KKG Immunmonitoring Publikationsliste

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1 Bohne F, Chmielewski M, Ebert G, Wiegmann K, Kürschner T, Schulze A, Urban S, Krönke M, Abken H, Protzer U.: T cells redirected against Hepatitis-B-virus surface proteins eliminate infected hepatocytes. Gastroenterology 2008, 134: Bohne F, Protzer U.: Adoptive T-cell therapy as a therapeutic option in chronic viral hepatitis. J. Viral Hepatitis 2007, 14, Suppl 1: Brill, T.H., Kübler, H.R., Pohla, H., Buchner, A., Fend, F., Schuster, T., van Randenborgh, H., Paul, R., Kummer, T., Plank, C., Eisele, B., Breul, J., Hartung, R., Schendel, D.J., Gansbacher, B.: Therapeutic vaccination with an interleukin-2interferon-g-secreting allogeneic tumor vaccine in patients with progressive castration-resistant prostate cancer: a phase I/II trial Hum.Gene. Ther. 20, 1-11 (2009) Brill, T.H.*, Kübler, H.R.*, von Randenborgh, H.*, Fend, F.*, Pohla, H.*, Breul, J.*, Hartung, R.*, Paul, R.*, Schendel, D.J., Gansbacher, B.*: Allogeneic retrovirally transduced, IL-2- and IFN-gamma-secreting cancer cell vaccine in patients with hormone refractory prostate cancer--a phase I clinical trial. J. Gene Med. 9 (7), (2007) Butterfield, L.H., Disis, M.L., Fox, B.A., Lee, P.P., Khleif, S.N, Thurin, M., Trinchieri, G., Wang, E., Wigginton, J., Chaussabel, D., Coukos, G., Dhodapkar, M., Hakansson, L., Janetzki, S., Kleen, T.O., Kirkwood, J.M., Maccalli, C., Maecker, H., Maio, M., Malyguine, A., Masucci, G., Palucka, A.K., Potter, D.M., Ribas, A., Rivoltini, L., Schendel, D., Seliger, B., Selvan, S., S.L.ingluff, C.L., Stroncek, D.F., Streicher, H., Wu, X.F., Zeskind, B., Zhao, Y.D., Zocca, M.B., Zwierzina, H., Marincola, F.M.: A systematic approach to biomarker discovery; Preamble to "the isbtc-fda taskforce on immunotherapy biomarkers" J. Transl. Med. 6, 81 (2008) Cornberg M, Protzer U, Dollinger M, Petersen J, Wedemeyer H, Berg T, Jilg W, Erhardt A, Wirth S, Schirmacher P, Fleig WE, Manns M. Prophylaxis, diagnosis and therapy of Hepatitis-B-Virus-(HBV-)Infection: Upgrade of the german guideline. Z. Gastroenterologie 2007, 45: Cosma, A., Nagaraj, R., Staib, C., Diemer, C.*, Wopfner, F.*, Schätzl, H.*, Busch, D.H., Sutter, G., Goebel, F.D.*, Erfle, V.: Evaluation of modified Vaccinia Virus Ankara as an alternative vaccine against smallpox in chronically HIV Type 1-Infected individuals undergoing HAART. Aids Res. Hum.Retrov. 23, (2007) Ebelt, K., Babaryka, G., Frankenberger, B., Stief, C.G., Eisenmenger, W., Kirchner, T., Schendel, D.J., Noessner, E.: Prostate cancer lesions are surrounded by FOXP3(+), PD-1(+) and B7-H1(+)lymphocyte clusters Eur. J. Cancer 45 (9), (2009) Ebelt K, Babaryka G, Figel AM, Pohla H, Buchner A, Stief CG, Eisenmenger W, Kirchner T, Schendel DJ, Noessner E.: Dominance of CD4+ lymphocytic infiltrates with disturbed effector cell characteristics in the tumor microenvironment of prostate carcinoma. Prostate Jan 1;68(1):1-10

