Diagnóstico y Terapias Locales
|
|
|
- Gavin Burke
- 8 years ago
- Views:
Transcription
1 Diagnóstico y Terapias Locales Dra Marga Majem Hospital de la Santa Creu i Sant Pau
2 AGENDA Revised (8th) Edition of TNM Staging System for Lung Cancer Surgical Approaches in Localized Lung Cancer Radiation for Localized Lung Cancer
3 AGENDA Revised (8th) Edition of TNM Staging System for Lung Cancer Surgical Approaches in Localized Lung Cancer Radiation for Localized Lung Cancer
4 Database for the 8th edition (Timelines: ) Region Number % Europe 46, Asia 41, North America 4,660 5 Australia 1, South America TOTAL 94, Rami-Porta R et al. J Thorac Oncol 2014; 9: Presentation Number: Revised (8th) edition of TNM staging system for lung cancer Ramón Rami-Porta
5 T recommendations Descriptor 7th edition Proposal for 8th edition </= 1 cm T1a T1a > 1-2 cm T1a T1b > 2-3 cm T1b T1c > 3-4 cm T2a T2a > 4-5 cm T2a T2b > 5-7 cm T2b T3 > 7 cm T3 T4 Bronchus < 2 cm T3 T2 Complete atelectasis/pneumonitis T3 T2 Diaphragm invasion T3 T4 Mediastinal pleura T3 - Size: every cm counts (T1a-c) T2 & T3 endobronchial: same prognosis T2 & T3 atelectasis: same prognosis T3 diaphragm has a T4 prognosis T3 mediastinalpleura, rarely used Presentation Number: Revised (8th) edition of TNM staging system for lung cancer Ramón Rami-Porta
6
7 N recommendations To keep the present descriptors as they are To propose new descriptors for prospective testing: pn1a: single pn1 nodal station pn1b: multiple pn1 nodal stations pn2a1: single pn2 nodal station without pn1 (skip pn2) pn2a2: single pn2 nodal station with pn1 pn2b: multiple pn2 nodal stations N3: no changes M recommendations M1a: as it is M1b: single metastasis in a single organ M1c: multiple metastases in a single organ or in several organs Presentation Number: Revised (8th) edition of TNM staging system for lung cancer Ramón Rami-Porta Asamura H et al. JTO 2015; in press. Eberhardt W et al. JTO 2015; in press.
8 STAGING proposals N0 N1 N2 N3 M1a any N M1b any N M1c any N T1a IA1 IIB IIIA IIIB IVA IVA IVB T1b IA2 IIB IIIA IIIB IVA IVA IVB T1c IA3 IIB IIIA IIIB IVA IVA IVB T2a IB IIB IIIA IIIB IVA IVA IVB T2b IIA IIB IIIA IIIB IVA IVA IVB T3 IIB IIIA IIIB IIIC IVA IVA IVB T4 IIIA IIIA IIIB IIIC IVA IVA IVB Presentation Number: Revised (8th) edition of TNM staging system for lung cancer Ramón Rami-Porta
9 AGENDA Revised (8th) Edition of TNM Staging System for Lung Cancer Surgical Approaches in Localized Lung Cancer Radiation for Localized Lung Cancer
10
11 PRINCIPLES OF SURGICAL THERAPY Resection is the preferred local treatment RESECTION Anatomic pulmonary resectionis preferred for the majority of patients Sublobar resection: segmentectomy and wedge resection with: Margins > 2 cm or > the nodule size Appropriate N1 &N2 sampling Sublobar / wedge resection is appropriatein: Poor pulmonary reserve or major comorbidity that contraindicates lobectomy. Peripheral nodule < 2 cm with at least one of the following: Pure AIS histology. > 50% GGO in CT. Long doubling time (> 400 days) in radiologic surveillance.
12 PRINCIPLES OF RADIATION THERAPY Early-stage NSCLC (Stage I) SBRT is recommended for inoperable patients or those who refuse surgery. SBRT is appropriate for high surgical risk patients (do not tolerate lobectomy). SBRT comparable disease control rate and OS to lobectomy in operable disease. TheLancet, May 14, 2015: similar efficacy, lesstoxicity withsbrt
13 Surgical Approaches in Localized Lung Cancer ORAL Wedge Resection vs Segmentectomy for Patients with T1A N0 Non-Small Cell Lung Cancer ORAL Salvage Surgery for Local Failures after Stereotactic Ablative Radiotherapy for Lung Malignancies ORAL The Role of Surgical Mediastinal Resection in CT Screen-Detected Lung Cancer Patients ORAL The Feasibility and Safety of Complete VATS for NSCLC Under Non-Intubated Intravenous Anesthesia in Comparison with Intubated Anesthesia
