2011 Annual Report T H E NANOTECHNOLOGY I N S T I T U T E

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1 2011 Annual Report T H E NANOTECHNOLOGY TM I N S T I T U T E

2 The Nanotechnology Institute The Nanotechnology Institute (NTI) is southeastern Pennsylvania s first multi-institutional partnership created to accelerate nanotechnology research, commercialization and company formation. This technology powerhouse was created in 2000 by Ben Franklin Technology Partners of Southeastern Pennsylvania (BFTP/SEP), Drexel University and the University of Pennsylvania. Today, NTI accelerates regional economic development by connecting industry with university assets through its thirteen member research institutions. The NTI receives funding from Pennsylvania s Ben Franklin Technology Development Authority. The Pennsylvania Department of Community In 2011, the NTI was awarded an Honorable Mention at the and Economic Development (DCED) s International Economic Development Council s Excellence in Technology Investment Office looks to NTI as a valued partner in harnessing the technology Economic Development Awards, in the category of Partnerships based economic development opportunities with Educational Institutions. within PA s nanotechnology community. A review of the NTI is being published in the Nanotechnology Law - Secretary C. Alan Walker, DCED & Business Journal. ACCOMPLISHMENTS $255M Leveraged 740 IP Assets Managed 132 Jobs Created 31 Companies Created 43 Businesses Assisted 48 Technology Licenses 116 Projects $16.3M Deployed There are thirteen member research institutions within the NTI framework: Children s Hospital of Philadelphia Drexel University Fox Chase Cancer Center Harrisburg University of Science & Technology Lankenau Institute for Medical Research Lehigh University Millersville University Philadelphia University Temple University University of Pennsylvania University of the Sciences in Philadelphia Villanova University Widener University

3 Arterial Magnetic Targeting Device Chorny/Levy, CHOP NanoJacket Structure Keystone Nano Carbon Nanopipettes H. Bau/U Penn Graphene Flexing R.W. Carpick, U. Pennsylvania NTI created the Nanotechnology Commercialization Group (NCG) to be a single point-of-contact system across the institutional partners, providing robust business development services with streamlined Intellectual Property (IP) and licensing processes. NCG pools intellectual property from participating institutions, providing a community technology transfer service with expertise to promote nanotechnology commercialization. Programs: The Program to Support Translational Research Fund (PSTR) fuels the research of commercially feasible technology recommended by the NCG to move from concept into enterprise development. Funding consideration is based on assessment of commercial potential, patent protection, and the ability of the funded studies to add significant value to the technology. Sponsored Research Agreements (SRAs) are an important and widely used mechanism for industry sponsorship of directed research in university laboratories. In this type of arrangement, one or more companies fund a university researcher or research team to conduct a specific project with defined objectives of interest to the companies. Typically, SRAs are used to perform specific tasks on known potential products or developing technologies. The NTI plays a vital role by matching the development needs of its corporate members to university laboratories, and providing matching funds to accelerate the development. The NanoApplications Fund (NAF) accelerates technology development for small companies by facilitating and funding research and development partnerships between smaller companies and NTI member research institutions. NTI Management Oversight: Steven J. Fluharty, Ph.D., Senior Vice Provost for Research; Professor of Pharmacology, Psychology and Neuroscience, University of Pennsylvania Deborah Crawford, Ph.D., Senior Vice Provost for Research, Drexel University RoseAnn B. Rosenthal, President and Chief Executive Officer, Ben Franklin Technology Partners of Southeastern Pennsylvania Operations: Anthony P. Green, Ph.D., Ben Franklin Director, NTI; Vice President of Technology Commercialization: Life Sciences, Ben Franklin Technology Partners of Southeastern Pennsylvania Karen I. Winey, Ph.D., Principal Investigator, NTI; Professor, Department of Materials Science & Engineering, University of Pennsylvania Michele S. Marcolongo, Ph.D., Principal Investigator, NTI; Senior Associate Vice Provost for Translational Research; Professor of Materials Science & Engineering, Drexel University Erli Chen, Ph.D., Director, Nanotechnology Commercialization Group, NTI; Director of Nanotechnology Licensing, Center for Technology Transfer, University of Pennsylvania

4 FUNDED PROJECTS TECHNOLOGY SECTOR PROJECT Life Sciences NanoMaterials Probes Sensors Delivery BioMaterials Materials Energy/ Water Carbon Nanopipettes with Metal-coated Tips. University of Pennsylvania Bio Sensor Array Based on Resonant Nano-Channels. University of Pennsylvania Surface-Enhanced Raman Scattering Substrate Filters for Detection of Air-Borne Toxins. Drexel University Nanoconjugates for Targeted Treatment of Acute Lung Injury. Temple University Vascular Magnetic Intervention with a Temporary Magnetic Targeting Device. Children s Hospital of Philadelphia Controlling Molecular Interactions on Biomedical Substrates for Selective Protein Adsorption. University of Pennsylvania Optimization of Fabrication Process for Novel Bioactive Glass Scaffolds. Lehigh University Polymer-Nanoparticle Composite Conducting Thin Films. University of Pennsylvania Low-Cost, Scalable and Ecologically-Friendly Growth of Earth-Abundant Oxide Electronic Materials. Drexel University Low-Temperature Mechanical Reinforcement of Nanoparticle Thin Films. University of Pennsylvania Improving Nanoscale Surface Properties of Polyolefin and Polyolefi n Nanocomposites. University of Pennsylvania Solventless Particle Encapsulation via Initiated Chemical Vapor Deposition. Drexel University Inhibiting Oxidation of Metal Sulfi de-containing Material Using Nano-Bilayers of Phospholipids. Temple University Frac Water Analysis. Drexel University Nano-Enhanced Plastic-Based Cementitious Material. Temple University TM Building 100 Innovation Center 4801 S. Broad St, Suite 200 The Navy Yard Philadelphia, PA [T] [F] [email protected] The NTI is financed by a grant from the Commonwealth of Pennsylvania, Ben Franklin Technology Development Authority.

5 The Nanotechnology Institute Select Client Companies Keystone Nano is developing nanoscale solutions for better treatment of cancer, and for improvements in difficult-to-solve industrial chemistries. Their lead product is a nano particle package for a leading cancer drug. Leversense is commercializing an innovative new method for in vitro diagnostics technology. The technology, licensed from Drexel University, is a solid-state electromechanical sensor technology used to detect protein, nucleic acid and pathogen disease indicators. Ben Franklin Technology Partners of Southeastern PA has also invested $500,000 in the company. Structured Materials Industries is focused on being the leader in custom research and production Metal Organic Chemical Vapor Deposition (MOCVD) Technology used to create LED lights, solar panels and other complex materials. Sunstone BioSciences, Inc., a cancer treatment company, is currently developing nanoparticles as photosensitizer delivery and activation systems that will allow for preferential tumor uptake. The company s products have been licensed to a major biopharmaceutical company. Sunstone is a subsidiary of Intelligent Materials Solutions. Y-Carbon is a developer, manufacturer and supplier of a wide variety of activated carbons. The company is developing super capacitors based on tunable nanoporous carbons.