Danitza Nébor, Ph.D.

Transcription

1 Danitza Nébor, Ph.D. Professional contact Jackson Laboratory 600 Main Street Bar Harbor, ME Education Post- doctoral associate The Jackson laboratory Oct present Genetic modifiers of β- like globin gene switching Ph.D. University of French West Indies/ University Paris VII National institute of health and medical research (Inserm) Dec Sept 2010 Study of genetic and cellular factors involved in the variability of clinical expression of sickle cell anemia Postgraduate degree University of Paris VII (FRANCE) Sept July 2006 Sciences, health and application Specialty: cardiovascular Masters degree Sept June 2005 Physiology, cellular and molecular biology Bachelors Sept June 2004 Cellular biology and physiology Two year college degree Sept June 2003

2 Research projects October present: Genetic modifiers of β- like globin gene switching The Jackson laboratory Sept Aug 2012: Cloning and expression of gluthation S transferase gene in Macrobrachim Rosenbergii DYNECAR/University of French West Indies Apr Aug 2011: Clinical research on tropical and neurological diseases Clinical research associate Pointe- à- Pitre Hospital (Guadeloupe) Dec Sept 2010: Study of genetic and cellular factors involved in the variability of clinical expression of sickle cell anemia National institute of health and medical research (France / Guadeloupe) Sept July 2006: Role of cyclooxygenase 1 and 2 in the regulation of the microcirculation tone University of Paris VII (France) Sept June 2005: Effects of Warfarin and vitamin K on Gas6 and protein S expression in rat retina and blood National Center of Scientific Research (CNRS)/ University of Poitiers (France) Related professional experiences and qualifications Sept Aug 2012: Temporary researcher and college teacher University of French West Indies Teaching activities: - Lecture: Mechanisms of cancer and tropical diseases (from genetic mutation to clinical manifestation) - Tutorial: Genetic, human anatomy physiology of health - Practical courses: biochemistry and immunology April August 2011: Clinical research associate Pointe- à- Pitre Hospital

3 Awards San Francisco, California th ASH annual meeting: ASH Abstract Achievement Award Bar Harbor Maine, October 2014 IMGC 2014: Under- Represented Minority scholarship award Guadeloupe, June 2011 Award of the best PhD in science of the University of the French West Indies Marseille (FRANCE), October 2010 Red Cell and Iron club congress: Award of the best oral Communication Guadeloupe, November 2009 Award of the best oral presentation for Popularization University and associative service Elected representative of PhD students at doctoral school council, Sept Sept 2010 Vice president of the association of the young researchers from Guadeloupe Sept Dec Seminars organization - Discovery of science to children - Popularization of Science - Scientific TV documentaries President of CREO association : association of young formation and professional insertion, July Oct 2012 Memberships Member of the American society of hematology Member of the CAREST network: Caribbean Association for Researchers in Sickle Cell Disease and Thalassemia

4 Congresses 1. Poster presentation at Hematologia 2009, Cuba, May 2009 Association between erythrocyte Duffy antigen expression, inflammation status and clinical expression in SS patients 2. Oral presentation at red blood cells and iron club, Marseille (France), October 2010 Fetal hemoglobin and hydrocarbamide modulate the quantitative and qualitative profile of microparticles in sickle cell anemia children 3. Oral presentation at Kidney diseases congress, Pointe- à- Pitre hospital, December 2010 Albuminuria in sickle cell adults 4. Oral presentation at IMGC conference, Bar Harbor Maine, October 2014 Mapping of QTL modifying Hbb- bh1 expression in Klf1 Nan F2 and diversity outbred mice 5. Oral presentation at the 56th ASH annual meeting and exposition, San Francisco California, December 2014 Mechanisms Regulating Increased Embryonic βh1 Globin Expression in Adult Nan anemic Mice Publications 1. Nebor D, Durpes MC, Mougenel D, Mukisi- Mukaza M, Elion J, Hardy- Dessources MD, Romana M Association between Duffy antigen receptor for chemokines expression and levels of inflammation markers in sickle cell anemia patients. Clinical Immunology 136: Durpès MC, Nebor D, du Mesnil PC, Mougenel D, Decastel M, Elion J, Hardy- Dessources MD Effect of Interleukin- 8 and RANTES on the Gardos channel activity in sickle human red blood cells: role of the Duffy Antigen Receptor for Chemokines. Blood Cells, Molecules, and Diseases 44: Nebor D, Broquere C, Brudey K, Mougenel D, Tarer V, Connes P, Elion J, Romana M.Alpha- thalassemia is associated with a decreased occurrence and a delayed age- at- onset of albuminuria in sickle cell anemia patients Blood Cells, Molecules, and Diseases 45:

5 4. Nebor D, Bowers A, Hardy- Dessources MD, Knight- Madden J, Romana M, Reid H, Barthélémy JC, Cumming V, Hue O, Elion J, Reid M, Connes P; CAREST Study Group. Frequency of pain crises in sickle cell anemia and its relationship with the sympatho- vagal balance, blood viscosity and inflammation Haematologica 96(11): Tripette J, Hardy- Dessources MD, Beltan E, Sanouiller A, Bangou J, Chalabi T, Chout R, Hedreville M, Broquere C, Nebor D, Dotzis G, Hue O, Connes P. Endurance running trial in tropical environment: a blood rheological study Clin Hemorheol Microcirc. 47(4): Knight- Madden JM, Connes P, Bowers A, Nebor D, Hardy- Dessources MD, Romana M, Reid H, Pichon AP, Barthélémy JC, Cumming VB, Elion J, Reid M Relationship between Acute Chest Syndrome and the sympatho- vagal balance in adults with hemoglobin SS disease; a case control study. Clin Hemorheol Microcirc. 53(3):231-8) 7. Nébor D, Romana M, Santiago R, Vachiery N, Picot J, Broquere C, Chaar V, Doumdo L, Odièvre MH, Benkerrou M, Elion J Fetal hemoglobin and hydroxycarbamide moduate both plasma concentration and cellular origin of circulating microparticles in sickle cell anemia children. Haematologica. 98(6): Nebor D, Bowers A, Connes P, Hardy- Dessources MD, Knight- Madder J, Cummimg V, Reid M, Romana M. Plasma concentration of platelet- derived microparticles is related to painful vaso- occlusive phenotype severity in sickle cell anemia. PLoS One. 24;9(1):e87243.