Focal therapy for prostate cancer: An unproven technique or a reasonable alternative to radical prostatectomy?
|
|
- Julian Morgan
- 7 years ago
- Views:
Transcription
1 Focal therapy for prostate cancer: An unproven technique or a reasonable alternative to radical prostatectomy? January 21, 2010 By Fran Lowry [1] and Fran Lowry [1] In order for a new treatment modality to be considered efficacious, it needs to be evaluated by acceptable criteria and demonstrate an improvement on the natural course of the disease. In order for a new treatment modality to be considered efficacious, it needs to be evaluated by acceptable criteria and demonstrate an improvement on the natural course of the disease. This has not been the case for focal therapy for prostate cancer. Indeed, focal therapies for prostate cancer (see Table on page 29) are associated with considerable morbidities and have not been proven to cure prostate cancer, or at least reduce the morbidity of this disease, according to Michael O. Koch, MD, chairman of the department of urology at Indiana University in Indianapolis. No so fast, countered Mark Emberton, MD, senior lecturer in oncologic urology at University College London. In Dr. Emberton s estimation, focal therapy offers a definite alternative to radical prostatectomy for men who want active surveillance. Dr. Koch and Dr. Emberton scrutinized the role of prostate focal therapy during a debate at the 2009 Genitourinary Cancers Symposium in Orlando. No potential to cure prostate cancer Studies of focal therapy suffer from lack of long-term data. The longest published follow up with thermal ablative approaches to prostate cancer treatment is four years, said Dr. Koch, who is also the John P. Donohue Professor of Urology at Indiana university. At four years, the expected prostate cancer mortality would be approximately 4%. This number is too small for any of the published series to have adequate power and follow up to prove or disprove efficacy. Page 1 of 5
2 While it may be premature to outright dismiss focal therapy, it is possible to say that the modalities are associated with morbidity, including rectal fistulas, urethral sloughing, impotence, and incontinence. Focal therapies are not sham surgery in the sense that they do not treat the prostate, he said. They are sham surgeries, however, in the sense that they do not consistently ablate the entire prostate. He added that the available trials with focal therapy have been poorly controlled, have used inappropriate endpoints, and did not offer conclusive evidence of efficacy. A two-year follow-up study by a group in Florida found that 94% of their patients (45 of 48) who were treated with focal cryoablation had stable PSA scores based on ASTRO criteria. All biopsy results were negative in the 24 patients with stable PSA scores who routinely had biopsies, and no local recurrences were noted in treated areas. In 36 of 40 patients who were potent preoperatively, potency was maintained to the satisfaction of the patient. All 48 patients in the study were continent (Urol Oncol 26: , 2008). Page 2 of 5
3 Since these modalities do have toxicity, they should be considered sham techniques until their potential to cure prostate cancer, or at least reduce the morbidity of the disease, can be demonstrated, he said. In order to believe that focal therapy is appropriate, it is necessary to believe that the cancer can be accurately staged within the prostate and that all of the significant tumors can be detected. In addition, one has to believe that focal therapy can consistently and effectively treat all the tumor foci. And finally, you have to believe that treatment of the detected tumor foci will improve the morbidity or the mortality resulting from this disease and it should be better than what you can do with just surveillance, he said. Existing methods of selecting candidates for focal therapy leave much to be desired. Transrectal ultrasound with biopsy, as it is currently done, is a very poor way of detecting tumor foci, and radiographic imaging is not adequately sensitive, although its sensitivity is improving. Nor can it tell us the grade of these small tumors, Dr. Koch said. Page 3 of 5
4 He also questioned the effectiveness of current ablation techniques. If you want to talk about focal therapy of the prostate, you ought to make sure you can ablate the entire prostate if you really think these treatments can effectively eradicate prostate cancer. Focal therapy has been suggested as an option for low-risk prostate cancer, but in Dr. Koch s opinion, patients with these low-risk cancers should be put on active surveillance instead. Dr. Koch concluded that at this juncture, focal therapy has not been shown to effectively localize prostate cancer. Are we ready to conduct a phase III trial with focal therapy? I would say no, he said. Of course, if payers decide to reimburse for focal therapy, it may very well become the leading Page 4 of 5