14 ORAL What is better?
15 Wedge resection might have lower perioperative mortality than lobectomy or segmentectomy. Retrospective database analysis Objective: To assess outcomes of patients who underwent wedge resection or segmentectomyfor stage T1aN0 NSCLC No differences in pts characteristics (1230 each arm)
16 CONCLUSIONS SegmentectomyforT1aN0M0 NSCLC patienthas betteros evenin < 1 cm tumors and forpatientswithno comorbidities Segmentectomyshouldbe thepreferred sublobar resectionfor ct1an0 NSCLC
17 ORAL 35.03
18 1 out of 4 lung tumors that are medically operable prefers SBRT. Carefully follow-up and early detection of local recurrence is critical. Limited information of salvage surgery after SBRT. MATERIAL AND METHODS 9 ptshad recurrence of early NSCLC 8 ptshad recurrence of lung mets, 4 ptstreated for lung mets underwent 2 separate resections for local recurrence
19 16/21 hadno furtherprogression OS aftersurgery: Median: 38 m 1 year: 100% 2 years: 80% CONCLUSIONS: Salvagesurgery for isolatedlocal recurrenceafterlung SBRT is feasiblewithoutmajorcomplications
20 ORAL35.05
21 Therapeutic value of MLNR continues to be a source of debate ACOSOG Z0030 trial: OS similar in early cancer with regard to complete LN resection vs LN sampling. Hypothesis: is MLNR necessary in small tumors detected by screening? I-ELCAP DATABASE RESECTED NSCLC More lobectomy and central tumors in the MLNR group
22 CONCLUSIONS For patients with small screen-diagnosed NSCLC it seems reasonable not to perform lymph node sampling, particularly in subsolidnodules. Future prospective studies are needed
23 ORAL 35.07
24 INTRODUCTION VATS usually performed under general anesthesiawith single-lung ventilation (GATI) Retrospective analysis of patients who received VATS radical resection of lung cancer under IV anesthesiawith spontaneous brathing (IASB) over 3 years
25 RESULTS Significantly lower postop stay in the intervention group. CONCLUSION: VATS under non-intubated anesthesia is safe and feasible and might have advantages in terms of post-op rehabilitation
26 AGENDA Revised (8th) Edition of TNM Staging System for Lung Cancer Surgical Approaches in Localized Lung Cancer Radiation for Localized Lung Cancer
27 Radiation for Localized Lung Cancer MINI Stereotactic Body Radiation v. Observation for Early-Stage NSCLC in Elderly Patients ORAL The SPACE Study: A Randomized Phase II Trial Comparing SBRT and 3DCRT in Stage I NSCLC Patients; Final Analysis including HRQL ORAL NRG Oncology/RTOG 0813 Trial of Stereotactic Body Radiotherapy (SBRT) for Central Tumors -Adverse Events
28 MINI Do we have to treat inoperable, elderly patients?
29 No random studies of observation vs SBRT in elderly, medically inoperable patients. Retrospective study. National Cancer Data Base NSCLC treated with SBRT or no treatment, > 70 years, T1-3N0M0, Primary endpoint: OS SBRT: 258 pts No treatment: pts Med age: 79 y All patients better survival with SBRT
30 CONCLUSION: SBRT reducesa36%therelativerisk of deathin elderlypatientsvsno treatment.
31 ORAL 19.01
32 Jan 2007-Jul 2011 N: 102 ( 49 SBRT, 53 DCRT) Follow up 37 months
33
34 CONCLUSIONS: SBRT has numerically less toxicity, better QoL, improved DCR.
35 ORAL19.03
36 INTRODUCTION SBRT is used for inoperablepatients with peripheral tumors. High toxicity observed for central tumors. Phase I/II trial Primary objective: To determine MTD of SBRT for centrally-located NSCLC and the tumor control rate at the MTD. METHODS: N: 120 pts HerearereportedAEsobservedin thetrial DLT andmtd submittedto ASTRO 2015
37 4 G5 toxicity: hemoptysisoccurringat 13 m post SBRT (range m) AlthoughSBRT waswelltolerated, 4/100 ptshadfatal hemoptysisattributableto SBRT. Verypreliminarydata
38 TAKE HOME MESSAGES Revised (8th) Editionof TNM More relevance to tumor size & reclassification of some T descriptors Acknowledgement of relevance of quantification of nodal disease Three metastatic groups More stages for better prognostic stratification Operable patients: For patients with small screen-diagnosed NSCLC it is reasonable not to perform lymph node sampling, particularly in subsolidnodules. VATS under non-intubated anesthesia is safe and feasible and might have advantages in terms of post-op rehabilitation
39 TAKE HOME MESSAGES Operable patients: Patientsnotsuitable for lobectomy: Segmentectomy should be thepreferred sublobar resectionforct1an0 NSCLC. Salvagesurgeryforlocal recurrenceafterlungsbrt is feasiblewithoutmajorcomplications. Inoperable patients: SBRT in elderly, medicallyinoperable patientsseemsbetter thanobservationin ct1-3n0m0 tumors. In NSCLC T1-2 < 6cm SBRT presents numericallyless toxicity, betterqol, improved DCR (Phase II). Notreadyfor SBRT in central NSCLC tumors.
40 Dra Marga Majem Hospital de la Santa Creu i Sant Pau
A Practical Guide to Advances in Staging and Treatment of NSCLC
A Practical Guide to Advances in Staging and Treatment of NSCLC Robert J. Korst, M.D. Director, Thoracic Surgery Medical Director, The Blumenthal Cancer Center The Valley Hospital Objectives Revised staging
CANCER PULMON: ESTADIOS INICIALES POSTMUNDIAL PULMON DENVER 2015. 8-10-2015.Manuel Cobo Dols S. Oncología Médica HU Málaga Regional y VV
CANCER PULMON: ESTADIOS INICIALES POSTMUNDIAL PULMON DENVER 2015 8-10-2015.Manuel Cobo Dols S. Oncología Médica HU Málaga Regional y VV Meta-analisis LACE: adyuvancia vs no adyuvancia Pignon JP, et al.
