Pfizer Pipeline. May 9, 2013
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1 Pfizer Pipeline May 9, 2013
2 Disclaimer As some programs are still confidential, some candidates may not be identified in this list. In these materials, Pfizer discloses Mechanism of Action (MOA) information for candidates from 3 through regulatory approval. With a view to expanding the transparency of our pipeline, Pfizer is including new indications or enhancements, which target unmet medical need or represent significant commercial opportunities. The information contained on these pages is correct as of May 9, Visit Pfizer.com/pipeline, Pfizer s online database where you can learn more about our portfolio of new medicines and find out more about our Research and Development efforts around the world. 2
3 Table of Contents Pfizer Pipeline Snapshot 4 Cardiovascular & Metabolic Diseases 5 Inflammation & Immunology 6 Neuroscience & Pain 7 Oncology 8 Vaccines 9 Other Areas of Focus (including Biosimilars and Rare Diseases) 10 Projects Discontinued Since Last Update 11 3
4 Pfizer Pipeline Snapshot Discovery Projects 2 programs advanced or are new Pfizer Pipeline Snapshot as of May 9, In Reg Total 74 Pipeline represents progress of R&D programs as of May 9, 2013 Included are 56 NMEs, 16 additional indications, plus 2 biosimilars 4 projects discontinued since last update Recent Approval - Bosulif for Treatment of Previously Treated Chronic Myelogenous Leukemia (EU) Discovery Projects 9 programs advanced or are new Pfizer Pipeline Snapshot as of February 28, In Reg Total 78 Pipeline represents progress of R&D programs as of February 28, 2013 Included are 61 NMEs, 15 additional indications, plus 2 biosimilars 4 projects discontinued since last update Recent Approval - Eliquis for Prevention of Stroke and Systemic Embolism in patients with Nonvalvular Atrial Fibrillation (U.S./EU) 4
5 Pfizer Pipeline May 9, 2013 Therapeutic Area Cardiovascular and Metabolic Diseases Compound Name Mechanism of Action ( 3 through regulatory approval) Eliquis (apixaban) Factor Xa Inhibitor Venous Thromboembolism Prevention (U.S.) 3 Eliquis (apixaban) Factor Xa Inhibitor Venous Thromboembolism Treatment 3 ertugliflozin (PF ) Diabetes Mellitus-Type 2 2 RN316 (PF ) Hypercholesterolemia (Biologic) 2 PF Diabetes Mellitus-Type 2 2 PF Diabetic Nephropathy 2 PF Diabetic Nephropathy 2 PF Diabetes Mellitus-Type 2 (Biologic) 1 PF Diabetes Mellitus-Type 2 1 RN317 (PF ) Hypercholesterolemia (Biologic) 1 PF Acute Coronary Syndrome 1 5
6 Pfizer Pipeline May 9, 2013 (cont d) Therapeutic Area Compound Name Mechanism of Action ( 3 through regulatory approval) tofacitinib JAK Inhibitor Rheumatoid Arthritis (EU) Registration Xeljanz (tofacitinib) JAK Inhibitor Psoriasis (Oral) 3 Xeljanz (tofacitinib) JAK Inhibitor Ulcerative Colitis 3 PF Rheumatoid Arthritis 2 PF Ulcerative Colitis (Biologic) 2 anrukinzumab (IMA-638) Ulcerative Colitis (Biologic) 2 Inflammation and Immunology PF Crohn s Disease, Ulcerative Colitis (Biologic) 2 PF Crohn s Disease, Lupus (Biologic) 2 PH Chronic Obstructive Pulmonary Disease 2 PD Sarcoidosis, *Lupus (Biologic) 2 PF (EXC 001) Dermal Scarring 2 Xeljanz (tofacitinib) Psoriatic Arthritis, Ankylosing Spondylitis, Psoriasis (Topical), Crohn s Disease 2 Dekavil Rheumatoid Arthritis (Biologic) 1 PF Chronic Obstructive Pulmonary Disease 1 PF Diabetes Mellitus-Type 1 (Biologic) 1 Indicates that the project is either new or has progressed in phase since the previous portfolio update of Pfizer.com * Note: Additional indications in 1 6
