Science-based metabolic detoxification formulas from the industry leader.

Transcription

1 Clinical Guide for Metabolic Detoxification Science-based metabolic detoxification formulas from the industry leader. Reliable protocols for reliable outcomes. The health of your patients depends on it.*

2 There s a lot of confusion out there regarding detoxification. It s my job to offer my patients a science-based, effective option. * Metabolic Detoxification: Supporting the 3 Phases * Metabolic detoxification consists of 3 major detoxification pathways: Phase I (functionalization), Phase II (conjugation), and Phase III (antiporter activity). In this process, fat-soluble toxins must undergo transformation and become water-soluble before they can be excreted. Water-soluble toxins entering the body do not require transformation and are easily eliminated through the stool, sweat, or urine. Toxic Exposure Advanced Metabolic Detoxification Formulas Featuring TM medical food for fibromyalgia patients formulated to nutritionally support the 3 phases of metabolic detoxification. Toxic Exposure Toxins enter the body. Some are eliminated via the stool, sweat, or urine, while others are transported to the liver. Translocation Intestine Elimination Aids the Intestine Features a low allergy potential and balanced solubility (osmolality), reducing translocation of toxins to the liver. Phase I Functionalization Enzymes released by the liver breakdown xenobiotics, producing harmful free radicals. Phase II Conjugation Large molecules join together with modified xenobiotics to produce harmless, watersoluble substances, which are released to the kidney or back to the GI tract. Translocation Phase I Phase II Liver Benefits Phase I & II Enhances activities of several liver detoxification enzymes and provides antioxidants to support the clearance of reactive intermediary compounds. Phase III Antiporter Activity The water soluble substance is excreted via the urine or stool. Phase III Kidney Elimination Benefits Phase III Supports the excretion of toxins with a high alkaline reserve.