Lung Cancer Treatment Guidelines
Updated June 2014 Derived and updated by consensus of members of the Providence Thoracic Oncology Program with the aid of evidence-based National Comprehensive Cancer Network (NCCN) national guidelines,
Alternatives to Surgical Resection for Early Stage Lung Cancer
Alternatives to Surgical Resection for Early Stage Lung Cancer Neil A. Christie MD University of Pittsburgh Medical Center Department of Thoracic Surgery Allied Health Personnel Symposium AATS 2014 Conflicts
Survival analysis of 220 patients with completely resected stage II non small cell lung cancer
窑 Original Article 窑 Chinese Journal of Cancer Survival analysis of 22 patients with completely resected stage II non small cell lung cancer Yun Dai,2,3, Xiao Dong Su,2,3, Hao Long,2,3, Peng Lin,2,3, Jian
Table of Contents. Data Supplement 1: Summary of ASTRO Guideline Statements. Data Supplement 2: Definition of Terms
Definitive and Adjuvant Radiotherapy in Locally Advanced Non-Small-Cell Lung Cancer: American Society of Clinical Oncology Clinical Practice Guideline Endorsement of the American Society for Radiation
The New International Staging System Lung Cancer
The New International Staging System Lung Cancer Valerie W. Rusch, MD Chief, Thoracic Surgery Memorial Sloan-Kettering Cancer Center Chair, Lung and Esophagus Task Force, American Joint Commission on Cancer
Extrapleural Pneumonectomy for Malignant Mesothelioma: Pro. Joon H. Lee 9/17/2012
Extrapleural Pneumonectomy for Malignant Mesothelioma: Pro Joon H. Lee 9/17/2012 Malignant Pleural Mesothelioma (Epidemiology) Incidence: 7/mil (Japan) to 40/mil (Australia) Attributed secondary to asbestos
Stage I Non-Small Cell Lung Cancer: Recurrence Patterns, Prognostic Factors and Survival
16 Stage I Non-Small Cell Lung Cancer: Recurrence Patterns, Prognostic Factors and Survival Jung-Jyh Hung and Yu-Chung Wu Division of Thoracic Surgery, Department of Surgery, Taipei Veterans General Hospital
Radiation Therapy in the Treatment of
Lung Cancer Radiation Therapy in the Treatment of Lung Cancer JMAJ 46(12): 537 541, 2003 Kazushige HAYAKAWA Professor and Chairman, Department of Radiology, Kitasato University School of Medicine Abstract:
Moving forward, where are we with Clinical Trials?
Moving forward, where are we with Clinical Trials? Dennis A. Wigle Division of Thoracic Surgery Mayo Clinic AATS/STS General Thoracic Surgery Symposium Sunday, April 27 th 2014 2012 MFMER slide-1 Where
Stomach (Gastric) Cancer. Prof. M K Mahajan ACDT & RC Bathinda
Stomach (Gastric) Cancer Prof. M K Mahajan ACDT & RC Bathinda Gastric Cancer Role of Radiation Layers of the Stomach Mucosa Submucosa Muscularis Serosa Stomach and Regional Lymph Nodes Stomach and Regional
Definitive Treatment of Poor-Risk Patients with Stage I Lung Cancer. A Single Institution Experience
ORIGINAL ARTICLE Definitive Treatment of Poor-Risk Patients with Stage I Lung Cancer A Single Institution Experience Michael Hsie, MD,* Stefania Morbidini-Gaffney, MD,* Leslie J. Kohman, MD, Elisabeth
Kidney Cancer OVERVIEW
Kidney Cancer OVERVIEW Kidney cancer is the third most common genitourinary cancer in adults. There are approximately 54,000 new cancer cases each year in the United States, and the incidence of kidney
GUIDELINES FOR THE MANAGEMENT OF LUNG CANCER
GUIDELINES FOR THE MANAGEMENT OF LUNG CANCER BY Ali Shamseddine, MD (Coordinator); as04@aub.edu.lb Fady Geara, MD Bassem Shabb, MD Ghassan Jamaleddine, MD CLINICAL PRACTICE GUIDELINES FOR THE TREATMENT
7. Prostate cancer in PSA relapse
7. Prostate cancer in PSA relapse A patient with prostate cancer in PSA relapse is one who, having received a primary treatment with intent to cure, has a raised PSA (prostate-specific antigen) level defined
Post-recurrence survival in completely resected stage I non-small cell lung cancer with local recurrence
Post- survival in completely resected stage I non-small cell lung cancer with local J-J Hung, 1,2,3 W-H Hsu, 3 C-C Hsieh, 3 B-S Huang, 3 M-H Huang, 3 J-S Liu, 2 Y-C Wu 3 See Editorial, p 185 c A supplementary
Targeted Therapy What the Surgeon Needs to Know
