopause/ (postmenopaus* or post menopaus*).mp or Estrogen Replacement Therapy/ (estrogen* or oestrogen*).mp or and 12 and

28 17 limit 16 to (meta analysis or systematic reviews) meta-analysis/ or meta-analysis as topic/ (meta analys* or metaanalys* or systematic review*).mp or and or (comment or letter or newspaper article or conference).pt not limit 24 to (yr="2005 -Current" and (danish or english or norwegian or swedish)) 11 Embase 1 urge incontinence/ overactive bladder/ urine incontinence/ overactive detrusor function.mp overactive bladder.mp OAB.mp Urge* incontinence.mp Urin* incontinence.mp or/ postmenopause/ (postmenopaus* or post menopaus*).mp or estrogen therapy/ (estrogen* or oestrogen*).mp or and 12 and meta analysis/ or "systematic review (topic)"/ or "systematic review"/ (meta analys* or metaanalys* or systematic review*).mp or and (comment or letter or newspaper article or conference).pt not limit 22 to ((danish or english or norwegian or swedish) and yr=" ") 21 Cinahl S23 S20 OR S21 Limiters - Published Date: ; Language: 5 Danish, English, Norwegian, Swedish S22 S20 OR S21 7 S21 S9 AND S12 AND S15 Limiters - Publication Type: Meta Analysis, Meta Synthesis, 3 Systematic Review S20 S16 AND S

29 S19 S17 OR S18 48,119 S18 meta analys* or metaanalys* or systematic review* 48,119 S17 (MH "Systematic Review") OR (MH "Meta Analysis") 33,143 S16 S9 AND S12 AND S15 73 S15 S13 OR S14 13,161 S14 estrogen* OR oestrogen* 9,463 S13 (MH "Hormone Replacement Therapy+") 6,441 S12 S10 OR S11 8,625 S11 Post menopaus* OR Postmenopaus* 8,625 S10 (MH "Postmenopause") 5,555 S9 S1 OR S2 OR S3 OR S4 OR S5 OR S6 OR S7 OR S8 8,237 S8 Urin* incontinence 6,751 S7 Urge* incontinence 624 S6 OAB 257 S5 overactive bladder 985 S4 overactive destrusor function 0 S3 (MH "Urinary Incontinence+") 7,001 S2 (MH "Overactive Bladder") 736 S1 (MH "Urge Incontinence") 444 Cochrane (23 Cochrane Reviews) #1 MeSH descriptor: [Urinary Incontinence, Urge] explode all trees 85 #2 MeSH descriptor: [Urinary Bladder, Overactive] explode all trees 337 #3 MeSH descriptor: [Urinary Incontinence] explode all trees 1617 #4 Overactive Detrusor Function 56 #5 Overactive bladder 1360 #6 OAB 538 #7 Urge* incontinence 1358 #8 Urin* incontinence 4154 #9 #1 or #2 or #3 or #4 or #5 or #6 or #7 or # #10 MeSH descriptor: [Postmenopause] explode all trees 3935 #11 Post menopaus* or postmenopaus* #12 #10 or # #13 MeSH descriptor: [Estrogen Replacement Therapy] explode all trees 2079 #14 estrogen* or oestrogen*:ti,ab,kw (Word variations have been searched) 8776 #15 #13 or # #16 #9 and #12 and #15 79 PICO 10 (337 poster efter dubletsøgning) Medline 1 Urinary Incontinence, Urge/ Urinary Bladder, Overactive/ Urinary Incontinence/ overactive detrusor function.mp overactive bladder.mp

30 6 OAB.mp Urge* incontinence.mp Urin* incontinence.mp or/ Adrenergic beta-3 Receptor Agonists/ Adrenergic beta3 Agonist*.mp beta3-adrenergic receptor agonist*.mp adrenergic beta 3 receptor agonist*.mp beta 3 adrenergic agonist*.mp beta 3 adrenergic receptor*.mp beta 3 adrenergic stimula*.mp beta3 adrenergic.mp beta 3 adrenoceptor*.mp beta3 adrenoceptor*.mp or/ Cholinergic Antagonists/ Muscarinic Antagonists/ Cholinergic Antagonist*.mp Anticholinergic Agent*.mp Anticholinergic*.mp Anti Cholinergic*.mp Cholinergic Blocking Agent*.mp cholinergic blocker*.mp Antimuscarinic*.mp Muscarinic Antagonist*.mp muscarinic blocker*.mp or/ or and meta-analysis/ or meta-analysis as topic/ (meta analys* or metaanalys* or systematic review*).mp or and limit 34 to (meta analysis or systematic reviews) or (comment or letter or newspaper article or conference).pt not limit 42 to (yr="2005 -Current" and (danish or english or norwegian or swedish)) 147 Embase 1 urge incontinence/ overactive bladder/ urine incontinence/ overactive detrusor function.mp overactive bladder.mp OAB.mp Urge* incontinence.mp Urin* incontinence.mp or/ beta 3 adrenergic receptor stimulating agent/ Adrenergic beta3 Agonist*.mp. 3 30

