CV RESUME. Bernard Corvilain, MD PhD.

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1 Bernard Corvilain CV Resume CV RESUME Bernard Corvilain, MD PhD. Sept Professional address: DOB 05 Aug Service d'endocrinologie, Hôpital Erasme ULB, 808 Route de Lennik, 1070 Bruxelles. Ph : Fax: bcorvila@ulb.ac.be Current positions Faculty Physician (Chef de Clinique Adjoint), Service d'endocrinologie, Hôpital Erasme ULB (Université Libre de Bruxelles). Member of the board of the Belgian Thyroid Club Training, graduations, and former activities Doctor of Medecine (MD) ULB 1984 Specialist of Internal Medicine, PhD Thesis ("Agrégation de l'enseignement Supérieur") ULB, Research fellowship Fondation Erasme, Research Assistant, Belgian FNRS, Research fellowship Fondation Erasme,

2 Bernard Corvilain CV Resume Publications: 1. CORVILAIN, B., VAN SANDE, J., DUMONT, J.E. Inhibition by iodide of iodide binding to proteins : the "Wolff-Chaikoff" effect is caused by inhibition of H202 generation. Biochemical and Biophysical Research communications, 154, , GOLSTEIN, J., CORVILAIN, B., LAMY, F., PAQUER, D., DUMONT, J.E. Effects of a selenium deficient diet on thyroid function of normal and perchlorate treated rats. Acta Endocrinologica 118, , J.E. DUMONT, CORVILAIN, B., COCLET, J., RASPE, E., REUSE, S. Recent Progress in Fundamental Thyroidology with Relevance to the Prevention of Medical Consequences of a Nuclear Accident. In : Iodine Prophylaxis Following Nuclear Accidents. Pergamon Press, 32-37, RASPE, E., REUSE, S., MAENHOUT, C., ROGER, P., CORVILAIN, B., LAURENT, E., MOCKEL, J., LAMY, F., VAN SANDE, J., DUMONT, J.E. Importance and variability of transducing systems in the control of thyroid cell function, proliferation and differentiation. In : Growth regulation of thyroid gland and thyroid tumors. Eds Goretzki, P.E., Röher, H.D., Frontiers in Hormones Research. 18, 1-13, DUMONT, J.E., LEFORT, A., LIBERT, F., PARMENTIER, M., RASPE, E., REUSE, S., MAENHOUT, C., ROGER, P., CORVILAIN, B., LAURENT, E., MOCKEL, J., LAMY, F., VASSART, G. Transducing systems in the control of human thyroid cell function, proliferation and differentiation. In : Control of the thyroid gland. Eds Ekholm, R., Kohn, D., Wollman, S.H. Adv. Exp. Med. Biology, 261, , VAN SANDE, J., CORVILAIN, B., LAURENT, E., LEJEUNE, C., ROCMANS, P., MOCKEL, J., DUMONT, J.E. The biochemistry of autonomous thyroid nodules : clues on the pathogenesis. Acta Medica Austriaca, (1), 15-17, MAENHAUT, C., LEFORT, A., LIBERT, F., PARMENTIER, M., RASPE,E., ROGER, P.,CORVILAIN, B, LAURENT, E., REUSE, S., MOCKEL, J., LAMY, F., VAN SANDE, J., DUMONT, J.E. Function, proliferation and differentiation of the dog and human thyrocyte. in : Physiological regulation and biological function of thyreotropin. Eds. Pfeiffer E.F., Reaven G.M. Horm. Metab.Res. 23, 51-61, 1990.

3 Bernard Corvilain CV Resume REUSE, S., MAENHAUT, C., LEFORT, A., LIBERT, F., PARMENTIER,M., RASPE, E., ROGER, P., CORVILAIN, B., LAURENT, E., MOCKEL, J., LAMY, F., VANSANDE, J., VASSART, G., DUMONT, J.E. The control of human thyroid cell function, proliferation and differentiation. in : Activation and desensitization of transducing pathways.eds. Konijn T.M., Houslay M.D., Van Haastert P.J.M. NATO ASI Series. H 44, , CORVILAIN, B., GERARD, C., RASPE, E., LEFORT, A., MOCKEL, J., VAN SANDE, J., DUMONT, J.E. Hormonal regulation of iodination. in : Thyroperoxidase and thyroid autoimmunity. Ed. Carayon P., Ruf. J. INSERM - 207, 33-41, LAURENT, E., VAN SANDE, J., LUDGATE, M., CORVILAIN, B., ROCMANS, P., MOCKEL, J. Unlike thyrotropin, thyroid stimulating antibodies do not activate phospholipase C in human thyroid slices. J. Clin. Invest., 87, , CORVILAIN, B., VAN SANDE, J., LAURENT, E., DUMONT, J.E. The H2O2 generating system modulates protein iodination and the activity of the pentose phosphate pathway in dog thyroid. Endocrinology, 128, , RASPE, E., LAURENT, E., CORVILAIN, B., VERJANS, B., ERNEUX, C., DUMONT, JE. Control of the Intracellular Ca²+-Concentration and the Inositol Phosphate Accumulation in Dog Thyrocyte Primary Culture : Evidence for Different Kinetics of Ca²+-Phosphatidylinositol Cascade Activation and for Involvement in the Regulation of H2O2 Production Journal of Cell. Physiology, 250, , CORVILAIN, B. Clinical problem-solving : how sure is sure enough? N. Engl. J. Med., 327 (5), 360, (Letter) 14. CORVILAIN, B., CONTEMPRE, B., VANDERPAS, J., DUMONT, JE. Crétinisme, métabolisme thyroïdien et sélénium. Rev. Franç. Endocrinol. Clin. 33 n 3, , DUMONT, JE., CORVILAIN, B. Régulation de l'hormonogénèse par la TSH (Chapitre de livre). in : La thyroïde. Expansion scientifique française. Eds. Leclere J. et al , 1992