5 treatment of low-risk prostate cancer. A major advance in prostate cancer treatment Focal treatment of prostate cancer is definitely an idea whose time has come, Dr. Emberton told his audience. Prostate cancer is the only cancer for which the entire gland is removed or treated regardless of tumor location, he pointed out. But this approach has been abandoned in breast and kidney cancer. The same approach should be taken in prostate cancer as well, he said. The wide array of treatment options available has given focal therapy a considerable boost, Dr. Emberton said. Technologies now exist that make focal treatment feasible. Cryosurgery, HIFU, photodynamic therapy, radiofrequency ablation, and brachytherapy can create localized necrosis within the prostate of a predetermined size in a relatively controlled manner, he said. While there may not be long-term data to support the use of these modalities in whole-gland therapy, all of these technologies are capable of destroying prostate tissue with millimeter accuracy, he said (Eur Urol 53: , 2008). Dr. Emberton acknowledged that focal therapy will never be suitable for all patients, just like partial nephrectomy is not suitable for all patients. He argued that it will be useful in men who put preserving genitourinary function at the top of their list. You can see here that having an option in the middle ground may serve the interests and address the utilities of a lot of patients we look after and treat, he said. The question that should be asked is, In men with early prostate cancer, can focal or zonal therapy, vs standard therapy, active surveillance, or whole-gland radical therapy, confer improved tolerability, less toxicity, comparable or acceptable efficacy, and less cost? he said. Focal therapy represents a major advancement in prostate cancer treatment, Dr. Emberton said. The therapy is controversial now but so was lumpectomy for breast cancer and partial nephrectomy for kidney cancer at one time, he added. Dr. Emberton acknowledged that long-term data on focal therapy are still needed. Nonetheless, its benefits are clear. Focal therapy virtually guarantees a man a normal genitourinary function by one to three months, he said. It is associated with the absence of clinically significant, clinically important, biologically important disease in all patients treated and evaluated to date, and it is associated with no evidence of disease recurrence. Source URL: sonable-alternative-radical-prostatectomy Links: [1] Page 5 of 5
Targeted Focal (Subtotal) Therapy for Early Stage Prostate Cancer
Targeted Focal (Subtotal) Therapy for Early Stage Prostate Cancer Duke K. Bahn, MD Prostate Institute of America (www.pioa.org) Ventura, California 888-234-0004 Published in PAACT newsletter Introduction:
More informationPSA Screening for Prostate Cancer Information for Care Providers
All men should know they are having a PSA test and be informed of the implications prior to testing. This booklet was created to help primary care providers offer men information about the risks and benefits
More informationFocal therapy for prostate cancer: seriously or seriously? Disclosures
Focal therapy for prostate cancer: seriously or seriously? Mitchell Kamrava, MD Assistant Clinical Professor Department of Radiation Oncology University of California Los Angeles Disclosures Speaking honorarium
More informationSaturation Biopsy vs. 3D Spatial Biopsy vs. Free Hand Ultrasound biopsy for Targeted Prostate Cancer Therapies
Saturation Biopsy vs. 3D Spatial Biopsy vs. Free Hand Ultrasound biopsy for Targeted Prostate Cancer Therapies John F. Ward, MD Assistant Professor University of Texas M. D. Anderson Cancer Center Ablation
More informationScreening for Prostate Cancer
Screening for Prostate Cancer It is now clear that screening for Prostate Cancer discovers the disease at an earlier and more curable stage. It is not yet clear whether this translates into reduced mortality
More informationDetection and staging of recurrent prostate cancer is still one of the important clinical problems in prostate cancer. A rise in PSA or biochemical
Summary. 111 Detection and staging of recurrent prostate cancer is still one of the important clinical problems in prostate cancer. A rise in PSA or biochemical recurrence (BCR) is the first sign of recurrent
More informationSRO Tutorial: Prostate Cancer Treatment Options
SRO Tutorial: Prostate Cancer Treatment Options May 7th, 2010 Daniel M. Aebersold Klinik und Poliklinik für Radio-Onkologie Universität Bern, Inselspital Is cure necessary in those in whom it may be possible,
More information7. Prostate cancer in PSA relapse
7. Prostate cancer in PSA relapse A patient with prostate cancer in PSA relapse is one who, having received a primary treatment with intent to cure, has a raised PSA (prostate-specific antigen) level defined
More informationProstate Cancer. Treatments as unique as you are
Prostate Cancer Treatments as unique as you are UCLA Prostate Cancer Program Prostate cancer is the second most common cancer among men. The UCLA Prostate Cancer Program brings together the elements essential
More informationBeyond the PSA: Genomic Testing in Localized Prostate Cancer
Beyond the PSA: Genomic Testing in Localized Prostate Cancer Kelvin A. Moses, MD, PhD Vanderbilt University Medical Center Wednesday, December 2, 2015 5:00 p.m. ET/2:00 p.m. PT About ZERO ZERO s mission
More informationThomas A. Kollmorgen, M.D. Oregon Urology Institute
Thomas A. Kollmorgen, M.D. Oregon Urology Institute None 240,000 new diagnosis per year, and an estimated 28,100 deaths (2012) 2 nd leading cause of death from cancer in U.S.A. Approximately 1 in 6 men
More informationRobotic Radical Prostatectomy: What s s the Advantage? Matthew T. Gettman, M.D. Associate Professor Department of Urology
Robotic Radical Prostatectomy: What s s the Advantage? Matthew T. Gettman, M.D. Associate Professor Department of Urology Prostate Cancer Epidemiology: 2009 Estimated new cases: 230,000 Estimated deaths:
More informationPSA Testing 101. Stanley H. Weiss, MD. Professor, UMDNJ-New Jersey Medical School. Director & PI, Essex County Cancer Coalition. weiss@umdnj.