Targeted Therapy What the Surgeon Needs to Know AATS Focus in Thoracic Surgery 2014 David R. Jones, M.D. Professor & Chief, Thoracic Surgery Memorial Sloan Kettering Cancer Center I have no disclosures
SUNY DOWNSTATE MEDICAL CENTER SURGERY GRAND ROUNDS February 28, 2013 VERENA LIU, MD ROSEANNA LEE, MD
SUNY DOWNSTATE MEDICAL CENTER SURGERY GRAND ROUNDS February 28, 2013 VERENA LIU, MD ROSEANNA LEE, MD Case Presentation 35 year old male referred from PMD with an asymptomatic palpable right neck mass PMH/PSH:
The Need for Accurate Lung Cancer Staging
The Need for Accurate Lung Cancer Staging Peter Baik, DO Thoracic Surgery Cancer Treatment Centers of America Oklahoma Osteopathic Association 115th Annual Convention Financial Disclosures: None 2 Objectives
Chapter 2 Staging of Breast Cancer
Chapter 2 Staging of Breast Cancer Zeynep Ozsaran and Senem Demirci Alanyalı 2.1 Introduction Five decades ago, Denoix et al. proposed classification system (tumor node metastasis [TNM]) based on the dissemination
Adjuvant Therapy Non Small Cell Lung Cancer. Sunil Nagpal MD Director, Thoracic Oncology Jan 30, 2015
Adjuvant Therapy Non Small Cell Lung Cancer Sunil Nagpal MD Director, Thoracic Oncology Jan 30, 2015 No Disclosures Number of studies Studies Per Month 12 10 8 6 4 2 0 1 2 3 4 5 6 7 8 9 10 11 12 1 2 3
Corso Integrato di Clinica Medica ONCOLOGIA MEDICA AA 2010-2011 LUNG CANCER. IV. THERAPY. I. NON SMALL CELL LUNG CANCER Prof.
Corso Integrato di Clinica Medica ONCOLOGIA MEDICA AA 2010-2011 LUNG CANCER. IV. THERAPY. I. NON SMALL CELL LUNG CANCER Prof. Alberto Riccardi TREATMENT OF LUNG CARCINOMA * overall treatment approach to
Lung cancer forms in tissues of the lung, usually in the cells lining air passages.
Scan for mobile link. Lung Cancer Lung cancer usually forms in the tissue cells lining the air passages within the lungs. The two main types are small-cell lung cancer (usually found in cigarette smokers)
How To Know When To Stage Lung Cancer
WHITE PAPER - SBRT for Non Small Cell Lung Cancer I. Introduction This white paper will focus on non-small cell lung carcinoma with sections one though six comprising a general review of lung cancer from
SMALL CELL LUNG CANCER
Protocol for Planning and Treatment The process to be followed in the management of: SMALL CELL LUNG CANCER Patient information given at each stage following agreed information pathway 1. DIAGNOSIS New
Carcinoma of the Cervix. Kathleen M. Schmeler, MD Associate Professor Department of Gynecologic Oncology
Carcinoma of the Cervix Kathleen M. Schmeler, MD Associate Professor Department of Gynecologic Oncology Cervical Cancer Treatment Treatment Microinvasive (Stage IA1): Simple (extrafascial) hysterectomy/cone
Probe: Could you tell me about when?
PERIODIC ASSESSMENT OF TREATMENT AND VITAL/DISEASE STATUS Periodic Assessment of Cancer Treatment and Disease Status (To be administered to patient at 3 months and reviewed at 6, 9 and 12 months) Instructions:
Integrating Chemotherapy and Liver Surgery for the Management of Colorectal Metastases
I Congresso de Oncologia D Or July 5-6, 2013 Integrating Chemotherapy and Liver Surgery for the Management of Colorectal Metastases Michael A. Choti, MD, MBA, FACS Department of Surgery Johns Hopkins University
Understanding Your Surgical Options for Lung Cancer
Information Booklet for Patients Understanding Your Surgical Options for Lung Cancer Understanding Lung Cancer If you have just been diagnosed with lung cancer, this booklet will serve as an informational
Objectives. Mylene T. Truong, MD. Malignant Pleural Mesothelioma Background
Imaging of Pleural Tumors Mylene T. Truong, MD Imaging of Pleural Tumours Mylene T. Truong, M. D. University of Texas M.D. Anderson Cancer Center, Houston, TX Objectives To review tumors involving the
Radioterapia panencefalica. Umberto Ricardi
Radioterapia panencefalica Umberto Ricardi Background Systemic disease to the brain is unfortunately a quite common event Radiotherapy, especially with the great technical development during the past decades,
Prognostic stratification of patients with T3N1M0 non-small cell lung cancer: which phase should it be?