2 Endl, J.*, Rosinger, S.*, Schwarz, B.*, Friedrich, S.-O.*, Rothe, G.*, Karges, W.*, Schlosser, M.*, Eiermann, T.*, Schendel, D.J., Boehm, B.O.*: Co-expression of CD25 and Ox40 (CD134) receptors delineates autoreactive T-cells in type 1 diabetes. Diabetes 55, (2006) Frankenberger, B., Noessner, E., Schendel, D.J.: Immune suppression in renal cell carcinoma. Semin. Cancer Biol. 17 (4), (2007) Frankenberger, B., Regn, S., Geiger, C., Noessner, E., Falk, C.S., Pohla, H.*, Javorovic, M., Silberzahn, T., Wilde, S., Buchner, A.*, Siebels, M.*, Oberneder, R.*, Willimsky, G.*, Pezzutto, A.*, Blankenstein, T.*, Schendel, D.J.: Cell-based vaccines for renal cell carcinoma: genetically-engineered tumor cells and monocyte-derived dendritic cells. World J. Urol. 23; (2005) Frankenberger, B., Pohla, H. *, Noessner, E., Willimsky, G.*, Papier, B., Pezzutto, A.*, Kopp, J.*, Oberneder, R.*, Blankenstein, T.*, Schendel, D.J.: Influence of CD80, interleukin-2, and interleukin-7 expression in human renal cell carcinoma on the expansion, function, and survival of tumor-specific CTLs. ( equally contributed) Clin. Cancer Res. 11; (2005) Geiger, C., Nossner, E., Frankenberger, B., Falk, C.S., Pohla, H., Schendel, D.J.: Harnessing innate and adaptive immunity for adoptive cell therapy of renal cell carcinoma J. Mol. Med. 87 (6), (2009) Gudbjartsson, D.F., Bjornsdottir, U.S., Halapi, E., Helgadottir, A., Sulem, P., Jonsdottir, G.M., Thorleifsson, G., Helgadottir, H., Steinthorsdottir, V., Stefansson, H., Williams, C., Hui, J., Beilby, J., Warrington, N.M., James, A., Palmer, L.J., Koppelman, G.H., Heinzmann, A., Krueger, M., Boezen, H.M., Wheatley, A., Altmuller, J., Shin, H.D., Uh, S.T., Cheong, H.S., Jonsdottir, B., Gislason, D., Park, C.S., Rasmussen, L.M., Porsbjerg, C., Hansen, J.W., Backer, V., Werge, T., Janson, C., Jonsson, U.B., Ng, M.C.Y., Chan, J., So, W.Y., Ma, R., Shah, S.H., Granger, C.B., Quyyumi, A.A., Levey, A.I., Vaccarino, V., Reilly, M.P., Rader, D.J., Williams, M.J.A., van Rij, A.M., Jones, G.T., Trabetti, E., Malerba, G., Pignatti, P.F., Boner, A., Pescollderungg, L., Girelli, D., Olivieri, O., Martinelli, N., Ludviksson, B.R., Ludviksdottir, D., Eyjolfsson, G.I., Arnar, D., Thorgeirsson, G., Deichmann, K., Thompson, P.J., Wjst, M., Hall, I.P., Postma, D.S., Gislason, T., Gulcher, J., Kong, A., Jonsdottir, I., Thorsteinsdottir, U., Stefansson, K.: Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction Nat. Genet. 41 (3), (2009) Hartl, D.*, Griese, M.*, Nicolai, T.*, Zissel, G.*, Prell, C.*, Reinhardt, D.*, Schendel, D.J., Krauss- Etschmann, S.: A role for MCP-I/CCR2 in interstitial lung disease in children. Resp. Res., (2005) Hartl, D.*, Griese, M.*, Nicolai, T.*, Zissel, G.*, Prell, C.*, Konstantopoulos, N.*, Gruber, R.*, Reinhardt, D.*, Schendel, D.J., Krauss-Etschmann, S.*: Pulmonary chemokines and their receptors differentiate children with asthma and chronic cough. J. Allergy Clin. Immunol. 115, (2005)