PSA Testing 101 Stanley H. Weiss, MD Professor, UMDNJ-New Jersey Medical School Director & PI, Essex County Cancer Coalition weiss@umdnj.edu September 23, 2010 Screening: 3 tests for PCa A good screening
More informationThe introduction of breast-sparing surgery (ie, Male Lumpectomy : Focal Therapy for Prostate Cancer Using Cryoablation
Male Lumpectomy : Focal Therapy for Prostate Cancer Using Cryoablation Gary Onik, David Vaughan, Richard Lotenfoe, Martin Dineen, and Jeff Brady The introduction of breast-sparing surgery (ie, lumpectomy
More informationReview of Focal Therapy for Localized Prostate Cancer
Review of Focal Therapy for Localized Prostate Cancer Frances M. Martin and John F. Ward* Department of Urology, The University of Texas M. D. Anderson Cancer Center, Houston, Texas 2 PCRI Insights www.pcri.org
More informationto Know About Your Partner s
What You Need to Know About Your Partner s Prostate Cancer. A Guide for Wives, Partners, and the Men They Love. Providing Support for Your Partner Prostate cancer can be a physical and emotional challenge
More informationMALE LUMPECTOMY: FOCAL THERAPY IS THE FUTURE OF PROSTATE CANCER TREATMENT
MALE LUMPECTOMY: FOCAL THERAPY IS THE FUTURE OF PROSTATE CANCER TREATMENT GARY ONIK, MD THE ONIK PROSTATE CANCER CENTER - AVENTURA, FL CONTACT: KAREN BARRIE, MS (847) 502-1414 OR EMAIL: BARRIEMEDMARKETING@GMAIL.COM
More informationQuestions to ask my doctor: About prostate cancer
Questions to ask my doctor: About prostate cancer Being diagnosed with prostate cancer can be scary and stressful. You probably have a lot of questions and concerns. Learning about the disease, how it
More informationLocal Salvage Therapies After Failed Radiation for Prostate Cancer. Biochemical Failure after Radiation
Local Salvage Therapies After Failed Radiation for Prostate Cancer James Eastham, MD Memorial Sloan-Kettering Cancer Center New York, New York Biochemical Failure after Radiation ASTRO criteria 3 consecutive
More informationIn Practice Whole Body MR for Visualizing Metastatic Prostate Cancer
In Practice Whole Body MR for Visualizing Metastatic Prostate Cancer Prostate cancer is the second most common cancer in men worldwide, accounting for 15% of all new cancer cases. 1 Great strides have
More informationFocal Therapy for Localised Prostate Cancer
Focal Therapy for Localised Prostate Cancer SOGUG 2012 Miss Louise Dickinson NIHR Academic Clinical Fellow/ SpR in Urology Division of Surgery and Interventional Science, UCL & Department of Urology, University
More informationPROSTATE CANCER. Get the facts, know your options. Samay Jain, MD, Assistant Professor,The University of Toledo Chief, Division of Urologic Oncology
PROSTATE CANCER Get the facts, know your options Samay Jain, MD, Assistant Professor,The University of Toledo Chief, Division of Urologic Oncology i What is the Prostate? Unfortunately, you have prostate
More informationHigh Intensity Focused Ultrasound for Prostate Cancer
High Intensity Focused Ultrasound for Prostate Cancer Patient Information Exploring a Minimally Invasive Prostate Cancer Therapy The Choice for HIFU Worldwide A Patient s Guide to Prostate Cancer and Sonablate
More informationProstate cancer is the most common cause of death from cancer in men over age 75. Prostate cancer is rarely found in men younger than 40.
A.D.A.M. Medical Encyclopedia. Prostate cancer Cancer - prostate; Biopsy - prostate; Prostate biopsy; Gleason score Last reviewed: October 2, 2013. Prostate cancer is cancer that starts in the prostate
More informationAdvances in Prostate Imaging and Ablative Treatment of Prostate Cancer
Provided by the NYU Post-Graduate Medical School Advances in Prostate Imaging and Ablative Treatment of Prostate Cancer Friday Saturday June 19 20, 2015 New York City Register online: med.nyu.edu/cme/mi
More informationProstate Cancer Treatment: What s Best for You?