DOI 10.1007/s12032-011-9907-y ORIGINAL PAPER Prognostic stratification of patients with T3N1M0 non-small cell lung cancer: which phase should it be? Ali Kilicgun Ozgur Tanriverdi Akif Turna Muzaffer Metin
Epidemiology, Staging and Treatment of Lung Cancer. Mark A. Socinski, MD
Epidemiology, Staging and Treatment of Lung Cancer Mark A. Socinski, MD Associate Professor of Medicine Multidisciplinary Thoracic Oncology Program Lineberger Comprehensive Cancer Center University of
Sentinel Lymph Node Mapping for Endometrial Cancer. Locke Uppendahl, MD Grand Rounds
Sentinel Lymph Node Mapping for Endometrial Cancer Locke Uppendahl, MD Grand Rounds Endometrial Cancer Most common gynecologic malignancy in US estimated 52,630 new cases in 2014 estimated 8,590 deaths
Finding an Appropriate Treatment
Focus on CME at the University of Toronto Early Detected Lung Cancer: Finding an Appropriate Treatment Thanks to modern technology, subcentimeter tumors are now being identified. As with other malignant
Treatment Algorithms for the Management of Lung Cancer in NSW Guide for Clinicians
Treatment Algorithms for the Management of Lung Cancer in NSW Guide for Clinicians Background The Cancer Institute New South Wales Oncology Group Lung (NSWOG Lung) identified the need for the development
Lung Cancer and Mesothelioma
Lung Cancer and Mesothelioma Robert Kratzke, M.D. John C. Skoglund Professor of Lung Cancer Research Section of Heme/Onc/Transplant Department of Medicine University of Minnesota Medical School Malignant
An Overview of Lung Cancer Symptoms, Pathophysiology, And Treatment Linda H. Yoder
CE Objectives and Evaluation Form appear on page 235. An Overview of Lung Cancer Symptoms, Pathophysiology, And Treatment Linda H. Yoder Patients with lung cancer can provide treatment challenges for even
Accelerated hemithoracic radiation followed by extrapleural pneumonectomy for malignant pleural mesothelioma
Accelerated hemithoracic radiation followed by extrapleural pneumonectomy for malignant pleural mesothelioma Marc de Perrot, Ronald Feld, Natasha B Leighl, Andrew Hope, Thomas K Waddell, Shaf Keshavjee,
Thoracic surgery in Norway 2014 Norwegian Association for Cardiothoracic Surgery
Thoracic surgery in Norway 214 Norwegian register for general thoracic surgery. Steinar Solberg, MD, PhD. Department of Thoracic and Cardiovascular Surgery Rikshospitalet, Norway steinar.solberg@rikshospitalet.no
INTERNATIONAL ASSOCIATION FOR THE STUDY OF LUNG CANCER Prospective Mesothelioma Staging Project
INTERNATIONAL ASSOCIATION FOR THE STUDY OF LUNG CANCER Prospective Mesothelioma Staging Project Data Forms and Fields in CRAB Electronic Data Capture System - Reduced Set - Pivotal data elements for developing
ROLE OF RADIATION THERAPY FOR RESECTABLE LUNG CANCER
AFA 08958 From Bench to Bedside From KK DT1 10/27/2015 12:04 PM 01 ROLE OF RADIATION THERAPY FOR RESECTABLE LUNG CANCER Hak Choy, MD University of Texas Southwestern Medical Center Dallas, Texas, USA Orchestrating
Implementation Date: April 2015 Clinical Operations
National Imaging Associates, Inc. Clinical guideline PROSTATE CANCER Original Date: March 2011 Page 1 of 5 Radiation Oncology Last Review Date: March 2015 Guideline Number: NIA_CG_124 Last Revised Date:
Detection and staging of recurrent prostate cancer is still one of the important clinical problems in prostate cancer. A rise in PSA or biochemical
Summary. 111 Detection and staging of recurrent prostate cancer is still one of the important clinical problems in prostate cancer. A rise in PSA or biochemical recurrence (BCR) is the first sign of recurrent
Management of low grade glioma s: update on recent trials
Management of low grade glioma s: update on recent trials M.J. van den Bent The Brain Tumor Center at Erasmus MC Cancer Center Rotterdam, the Netherlands Low grades Female, born 1976 1 st seizure 2005,
PET/CT in Lung Cancer
PET/CT in Lung Cancer Rodolfo Núñez Miller, M.D. Nuclear Medicine and Diagnostic Imaging Section Division of Human Health International Atomic Energy Agency Vienna, Austria GLOBOCAN 2012 #1 #3 FDG-PET/CT
A Decade of Advances in Treatment of Early- Stage Lung Cancer
A Decade of Advances in Treatment of Early- Stage Lung Cancer Luca Paoletti, MD a, Nicholas J. Pastis, MD a, Chadrick E. Denlinger, MD b, Gerard A. Silvestri, MD, MS a, * KEYWORDS Lung cancer Treatment
Protein kinase C alpha expression and resistance to neo-adjuvant gemcitabine-containing chemotherapy in non-small cell lung cancer
Protein kinase C alpha expression and resistance to neo-adjuvant gemcitabine-containing chemotherapy in non-small cell lung cancer Dan Vogl Lay Abstract Early stage non-small cell lung cancer can be cured
Current Status and Perspectives of Radiation Therapy for Breast Cancer
Breast Cancer Current Status and Perspectives of Radiation Therapy for Breast Cancer JMAJ 45(10): 434 439, 2002 Masahiro HIRAOKA, Masaki KOKUBO, Chikako YAMAMOTO and Michihide MITSUMORI Department of Therapeutic
Evidence tabel Lokaal palliatieve behandelingen
Auteurs, jaartal Mate van bewijs Studie type Follow-up Populatie (incl. steekproef-grootte) Patienten kenmerken Interventie Controle Resultaten Conclusie Opmerkingen, commentaar Hartgrink, 2002 The Netherlands
Radiotherapy in locally advanced & metastatic NSC lung cancer
Radiotherapy in locally advanced & metastatic NSC lung cancer Dr Raj Hegde. MD. FRANZCR Consultant Radiation Oncologist. William Buckland Radiotherapy Centre. Latrobe Regional Hospital. Locally advanced
B. Dingle MD, FRCPC, Brian Yaremko MD,FRCPC, R. Ash, MD, FRCPC, P. Truong, MD, FRCPC
Lung Cancer B. Dingle MD, FRCPC, Brian Yaremko MD,FRCPC, R. Ash, MD, FRCPC, P. Truong, MD, FRCPC EPIDEMIOLOGY The estimated incidence of lung cancer in Canada for 2007 is 23,300 with 12,400 occurring in
Lung Cancer Treatment
Scan for mobile link. Lung Cancer Treatment Lung cancer overview More than one in four of all diagnosed cancers involve the lung, and lung cancer remains the most common cancer-related cause of death among
Image. 3.11.3 SW Review the anatomy of the EAC and how this plays a role in the spread of tumors.