31 12 beta3-adrenergic receptor agonist*.mp adrenergic beta 3 receptor agonist*.mp beta 3 adrenergic agonist*.mp beta 3 adrenergic receptor*.mp beta 3 adrenergic stimula*.mp beta3 adrenergic.mp beta 3 adrenoceptor*.mp beta3 adrenoceptor*.mp or/ cholinergic receptor blocking agent/ muscarinic receptor blocking agent/ Cholinergic Antagonist*.mp Anticholinergic Agent*.mp Anticholinergic*.mp Anti Cholinergic*.mp Cholinergic Blocking Agent*.mp cholinergic blocker*.mp Antimuscarinic*.mp Muscarinic Antagonist*.mp muscarinic blocker*.mp or/ or and meta analysis/ or "systematic review (topic)"/ or "systematic review"/ (meta analys* or metaanalys* or systematic review*).mp or and (comment or letter or newspaper article or conference).pt not limit 40 to ((danish or english or norwegian or swedish) and yr="2005 -Current") 191 Cinahl S41 S38 OR S39 Limiters - Published Date: ; Language: Danish, English, Norwegian, Swedish 37 S40 S38 OR S39 46 Limiters - Publication Type: Meta Analysis, Meta Synthesis, Systematic Review 31 S39 S32 AND S33 S38 S34 AND S37 43 S37 S35 OR S36 48,276 S36 meta analys* or metaanalys* or systematic review* 48,276 (MH "Systematic Review") OR (MH "Meta S35 Analysis") 33,229 S34 S32 AND S S1 OR S2 OR S3 OR S4 OR S5 OR S6 OR S7 OR S33 S8 8,242 S32 S19 OR S31 11,055 31

32 S31 S20 OR S21 OR S22 OR S23 OR S24 OR S25 OR S26 OR S27 OR S28 OR S29 OR S30 3,559 S30 muscarinic blocker 0 S29 Muscarinic Antagonist* 480 S28 Antimuscarinic* 184 S27 cholinergic blocker 0 S26 Cholinergic Blocking Agents 1 S25 Anti Cholinergics 6 S24 Anticholinergic* 978 S23 Anticholinergic Agent* 140 S22 Cholinergic Antagonist* 1,049 S21 (MH "Muscarinic Antagonists+") 1,483 S20 (MH "Cholinergic Antagonists+") 2,964 S9 OR S10 OR S11 OR S12 OR S13 OR S14 OR S19 S15 OR S16 OR S17 OR S18 7,945 S18 beta3 adrenoceptor* 20 S17 beta 3 adrenoceptor* 20 S16 beta3 adrenergic 20 S15 beta 3 adrenergic stimula* 2 S14 beta 3 adrenergic receptor* 17 S13 beta 3 adrenergic agonist* 2 S12 adrenergic beta 3 receptor agonist* 0 S11 Adrenergic beta3 Agonist* 0 S10 beta3-adrenergic receptor agonist* 4 S9 (MH "Adrenergic Beta-Agonists+") 7,918 S8 Urin* incontinence 6,755 S7 Urge* incontinence 624 S6 OAB 257 S5 overactive bladder 986 S4 overactive destrusor function 0 S3 (MH "Urinary Incontinence+") 7,003 S2 (MH "Overactive Bladder") 736 S1 (MH "Urge Incontinence") 444 Cochrane (74 Cochrane Reviews, 17 Other Reviews) #1 MeSH descriptor: [Urinary Incontinence, Urge] explode all trees 85 #2 MeSH descriptor: [Urinary Bladder, Overactive] explode all trees 337 #3 MeSH descriptor: [Urinary Incontinence] explode all trees 1617 #4 Overactive Detrusor Function 56 #5 Overactive bladder 1360 #6 OAB 538 #7 Urge* incontinence 1358 #8 Urin* incontinence 4154 #9 #1 or #2 or #3 or #4 or #5 or #6 or #7 or # #10 MeSH descriptor: [Adrenergic beta-3 Receptor Agonists] explode all trees 18 #11 Adrenergic beta3 Agonist* 24 #12 beta3-adrenergic receptor agonist* 2 #13 adrenergic beta 3 receptor agonist* 558 #14 beta 3 adrenergic agonist* 1544 #15 beta 3 adrenergic receptor* 2433 #16 beta 3 adrenergic stimula*

33 #17 beta3 adrenergic 32 #18 beta 3 adrenoceptor* 957 #19 beta3 adrenoceptor* 38 #20 #10 or #11 or #12 or #13 or #14 or #15 or #16 or #17 or #18 or # #21 MeSH descriptor: [Cholinergic Antagonists] explode all trees 935 #22 MeSH descriptor: [Muscarinic Antagonists] explode all trees 611 #23 Cholinergic Antagonist* 692 #24 Anticholinergic Agent* 1211 #25 Anticholinergic* 2569 #26 Anti Cholinergics 30 #27 Cholinergic Blocking Agent* 404 #28 cholinergic blocker 81 #29 Antimuscarinic* 473 #30 Muscarinic Antagonist* 968 #31 muscarinic blocker 46 #32 #21 or #22 or #23 or #24 or #25 or #26 or #27 or #28 or #29 or #30 or # #33 #20 or # #34 #9 and #