Prostate Cancer Treatment: What s Best for You? Prostate Cancer: Radiation Therapy Approaches I. Choices There is really a variety of options in prostate cancer management overall and in radiation therapy.
More informationQuestions to Ask My Doctor About Prostate Cancer
Questions to Ask My Doctor Being told you have prostate cancer can be scary and stressful. You probably have a lot of questions and concerns. Learning about the disease, how it s treated, and how this
More informationUpdate on Prostate Cancer: Screening, Diagnosis, and Treatment Making Sense of the Noise and Directions Forward
Update on Prostate Cancer: Screening, Diagnosis, and Treatment Making Sense of the Noise and Directions Forward 33 rd Annual Internal Medicine Update December 5, 2015 Ryan C. Hedgepeth, MD, MS Chief of
More informationFAQ About Prostate Cancer Treatment and SpaceOAR System
FAQ About Prostate Cancer Treatment and SpaceOAR System P. 4 Prostate Cancer Background SpaceOAR Frequently Asked Questions (FAQ) 1. What is prostate cancer? The vast majority of prostate cancers develop
More informationProstate Cancer Screening. A Decision Guide
Prostate Cancer Screening A Decision Guide This booklet was developed by the U.S. Department of Health and Human Services, Centers for Disease Control and Prevention (CDC). Is screening right for you?
More informationNEW HYBRID IMAGING TECHNOLOGY MAY HAVE BIG POTENTIAL FOR IMPROVING DIAGNOSIS OF PROSTATE CANCER
Media Release April 7, 2009 For Immediate Release NEW HYBRID IMAGING TECHNOLOGY MAY HAVE BIG POTENTIAL FOR IMPROVING DIAGNOSIS OF PROSTATE CANCER London, Ontario Improved hybrid imaging techniques developed
More informationProstate Cancer Screening. A Decision Guide for African Americans
Prostate Cancer Screening A Decision Guide for African Americans This booklet was developed by the U.S. Department of Health and Human Services, Centers for Disease Control and Prevention (CDC). Published
More informationRadiation Therapy in Prostate Cancer Current Status and New Advances
Radiation Therapy in Prostate Cancer Current Status and New Advances Arno J. Mundt MD Professor and Chairman Dept Radiation Oncology Moores Cancer Center UCSD Radiation Therapy Wilhelm Roentgen (1845-1923)
More informationKidney Cancer OVERVIEW
Kidney Cancer OVERVIEW Kidney cancer is the third most common genitourinary cancer in adults. There are approximately 54,000 new cancer cases each year in the United States, and the incidence of kidney
More informationRadiation Therapy in Prostate Cancer Current Status and New Advances
Radiation Therapy in Prostate Cancer Current Status and New Advances Arno J. Mundt MD Professor and Chairman Dept Radiation Oncology Moores Cancer Center UCSD Presentation Welcome Overview of UCSD, Moores
More informationPSA Screening and the USPSTF Understanding the Controversy
PSA Screening and the USPSTF Understanding the Controversy Peter C. Albertsen Division of Urology University of Connecticut Farmington, CT, USA USPSTF Final Report 1 Four Key Questions 1. Does PSA based
More informationCorporate Medical Policy Saturation Biopsy for Diagnosis and Staging of Prostate Cancer
Corporate Medical Policy Saturation Biopsy for Diagnosis and Staging of Prostate Cancer File Name: Origination: Last CAP Review: Next CAP Review: Last Review: saturation_biopsy_for_diagnosis_and_staging_of_prostate_cancer
More informationTO SCREEN OR NOT TO SCREEN: THE PROSTATE CANCER
TO SCREEN OR NOT TO SCREEN: THE PROSTATE CANCER DILEMMA Thomas J Stormont MD January 2012 http://www.youtube.com/watch?v=8jd 7bAHVp0A&feature=related related INTRODUCTION A government health panel (the
More informationHistorical Basis for Concern
Androgens After : Are We Ready? Mohit Khera, MD, MBA Assistant Professor of Urology Division of Male Reproductive Medicine and Surgery Scott Department of Urology Baylor College of Medicine Historical
More informationTreating Prostate Cancer
Treating Prostate Cancer A Guide for Men With Localized Prostate Cancer Most men have time to learn about all the options for treating their prostate cancer. You have time to talk with your family and
More informationBard: Prostate Cancer Treatment. Bard: Pelvic Organ Prolapse. Prostate Cancer. An overview of. Treatment. Prolapse. Information and Answers
Bard: Prostate Cancer Treatment Bard: Pelvic Organ Prolapse Prostate Cancer An overview of Pelvic Treatment Organ Prolapse Information and Answers A Brief Overview Prostate Anatomy The prostate gland,
More informationGuidelines for Cancer Prevention, Early detection & Screening. Prostate Cancer