Neoplasms of the Ear and Lateral Skull Base Image 3.11.1 SW What are the three most common neoplasms of the auricle? 3.11.2 SW What are the four most common neoplasms of the external auditory canal (EAC)
NCCN Non-Small Cell Lung Cancer V.1.2011 Update Meeting 07/09/10
Guideline Page and Request NSCL-3 Stage IA, margins positive delete the recommendation for chemoradiation. Stage IB, IIA, margins positive delete the recommendation for chemoradiation + Stage IIA, Stage
Surgical Outcomes in Resected Non-small Cell Lung Cancer 1 cm in Diameter
ORIGINAL ARTICLE Surgical Outcomes in Resected Non-small Cell Lung Cancer 1 cm in Diameter Bing-Yen Wang 1, Jung-Jyh Hung 1,2,3, Wen-Juei Jeng 4, Wen-Hu Hsu 1, Chih-Cheng Hsieh 1, Min-Hsiung Huang 1, Biing-Shiun
An Update on Lung Cancer Diagnosis
An Update on Lung Cancer Diagnosis Dr Michael Fanning MBBS FRACGP FRACP RESPIRATORY AND SLEEP PHYSICIAN Mater Medical Centre Outline Risk factors for lung cancer Screening for lung cancer Radiologic follow-up
How To Treat Lung Cancer At Cleveland Clinic
Treatment Guide Lung Cancer Management The Chest Cancer Center at Cleveland Clinic, which includes specialists from the Respiratory Institute, Taussig Cancer Institute and Miller Family Heart & Vascular
TITLE: Minimal Access Lobectomy for Lung Cancer Patients: A Review of the Clinical and Cost-Effectiveness
TITLE: Minimal Access Lobectomy for Lung Cancer Patients: A Review of the Clinical and Cost-Effectiveness DATE: 02 February 2009 CONTEXT AND POLICY ISSUES: In Canada, lung cancer is the most common type
Although many reports on the prognostic factors of non small cell
Carbone et al T2 tumors larger than five centimeters in diameter can be upgraded to T3 in non small cell lung cancer Emanuela Carbone, MD a,b Hisao Asamura, MD a Hidefumi Takei, MD a Haruhiko Kondo, MD
How To Compare The Effects Of A Hysterectomy And A Hysterectomy
A RANDOMIZED TRIAL COMPARING RADICAL HYSTERECTOMY AND PELVIC NODE DISSECTION VS SIMPLE HYSTERECTOMY AND PELVIC NODE DISSECTION IN PATIENTS WITH LOW RISK EARLY STAGE CERVICAL CANCER A Gynecologic Cancer
Early Stage Non-Small-Cell Lung Cancer EVIDENCE TABLE
1. Hansen H. Introduction. In: Hansen H, ed. In Lung Cancer Therapy Annual. 6th ed. New York: Informa Health Care; 009:1-6.. Siegel R, Naishadham D, Jemal A. Cancer statistics, 01. CA Cancer J Clin 01;
The National Clinical Lung Cancer Audit (LUCADA)
The National Clinical Lung Cancer Audit (LUCADA) DATA MANUAL Title: Version: 3.1.5 Date: September 2013 LUCADA Lung Cancer Audit VERSION HISTORY Version Date Issued Brief Summary of Change Owner s Name
Radiotherapy for Non-Small Cell Lung Cancer. Standard Treatment Options Radiotherapy Planning
Radiotherapy for Non-Small Cell Lung Cancer I II Standard Treatment Options Radiotherapy Planning TNM Staging System Disease Staging - Management is based on disease stage - Stage I-II: early stage - Stage
RESEARCH EDUCATE ADVOCATE. Just Diagnosed with Melanoma Now What?