3 Hartl, D.*, Griese, M.*, Kappler, M.*, Zissel, G.*, Reinhardt, D.*, Rebhan, C.*, Schendel, D.J., Krauss- Etschmann, S.: Pulmonary Th2 response in Pseudomonas aeruginosa-infected patients with cystic fibrosis. J. Allergy Clin. Immunol. 117, (2006) Hartl, D.*, Koller, B., Mehlhorn, A.T.*, Reinhardt, D.*, Nicolai, T.*, Schendel, D.J., Griese, M.*, Krauss-Etschmann, S.: Quantitative and functional impairment of pulmonary CD4+CD25hi regulatory T cells in pediatric asthma. J. Allergy Clin. Immunol. 119 (5), (2007) Hoffmann, D., Seebach, J., Cosma, A., Goebel, F.D., Strimmer, K., Schätzl, H.M., Erfle, V.: Therapeutic vaccination reduces HIV protein sequence variability. FASEB Journal: 22(2), (2008) Javorovic M, Wilde S, Zobywalski A, Noessner E, Lennerz V, Wölfel T, Schendel DJ.: Inhibitory effect of RNA pool complexity on stimulatory capacity of RNA-pulsed dendritic cells J. Immunother. (1997) Jan;31(1): Javorovic, M., Pohla, H.*, Frankenberger, B., Wölfel, T.*, Schendel, D.J.: RNA transfer by electroporation into mature dendritic cells leading to reactivation of effector-memory cytotoxic T lymphocytes: a quantitative analysis. Mol Ther. 12; (2005) Kastenmüller, W., Gasteiger, G., Stross, L., Busch, D.H., Drexler, I.: Mucosal Application of a Lyophilized Viral Vector Vaccine Confers Systemic and Protective Immunity toward Intracellular Pathogens J. Immunol. 182 (5), (2009) Kastenmüller, W., Gasteiger, G., Gronau, J.H., Baier, R., Ljapoci, R., Busch, D.H., Drexler, I.: Cross-competition of CD8+ T cells shapes the immunodominance hierarchy during boost vaccination. J. Exp. Med. 204 (9), (2007) Krauss-Etschmann, S., Niedermaier, S., Beyer, J., Campoy, C., Escolano, V., Decsi, T., Jakobik, V., Schendel, D.J., Demmelmair, H., Heinrich, J., Koletzko, B.V.: Current use of room disinfectants and allergic symptoms at the age of 4 years J. Allergy Clin. Immunol. 123 (5), (2009) Krauss-Etschmann, S. Hartl, D., Rzehak, P., Heinrich, J., Shadid, R., Del Carmen Ramírez-Tortosa, M., Campoy, C, Pardillo, S., Schendel, D.J., Decsi, T., Demmelmair, H., Koletzko, B.V., Nutraceuticals for Healthier Life Study Group: Decreased cord blood IL-4, IL-13, and CCR4 and increased TGF-beta levels after fish oil supplementation of pregnant women. J. Allergy Clin. Immun. 121 (2), (2008) Krauss-Etschmann S, Shadid R, Campoy C, Hoster E, Demmelmair H, Jiménez M, Gil A, Rivero M, Veszprémi B, Decsi T, Koletzko BV.: Effects of fish-oil and folate supplementation of pregnant women on maternal and fetal plasma concentrations of docosahexaenoic acid and eicosapentaenoic acid: a European randomized multicenter trial. Am. J. Clin. Nutr. 85 (5), (2007)

