7th POSTGRADUATE SYMPOSIUM

Transcription

1 Institute of Pathology In cooperation with:»» Leibniz Institute for Age Research (Fritz Lipmann Institute) IZKF Graduate Program for Experimental Medicine»» Leibniz Institute for Natural Products and Infection Biology Jena (Hans-Knöll-Institute) 7th POSTGRADUATE SYMPOSIUM ON CANCER RESEARCH Saturday, April 25, 2015 Altes Schloss Dornburg (Kaisersaal) 1

2 ORGANIZATION Institute of Pathology, Jena University in collaboration with» Interdisciplinary Center for Clinical Research (IZKF) Graduate Program for Experimental Medicine, University Jena» UniversitätsTumorCentrum (UTC) Jena» Leibniz Institute for Age Research (Fritz Lipmann Institute)» Leibniz Institute for Natural Products and Infection Biology Jena (Hans-Knöll-Institute)» Jena School of Molecular Medicine» Jena Graduate Academy Prof. Dr. Iver Petersen, Prof. Dr. Alexander Berndt Phone: +49-(3641) SCIENTIFIC COMMITEE Backsch, Claudia Häfner, Norman Baniahmad, Aria Heller, Regine Beck, James Friderich Hilger, Ingrid Berndt, Alexander Hochhaus, Andreas Berndt, Angela Huber, Otmar Böhmer, Frank-Dietmar Liehr, Thomas Chen, Yuan Markert, Udo Clement, Joachim H. Melle, Christian Dürst, Matthias Petersen, Iver Englert, Christoph Popp, Jürgen Ewald, Christian Schulz, Stefan Franz, Marcus Stallmach, Andreas Friedrich, Karlheinz Wang, Zhao-Qi Guntinas-Lichius, Orlando Weigand, Wolfgang Hansel, Alfred 2

3 LOCATION Kaisersaal, Altes Schloss Dornburg TRAVELLING By train: Take the regional train from Jena-Paradies to Dornburg (Saale). See following link to check the schedule: By car (from Jena): Caution: the street lead to Altes Schloss Dornburg is now under construction. Please take the alternate detour route. Give (Jena to: , to: , to:dornburg/saale) to your navigation or Google Map (Schloßplatz, Camburg, Germany) Das Symposium ist als ärztliche Fortbildungsveranstaltung im Rahmen des Fortbildungszertifikats der Landesärztekammer Thüringen anerkannt (Kategorie A, Punkte 9). 3

4 THIS SYMPOSIUM IS SUPPORTED BY: Boehringer Ingelheim Pharma GmbH & Co. KG....(with 500 ) Carl Zeiss Jena GmbH...(with 750 ) Dako Deutschland GmbH...(with 500 ) Lilly Deutschland GmbH...(with 750 ) Merck Serono GmbH...(with 500 ) Novartis Pharma GmbH...(with 1250 ) QIAGEN GmbH... (with symposium materials) Roche Pharma AG...(with 1000 ) Zytomed systems GmbH....(with 500 ) ZytoVision GmbH....(with 500 ) 4

5 PROGRAM 8:00 Registration 9:00 Welcome address Prof. Dr. O. Guntinas-Lichius, Vice Dean of Study Affairs of the Medical Faculty of the Friedrich Schiller University of Jena 9:10 JIP Cancer Graduation Award Introduction Prof. Dr. Andreas Hochhaus, Director of the Department for Internal Medicine II, Jena University ; Vice-dean for Research of Medical Faculty of FSU; Director of the UniversitätsTumorCentrum Jena Lecture of the laureate 9:30 Keynote lecture Prof. W.W. Franke (Helmholtz Group for Cell Biology, German Cancer Research Center DKFZ): Molecular Diagnostics: Immunocytochemistry using cytoskeletal and junctional cell type markers 10:30 Coffee break 11:00 ORAL PRESENTATIONS SESSION 1: TUMOR CELL BIOLOGY Chairs: Frank Böhmer, Daniel Kritsch 1 Inhibitor of Growth 2 Inhibits Androgen Receptor Signaling in Prostate Cancer Cells Pungsrinont, Thanakorn; Institute of Human Genetics, Jena University 2 Androgen-dependent regulation of long non-coding RNAs in prostate cancer Maiwald, Caroline; Institute of Human Genetics, Jena University 3 Androgen receptor-dependent regulation of htert Kacal, Merve; Institute of Human Genetics, Jena University 5