RESEARCH EDUCATE ADVOCATE Just Diagnosed with Melanoma Now What? INTRODUCTION If you are reading this, you have undergone a biopsy (either of a skin lesion or a lymph node) or have had other tests in which
New Trends & Current Research in the Treatment of Lung Cancer, Pt. II
New Trends & Current esearch in the Treatment of Lung Cancer, Pt. II Howard (Jack) West, MD President & CEO, GACE Medical Director, Thoracic Oncology Program Swedish Cancer Institute Seattle, WA Cancer
How To Treat A Uterine Sarcoma
EVERYONE S GUIDE FOR CANCER THERAPY Malin Dollinger, MD, Ernest H. Rosenbaum, MD, Margaret Tempero, MD, and Sean Mulvihill, MD 4 th Edition 2001 Uterus: Uterine Sarcomas Jeffrey L. Stern, MD Uterine sarcomas
The Di Bella Method (DBM) improves Survival, Objective Response and Performance Status in Breast Cancer
BIT's 4th World Cancer Congress 2011 People s Republic of China Dalian The Di Bella Method (DBM) improves Survival, Objective Response and Performance Status in treated with DBM therapy Retrospective observational
General Information About Non-Small Cell Lung Cancer
General Information About Non-Small Cell Lung Cancer Non-small cell lung cancer is a disease in which malignant (cancer) cells form in the tissues of the lung. The lungs are a pair of cone-shaped breathing
Non-Small Cell Lung Cancer Treatment Comparison to NCCN Guidelines
Non-Small Cell Lung Cancer Treatment Comparison to NCCN Guidelines April 2008 (presented at 6/12/08 cancer committee meeting) By Shelly Smits, RHIT, CCS, CTR Conclusions by Dr. Ian Thompson, MD Dr. James
Staging Head and Neck Cancers Transitioning to the Seventh Edition of The AJCC Cancer Staging Manual
Staging Head and Neck Cancers Transitioning to the Seventh Edition of The AJCC Cancer Staging Manual Jatin P. Shah, MD, PhD (Hon) Memorial Sloan-Kettering Cancer Center New York, New York The American
SAKK Lung Cancer Group. Current activities and future projects
SAKK Lung Cancer Group Current activities and future projects SAKK Lung Cancer Group Open group of physicians interested in lung cancer Mostly Medical Oncologists, but also Thoracic Surgeons Radiation
Prognostic and Predictive Factors in Oncology. Mustafa Benekli, M.D.
Prognostic and Predictive Factors in Oncology Mustafa Benekli, M.D. NCI Definitions ESMO Course -Essentials of Medical Oncology -Istanbul 2 Prognostic factor: NCI Definition A situation or condition, or
These rare variants often act aggressively and may respond differently to therapy than the more common prostate adenocarcinoma.
Prostate Cancer OVERVIEW Prostate cancer is the second most common cancer diagnosed among American men, accounting for nearly 200,000 new cancer cases in the United States each year. Greater than 65% of
Clinical Indications and Results Following Chest Wall Resection
Clinical Indications and Results Following Chest Wall Resection for Recurrent Malignant Pleural Mesothelioma Ali SO, Burt BM, Groth SS, DaSilva MC, Yeap BY, Richards WG, Baldini EH and Sugarbaker DJ. Division
Management of Peritoneal Metastases (PM) from colorectal cancers: New Perspectives. Dominique ELIAS
Management of Peritoneal Metastases (PM) from colorectal cancers: New Perspectives Dominique ELIAS Declaration of interest BOARDS Congress and teaching 0 Merck 0 Ipsen Novartis Sanofi Trials The peritoneum
Non-Small Cell Lung Cancer
Non-Small Cell Lung Cancer John delcharco, MD (Statistics based on CVMC data 2009-2013) Statistics Lung cancer is the leading cause of cancer deaths in the United States. The American Cancer Society estimates
TRATTAMENTO COMBINATO RADIO- CHEMIOTERAPICO NEL III STADIO NSCLC
TRATTAMENTO COMBINATO RADIO- CHEMIOTERAPICO NEL III STADIO NSCLC Dr.ssa Sara Ramella Radioterapia Oncologica Campus Bio-Medico Trimodality therapy offers a promising chance of long-term survival Evidenze
Management of Stage III, N2 NSCLC: A Virtual Thoracic Oncology Tumor Board
Management of Stage III, N2 NSCLC: A Virtual Thoracic Oncology Tumor Board Abstract Introduction Management of stage III non small-cell lung cancer (NSCLC) is complex and requires careful work-up, staging,
a commitment in their practice to the roles and responsibilities of clinical oncologists X
CLINICAL ONCOLOGY BLUEPRINT OF ASSESSMENT SYSTEM Good Medical Practice areas of curriculum - ST5 (Intermediate) Standards GMP criterion Workplace based assessment By the end of the third year of training
Individual Prediction
Individual Prediction Michael W. Kattan, Ph.D. Professor of Medicine, Epidemiology and Biostatistics, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University Chairman, Department
Corso Integrato di Clinica Medica ONCOLOGIA MEDICA AA 2010-2011 LUNG CANCER. VIII. THERAPY. V. SMALL CELL LUNG CANCER Prof.