Guidelines for Cancer Prevention, Early detection & Screening Prostate Cancer Intervention Comments & Recommendations For primary prevention, it has been suggested that diets low in meat & other fatty
More informationA Woman s Guide to Prostate Cancer Treatment
A Woman s Guide to Prostate Cancer Treatment Supporting the man in your life Providing prostate cancer support and resources for women and families WOMEN AGAINST PROSTATE CANCER A Woman s Guide to Prostate
More information855-DRSAMADI or 212-241-8779
SMART SURGERY NEWS MARCH 2013 Dr. David Samadi 855-DRSAMADI or 212-241-8779 YOUR PROSTATE CANCER NEWS PREVENTION DIAGNOSIS TREATMENT LIFE AFTER PROSTATE CANCER PREVENTION Prostate Cancer Need-to-Knows
More informationProstate Cancer Screening in Taiwan: a must
Prostate Cancer Screening in Taiwan: a must 吳 俊 德 基 隆 長 庚 醫 院 台 灣 醫 學 會 105 th What is the PSA test? The blood level of PSA is often elevated in men with prostate cancer, and the PSA test was originally
More information2010 SITE REPORT St. Joseph Hospital PROSTATE CANCER
2010 SITE REPORT St. Joseph Hospital PROSTATE CANCER Humboldt County is located on the Redwood Coast of Northern California. U.S census data for 2010 reports county population at 134,623, an increase of
More informationReport with statistical data from 2007
2008 Cancer Program Annual Report with statistical data from 2007 Lake Cumberland Regional Hospital 305 Langdon Streett Somerset, KY 42503 Telephone: 606-679-7441 Fax: 606-678-9919 Cancer Committee Mullai,
More informationProstate Cancer Screening: Are We There Yet? March 2010 Andrew M.D. Wolf, MD University of Virginia School of Medicine
Prostate Cancer Screening: Are We There Yet? March 2010 Andrew M.D. Wolf, MD University of Virginia School of Medicine Case #1 A 55 yo white man with well-controlled hypertension presents for his annual
More informationIndividual Prediction
Individual Prediction Michael W. Kattan, Ph.D. Professor of Medicine, Epidemiology and Biostatistics, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University Chairman, Department
More informationAdvanced Prostate Cancer Treatments
Advanced Prostate Cancer Treatments Guest Expert: Kevin, DO Associate Professor of Medical Oncology, Yale Cancer Center www.wnpr.org www.yalecancercenter.org Welcome to Yale Cancer Center Answers with
More informationSaturation Biopsy for Diagnosis and Staging of Prostate Cancer. Original Policy Date
MP 7.01.101 Saturation Biopsy for Diagnosis and Staging of Prostate Cancer Medical Policy Section Surgery Issue 12/2013 Original Policy Date 12/2013 Last Review Status/Date /12/2013 Return to Medical Policy
More informationThese rare variants often act aggressively and may respond differently to therapy than the more common prostate adenocarcinoma.
Prostate Cancer OVERVIEW Prostate cancer is the second most common cancer diagnosed among American men, accounting for nearly 200,000 new cancer cases in the United States each year. Greater than 65% of
More informationPSA screening in asymptomatic men the debate continues www.bpac.org.nz keyword: psa
PSA screening in asymptomatic men the debate continues www.bpac.org.nz keyword: psa Key messages: PSA is present in the benign and malignant prostate There is currently no national screening programme
More informationProstate Cancer 2014
Prostate Cancer 2014 Eric A. Klein, M.D. Chairman Glickman Urological and Kidney Institute Professor of Surgery Cleveland Clinic Lerner College of Medicine Incidence rates, US Men Mortality Rates, US Men
More informationAFTER DIAGNOSIS: PROSTATE CANCER Understanding Your Treatment Options
AFTER DIAGNOSIS: PROSTATE CANCER Understanding Your Treatment Options INTRODUCTION This booklet describes how prostate cancer develops, how it affects the body and the current treatment methods. Although
More informationImplementation Date: April 2015 Clinical Operations
National Imaging Associates, Inc. Clinical guideline PROSTATE CANCER Original Date: March 2011 Page 1 of 5 Radiation Oncology Last Review Date: March 2015 Guideline Number: NIA_CG_124 Last Revised Date:
More informationAdvice to patients about the PSA (prostate-specific antigen) blood test: frequently-asked questions
Advice to patients about the PSA (prostate-specific antigen) blood test: frequently-asked questions What is the PSA blood test? If you want more information before deciding to have this test, it is important
More informationSurvivorship Care Plans Guides for Living After Cancer Treatment
Survivorship Care Plans Guides for Living After Cancer Treatment Institute of Medicine Report 2005 Recommendations for meeting needs of cancer survivors Implement survivorship care plan Build bridges
More information1. What is the prostate-specific antigen (PSA) test?