4 Krauss-Etschmann, S., Hartl, D., Heinrich, J., Thaqi, A., Prell, C., Campoy, C.*, Molina, F.S.*, Hector, A.*, Decsi,T.*, Schendel, D.J., Koletzko, B.V.*: Association between levels of Toll-like receptors 2 and 4 and CD14 mrna and allergy in pregnant women and their offspring. Clin. Immunol. 118, (2006) Krönig, H., Hofer, K., Conrad, H., Guilaume, P., Muller, J., Schiemann, M., Lennerz, V., Cosma, A., Peschel, C., Busch, DH., Romero, P., Bernhard, H.: Allorestricted T lymphocytes with a high avidity T-cell receptor towards NY- ESO-1 have potent anti-tumor activity Int. J. Cancer 125 (3), (2009) Kutscher, S., Dembek, C.J., Allgayer, S., Heltai, S., Stadlbauer, B., Biswas, P., Nozza, S., Tambussi, G., Bogner, J.R., Stellbrink, H.J., Goebel, F.D., Lusso, P., Tinelli, M., Poli, G., Erfle, V., Pohla, H., Malnati, M., Cosma, A.: The intracellular detection of MIP-1beta enhances the capacity to detect IFN- gamma mediated HIV-1-specific CD8 T-cell responses in a flow cytometric setting providing a sensitive alternative to the ELISPOT AIDS. Res. Ther. 5, 22 (2008) Levin, A., Hayouka, Z., Helfer, M., Brack-Werner, R., Friedler, A., Loyter, A.: Peptides derived from HIV-1 integrase that bind Rev stimulate viral genome integration PLoS ONE 4 (1), e4155 (2009) Mamani-Matsuda, M., Cosma, A., Weller, S., Faili, A., Staib, C., Garçon, L., Hermine, O., Adoue, D., Fieschi, C., Pers, J.O., Arakelyan, N., Varet, B., Sauvanet, A., Berger, A., Paye, F., Andrieu, J.M., Michel, M., Godeau, B., Buffet, P., Reynaud, C.A., Weill, J.C.: The human spleen is the main reservoir for life long memory B-cells. Blood: Mar 3; [Epub ahead of print] (2008) Markoullis, K., Bulian, D.; Hölzlwimmer, G.; Quintanilla-Martinez, L.; Heiliger, K.J.; Zitzelsberger, H.; Scherb, H.; Mysliwietz, J.; Uphoff, C.C.; Drexler, H.G.; Adler, T.; Busch, D.H.; Schmidt, J.; Mahabir, E.: Mycoplasma contamination of murine embryonic stem cells affects cell parameters, germline transmission and chimeric progeny Transgenic Res 18 (1), (2009) Raffegerst, S.H.; Hoelzlwimmer, G.; Kunder, S.; Mysliwietz, J.; Quintanilla-Martinez, L.; Schendel, D.J.: Diverse hematological malignancies including hodgkin-like lymphomas develop in chimeric MHC class II transgenic mice PLoS ONE 4 (12), e8539 (2009) Renström, J., Istvanffy, R., Gauthier, K., Shimono, A., Mages, J., Jardon-Alvarez, A., Kröger, M., Schiemann, M., Busch, D.H., Esposito, I., Lang, R., Peschel, C., Oostendorp, R.A.: Secreted frizzled-related protein 1 extrinsically regulates cycling activity and maintenance of hematopoietic stem cells Cell Stem Cell 5 (2), (2009) Rothenaigner, I., Kramer, S., Meggendorfer, M., Rethwilm, A.*, Brack-Werner, R.: Transduction of human neural progenitor cells with foamy virus vectors for differentiationdependent gene expression. Gene Ther. Doi: /gt (2008)

5 Rüttinger D, van den Engel NK, Winter H, Schlemmer M, Pohla H, Grützner S, Wagner B, Schendel DJ, Fox BA, Jauch KW, Hatz RA.: Adjuvant therapeutic vaccination in patients with non-small cell lung cancer made lymphopenic and reconstituted with autologous PBMC : first clinical experience and evidence of an immune response. J. Transl. Med. 5:43, 1-14 (2007) Rüttinger, D.*, Winter, H.*, van den Engel, N.K.*, Hatz, R.A.*, Schlemmer, M.*, Pohla, H.*, Grützner, S.*, Schendel, D.J., Fox, B.A.*, Jauch, K.-W.*: Immunotherapy of lung cancer: an update. Onkologie 29; (2006) Scheich, F.