Corso Integrato di Clinica Medica ONCOLOGIA MEDICA AA 2010-2011 LUNG CANCER. VIII. THERAPY. V. SMALL CELL LUNG CANCER Prof. Alberto Riccardi SMALL CELL LUNG CARCINOMA Summary of treatment approach * limited
Lung Cancer: Diagnosis, Staging and Treatment
PATIENT EDUCATION patienteducation.osumc.edu Lung Cancer: Diagnosis, Staging and Treatment Cancer begins in our cells. Cells are the building blocks of our tissues. Tissues make up the organs of the body.
Lungenkrebs. Lungenkrebs Häufigkeit
Lungenkrebs Prof. Dr. E.W. Russi Pneumologie 1.9.2008 Lungenkrebs Häufigkeit The Principles and Practice of Medicine William Osler New York D. Appleton and Company 1892 Section IV DISEASE OF THE RESPIRATORY
Non-small cell lung cancer, advanced or metastatic, switch-therapy after gemcitabine/carboplatin
COMPENDIA TRANSPARENCY TRACKING FORM DRUG: Docetaxel INDICATION: Non-small cell lung cancer, advanced or metastatic, switch-therapy after gemcitabine/carboplatin COMPENDIA TRANSPARENCY REQUIREMENTS 1 Provide
Invasive Cervical Cancer. Kathleen M. Schmeler, MD Associate Professor Department of Gynecologic Oncology
Invasive Cervical Cancer Kathleen M. Schmeler, MD Associate Professor Department of Gynecologic Oncology Cervical Cancer Etiology Human Papilloma Virus (HPV): Detected in 99.7% of cervical cancers Cancer
Does my patient need more therapy after prostate cancer surgery?
Does my patient need more therapy after prostate cancer surgery? Contact the GenomeDx Patient Care Team at: 1.888.792.1601 (toll-free) or e-mail: client.service@genomedx.com Prostate Cancer Classifier
Management of Postmenopausal Women with T1 ER+ Tumors: Options and Tradeoffs. Case Study. Surgery. Lumpectomy and Radiation
Management of Postmenopausal Women with T1 ER+ Tumors: Options and Tradeoffs Michael Alvarado, MD Associate Professor of Surgery University of California San Francisco Case Study 59 yo woman with new palpable
Lung Cancer: An Overview
VOL. I Issue 2 2010 Lung Cancer: An Overview By Matthew F. Koscielski, M.D. Lung cancer is the most common cause of cancer mortality worldwide. In the United States there are about 220,000 new cases of
Rotation Specific Goals & Objectives: University Health Network-Princess Margaret Hospital/ Sunnybrook Breast/Melanoma
Rotation Specific Goals & Objectives: University Health Network-Princess Margaret Hospital/ Sunnybrook Breast/Melanoma Medical Expert: Breast Rotation Specific Competencies/Objectives 1.0 Medical History
Temporal Trends in Demographics and Overall Survival of Non Small-Cell Lung Cancer Patients at Moffitt Cancer Center From 1986 to 2008
Special Report Temporal Trends in Demographics and Overall Survival of Non Small-Cell Lung Cancer Patients at Moffitt Cancer Center From 1986 to 2008 Matthew B. Schabath, PhD, Zachary J. Thompson, PhD,
The Role of Laparoscopy in Endometrial Cancer
The Role of Laparoscopy in Endometrial Cancer Prof. Dr. Tugan BEŞE İstanbul University, Cerrahpaşa Medical Faculty Gynecologic Oncology Department Surgical staging in Endometrial Cancer Laparoscopic surgery
Prostatectomy, pelvic lymphadenect. Med age 63 years Mean followup 53 months No other cancer related therapy before recurrence. Negative.
Adjuvante und Salvage Radiotherapie Ludwig Plasswilm Klinik für Radio-Onkologie, KSSG CANCER CONTROL WITH RADICAL PROSTATECTOMY ALONE IN 1,000 CONSECUTIVE PATIENTS 1983 1998 Clinical stage T1 and T2 Mean
oracic Oncology Advances
Winter 2011 oracic Oncology Advances Page 2 Page 4 Page 6 Page 7 Innovative Clinical Trials and Research Expand Targeted Medical Therapies and Personalized Approaches to Lung Cancer Care Medical oncologists
Metastatic Renal Cell Carcinoma: Staging and Prognosis of Three Separate Cases.
Metastatic Renal Cell Carcinoma: Staging and Prognosis of Three Separate Cases. Abstract This paper describes the staging, imaging, treatment, and prognosis of renal cell carcinoma. Three case studies
Radiocirugía y radioterapia estereotáxica corporal
Radiocirugía y radioterapia estereotáxica corporal Eficacia, seguridad y eficiencia en cáncer de pulmón primario y oligometastásis pulmonares Radiosurgery and stereotactic body radiation therapy. Efficacy,
L Lang-Lazdunski, A Bille, S Marshall, R Lal, D Landau, J Spicer
Pleurectomy/decortication, hyperthermic pleural lavage with povidone-iodine and systemic chemotherapy in malignant pleural mesothelioma. A 10-year experience. L Lang-Lazdunski, A Bille, S Marshall, R Lal,
Effective Health Care Program
Comparative Effectiveness Review Number 152 Effective Health Care Program Treatment of Nonmetastatic Muscle-Invasive Bladder Cancer Executive Summary Background Nature and Burden of Nonmetastatic Muscle-Invasive