1. What is the prostate-specific antigen (PSA) test? Prostate-specific antigen (PSA) is a protein produced by the cells of the prostate gland. The PSA test measures the level of PSA in the blood. The doctor
More informationThe 4Kscore blood test for risk of aggressive prostate cancer
The 4Kscore blood test for risk of aggressive prostate cancer Prostate cancer tests When to use the 4Kscore Test? Screening Prior to 1 st biopsy Prior to negative previous biopsy Prognosis in Gleason 6
More informationProstate Cancer Action Plan: Choosing the treatment that s right for you
Prostate Cancer Action Plan: Choosing the treatment that s right for you Segment 1: Introduction Trust me, there's a better way to choose a treatment for your prostate cancer. Watching this program is
More informationAdvances in Diagnostic and Molecular Testing in Prostate Cancer
Advances in Diagnostic and Molecular Testing in Prostate Cancer Ashley E. Ross MD PhD Assistant Professor Urology, Oncology, Pathology Johns Hopkins School of Medicine September 24, 2015 1 Disclosures
More informationGleason Score. Oncotype DX GPS. identified for. about surveillance. time to get sophisticated
patient: MARK SMITH PSA 6.2 Gleason Score 6 Oncotype DX GPS 8 identified for active surveillance time to get sophisticated about surveillance Accurate prediction of prostate cancer risk is needed at the
More informationIssues Concerning Development of Products for Treatment of Non-Metastatic Castration- Resistant Prostate Cancer (NM-CRPC)
Issues Concerning Development of Products for Treatment of Non-Metastatic Castration- Resistant Prostate Cancer (NM-CRPC) FDA Presentation ODAC Meeting September 14, 2011 1 Review Team Paul G. Kluetz,
More informationMagnetic Resonance Imaging Targeted Biopsy of the Prostate
Applies to all products administered or underwritten by Blue Cross and Blue Shield of Louisiana and its subsidiary, HMO Louisiana, Inc.(collectively referred to as the Company ), unless otherwise provided
More informationAn Introduction to PROSTATE CANCER
An Introduction to PROSTATE CANCER Being diagnosed with prostate cancer can be a life-altering experience. It requires making some very difficult decisions about treatments that can affect not only the
More informationPrecise, Minimally Invasive Prostate Cancer Removal
Precise, Minimally Invasive Prostate Cancer Removal Learn why da Vinci Surgery may be your best treatment option 1 Beyond Minimally Invasive For Prostate Cancer 1 Facing Prostate Cancer Prostate cancer
More informationHow To Know If You Should Get A Brachytherapy Or Radioactive Seed Implantation
MEDICAL POLICY SUBJECT: BRACHYTHERAPY OR PAGE: 1 OF: 5 If the member's subscriber contract excludes coverage for a specific service it is not covered under that contract. In such cases, medical policy
More informationRobert Bristow MD PhD FRCPC
Robert Bristow MD PhD FRCPC Clinician-Scientist and Professor, Radiation Oncology and Medical Biophysics, University of Toronto and Ontario Cancer Institute/ (UHN) Head, PMH-CFCRI Prostate Cancer Research
More informationSONABLATE 450 FOR THE TREATMENT OF LOCALLY RECURRENT PROSTATE CANCER PMA P130002 SPONSOR EXECUTIVE SUMMARY
SONABLATE 450 FOR THE TREATMENT OF LOCALLY RECURRENT PROSTATE CANCER PMA P130002 SPONSOR EXECUTIVE SUMMARY FDA Advisory Committee Meeting Gastroenterology and Urology Devices Panel Meeting Date: October
More informationFocal Therapy for Prostate Cancer
Focal Therapy for Prostate Cancer Blayne Welk UBC Urology Grand Rounds, Oct 1, 2008 Outline Introduction Rationale for focal therapy Targeted modalities - HIFU - Cyrotherapy - Up & coming - Photodynamic
More informationEarly Prostate Cancer: Questions and Answers. Key Points
CANCER FACTS N a t i o n a l C a n c e r I n s t i t u t e N a t i o n a l I n s t i t u t e s o f H e a l t h D e p a r t m e n t o f H e a l t h a n d H u m a n S e r v i c e s Early Prostate Cancer:
More informationHEALTH NEWS PROSTATE CANCER THE PROSTATE
HEALTH NEWS PROSTATE CANCER THE PROSTATE Prostate comes from the Greek meaning to stand in front of ; this is very different than prostrate which means to lie down flat. The prostate is a walnut-sized
More information4/8/13. Pre-test Audience Response. Prostate Cancer 2012. Screening and Treatment of Prostate Cancer: The 2013 Perspective
Pre-test Audience Response Screening and Treatment of Prostate Cancer: The 2013 Perspective 1. I do not offer routine PSA screening, and the USPSTF D recommendation will not change my practice. 2. In light
More informationFocus on PSA Screening for Prostate Cancer Vol. 28 Supplement, February 2012. Prostate Cancer: Should We Be Screening?
