Core therapeutic areas

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1 Core therapeutic areas Platforms for growth Luke Miels, Executive Vice President, Global Portfolio & Product Strategy and Corporate Affairs

2 Current business is led by core therapeutic areas Sales 9M % Infection, Neuroscience, Gastrointestinal 12% 19% 38% Oncology RIA CVMD 69% Note: RIA: Respiratory, Inflammation & Autoimmunity CVMD: Cardiovascular & Metabolic Disease 2 Core therapeutic areas

3 Broad geographical presence; Emerging Markets strength US 39% of sales Europe 25% of sales China 9% of sales Japan 9% of sales Emerging Markets (ex-china) 13% of sales ROW Established (ex-japan) 5% of sales Note: Sales 9M Core therapeutic areas

4 Respiratory, Inflammation & Autoimmunity (RIA) Cardiovascular & Metabolic Disease (CVMD) Oncology 4 Core therapeutic areas

5 Respiratory: Unique position in bringing leading medicines to patients Large & small molecules with compelling science Diversity in formulation to enable unique combinations Leading devices & choice for patients 5 Core therapeutic areas

6 Respiratory: Unmet need remains in asthma and COPD Asthma COPD Active patients, millions, 2014 GOLD-defined patients, millions, 2014 GINA step GOLD stage 1.8m severe, m severe, 60 inadequately inadequately 1-3 controlled despite 1-2 controlled despite compliance compliance Asthma prevalence Diagnosed Treated Poor control COPD prevalence Diagnosed Treated Poor control Note: G7 markets = US, France, Germany, Italy, Spain, UK, Japan Source: Decision Resources; Adelphi DSP 2012; other 6 Core therapeutic areas

7 COPD: Affects ~300 million* people; highest prevalence in developing countries Male smoking prevalence trends by region (2011) Lifetime male smoking prevalence: 60% and above % % % % Below 20% No Data * Global estimate of diagnosed and undiagnosed patients Source: Decision Resources; Adelphi DSP 2012; AZ internal analysis of G8 and ROW uplift 7 Core therapeutic areas

8 Symbicort & Pulmicort: Growth by EM / Japan, new indications & new devices Emerging Markets / Japan Market growth driven by: Improving diagnosis Improving access to drug treatment Environmental factors and smoking New indications COPD label updates COPD exacerbations US Asthma SMART labelling Mild asthma: Ex-US as needed Symbicort / PT001 open triple New devices Intelligent device EU Symbicort pmdi EU Symbicort BAI Symbicort Pearl co-suspension Pulmicort nebuliser expansion and Pearl co-formulation Source: UN Population Database, IMS Midas, other forecasts 8 Core therapeutic areas

9 Symbicort: Resilience driven by devices Negative impact of switch is well documented * Successful treatment Partially successful treatment Unsuccessful treatment Change in SABA dose Device has a very strong impact on prescription decision **,*** 57-69% of healthcare providers rate device as having very significant impact Proportion of patients (%) Switch (n=824) Non-switch (n=824) Mean 95% CI change in SABA daily dose 0% 0% 2% 4% 6% 9% 23% 32% 13% 11% Healthcare providers switch device typically in <10% of consultations Thomas M, Price D, Chrystyn H, et al. Inhaled corticosteroids for asthma: Impact of practice level device switching on asthma control. BMC Pulm Med 2009; 9: 1. ** Qual MR ; 70 HCP and 149 Patient Depth Interviews; Chn, Jpn, Ge, Sp & USA; Q Fast Forward Research *** Quant MR; 882 Physician On-line survey; Chn Jpn, Ge, Sp & USA; Q IPSOS 9 Core therapeutic areas

10 Inflammation & Autoimmunity: Strategy Progressing pipeline of first-in-class, best-in-class medicines Rheumatology Dermatology Gastrointestinal Gout Lupus Rheumatoid arthritis Co-development with Amgen Psoriasis and psoriatic arthritis Co-development with Amgen Crohn s disease Ulcerative colitis 10 Core therapeutic areas

11 Inflammation & Autoimmunity: Significant growth potential Global markets for rheumatoid arthritis, psoriasis, psoriatic arthritis, lupus, ulcerative colitis, Crohn s disease and gout $bn $50bn $30bn Now RA PsO&PsA Lupus UC&CD Gout Future Source: IMS, biologic and novel oral brand sales by indication; Decision Resources 11 Core therapeutic areas

12 Respiratory, Inflammation & Autoimmunity (RIA) Cardiovascular & Metabolic Disease (CVMD) Oncology 12 Core therapeutic areas

13 Diabetes: Significant T2D disease burden exists globally 380 million people with diabetes worldwide Anticipated to grow to 590 million by % increase in prevalence Lower T2D mortality Significant increase in Emerging Markets Source: International Diabetes Foundation Atlas 6 edition, International Diabetes federation Core therapeutic areas

14 Diabetes: Non-insulin diabetes market to continue endemic growth Expected revenues for insulin and other diabetes products $bn Other SGLT-2 GLP-1 DPP-4 Insulin Source: Decision Resources (2014), Type 2 Diabetes Therapy 14 Core therapeutic areas

15 Diabetes: Innovative portfolio spanning all non-insulin classes DPP-4 Orals SGLT-2 FDC SGLT-2 / DPP-4 saxa-dapa Injectables GLP-1 Amylin analogue 15 Core therapeutic areas

16 Brilinta: Strengthening momentum Ticagrelor also increases adenosine, augments vasodilation, coronary flow, inhibition of platelet function, and dyspnoea ATLANTIC Ambulance as effective as Cath-Lab Europe label change ESC, ATLANTIC & APOLLO PEGASUS headline Q Q DOJ closure New AHA guidelines AHA APOLLO: ~1 in 5 patients will suffer an MI, stroke or CV death within the first year after an MI Ticagrelor >clopidogrel for ischaemic guided and early invasive NSTE-ACS patients 16 Core therapeutic areas

17 Respiratory, Inflammation & Autoimmunity (RIA) Cardiovascular & Metabolic Disease (CVMD) Oncology 17 Core therapeutic areas

18 Oncology: Cancer incidence a global healthcare challenge Breast cancer treated patients Over 8.2m adults die each year from cancer Over 13m people are predicted to die from cancer in , , , , US EU5 JP CN 1,200,000 1,000, , , , ,000 0 NSCLC 1L treated patients US EU5 JP CN 100,000 80,000 60,000 40,000 20,000 Ovarian cancer 1L treated patients US EU5 JP CN Source: NSCLC: Kantar Health Patient Metrics (US, UK, Spain, Italy), AZ internal sources (France, Germany, Japan and China) Breast: Kantar Health Patient Metrics (US, EU5, Japan), AZ internal sources (China) Ovarian: Kantar Health Patient Metrics (US, EU5, Japan); Decision Resources (China, Urban) Global Incidence and Mortality Numbers: Globocan 2012 (IARC) Projection. Population forecasts taken from UN, World Populations Prospects (2012 revision) Forecast market size Decision Resources Pharmaview 18 Core therapeutic areas

19 Increasing importance of specialty care Primary care vs specialty care sales over time Future Now Primary Care Specialty Care 19 Core therapeutic areas

20 Confidence in strategy Core therapeutic areas platform for growth Broad geographical presence with strong EMs Aligned with pipeline Pipeline driving a balance of primary and specialty care 20 Core therapeutic areas

21 Core therapeutic areas Platforms for growth Luke Miels, Executive Vice President, Global Portfolio & Product Strategy and Corporate Affairs

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