Copenhagen University Hospital, Rigshospitalet, Denmark

Transcription

1 Football training improves lean body mass in men with prostate cancer undergoing androgen deprivation therapy Jacob Uth, MHS, PT, PhD. stud. Copenhagen University Hospital, Rigshospitalet, Denmark

2 PROSTATAKRÆFT 24% af alle nye kræfttilfælde i Danmark 4400 nye tilfælde om året Relativ 5 års overlevelse 84 % Ca. 50% får kastrationsbaseret hormonel behandling Nordcan ; The Danish Cancer Registry 2012

3 HORMONMANIPULATION OG PROSTATAKRÆFT Hjerte-/karsygdom Tab af libido Impotens Nedgang i kognitiv funktion Depression Øget træthed Nedsat livskvalitet KASTRATIONSBASERET BEHANDLING Ændret krops-sammensætning og nedsat fysisk funktionsniveau Diabetes Karstivhed Osteoporose Fald Frakturer Smith et al. 2001, NEJM ; Diamond et al. 1998, Cancer; Shaninian et al. 2005, NEJM; Smith et al., 2005, JCO; Keating et al. 2006, JCO; Saigal et al. 2007, Cancer.

4 Trained elderly Men on ADT Warburton D E et al. CMAJ 2006;174: by Canadian Medical Association

5 Fodbold træning øger muskelmassen og forbedrer kondition hos raske utrænede mænd Krustrup et al. 2010

6 Uth et al. 2014, SJMSS

7 Week 1-4 Week 5-8 Week 9-12 Week Training 2x/week Training 2x/week Training 3x/week Training 2x/week 15 mins warm-up 15 mins warm-up 15 mins warm-up 15 mins warm-up 2 x 15 mins games 3 x 15 mins games 3 x 15 mins games 3 x 15 mins games Distance covered: Week 2-3: 1559 m (range m) Week 10-11: 2004 m (range m Fig. 2 Fraction of total training time (%) Wk 2-3 Wk <70% % % Heart rate zones (% of HRmax) Uth et al. 2014, SJMSS

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9 Uth et al., SJMSS 2014

10 Injury risk? Fibula fracture (#1): first training session no reported trauma neuropathia excluded from intervention Fibula fracture (#2): 16th training session trauma conservative treatment(2 mths) continued football training Partial achilles tendon rupture: 7th training session conservative treatment(2 mths) continued football training

11 FC Prostata Community (FC-PC)

12 Copenhagen University Hospital, Rigshospitalet: Mikael Rørth Julie Midtgaard Klaus Brasso Jesper Frank Christensen Ditte Marie Bruun Jacob Uth Department of Department of Nutrition, Exercise and Sports, Copenhagen University Peter Krustrup Therese Hornstrup Jakob Schmidt Eva Wulff Helge Department of Biostatistics, University of Copenhagen Karl Bang Christensen Gentofte University Hospital Peter Riis Hansen Centre of integrated rehabilitation of cancer patients - CIRE Sponsors: The Novo Nordisk Foundation, The Danish Cancer Society, Beckett Foundation, and TrygFonden 12