*, Duyster, J.*, Peschel, C.*, Bernhard, H.: The immunogenicity of Bcr-Abl expressing dendritic cells is dependent on the Bcr-Abl kinase activity and dominated by Bcr-Abl regulated antigens. Blood 110 (7), (2007) Schendel, D.J.: Dendritic cell vaccine strategies for renal cell carcinoma. Opin. Biol.Ther. 7 (2), (2007) Schleypen, J.S., Baur, N., Kammerer, R.*, Nelson, P.J.*, Rohrmann, K.*, Gröne, E.F.*, Hohenfellner, M.*, Haferkamp, A.*, Pohla, H.*, Schendel, D.J., Falk, C.S., Noessner, E.: Cytotoxic markers and frequencies predict functional capacity of natural killer cells infiltrating renal cell carcinoma. Clin. Cancer Res. 12; (2006) Schlosser, E.*, Mueller, M.*, Fischer, S.*, Basta, S.*, Busch, D.H., Gander, B.*, Groettrup, M.*: TLR ligands and antigen need to be coencapsulated into the same biodegradable microsphere for the generation of potent cytotoxic T lymphocyte responses. Vaccine 26 (13), (2008) Schuster IG, Busch DH, Eppinger E, Kremmer E, Milosevic S, Hennard C, Kuttler C, Ellwart JW, Frankenberger B, Nössner E, Salat C, Bogner C, Borkhardt A, Kolb HJ, Krackhardt AM.: Allorestricted T cells with specificity for the FMNL1-derived peptide PP2 have potent antitumor activity against hematologic and other malignancies. Blood 110, (2007) Shadid, R., Haarman, M.*, Knol, J.*, Theis, W.*, Beermann, C.*, Rjosk-Dendorfer, D.*, Schendel, D.J., Koletzko, B.V.*, Krauss-Etschmann, S.: Effects of galactooligosaccharide and long-chain fructooligosaccharide supplementation during pregnancy on maternal and neonatal microbiota and immunity-a randomized, doubleblind, placebo-controlled study. Am. J. Clin. Nutr. 86 (5), (2007) Stemberger, C., Neuenhahn, M., Gebhardt, F.E., Schiemann, M., Buchholz, V.R., Busch, D.H.: Stem cell-like plasticity of naive and distinct memory CD8(+) T cell subsets Semin. Immunol. 21 (2), (2009) Stemberger, C.*, Huster, K.M., Koffler, M.*, Anderl, F.*, Schiemann, M.*, Wagner, H., Busch, D.H.: A single naive CD8+ T cell precursor can develop into diverse effector and memory subsets.: Immunity 27 (6), (2007) Stemberger, C.*, Neuenhahn, M.*, Buchholz, V.R.*, Busch, D.H.: Origin of CD8+ Effector and Memory T Cell Subsets. Cell. Mol. Immunol. 4 (6), (2007)

6 Wilde, S.; Sommermeyer, D.; Frankenberger, B.; Schiemann, M.; Milosevic, S.; Spranger, S.; Pohla, H.; Uckert, W.; Busch, D.H.; Schendel, D.J.: Dendritic cells pulsed with RNA encoding allogeneic MHC and antigen induce T cells with superior antitumor activity and higher TCR functional avidity Blood 114 (10), (2009) Zobywalski, A., Javorovic, M., Frankenberger, B., Pohla, H.*, Kremmer, E., Bigalke, I., Schendel, D.J.: Generation of clinical grade dendritic cells with capacity to produce biologically active IL- 12p70. Biomed Central / J. Transl. Medicine 5:18, 1-16 (2007)

The immune system. Bone marrow. Thymus. Spleen. Bone marrow. NK cell. B-cell. T-cell. Basophil Neutrophil. Eosinophil. Myeloid progenitor

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