6 4 AR-dependent regulation of genes involved in epithelial-mesenchymal transition in prostate cancer cells Colditz, Juliane; Institute of Human Genetics, Jena University 5 Protein tyrosine phosphatase expression analysis in chronic myeloid leukemia (CML)- patient samples and cell lines Drube, Julia; Institute of Molecular Biology, Jena University 6 Bidirectional HGF/c-Met signalling in the bladder cancer microenvironment Jennek, Susanne; Institute of Biochemistry II, Jena University 7 A ChIP-Seq and microarray based approach identifies Wt1 target gene Dong, Lihua; Molecular Genetics, Leibniz Institute for Age Research- Fritz Lipmann Institute (FLI) 8 MCPH1 acts as a modulator of βtrcp2 to regulate mitotic entry Liu, Xiaoqian; Leibniz Institute for Age Research - Fritz Lipmann Institute (FLI) 13:00 Lunch Snack 13:45 POSTER SESSION 1: TUMOR CELL BIOLOGY Chairs: Regine Heller, Joachim Clement 9 The DNA damage independent function of NBS1 in brain development Wang, Pei; Leibniz Institute for Age Research - Fritz Lipmann Institute (FLI) 10 DNA double-strand break induces colocalization between 53BP1 and S100A11 Bayer, Cathrin; Working group Biomolecular Photonics, Jena University 11 BIRC3 aberrations in chronic and B-cell acute lymphocytic leukemia patients Alhourani, Eyad; Institute of Human Genetics, Jena University 6

7 12 Relevance of ITIH5 for cervical carcinogenesis Dittmann, Jessica; Department of Gynecology, Jena University 13 MLL gene displaying an important molecular biomarker in acute leukaemia Othman, Moneeb A.K.; Institute of Human Genetics, Jena University 14 Detection of cervical carcinoma specific biomarkers by digital PCR Carow, Katrin; Department of Gynecology, Jena University 15 Abnormal expression of keratin 19 in lung carcinoma cell lines Wölfel, Cornelius; Institute of Pathology, Jena University 16 The role of SKAP in mitosis Vranesic, Anita Cindric; Institute of Biochemistry II, Jena University 17 Desmocollin 3 acts as a tumor suppressor through inhibiting PI3K/AKT/ MDM2 signaling in human colorectal cancer Ma, Yunxia; Institute of Pathology, Jena University POSTER SESSION 2: TUMOR DIAGNOSTIC AND THERAPY Chairs: Karlheinz Friedrich, Marcus Franz 18 Synthesis and biological behavior of O,S-chelating platinum(ii) and ruthenium(ii) complexes Hildebrandt, Jana; Institute of Inorganic and Analytical Chemistry, Jena University 19 FAS-Expression and survival as possible predictors in Human Glioblastoma? Vestergaard, Anita-Maria; AG Experimentelle Neuroonkologie, Klinik für Neurochirurgie, Jena University 7

8 20 EGCG induces cell death in human glioblastoma cell cultures Kögler, Christine; AG Experimentelle Neuroonkologie, Klinik für Neurochirurgie, Jena University 21 Novel cryptic rearrangements in adult B-cell precursor acute lymphoplastic leukemia involving MLL-gene Rittscher, Katharina; Institute of Human Genetics, Jena University 22 Tumour comorbidities in polycystic kidney disease Joorabchi, Samrand; Institute of Pathology, Jena University 23 Role of protein tyrosine phosphatases in the development of antiangiogenic therapy resistance in renal cell carcinoma Weiland, Anne; Institute for Molecular Cell Biology, Centre for Molecular Biomedicine (CMB), Jena University 24 Activated gamma/delta (γδ) T cell subsets after Salmonella stimulation Polasky, Christina; Institute of Molecular Pathogenesis, Friedrich- Loeffler-Institut (FLI) 25 Effect of the autophagy inhibitor chloroquine on gefitinib-resistant lung cancer cells and clinical relevance of autophagy-associated proteins Schnitzler, Kai-Leonie; Institute of Pathology, Jena University 26 Does epithelial to mesenchymal transition influence ALA accumulation in bladder cancer cells? Schleier, Richard; Institute of Pathology, Jena University 27 Heterogeneous response in cellular survival to MTX-MNP and hyperthermia exposure Pömpner, Nadine; Institute of Diagnostic and Interventional Radiology, Jena University 8

