Product Catalogue. Products for Researchers. Antibodies. Antigens. Clinical Specimens. Manufacturing Reagents. Specialist Immunologicals
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1 Product Catalogue Products for Researchers Antibodies Antigens Clinical Specimens Manufacturing Reagents Specialist Immunologicals
2 Binding Site Binding Site is a Specialist Protein company committed to the research, development, manufacture and distribution of innovative immunodiagnostic assays for the global laboratory market. With extensive expertise in antibody specificity technology, Binding Site gives clinicians and laboratory staff the tools to significantly improve diagnosis and management of patients across a range of cancers and immune system disorders. Binding Site Offices The headquarters of The Binding Site Group Ltd is located in Birmingham, UK and employs over 400 people. In addition to research activities, the main site houses product development and manufacturing along with global distribution, marketing and administrative functions. Direct sales and product support to customers in the UK are based here together with sales and technical support provided to our distributor network in 81 countries. Quality Assurance Our manufacturing site has quality systems approved to both ISO9001 and ISO13485:2003 certification. These, together with strict adherence to rigorous internal quality control procedures, ensure customers can be confident in the quality of Binding Site products. Reducing our Impact on the Environment Binding Site s environmental policy outlines our commitment to limit the overall impact our processes have on the environment. The new 2011 head office was built with a focus on reduced energy and water consumption, has provisions for rainwater harvesting and meets strict carbon emission restrictions. All staff are trained on our Reduce, Reuse & Recycle policy. Direct Binding Site sales and support organisations are also based in: San Diego, California for USA & Canada Schwetzingen, near Heidelberg for Germany, Austria & Switzerland Grenoble for France & French speaking distributor markets Barcelona for Spain & Portugal Prague for Czech Republic & Slovak Republic Antwerp for Belgium, Netherlands & Luxembourg Bergamo, near Milan for Italy São Paulo for Latin America
3 TABLE OF CONTENTS PAGE INTRODUCTION 1 ANTIBODIES 2 Human Immunoglobulins 2 Human Complement 3 Human Coagulation Proteins 3 Human Acute Phase Proteins 3 Other Human Proteins 3 FITC Conjugated Human Immunoglobulin Antibodies 4 FITC Conjugated Human Complement/Coagulation Protein Antibodies 4 HRP Conjugated Human Immunoglobulins 4 HRP Conjugated Human Protein Antibodies 4 HRP Conjugated Monoclonal Antibodies 4 Animal Proteins 5 FITC Conjugated Antibodies to Animal Proteins 5 HRP Conjugated Antibodies to Animal Proteins 5 ANTIGENS 5 Human Purified Myeloma Antigens 5 CLINICAL SPECIMENS (USA / Germany only) 6 MANUFACTURING REAGENTS 7
4 Introduction to Immunologicals from Binding Site As a manufacturer of a wide range of innovative in vitro diagnostic products, Binding Site understands the necessity for high quality raw materials and components. With a proven track record for over a quarter of a century, our expertise in immunisation and processing techniques has led to our international recognition as a key supplier of antibodies, antigens, bulk antisera, clinical specimens and diagnostic reagents. From initial product concept through to launch, we pledge to you excellence in quality, attention to detail, and the highest in customer service. Whatever your requirements, we would welcome hearing from you and we look forward to working with you now and in the future. Our flexibility of scale from small R&D quantities to larger lots allow us to support your project whatever its size. Key elements for success lie within the way we work and the quality systems that are in place. Our commitment to continuous improvement allows us to enhance the quality of our product and service offering Working closely with researchers to ensure a focused and timely delivery of your product We are accredited to both ISO9001 and ISO13485:2003 and manufacture to GMP standards. Our internal quality systems ensure high standards, consistency, and reliability of product supply. 1 Binding Site Head office