Focus on PSA Screening for Prostate Cancer Vol. 28 Supplement, February 2012 Prostate Cancer: Should We Be Screening? INSIDE THIS ISSUE 2 Why the Controversy? 3 Active Surveillance 4 The Radical Prostatectomy
More informationDiagnosis of Recurrent Prostate Tumor at Multiparametric Prostate MRI: Pearls and Pitfalls
Diagnosis of Recurrent Prostate Tumor at Multiparametric Prostate MRI: Pearls and Pitfalls Mark Notley, MD; Jinxing Yu, MD; Ann S. Fulcher, MD; Mary A. Turner, MD; Don Nguyen, MD Virginia Commonwealth
More informationPROSTATE CANCER 101 WHAT IS PROSTATE CANCER?
PROSTATE CANCER 101 WHAT IS PROSTATE CANCER? Prostate cancer is cancer that begins in the prostate. The prostate is a walnut-shaped gland in the male reproductive system located below the bladder and in
More informationTreatment Options After Failure of Radiation Therapy A Review Daniel B. Rukstalis, MD
MANAGEMENT OF RADIATION FAILURE IN PROSTATE CANCER Treatment Options After Failure of Radiation Therapy A Review Daniel B. Rukstalis, MD Division of Urology, MCP Hahnemann University, Philadelphia, PA
More informationTreatment of localized prostate cancer using high-intensity focused ultrasound
Original Article HIFU FOR LOCALIZED PROSTATE CANCER UCHIDA et al. Treatment of localized prostate cancer using high-intensity focused ultrasound TOYOAKI UCHIDA, HIROSHI OHKUSA, YASUNORI NAGATA, TORU HYODO*,
More informationProstate Cancer In-Depth
Prostate Cancer In-Depth Introduction Prostate cancer is the most common visceral malignancy among American men. In the year 2003, there are expected to be 220,000 new cases and nearly 29,000 deaths in
More informationProstate cancer. Christopher Eden. The Royal Surrey County Hospital, Guildford & The Hampshire Clinic, Old Basing.
Prostate cancer Christopher Eden The Royal Surrey County Hospital, Guildford & The Hampshire Clinic, Old Basing. Screening Screening men for PCa (prostate cancer) using PSA (Prostate Specific Antigen blood
More informationBJUI. Overall, 71% had no evidence of disease following salvage HIFU. RESULTS. Study Type Therapy (case series) Level of Evidence 4
2008 The Authors. Journal compilation 2008 BJU International Original Article HIFU AS SALVAGE THERAPY FOR RECURRENT PROSTATE CANCER AFTER EBRT ZACHARAKIS et al. BJUI BJU INTERNATIONAL The feasibility and
More informationProstate Cancer Guide. A resource to help answer your questions about prostate cancer
Prostate Cancer Guide A resource to help answer your questions about prostate cancer Thank you for downloading this guide to prostate cancer treatment. We know that all the information provided online
More informationTransrectal high-intensity focused ultrasound for the treatment of localized prostate cancer: Eight-year experience
International Journal of Urology (2009) 16, 881 886 doi: 10.1111/j.1442-2042.2009.02389.x Original Article: Clinical Investigationiju_2389 881..886 Transrectal high-intensity focused ultrasound for the
More informationThe Business of Prostate Cancer Care: A Clinician-Researcher s Perspective
The Business of Prostate Cancer Care: A Clinician-Researcher s Perspective David F. Penson, MD, MPH Departments of Urology and Preventive Medicine Keck School of Medicine University of Southern California
More informationDIAGNOSIS OF PROSTATE CANCER
DIAGNOSIS OF PROSTATE CANCER Determining the presence of prostate cancer generally involves a series of tests and exams. Before starting the testing process, the physician will ask questions about the
More informationMODULE 8: PROSTATE CANCER: SCREENING & MANAGEMENT
MODULE 8: PROSTATE CANCER: SCREENING & MANAGEMENT KEYWORDS: Prostate cancer, PSA, Screening, Radical Prostatectomy LEARNING OBJECTIVES At the end of this clerkship, the medical student will be able to:
More informationThe PLCO Trial Not a comparison of Screening vs no Screening
PSA Screening: Science, Politics and Uncertainty David F. Penson, MD, MPH Hamilton and Howd Chair of Urologic Oncology Professor and Chair, Department of Urologic Surgery Director, Center for Surgical
More informationPROSTATE CANCER. Normal-risk men: No family history of prostate cancer No history of prior screening Not African-American
PROSTATE CANCER 1. Guidelines for Screening Risk Factors Normal-risk men: No family history of prostate cancer No history of prior screening Not African-American High-risk men: Family history of prostate
More informationRole of MRI in the Diagnosis of Prostate Cancer, A Proposal
Clinical and Experimental Medical Sciences, Vol. 1, 2013, no. 3, 111 116 HIKARI Ltd, www.m-hikari.com Role of MRI in the Diagnosis of Prostate Cancer, A Proposal W. Akhter Research Fellow Urology, Bartshealth
More informationMetastatic Renal Cell Carcinoma: Staging and Prognosis of Three Separate Cases.