7 Pfizer Pipeline May 9, 2013 (cont d) Therapeutic Area Compound Name Mechanism of Action ( 3 through regulatory approval) Celebrex COX-2 Chronic Pain (U.S.) Registration Neuroscience & Pain Remoxy ALO-02 Oxycodonenaltrexone core Mu-type opioid receptor (MOR-1) Agonist Mu-type opioid receptor (MOR-1) Agonist Moderate to Severe Pain (U.S.) Registration Moderate to Severe Pain 3 Lyrica Alpha-2 Delta Ligand Peripheral Neuropathic Pain 3 Lyrica Alpha-2 Delta Ligand CR (once a day dosing) 3 tanezumab Nerve Growth Factor Inhibitor OA Signs and Symptoms (Biologic) (on clinical hold) 3 PF (SAM-760) Alzheimer s Disease 2 PF Stroke Recovery 2 tanezumab Cancer Pain (Biologic) 2 PF Chronic Pain 1 PF (AAB-003) Alzheimer s Disease (Biologic) 1 PF Schizophrenia 1 PF Chronic Pain 1 PF Acute and Chronic Pain 1 7
8 Pfizer Pipeline May 9, 2013 (cont d) Therapeutic Area Oncology Compound Name dacomitinib (PF ) dacomitinib (PF ) Mechanism of Action ( 3 through regulatory approval) pan-her Inhibitor Previously Treated Advanced Non-Small Cell Lung Cancer 3 pan-her Inhibitor 1 st Line Non-Small Cell Lung Cancer 3 Xalkori (crizotinib) c-met-alk Inhibitor ALK-Positive 1st and 2nd Line (supports potential full approval in the U.S.) Non- Small Cell Lung Cancer, *Cancer 3 Inlyta (axitinib) VEGF Tyrosine Kinase Inhibitor Renal Cell Carcinoma Adjuvant (Asia only) 3 Sutent Multiple Tyrosine Kinase Inhibitor Renal Cell Carcinoma Adjuvant 3 palbociclib (PD ) CDK 4,6 Kinase Inhibitor 1 st Line Advanced Breast Cancer, *Cancer 3 inotuzumab ozogamicin Aggressive Non-Hodgkin Lymphoma (Biologic) i 3 inotuzumab ozogamicin Acute Lymphoblastic Leukemia (Biologic) 3 Inlyta (axitinib) Liver Cancer 2 dacomitinib (PF ) Cancer 2 PF Endometrial Cancer, *Cancer 2 PF Cancer 1 PF Cancer (Biologic) 1 PD Cancer (in combination with PF ) 1 PF Cancer (Biologic) 1 PF Acute Myelocytic Leukemia 1 * Note: Additional indications in 1 8
9 Pfizer Pipeline May 9, 2013 (cont d) Therapeutic Area Compound Name Mechanism of Action ( 3 through regulatory approval) Vaccines MnB rlp2086 (PF ) Adolescent and Young Adult Meningitis B 3 ACC-001 (PF ) Alzheimer s Disease 2 4-Antigen Staphylococcus Aureus Vaccine (SA4Ag) (PF ) Staph Aureus 2 PF Smoking Cessation 1 PF Clostridium Difficile Colitis 1 PF Asthma 1 9
10 Pfizer Pipeline May 9, 2013 (cont d) Therapeutic Area Compound Name Mechanism of Action ( 3 through regulatory approval) Other Areas of Focus (Rare Diseases) tafamidis meglumine PF (GMI-1070) Transthyretin (TTR) Dissociation Inhibitor Transthyretin familial amyloid polyneuropathy (U.S.) Vaso-occlusive crisis associated with Sickle Cell Disease Registration 2 PF Hemophilia (Biologic) 1 PF Muscular Dystrophies (Biologic) 1 PF Spinal Muscular Atrophy 1 Other Areas of PF Rheumatoid Arthritis (Biosimilar) 1 Focus (Biosimilars) PF Metastatic Breast Cancer (Biosimilar) 1 Other Areas of Focus bazedoxifeneconjugated estrogens Tissue Selective Estrogen Complex Menopausal Vasomotor Symptoms (U.S.) / (EU) Registration Viviant Selective Estrogen Receptor Modulator Osteoporosis Treatment and Prevention (U.S.) Registration Zithromax/chloroquine 5-OS Ribosome Inhibitor Malaria 3 bosutinib Autosomal Dominant Polycystic Kidney Disease 2 PNU Tuberculosis 2 Biosimilar 10
11 Projects Discontinued from Development since February 28, 2013 Compound Name Mechanism of Action ( 3 through regulatory approval) RN6G (PF ) Age-Related Macular Degeneration (Biologic) 2 PF Cancer (Biologic) 1 CVX 096 (PF ) Diabetes Mellitus-Type 2 (Biologic) 1 CVX 060 (PF ) Renal Cell Carcinoma, *Cancer (Biologic) 1 * Note: Additional indications in 1 11
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