5 Antibodies Binding Site offers a comprehensive range of antibodies focusing on human serum proteins including their subclasses. Affinity purified, IgG fraction and conjugations to Fluorescein- Isothiocyanate (FITC) and Horseradish Peroxidase (HRP) are routinely available. Additional custom formats can be made available on request. Affinity purified antibodies (product codes starting A) are purified against an immobilised antigen. In some instances, solid phase absorption is also utilised to reduce inter-species cross reactivity. IgG fraction antibodies (product codes starting P) are IgG fractions of sheep sera. Human Immunoglobulins Antibodies A wide range of human immunoglobulins are available for use in immunoassay testing methodologies. In many instances the volumes of product are unspecified to allow maximum customer choice and flexibility. Sheep Polyclonal Antibodies IgA IFE Grade Antisera Customer Specifi ed FX010 IgA IgG Fraction 1mL PC010 IgE IFE Grade Antisera Customer Specifi ed FX014 IgG IFE Grade Antisera Customer Specifi ed FX004 IgG Affinity Purifi ed 2mg AU004 IgG IgG Fraction 1mL PC004 IgG (H & L) IgG Fraction 1mL PC003 IgG (H & L) Monkey Adsorbed Affinity Purifi ed 1mL AU003.M IgG (Fd) IgG Fraction 1mL PC075 IgG1 Affinity Purifi ed 0.5mg AU006 IgG2 Affinity Purifi ed 0.5mg AU007 IgG3 Affinity Purifi ed 0.5mg AU008 IgG4 Affinity Purifi ed 0.5mg AU009 IgM IFE Grade Antisera Customer Specifi ed FX012 Kappa Light Chain Affinity Purifi ed 2mg AU015 Kappa Light Chain IFE Grade Antisera Customer Specifi ed FX015 Lambda Light Chain Affinity Purifi ed 2mg AU017 Lambda Light Chain IFE Grade Antisera Customer Specifi ed FX017 2
6 Monoclonal Antibodies Antibodies Human Complement - Sheep Polyclonal Antibodies Human IgG4 MAb Clone HP6025 IgG Fraction 0.2mg MC011 C1q IgG Fraction 1mL PC020 C4 Binding Protein IgG Fraction 1mL PC026 Factor H (ß1H) IgG Fraction 1mL PC030 Factor I (KAF/C3b Inactivator) IgG Fraction 1mL PC031 Human Coagulation Proteins - Sheep Polyclonal Antibodies Antithrombin III IgG Fraction 1mL PC040 von Willebrand Factor IgG Fraction 1mL PC054 Human Acute Phase Proteins - Sheep Polyclonal Antibodies Antithrombin III IgG Fraction 1mL PC040 Haptoglobulin IgG Fraction 1mL PC058 Other Human Proteins Sheep Polyclonal Antibodies Albumin IgG Fraction 1mL PC032 LD Isoenzyme V IgG Fraction 1mL PC154 Superoxide Dimutase (Cu/Zn) IgG Fraction 1mL PC077 Tamm Horsfall Protein (Uromucoid) IgG Fraction 1mL PC071 Transferrin IgG Fraction 1mL PC070 Monoclonal Antibodies CD23 Clone BU38 IgG Fraction 0.2mg MC112 3
7 FITC Conjugated Human Immunoglobulin Antibodies IgG1 Affinity Purified 0.5mg AF006 IgG2 Affinity Purified 0.5mg AF007 IgG3 Affinity Purified 0.5mg AF008 IgG4 Affinity Purified 0.5mg AF009 Kappa Light Chain Affinity Purified 1mg AF015 Lambda Light Chain Affinity Purified 1mg AF017 FITC Conjugated Human Complement/Coagulation Protein Antibodies Antibodies C1q IgG Fraction 1mL PF020 C3c IgG Fraction 1mL PF023 Von Willebrand Factor IgG Fraction 1mL PF054 HRP Conjugated Human Immunoglobulins - Sheep Polyclonal Antibodies IgG (H+L) Monkey Adsorbed Affinity Purified 1mg AP003.M IgG Affinity Purified 1mg AP004 IgG1 Affinity Purified 0.5mg AP006 IgG2 Affinity Purified 0.5mg AP007 IgG3 Affinity Purified 0.5mg AP008 IgG4 Affinity Purified 0.5mg AP009 IgA Affinity Purified 1mg AP010 IgM Affinity Purified 1mg AP012 Kappa Light Chain Affinity Purified 1mg AP015 Lambda Light Chain Affinity Purified 1mg AP017 HRP Conjugated Human Proteins - Sheep Polyclonal Antibodies Albumin IgG Fraction 1mL PP032 α1 a-trypsin IgG Fraction 1mL PP034 Transferrin IgG Fraction 1mL PP070 HRP Conjugated Human Immunoglobulins - Monoclonal Antibodies IgG4 clone HP6025 IgG Fraction 0.2mg MP011 4