3 Clinically Tested Medical Food Program Clinically Tested Medical Food Program Medical Food is a clinically tested medical food formulated to provide specialized nutritional support to address altered pain signaling and neuromuscular function in patients with fibromyalgia. UltraClear RENEW is designed for individuals who may benefit from additional support for liver function, and features an array of nutrients in a low-allergen-potential macronutrient base to support Phase II liver detoxification. In preliminary research with fibromyalgia patients with dental amalgams, administration of was associated with significant decreases in FibroQuest scores, including pain and stiffness. Designed to support healthy Phase I, Phase II, and Phase III liver detoxification function. Helps to address altered pain signaling. Supports healthy neuromuscular function. Flavor: Original Flavor Serving size: About 2 Scoops (38 g) Calories 150 Total Fat Saturated Fat Trans Fat Cholesterol Sodium Potassium Carbohydrate Dietary Fiber Sugars Protein Vitamin A (as beta-carotene) Vitamin A (as retinyl palmitate) Vitamin C Calcium Iron Vitamin D Vitamin E Thiamin Riboflavin Niacin Vitamin B 6 FiBROMYALGIA 3 g 1 g 0 g 0 mg 220 mg 520 mg 20 g 3 g 9 g 12 g 4000 IU 1000 IU 300 mg 1 35 IU 42 IU 2 mg 2 mg 7 mg 3.4 mg Folic Acid Vitamin B 12 Biotin Pantothenic Acid Phosphorus Iodine Magnesium Zinc Copper Manganese Chromium Chloride Proprietary Spent Hops (Humulus lupulus) Powder L-Glycine Prune (Prunus domestica) Skin Extract L-Glutamine Watercress (Nasturtium officinale) Whole Plant Extract Ellagic Acid [from pomegranate (Punica granatum) Whole Fruit Extract] DL-Methionine L-Threonine L-Lysine Sulfate (magnesium sulfate) L-Cysteine Catechins (from decaffeinated green tea extract) 80 mcg 3.6 mcg 135 mcg 36 mg 230 mg 53 mcg 160 mg 10 mg 50 mcg 460 mg 1000 mg 800 mg 125 mg 100 mg 67 mg 35 mg 35 mg 20 mg 15 mg 15 mg Ingredients: Rice protein concentrate, rice syrup solids, fructose, natural flavors, magnesium citrate, proprietary spent hops powder (Humulus lupulus), partially hydrolyzed guar gum, dipotassium phosphate, olive oil, medium chain triglycerides, L-glycine, sodium chloride, calcium citrate, potassium citrate, magnesium chloride, silica, ascorbic acid, pomegranate extract, prune skin extract, L-glutamine, zinc gluconate, d-alpha tocopheryl acetate, watercress extract, DL-methionine, L-lysine HCl, L-threonine, decaffeinated green tea extract, D-calcium pantothenate, L-cysteine HCl, magnesium sulfate, vitamin A (beta-carotene, retinyl palmitate), niacinamide, copper gluconate, pyridoxine HCl, thiamin HCl, riboflavin, chromium polynicotinate, biotin, folic acid, potassium iodide, cyanocobalamin, and cholecalciferol. Directions: Blend, shake, or briskly stir about 2 level scoops of into 8 ounces of chilled water or juice twice daily or as directed by your healthcare practitioner. For highly sensitive individuals, consider reducing consumption to 1/2 to 1 scoop with 4 to 5 ounces of chilled water or juice twice daily during the first 3 to 4 days before starting a full daily dose. Form: 28.5 oz (1 lb 12.5 oz) (798 g) Powder Warning: Excess vitamin A intake may be toxic and may increase the risk of birth defects. Pregnant women and women who may become pregnant should not exceed 5000 IU of preformed vitamin A (retinyl palmitate) per day. Caution: Do not use if pregnant or nursing. Not recommended for individuals taking anticoagulant medications. Formulated to Exclude: Wheat, gluten, soy protein, dairy products, egg, nuts, tree nuts, fish, crustacean shellfish, colors, artificial sweeteners, artificial flavors, and preservatives. Notice: This product is to be used under the direct supervision of a physician or other licensed healthcare practitioner. Do not engage in any diet supplying less than 800 calories per day without medical supervision. Saturated fat content is contributed by a beneficial form of fat, medium-chain triglycerides, which have recognized health benefits. Proven Clinically Effective has been demonstrated to be clinically effective in improving markers of quality of life and heavy metal metabolism. Reduced Symptoms & Increased Functioning Improved Heavy Metal Metabolism A small, preliminary clinical study at FMRC measured effects on pain, stiffness, quality of life, and heavy metal metabolism with a clinically significant response. FIQ Score MSQ Score FibroQuest Total Score FibroQuest Pain Subscale Metallothionein mrna Expression Urinary Mercury Excretion x x x x x x -51% -40% -55% x x x x x -42% x x x x x x x x x x x x x +19% x x x x +87% x x x x x Study protocol consisted of a modified elimination diet plus 2 servings of daily for 4 weeks. Baseline Visits 5-7 Clinically significant reduction ( 20) in FIQ* score among half of subjects. Reduction in MSQ* score, a measure of physical and mental well-being, suggesting fewer symptoms and better overall quality of life. Reduction in total FibroQuest symptoms survey score, as well as subscales for pain and stiffness. Lower scores generally mean greater functional ability. Elevation of mrna expression of metallothionein, a cellular protein that plays a crucial role in the metabolism of heavy metals. Significant elevation in creatinineadjusted excretion of mercury. See the complete Metagenics product line at Metagenics.com/products *FIQ: Fibromyalgia Impact Questionnaire; MSQ: Medical Symptom Questionnaire Represents subjects (n=4) reporting changes in total FIQ score 20, suggested to be clinically significant. Results presented as a mean of scores (visits 5-7) for all subjects versus baseline (visit 1) unless otherwise noted. After a 4-week control phase with UltraClear MACRO (macronutrient base) and the Standard American Diet. Seafood excluded from both diets. This preliminary subgroup analysis conducted at the Functional Medicine Research Center (FMRC) the clinical research arm of Metagenics, Inc. does not demonstrate statistically significant results. Reference 1. Konda VR. Proprietary Laboratory Report. Gig Harbor, WA: MetaProteomics; 2009.