Metastatic Renal Cell Carcinoma: Staging and Prognosis of Three Separate Cases. Abstract This paper describes the staging, imaging, treatment, and prognosis of renal cell carcinoma. Three case studies
More informationTechnical Advices for Prostate Needle Biopsy Under Transrectal Ultrasound Guidance
Technical Advices for Prostate Needle Biopsy Under Transrectal Ultrasound Guidance Makoto Ohori 1 and Ayako Miyakawa 2 1 Dept. of Urology, Tokyo Medical University 2 Dept. of Molecular Medicine and Surgery,
More informationLocally Recurrent Prostate Cancer After Initial Radiation Therapy: A Comparison of Salvage Radical Prostatectomy Versus Cryotherapy
Locally Recurrent Prostate Cancer After Initial Radiation Therapy: A Comparison of Salvage Radical Prostatectomy Versus Cryotherapy Louis L. Pisters,*, Dan Leibovici, Michael Blute, Horst Zincke, Thomas
More informationTransrectal High Intensity Focused Ultrasound for the Treatment of Localized Prostate Cancer
International Symposium on Therapeutic Ultrasound, Seattle, 2002. Transrectal High Intensity Focused Ultrasound for the Treatment of Localized Prostate Cancer T. Uchida 1, N. T. Sanghvi 2 T. Satoh 1, A.
More informationBRACHYTHERAPY OR RADIOACTIVE SEED IMPLANTATION CANCER OF THE PROSTATE
BRACHYTHERAPY OR RADIOACTIVE SEED IMPLANTATION CANCER OF THE PROSTATE Prostate cancer, like other cancers, is a disease of the body's cells. Normal cells reproduce themselves by dividing--facilitating
More informationProstate Cancer? Why Radical Surgery/Robotic Prostatectomy Is NOT For You. Bert Vorstman MD, MS, FAAP, FRACS, FACS
Prostate Cancer? Why Radical Surgery/Robotic Prostatectomy Is NOT For You. Bert Vorstman MD, MS, FAAP, FRACS, FACS Urological surgeons are well aware that most men die with their prostate cancer without
More informationThe PSA Controversy: Defining It, Discussing It, and Coping With It
The PSA Controversy: Defining It, Discussing It, and Coping With It 11 TH ANNUAL SYMPOSIUM ON MEN S HEALTH June 12, 2013 The PSA Controversy Defining It, Discussing It and Coping With It As of May 2012,
More informationAnalysis of Prostate Cancer at Easter Connecticut Health Network Using Cancer Registry Data
The 2014 Cancer Program Annual Public Reporting of Outcomes/Annual Site Analysis Statistical Data from 2013 More than 70 percent of all newly diagnosed cancer patients are treated in the more than 1,500
More informationSummary 1. KEY FINDINGS The Office of Technology Assessment (OTA) concludes that research has not yet been completed to determine CHAPTER
CHAPTER 1 Summary 1 rostate cancer is a common and serious malignancy among Medicare-age men. 1 In 1995, 244,000 new cases and 40,400 deaths are anticipated from this disease; men age 65 and older bear
More informationPATIENT GUIDE. Localized Prostate Cancer
PATIENT GUIDE Localized Prostate Cancer The prostate* is part of the male reproductive system. It is about the same size as a walnut and weighs about an ounce. As pictured in Figure 1, the prostate is
More information