8 Antibodies to Animal Proteins Antibodies Sheep Anti-Mouse α1 Hydroxylase IgG Fraction 1mL PC290 Donkey Anti-Sheep/Goat IgG Affinity Purifi ed 2mg AU360 (H+L) FITC Conjugated Antibodies to Animal Proteins Sheep Anti-Dog IgG (H+L) IgG Fraction 1mL PF230 HRP Conjugated Antibodies to Animal Proteins Sheep Anti-Mouse IgG (H+L) Affinity Purifi ed 1mg AP271 Sheep Anti-Mouse IgG Affinity Purifi ed 1mg AP272 Sheep Anti-Rabbit IgG (H+L) Affinity Purifi ed 1mg AP311 Donkey Anti-Sheep/Goat IgG (H+L) Affinity Purifi ed 1mg AP360 Antigens Purified Human Myeloma Antigens Binding Site myeloma antigens are isolated from human serum and extensively purified by ion exchange chromatography, gel filtration and affinity chromatography. The isotype and light chain type of the myeloma protein is determined by immunoelectrophoresis. These products are supplied in buffer at greater than 95% purity. Antigens Human IgG1 Kappa 1mL BP078 Human IgG2 Kappa 1ml BP080 Human IgG3 Kappa 1mL BP082 Human IgG4 Kappa 1mL BP084 5
9 Clinical Specimens USA / Germany only Clinical specimens from human patients are essential, but often overlooked components. Required for ensuring the validity and integrity of products prior to, and after market introduction, they are also necessary for a host of other critical studies: sample interference testing assay specific performance characteristics normal range determinations validation studies regulatory approval and clearance data and documentation Specimens are available for a multitude of analytes, in a variety of different matrices (e.g. serum, plasma, urine, CSF), all of which can be collected and supplied to include any additional diagnostic information needed. The integrity of specimens is always kept intact (frozen or refrigerated) and can be packaged to specific fill-volume requirements as a single source donor, or pooled sample. If necessary, required and requested documentation is completed according to jointly agreed SOPs and provided with each and every collection and shipment, along with our own CERTIFICATE OF TESTING for your records. Clinical Specimens To discuss your specific requirements contact us on: Analyte Groups Available Autoimmune Cardiac Diabetes Hormones Infectious Diseases Metabolic Special Proteins Therapeutic Drugs Clinical Chemistries Fertility Diabetes Haematology Immunology Thyroid Tumour Markers Please contact us if you do not see the group you require or check 6
10 Manufacturing Reagents Manufacturing Reagents Human Rheumatoid Factor (RF)/IgG Absorbent The accurate quantification of human IgM in infectious disease assays may be disrupted by the presence of IgM class Rheumatoid Factor (RF) and by Immunoglobulin G (IgG). Human RF/IgG Absorbent is a reagent designed to remove both IgM class Rheumatoid Factor and IgG from serum prior to the quantification of specific IgM. IgG REMOVAL CAPACITY RF / IgG Absorbent 15 mg/ml Whole Serum 1 x 10mL (Non-US) IC050 US Customers - please contact us on info@thebindingsite.com for country specific configuration and codes. 7
11 visit us for more information
12 Head Office: The Binding Site Group Ltd 8 Calthorpe Road Edgbaston Birmingham B15 1QT Tel: Fax: Germany, Austria, Switzerland: The Binding Site GmbH Robert-Bosch-Str. 2A Schwetzingen Germany Tel: +49 (0) Fax: +49 (0) office@bindingsite.de France: The Binding Site France 14 rue des Glairaux CS SAINT EGREVE CEDEX France Tel: +33 (0) Fax: +33 (0) Spain, Portugal: The Binding Site Spain Bruc 72 2ª planta, Barcelona Spain Tel: Fax: USA, Canada, Latin America: The Binding Site Inc Oberlin Drive, #101 San Diego CA United States of America Tel: Fax: Toll Free: info@thebindingsite.com Czech Republic, Slovak Republic: The Binding Site s.r.o. Sinkulova 55, Prague 4, Czech Republic Tel: Fax: Belgium, Netherlands, Luxembourg: The Binding Site SPRL/BVBA Dendermondestraat Antwerpen, Belgium Tel: +32 (0) Fax: +32 (0) Italy: The Binding Site Italy Via Zanica Grassobbio (BG) Italy Tel: Fax: , The Binding Site Group Ltd, Birmingham, UK. Not for use in U.S.A. June 2015 MKG776.1E
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