4 Bernard Corvilain CV Resume CORVILAIN, B., MATTE, J., LITVINE, C. Serum cholesterol in young men and cardiovascular disease. N. Engl. J. Med., 329 (2), 138, (Letter) 17. CORVILAIN, B., CONTEMPRE, B., LONGOMBE, AO., GOYENS, P., GERVY-DECOSTER, C., LAMY, F. Selenium and the thyroid : how the relationship was established. Am. J. Clin. Nutr. 57 (2 suppl.) : 244S-248S, DUMONT, JE., CORVILAIN, B, CONTEMPRE, B. The biochemistry of endemic cretinism: roles of iodine and selenium deficiency and goitrogens Mol. Cell. Endocrinol. 100, , CORVILAIN, B., LAURENT, E., LECOMTE, M., VAN SANDE, J.,DUMONT, JE. Role of the cyclic AMP and the PIP2 cascades in mediating the effects of thyrotropin and iodide on hormone synthesis and secretion in human thyroid slices. J. Clin. Endocrinol. Metab., 79, , CORVILAIN, B., ABRAMOWICZ, M., FERY, F., SCHOUTENS, A., VERLINDEN, M., BALASSE, EO., HOROWITZ, M. Effects of short term fasting on gastric emptying in normal and obese subjects. Relationship to oral glucose tolerance test. Am. J. of Physiology: 269:G512-G517, CORVILAIN, B., CONTEMPRE, B., MOCKEL J., ERMANS AM., DUMONT, JE. Autonomie thyroïdienne et goitre endémique. Rev. Franç. Endocrinol. Clin. 38 n 3, , CORVILAIN, B., SCHINOHORITIS, P. Treatment of thyrotoxicosis resistant to carbimazole with corticosteroids Postgrad Med J: 73:686, 1997 (Letter) 23. CORVILAIN, B., VAN SANDE, J.,DUMONT, JE., BOURDOUX P, ERMANS AM. Autonomy in endemic goiter. Thyroid, 8(1):107-13, COTTON F, SORLIN P, CORVILAIN B, FOCKEDEY JM, CAPEL P. Interference with oral anticoagulant treatment by oestrogen--influence of oestrogen administration route. Thromb Haemost Mar;81(3):471-2, 1999 (Letter) 25. CORVILAIN B, COLLYN L, VAN SANDE J, DUMONT JE. Stimulation by iodide of H 2 O 2 generation in thyroid slices from several species. Am.J.Physiol Apr;278(4):E692-9, 2000

5 Bernard Corvilain CV Resume CORVILAIN B, DUMONT JE, VASSART GToxic Adenoma and Toxic Multinodular goiter (Book chapter) In: The Thyroid 8 th Edition LE Brawerman and RD Utiger Editors Lippincott-Raven Publishers , DELEU S, ALLORY Y, RADULESCU A, PIRSON I, CARRASCO N, CORVILAIN B, SALMON I, FRANC B, DUMONT JE, VAN SANDE J, MAENHAUT C Characterization of autonomous thyroid adenoma: metabolism, gene expression and pathology. Thyroid. Feb;10(2):131-40, CORVILAIN,B.; VAN SANDE,J.; DUMONT,J.E.; VASSART,G.Somatic and Somatic and germline mutations of the TSH receptor and thyroid diseases Clin Endocrinol (Oxford) 55 (2) , CORVILAIN B, VAN SANDE J, MOCKEL J, DUMONT JE Régulation de la synthèse et de la sécrétion des hormones thyroïdiennes l'hormonogénèse par la TSH. (Chapitre de livre) In : La thyroïde. Des concepts à la pratique clinique 2 ème Edition Eds. Leclere J. et al. Elsevier Publisher , VAN SANDE J, BOEYNAEMS JM, CORVILAIN B, DUMONT JE Régulation de la fonction thyroïdienne par l'iode. (Chapitre de livre) In : La thyroïde. Des concepts à la pratique clinique 2 ème Edition Eds. Leclere J. et al. Elsevier Publisher , MORENO-REYES R, CORVILAIN B. Amiodarone induced thyroiditis (Letter) Lancet 2002 Jun 29;359(9325):2276