9 POSTER SESSION 3: TUMOR MICROENVIRONMENT AND EPIGENETIC REGULATION Chairs: Yuan Chen, Thomas Liehr 28 Serum-depletion affects protein trophoblast expression, resembling a tumoral adaptive switch Novoa-Herran, S; Placenta-Labor, Department of Obstetrics, Jena University 29 Methylation of specific genes in the course of cervical carcinogenesis: correlation to gene expression Eiselt, Juliane; Department of Gynecology, Jena University 30 Characterization of genes related to cisplatin-resistance in ovarian carcinoma cell lines Kritsch, Daniel; Department of Gynecology, Jena University 31 Influence of soy phytoestrogens on the uterine gene expression in mice Favaro, Rodolfo R; Placenta-Labor, Department of Obstetrics, Jena University 32 Coated superparamagnetic nickel nanorods affect cell vitality and intracellular signalling Schmidt, Ann-Kathrin; Abt. Hämatologie und Internistische Onkologie, Jena University 33 Raman spectroscopical investigations of senescence in human primary fibroblast cells Eberhardt, Katharina; Leibniz Institute of Photonic Technology (IPHT) Jena 34 Proteasomal decline in endothelial senescence Meçe, Odeta; Institute for Molecular Cell Biology, Centre for Molecular Biomedicine (CMB), Jena University 9

10 35 Angiogenesis is dependent on endothelial autophagy the role of AMPK Spengler, Katrin; Institut for Molecular Biology, Centre for Molecular Biomedicine (CMB), Jena University 36 Sodium-hydrogen exchanger NHE1 in endothelial cells regulates angiogenesis Kryeziu, Nderim; Institute for Molecular Cell Biology, Centre for Molecular Biomedicine (CMB); Jena University 37 Multicellular spheroids: A model for nanoparticle-cell interaction studies Demut, Johanna; Abt. Hämatologie und Internistische Onkologie, Jena University 15:00 ORAL PRESENTATIONS SESSION 2: TUMOR DIAGNOSTIC AND THERAPY Chairs: Ferdinand von Eggeling, Susanne Jennek 38 Functional analysis of CAMK2N1 and RUNX3 in Ovarian Carcinogenesis Heinze, Karolin; Department of Gynecology, Jena University 39 Measuring G protein signaling with a fluorescence-based membrane potential assay Günther, Thomas; Department of Pharmacology and Toxicology, Jena University 40 MALDI-Imaging: Mapping the cancer Hoffmann, Franziska; ENT Department, Jena University 41 Classification and prediction of liver cancer by Raman imaging Tolstik, Tatiana; Department of Internal Medicine IV, Division of Gastroenterology, Hepatology and Infectious Diseases, Jena University 10

11 17:00 Break 42 The expression of the protein lysine demethylases KDM1A, KDM2B, KDM5B and KDM6B is associated with poor clinical outcome in childhood acute lymphoblastic leukaemia Walter, Elisabeth; Department of Paediatric Haematology and Oncology, Children s ; Jena University 43 Inhibition of Breast Cancer Proliferation by Androgen Receptor Antagonists Luko, Katarina; Institute of Human Genetics, Jena University 44 Molecular analysis of CETCs in patients with hepatocellular carcinoma Berger, Tina; Abt. Hämatologie und Internistische Onkologie, Jena University 45 Detection of fetal fibronectin variants in patients serum: Implications for individualized targeted tumor therapy using armed antibodies Ospel, Johanna; Department of Internal Medicine I, Jena University 17:30 Dinner / Awards 11

12 Institute of Pathology, Jena University Prof. Dr. Iver Petersen, Prof. Dr. Alexander Berndt Phone: +49-(3641)