4 Nutraceuticals for Metabolic Detoxification Nutraceuticals for Metabolic Detoxification liver Support* Improved formula AdvaClear AdvaClear provides daily support for balanced activity of the Phase I and Phase II detoxification pathways.* Promotes overall well-being by supporting balanced detoxification.* Directions: Take two capsules one to three times daily or as directed by your healthcare practitioner. Form: 42 Capsules, 126 Capsules Warning: Excess vitamin A intake may be toxic and may increase the risk of birth defects. Pregnant women and women who may become pregnant should not exceed 5000 IU of preformed vitamin A (retinyl palmitate) per day. Caution: If pregnant or nursing, or taking medication, consult your healthcare practitioner before use. Formulated to Exclude: Wheat, gluten, soy, dairy products, egg, nuts, tree nuts, fish, crustacean shellfish, colors, artificial sweeteners, and preservatives. Capsules are composed of plant-derived ingredients. Betatene mixed carotenoids. As Metafolin US Patents 5,997,915; 6,254,904. Glutathione Support* NEW FORMULA GlutaClear GlutaClear provides a blend of key ingredients designed to support healthy glutathione levels and antioxidant systems in the body. Glutathione plays an important role in protecting the body against oxidative stress and detoxifying harmful compounds. Preliminary research suggests glutathione may also help Metagenics offers a full line of science-based formulas to help reduce your patients chemical burden to help them stay healthy and vibrant. * Features enhanced bifunctional detoxification support with methylated vitamin B 12 and folate.* Provides antioxidant protection against Heavy Metal Metabolism support* MetalloClear MetalloClear is designed to help patients stay healthy by protect mitochondria the principle source of cellular energy from damaging pro-oxidant influences.* reactive oxygen intermediates produced providing specialized support Helps protect cells throughout the body during the detoxification process.* for heavy metal metabolism.* from oxidative damage that may influence cellular aging.* Serving size: 2 Capsules May help improve overall redox status Vitamin A [33% (834 IU) as retinyl palmitate, 67% (1666 IU) as beta-carotene ] Vitamin C (as ascorbic acid) Vitamin D (cholecalciferol) Vitamin E (as d-alpha tocopheryl succinate and mixed tocopherols) Thiamin (as thiamin mononitrate) Riboflavin Niacin (as niacinamide and niacin) Vitamin B 6 (as pyridoxine HCl) Folate (as calcium L-5- methyltetrahydrofolate ) Vitamin B 12 (as methylcobalamin) Biotin Pantothenic Acid (as D-calcium pantothenate) Zinc (as zinc citrate) Selenium (as selenomethionine) Copper (as copper citrate) Manganese (as manganese citrate) Molybdenum (as molybdenum aspartate) Silymarin (from milk thistle seed extract, Silybum marianum) Catechins Epigallocatechin Gallate (EGCG) (from decaffeinated green tea leaf, Camellia sinensis) Artichoke Leaf Extract (Cynara scolymus) (containing cynarin and chlorogenic acid) Watercress Whole Plant 4:1 Extract (Nasturtium officinale) Ellagic Acid (from pomegranate whole fruit extract, Punica granatum) N-Acetylcysteine Sodium Sulfate Taurine Choline (as choline bitartrate) Other Ingredients: Hydroxypropylmethylcellulose, magnesium stearate (vegetable), and silica IU 133 mg 33 IU 67 IU 10 mg 5 mg 23 mg 17 mg 268 mcg 33 mcg 66 mcg 33 mg 6.5 mg 50 mcg 0.65 mg 1.65 mg 66 mcg 34 mg 22 mg 166 mg 134 mg 33 mg 66 mg 100 mg 117 mg 66 mg Preliminary research conducted at the FMRC suggests MetalloClear may upregulate the genetic expression of an enzyme involved in the metabolism of some heavy metals.* Helps to modulate oxidative stress associated with heavy metal metabolism.* Serving size: 3 Tablets Zinc (as zinc citrate) Andrographis (Andrographis paniculata) Aerial Part Extract Turmeric (Curcuma longa) Rhizome Extract [standardized to 95% (1) curcuminoids] Proprietary Blend of Hops (Humulus lupulus) and Luduxin 5 mg mg 2645 mg Other Ingredients: Microcrystalline cellulose, cellulose, stearic acid (vegetable), croscarmellose sodium, silica, and coating (water, hypromellose, medium chain triglycerides, and hydroxypropylcellulose). Directions: Take three tablets twice daily with food, or as directed by your healthcare practitioner. Form: 180 Tablets Warning: Do not use if pregnant, nursing, or if taking anticoagulants. Caution: If taking medication, please consult your healthcare practitioner before use. Keep out of the reach of children. This product is Gluten Free and Vegetarian. Luduxin consists of reduced iso-alpha acids (from hops extract, Humulus lupulus) and magnesium salt produced via a proprietary process. through influencing signaling molecules, such as tumor necrosis factor-alpha (TNF-a) and nuclear factor-kappa B (NF-kB).* Supports hepatic detoxification function.* Serving size: 2 Tablets Vitamin C (as ascorbic acid) Niacin (as niacinamide) Selenium (as selenomethionine) N-Acetylcysteine Broccoli (Brassica oleracea L. var. italica) Seed Extract (providing 5 mg sulforaphane glucosinolate) 500 mg 7 75 mcg mg Other Ingredients: Microcrystalline cellulose, cellulose, stearic acid (vegetable), silica, and coating (water, hypromellose, medium chain triglycerides, and hydroxypropylcellulose). Directions: Take two tablets twice daily with food or as directed by your healthcare practitioner. Form: 120 Tablets CAUTION: If you are pregnant or nursing, consult your healthcare practitioner before use. Formulated to Exclude: Wheat, soy, dairy products, egg, milk, nuts, tree nuts, fish, crustacean shellfish, colors, artificial sweeteners, and preservatives. * These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure, or prevent any disease. To order, contact your Metagenics Representative or call: US or Canada See the complete Metagenics product line at Metagenics.com/products

5 Metagenics 100 Avenida La Pata San Clemente, CA These certifications for Good Manufacturing Practices demonstrate the Metagenics commitment to purity and quality. MET Metagenics, Inc. All Rights Reserved. Metagenics is committed to using only environmentally-friendly papers and inks.